Patent Applications published on Dec 26, 2013 - page 18

#5101 ✅ Patent 9,120,751 granted on 2015-09-01
US20130345240A1
Chemistry; metallurgy

Compounds that modulate intracellular calcium

#5102
US20130345241A1
Chemistry; metallurgy

DIHYDROOXAZOL-2-AMINE DERIVATIVES

#5103
US20130345242A1
Chemistry; metallurgy

HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF E1 ACTIVATING ENZYMES

#5104
US20130345243A1
Chemistry; metallurgy

1H-PYROLLO[3,2-D]PYRIMIDINEDIONE DERIVATIVES

#5105
US20130345244A1
Human necessities

LOCAL TREATMENT OF NEUROFIBROMAS

#5106 ✅ Patent 8,969,366 granted on 2015-03-03
US20130345245A1
Chemistry; metallurgy

Substituted pyrimidinylpyrrolopyridinone derivatives, process for their preparation and their use as kinase inhibitors

#5107 ✅ Patent 9,000,182 granted on 2015-04-07
US20130345246A1
Chemistry; metallurgy

2H-imidazol-4-amine compounds and their use as BACE inhibitors

#5108 ✅ Patent 9,000,183 granted on 2015-04-07
US20130345247A1
Chemistry; metallurgy

Cyclohexane-1,2′-indene-1′,2″-imidazol compounds and their use as BACE inhibitors

#5109 ✅ Patent 9,000,184 granted on 2015-04-07
US20130345248A1
Chemistry; metallurgy

Cyclohexane-1,2′-naphthalene-1′,2″-imidazol compounds and their use as BACE inhibitors

#5110
US20130345249A1
Human necessities

Formulations for the prevention and treatment of Wolbachia-related disease

#5111 ✅ Patent 10,071,088 granted on 2018-09-11
US20130345250A1
Human necessities

Anti-nausea drug combinations

#5112 ✅ Patent 8,901,148 granted on 2014-12-02
US20130345251A1
Chemistry; metallurgy

Large substituent, non-phenolic opioids and methods of use thereof

#5113 ✅ Patent 8,912,213 granted on 2014-12-16
US20130345252A1
Chemistry; metallurgy

Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors

#5114 ✅ Patent 9,012,640 granted on 2015-04-21
US20130345253A1
Human necessities

Cabergoline derivatives

#5115
US20130345254A1
Chemistry; metallurgy

CYCLOHEXANE SUBSTITUTED AMINO CYCLOPENTANE DERIVATIVES AS USEFUL CCR2 ANTAGONISTS

#5116 ✅ Patent 8,796,328 granted on 2014-08-05
US20130345255A1
Chemistry; metallurgy

TRPV1 antagonists

#5117 ✅ Patent 8,809,537 granted on 2014-08-19
US20130345256A1
Chemistry; metallurgy

N-ethyl-4-hydroxyl-1-methyl-5-(methyl(2,3,4,5,6-pentahydroxyhexyl)amino)-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

#5118
US20130345257A1
Human necessities

COMPOSITION FOR LUPUS NEPHRITIS AND METHODS OF MAKING AND USING THE SAME

#5119 ✅ Patent 9,604,963 granted on 2017-03-28
US20130345258A1
Chemistry; metallurgy

Amino-quinolines as kinase inhibitors

#5120
US20130345259A9
Human necessities

Use of Levocabastine for Modulating Generation of Pro-Inflammatory Cytokines

#5121
US20130345260A1
Human necessities

High Viscosity Liquid Controlled Delivery System and Medical or Surgical Device

#5122 ✅ Patent 8,710,082 granted on 2014-04-29
US20130345261A1
Chemistry; metallurgy

Benzimidazole inhibition of biofilm formation

#5123
US20130345262A1
Human necessities

METHOD FOR PREVENTION OF STROKE

#5124 ✅ Patent 9,366,682 granted on 2016-06-14
US20130345263A1
Physics

Use of stathmin as a biomarker of drug response to furazanobenzimidazoles

#5125 ✅ Patent 9,018,232 granted on 2015-04-28
US20130345264A1
Human necessities

Substituted N-aryl pyridinones

#5126 ✅ Patent 9,468,598 granted on 2016-10-18
US20130345265A1
Human necessities

Oral dosage form containing a PDE 4 inhibitor as an active ingredient and polyvinylpyrrolidon as excipient

#5127
US20130345266A1
Human necessities

PEST CONTROL COMPOSITION AND PEST CONTROL METHOD

#5128 ✅ Patent 9,138,439 granted on 2015-09-22
US20130345267A1
Chemistry; metallurgy

Methods and compositions for modulating P300/CBP activity

#5129
US20130345268A1
Chemistry; metallurgy

Methods and Compositions for the Treatment of RAS Associated Disorders

#5130 ✅ Patent 9,394,228 granted on 2016-07-19
US20130345269A1
Chemistry; metallurgy

Methods of treatment using lipid compounds

#5131
US20130345270A1
Chemistry; metallurgy

METHODS OF TREATING CANCER AND OTHER DISORDERS

#5132
US20130345271A1
Chemistry; metallurgy

POLYMORPHIC, CRYSTALLINE AND MESOPHASE FORMS OF SODIUM 2-(5-BROMO-4-(4-CYCLOPROPYLNAPHTHALEN-1-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO) ACETATE, AND USES THEREOF

#5133 ✅ Patent 9,000,185 granted on 2015-04-07
US20130345272A1
Chemistry; metallurgy

Cycloalkyl ether compounds and their use as BACE inhibitors

#5134 ✅ Patent 9,469,648 granted on 2016-10-18
US20130345273A1
Chemistry; metallurgy

Reversal of drug-induced neuromuscular block using novel molecular containers

#5135 ✅ Patent 8,877,788 granted on 2014-11-04
US20130345274A1
Human necessities

Allantoin-containing skin cream

#5136 ✅ Patent 9,630,951 granted on 2017-04-25
US20130345275A1
Chemistry; metallurgy

1,3-dihydroimidazole-2-thione derivatives as inhibitors of dopamine-beta-hydroxylase

#5137 ✅ Patent 9,757,359 granted on 2017-09-12
US20130345276A1
Human necessities

Synthetic triterpenoids and methods of use in the treatment of disease

#5138 ✅ Patent 9,642,835 granted on 2017-05-09
US20130345277A1
Human necessities

Modulators of GTPase and use in relevant treatment

#5139 ✅ Patent 8,802,714 granted on 2014-08-12
US20130345278A1
Human necessities

Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases

#5140 ✅ Patent 9,139,521 granted on 2015-09-22
US20130345279A1
Chemistry; metallurgy

Polymorphs of azabicyclohexane

#5141 ✅ Patent 9,393,204 granted on 2016-07-19
US20130345280A1
Human necessities

Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders

#5142 ✅ Patent 8,957,103 granted on 2015-02-17
US20130345281A1
Chemistry; metallurgy

Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment

#5143 ✅ Patent 8,883,843 granted on 2014-11-11
US20130345282A1
Chemistry; metallurgy

Substituted isoindoline-1,3-dione derivatives

#5144
US20130345283A1
Chemistry; metallurgy

PROCESS FOR THE PREPARATION OF ROTIGOTINE

#5145 ✅ Patent 9,506,063 granted on 2016-11-29
US20130345284A1
Chemistry; metallurgy

SiRNA compositions and methods for treatment of HPV and other infections

#5146 ✅ Patent 8,802,649 granted on 2014-08-12
US20130345285A1
Chemistry; metallurgy

Methods and compositions for inhibiting the proliferation of cancer cells

#5147 ✅ Patent 9,339,513 granted on 2016-05-17
US20130345286A1
Human necessities

Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes

#5148
US20130345287A1
Chemistry; metallurgy

METHODS OF ANALYSIS OF POLYMORPHISMS AND USES THEREOF

#5149 ✅ Patent 9,163,235 granted on 2015-10-20
US20130345288A1
Chemistry; metallurgy

Inhibitors of the miR-15 family of micro-RNAs

#5150
US20130345289A1
Chemistry; metallurgy

ADULT STEM CELLS, MOLECULAR SIGNATURES, AND APPLICATIONS IN THE EVALUATION, DIAGNOSIS, AND THERAPY OF MAMMALIAN CONDITIONS

#5151
US20130345290A1
Chemistry; metallurgy

PHARMACEUTICAL COMPOSITION CONTAINING L-DNA

#5152 ✅ Patent 9,365,849 granted on 2016-06-14
US20130345291A1
Chemistry; metallurgy

Methods and compositions for the specific inhibition of gene expression by double-stranded RNA

#5153 ✅ Patent 9,273,126 granted on 2016-03-01
US20130345292A1
Chemistry; metallurgy

Humanized antibodies against the beta-amyloid peptide

#5154 ✅ Patent 8,759,314 granted on 2014-06-24
US20130345293A1
Chemistry; metallurgy

Methods for treating multiple sclerosis using antisense oligonucleotides

#5155 ✅ Patent 9,839,698 granted on 2017-12-12
US20130345294A1
Human necessities

Light-switchable gene expression system

#5156
US20130345295A1
Human necessities

TARGETED ONCOLYTIC ADENOVIRUS FOR TREATMENT OF HUMAN TUMORS, CONSTRCUTION METHOD AND APPLICATION THEREOF

#5157
US20130345296A1
Human necessities

Compositions Comprising a Taxane for Coating Medical Devices

#5158 ✅ Patent 9,801,818 granted on 2017-10-31
US20130345297A1
Human necessities

Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug

#5159 ✅ Patent 10,894,087 granted on 2021-01-19
US20130345298A1
Human necessities

Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds

#5160 ✅ Patent 8,906,956 granted on 2014-12-09
US20130345299A1
Human necessities

Composition comprising (−)-Δ-trans-tetrahydrocannabinol

#5161
US20130345300A1
Human necessities

SMALL MOLECULE MODULATORS OF THE COLD AND MENTHOL RECEPTOR TRPM8

#5162 ✅ Patent 8,716,330 granted on 2014-05-06
US20130345301A1
Human necessities

Supplement composition and method of use

#5163 ✅ Patent 8,822,531 granted on 2014-09-02
US20130345302A1
Chemistry; metallurgy

Honokiol analogs and their use in treating cancers

#5164
US20130345303A1
Human necessities

USE OF FERRIC CITRATE IN THE TREATMENT OF CHRONIC KIDNEY DISEASE PATIENTS

#5165 ✅ Patent 8,901,171 granted on 2014-12-02
US20130345304A1
Chemistry; metallurgy

Compounds for suppressing a peripheral nerve disorder induced by an anti-cancer agent

#5166
US20130345305A1
Human necessities

POWDER EMULSIFIER

#5167
US20130345306A1
Human necessities

IDENTIFICATION OF C3 COMPLEMENT MOLECULE AT THE SITE OF INJURY TO BLOOD VESSELS IN THE RETINA OF OXYGEN EXPOSED ANIMALS

#5168 ✅ Patent 9,241,887 granted on 2016-01-26
US20130345307A1
Human necessities

Systems and methods for skin rejuvenation

#5169 ✅ Patent 8,729,122 granted on 2014-05-20
US20130345308A1
Human necessities

Pharmaceutical and nutraceutical compositions of abscisic acid

#5170
US20130345309A1
Human necessities

MALIC ACID-ENRICHED PLANT EXTRACT

#5171
US20130345310A1
Human necessities

SOLID COMPOSITION CONTAINING THE INGREDIENT RASAGILINE

#5172 ✅ Patent 8,912,362 granted on 2014-12-16
US20130345311A1
Chemistry; metallurgy

Synthesis of triethylenetetramines

#5173
US20130345312A1
Chemistry; metallurgy

TREATMENT OF MITOCHONDRIAL DISEASES WITH NAPHTHOQUINONES

#5174 ✅ Patent 8,962,693 granted on 2015-02-24
US20130345313A1
Human necessities

Method for the treatment or prevention of lower urinary tract symptoms

#5175 ✅ Patent 9,034,349 granted on 2015-05-19
US20130345314A1
Human necessities

Compositions and methods for treating a damaged cardiovascular element

#5176
US20130345315A1
Human necessities

WATER-RELEASING COSMETIC COMPOSITION

#5177
US20130345316A1
Human necessities

WATER-RELEASING COSMETIC COMPOSITION

#5178
US20130345317A1
Human necessities

WATER-RELEASING COSMETIC COMPOSITION INCLUDING A HYDROPHOBIC SILICA AND A CO-EMULSIFIER

#5179
US20130345318A1
Chemistry; metallurgy

SILICONE POLYETHERS AND PREPARATION THEREOF FROM POLYETHERS BEARING METHYLIDENE GROUPS

#5180 ✅ Patent 9,259,473 granted on 2016-02-16
US20130345319A1
Human necessities

Polymer hydrogel adhesives formed with multiple crosslinking mechanisms at physiologic pH

#5181 ✅ Patent 10,668,156 granted on 2020-06-02
US20130345320A1
Human necessities

Active-ingredient-containing solid dispersions based on diethylaminoethyl methacrylate copolymers

#5182
US20130345321A1
Human necessities

GENIPIN CROSS-LINKED FIBRIN GELS

#5183
US20130345322A1
Physics

DIAGNOSTIC FOR COLORECTAL CANCER

#5184 ✅ Patent 10,087,078 granted on 2018-10-02
US20130345323A1
Chemistry; metallurgy

Dispersing method of carbon nanotube, dispersing apparatus of carbon nanotube, and carbon nanotube dispersion obtained thereby

#5185 ✅ Patent 9,156,689 granted on 2015-10-13
US20130345324A1
Performing operations; transporting

Process for reforming hydrocarbons

#5186
US20130345325A1
Chemistry; metallurgy

METHOD FOR PRODUCING METHANOL OR HYDROCARBONS FROM A CARBON MATERIAL, INCLUDING A REFORMING STEP, THE OPERATING CONDITIONS OF WHICH ARE SELECTIVELY ADJUSTED

#5187 ✅ Patent 9,067,847 granted on 2015-06-30
US20130345326A1
Chemistry; metallurgy

Process for producing a synthesis gas mixture

#5188
US20130345327A1
Chemistry; metallurgy

PROCESS FOR PRODUCING EXPANDABLE PELLETIZED MATERIAL WHICH COMPRISES POLYLACTIC ACID

#5189 ✅ Patent 9,447,273 granted on 2016-09-20
US20130345328A1
Chemistry; metallurgy

Process for the preparation of granules based on expandable thermoplastic polymers and relative product

#5190 ✅ Patent 8,937,107 granted on 2015-01-20
US20130345329A1
Chemistry; metallurgy

Rigid polyurethane foam and system and method for making the same

#5191
US20130345330A1
Chemistry; metallurgy

METHOD FOR PRODUCING FLEXIBLE POLYURETHANE FOAMS

#5192
US20130345331A1
Chemistry; metallurgy

HIGH-CONCENTRATION POLYMER POLYOL AND METHOD FOR ITS PRODUCTION

#5193 ✅ Patent 8,915,996 granted on 2014-12-23
US20130345332A1
Chemistry; metallurgy

Low dust, light weight filler composition

#5194 ✅ Patent 9,382,457 granted on 2016-07-05
US20130345333A1
Chemistry; metallurgy

Adhesive film, adhesive composition for the same, and optical member including the same

#5195 ✅ Patent 9,770,527 granted on 2017-09-26
US20130345334A1
Human necessities

Cross-linked polymers and implants derived from electrophilically activated polyoxazoline

#5196
US20130345335A1
Chemistry; metallurgy

RUBBER COMPOSITION, METHOD FOR PRODUCING SAME, AND TIRE

#5197
US20130345336A1
Chemistry; metallurgy

TIRE, THE TREAD OF WHICH COMPRISES A THERMOPLASTIC POLYURETHANE BLOCK COPOLYMER

#5198 ✅ Patent 9,932,460 granted on 2018-04-03
US20130345337A1
Chemistry; metallurgy

Rubber composition and pneumatic tire

#5199
US20130345338A1
Chemistry; metallurgy

SYSTEM AND METHOD FOR TREATING AGRICULTURAL SETTINGS

#5200 ✅ Patent 8,853,303 granted on 2014-10-07
US20130345339A1
Chemistry; metallurgy

Recycled crumb rubber coating

#5201
US20130345340A1
Chemistry; metallurgy

Composition for the Optimization of Mineral Building Material Compositions

#5202 ✅ Patent 9,074,077 granted on 2015-07-07
US20130345341A1
Chemistry; metallurgy

Modified cellulose nanofibers, production method thereof, and resin composition using same

#5203 ✅ Patent 8,980,959 granted on 2015-03-17
US20130345342A1
Chemistry; metallurgy

Bi-modal emulsions

#5204 ✅ Patent 9,309,380 granted on 2016-04-12
US20130345343A1
Chemistry; metallurgy

Glass fiber sizing agent and glass fiber-reinforced crystalline resin composition

#5205
US20130345344A1
Chemistry; metallurgy

ADHESION PROMOTING CURATIVE AND STABILIZER SYSTEM FOR ELASTOMER COMPOSITION

#5206 ✅ Patent 8,912,261 granted on 2014-12-16
US20130345345A1
Chemistry; metallurgy

Process for making particulate-free poly(phenylene ether) compositions and photovoltaic backsheet materials derived therefrom

#5207 ✅ Patent 8,981,042 granted on 2015-03-17
US20130345346A1
Chemistry; metallurgy

Cycloaliphatic polyphosphite polymer stabilizers

#5208 ✅ Patent 9,193,864 granted on 2015-11-24
US20130345347A1
Chemistry; metallurgy

Polycarbonate compositions with improved impact resistance

#5209 ✅ Patent 9,512,281 granted on 2016-12-06
US20130345348A1
Chemistry; metallurgy

Process for preparing a masterbatch in the liquid phase

#5210 ✅ Patent 9,029,447 granted on 2015-05-12
US20130345349A1
Chemistry; metallurgy

Thermoplastic resin composition comprising a mixture of slip agents and a mono-or co-extruded, laminated or non-laminated film

#5211 ✅ Patent 9,080,052 granted on 2015-07-14
US20130345350A1
Chemistry; metallurgy

Precursor polymer compositions comprising polybenzimidazole

#5212 ✅ Patent 9,487,636 granted on 2016-11-08
US20130345351A1
Chemistry; metallurgy

Flameproofing

#5213 ✅ Patent 9,255,075 granted on 2016-02-09
US20130345352A1
Chemistry; metallurgy

Benzoxazine resins

#5214
US20130345353A1
Chemistry; metallurgy

THERMOPLASTIC MOLDING COMPOUNDS ON THE BASIS OF STYRENE COPOLYMERS AND POLYAMIDES HAVING IMPROVED LOW-TEMPERATURE TOUGHNESS

#5215
US20130345354A1
Chemistry; metallurgy

MOISTURE-CURABLE HOT MELT ADHESIVE

#5216
US20130345355A1
Chemistry; metallurgy

HOT MELT ADHESIVE

#5217 ✅ Patent 8,809,445 granted on 2014-08-19
US20130345356A1
Chemistry; metallurgy

Room temperature cured vinyl silazane compositions

#5218
US20130345357A1
Chemistry; metallurgy

Composition for Use as an Assay

#5219
US20130345358A1
Chemistry; metallurgy

USE OF BRANCHED ADDITION COPOLYMERS IN CURING SYSTEMS

#5220 ✅ Patent 8,822,593 granted on 2014-09-02
US20130345359A1
Electricity

Curable resin composition, hardened material thereof, and optical semiconductor apparatus

#5221 ✅ Patent 9,376,557 granted on 2016-06-28
US20130345360A1
Chemistry; metallurgy

Process for preparing polyethylene blend comprising metallocene produced resins and chromium produced resins

#5222 ✅ Patent 9,334,396 granted on 2016-05-10
US20130345361A1
Chemistry; metallurgy

Process for preparing polyolefin blends in a device for continuously physically melting and blending the blends

#5223 ✅ Patent 9,505,866 granted on 2016-11-29
US20130345362A1
Chemistry; metallurgy

Acrylic rubber graft copolymer and thermoplastic resin composition

#5224
US20130345363A1
Chemistry; metallurgy

BIODEGRADABLE IMPACT-MODIFIED POLYMER COMPOSITIONS

#5225 ✅ Patent 9,423,528 granted on 2016-08-23
US20130345364A1
Physics

Method of making silicone containing contact lens with reduced amount of diluents

#5226
US20130345365A1
Chemistry; metallurgy

CURABLE FLUOROELASTOMER COMPOSITION

#5227 ✅ Patent 9,428,592 granted on 2016-08-30
US20130345366A1
Chemistry; metallurgy

Partially hydrogenated nitrile rubbers

#5228 ✅ Patent 9,487,613 granted on 2016-11-08
US20130345367A1
Chemistry; metallurgy

Methods for preparation of novel graft copolymers

#5229 ✅ Patent 9,175,110 granted on 2015-11-03
US20130345368A1
Chemistry; metallurgy

Fluoropolymer resin treatment employing melt extrusion and exposure to oxygen source to reduce discoloration

#5230 ✅ Patent 9,145,467 granted on 2015-09-29
US20130345369A1
Chemistry; metallurgy

Biodegradable photoluminescent polymers

#5231
US20130345370A1
Chemistry; metallurgy

SILICONE RESIN COMPOSITION

#5232 ✅ Patent 8,871,896 granted on 2014-10-28
US20130345371A1
Chemistry; metallurgy

Michael addition curing chemistries for sulfur-containing polymer compositions

#5233 ✅ Patent 8,710,159 granted on 2014-04-29
US20130345372A1
Chemistry; metallurgy

Polyfunctional sulfur-containing epoxies and compositions thereof

#5234 ✅ Patent 10,273,315 granted on 2019-04-30
US20130345373A1
Chemistry; metallurgy

Methods for terminating olefin polymerizations

#5235 ✅ Patent 8,796,400 granted on 2014-08-05
US20130345374A1
Chemistry; metallurgy

Double loop technology

#5236
US20130345375A1
Chemistry; metallurgy

OLEFIN POLYMERIZATION CATALYST COMPOSITION AND OLEFIN POLYMERIZATION PROCESS USING THE SAME

#5237 ✅ Patent 9,090,720 granted on 2015-07-28
US20130345376A1
Chemistry; metallurgy

Aluminoxane catalyst activators containing carbocation agents, and use thereof in polyolefin catalysts

#5238 ✅ Patent 9,079,991 granted on 2015-07-14
US20130345377A1
Chemistry; metallurgy

Ethylene copolymers, film and polymerization process

#5239
US20130345378A1
Chemistry; metallurgy

METALLOCENE COMPOUND, CATALYST COMPOSITION INCLUDING THE SAME, AND OLEFIN POLYMERIZATION PROCESS USING THE SAME

#5240 ✅ Patent 9,000,109 granted on 2015-04-07
US20130345379A1
Chemistry; metallurgy

High styrene high vinyl styrene-butadiene rubber and methods for preparation thereof

#5241
US20130345380A1
Chemistry; metallurgy

NOVEL INITIATION PROCESS FOR POLYMERIZATION WITH ACTIVATION USING IONIC LIQUIDS

#5242 ✅ Patent 8,809,471 granted on 2014-08-19
US20130345381A1
Chemistry; metallurgy

Synthesis of making 2,3,3,3-tetrafluoropropene containing fluoropolymers

#5243 ✅ Patent 8,716,421 granted on 2014-05-06
US20130345382A1
Physics

Norbornene-type formate monomers and polymers and optical waveguides formed therefrom

#5244 ✅ Patent 9,187,603 granted on 2015-11-17
US20130345383A1
Chemistry; metallurgy

Bio-based branched and hyperbranched polymers and oligomers

#5245 ✅ Patent 9,289,931 granted on 2016-03-22
US20130345384A1
Performing operations; transporting

Ultrasonic-assisted molding of precisely-shaped articles and methods

#5246 ✅ Patent 8,865,858 granted on 2014-10-21
US20130345385A1
Chemistry; metallurgy

Process for producing a composite material

#5247 ✅ Patent 8,889,814 granted on 2014-11-18
US20130345386A1
Chemistry; metallurgy

Polyetheramine macromonomers comprising two neighboring hydroxyl groups and their use for producing polyurethanes

#5248 ✅ Patent 8,703,899 granted on 2014-04-22
US20130345387A1
Chemistry; metallurgy

Method for producing polyester, and fluorine-containing dicarboxylic acid ester compound

#5249
US20130345388A1
Chemistry; metallurgy

Process for Producing Nitrile-Fatty Acid Compounds

#5250 ✅ Patent 9,018,322 granted on 2015-04-28
US20130345389A1
Chemistry; metallurgy

Controlled release amine-catalyzed, Michael addition-curable sulfur-containing polymer compositions

#5251 ✅ Patent 9,012,601 granted on 2015-04-21
US20130345390A1
Chemistry; metallurgy

Waterbased dimerized rosins and the process to make them

#5252 ✅ Patent 9,273,089 granted on 2016-03-01
US20130345391A1
Chemistry; metallurgy

Composite probes and use thereof in super resolution methods

#5253
US20130345392A1
Chemistry; metallurgy

EDN3-LIKE PEPTIDES AND USES THEREOF

#5254 ✅ Patent 9,376,467 granted on 2016-06-28
US20130345393A1
Chemistry; metallurgy

Cross-linked peptides containing non-peptide cross-linked structure, method for synthesizing cross-linked peptides, and novel organic compound used in method

#5255 ✅ Patent 9,169,293 granted on 2015-10-27
US20130345394A1
Chemistry; metallurgy

NPR-B agonists

#5256 ✅ Patent 9,115,179 granted on 2015-08-25
US20130345395A1
Chemistry; metallurgy

Synthesis of beta-turn peptidomimetic cyclic compounds

#5257
US20130345396A1
Chemistry; metallurgy

ANGIOTENSIN CONVERTING ENZYME INHIBITORY PEPTIDE

#5258
US20130345397A1
Chemistry; metallurgy

METHODS FOR THE SYNTHESIS OF DICARBA BRIDGES IN PEPTIDES

#5259
US20130345398A1
Chemistry; metallurgy

Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy

#5260 ✅ Patent 8,685,668 granted on 2014-04-01
US20130345399A1
Chemistry; metallurgy

Method of expressing proteins with disulfide bridges

#5261 ✅ Patent 9,403,880 granted on 2016-08-02
US20130345400A1
Chemistry; metallurgy

Identification of a human gyrovirus and applications

#5262 ✅ Patent 9,447,167 granted on 2016-09-20
US20130345401A1
Chemistry; metallurgy

Fibrinogen-producing transgenic silkworm

#5263
US20130345402A1
Chemistry; metallurgy

Devices and Methods for Integrated Continuous Manufacturing of Biological Molecules

#5264
US20130345403A1
Chemistry; metallurgy

AQUEOUS FACTOR VIII SOLUTION

#5265
US20130345404A1
Chemistry; metallurgy

Dual Variable Region Antibody-Like Binding Proteins Having Cross-Over Binding Region Orientation

#5266 ✅ Patent 9,353,179 granted on 2016-05-31
US20130345405A1
Chemistry; metallurgy

Binding molecules

#5267
US20130345406A1
Chemistry; metallurgy

STABLE IGG4 ANTIBODIES

#5268 ✅ Patent 9,416,159 granted on 2016-08-16
US20130345407A1
Chemistry; metallurgy

Method of producing a positive inotropic effect using an antibody that binds sodium potassium atpase

#5269 ✅ Patent 9,309,307 granted on 2016-04-12
US20130345408A1
Chemistry; metallurgy

Antibody against amyloid precursor protein signal peptide

#5270 ✅ Patent 8,759,286 granted on 2014-06-24
US20130345409A1
Chemistry; metallurgy

Pharmaceutical compositions comprising a VEGF-D polypeptide

#5271 ✅ Patent 9,200,026 granted on 2015-12-01
US20130345410A1
Chemistry; metallurgy

Antibacterial agents

#5272 ✅ Patent 9,260,465 granted on 2016-02-16
US20130345411A1
Chemistry; metallurgy

Aminoglycoside antibiotics

#5273 ✅ Patent 9,175,026 granted on 2015-11-03
US20130345412A1
Chemistry; metallurgy

Synthesis of thioether containing trialkoxysilanes

#5274
US20130345413A1
Chemistry; metallurgy

MODIFIED CLOSTRIDIAL TOXINS WITH ENHANCED TRANSLOCATION CAPABILITIY

#5275
US20130345414A1
Chemistry; metallurgy

TREATING CANCER WITH VIRAL NUCLEIC ACID

#5276 ✅ Patent 9,139,661 granted on 2015-09-22
US20130345415A1
Chemistry; metallurgy

Methods for biocompatible derivitization of cellulosic surfaces

#5277 ✅ Patent 9,469,696 granted on 2016-10-18
US20130345416A1
Chemistry; metallurgy

Method for processing nanofibrillar cellulose and product obtained by the method

#5278
US20130345417A1
Chemistry; metallurgy

WATER SOLUBLE ANIONIC BACTERIOCHLOROPHYLL DERIVATIVES AND THEIR USES

#5279
US20130345418A1
Chemistry; metallurgy

PROCESS FOR PURIFICATION OF APREPITANT

#5280 ✅ Patent 9,181,229 granted on 2015-11-10
US20130345419A1
Chemistry; metallurgy

Azole derivative

#5281
US20130345420A9
Human necessities

SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST)

#5282 ✅ Patent 8,846,911 granted on 2014-09-30
US20130345421A1
Chemistry; metallurgy

Process of isolating enantiomer components from enantiomer mixtures by particle-size-controlled crystallization

#5283 ✅ Patent 8,962,828 granted on 2015-02-24
US20130345422A1
Chemistry; metallurgy

Method for producing triazinyl-substituted oxindoles

#5284 ✅ Patent 9,458,188 granted on 2016-10-04
US20130345423A1
Chemistry; metallurgy

Efficient peptide couplings and their use in the synthesis and isolation of a cyclopenta (G) quinazoline trisodium salt

#5285 ✅ Patent 8,946,220 granted on 2015-02-03
US20130345424A1
Human necessities

Compositions and uses thereof to ameliorate pain

#5286
US20130345425A1
Physics

HETEROCYCLICAL CHROMOPHORE ARCHITECTURES

#5287 ✅ Patent 9,353,113 granted on 2016-05-31
US20130345426A1
Chemistry; metallurgy

Tetrahydrocarboline derivative

#5288
US20130345427A1
Chemistry; metallurgy

COLORANT COMPOUND DERIVED FROM GENIPA AMERICANA GENIPIN AND GLYCINE

#5289
US20130345428A1
Chemistry; metallurgy

METHOD FOR PRODUCTION OF PRASUGREL HYDROCHLORIDE HAVING HIGH PURITY

#5290 ✅ Patent 8,853,429 granted on 2014-10-07
US20130345429A1
Chemistry; metallurgy

Process and intermediate compounds useful in the preparation of statins

#5291
US20130345430A1
Chemistry; metallurgy

METHOD FOR SYNTHESIZING PIRFENIDONE

#5292 ✅ Patent 9,050,589 granted on 2015-06-09
US20130345431A1
Chemistry; metallurgy

Alkene aziridination

#5293
US20130345432A1
Chemistry; metallurgy

ASYMMETRIC PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES

#5294 ✅ Patent 8,802,862 granted on 2014-08-12
US20130345433A1
Chemistry; metallurgy

1,2-benzisothiazol-3-one compound production method

#5295
US20130345434A1
Chemistry; metallurgy

METHOD FOR PRODUCING 1,2-BENZISOTHIAZOL-3-ONE COMPOUND

#5296 ✅ Patent 8,957,220 granted on 2015-02-17
US20130345435A1
Chemistry; metallurgy

Preparation method of carfentrazone-ethyl

#5297 ✅ Patent 9,018,393 granted on 2015-04-28
US20130345436A1
Chemistry; metallurgy

Method for preparing 2-(N-substituted)-amino-benzimidazole derivatives

#5298 ✅ Patent 8,889,882 granted on 2014-11-18
US20130345437A1
Chemistry; metallurgy

Process for preparing biphenyl imidazole compounds

#5299 ✅ Patent 8,933,248 granted on 2015-01-13
US20130345438A1
Chemistry; metallurgy

3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof

#5300 ✅ Patent 8,877,798 granted on 2014-11-04
US20130345439A1
Chemistry; metallurgy

1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders

#5301
US20130345440A1
Chemistry; metallurgy

CARBOXYLATION OF POLY-/OLIGOTHIOPHENES

#5302 ✅ Patent 9,238,638 granted on 2016-01-19
US20130345441A1
Chemistry; metallurgy

Method for preparing alcohol carbonate using rare earth oxides as catalysts

#5303
US20130345442A1
Chemistry; metallurgy

INSECTICIDAL FERMENTATION BROTH FROM ACTINOMYCETES CONTAINING ENHANCED RATIO OF ACTIVE TO INACTIVE DUNAIMYCINS

#5304
US20130345443A1
Chemistry; metallurgy

FLUOROSULFONYL GROUP-CONTAINING MONOMER AND ITS POLYMER, AND SULFONIC ACID GROUP-CONTAINING POLYMER

#5305 ✅ Patent 8,952,185 granted on 2015-02-10
US20130345444A1
Performing operations; transporting

Production method of optically active dihydrobenzofuran derivative

#5306 ✅ Patent 9,382,225 granted on 2016-07-05
US20130345445A1
Chemistry; metallurgy

Reduction of C—O bonds by catalytic transfer hydrogenolysis

#5307 ✅ Patent 8,889,891 granted on 2014-11-18
US20130345446A1
Chemistry; metallurgy

Method for preparing a furfuranol-based compound and 2-furancarboxylic acid-based compound using an ionic liquid as a solvent

#5308 ✅ Patent 8,658,810 granted on 2014-02-25
US20130345447A1
Chemistry; metallurgy

Method for producing purified dialkyl-furan-2,5-dicarboxylate vapor

#5309 ✅ Patent 8,912,349 granted on 2014-12-16
US20130345448A1
Chemistry; metallurgy

Method for producing purified dialkyl-furan-2,5-dicarboxylate separation and solid liquid separation

#5310 ✅ Patent 8,859,788 granted on 2014-10-14
US20130345449A1
Chemistry; metallurgy

Esterification of furan-2,5-dicarboxylic acid to a dialkyl-furan-2,5-dicarboxylate vapor with rectification

#5311 ✅ Patent 9,156,802 granted on 2015-10-13
US20130345450A1
Chemistry; metallurgy

Separating off 5-hydroxymethylfurfural (HMF) from reaction solutions by steam distillation

#5312 ✅ Patent 8,748,479 granted on 2014-06-10
US20130345451A1
Chemistry; metallurgy

Process for purifying crude furan 2,5-dicarboxylic acid using hydrogenation

#5313 ✅ Patent 8,969,404 granted on 2015-03-03
US20130345452A1
Chemistry; metallurgy

Purifying crude furan 2,5-dicarboxylic acid by hydrogenation

#5314 ✅ Patent 9,073,886 granted on 2015-07-07
US20130345453A1
Chemistry; metallurgy

Process for the depolymerization of a furandicarboxylate containing polyester

#5315
US20130345454A2
Chemistry; metallurgy

A PROCESS FOR THE PREPARATION OF PHYTOSTERYL FERULATE

#5316 ✅ Patent 9,314,471 granted on 2016-04-19
US20130345455A1
Chemistry; metallurgy

Methods of preparing pharmaceutical solid state forms

#5317 ✅ Patent 8,987,485 granted on 2015-03-24
US20130345456A1
Chemistry; metallurgy

Method for fractionating seeds

#5318
US20130345457A1
Chemistry; metallurgy

METHODS AND COMPOSITIONS FOR REFINING LIPID FEED STOCKS

#5319 ✅ Patent 9,139,770 granted on 2015-09-22
US20130345458A1
Chemistry; metallurgy

Silicone ligands for stabilizing quantum dot films

#5320 ✅ Patent 9,371,346 granted on 2016-06-21
US20130345459A1
Chemistry; metallurgy

Preparing a nickel phosphorus ligand complex

#5321 ✅ Patent 8,754,258 granted on 2014-06-17
US20130345460A1
Chemistry; metallurgy

Ferric organic compounds, uses thereof and methods of making same

#5322 ✅ Patent 9,212,193 granted on 2015-12-15
US20130345461A1
Chemistry; metallurgy

Amine-accelerated process for the surface treatment of colloidal silica and products thereof

#5323
US20130345462A1
Chemistry; metallurgy

PROCESS FOR PRODUCTION OF 4-OXOQUINOLINE COMPOUND

#5324 ✅ Patent 8,957,238 granted on 2015-02-17
US20130345463A1
Chemistry; metallurgy

Process for preparing malathion for pharmaceutical use

#5325 ✅ Patent 8,927,755 granted on 2015-01-06
US20130345464A1
Chemistry; metallurgy

I- and II-type crystals of L-alpha-glyceryl phosphoryl choline, and method for preparing same

#5326 ✅ Patent 9,102,593 granted on 2015-08-11
US20130345465A1
Chemistry; metallurgy

Process for the preparation of retigabine

#5327 ✅ Patent 8,969,367 granted on 2015-03-03
US20130345466A1
Chemistry; metallurgy

Crystalline forms of a 3-carboxypropyl-aminotetralin compound

#5328 ✅ Patent 9,018,408 granted on 2015-04-28
US20130345467A1
Chemistry; metallurgy

Processes for producing terephthalic acid and terephthalic esters

#5329 ✅ Patent 9,242,924 granted on 2016-01-26
US20130345468A1
Chemistry; metallurgy

Preparation of a 1-amino-3-hydroxy-cyclobutane-1-carboxylic acid derivative

#5330 ✅ Patent 9,018,256 granted on 2015-04-28
US20130345469A1
Human necessities

Feed additive for animals of P-thymol, salt derivative or ester derivative thereof

#5331
US20130345470A1
Chemistry; metallurgy

Purification of 3-Hydroxypropionic Acid from Crude Cell Broth and Production of Acrylamide

#5332
US20130345471A1
Chemistry; metallurgy

SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION

#5333 ✅ Patent 8,912,367 granted on 2014-12-16
US20130345472A1
Chemistry; metallurgy

Method and system for liquid phase reactions using high shear

#5334 ✅ Patent 9,487,465 granted on 2016-11-08
US20130345473A1
Chemistry; metallurgy

Process for the separation of mono- and di-carboxylic acid compounds

#5335 ✅ Patent 9,102,612 granted on 2015-08-11
US20130345474A1
Chemistry; metallurgy

Process for the production of acetic acid

#5336
US20130345475A1
Chemistry; metallurgy

PROCESS FOR THE RACEMIZATION OF OPTICALLY ACTIVE ARYLALKYLAMINES

#5337 ✅ Patent 10,358,404 granted on 2019-07-23
US20130345476A1
Chemistry; metallurgy

Process for the production of low molecular weight impact polyethers

#5338 ✅ Patent 9,029,613 granted on 2015-05-12
US20130345477A1
Chemistry; metallurgy

Alicyclic alcohol

#5339 ✅ Patent 9,024,087 granted on 2015-05-05
US20130345478A1
Chemistry; metallurgy

Process for making ethanol from acetic acid using acidic catalysts

#5340 ✅ Patent 8,785,700 granted on 2014-07-22
US20130345479A1
Chemistry; metallurgy

Alcohol concentration method

#5341 ✅ Patent 8,754,278 granted on 2014-06-17
US20130345480A1
Chemistry; metallurgy

Aromatic alkylation catalyst

#5342
US20130345481A1
Chemistry; metallurgy

Process for Producing Para-Xylene

#5343 ✅ Patent 9,156,028 granted on 2015-10-13
US20130345482A1
Chemistry; metallurgy

Alkylation process using phosphonium-based ionic liquids

#5344 ✅ Patent 9,156,747 granted on 2015-10-13
US20130345483A1
Chemistry; metallurgy

Alkylation process using phosphonium-based ionic liquids

#5345 ✅ Patent 9,399,604 granted on 2016-07-26
US20130345484A1
Chemistry; metallurgy

Alkylation process using phosphonium-based ionic liquids

#5346 ✅ Patent 9,676,684 granted on 2017-06-13
US20130345485A1
Chemistry; metallurgy

Process and unit for solvent recovery from solvent diluted tailings derived from bitumen froth treatment

#5347
US20130345486A1
Chemistry; metallurgy

RECOVERY OF BENZENE AND BENZENE DERIVATIVES FROM GASOLINE FRACTIONS AND REFINERY STREAMS

#5348 ✅ Patent 9,163,181 granted on 2015-10-20
US20130345487A1
Chemistry; metallurgy

Methods and apparatuses for deoxygenating biomass-derived pyrolysis oil

#5349
US20130345488A1
Human necessities

ORGANIC NITRATE EXPLOSIVE TREATMENT SYSTEM

#5350
US20130345489A1
Human necessities

CONFIGURATION MANAGEMENT AND RETRIEVAL SYSTEM FOR PROTON BEAM THERAPY SYSTEM

#5351 ✅ Patent 8,829,466 granted on 2014-09-09
US20130345490A1
Electricity

Particle beam irradiation apparatus and particle beam therapy system

#5352 ✅ Patent 9,993,655 granted on 2018-06-12
US20130345491A1
Human necessities

Image data processing device and transcranial magnetic stimulation apparatus

#5353 ✅ Patent 9,878,079 granted on 2018-01-30
US20130345492A1
Human necessities

Catheter device

#5354
US20130345493A1
Human necessities

CARDIAC SUPPORT SYSTEMS AND METHODS FOR CHRONIC USE

#5355 ✅ Patent 9,095,485 granted on 2015-08-04
US20130345494A1
Human necessities

Infant incubator

#5356 ✅ Patent 9,191,760 granted on 2015-11-17
US20130345495A1
Electricity

Optimal pre-load for floating mass transducers

#5357
US20130345496A1
Electricity

Bone Conduction Devices Generating Tangentially-Directed Mechanical Force Using a Rotationally Moving Mass

#5358 ✅ Patent 9,398,941 granted on 2016-07-26
US20130345497A1
Human necessities

Multi-compartment container for biological liquids

#5359 ✅ Patent 9,155,645 granted on 2015-10-13
US20130345498A1
Human necessities

Implantable prosthesis with radiopaque particles and method of making same

#5360
US20130345499A1
Human necessities

SIDE TO SIDE ANASTOMOSIS

#5361
US20130345500A1
Human necessities

REMOTELY ADJUSTABLE GASTRIC BANDING SYSTEM

#5362
US20130345501A1
Human necessities

Sexual Aid Device

#5363 ✅ Patent 8,968,184 granted on 2015-03-03
US20130345502A1
Human necessities

Endoscope apparatus, folder generating method, and non-transitory computer readable recording medium

#5364 ✅ Patent 10,588,490 granted on 2020-03-17
US20130345503A1
Human necessities

Hand-operated endoscope for medical purposes

#5365
US20130345504A1
Human necessities

REUSABLE IN-VIVO DEVICE, SYSTEM AND METHOD OF ASSEMBLY THEREOF

#5366 ✅ Patent 9,327,076 granted on 2016-05-03
US20130345505A1
Human necessities

Electronically and remotely controlled pill and system for delivering at least one medicament

#5367
US20130345506A1
Human necessities

MAGNETIC-CONTROLLED SYSTEM APPLICABLE FOR COLONOSCOPY

#5368 ✅ Patent 10,448,806 granted on 2019-10-22
US20130345507A1
Human necessities

Endoscope designs and methods of manufacture

#5369 ✅ Patent 8,926,500 granted on 2015-01-06
US20130345508A1
Human necessities

Light irradiating device, scanning endoscopic device, manufacturing method of light irradiating device, and manufacturing method of scanning endoscopic device

#5370
US20130345509A1
Human necessities

SYSTEM AND METHOD FOR ENDOSCOPIC MEASUREMENT AND MAPPING OF INTERNAL ORGANS, TUMORS AND OTHER OBJECTS

#5371
US20130345510A1
Human necessities

METHOD AND ENDOSCOPIC DEVICE FOR EXAMINING OR IMAGING AN INTERIOR SURFACE OF A CORPOREAL CAVITY

#5372 ✅ Patent 9,186,130 granted on 2015-11-17
US20130345511A1
Human necessities

Endoluminal system for gastrointestinal treatment

#5373 ✅ Patent 9,402,532 granted on 2016-08-02
US20130345512A1
Human necessities

Optical obturator

#5374 ✅ Patent 8,827,896 granted on 2014-09-09
US20130345513A1
Human necessities

Endoscope apparatus and medical system

#5375
US20130345514A1
Human necessities

PROPRIOCEPTIVE ENDOSCOPE AND VIRTUAL DYNAMIC TOMOGRAPHY

#5376 ✅ Patent 10,448,809 granted on 2019-10-22
US20130345515A1
Human necessities

Protective sheath for an endoscope

#5377
US20130345516A1
Human necessities

Shank for a flexible endoscope or a flexible endoscopic instrument

#5378
US20130345517A1
Human necessities

LIGHT SOURCE APPARATUS AND ENDOSCOPE SYSTEM

#5379 ✅ Patent 9,820,642 granted on 2017-11-21
US20130345518A1
Human necessities

Airway intubation device

#5380 ✅ Patent 8,932,211 granted on 2015-01-13
US20130345519A1
Human necessities

Floating, multi-lumen-catheter retractor system for a minimally-invasive, operative gastrointestinal treatment

#5381 ✅ Patent 9,095,301 granted on 2015-08-04
US20130345520A1
Human necessities

Minimal incision maximal access MIS spine instrumentation and method

#5382
US20130345521A1
Human necessities

DEVICE AND METHOD FOR ILLUMINATION OF VAGINAL FORNIX WITH URETER LOCATION, ISOLATION AND PROTECTION DURING HYSTERECTOMY PROCEDURE

#5383 ✅ Patent 8,903,483 granted on 2014-12-02
US20130345522A1
Human necessities

Devices and methods for monitoring physiological information relating to sleep with an implantable device

#5384
US20130345523A1
Human necessities

SIGNAL PROCESSING APPARATUS

#5385 ✅ Patent 9,171,131 granted on 2015-10-27
US20130345524A1
Physics

Device and methods for mobile monitoring and assessment of clinical function through sensors and interactive patient responses

#5386 ✅ Patent 9,320,465 granted on 2016-04-26
US20130345525A1
Human necessities

Bio-chips and nano-biochips

#5387
US20130345526A1
Human necessities

Automated Prevention and Control of Epileptic Seizures Using Biochemical And/or Electrical Signal Markers

#5388 ✅ Patent 9,370,321 granted on 2016-06-21
US20130345527A1
Human necessities

Ultrasound based antigen binding detection

#5389 ✅ Patent 8,792,952 granted on 2014-07-29
US20130345528A1
Human necessities

Sensor holder to be applied on an appendage of a subject

#5390
US20130345529A1
Human necessities

SHROUDED SENSOR CLIP ASSEMBLY AND BLOOD CHAMBER FOR AN OPTICAL BLOOD MONITORING SYSTEM

#5391 ✅ Patent 9,282,898 granted on 2016-03-15
US20130345530A1
Human necessities

End-to-end trusted communications infrastructure

#5392 ✅ Patent 8,886,271 granted on 2014-11-11
US20130345531A1
Human necessities

Non-invasive physiological sensor cover

#5393
US20130345532A1
Human necessities

MEDICAL VENTILATOR WITH INTEGRATED OXIMETER DATA

#5394
US20130345533A1
Human necessities

SENSOR FOR SCANNING VITAL TISSUE

#5395
US20130345534A1
Human necessities

Electrodes with Conductive Polymer Underlayer

#5396 ✅ Patent 9,456,761 granted on 2016-10-04
US20130345535A1
Human necessities

Current protection for electrode-based monitoring systems

#5397 ✅ Patent 8,974,397 granted on 2015-03-10
US20130345536A1
Human necessities

Dislocation sensor

#5398 ✅ Patent 10,016,145 granted on 2018-07-10
US20130345537A1
Human necessities

Far-field vs local activation discrimination on multi-electrode EGMS using vector analysis in multi-dimensional signal space

#5399 ✅ Patent 8,725,240 granted on 2014-05-13
US20130345538A1
Human necessities

Intracardiac tracking system

#5400 ✅ Patent 9,211,075 granted on 2015-12-15
US20130345539A1
Human necessities

Radiolucent electrode assembly