DOG DIABETES

Description

FIELD OF THE INVENTION

The present invention relates to the diagnosis and treatment of diabetes in animals.

BACKGROUND OF THE INVENTION

Use of an assay which identifies animals that are susceptible to diabetes would then allow such animals to be given therapy for diabetes.

SUMMARY OF THE INVENTION

The present inventors have identified polymorphism markers in animals which are associated with diabetes.

Accordingly, the invention provides a method for diagnosing susceptibility to diabetes in a non-human animal, the method comprising:

a) identifying whether or not a polymorphism as defined in Table 4 or a polymorphism which is in linkage disequilibrium with such a polymorphism is present in the genome of the animal; and

b) thereby diagnosing whether the animal is susceptible to diabetes,

wherein optionally the said identifying is carried out on a sample from the animal.

The invention further provides:

• • a probe, primer or antibody which is capable of detecting the polymorphisms;
  • a kit for carrying out the method of the invention comprising means for detecting the polymorphisms;
  • a method of preparing customised food for an animal which is susceptible to diabetes, the method comprising:

(a) determining whether the animal is susceptible to diabetes by a method of the invention; and

(b) preparing food suitable for the animal;

• • a database comprising information relating to polymorphisms and optionally their association with diabetes.

DESCRIPTION OF THE FIGURES

FIG. 1 shows odds ratio and confidence interval for protective and risk haplotypes in all dogs.

FIG. 2 shows percentage of dogs by risk group with DLA-DRB1*009 haplotypes.

FIG. 3 shows percentage of dogs by risk group with DLA-DQA1*004/DQB1*013 haplotypes.

FIG. 4 shows percentage of dogs by risk group with DLA-DQA1 alleles containing Arg 55.

FIG. 5 shows an apparatus of the invention.

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides a method for determining susceptibility to diabetes in an animal. The diabetes condition is normally one which is caused, at least partially, by an autoimmune mechanism.

The animal tested is typically a mammal, preferably a non-human animal, such as a dog, cat, horse, pig, cattle or sheep. The animal may be a companion animal or pet. In a preferred embodiment, the animal tested is a dog. The dog tested may be of any breed, or may be a mixed or crossbred dog, or an outbred dog (mongrel). The dog may be of any of the breeds mentioned herein.

The animal may be from 0 to 10 years old, for example from 0 to 5 years old, from 0 to 3 years old or from 0 to 2 years old. When the method of the invention is carried out on a sample from the animal, the sample may have been taken from an animal within any of these age ranges. The animal may be tested by the method of the invention before any symptoms of diabetes are apparent.

A dog of any breed may be tested by a method of the present invention. The table below provides examples of dog breeds, wherein S=small, M=medium, L=large and XL=extra large.

	Breed	Size

a) Hounds

	Afghan Hound	L
	Basenji	M
	Basset Bleu De Gascogne	M
	Basset Fauve De Bretagne	M
	Basset Griffon Vendeen (Grand)	M
	Basset Griffon Vendeen (Petit)	M
	Basset Hound	M
	Bavarian Mountain Hound	M
	Beagle	M
	Bloodhound	L
	Borzoi	L
	Dachshund	M
	Dachshund (Long Haired)	M
	Dachshund (Miniature Long Haired)	S
	Dachshund (Short Haired)	M
	Dachshund (Smooth Haired)	M
	Dachshund (Miniature Smooth Haired)	S
	Dachshund (Wire Haired)	M
	Dachshund (Miniature Wire Haired)	S
	Deerhound	L
	Norwegian Elkhound	L
	Finnish Spitz	M
	Foxhound	L
	Grand Bleu De Gascogne	L
	Greyhound	L
	Hamiltonstovare	L
	Ibizan Hound	L
	Irish Wolfhound	XL
	Norwegian Lundehund	M
	Otterhound	L
	Pharaoh Hound	L
	Rhodesian Ridgeback	L
	Saluki	L
	Segugio Italiano	L
	Sloughi	L
	Whippet	M

b) Working Dogs

	Alaskan Malamute	L
	Beauceron	L
	Bernese Mountain Dog	XL
	Bouvier Des Flandres	L
	Boxer	L
	Bullmastiff	L
	Canadian Eskimo Dog	L
	Dobermann	L
	Dogue de Bordeaux	L
	German Pinscher	M
	Greenland Dog	L
	Giant Schnauzer	L
	Great Dane	XL
	Hovawart	L
	Leonberger	XL
	Mastiff	XL
	Neapolitan Mastiff	XL
	Newfoundland	XL
	Portuguese Water Dog	L
	Rottweiler	L
	Russian Black Terrier	L
	St. Bernard	XL
	Siberian Husky	L
	Tibetan Mastiff	XL

c) Terrier

	Airedale Terrier	L
	Australian Terrier	S
	Bedlington Terrier	M
	Border Terrier	S
	Bull Terrier	M
	Bull Terrier (Miniature)	M
	Cairn Terrier	S
	Cesky Terrier	M
	Dandie Dinmont Terrier	M
	Fox Terrier (Smooth)	M
	Fox Terrier (Wire)	M
	Glen of Imaal Terrier	M
	Irish Terrier	M
	Jack Russell Terrier	M
	Kerry Blue Terrier	M
	Lakeland Terrier	M
	Manchester Terrier	M
	Norfolk Terrier	S
	Norwich Terrier	S
	Parson Russell Terrier	M
	Scottish Terrier	M
	Sealyham Terrier	M
	Skye Terrier	M
	Soft Coated Wheaten Terrier	M
	Staffordshire Bull Terrier	M
	Welsh Terrier	M
	West Highland White Terrier	S

d) Gundogs (Sporting Group)

	Bracco Italiano	L
	Brittany	M
	English Setter	L
	German Longhaired Pointer	L
	German Shorthaired Pointer	L
	German Wirehaired Pointer	L
	Gordon Setter	L
	Hungarian Vizsla	L
	Hungarian Wirehaired Vizsla	L
	Irish Red and White Setter	L
	Irish Setter	L
	Italian Spinone	L
	Kooikerhondje	M
	Lagotto Romagnolo	M
	Large Munsterlander	L
	Nova Scotia Duck Tolling Retriever	M
	Pointer	L
	Retriever (Chesapeake Bay)	L
	Retriever (Curly Coated)	L
	Retriever (Flat Coated)	L
	Retriever (Golden)	L
	Retriever (Labrador)	L
	Spaniel (American Cocker)	M
	Spaniel (American Water)	M
	Spaniel (Clumber)	L
	Spaniel (Cocker)	M
	Spaniel (English Cocker)	M
	Spaniel (English Springer)	M
	Spaniel (Field)	M
	Spaniel (Irish Water)	M
	Spaniel (Sussex)	M
	Spaniel (Welsh Springer)	M
	Spanish Water Dog	M
	Vizsla	M
	Weimaraner	L

e) Pastoral (Herding Group)

	Anatolian Shepherd Dog	L
	Australian Cattle Dog	M
	Australian Shepherd	L
	Bearded Collie	L
	Belgian Shepherd Dog (Groenendael)	L
	Belgian Shepherd Dog (Malinois)	L
	Belgian Shepherd Dog (Laekenois)	L
	Belgian Shepherd Dog (Tervueren)	L
	Bergamasco	L
	Border Collie	M
	Briard	L
	Collie (Rough)	L
	Collie (Smooth)	L
	Estrela Mountain Dog	XL
	Finnish Lapphund	M
	German Shepherd Dog (Alsatian)	L
	Hungarian Kuvasz	L
	Hungarian Puli	M
	Komondor	L
	Lancashire Heeler	S
	Maremma Sheepdog	L
	Norwegian Buhund	M
	Old English Sheepdog	L
	Polish Lowland Sheepdog	M
	Pyrenean Mountain Dog	XL
	Pyrenean Sheepdog	M
	Samoyed	L
	Shetland Sheepdog	M
	Swedish Lapphund	M
	Swedish Vallhund	M
	Welsh Corgi (Cardigan)	M
	Welsh Corgi (Pembroke)	M

f) Utility Dogs (Non-sporting)

	Akita	L
	American Eskimo	M
	Boston Terrier	S
	Bulldog	M
	Canaan Dog	L
	Chow Chow	L
	Dalmatian	L
	French Bulldog	S
	German Spitz (Klein)	S
	German Spitz (Mittel)	M
	Japanese Shiba Inu	M
	Japanese Spitz	M
	Keeshond	M
	Lhasa Apso	S
	Mexican Hairless	M
	Miniature Schnauzer	S
	Poodle (Miniature)	M
	Poodle (Standard)	L
	Poodle (Toy)	S
	Schipperke	S
	Schnauzer (Standard)	M
	Shar Pei	M
	Shih Tzu	S
	Tibetan Spaniel	S
	Tibetan Terrier	M

g) Toy Dogs

	Affenpinscher	S
	Australian Silky Terrier	S
	Bichon Frise	S
	Bolognese	S
	Cavalier King Charles Spaniel	S
	Chihuahua (Long Coat)	S
	Chihuahua (Smooth Coat)	S
	Chinese Crested	S
	Coton De Tulear	S
	English Toy Terrier (Black and Tan)	S
	Griffon Bruxellios	S
	Havanese	S
	Italian Greyhound	S
	Japanese Chin	S
	King Charles Spaniel	S
	Lowchen (Little Lion Dog)	S
	Maltese	S
	Miniature Pinscher	S
	Papillon	S
	Pekingese	S
	Pomeranian	S
	Pug	S
	Silky Terrier	S
	Toy Fox Terrier	S
	Yorkshire Terrier	S

In a preferred embodiment the dog to be tested is a dog which is of a breed mentioned in Table 1 or Table 3. In particular the dog may be of any of the following breeds: Samoyed, Tibetan Terrier, Bichon Frise, Yorkshire Terrier, Schnauzer (miniature), Border Collie, Dachshund, Border Terrier or Poodle; or a dog that is genetically related to any of these breeds. Preferably the dog to be tested is a pure bred. However, in one embodiment, the dog to be tested may have at least 50% of any of the breeds mentioned herein. In another embodiment, the dog may have at least 75% of any of the breeds mentioned herein in its genetic bred background. Thus, at least 50% or at least 75% of its genome may be derived from any of the breeds mentioned herein. In one embodiment, the dog may have a parent or grandparent which is of any of the breeds mentioned herein. The genetic breed background of a dog may be determined by detecting the presence or absence of two or more breed-specific SNP markers in the dog.

Detection of Polymorphisms

The detection of polymorphisms according to the invention may comprise contacting a polynucleotide or protein of the animal with a specific binding agent for a polymorphism and determining whether the agent binds to the polynucleotide or protein, wherein binding of the agent indicates the presence of the polymorphism, and lack of binding of the agent indicates the absence of the polymorphism.

The method is generally carried out in vitro on a sample from the animal. The sample typically comprises a body fluid and/or cells of the individual and may, for example, be obtained using a swab, such as a mouth swab. The sample may be a blood, urine, saliva, skin, cheek cell or hair root sample. The sample is typically processed before the method is carried out, for example DNA extraction may be carried out. The polynucleotide or protein in the sample may be cleaved either physically or chemically, for example using a suitable enzyme. In one embodiment the part of polynucleotide in the sample is copied or amplified, for example by cloning or using a PCR based method prior to detecting the polymorphism.

In the present invention, any one or more methods may comprise determining the presence or absence of one or more polymorphisms in the animal. The polymorphism is typically detected by directly determining the presence of the polymorphic sequence in a polynucleotide or protein of the animal. Such a polynucleotide is typically genomic DNA, mRNA or cDNA. The polymorphism may be detected by any suitable method such as those mentioned below.

A specific binding agent is an agent that binds with preferential or high affinity to the protein or polypeptide having the polymorphism but does not bind or binds with only low affinity to other polypeptides or proteins. The specific binding agent may be a probe or primer. The probe may be a protein (such as an antibody) or an oligonucleotide. The probe may be labelled or may be capable of being labelled indirectly. The binding of the probe to the polynucleotide or protein may be used to immobilise either the probe or the polynucleotide or protein.

Generally in the method, determination of the binding of the agent to the polymorphism can be carried out by determining the binding of the agent to the polynucleotide or protein of the animal. However in one embodiment the agent is also able to bind the corresponding wild-type sequence, for example by binding the nucleotides or amino acids which flank the polymorphism position, although the manner of binding to the wild-type sequence will be detectably different to the binding of a polynucleotide or protein containing the polymorphism.

The method may be based on an oligonucleotide ligation assay in which two oligonucleotide probes are used. These probes bind to adjacent areas on the polynucleotide which contains the polymorphism, allowing after binding the two probes to be ligated together by an appropriate ligase enzyme. However the presence of single mismatch within one of the probes may disrupt binding and ligation. Thus ligated probes will only occur with a polynucleotide that contains the polymorphism, and therefore the detection of the ligated product may be used to determine the presence of the polymorphism.

In one embodiment the probe is used in a heteroduplex analysis based system. In such a system when the probe is bound to polynucleotide sequence containing the polymorphism it forms a heteroduplex at the site where the polymorphism occurs and hence does not form a double strand structure. Such a heteroduplex structure can be detected by the use of single or double strand specific enzyme. Typically the probe is an RNA probe, the heteroduplex region is cleaved using RNAase H and the polymorphism is detected by detecting the cleavage products.

The method may be based on fluorescent chemical cleavage mismatch analysis which is described for example in PCR Methods and Applications 3, 268-71 (1994) and Proc. Natl. Acad. Sci. 85, 4397-4401 (1998).

In one embodiment a PCR primer is used that primes a PCR reaction only if it binds a polynucleotide containing the polymorphism, for example a sequence- or allele-specific PCR system, and the presence of the polymorphism may be determined by the detecting the PCR product. Preferably the region of the primer which is complementary to the polymorphism is at or near the 3′ end of the primer. The presence of the polymorphism may be determined using a fluorescent dye and quenching agent-based PCR assay such as the Taqman PCR detection system. The specific binding agent may be capable of specifically binding the amino acid sequence encoded by a variant sequence. For example, the agent may be an antibody or antibody fragment. The detection method may be based on an ELISA system. The method may be an RFLP based system. This can be used if the presence of the polymorphism in the polynucleotide creates or destroys a restriction site that is recognised by a restriction enzyme.

The presence of the polymorphism may be determined based on the change which the presence of the polymorphism makes to the mobility of the polynucleotide or protein during gel electrophoresis. In the case of a polynucleotide single-stranded conformation polymorphism (SSCP) or denaturing gradient gel electrophoresis (DDGE) analysis may be used.

The presence of the polymorphism may be detected by means of fluorescence resonance energy transfer (FRET). In particular, the polymorphism may be detected by means of a dual hybridisation probe system. This method involves the use of two oligonucleotide probes that are located close to each other and that are complementary to an internal segment of a target polynucleotide of interest, where each of the two probes is labelled with a fluorophore. Any suitable fluorescent label or dye may be used as the fluorophore, such that the emission wavelength of the fluorophore on one probe (the donor) overlaps the excitation wavelength of the fluorophore on the second probe (the acceptor). A typical donor fluorophore is fluorescein (FAM), and typical acceptor fluorophores include Texas red, rhodamine, LC-640, LC-705 and cyanine 5 (Cy5).

In order for fluorescence resonance energy transfer to take place, the two fluorophores need to come into close proximity on hybridisation of both probes to the target. When the donor fluorophore is excited with an appropriate wavelength of light, the emission spectrum energy is transferred to the fluorophore on the acceptor probe resulting in its fluorescence. Therefore, detection of this wavelength of light, during excitation at the wavelength appropriate for the donor fluorophore, indicates hybridisation and close association of the fluorophores on the two probes. Each probe may be labelled with a fluorophore at one end such that the probe located upstream (5′) is labelled at its 3′ end, and the probe located downstream (3′) is labelled at is 5′ end. The gap between the two probes when bound to the target sequence may be from 1 to 20 nucleotides, preferably from 1 to 17 nucleotides, more preferably from 1 to 10 nucleotides, such as a gap of 1, 2, 4, 6, 8 or 10 nucleotides.

The first of the two probes may be designed to bind to a conserved sequence of the gene adjacent to a polymorphism and the second probe may be designed to bind to a region including one or more polymorphisms. Polymorphisms within the sequence of the gene targeted by the second probe can be detected by measuring the change in melting temperature caused by the resulting base mismatches. The extent of the change in the melting temperature will be dependent on the number and base types involved in the nucleotide polymorphisms.

The polymorphic position may be typed directly, in other words by determining the nucleotide present at that position, or indirectly, for example by determining the nucleotide present at another polymorphic position that is in linkage disequilibrium with said polymorphic position.

Polymorphisms which are in linkage disequilibrium with each other in a population are typically found together on the same chromosome. Typically one is found at least 30% of the times, for example at least 40%, at least 50%, at least 70% or at least 90%, of the time the other is found on a particular chromosome in individuals in the population. Thus a polymorphism which is not a functional susceptibility polymorphism, but is in linkage disequilibrium with a functional polymorphism, may act as a marker indicating the presence of the functional polymorphism.

Polymorphisms which are in linkage disequilibrium with the polymorphisms mentioned herein are typically located within 500 kb, preferably within 400 kb, within 200 kb, within 100 kb, within 50 kb, within 10 kb, within 5 kb, within 1 kb, within 500 bp, within 100 bp, within 50 bp or within 10 bp of the polymorphism.

A polynucleotide of the invention may be used as a primer, for example for PCR, or a probe. A polynucleotide or polypeptide of the invention may carry a revealing label. Suitable labels include radioisotopes such as ³²P or ³⁵S, fluorescent labels, enzyme labels or other protein labels such as biotin.

Polynucleotides of the invention may be used as a probe or primer which is capable of selectively binding to a polymorphism. The invention thus provides a probe or primer for use in a method according to the invention, which probe or primer is capable of selectively detecting the presence of a polymorphism. Preferably the probe is isolated or recombinant nucleic acid. The probe may be immobilised on an array, such as a polynucleotide array.

Such primers, probes and other fragments will preferably be at least 10, preferably at least 15 or at least 20, for example at least 25, at least 30 or at least 40 nucleotides in length. They will typically be up to 40, 50, 60, 70, 100 or 150 nucleotides in length. Probes and fragments can be longer than 150 nucleotides in length, for example up to 200, 300, 400, 500, 600, 700 nucleotides in length, or even up to a few nucleotides, such as five or ten nucleotides, short of a full length polynucleotide sequence of the invention.

Polypeptides of the invention may be chemically modified, for example post-translationally modified. The polypeptides may be glycosylated or comprise modified amino acid residues. Such modified polypeptides fall within the scope of the term “polypeptide” of the invention.

The polypeptides (e.g. antibodies) and polynucleotides (e.g. primer and probes) of the invention may be present in an isolated or substantially purified form. They may be mixed with carriers or diluents which will not interfere with their intended use and still be regarded as substantially isolated. They may also be in a substantially purified form, in which case they will generally comprise at least 90%, e.g. at least 95%, 98% or 99%, of the proteins or polynucleotides or dry mass of the preparation.

In the method of the invention the presence or absence of the alleles mentioned in Table 4 may be detected by any suitable means. Typically in the method one or more of the polymorphisms listed in Table 4 is typed. Thus, the presence or absence of the polymorphism may be determined, typically in a polynucleotide from the dog, to ascertain whether or not the genome of the dog comprises the relevant polymorphism. In one embodiment, whether or not the genome of the dog comprises all of the polymorphisms listed a row of Table 4 is acertained. Thus for example, the method may comprise determining the presence or absence of 96C, 126A and 254G as shown in the top row of polymorphisms in Table 4. In a preferred embodiment, at least 5, at least 15 or at least 20 of the polymorphisms shown in Table 4 are typed in the method of the invention. In one embodiment, a polymorphism which is in linkage to disequilibrium with a polymorphism shown in Table 4 is typed (in order to acesertain the presence of a polymorphism in Table 4 in the genome of the dog). In one embodiment, whether or not the polymorphisms which are typed are present on the same DNA strand is also determined.

Detector Antibodies

The invention also provides detector antibodies that are specific for a polypeptide of the invention. A detector antibody is specific for one polymorphism, for example. The detector antibodies of the invention are for example useful in purification, isolation or screening methods involving immunoprecipitation techniques.

Antibodies may be raised against specific epitopes of the polypeptides of the invention. An antibody, or other compound, “specifically binds” to a polypeptide when it binds with preferential or high affinity to the protein for which it is specific but does substantially bind not bind or binds with only low affinity to other polypeptides. A variety of protocols for competitive binding or immunoradiometric assays to determine the specific binding capability of an antibody are well known in the art (see for example Maddox et al, J. Exp. Med. 158, 1211-1226, 1993). Such immunoassays typically involve the formation of complexes between the specific protein and its antibody and the measurement of complex formation.

For the purposes of this invention, the term “antibody”, unless specified to the contrary, includes fragments which bind a polypeptide of the invention. Such fragments include Fv, F(ab′) and F(ab′)₂ fragments, as well as single chain antibodies. Furthermore, the antibodies and fragment thereof may be chimeric antibodies, CDR-grafted antibodies or humanised antibodies.

Antibodies may be used in a method for detecting polypeptides of the invention in a biological sample (such as any such sample mentioned herein), which method comprises:

• I providing an antibody of the invention;
• II incubating a biological sample with said antibody under conditions which allow for the formation of an antibody-antigen complex; and
• III determining whether antibody-antigen complex comprising said antibody is formed.

Antibodies of the invention can be produced by any suitable method. Means for preparing and characterising antibodies are well known in the art, see for example Harlow and Lane (1988) “Antibodies: A Laboratory Manual”, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. For example, an antibody may be produced by raising antibody in a host animal against the whole polypeptide or a fragment thereof, for example an antigenic epitope thereof, herein after the “immunogen”. The fragment may be any of the fragments mentioned herein (typically at least 10 or at least 15 amino acids long).

A method for producing a polyclonal antibody comprises immunising a suitable host animal, for example an experimental animal, with the immunogen and isolating immunoglobulins from the animal's serum. The animal may therefore be inoculated with the immunogen, blood subsequently removed from the animal and the IgG fraction purified. A method for producing a monoclonal antibody comprises immortalising cells which produce the desired antibody. Hybridoma cells may be produced by fusing spleen cells from an inoculated experimental animal with tumour cells (Kohler and Milstein (1975) Nature 256, 495-497).

An immortalized cell producing the desired antibody may be selected by a conventional procedure. The hybridomas may be grown in culture or injected intraperitoneally for formation of ascites fluid or into the blood stream of an allogenic host or immunocompromised host. Human antibody may be prepared by in vitro immunisation of human lymphocytes, followed by transformation of the lymphocytes with Epstein-Barr virus.

For the production of both monoclonal and polyclonal antibodies, the experimental animal is suitably a goat, rabbit, rat, mouse, guinea pig, chicken, sheep or horse. If desired, the immunogen may be administered as a conjugate in which the immunogen is coupled, for example via a side chain of one of the amino acid residues, to a suitable carrier. The carrier molecule is typically a physiologically acceptable carrier. The antibody obtained may be isolated and, if desired, purified.

Detection Kit

The invention also provides a kit that comprises means for determining the presence or absence of one or more polymorphisms in an animal which are associated with susceptibility to diabetes. In particular, such means may include a specific binding agent, probe, primer, pair or combination of primers, or antibody, including an antibody fragment, as defined herein which is capable of detecting or aiding detection of a polymorphism. The primer or pair or combination of primers may be sequence specific primers which only cause PCR amplification of a polynucleotide sequence comprising the polymorphism to be detected, as discussed herein. The kit may also comprise a specific binding agent, probe, primer, pair or combination of primers, or antibody which is capable of detecting the absence of the polymorphism. The kit may further comprise buffers or aqueous solutions.

The kit may additionally comprise one or more other reagents or instruments which enable any of the embodiments of the method mentioned above to be carried out. Such reagents or instruments may include one or more of the following: a means to detect the binding of the agent to the polymorphism, a detectable label such as a fluorescent label, an enzyme able to act on a polynucleotide, typically a polymerase, restriction enzyme, ligase, RNAse H or an enzyme which can attach a label to a polynucleotide, suitable buffer(s) or aqueous solutions for enzyme reagents, PCR primers which bind to regions flanking the polymorphism as discussed herein, a positive and/or negative control, a gel electrophoresis apparatus, a means to isolate DNA from sample, a means to obtain a sample from the individual, such as swab or an instrument comprising a needle, or a support comprising wells on which detection reactions can be carried out. The kit may be, or include, an array such as a polynucleotide array comprising the specific binding agent, preferably a probe, of the invention. The kit typically includes a set of instructions for using the kit.

Screening for Therapeutic Agents

The present invention also relates to the use of polypeptides encoded by the polymorphic sequence as a screening target for identifying therapeutic agents for the treatment of diabetes. In one embodiment the invention provides a method for identifying an agent useful for the treatment of diabetes, which method comprises contacting the polypeptide with a test agent and determining whether the agent is capable of binding to the polypeptide or modulating the activity or expression of the polypeptide. Any suitable binding assay format can be used to determine whether the polypeptide binds the test agent, such as the formats discussed below.

The method may be carried out in vitro, either inside or outside a cell, or in vivo. In one embodiment the method is carried out on a cell, cell culture or cell extract that comprises the polypeptide.

The method may also be carried out in vivo in an non-human animal which is transgenic for a polymorphism as defined herein. The transgenic non-human animal is typically of a species commonly used in biomedical research and is preferably a laboratory strain. Suitable animals include rodents, particularly a mouse, rat, guinea pig, ferret, gerbil or hamster. Most preferably the animal is a mouse.

Suitable candidate agents which may be tested in the above screening methods include antibody agents, for example monoclonal and polyclonal antibodies, single chain antibodies, chimeric antibodies and CDR-grafted antibodies. Furthermore, combinatorial libraries, defined chemical identities, peptide and peptide mimetics, oligonucleotides and natural agent libraries, such as display libraries may also be tested. The test agents may be chemical compounds, which are typically derived from synthesis around small molecules which may have any of the properties of the agent mentioned herein. Batches of the candidate agents may be used in an initial screen of, for example, ten substances per reaction, and the substances of batches which show modulation tested individually. The term ‘agent’ is intended to include a single substance and a combination of two, three or more substances. For example, the term agent may refer to a single peptide, a mixture of two or more peptides or a mixture of a peptide and a defined chemical entity. In one aspect of the invention, the test agent is a food ingredient.

Treatment of Diabetes

The invention provides a method of treating an animal for diabetes. The method comprising identifying an animal which is susceptible to diabetes by the above-described method, and administering to the animal an effective amount of a therapeutic agent which treats diabetes. The therapeutic agent may be any drug known in the art that may be used to treat diabetes, or may an agent identified by a screening method as discussed previously.

The therapeutic agent may be administered in various manners such as orally, intracranially, intravenously, intramuscularly, intraperitoneally, intranasally, intrademally, and subcutaneously. The pharmaceutical compositions that contain the therapeutic agent will normally be formulated with an appropriate pharmaceutically acceptable carrier or diluent depending upon the particular mode of administration being used. For instance, parenteral formulations are usually injectable fluids that use pharmaceutically and physiologically acceptable fluids such as physiological saline, balanced salt solutions, or the like as a vehicle. Oral formulations, on the other hand, may be solids, for example tablets or capsules, or liquid solutions or suspensions.

The amount of therapeutic agent that is given to an animal will depend upon a variety of factors including the condition being treated, the nature of the animal under treatment and the severity of the condition under treatment. A typical daily dose is from about 0.1 to 50 mg per kg, preferably from about 0.1 mg/kg to 10 mg/kg of body weight, according to the activity of the specific inhibitor, the age, weight and conditions of the animal to be treated, the type and severity of the disease and the frequency and route of administration. Preferably, daily dosage levels are from 5 mg to 2 g.

Customised Food

In one aspect, the invention relates to a customised diet for an animal that is susceptible to diabetes. In a preferred embodiment, the customised food is for a companion animal or pet, such as a dog. Such a food may be in the form of, for example, wet pet foods, semi-moist pet foods, dry pet foods and pet treats. Wet pet food generally has a moisture content above 65%. Semi-moist pet food typically has a moisture content between 20-65% and can include humectants and other ingredients to prevent microbial growth. Dry pet food, also called kibble, generally has a moisture content below 20% and its processing typically includes extruding, drying and/or baking in heat. The ingredients of a dry pet food generally include cereal, grains, meats, poultry, fats, vitamins and minerals. The ingredients are typically mixed and put through an extruder/cooker. The product is then typically shaped and dried, and after drying, flavours and fats may be coated or sprayed onto the dry product.

Accordingly, the present invention enables the preparation of customised food suitable for an animal which is susceptible to diabetes, wherein the customised animal food formulation comprises ingredients that prevent or alleviate diabetes (for example, in an increased amount), and/or does not comprise components that contribute to or aggravate diabetes or comprises components that contribute to or aggravate diabetes in a reduced amount. Such ingredients may be any of those known in the art to prevent or alleviate diabetes, such as insulin. Alternatively, screening methods as discussed herein may identify such ingredients. The preparation of customised animal food may be carried out by electronic means, for example by using a computer system.

In another embodiment, the customised food may be formulated to include functional or active ingredients that help prevent or alleviate diabetes.

The present invention also relates to a method of providing a customised animal food, comprising providing food suitable for an animal which is susceptible to diabetes to the animal, the animal's owner or the person responsible for feeding the animal, wherein the animal has been determined to be susceptible to diabetes by a method of the invention. In one aspect of the invention, the customised food is made to inventory and supplied from inventory, i.e. the customised food is pre-manufactured rather than being made to order. Therefore according this aspect of the invention the customised food is not specifically designed for one particular animal but instead is suitable for more than one animal. For example, the customised food may be suitable for any animal that is susceptible to diabetes. Alternatively, the customised food may be suitable for a sub-group of animals that are susceptible to diabetes, such as animals of a particular breed, size or lifestage. In another embodiment, the food may be customised to meet the nutritional requirements of an individual animal.

Bioinformatics

The sequences of the polymorphisms may be stored in an electronic format, for example in a computer database. Accordingly, the invention provides a database comprising information relating to polymorphismsequences. The database may include further information about the polymorphism, for example the level of association of the polymorphism with diabetes or the frequency of the polymorphism in the population. In one aspect of the invention, the database further comprises information regarding the food components which are suitable and the food components which are not suitable for animals who possess a particular polymorphism.

A database as described herein may be used to determine the susceptibility of an animal to diabetes. Such a determination may be carried out by electronic means, for example by using a computer system (such as a PC). Typically, the determination will be carried out by inputting genetic data from the animal to a computer system; comparing the genetic data to a database comprising information relating to polymorphisms; and on the basis of this comparison, determining the susceptibility of the animal to diabetes.

The invention also provides a computer program comprising program code means for performing all the steps of a method of the invention when said program is run on a computer. Also provided is a computer program product comprising program code means stored on a computer readable medium for performing a method of the invention when said program is run on a computer. A computer program product comprising program code means on a carrier wave that, when executed on a computer system, instruct the computer system to perform a method of the invention is additionally provided.

As illustrated in FIG. 5, the invention also provides an apparatus arranged to perform a method according to the invention. The apparatus typically comprises a computer system, such as a PC. In one embodiment, the computer system comprises: means 20 for receiving genetic data from the animal; a module 30 for comparing the data with a database 10 comprising information relating to polymorphisms; and means 40 for determining on the basis of said comparison the susceptibility of the animal to diabetes.

Food Manufacturing

In one embodiment of the invention, the manufacture of a customised animal food may be controlled electronically. Typically, information relating to the polymorphism present in an animal may be processed electronically to generate a customised animal food formulation. The customised animal food formulation may then be used to generate electronic manufacturing instructions to control the operation of food manufacturing apparatus. The apparatus used to carry out these steps will typically comprise a computer system, such as a PC, which comprises means 50 for processing the nutritional information to generate a customised animal food formulation; means 60 for generating electronic manufacturing instructions to control the operation of food manufacturing apparatus; and a food product manufacturing apparatus 70.

The food product manufacturing apparatus used in the present invention typically comprises one or more of the following components: container for dry pet food ingredients; container for liquids; mixer; former and/or extruder; cut-off device; cooking means (e.g. oven); cooler; packaging means; and labelling means. A dry ingredient container typically has an opening at the bottom. This opening may be covered by a volume-regulating element, such as a rotary lock. The volume-regulating element may be opened and closed according to the electronic manufacturing instructions to regulate the addition of dry ingredients to the pet food.

Dry ingredients typically used in the manufacture of pet food include corn, wheat, meat and/or poultry meal. Liquid ingredients typically used in the manufacture of pet food include fat, tallow and water. A liquid container may contain a pump that can be controlled, for example by the electronic manufacturing instructions, to add a measured amount of liquid to the pet food.

In one embodiment, the dry ingredient container(s) and the liquid container(s) are coupled to a mixer and deliver the specified amounts of dry ingredients and liquids to the mixer. The mixer may be controlled by the electronic manufacturing instructions. For example, the duration or speed of mixing may be controlled. The mixed ingredients are typically then delivered to a former or extruder. The former/extruder may be any former or extruder known in the art that can be used to shape the mixed ingredients into the required shape. Typically, the mixed ingredients are forced through a restricted opening under pressure to form a continuous strand. As the strand is extruded, it may be cut into pieces (kibbles) by a cut-off device, such as a knife. The kibbles are typically cooked, for example in an oven. The cooking time and temperature may be controlled by the electronic manufacturing instructions. The cooking time may be altered in order to produce the desired moisture content for the food. The cooked kibbles may then be transferred to a cooler, for example a chamber containing one or more fans.

The food manufacturing apparatus may comprise a packaging apparatus. The packaging apparatus typically packages the food into a container such as a plastic or paper bag or box. The apparatus may also comprise means for labelling the food, typically after the food has been packaged. The label may provide information such as: ingredient list; nutritional information; date of manufacture; best before date; weight; and species and/or breed(s) for which the food is suitable.

The invention is illustrated by the following Examples:

EXAMPLES

Materials and Methods

Control DNA samples were obtained from residual blood samples taken for diagnostic clinical purposes at the Small Animal Hospital, University of Liverpool. Table 1 shows the breed distribution of the 460 diabetics, 1047 controls and 69 female entire diabetics.

All the dogs were characterised for three DLA class II loci using either sequence based typing (SBT) (Kennedy et al Tissue Antigens 60: 43-52, 2002; Kennedy et al Immunogenetics 48: 296-301, 1998) or Reference Strand-mediated Conformation Analysis (RSCA).

All PCR reactions are performed with 25 ng DNA in a 25 μl reaction containing 1×PCR buffer as supplied by Qiagen (with no extra magnesium), Q solution (Qiagen), final concentrations of 0.1 μM for each primer, 200 μM each dNTP, with 2 units of Taq polymerase, (Qiagen HotStarTaq). A negative control containing no DNA template should be included in each run of amplifications to identify any contamination.

Primers used were: DRBF forward: gat ccc ccc gtc ccc aca g, DRBR3 reverse: cgc ccg ctg cgc tca, DQAin1 forward: taa ggt tct ttt etc cct ct, DQAIn2 reverse: gga cag att cag tga aga ga, DQB1B forward: ctc act ggc ccg get gtc tc and DQBR2 reverse: cac etc gcc get gca acg tg. All primers are intronic and locus specific, and the product sizes are 303 bp for DLA-DRB1, 345 bp for DQA1 and 300 bp for DQB1.

A standard Touchdown PCR protocol was used for all amplifications, which consisted of an initial 15 minutes at 95° C., 14 touch down cycles of 95° C. for 30 seconds, followed by 1 minute annealing, starting at 62° C. (DRB1), 54° C. (DQA1) 73° C. (DQB1) and reducing by 0.5° C. each cycle, and 72° C. for 1 minute. Then 20 cycles of 95° C. for 30 seconds, 55° C. (DRB1), 47° C. (DQA1) 66° C. (DQB1) for 1 minute, 72° C. for 1 minute plus a final extension at 72° C. for 10 minutes.

To check for the presence of a product, 5 μl was run on a 2% agarose gel. No purification was required for RSCA. However, this was required SBT: 2 units of shrimp alkaline phosphatase (USB) and 10 units of Exol (New England Biolabs) were added to 5 μl of PCR product. The mixture was incubated for 1 hour at 37° C., then for 15 minutes at 80° C.

RSCA: FLRs were generated, using a range of DLA-DRB1 alleles from the domestic dog and grey wolf. The FLRs were produced by PCR using cloned alleles as templates and a 5′-FAM22 labelled forward primer. In order to increase the proportion of the labelled reference strand in the reaction, the primer proportions were altered to 0.5 μM FAM22-labelled forward primer and 0.1 μM reverse unlabelled primer. All other aspects of the PCR reaction remained the same. This single stranded-biased FLR was used to increase the heights of the FLR-allele heteroduplex peaks relative to the homoduplex peaks in subsequent RSCA. All the resulting FLRs were diluted 1:30 in water before use in the hybridisation reactions.

In order to form duplexes between test samples and FLRs, 2 μl of diluted FLR and 2 μl of test sample PCR product were mixed in a 96 well plate and incubated in a thermal cycler at 95° C. for 10 minutes, ramped down to 55° C. at 1° C./second, 55° C. for 15 minutes and 4° C. for 15 minutes. The plate was stored at 4° C. until required. Subsequently, 8 μl distilled water were added to each hybridisation reaction, and then 2 μl were mixed with 4.8 μl water and 0.2 μl Genescan Rox-500 size standards (Applied Biosystems), in a 384 well plate. These samples were run on an ABI 3100 DNA analyser, using 50 cm capillary arrays, 4% Genescan non-denaturing polymer (Applied Biosystems) and data collected using matrix Dye set D. The conditions were: injection voltage 15 kV, injection time 15 seconds, run voltage 15 kV, run temperature 30° C. Each run took 35 minutes. The data were analysed using software programs “Genescan” and “Genotyper” (Applied Biosystems). Genescan was used to assign sizes to each peak, based on the ROX-500 standards. Using Genotyper, allele peaks formed by the control samples were assigned to “bins” for each FLR used. The bins were exported to a program which assigned the alleles for each sample.

Three-locus, DLA-DRB1/DQA1/DQB1, haplotypes were identified by following a sequential analytical process. Firstly, all dogs that were homozygous at all three loci were selected, and from these several different DLA-DRB1-DQA1-DQB1 haplotype combinations were identified. Dogs that were homozygous at only two loci were then selected. From these dogs many of the previous haplotypes were confirmed and also several further haplotypes were identified. The remaining dogs were examined using the haplotype data already identified and haplotypes were assigned to each of these dogs. From these dogs further possible haplotypes were identified.

TABLE 1
Distribution of dog breeds in the patient and control data sets

				FE
		IDDM	Controls	IDDM
	Breed	n = 460	n = 1047	n = 69

	Afghan Hound		2
	Australian Shepherd Dog	1	2
	Basset Hound		8
	Beagle	5	59	2
	Bernese Mountain Dog		7
	Bichon Frise	11	21	3
	Bloodhound		1
	Bouvier		2
	Boxer		51	1
	Briard		3
	Bull Mastiff		15	1
	Bulldog		3
	Chow Chow		6	1
	Collie (Bearded)	1	3	1
	Collie (Border)	26	41	11
	Collie (Rough)		5
	Corgi	4	3
	Dachshund (All types)	11	25	4
	Dalmatian	1	4
	Deerhound		1
	Doberman	5	36	1
	Elkhound	1
	Foxhound		2
	German Shepherd Dog		57	1
	Great Dane	1	6
	Greyhound		2
	Hovawart		6
	Husky	1	12	1
	Irish Wolfhound		5
	Japanese Akita		4
	Labrador	56	93	7
	Lhasa Apso	3	4
	Lurcher	1	4
	Mastiff		3
	Munsterlander (Large)		2
	Newfoundland	1	5
	Papillon		7
	Pharaoh Hound		1
	Pinscher (Miniature)	1
	Pointer		4
	Polish lowland sheepdog	2
	Pomeranian	2	2
	Poodle (All types)	8	25
	Pug		1
	Pyrenean Mountain Dog		4	1
	Retriever (Chesapeake Bay)	1
	Retriever (Floatcoat)		2
	Retriever (Golden)	6	44	1
	Rhodesian Ridgeback	1	18
	Rottweiler	4	19
	Samoyed	15	9	4
	Schnauzer (Miniature)	10	14
	Setter (English)	3	33
	Setter (Gordon)	3	3
	Setter (Irish)	1	9
	Sharpei		2
	Sheepdog (Old English)	3	8
	Sheepdog (Shetland)	4	3
	Shih Tzu	2	19
	Spaniel (CKCS)	19	17
	Spaniel (Clumber)		1
	Spaniel (Cocker)	15	30	2
	Spaniel (Field)		1
	Spaniel (Springer)	8	21	1
	Spinone (Italian)		2
	Spitz	1	2	1
	St Bernard		5
	Terrier (Airedale)		2
	Terrier (Border)	10	11
	Terrier (Boston)		1
	Terrier (Bull)	1	2
	Terrier (Cairn)	15	11	3
	Terrier (Dandie Dinmont)	1
	Terrier (Fox)	1	2
	Terrier (Jack Russell)	17	40	3
	Terrier (Maltese)		2
	Terrier (Manchester)		1
	Terrier (Patterdale)			1
	Terrier (Scottish)	1	3
	Terrier (Staffs Bull)	3	8
	Terrier (Tibetan)	7	6
	Terrier (Welsh)		1
	Terrier (West Highland	38	33	4
	White)
	Terrier (Yorkshire)	29	47	3
	Vizsla Hungarian		5
	Weimaraner	1	5
	Whippet	1	2
	X-Crossbreed	97	56	11

TABLE 2
Percentage of IDDM, control and female entire IDDM dogs with each haplotype

			IDDM		Controls		FE IDDM		Odds
DRB1	DQA1	DQB1	n = 460	%	n = 1047	%	n = 69	%	Ratio	P value

001	001	002	96	20.87	219	20.92	20	28.99
001	001	036	10	2.17	20	1.91		0.00
001	003	004	4	0.87	17	1.62		0.00
001	009	001	10	2.17	12	1.15	3	4.35
002	009	001	54	11.74	85	8.12	9	13.04	1.51	0.03
004	002	015	1	0.22	44	4.20		0.00
005	003	005	5	1.09	13	1.24		0.00
006	004	013	7	1.52	39	3.72	1	1.45
006	005	007	81	17.61	180	17.19	9	13.04
006	005	02001	8	1.74	24	2.29	1	1.45
008	003	004	10	2.17	21	2.01	1	1.45
009	001	008	55	11.96	65	6.21	4	5.80	2.05	0.0002
011	002	013	29	6.30	66	6.30	5	7.25
012	001	002	2	0.43	14	1.34	1	1.45
012	004	013	8	1.74	24	2.29	1	1.45
012	004	013017	37	8.04	105	10.03	5	7.25
013	001	002	40	8.70	70	6.69	7	10.14
015	006	003	7	1.52	27	2.58	2	2.90
015	006	019022	11	2.39	8	0.76	4	5.80
015	006	02002	25	5.43	37	3.53	3	4.35
015	006	022	13	2.83	14	1.34	7	10.14
015	006	023	158	34.35	268	25.60	15	21.74	1.52	0.0006
015	009	001	13	2.83	52	4.97	2	2.90
018	001	002	12	2.61	21	2.01	4	5.80
018	001	008	4	0.87	32	3.06	1	1.45
020	004	013	25	5.43	77	7.35	3	4.35
023	003	005	12	2.61	13	1.24	2	2.90
other	Rare	haplos	48	10.43	149	14.23	9	13.04
	Arg55		388	84.35	783	74.78	59	85.5	1.82	.00005
	004	013	76	16.52	242	23.11	9	13.04	0.66	0.005

TABLE 3
Percentage of dogs from selected breeds with a high risk and a protective haplotype

	DRB1*009
	haplotypes	DQA1*004/DQB1*013

Risk

IDDM

controls

IDDM

controls

IDDM

controls

Ratio

Breed

n

n

n

%

n

%

n

%

n

%

High	17.30	Samoyed	15	9	8	53.33	5	55.56	4	26.67	2	22.22
High	6.93	Terrier (Tibetan)	7	6	1	14.29	2	33.33
High	6.77	Terrier (Cairn)	15	11	5	33.33	3	27.27
moderate	3.60	Bichon Frise	11	21			3	14.29
moderate	3.48	Terrier	29	47							2	4.26
		(Yorkshire)
moderate	3.18	Schnauzer	10	14	7	70.00	13	92.86
		(Miniature)
moderate	2.89	Collie (Border)	26	41	3	11.54	3	7.32	2	7.69	3	7.32
moderate	2.83	Dachshund (all	11	25	7	63.64	4	16.00			2	8.00
		types)
moderate	2.51	Terrier (Border)	10	11							1	9.09
moderate	2.40	Poodle (All types)	8	25	1	12.50	1	4.00
small	1.74	Rottweiler	4	19
small	1.70	Terrier (WHWT)	38	33
small	1.48	Terrier (Jack	17	40	3	17.65	7	17.50			3	7.50
		Russell)
small	1.45	Spaniel (CKCS)	19	17	8	42.11	7	41.18	8	42.11	2	11.76
small	1.22	Doberman	5	36			1	2.78	5	100.00	36	100.00
Low	0.97	Labrador	56	93			3	3.23	25	44.64	58	62.37
Low	0.78	X-Crossbreed	97	56	13	13.40	5	8.93	18	18.56	11	19.64
Low	0.75	Spaniel (Cocker)	15	30							1	3.33
protected	0.42	Spaniel (English	8	21	1	12.50	3	14.29	2	25.00	12	57.14
		springer)
protected	1.19	Retriever	6	44					5	83.33	37	84.09
		(Golden)
protected	0.15	German		57							8	14.04
		Shepherd dog
protected	0.07	Boxer		51							3	5.88
		All IDDM no FE	460	1047	62	13.48	74	7.07	76	16.52	242	23.11

TABLE 4
Diabetes Susceptibility Alleles and Polymorphism which are typed

	DRB1*00201	98 C	126 A	254 G
	DRB1*00901	95 A	185 T
	DRB1*01501	11 G	62 C	126 A	161 G	173 G	218 G	236 G	254 A
	DRB1*01502	24 T	62 C	254 G
	DQB1*00101	10 A	93 C	152 G
	DQB1*008011	22 G	104 C	124 A	173 A	237 A
	DQB1*008012	104 T
	DQB1*00802	22 G	124 T	173 A
	DQB1*01301	22 T	172 C	237 A
	DQB1*02301	10 A	22 G	94 A	124 A	154 C	237 T
	DQA1*00101	12 A	58 A	148 G
	DQA1*00401	84 G	148 C	189 A	210 C
	dqa1*00402	84 T	189 A
	DQA1*00601	12 T	148 G	189 A	210 C
	DQA1*00901	12 T	58 T	148 G

DQB1	460	%	652	%	1124	%	c	d	d		X2	OR	Cl	p
001	77	16.74	110	16.87	168	14.95	383	542	956
002	152	33.04	227	34.82	352	31.32	308	425	772
003	7	1.52	15	2.30	27	2.40	453	637	1097
003v		0.00		0.00	23	2.05	460	652	1101
004	14	3.04	29	4.45	55	4.89	446	623	1069
005	18	3.91	21	3.22	26	2.31	442	631	1098
00502		0.00		0.00	1	0.09	460	652	1123
007	82	17.83	120	18.40	231	20.55	378	532	893
008	54	11.74	50	7.67	83	7.38	406	602	1041	x	4.8	1.29	1.06-1.57	0.03
00802	10	2.17	26	3.99	78	6.94	450	626	1046
011	5	1.09		0.00		0.00	455	652	1124
013	71	15.43	106	16.26	218	19.40	389	546	906	x	ns
013017	37	8.04	74	11.35	108	9.61	423	578	1016
015	2	0.43	6	0.92	46	4.09	458	646	1078	x	13.64	0.1	0.02-0.43	3E−04
017		0.00	1	0.15	3	0.27	460	651	1121
019	2	0.43	4	0.61	8	0.71	458	648	1116
019022	12	2.61	8	1.23	8	0.71	448	644	1116
02001	8	1.74	22	3.37	24	2.14	452	630	1100
02002	25	5.43	26	3.99	36	3.20	435	626	1088
022	13	2.83	12	1.84	14	1.25	447	640	1110
023	159	34.57	180	27.61	264	23.49	301	472	860	x	5.84	1.39	1.06-1.81	0.02
											19.9	1.72	1.35-2.20	1E−05
026	3	0.65	2	0.31	2	0.18	457	650	1122
028	3	0.65		0.00	1	0.09	457	652	1123
029		0.00		0.00	1	0.09	460	652	1123
030		0.00	1	0.15	1	0.09	460	651	1123
035	2	0.43	4	0.61	13	1.16	458	648	1111
036	10	2.17	16	2.45	16	1.42	450	636	1108
038		0.00	1	0.15	5	0.44	460	651	1119
041		0.00		0.00	1	0.09	460	652	1123
046	2	0.43	2	0.31	2	0.18	458	650	1122

						1124
	DQA1	460	%	652	%	cont	%	c	d	d
	001	214	46.52	300	46.01	493	43.86	246	352	631
	002	34	7.39	44	6.75	128	11.39	426	608	996
	003	31	6.74	50	7.67	87	7.74	429	602	1037
	004	77	16.74	135	20.71	241	21.44	383	517	883	x	4.21	0.74	0.55-0.99	0.04
	00402		0.00	2	0.31	4	0.36	460	650	1120
	005	90	19.57	133	20.40	247	21.98	370	519	877
	006	205	44.57	227	34.82	357	31.76	255	425	767	x	10.38	1.51	1.17-1.94	0.002
	007		0.00	1	0.15	1	0.09	460	651	1123
	008		0.00		0.00	1	0.09	460	652	1123
	009	76	16.52	113	17.33	170	15.12	384	539	954
	010	2	0.43	4	0.61	7	0.62	458	648	1117
	012011	1	0.22		0.00	1	0.09	459	652	1123
	012012	1	0.22	4	0.61	12	1.07	459	648	1112
	014	2	0.43		0.00	1	0.09	458	652	1123

DRB1	460	%	652	%	1124 cont	%	c	d	d
001	119	25.87	196	30.06	278	24.73	341	456	846
00103	1	0.22	1	0.15	1	0.09	459	651	1123
002	57	12.39	55	8.44	92	8.19	403	597	1032	x	4.23	1.54	1.02-2.31	0.04
											6.29	1.59	1.1-2.28	0.01
00203		0.00	4	0.61	4	0.36	460	648	1120
003	1	0.22	1	0.15	3	0.27	459	651	1121
004	1	0.22	6	0.92	44	3.91	459	646	1080
005	5	1.09	13	1.99	14	1.25	455	639	1110
006	96	20.87	146	22.39	288	25.62	364	506	836	x	ns
											ns
008	1	0.22	18	2.76	32	2.85	459	634	1092	x	8.93	0.08	0.00-0.54	0.003
00802	9	1.96	3	0.46	7	0.62	451	649	1117	x	4.34	4.32	1.07-20.19	0.04
009	61	13.26	62	9.51	89	7.92	399	590	1035	x	3.49	1.45	0.98-2.15	0.06	ns
											10.25	1.78	1.24-2.55	0.001
010	1	0.22		0.00		0.00	459	652	1124
011	29	6.30	26	3.99	66	5.87	431	626	1058
012	47	10.22	91	13.96	141	12.54	413	561	983
013	41	8.91	44	6.75	70	6.23	419	608	1054
		0.00		0.00	1	0.09	460	652	1123
015	219	47.61	255	39.11	385	34.25	241	397	739	x	7.62	1.41	1.10-1.81	0.006
											24.12	1.74	1.39-2.19	1E−06
01503		0.00	1	0.15	24	2.14	460	651	1100
016		0.00	3	0.46	6	0.53	460	649	1118
017	2	0.43	2	0.31	3	0.27	458	650	1121
018	16	3.48	34	5.21	61	5.43	444	618	1063
019	1	0.22	1	0.15	3	0.27	459	651	1121
020	25	5.43	44	6.75	77	6.85	435	608	1047
023	13	2.83	11	1.69	14	1.25	447	641	1110
024		0.00		0.00	4	0.36	460	652	1120
025	1	0.22	4	0.61	12	1.07	459	648	1112
028		0.00		0.00	1	0.09	460	652	1123
029		0.00	1	0.15	1	0.09	460	651	1123
03202		0.00		0.00	1	0.09	460	652	1123
033		0.00	1	0.15	5	0.44	460	651	1119
040	2	0.43	4	0.61	7	0.62	458	648	1117
046		0.00		0.00	6	0.53	460	652	1118
047		0.00	1	0.15	3	0.27	460	651	1121
048		0.00	3	0.46	4	0.36	460	649	1120
052	1	0.22		0.00	1	0.09	459	652	1123
053		0.00		0.00	1	0.09	460	652	1123
054		0.00	1	0.15	1	0.09	460	651	1123
069		0.00		0.00	16	1.42	460	652	1108
071		0.00	3	0.46	3	0.27	460	649	1121
073	1	0.22	4	0.61	5	0.44	459	648	1119
075		0.00	2	0.31	2	0.18	460	650	1122
a79		0.00		0.00	1	0.09	460	652	1123
a79v		0.00		0.00	1	0.09	460	652	1123
Ik3389	2	0.43	2	0.31	2	0.18	458	650	1122
New	3	0.65	6	0.92	11	0.98	457	646	1113
Ik3385	1	0.22		0.00		0.00	459	652	1124
n3315	1	0.22		0.00		0.00	459	652	1124

			460 diab		652		1124
DRB1	DQA1	DQB1	no Fe	%	matcon	%	cont	%	c	d	d
	001	002	160	34.63	244	37.42	372	33.10	300	408	752
	001	008	64	13.85	76	11.66	155	13.79	396	576	969	xx	ns
001	001	036	10	2.16	16	2.45	16	1.42	450	636	1108
	002	013	33	7.14	37	5.67	80	7.12	427	615	1044
	002	015	2	0.43	6	0.92	46	4.09	458	646	1078	xx	13.64	0.1	0.02-0.43	0.0002
	003	004	14	3.03	29	4.45	56	4.98	446	623	1068
	003	005	18	3.90	24	3.68	30	2.67	442	628	1094
	004	013	40	8.66	70	10.74	143	12.72	420	582	981	xx	4.79	0.65	0.44-0.96	0.03
012	004	013017	38	8.23	75	11.50	109	9.70	422	577	1015
006	005	007	82	17.75	121	18.56	232	20.64	378	531	892
006	005	02001	8	1.73	22	3.37	24	2.14	452	630	1100
006	005	028	3	0.65			1	0.09	457	652	1123
015	006	003	7	1.52	15	2.30	27	2.40	453	637	1097
01503	006	003v					23	2.05	460	652	1101
015	006	011	5	1.08				0.00	455	652	1124
015	006	019022	12	2.60	8	1.23	8	0.71	448	644	1116
015	006	02002	25	5.41	26	3.99	36	3.20	435	626	1088
015	006	022	13	2.81	12	1.84	14	1.25	447	640	1110
	006	023	158	34.20	177	27.15	260	23.13	302	475	864	x	6.31	1.4	1.08-1.83	0.01
													20.57	1.74	1.36-2.22	0.000006
	009	001	77	16.67	112	17.18	171	15.21	383	540	953
040	010	019	2	0.43	4	0.61	7	0.62	458	648	1117
025	012012	035	1	0.22	4	0.61	12	1.07	459	648	1112
Other			13	2.81	16	2.45	34	3.02	447	636	1090
rare
haplos

Allelic names and sequences for class II alleles are shown below:

DLA dqa1.L12, exon 2 (nucleotides 15-260)

>DQA1*00101

GAC CAT GTT GCC AAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TAC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT AGA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA ATA AAA CAA AAC TTG AAC ATC ATG ACT

AAA AGG TCC AAC CAA ACT GCT GCT ACC AAT

>DQA1*00201

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TAC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT ACA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA ACA AAA CAA AAC TTG AAC ATC ATG ACT

AAA AGG TCC AAC AAA ACT GCT GCT ACC AAT

>DQA1*00301

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TAC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT ACA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCC AGA GCA AAA CAA AAC TTG AAC ATC CTG ACT

AAA AGT TCC AAC CAA ACT GCT GCT ACC AAT

>DQA1*00401

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TAC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT ACA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA ATA AAA CAA AAC TTG AAC ATC CTG ACT

AAA AGG TCC AAC CAA ACT GCT GCT ACC AAT

>DQA1*005011

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TTC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT ACA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA ACA AAA CAA AAC TTG AAC ATC ATG ACT

AAA AGG TCC AAC AAA ACT GCT GCT ACC AAT

>DQA1*005012

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TTC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT ACA AGT TTT GAC CCA CAG GGT GCG CTG AGA AAC

TTG GCT ATA ACA AAA CAA AAC TTG AAC ATC ATG ACT

AAA AGG TCC AAC AAA ACT GCT GCT ACC AAT

>DQA1*00601

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TAC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT AGA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA ATA AAA CAA AAC TTG AAC ATC CTG ACT

AAA AGG TCC AAC CAA ACT GCT GCT ACC AAT

>DQA1*00701

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TAC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT ACA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA ACA AAA CAA AAC TTG AAC ATC ATG ACT

AAA AGG TCC AAC CAA ACT GCT GCT ACC AAT

>DQA1*00801

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TAC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT ACA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCC AGA GCA AAA CAA AAC TTG AAC ATC CTG ACT

AAA AGG TCC AAC CAA ACT GCT GCT ACC AAT

>DQA1*00901

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TTC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT AGA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA ATA AAA CAA AAC TTG AAC ATC ATG ACT

AAA AGG TCC AAC CAA ACT GCT GCT ACC AAT

>DQA1*01001

GACCATGTTGCCTACTACGGCATAAATGTCTACCAGTCTTACGGTCCCTC

TGGCCAGTACACCCATGAATTTGATGGCGATGAGGAGTTCTACGTGGACC

TGGAGAAGAAGGAAACTGTCTGGCGGCTGCCTGTGTTTAGCACATTTAGA

AGTTTTGACCCACAGGGTGCACTGAGAAACTTGGCTATAGCAAAACAAAA

CTTGAACATCCTGACTAAAAGTTCCAACCAAACTGCTGCTACCAAT

>DQA1*01101

GACCATGTTGCCTACTACGGCATAAATGTCTACCAGTCTTACGGTCCCTC

TGGCCAGTACACCCATGAATTTGATGGCGATGAGGAGTTCTACGTGGACC

TGGAGAAGAAGGAAACTGTCTGGCGGCTGCCTGTGTTTAGCACATTTACA

AGTTTTGACCCACAGGGTGCACTGAGAAACTTGGCTATAATAAAACAAAA

CTTGAACATCATGACTAAAAGGTCCAACAAAACTGCTGCTACCAAT

>DQA1*012011

GACCATGTTGCCTACTACGGCATAAATGTCTACCAGTCTTACGGTCCCTC

TGGCCAGTACACCCATGAATTTGATGGCGATGAGGAGTTCTACGTGGACC

TGGAGAAGAAGGAAACTGTCTGGCGGCTGCCTGTGTTTAGCACATTTGCA

AGTTTTGACCCACAGGGTGCACTGAGAAACTTGGCTATAGCAAAACAAAA

CTTGAACATCATGACTAAAAGGTCCAACCAAACTGCTGCTACCAAT

>dqa1*012012

GACCATGTTGCCTACTACGGCATAAATGTCTACCAGTCTTACGGTCCCTC

TGGCCAGTACACCCATGAATTTGATGGCGATGAGGAaTTCTACGTGGACC

TGGAGAAGAAGGAAACTGTCTGGCGGCTGCCTGTGTTTAGCACATTTGCA

AGTTTTGACCCACAGGGTGCACTGAGAAACTTGGCTATAGCAAAACAAAA

CTTGAACATCATGACTAAAAGGTCCAACCAAACTGCTGCTACCAAT

>DQA1*01301

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TAC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT AGA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA ACA AAA CAA AAC TTG AAC ATC ATG ACT

AAA AGG TCC AAC AAA ACT GCT GCT ACC AAT

>DQA1*014011

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TAC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT AGA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA ATA AAA CAA AAC TTG AAC ATC ATG ACT

AAA AGG TCC AAC CAA ACT GCT GCT ACC AAT

>DQA1*014012

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TAC ACA CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT AGA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA ATA AAA CAA AAC TTG AAC ATC ATG ACT

AAA AGG TCC AAC CAA ACT GCT GCT ACC AAT

>DQA1*01501

GACCATGTTGCCAACTACGGCATAAATGTCTACCAGTCTTACGGTCCCTC

TGGCCAGTTCACCCATGAATTTGATGGCGATGAGGAGTTCTACGTGGACC

TGGAGAAGAAGGAAACTGTCTGGCGGCTGCCTGTGTTTAGCACATTTAGA

AGTTTTGACCCACAGGGTGCACTGAGAAACTTGGCTATAATAAAACAAAA

CTTGAACATCATGACTAAAAGGTCCAACCAAACTGCTGCTACCAAT

>07v1

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TTC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT ACA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA ACA AAA CAA AAC TTG AAC ATC ATG ACT

AAA AGG TCC AAC CAA ACT GCT GCT ACC AAT

>dqa1*00402

GACCATGTTGCCTACTACGGCATAAATGTCTACCAGTCTTACGGTCCCTC

TGGCCAGTACACCCATGAATTTGATGGCGATGAGttGTTCTACGTGGACC

TGGAGAAGAAGGAAACTGTCTGGCGGCTGCCTGTGTTTAGCACATTTACA

AGTTTTGACCCACAGGGTGCACTGAGAAACTTGGCTATAATAAAACAAAA

CTTGAACATCCTGACTAAAAGGTCCAACCAAACTGCTGCTACCAAT

>dqa383-11

GACCATGTTGCCAACTACGGCATAAATGTCTACCAGTCTTACGGTCCCTC

TGGCCAGTACACCCATGAATTTGATGGCGATGAGGAGTTCTACGTGGACC

TGGAGAAGAAGGAAACTGTCTGGCGGCTGCCTGTGTTTAGCACATTTACA

AGTTTTGACCCACAGGGTGCACTGAGAAACTTGGCCATAACAAAACAAAA

CTTGAACATCATGACTAAAAGGTCCAACAAAACTGCTGCTACCAAT

>DQA1*01601

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TAC ACA CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT ACA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA ATA AAA CAA AAC TTG AAC ATC ATG ACT

AAA AGG TCC AAC CAA ACT GCT GCT ACC AAT

>DQA1*01602

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TAC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAT ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT ACA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA ATA AAA CAA AAC TTG AAC ATC ATG ACT

AAA AGG TCC AAC CAA ACT GCT GCT ACC AAT

>DQA/M/LO51

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TAC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT ACA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA GCA AAA CAA AAC TTG AAC ATC CTG ACT

AAA AGT TCC AAC CAA ACT GCT GCT ACC AAT

>DQA/W53/B

GAC CAT GTT GCC aAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TaC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT ACA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA AtA AAA CAA AAC TTG AAC ATC ATG ACT

AAA AGG TCC AAC cAA ACT GCT GCT ACC AAT

>DQA1*01701

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TAC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT GCA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT AGA GCA AAA CAA AAC TTG AAC ATC CTG ACT

AAA AGT TCC AAC CAA ACT GCT GCT ACC AAT

>DQA/COY954A

GAC CAT GTT GCC TAC TAC GGC ATA AAT GTC TAC CAG

TCT TAC GGT CCC TCT GGC CAG TTC ACC CAT GAA TTT

GAT GGC GAT GAG GAG TTC TAC GTG GAC CTG GAG AAG

AAG GAA ACT GTC TGG CGG CTG CCT GTG TTT AGC ACA

TTT ACA AGT TTT GAC CCA CAG GGT GCA CTG AGA AAC

TTG GCT ATA ATA AAA CAA AAC TTG AAC ATC ATG ACT

AAA AGG TCC AAC CAA ACT GCT GCT ACC AAT

>hcdqa-1DM

GACCATGTTGCCTACTACGGCATAAATGTCTACCAGTCTTACGGTCCCTC

TGGCCAGTACACCCATGAATTTGATGGCGATGAGGAGTTCTACGTGGACC

TGGAGAAGAAGGAAACTGTCTGGCGGCTGCCTGTGTTTAGCACATTTACA

AGTTTTGACCCACAGGGTGCACTGAGAAACTTGGCTATAgCAAAACAAAA

CTTGAACATCATGACTAAAAGGTCCAACAAAACTGCTGCTACCAAT

>awddqa01

GACCATGTTGCCAACTACGGCATAAATGTCTACCAGTCTTACGGTCCCTC

TGGCCAGTTCACCCATGAATTTGATGGCGATGAGGAGTTCTATGTGGACC

TGGAGAAGAAGGAAACTGTCTGGCGGCTGCCTGTGTTTAGCACATTTAGA

AGTTTTGACCCACAGGGTGCACTGAGAAACTTGGCTATAATAAAACAAAA

CTTGAACATCCTGACTAAAAGGTCCAaCCAAAcTGCtGCTaCCAaT

>dqa-1k-ew73

GACCATGTTGCCTACTACGGCATAAATGTCTACCAGTCTTACGGTCCCTC

TGGCCAGTACACCCATGAATTTGATGGCGATGAGttGTTCTACGTGGACC

TGGAGAAGAAGGAAACTGTCTGGCGGCTGCCTGTGTTTAGCACATTTACA

AGTTTTGACCCACAGGGTGCACTGAGAAACTTGGCTATAgcAAAACAAAA

CTTGAACATCCTGACTAAAAGGTCCAACCAAACTGCTGCTACCAAT

DLA-DQB1 (base 1 = base 16 of exon 2)

>DQB1*00101

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCGGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCGGAGGCG

GGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*00202

GATTTCGTGTTCCAGTATAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCGACAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*00301

GATTTCGTGTACCAGTTTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTCGGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*00401

GATTTCGTGTTCCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB1*00501

GATTTCGTGTTCCAGTATAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*00502

GATTTCGTGTTCCAGTATAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTACGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*00701

GATTTCGTGTACCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGCGAGAGACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCGGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAGGCG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB1*008011

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCGACAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*008012

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTTGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCGACAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*00802

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCGACAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*01101

GATTTCGTGTACCAGTTTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTCGGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*01201

GATTTCGTGTTCCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGCGAGAGACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCGGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAGGCG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB1*01301

GATTTCGTGTACCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*01302

GATTTCGTGTACCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*01303

GATTTCGTGTACCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB1*01304

GATTTCGTGTACCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB1*01401

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGCGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCGGAAGCG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB1*01501

GATTTCGTGTACCAGTGTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGTTTCTGGCTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCTCGGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCAGGAGCG

GGCAACGGTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB1*01601

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAAGCATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGTCGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCGGAAGCG

GGCCGAGGTGGACAGGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*01701

GATTTCGTGTTCCAGTGTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGTTTCTGGCTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTCCTGGAACGGGCAGAAGGAGTTCTTGGAGCAGGAGCG

GGCAACGGTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB1*01801

GATTTCGTGTACCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTGCG

GGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

CCACGTTGCAGCGGCGA

>DQB1*01901

GATTTCGTGTTCCAGTGTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGTTTCTGGCTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCTCGGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAAGAGCG

GGCAACGGTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*02001

GATTTCGTGTACCAGTTTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAAGCATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGTCGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCGGAAGCG

GGCCGCGGTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*02002

GATTTCGTGTACCAGTTTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAAGCATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGTCGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCGGAAGCG

GGCCGCGGTGGACAGGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*02101

GATTTCGTGTACCAGTTTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAAGCATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGTCGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCGGAAGCG

GGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*02201

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTCGGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*02301

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTCGGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGcAGACACAACTACGGGTTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*02302

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTCGGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGcAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB1*02401

GATTTCGTGTACCAGTGTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGTTTCTGGCTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGGAGCG

GGCAACGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>jmadqb-ccah005

GATTTCGTGTTCCAGTGTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*02601

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAAGCATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGTCGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCGGAAGCG

GGCCGCGGTGGACAGGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*02701

GATTTCGTGTACCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGCGAGAGACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB1*02801

GATTTCGTGTACCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGCGAGAGACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCGGACGCTGAGTACTGGAACCGGCAGAAGGAGCTCTTGGAGCAGAGGCG

GGCCGCGGTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB1*02901

GATTTCGTGTACCAGTGTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGTTTCTGGCTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGGAGCG

GGCAACGGTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB1*03001

GATTTCGTGTTCCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCGGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCGGAGGCG

GGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*03101

GATTTCGTGTTCCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTCGGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*03201

GATTTCGTGTTCCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCGACAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*03301

GATTTCGTGTACCAGTTTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAAGCATCTATAACCGGGAGGAGTTGGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGTCGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCGGAAGCG

GGCCGCGGTGGACAGGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*03401

GATTTCGTGTTCCAGTTTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCGGAGGCG

GGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*03501

GATTTCGTGTACCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGCGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAGGCG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACAAGGTTGGAAGAGCTC

TACACGTTGCAGCGGcGA

>DQB1*03601

GATTTCGTGTTCCAGTATAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>dqb1*03701

GATTTCGTGTTCCAGTATAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACGGGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>1kdqbE18

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCGGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCGGAGGCG

GGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*03901

GATTTCGTGTTCCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGCTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>dqbC3007new

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTGGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCGACAGAAGGACGAGATGGACCGGGCACG

GGCCGCGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>dqbrw269new

GATTTCGTGTACCAGTGTAAGTGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGCTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTTGGCTGAGTACTGGAACCCGCAGAAGGACAACATGGAGCAGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>dqbw30new

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAAACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCGGAAGCG

GGCCGAGCTGGACAcGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*03801

GATTTCGTGTTCCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*04001

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGCGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTaCCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCGGAAGCG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>dqb383-9

GATTTCGTGTtCCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGcGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTaCCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCGGAAGCG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>dqb-a32-008v

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTtCCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCcgCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>dqbwAnew

GATTTCGTGTACCAGTGTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAGGCATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCGGAAGCG

GGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*04101

GATTTCGTGTTCCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB1*04201

GATTTCGTGTTCCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGCTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCAGACGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>dqb381-9

GATTTCGTGTTCCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGgCTAgATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGtACCGGGCGGTCACGGAGCTCGGGCGG

CCCtACGCTGAGTACTGGAACCGACAGAAGGACaAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*04301

GATTTCGTGTaCCAGTTTAAGGgCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGgCtAaAtACATCTATAACCGGGAGGAGttCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACGGGCAGAAGGAGaTCTTGGAGCGGAAGCG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGgtGGAAGAGCTCt

aCACGTTGCAGCGGCGA

>DQB/AA

GATTTCGTGTTCCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACCCGCAGAAGGACAACATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB/BB

GATTTCGTGTTCCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACCCGCAGAAGGACAAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB/DD

GATTTCGTGTTCCAGTTTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTACGCTGAGTACTGGAACCCGCAGAAGGAGTTCTTGGAGCGGGCGCG

GGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*04401

GATTTCGTGTTCCAGTTTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACGGGCAGAAGGAGTTCTTGGAGCGGGCGCG

GGCCGCGGTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB/H

GATTTCGTGTTCCAGTTTAAGGCCCAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACGGGCAGAAGGAGTTCTTGGAGCGGGCGCG

GGCCGCGGTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB/I

GATTTCGTGTTCCAGTTTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTACGCTGAGTACTGGAACGGGCAGAAGGAGTTCTTGGAGCGGGCGCG

GGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB/J

GATTTCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGCGAGAGACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCGGAAGCG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*04501

GATTTCGTGTtCCAGTTTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGaCGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTaCGCTGAGTACTGGAACGGGCAGAAGGAGtTCTTGGAGCGGgCGCG

GGCcGCGgTGGAcAcGGTGTGcAGACAcAACTACGGGGTGGAAGAGCTCa

cCACGTTGCAGCGGCGA

>DQB/R

gATTTcGTGTACCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACccGCAGAAGGAcCagaTGGACCgGgtaCG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACgGGgTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB/S

GATTTCGTGTtCCAGTGTAAGGgCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGcTTCTGaCTAAATACATCTATAACCGGGAGGAGTaCGTGC

GCTTCGACAGCGACGTGGGGGAGTaCCGGGCGGTCACGGAGCTCGGGCGG

CCCtggGCTGAGTACTGGAACcCGCAGAAGGAcCagaTGGAcCgGGtaCG

GGCcgaGcTGGACACGGTGTGCAGACAcAACTACGGGtTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>DQB/U

GATTtCGTGTACCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGCGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCgACGCTGAGTACTGGAACGGGCAGAAGGAGTTCTTGGAGCGGGCGCG

GGCCGCGGTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB/CVA307/B

GATTTCGTGTwCCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTGGGCTGAGTACTGGAACCCGCAgAAGgACGAGATGGACcGGGTACg

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGgTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>dqbIW001

GATTTCGTGTTCCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>dqb1*03602

GATTTCGTGTTCCAGTATAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>dqb1*03603

GATTTCGTGTTCCAGTATAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>dqb1*00202

GATTTCGTGTTCCAGTATAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCGACAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>dqb1*04601

GATTTCGTGTACCAGTTTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCGACAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>DQB1*04701

GATTTCGTGTTCCAGTGTAAGTTCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGTTTCTGGCTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCAGGAGCG

GGCAACGGTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>lkawd14

gATTtCGTgTaCcAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAACACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCGGCAGAAGGACGAGGTGGACCGGGTACG

GGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGATGGAGGAGCTCA

CCACGTTGCAGCGGCGA

>lk-awd16

gATTtCgTGTaCcAGTTTAaGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGTTCGTGGACAGATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTACTGGAACCGGCAGAAGGACGAGGTGGACCGGGTACG

GGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGATGGAGGAGCTCA

CCACGTTGCAgCGGCGA

>dqb013 + 017

GATTTCGTGTWCCAGTkTAAGkyCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGyTTCTGrCTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCGACGCTGAGTmCTGGAACsSGCAGAAGGASkWSWTGGASCrGGWrCG

GGCmrmGSTGGACACGGTGTGCAGACACAACTACGGGGTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>dqb019 + 022

GATTTCGTGTwCCAGTkTAAGGsCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGyTTCTGrCTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTWCCGGGCGGTCACGGAGCTCGGGCGG

CCCTCGGCTGAGTACTGGAACSSGCAGAAGGASSWSWTGGASCrrGWrCG

GGCmrmGSTGGACACGGTGTGCAGACACAACTACGGGWkGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>dqb8061new

GATTTCGTGTACCAGTGTAAGGCCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGCGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGCGG

CCCTCGGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAGGCG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGAGGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>dqb8062new

GATTTCGTGTACCAGTGTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGGCGAGAGACATCTATAACCGGGAGGAGCACGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCTACGCTGAGTACTGGACGGGCAGAAGGAAGCTCTTGGAGCGGAAGCG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

>dqb-1k-ewC

GATTTCGTGTTCCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTTCGTGC

GCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGCGG

CCCgaCGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCT

ACACGTTGCAGCGGCGA

>dqb-1k-ew88

GATTTCGTGTtCCAGTTTAAGGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTACGTGC

GCTTCGACAGCGACGTGGGGGAGTtCCGGGCGGTCACGGAGCTCGGGCGG

CCCgaCGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCt

aCACGTTGCAGCGGCGA

>dqb-1k-023v

GATTTCGTGTACCAGTTTAASGGCGAGTGCTATTTCACCAACGGGACGGA

GCGGGTGCGGCTTCTGACTAAATACATCTATAACCGGGAGGAGTACGTGC

GCTTCGACAGCGACGTGGGGGAGTtCCGGGCGGTCACGGAGCTCGGGCGG

CCCTCGGCTGAGTACTGGAACCCGCAGAAGGACGAGATGGACCGGGTACG

GGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGTTGGAAGAGCTCA

CCACGTTGCAGCGGCGA

DLA-DRB

>DRB1*00101

CACATTTCTTGGAGGTGGCAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGTCGCTGAGTCCTGGAACGGGCAGAAGGAGATCTTGGAGCAGGAG

CGGGCAACGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*00102

CACATTTCTTGGAGGTGGCAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGTCGCTGAGTCCTGGAACGGGCAGAAGGAGATCTTGGAGCAGGAG

CGGGCAACGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*00201

CACATTTCTTGGAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGGCGAGAGACATCTATAACCGGGAGGAGATCCT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCATCGCTGAGTCCTGGAACCGGCAGAAGGAGATCTTGGAGCAGAGG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCGCGGTGCAGCGGCGAG

>DRB1*00202

CACATTTCTTGGAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGGCGAGAGACATCTATAACCGGGAGGAGATCCT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCATCGCTGAGTCCTGGAACCGGCAGAAGGAGATCTTGGAGCAGAGG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*00301

CACATTTCTTGGAGGTGGCAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*00401

CACATTTCGTGTACCAGTTTAAGCCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGACACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCAGGAG

CGGGCAACGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*00501

CACATTTCTTGGAGATGTTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGGAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*00601

CACATTTCTTGGAGGTGGCAAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCTATAACCGGGAGGAGTACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACCCGCAGAAGGAGCTCTTGGAGCGGGCG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*00701

CACATTTCTTGGAGGTGGCAAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACCCGCAGAAGGAGCTCTTGGAGGGGGGC

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*00801

CACATTTCGTGAAGATGTATAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGATGAGAGACATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCGGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*00802

CACATTTCGTGAAGATGTATAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGATGAGAGACATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCGGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCGCGGTGCAGCGGCGAG

>DRB1*00901

CACATTTCTTGGAGGTGGCAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGTTCTTGGAGCGGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*010011

CACATTTCGTGTACCAGTTTAAGCCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGTCGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCAGGAG

CGGGCAACGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCaCGGTGCAGCGGCGAG

>DRB1*010012

CACATTTCGTGTACCAGTTTAAGCCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCACAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGTCGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCAGGAG

CGGGCAACGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCRCGGTGCAGCGGCGAG

>DRB1*01101

CACATTTCGTGAAGATGTTTAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGCGAGAAGCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*01201

CACATTTCGTGAGGATGTATAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTTCTGGCGAGAAGCATCTATAACCGGGAGGAGTTCGC

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAGG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*01301

CACATTTCGTGTACCAGTTTAAGCCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGGAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*01302

CACATTTCGTGTACCAGTTTAAGCCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGGAG

CGGGCCGCGGTGGACACGGTGTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*01401

CACATTTCTTGGAGATGTTAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACCCGCAGAAGGAGCTCTTGGAGCGGGCG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*01501

CACATTTCTTGGAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGTGAGAGACATCTATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*01502

CACATTTCTTGGAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGTGAGAGACATCTATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCGCGGTGCAGCGGCGAG

>DRB1*01503

CACATTTCTTGGAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGTGAGAGACATCTATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*01504

CACATTTCTTGGAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGTGAGAGACATCTATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*01601

CACATTTCTTGGAGGTGGCAAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*01701

CACATTTCGTGAAGATGTTTAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTTCTGGCGAGAAGCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGGCG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*01702

CACATTTCGTGAAGATGTTTAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTTCTGGCGAGAAGCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGGCG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*01801

CACATTTCTTGGAGGTGGCAAAGTCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*01901

CACATTTCGTGAGGATGTATAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTTCTGGCGAGAAGCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAGG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*02001

CACATTTCTTGAAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTGGTGGAAAGAGACATCTATAACCGGGAGGAGTACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCTCGGCTGAGTCCTGGAACCGGCAGAAGGAGTTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*02101

CACATTTCGTGAAGATGTTTAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGCGAGAAGCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGCCCGCGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*02201

CACATTTCGTGTACCAGTTTAAGCCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACGGGCAGAAGGAGATCTTGGAGCAGGAG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*02301

CACATTTCTTGGAGATGTTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGGAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*02401

CACATTTCTTGGAGGTGTTAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*02501

CACATTTCTTGGAGGTGTTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTGGTGGAAAGATACATCTATAACCGGGAGGAGTTCGC

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*02601

CACATTTCTTGGAGATGTTAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*02701

CACATTTCGTGTACCAGTTTAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACGGGCAGAAGGAGATCTTGGAGCAGGAG

CGGGCAACGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*02801

CACATTTCTTGGAGGTGGCAAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACCCGCAGAAGGAGCTCTTGGAGCGGGCG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*02901

CACATTTCGTGAAGATGTATAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGATGAGAGACATCTATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACGGGCAGAAGGAGATCTTGGAGCGGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCGCGGTGCAGCGGCGAG

>DRB1*03001

CACATTTCTTGGAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGTGAGAGACATCTATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCRCGGTGCAGCGGCGAG

>DRB1*03101

CACATTTCTTGAAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGATGAGAGACATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCGCGGTGCAGCGGCGAG

>DRB1*03201

CACATTTCGTGTACCAGTTTAAGCCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGTCGCTGAGTCCTGGAACGGGCAGAAGGAGATCTTGGAGCAGGAG

CGGGCAACGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*03202

CACATTTCGTGTACCAGTTTAAGCCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGTCGCTGAGTCCTGGAACGGGCAGAAGGAGATCTTGGAGCAGGAG

CGGGCAACGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*03301

CACATTTCTTGGAGATGTTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGGTGAGAGACATCTATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAGG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*03501

CACATTTCGTGAAGATGTTTAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGCGAGAAGCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACCGGCAGAAGGAGTTCTTGGAGCAGAGG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTCACGGTGCAGCGGCGAG

>DRB1*03601

CACATTTCTTGGAGATGTTAAAGTCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*03701

CACATTTCTTGgAGgTGGcAAAGgcCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTtcgTGgaaAGAtACATCTATAACCGGGAGGAGTaCGT

GCGCTTCGACAGCGACGTGGGGGAGTaCCGGGCGGTCACGGAGCTCGGGC

GGCcCGACGCTGAGTCCTGGAACccGCAGAAGGAGCTCTTGGAGCgGgcG

CGGGCCGCGGTGGACACCTACTGCAGAcAcAACTACGGGGTGggcGAGAG

CTTCaCGGTGCAGCGGCGAG

>DRB1*03801

CACATTTCTTGGAGATGgTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCtTCTGgTGAGAGACATCTATAACCGGGAGGAGcACGT

GCGCTTCGACAGCGACGTGGGGGAGTaCCGGGCGGTCACGGAGCTCGGGC

GGCcCGACGCTGAGTaCTGGAACGGGCAGAAGGAGCTCTTGGAGCgGAgG

CGGGCCGaGGTGGACACggtgTGCAGACACAACTACcGGGTGATTGAGAG

cTTCaCGGTGCAGCGGCGAG

>DRB1*04001

CACATTTCTTGAAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTGGTGGAAAGAGACATCTATAACCGGGAGGAGTACGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCTCGGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCAGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCGCGGTGCAGCGGCGAG

>DRB1*04101

CACATTTCTTGGAGATGTTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGATGAGAGACATCTATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCGCGGTGCAGCGGCGAG

>DRB1*04201

CACATTTCTTGGAGATGTTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGGTGAGAGACATCTATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCGCGGTGCAGCGGCGAG

>DRB1*04301

CACATTTCTTGgAgAtGTTAAAGTTCGAGTGCCaTTTcACCAACGGGACG

GAGCGGGTGCGGTATCTGGTGAGAGACATCTATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACCGGGTGGGCGAgAG

CTTCACGGTGCAGCGGCGAG

>DRB1*04401

CACATTTCTTGgAGgTGGcAAAGTcCGAGTGCtATTTCACCAACGGGACG

GAGCGGGTGCGGTtagTGgaaAGAtACATCCATAACCGGGAGGAGaaCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCcCGACGCTGAGTCCTGGAACcGGCAGAAGGAGCTCTTGGAGCAGAgG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACcGGGTGggcGAGAG

CTTCaCGGTGCAGCGGCGAG

>DRB1*04501

CACATTTCTTGGAGATGTTAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*04502

CACATTTCTTGGAGATGTTAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*04601

CACATTTCTTGGAGATGTTAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGGAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*04701

CACATTTCTTGAAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGATGAGAGACATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCGGAGG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*04801

CACATTTCTTGGAGATGtTAAAGTcCGAGTGCtATTTCACCAACGGGACG

GAGCGGGTGCGGTtcgTGgaaAGAtACATCCATAACCGGGAGGAGAaCgT

GCGCTTCGACAGCGACGTGGGGGAGTaCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCgGAAG

CGGGCCGaGGTGGACACCTACTGCAGACACAACTACgGGGTGattGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*04901

CACATTTCTTGAAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTGGTGGAAAGAGACATCTATAACCGGGAGGAGTACGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCTCGGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCGCGGTGCAGCGGCGAG

>DRB1*05001

CACATTTCTTGGAGATGGTAAAGTCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGTGAGAGACATCTATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCGCGGTGCAGCGGCGAG

>DRB1*05101

CACATTTCGTGTACCAGTTTAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACGGGCAGAAGGAGATCTTGGAGCAGGAG

CGGGCAACGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*05201

CACATTTCTTGGAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGCTGAGAGACATCTATAACCGGGAGGAGATCCT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*05301

CACATTTCTTGAAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGATGAGAGACATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCAGGAG

CGGGCAACGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*05401

CACATTTCTTGGAGGTGGCAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*05501

CACATTTCTTGGAGATGTATAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTTCTGGCGAGAAGCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCATCGCTGAGTCCTGGAACCGGCAGAAGGAGTTCTTGGAGCGGAGG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*05601

CACATTTCTTGGAGGTGGCAAGGCCGAGTGCTATTTCACCAACGGGACGG

AGCGGGTGCGGTTCGTGGAAAAGATACATCCATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*05701

CACATTTCGTGTACCAGTTTAAGCCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCAGGAG

CGGGCAACGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*05801

CACATTTCGTGTACCAGTTTAAGCCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGATCCT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGTCGCTGAGTCCTGGAACGGGCAGAAGGAGATCTTGGAGCAGGAG

CGGGCAACGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

>drb1*05901

CACATTTCGTGAAGATGTTTAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGCGAGAAGCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>drb1*06101

CACATTTCGTGTACCAGTTTAAGCCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCTCGGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCGCGGTGCAGCGGCGAG

>drb1*06201

CACATTTCTTGGAGATGTTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGATGAGAGACATCTATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*06301

CACATTTCTTGGAGATGTTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGATGAGAGACATCTATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*06401

CACATTTCTTGGAGATGTTTAAGTTCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGTGAGAAGCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCATCGCTGAGTCCTGGAACCGGCAGAAGGAGTTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*06501

CACATTTCGTGAGGATGTTTAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTTCTGGCGAGAAGCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACCGGCAGAAGGAGCTCTTGGAGCAGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*06601

CACATTTCTTGGAGATGTTAAAGTCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGTGAGAGACATCTATAACCGGGAGGAGTTGGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCATCGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>DRB1*06701

CACATTTCTTGGAGATGTTAAAGtcCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGGTGAGAGACATCTATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAGG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>jmadrb-ccah002

CACATTTCTTGGAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGTGAGAGACATCTATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTAAGTACTACAACGGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACGGTGTGCAAACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>jmadrb-d002

CACATTTCTTGGAGATGTTAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCGCGGTGCAGCGGCGAG

>jmadrb-d004

CACATTTCGTGAAGATGTTTAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGCGAGAAGCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>jmadrb-vg1002

CACATTTCTTGGAGATGTTAAGTCCGAGTGCTATTTCACCAACGGGACGG

AGCGGGTGCGGTTCGTGGAAAAGATACATCCATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCAGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCGCGGTGCAGCGGCGAG

>jsdrb-coy1057a

CACATTTCTTGGAGATGTTAAAGtTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGATGAGAGACATCTATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCGGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>jsdrb-efin8der

CACATTTCGTGTACCTGTTTAAGCCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACGGGCAGAAGGAGATCTTGGAGCAGGAG

CGGGCAACGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>jsdrb-hlat17der

CACATTTCTTGAAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTGGTGGAAAGAGACATCTATAACCGGGAGGAGTACGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCTCGGCTGAGTCCTGGAACCGGCAGAAGGAGTTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACGGTgTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>jsdrb-oest4der

CACATTTCTTGGAGATGTTAAAGTCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>jsdrb-ploo1der

CACATTTCTTGaAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTGGTGGAAAGAGACATCTATAACCGGGAGGAGTACGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCTCGGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>jsdrb-qfinl1der

CACATTTCGTGTACCTGTTTAAGCCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGTCGCTGAGTCCTGGAACGGGCAGAAGGAGATCTTGGAGCAGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>jsdrb-rest6der

CACATTTCTTGGAGGTGGCAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGAACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>lk03102

CACATTTCTTGAAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGATGAGAGACATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCaCGGTGCAGCGGCGAG

>lk035v-mw-u

CACATTTCGTGAAGATGTTTAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGCGAGAAGCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGTTCTTGGAGCAGAGG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-383-6

CACATTTCGTGGAGGTGTTTAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGAAGCATCTATAACCGGGAGGAGTACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACCCGCAGAAGGAGCTCTTGGAGCGGGGG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-383-8

CACATTTCTTGGAGATGTTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-384-34

CACATTTCTTGAAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTTGTGGAAAGATACATCTATAACCGGGAGGAGTACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-awd01

CACATTTCTTGAACGTGGCAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGACAGATACATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACCTGAACCGGCAGAAGGAGATCTTGGAGCAGGAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGGGCGAGAg

CTTCACGGTGCAgCGGCGAg

>lkdrb-awd02

CACATTTCTTGAACGTGGCAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGACAGATACATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACctGAACCGGCAGAAGGAGATCTTGGAGCAGGAG

CGGGCCGCGGTGGACACcTACTGCAGACACAACTACGGGGTGattGAGAg

CTTCACGGTGCAgCGGCGAg

>lkdrb-awd03

CACATTTCgTGtACcaGtttAAGggCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGcTtCTGGcgAGAagCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACtgGAACCGGCAGAAGGAGcTCTTGGAGCAGagG

CGGGCCGCGGTGGACACcTAcTGCAGACACAACTACGGGGTGattGAGAg

CTTCACGGTGCAgCGGCGAg

>lkdrb-awd04

CACATTTCTTGAACGTGGCAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGACAGATACATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACCGGCAGAAGGAGATCTTGGAGCAGGAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAg

CTTCACGGTGCAgCGGCGAg

>lkdrb-coy-r

CACATTTCTTGGAGGTGGCAAAGtyCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCcATAACCGGGAGGAGTtCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACgGGCAGAAGGAGcTCTTGGAGCAGGAG

CGGGCcgCGGTGGACACctacTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-coy-v

CACATTTCTTGGAGATGTtAAAGTtCGAGTGCcATTTCACCAACGGGACG

GAGCGGGTGCGGTatcTGGtgAGAgACATCtATAACCGGGAGGAGcACGT

GCGCTTCGACAGCGACGTGGGGGAGTtCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTaCTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAAG

CGGGCCGcGGTGGACACCTACTGCAGACACAACTACGGGGTGattGAGAG

CTTCgCGGTGCAGCGGCGAG

>lkdrb-coy-x

CACATTTCTTGGAGGTGGCAAAGgyCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCtATAACCGGGAGGAGTaCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACcGGCAGAAGGAGaTCTTGGAGCAGGAG

CGGGCaaCGGTGGACACggtgTGCAGACACAACTACgGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-015v-c13

CACATTTCTTGAAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTTCTGGTGAGAGACATCTATAACCGGGAGGAGCACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACGGGCAGAAGGAGCTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-01802

CACATTTCTTGGAGGTGGCAAAGTCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGGCGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAAG

CGGGCCGAGGTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-048v

CACATTTCTTGGAGATGtTAAAGTcCGAGTGCtATTTCACCAACGGGACG

GAGCGGGTGCGGTtcgTGgaaAGAtACATCcATAACCGGGAGGAGcaCgT

GCGCTTCGACAGCGACGTGGGGGAGTaCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCgGAAG

CGGGCCGaGGTGGACACCTACTGCAGACACAACTACgGGGTGattGAGAG

CTTCgCGGTGCAGCGGCGAG

>lkdrb-2332

CACATTTCTTGGAGaTGGtAAAGttCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTatcTGGAAAGATACATCTATAACCGGGAGGAGatCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCatCGCTGAGTcCTGGAACCgGCAGAAGGAGCTCTTGGAGCaGagG

CGGGCCGcGGTGGACACCTACTGCAGACACAACTACGGGGTGattGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-5078

CACATTTCTTGGAgATGTTAAAGTtcgAgTGCCATtTCAcCAAcggGacg

gaGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGGAG

CGGGCCGCGGTGGACACGGTGTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-9050

CACATTTCTTGGAGaTGGtAAAGTtCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGCTtcTGGtgAGAgACATCtATAACCGGGAGGAGCaCGT

GCGCTTCGACAGCGACGTGGGGGAGTtCCGGGCGGTCACGGAGCTCGGGC

GGCCCGaCGCTGAGTaCTGGAACGGGCAGAAGGAGATCTTGGAGCAGGAG

CGGGCAACGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-a79

CACATTTCGTGAAGATGTTTAAGGCCGAGTGCCATTTcAccAAcGGGAcG

GAGcGGGTGcGGcTTcTGGcGAGAgacATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGOGGGCG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-D7v

CACATTTCTTGGAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATgTGCTGAGAGACATCTATAACCGGGAGGAGATCgT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCAGAAG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACCGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-E17

CACATTTCgTGtAccaGttgAAGcCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGTCGCTGAGTCCTGGAACGGGCAGAAGGAGCTCTTGGAGCAGGAG

CGGGCCgCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-E25

CACATTTCgTGaAGaTGGCtAAGgCCGAGTGCcATTTCACCAACGGGACG

GAGCGGGTGCGGTTtcTGGcAAGAaACATCtATAACCGGGAGGAGtTCGT

GCGCTTCGACAGCGACGTGGGGGAGTtCCGGGCGGTCACGGAGCTCGGGC

GGCCCGaCGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCgGGAG

CGGGCCgCGGTGGACACCTACTGCAGACACAACTACCGGGTGggCGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-E7

CACATTTCTTGaAGaTGGtAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGCTCGT

GCGCTTCGACAGCGACGTGGGGGAGTtCCGGGCGGTCACGGAGCTCGGGC

GGCCCGaCGCTGAGTCCTGGAACcGGCAGAAGGAGcTCTTGGAGCgGaAG

CGGGCcgaGGTGGACACggtgTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-E25-2nd

CACATTTCgTGaAGaTGtttAAGtCCGAGTGCcATTTCACCAACGGGACG

GAGCGGGTGCGGTatcTGGcgAGAgACATCtATAACCGGGAGGAGtTCGT

GCGCTTCGACAGCGACGTGGGGGAGTtCCGGGCGGTCACGGAGCTCGGGC

GGCCCGaCGCTGAGTCCTGGAACcGGCAGAAGGAGcTCTTGGAGCgGGcG

CGGGCcgCGGTGGACACCTACTGCAGACACAACTACcGGGTGggcGAGAG

CTTCACGGTGcAGcGGcGAG

>lkdrb-gw-c

CACATTTCTTGGAGATGTTAAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGGTGAGAGACATCTATAACCGGGAGGAGTTGGT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTACTGGAACGGGCAGAAGGAGATCTTGGAGCGGAGG

CGGGCCGAGCTGGACACGGTGTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-gw-n

CACATTTCTTGGAGATGTTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGTTCTTGGAGCAGAGG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGGGCGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-307

CACATTTCTTGaAGATGtcAAAGTCCGAGTGCtATTTCACCAACGGGACG

GAGCGGGTGCGGttggTGGaaAGAtgCATCTATAACCGGGAGGAGtaCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCtcgGCTGAGTcCTGGAACGGGCAGAAGGAGtTCTTGGAGCAGAaG

CGGGCCGaGGTGGACACggtgTGCAGACACAACTACGGGGTGggcGAGAG

CTTCaCGGTGCAGCGGCGAG

>lkdrb-048v2

CACATTTCTTGGAGATGtTAAAGTcCGAGTGCtATTTCACCAACGGGACG

GAGCGGGTGCGGTtcgTGgaaAGAtACATCcATAACCGGGAGGAGcaCgT

GCGCTTCGACAGCGACGTGGGGGAGTaCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCgGAAG

CGGGCCGaGGTGGACACCTACTGCAGACACAACTACgGGGTGattGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-7573

CACATTTCTTGGAGGTGGCAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCtATAACCGGGAGGAGTaCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCgCGaCGCTGAGTCCTGGAACcGGCAGAAGGAGCTCTTGGAGCgGaAG

CGGGCcgCGGTGGACACCTACTGCAGACACAACTACcGGGTGggcGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-7669

CACATTTCTTGGAGaTGGtAAAGTCCGAGTGCTATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGctCGT

GCGCTTCGACAGCGACGTGGGGGAGTaCCGGGCGGTCACGGAGCTCGGGC

GGCCCGACGCTGAGTCCTGGAACCGGCAGAAGGAGcTCTTGGAGCGGAAG

CGGGCCGaGGTGGACACggtgTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb-3166

CACATTTCGTGAGGATGTATAAGGCCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTaTCTGatGAGAgaCATCTATAACCGGGAGGAGTTCGC

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCGCGACGCTGAGTCCTGGAACCGGCAGAAGGAGCTCTTGGAGCGGAGG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrb3180

CACATTTCTTGGAGGTGGCAAAGTCCGAGTGCtATTTCACCAACGGGACG

GAGCGGGTGCGGTTCGTGGAAAGATACATCCATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCtcgGCTGAGTCCTGGAACgGGCAGAAGGAGaTCTTGGAGCaGgAG

CGGGCaacGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCACGGTGCAGCGGCGAG

>lkdrbper475

CACATTTCTTGaAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGtTggTGGaaAGAGACATCTATAACCGGGAGGAGtACGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCtcgGCTGAGTcCTGGAACcGGCAGAAGGAGtTCTTGGAGCAGAGG

CGGGCCGcGGTGGACACctacTGCAGACACAACTACGGGGTGggCGAGAG

CTTCaCGGTGCAGCGGCGAG

>drb-lk-ew31

CACATTTCGTGTACCAGTTTAAGGGCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTTTCTGGCGAGAAGCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCATCGCTGAGTCCTGGAACCGGCAGAAGGAGTTCTTGGAGCGGAGG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

cTTCACGGTGCAGcggcgag

>drb-lk-ew56b

CACATTTCtTGgAggtGgcaAAGtcCGAGTGCtATTTCACCAACGGGACG

GAGCGGGTGCGGTTcgTGGaaAGAtaCATCcATAACCGGGAGGAGaaCGT

GCGCTTCGACAGCGACGTGGGGGAGTtCCGGGCGGTCACGGAGCTCGGGC

GGCCCgaCGCTGAGTaCTGGAACgGGCAGAAGGAGcTCTTGGAGCaGAaG

CGGGCCGcGGTGGACACCTACTGCAGACACAACTACGGGGTGggcGAGAG

cTTCACGGTGCAGcggcgag

>drb-lk-ew73b

CACATTTCGTGaggatGTTTAAGGCCGAGTGCtATTTCACCAACGGGACG

GAGCGGGTGCGGTTggTGGaaAGAgaCATCTATAACCGGGAGGAGTTCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCgaCGCTGAGTaCTGGAACgGGCAGAAGGAGcTCTTGGAGCaGAGG

CGGGCCGAGGTGGACACCTACTGCAGACACAACTACcGGGTGggcGAGAG

cTTCACGGTGcAGcggcgag

>drb-lk-ew88b

CACATTTCgTGaggatGTTTAAGGcCGAGTGCtATTTCACCAACGGGACG

GAGCGGGTGCGGTTggTGGaaAGAgaCATCTATAACCGGGAGGAGTaCGT

GCGCTTCGACAGCGACGTGGGGGAGTACCGGGCGGTCACGGAGCTCGGGC

GGCCCATCGCTGAGTCCTGGAACCGGCAGAAGGAGTTCTTGGAGCaGAGG

CGGGCCGcGGTGGACACCTACTGCAGACACAACTACcGGGTGggCGAGAG

cTTCACGGTGCAGcggcgag

>drb-lk-8187

CACATTTCTTGGAGATGGTAAAGTTCGAGTGCCATTTCACCAACGGGACG

GAGCGGGTGCGGTATCTGGCGAGAGACATCTATAACCGGGAGGAGATCCT

GCGCTTCGACAGCGACGTGGGGGAGTTCCGGGCGGTCACGGAGCTCGGGC

GGCCCATCGCTGAGTCCTGGAACCGGCAGAAGGAGATCTTGGAGCAGAGG

CGGGCCGCGGTGGACACCTACTGCAGACACAACTACGGGGTGATTGAGAG

CTTCGCGGTGCAGcGGCgAg