Systems and Methods for Expression-Based Discrimination of Distinct Clinical Disease States in Prostate Cancer

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of Application No. PCT/CA2009/000694 filed May 28, 2009, now pending, which claims priority benefit of U.S. Provisional Application No. 61/056,827, filed May 28, 2008, the entire contents both of which are incorporated herein by reference.

FIELD OF THE INVENTION

This invention relates to the field of diagnostics and in particular to systems and methods for classifying prostate cancer into distinct clinical disease states.

BACKGROUND

Prostate cancer is the most common malignancy affecting U.S. men, with approximately 240,000 new cases diagnosed each year. The incidence of prostate cancer is increasing, in part due to increased surveillance efforts from the application of routine molecular testing such as prostate-specific antigen (PSA). For most men, prostate cancer is a slow-growing, organ-confined or localized malignancy that poses little risk of death. The most common treatments for prostate cancer in the U.S. are surgical procedures such as radical prostatectomy, where the entire prostate is removed from the patient. This procedure on its own is highly curative for most but not all men.

The vast majority of deaths from prostate cancer occur in patients with metastasis, believed to be present already at the time of diagnosis in the form of clinically undetectable micro-metastases. In these patients, it is clear that prostatectomy alone is not curative and additional therapies such as anti-androgen or radiation therapy are required to control the spread of disease and extend the life of the patient.

Most prostatectomy patients however face uncertainty with respect to their prognosis after surgery: whether or not the initial surgery will be curative several years from the initial treatment because the current methods for assessment of the clinical risk such as the various pathological (e.g., tumor stage), histological (e.g., Gleason's), clinical (e.g., Kattan nomogram) and molecular biomarkers (e.g., PSA) are not reliable predictors of prognosis, specifically disease progression. Routine PSA testing has certainly increased surveillance and early-detection rates of prostate cancer and this has resulted in an increased number of patients being treated but not significantly decreased the mortality rate.

Despite the controversies surrounding PSA testing as a screening tool, most physicians confidently rely on PSA testing to assess pre-treatment prognosis and to monitor disease progression after initial therapy. Successive increases in PSA levels above a defined threshold value or variations thereof (i.e. ‘Rising-PSA’), also known as biochemical recurrence has been shown to be correlated to disease progression after first-line therapy (e.g., prostatectomy, radiation and brachytherapy). However, less than a ⅓ of patients with ‘rising-PSA’ will eventually be diagnosed with systemic or metastatic disease and several studies have shown that after long-term follow up, the majority will never show any symptoms of disease progression aside from increases in PSA measurement. The limitations of using the PSA biomarker and the absence of additional biomarkers for predicting disease recurrence have led to the development of statistical models combining several clinical and pathological features including PSA results. Several of these ‘nomograms’ have been shown to improve the predictive power for disease recurrence in individual patients over any single independent variable. These models (see Citation #14) are used routinely in the clinic and are currently the best available tools for prediction of outcomes, although they do not provide high levels of accuracy for groups of patients with highly similar histological/pathological features or those at ‘intermediate’ risk of disease recurrence after prostatectomy.

The use of quantitative molecular analyses has the potential to increase the sensitivity, specificity and/or overall accuracy of disease prognosis and provide a more objective basis for determination of risk stratification as compared to conventional clinical-pathological risk models (see Citation #13). The PSA test demonstrates the deficiencies of relying on the measurement of any single biomarker in clinically heterogeneous and complex prostate cancer genomes. Therefore, genomic-based approaches measuring combinations of biomarkers or a signature of disease recurrence are currently being investigated as better surrogates for predicting disease outcome (see Citations # 1-13). For prostate cancer patients these efforts are aimed at reducing the number of unnecessary surgeries for patients without progressive disease and avoid inadvertent under-treatment for higher risk patients. To date, genomic profiling efforts to identify DNA-based (e.g., copy-number alterations, methylation changes), RNA-based (e.g., gene or non-coding RNA expression) or protein-based (e.g., protein expression or modification) signatures, useful for disease prognosis have not however resulted in widespread clinical use.

There are several key reasons explaining why prior genomic profiling methods for prostate cancer have not yet been incorporated in the clinic. These include the small sample sizes typical of individual studies, coupled with variations due to differences in study protocols, clinical heterogeneity of patients and lack of external validation data, which combined have made identifying a robust and reproducible disease signature elusive. Specifically for gene or RNA expression based prognostic models; the mitigating technological limitations include the quality and quantity of RNA that can be isolated from routine clinical samples. Routine clinical samples of prostate cancer include needle-biopsies and surgical resections that have been fixed in formalin and embedded in paraffin wax (FFPE). FFPE-derived RNA is typically degraded and fragmented to between 100-300 bp in size and without poly-A tails making it of little use for traditional 3′-biased gene expression profiling, which requires larger microgram quantities of RNA with intact poly-A tails to prime cDNA synthesis.

Furthermore, as <2% of the genome encodes for protein, traditional gene expression profiling in fact captures only a small fraction of the transcriptome and variation in expression as most RNA molecules that are transcribed are not translated into protein but serve other functional roles and non-coding RNAs are the most abundant transcript species in the genome.

This background information is provided for the purpose of making known information believed by the applicant to be of possible relevance to the present invention. No admission is necessarily intended, nor should be construed, that any of the preceding information constitutes prior art against the present invention.

SUMMARY OF THE INVENTION

An object of the present invention is to provide systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer. In accordance with one aspect of the present invention, there is provided a system for expression-based assessment of risk of prostate cancer recurrence after prostatectomy, said system comprising one or more polynucleotides, each of said polynucleotides capable of specifically hybridizing to a RNA transcript of a gene selected from the group of genes set forth in Table 3 and/or 6.

In accordance with another aspect of the present invention, there is provided a nucleic acid array for expression-based assessment of prostate cancer recurrence risk, said array comprising at least ten probes immobilized on a solid support, each of said probes being between about 15 and about 500 nucleotides in length, each of said probes being derived from a sequence corresponding to, or complementary to, a transcript of a gene selected from the group of genes set forth in Table 3 and/or 6, or a portion of said transcript.

In accordance with another aspect of the present invention, there is provided a method for expression-based assessment of prostate cancer recurrence, said method comprising: (a) determining the expression level of one or more transcripts of one or more genes in a test sample obtained from said subject to provide an expression pattern profile, said one or more genes selected from the group of genes set forth in Table 3 and/or 6, and (c) comparing said expression pattern profile with a reference expression pattern profile.

In accordance with another aspect of the present invention, there is provided a kit for characterizing the expression of one or more nucleic acid sequences depicted in SEQ ID NOs: 1-2114 comprising one or more nucleic acids selected from (a) a nucleic acid depicted in any of SEQ ID NOs: 1-2114; (b) an RNA form of any of the nucleic acids depicted in SEQ ID NOs: 1-2114; (c) a peptide nucleic acid form of any of the nucleic acids depicted in SEQ ID NOs: 1-2114; (d) a nucleic acid comprising at least 20 consecutive bases of any of (a-c); (e) a nucleic acid comprising at least 25 consecutive bases having at least 90% sequence identity to any of (a-c); or (f) a complement to any of (a-e); and optionally instructions for correlating the expression level of said one or more nucleic acid sequences with the disease state of prostate cancer tissue.

In accordance with another aspect of the present invention, there is provided an array of probe nucleic acids certified for use in expression-based assessment of prostate cancer recurrence risk, wherein said array comprises at least two different probe nucleic acids that specifically hybridize to corresponding different target nucleic acids depicted in one of SEQ ID NOs: 1-2114, an RNA form thereof, or a complement to either thereof.

In accordance with another aspect of the present invention, there is provided a device for classifying a biological sample from a prostate cancer as recurrent or non-recurrent, the device comprising means for measuring the expression level of one or more transcripts of one or more genes selected from the group of genes set forth in Table 3 and/or 6; means for correlating the expression level with a classification of prostate cancer status; and means for outputting the prostate cancer status.

In accordance with another aspect of the present invention, there is provided a computer-readable medium comprising one or more digitally-encoded expression pattern profiles representative of the level of expression of one or more transcripts of one or more genes selected from the group of genes set forth in Table 3 and/or 6, each of said one or more expression pattern profiles being associated with a value wherein each of said values is correlated with the presence of recurrent or non-recurrent prostate cancer.

BRIEF DESCRIPTION OF THE DRAWINGS

These and other features of the invention will become more apparent in the following detailed description in which reference is made to the appended drawings.

FIG. 1. A) Principle components analysis (PCA) of 2,114 RNAs identified to be differentially expressed between tumors from patients with differing clinical outcome (see Table 2 for comparisons evaluated), PCA plot of 22 prostate cancer tumors shows tight clustering of samples by clinical outcome of patients (circles, NED; diamonds, PSA; squares, SYS). B) Two-way hierarchical clustering dendrogram and expression matrix of 526 target sequences (Table 4) RNAs filtered using linear regression (p<0.01) to identify RNAs that followed either SYS>PSA>NED or NED>PSA>SYS trend in differential expression. C) Two-way hierarchical clustering dendrogram and expression matrix of 148 target sequences (Table 5), a subset of the most differentially expressed transcripts between patients with clinically significant ‘recurrent’ (i.e., ‘SYS’) and ‘non-recurrent’ (i.e., ‘PSA’ and ‘NED’) disease as filtered using a t-test (p<0.001). For B) and C), sample and RNAs were optimally ordered using Pearson's correlation distance metric with complete-linkage cluster distances and the expression of each RNA in each sample was normalized in the heatmap by the number of standard deviations above (blacker) and below (whiter) the median expression value (grey) across all samples.

FIG. 2. Histograms showing distribution patient's tumor expression levels of a ‘metagene’ generated from a linear combination of the 526 RNAs for each clinical group. The histograms bin samples with similar metagene expression values and significantly separate three modes of patient metagene scores (ANOVA, p<0.000001) corresponding to the three clinical status groups evaluated.

FIG. 3. Scatter plots summarizing the mean (±standard deviation) of metagene expression values for tumor samples from patients in the three clinical status groups (NED; PSA; SYS). Metagenes were generated from a linear combinations of 6 (▴), 18 (♦) or 20 (▪) RNAs and demonstrate highly significant differential expression between clinical groups (ANOVA, p<0.000001).

FIG. 4. Box plots showing interquartile range and distribution of ‘POP’ scores for each clinical group using an 18-target sequence metagene (Table 7) to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. T-tests were used to evaluate the statistical significance of differences in POP scores between NED and PSA (*) as well as between PSA and SYS (**) clinical groups (p<7×10⁻⁷ and p<1×10⁻⁶, respectively).

FIG. 5. Box plots showing interquartile range and distribution of ‘POP’ scores for each clinical group using a 10-target sequence metagene (Table 9) to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. T-tests were used to evaluate the statistical significance of differences in POP scores between ‘recurrent’ (i.e., ‘SYS’) and non-recurrent (i.e., ‘PSA’ and ‘NED’) patient groups (**, p<4×10⁻¹⁰).

FIG. 6. Box plots showing interquartile range and distribution of ‘POP’ scores for each clinical group using a 41-target sequence metagene (Table 10) to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. T-tests were used to evaluate the statistical significance of differences in POP scores between ‘recurrent’ (i.e., ‘SYS’) and non-recurrent (i.e., ‘PSA’ and ‘NED’) patient groups (**, p<2×10⁻¹¹).

FIG. 7. Box plots showing interquartile range and distribution of ‘POP’ scores for each clinical group using a 148-target sequence metagene to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. T-tests were used to evaluate the statistical significance of differences in POP scores between ‘recurrent’ (i.e., ‘SYS’) and non-recurrent (i.e., ‘PSA’ and ‘NED’) patient groups (**, p<9×10⁻¹²).

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides a system and method for assessing prostate cancer recurrence risk by distinguishing clinically distinct disease states in men with prostate cancer at the time of initial diagnosis or surgery. The system and methods are based on the identification of gene transcripts following a retrospective analysis of tumor samples that are differentially expressed in prostate cancer in a manner dependent on prostate cancer aggressiveness as indicated by long-term post-prostatectomy clinical outcome. These gene transcripts can be considered as a library which can be used as a resource for the identification of sets of specific target sequences (“prostate cancer prognostic sets”), which may represent the entire library of gene transcripts or a subset of the library and the detection of which is indicative of prostate cancer recurrence risk. The invention further provides for probes capable of detecting these target sequences and primers that are capable of amplifying the target sequences.

In accordance with one embodiment of the invention, the system and method for assessing prostate cancer recurrence risk are prognostic for a post surgery clinical outcome selected from no evidence of disease (‘NED’), biochemical relapse (two successive increases in prostate-specific antigen levels; (‘PSA’) and systemic prostate cancer systemic metastases (‘SYS’).

In accordance with one embodiment of the invention, the target sequences comprised by the prostate cancer prognostic set are sequences based on or derived from the gene transcripts from the library, or a subset thereof. Such sequences are occasionally referred to herein as “probe selection regions” or “PSRs.” In another embodiment of the invention, the target sequences comprised by the prostate classification set are sequences based on the gene transcripts from the library, or a subset thereof, and include both coding and non-coding sequences.

In one embodiment, the systems and methods provide for the molecular analysis of the expression levels of one or more of the target sequences as set forth in SEQ ID NOs: 1-2114 (Table 4). Increased relative expression of one or more target sequences in a ‘NED’ Group corresponding to the sequences as set forth in SEQ ID NOs: 1-913 is indicative of or predictive of a non-recurrent form of prostate cancer and can be correlated with an increased likelihood of a long-term NED prognosis or low risk of prostate cancer recurrence. Increased relative expression of one or more target sequences in a ‘SYS’ Group corresponding to the sequences as set forth in SEQ ID NOs: 914-2114 is indicative of or predictive of an aggressive form of prostate cancer and can be correlated with an increased likelihood of a long-term SYS prognosis or high risk of prostate cancer recurrence. Optionally, intermediate relative levels of one or more target sequences in a ‘PSA’ Group corresponding to target sequences set forth in Table 7 is indicative of or predictive of biochemical recurrence. Subsets and combinations of these target sequences or probes complementary thereto may be used as described herein.

Before the present invention is described in further detail, it is to be understood that this invention is not limited to the particular methodology, compositions, articles or machines described, as such methods, compositions, articles or machines can, of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention.

DEFINITIONS

Unless defined otherwise or the context clearly dictates otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In describing the present invention, the following terms will be employed, and are intended to be defined as indicated below.

The term “polynucleotide” as used herein refers to a polymer of greater than one nucleotide in length of ribonucleic acid (RNA), deoxyribonucleic acid (DNA), hybrid RNA/DNA, modified RNA or DNA, or RNA or DNA mimetics, including peptide nucleic acids (PNAs). The polynucleotides may be single- or double-stranded. The term includes polynucleotides composed of naturally-occurring nucleobases, sugars and covalent internucleoside (backbone) linkages as well as polynucleotides having non-naturally-occurring portions which function similarly. Such modified or substituted polynucleotides are well-known in the art and for the purposes of the present invention, are referred to as “analogues.”

“Complementary” or “substantially complementary” refers to the ability to hybridize or base pair between nucleotides or nucleic acids, such as, for instance, between a sensor peptide nucleic acid or polynucleotide and a target polynucleotide. Complementary nucleotides are, generally, A and T (or A and U), or C and G. Two single-stranded polynucleotides or PNAs are said to be substantially complementary when the bases of one strand, optimally aligned and compared and with appropriate insertions or deletions, pair with at least about 80% of the bases of the other strand, usually at least about 90% to 95%, and more preferably from about 98 to 100%.

Alternatively, substantial complementarity exists when a polynucleotide will hybridize under selective hybridization conditions to its complement. Typically, selective hybridization will occur when there is at least about 65% complementarity over a stretch of at least 14 to 25 bases, for example at least about 75%, or at least about 90% complementarity. See, M. Kanehisa Nucleic Acids Res. 12:203 (1984).

“Preferential binding” or “preferential hybridization” refers to the increased propensity of one polynucleotide to bind to its complement in a sample as compared to a noncomplementary polymer in the sample.

Hybridization conditions will typically include salt concentrations of less than about 1M, more usually less than about 500 mM, for example less than about 200 mM. In the case of hybridization between a peptide nucleic acid and a polynucleotide, the hybridization can be done in solutions containing little or no salt. Hybridization temperatures can be as low as 5° C., but are typically greater than 22° C., and more typically greater than about 30° C., for example in excess of about 37° C. Longer fragments may require higher hybridization temperatures for specific hybridization as is known in the art. Other factors may affect the stringency of hybridization, including base composition and length of the complementary strands, presence of organic solvents and extent of base mismatching, and the combination of parameters used is more important than the absolute measure of any one alone. Other hybridization conditions which may be controlled include buffer type and concentration, solution pH, presence and concentration of blocking reagents to decrease background binding such as repeat sequences or blocking protein solutions, detergent type(s) and concentrations, molecules such as polymers which increase the relative concentration of the polynucleotides, metal ion(s) and their concentration(s), chelator(s) and their concentrations, and other conditions known in the art.

“Multiplexing” herein refers to an assay or other analytical method in which multiple analytes can be assayed simultaneously.

A “target sequence” as used herein (also occasionally referred to as a “PSR” or “probe selection region”) refers to a region of the genome against which one or more probes can be designed. As used herein, a probe is any polynucleotide capable of selectively hybridizing to a target sequence or its complement, or to an RNA version of either. A probe may comprise ribonucleotides, deoxyribonucleotides, peptide nucleic acids, and combinations thereof. A probe may optionally comprise one or more labels. In some embodiments, a probe may be used to amplify one or both strands of a target sequence or an RNA form thereof, acting as a sole primer in an amplification reaction or as a member of a set of primers.

“Having” is an open ended phrase like “comprising” and “including,” and includes circumstances where additional elements are included and circumstances where they are not.

“Optional” or “optionally” means that the subsequently described event or circumstance may or may not occur, and that the description includes instances where the event or circumstance occurs and instances in which it does not.

As used herein ‘NED’ describes a clinically distinct disease state in which patients show no evidence of disease (‘NED’) at least 5 years after surgery, ‘PSA’ describes a clinically distinct disease state in which patients show biochemical relapse only (two successive increases in prostate-specific antigen levels but no other symptoms of disease with at least 5 years follow up after surgery; ‘PSA’) and ‘SYS’ describes a clinically distinct disease state in which patients develop biochemical relapse and present with systemic prostate cancer disease or metastases (‘SYS’) within five years after the initial treatment with radical prostatectomy.

As used herein, the term “about” refers to approximately a +/−10% variation from a given value. It is to be understood that such a variation is always included in any given value provided herein, whether or not it is specifically referred to.

Use of the singular forms “a,” “an,” and “the” include plural references unless the context clearly dictates otherwise. Thus, for example, reference to “a polynucleotide” includes a plurality of polynucleotides, reference to “a target” includes a plurality of such targets, reference to “a normalization method” includes a plurality of such methods, and the like. Additionally, use of specific plural references, such as “two,” “three,” etc., read on larger numbers of the same subject, unless the context clearly dictates otherwise.

Terms such as “connected,” “attached,” “linked” and “conjugated” are used interchangeably herein and encompass direct as well as indirect connection, attachment, linkage or conjugation unless the context clearly dictates otherwise.

Where a range of values is recited, it is to be understood that each intervening integer value, and each fraction thereof, between the recited upper and lower limits of that range is also specifically disclosed, along with each subrange between such values. The upper and lower limits of any range can independently be included in or excluded from the range, and each range where either, neither or both limits are included is also encompassed within the invention. Where a value being discussed has inherent limits, for example where a component can be present at a concentration of from 0 to 100%, or where the pH of an aqueous solution can range from 1 to 14, those inherent limits are specifically disclosed. Where a value is explicitly recited, it is to be understood that values which are about the same quantity or amount as the recited value are also within the scope of the invention, as are ranges based thereon. Where a combination is disclosed, each subcombination of the elements of that combination is also specifically disclosed and is within the scope of the invention. Conversely, where different elements or groups of elements are disclosed, combinations thereof are also disclosed. Where any element of an invention is disclosed as having a plurality of alternatives, examples of that invention in which each alternative is excluded singly or in any combination with the other alternatives are also hereby disclosed; more than one element of an invention can have such exclusions, and all combinations of elements having such exclusions are hereby disclosed.

Prostate Cancer Prognostic System

The system of the present invention is based on the identification of a library of gene and RNA transcripts that are differentially expressed in prostate cancer in a manner dependent on prostate cancer aggressiveness as indicated by the post-prostatectomy clinical outcome of the patient. For example, relative over expression of one or more of the gene transcripts in a prostate cancer sample compared to a reference sample or expression profile or signature there from may be prognostic of a clinically distinct disease outcome post-prostatectomy selected from no evidence of disease (‘NED’), biochemical relapse (‘PSA’) and prostate cancer disease systemic recurrence or metastases (‘SYS’). The reference sample can be, for example, from prostate cancer sample(s) of one or more references subject(s) with a known post-prostatectomy clinical outcomes. The reference expression profile or signature may optionally be normalized to one or more appropriate reference gene transcripts. Alternatively or in addition to, expression of one or more of the gene transcripts in a prostate cancer sample may be compared to an expression profile or signature from normal prostate tissue.

Expression profiles or signatures from prostate cancer samples may be normalized to one or more house keeping gene transcripts such that normalized over and/or under expression of one or more of the gene transcripts in a sample may be indicative of a clinically distinct disease state or prognosis.

Prostate Prognostic Library

The Prostate Prognostic Library in accordance with the present invention comprises one or more gene or RNA transcripts whose relative and/or normalized expression is indicative of prostate cancer recurrence and which may be prognostic for post-prostatectomy clinical outcome of a patient. Exemplary RNA transcripts that showed differential expression in prostate cancer samples from patients with clinically distinct disease outcomes after initial treatment with radical prostatectomy are shown in Table 3. In one embodiment of the invention, the library comprises one or more of the gene transcripts of the genes listed in Table 3.

In one embodiment, the library comprises at least one transcript from at least one gene selected from those listed in Table 3. In one embodiment, the library comprises at least one transcript from each of at least 5 genes selected from those listed in Table 3. In another embodiment, the library comprises at least one transcript from each of at least 10 genes selected from those listed in Table 3. In a further embodiment, the library comprises at least one transcript from each of at least 15 genes selected from those listed in Table 1. In other embodiments, the library comprises at least one transcript from each of at least 20, at least 25, at least 30, at least 35, at least 40, at least 45, at least 50, at least 55, at least 60 and at least 65 genes selected from those listed in Table 3. In a further embodiment, the library comprises at least one transcript from all of the genes listed in Table 3. In a further embodiment, the library comprises at all transcripts from all of the genes listed in Table 3.

In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of [NM_—001004722]; [NM_—001005522]; [NM_—001013671]; [NM_—001033517]; [NM_—183049]; [NM_—212559]; 5′-3′ exoribonuclease 1; A kinase (PRKA) anchor protein (yotiao) 9; AarF domain containing kinase 4; Abhydrolase domain containing 3; Aconitase 1, soluble; Actinin, alpha 1; ADAM metallopeptidase domain 19 (meltrin beta); Adaptor-related protein complex 1, gamma 2 subunit; Adenosine deaminase, RNA-specific, B2 (RED2 homolog rat); Adenylate cyclase 3; ADP-ribosylation factor GTPase activating protein 3; ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); ADP-ribosylation factor-like 4D; Adrenergic, beta, receptor kinase 2; AF4/FMR2 family, member 3; Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); Anaphase promoting complex subunit 1; Ankyrin 3, node of Ranvier (ankyrin G); Ankyrin repeat domain 15; Ankyrin repeat domain 28; Annexin A1; Annexin A2; Anterior pharynx defective 1 homolog B (C. elegans); Anthrax toxin receptor 1; Antizyme inhibitor 1; Arachidonate 12-lipoxygenase, 12R type; Arginine vasopressin receptor 1A; Arginine-glutamic acid dipeptide (RE) repeats; ARP3 actin-related protein 3 homolog (yeast); Arrestin 3, retinal (X-arrestin); Arrestin domain containing 1; Aryl hydrocarbon receptor interacting protein-like 1; Aryl hydrocarbon receptor nuclear translocator; Ataxin 1; ATM/ATR-Substrate Chk2-Interacting Zn2+-finger protein; ATPase, Class I, type 8B, member 1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATP-binding cassette, sub-family F (GCN20), member 1; Autism susceptibility candidate 2; Baculoviral IAP repeat-containing 6 (apollon); Basonuclin 2; Brain-specific angiogenesis inhibitor 3; Bromodomain containing 7; Bromodomain containing 8; Bromodomain PHD finger transcription factor; BTB (POZ) domain containing 16; BTB (POZ) domain containing 7; Calcium activated nucleotidase 1; Calcium binding protein P22; Calcium channel, voltage-dependent, beta 4 subunit; Calcium channel, voltage-dependent, L type, alpha 1C subunit; Calcium channel, voltage-dependent, L type, alpha 1D subunit; Calcyclin binding protein; Calmodulin 1 (phosphorylase kinase, delta); Calsyntenin 1; Carbonyl reductase 3; Cardiolipin synthase 1; Carnitine palmitoyltransferase 1A (liver); Casein kinase 1, delta; Casein kinase 1, gamma 1; Casein kinase 1, gamma 3; Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); CD109 molecule; CD99 molecule-like 2; CDK5 regulatory subunit associated protein 2; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2; Cell adhesion molecule 1; Cell division cycle and apoptosis regulator 1; Centrosomal protein 70 kDa; Chloride channel 3; Chromodomain helicase DNA binding protein 2; Chromodomain helicase DNA binding protein 6; Chromodomain protein, Y-like 2; Chromosome 1 ORF 116; Chromosome 1 ORF 52; Chromosome 10 ORF 118; Chromosome 12 ORF 30; Chromosome 13 ORF 23; Chromosome 16 ORF 45; Chromosome 18 ORF 1; Chromosome 18 ORF 1; Chromosome 18 ORF 1; Chromosome 18 ORF 1; Chromosome 18 ORF 17; Chromosome 2 ORF 3; Chromosome 20 ORF 133; Chromosome 21 ORF 25; Chromosome 21 ORF 34; Chromosome 22 ORF 13; Chromosome 3 ORF 26; Chromosome 5 ORF 3; Chromosome 5 ORF 33; Chromosome 5 ORF 35; Chromosome 5 ORF 39; Chromosome 7 ORF 13; Chromosome 7 ORF 42; Chromosome 9 ORF 3; Chromosome 9 ORF 94; Chromosome Y ORF 15B; Chymase 1, mast cell; Citrate lyase beta like; Class II, major histocompatibility complex, transactivator; C-Maf-inducing protein; Coatomer protein complex, subunit alpha; Cofilin 2 (muscle); Coiled-coil domain containing 50; Coiled-coil domain containing 7; Coiled-coil-helix-coiled-coil-helix domain containing 4; Cold shock domain containing E1, RNA-binding; Collagen, type XII, alpha 1; Complement component 1, r subcomponent-like; Core-binding factor, runt domain, alpha subunit 2; translocated to, 2; CREB binding protein (Rubinstein-Taybi syndrome); CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; CUG triplet repeat, RNA binding protein 2; Cullin 3; Cut-like 2; Cyclin F; Cyclin Y; Cysteine-rich with EGF-like domains 1; Cytochrome P450, family 4, subfamily F, polypeptide 11; Cytoplasmic FMR1 interacting protein 2; DAZ interacting protein 1-like; DCP2 decapping enzyme homolog (S. cerevisiae); DEAD box polypeptide 47; DEAD box polypeptide 5; DEAD box polypeptide 52; DEAD box polypeptide 56; Death inducer-obliterator 1; Dedicator of cytokinesis 2; DEP domain containing 1B; DEP domain containing 2; DEP domain containing 6; Development and differentiation enhancing factor 1; Diacylglycerol lipase, alpha; Diaphanous homolog 2 (Drosophila); Dickkopf homolog 3; Dihydropyrimidine dehydrogenase; Dipeptidyl-peptidase 10; Discs, large homolog 2, chapsyn-110; Dishevelled, dsh homolog 2; DnaJ (Hsp40) homolog, subfamily C, member 6; Dpy-19-like 3; Dual specificity phosphatase 5; Ectodysplasin A receptor; Ectonucleoside triphosphate diphosphohydrolase 7; EGFR-coamplified and overexpressed protein; ELL associated factor 1; Emopamil binding protein (sterol isomerase); Enabled homolog; Ephrin-A5; ER lipid raft associated 1; Erythroblast membrane-associated protein (Scianna blood group); Erythrocyte membrane protein band 4.1 like 4A; Etoposide induced 2.4 mRNA; Eukaryotic translation initiation factor 4E family member 3; FAD1 flavin adenine dinucleotide synthetase homolog; Family with sequence similarity 110, member A; Family with sequence similarity 114, member A1; Family with sequence similarity 135, member A; Family with sequence similarity 40, member A; Family with sequence similarity 80, member B; F-box and leucine-rich repeat protein 11; F-box and leucine-rich repeat protein 7; F-box protein 2; Ferritin, heavy polypeptide 1; Fibronectin type III domain containing 3A; Fibronectin type III domain containing 3B; Fibulin 1; FLJ25476 protein; FLJ41603 protein; Forkhead box J3; Forkhead box J3; Forkhead box K1; Forkhead box P1; Frizzled homolog 3; Frizzled homolog 5; G protein-coupled receptor kinase interactor 2; GABA A receptor, delta; GATA binding protein 2; GDNF family receptor alpha 2; Gelsolin (amyloidosis, Finnish type); Genethonin 1; Glucose phosphate isomerase; Glucose-fructose oxidoreductase domain containing 1; Glucosidase, beta (bile acid) 2; Glutamate dehydrogenase 1; Glutaminase; Glutamyl aminopeptidase (aminopeptidase A); Glutathione reductase

Glycogen synthase kinase 3 beta; Grainyhead-like 2; Gremlin 1, cysteine knot superfamily, homolog; GTPase activating protein (SH3 domain) binding protein 1; Hairy/enhancer-of-split related with YRPW motif 2; Heparan sulfate 6-O-sulfotransferase 3; Hermansky-Pudlak syndrome 5; Heterogeneous nuclear ribonucleoprotein C(C1/C2)
Hippocalcin-like 1; Histocompatibility (minor) 13; Histone cluster 1, H3d; Histone deacetylase 6; Homeobox A1; Homeobox and leucine zipper encoding; Host cell factor C1 (VP16-accessory protein); Hyaluronan binding protein 4; Hyperpolarization activated cyclic nucleotide-gated potassium channel 3; Hypothetical gene supported by AK128346; Hypothetical LOC51149; Hypothetical protein FLJ12949; Hypothetical protein FLJ20035; Hypothetical protein FLJ20309; Hypothetical protein FLJ38482; Hypothetical protein HSPC148; Hypothetical protein LOC130576; Hypothetical protein LOC285908; Hypothetical protein LOC643155; Iduronidase, alpha-L-IKAROS family zinc finger 1 (Ikaros); IlvB (bacterial acetolactate synthase)-like; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Inositol polyphosphate-4-phosphatase, type II; Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); Integrin, alpha 6; Integrin, alpha 9; Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); Integrin, beta-like 1 (with EGF-like repeat domains); Inter-alpha (globulin) inhibitor H3; Interleukin enhancer binding factor 3, 90 kDa; Intestine-specific homeobox
Intraflagellar transport 172 homolog; Janus kinase 1; Jumonji domain containing 1B; Jumonji domain containing 2B; Jumonji domain containing 2C; Kalirin, RhoGEF kinase; Kallikrein-related peptidase 2; Karyopherin alpha 3 (importin alpha 4); Keratinocyte associated protein 2; KIAA0152; KIAA0241; KIAA0319-like; KIAA0495; KIAA0562; KIAA0564 protein; KIAA1217; KIAA1244; KIAA1244; La ribonucleoprotein domain family, member 1; Lamin A/C; LATS, large tumor suppressor, homolog 2; Leiomodin 3 (fetal); Leptin receptor overlapping transcript-like 1; Leucine rich repeat containing 16; Leucine-rich repeat kinase 1; Leucine-rich repeat-containing G protein-coupled receptor 4; LIM domain 7; Major histocompatibility complex, class II, DR beta 1; Malignant fibrous histiocytoma amplified sequence 1; Maltase-glucoamylase (alpha-glucosidase); Mannosidase, alpha, class 2A, member 1; Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase; MBD2-interacting zinc finger; Melanin-concentrating hormone receptor 1; Methionyl-tRNA synthetase; Methyl CpG binding protein 2; Methyl-CpG binding domain protein 5; Microcephaly, primary autosomal recessive 1; Microseminoprotein, beta-; Microtubule-associated protein 1B; Microtubule-associated protein 2; Minichromosome maintenance complex component 3 associated protein; Mitochondrial ribosomal protein S15; Mohawk homeobox; Monooxygenase, DBH-like 1; MORN repeat containing 1; Muscle RAS oncogene homolog; Muscleblind-like; Myelin protein zero-like 1; Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; Myocyte enhancer factor 2B; Myosin IF; Myosin, heavy chain 3, skeletal muscle, embryonic; N-acetylgalactosaminidase, alpha-; N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits; Nascent polypeptide-associated complex alpha subunit; NECAP endocytosis associated 2; Necdin homolog; Neural precursor cell expressed, developmentally down-regulated 9; Neuregulin 1; Neuron navigator 1; Nibrin; Nicotinamide N-methyltransferase; NIMA (never in mitosis gene a)-related kinase 6; NLR family, CARD domain containing 5; NOL1/NOP2/Sun domain family, member 3; NOL1/NOP2/Sun domain family, member 3; NOL1/NOP2/Sun domain family, member 6; Nuclear receptor coactivator 2; Nuclear receptor coactivator 6; Nuclear receptor subfamily 2, group F, member 2; Nuclear receptor subfamily 3, group C, member 2; Nuclear receptor subfamily 4, group A, member 2; Nuclear transcription factor, X-box binding-like 1; Nucleolar and coiled-body phosphoprotein 1; Overexpressed in colon carcinoma-1; PAN3 polyA specific ribonuclease subunit homolog; PAP associated domain containing 1; Paraoxonase 2; Paraspeckle component 1; PCTAIRE protein kinase 2; Peptidase D; Pericentrin (kendrin); Peroxisomal biogenesis factor 19; PHD finger protein 8; Phosphatidic acid phosphatase type 2 domain containing 3; Phosphatidylinositol 4-kinase, catalytic, alpha polypeptide; Phosphatidylinositol glycan anchor biosynthesis, class O; Phosphatidylinositol transfer protein, beta; Phosphodiesterase 4D, cAMP-specific; Phosphoglucomutase 5; Phosphoglycerate mutase family member 5; Phosphoinositide-3-kinase, class 2, beta polypeptide; Phospholipase A2, group IVB (cytosolic); Phospholipase C, beta 1 (phosphoinositide-specific); Phospholipase C, gamma 2 (phosphatidylinositol-specific); Phosphorylase kinase, beta; Plasminogen activator, tissue; Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45 kDa; Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3; Pleckstrin homology domain containing, family A member 7; Pleckstrin homology domain containing, family G (with RhoGef domain) member 3; Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1; Poly (ADP-ribose) polymerase family, member 16; Poly (ADP-ribose) polymerase family, member 2; Poly(A) polymerase alpha; Poly(A)-specific ribonuclease (deadenylation nuclease); Polymerase (DNA directed) nu; Polymerase (DNA directed), gamma 2, accessory subunit; Polymerase (RNA) II (DNA directed) polypeptide L; Polymerase (RNA) III (DNA directed) polypeptide E; Polymerase I and transcript release factor; Potassium channel tetramerisation domain containing 1; Potassium channel tetramerisation domain containing 2; Potassium channel tetramerisation domain containing 7; Potassium channel, subfamily K, member 1; Presenilin 1; PRKR interacting protein 1; Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2; ProSAPiP1 protein; Prostaglandin E synthase 3 (cytosolic); Protease, serine, 2 (trypsin 2); Protein kinase, Y-linked; Protein phosphatase 1, regulatory (inhibitor) subunit 9A; Protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; Protein phosphatase 4, regulatory subunit 1-like; Protein tyrosine phosphatase, non-receptor type 18 (brain-derived); Protein tyrosine phosphatase, non-receptor type 3; Protein tyrosine phosphatase, receptor type, D; Protein-O-mannosyltransferase 1; Proteolipid protein 2 (colonic epithelium-enriched); Protocadherin 7; Protocadherin gamma subfamily A, 1; PRP6 pre-mRNA processing factor 6 homolog; Putative homeodomain transcription factor 1; RAB GTPase activating protein 1-like; RAB10; RAB30; Rabaptin, RAB GTPase binding effector protein 1; RAD51-like 1; RALBP1 associated Eps domain containing 2; Rap guanine nucleotide exchange factor (GEF) 1; Rapamycin-insensitive companion of mTOR; Ras and Rab interactor 2; Receptor accessory protein 3; Reelin; Replication factor C (activator 1) 3; Replication protein A3; Rho GTPase activating protein 18; Rho guanine nucleotide exchange factor (GEF) 10-like; Rhophilin, Rho GTPase binding protein 1; Ribonuclease H2, subunit B; Ribonuclease P 14 kDa subunit; Ring finger protein 10; Ring finger protein 144; Ring finger protein 44; RNA binding motif protein 16; Roundabout, axon guidance receptor, homolog 1; Roundabout, axon guidance receptor, homolog 2; RUN domain containing 2A; Scinderin; SEC23 interacting protein; Sec61 alpha 2 subunit; Septin 11; Serine/threonine kinase 32A; Serine/threonine kinase 32C; SGT1, suppressor of G2 allele of SKP1; SH3 and PX domains 2A; Signal peptide peptidase 3; Signal transducer and activator of transcription 1, 91 kDa; Single-stranded DNA binding protein 2; Small nuclear ribonucleoprotein polypeptide N; SNF8, ESCRT-II complex subunit, homolog; Sodium channel, voltage-gated, type III, alpha subunit; Solute carrier family 1 (neutral amino acid transporter), member 5; Solute carrier family 16, member 7 (monocarboxylic acid transporter 2); Solute carrier family 2 (facilitated glucose transporter), member 11; Solute carrier family 2 (facilitated glucose transporter), member 11; Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3; Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2; Solute carrier family 30 (zinc transporter), member 6; Solute carrier family 39 (zinc transporter), member 10; Solute carrier family 43, member 1; Solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; SON DNA binding protein; Sortilin-related VPS10 domain containing receptor 3; Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2; Spectrin repeat containing, nuclear envelope 1; Sperm associated antigen 9; Splicing factor 3a, subunit 2, 66 kDa; Splicing factor 3b, subunit 1, 155 kDa; Staphylococcal nuclease and tudor domain containing 1; Staufen, RNA binding protein, homolog 1; Suppression of tumorigenicity 7; Suppressor of variegation 4-20 homolog 1; Synapsin III; Syntaxin 3; Syntaxin 5; Tachykinin receptor 1; TAO kinase 3; TBC1 domain family, member 16; TBC1 domain family, member 19; Testis specific, 10; Tetraspanin 6; Tetratricopeptide repeat domain 23; Thioredoxin-like 2; THUMP domain containing 3; TIMELESS interacting protein; TOX high mobility group box family member 4; Trafficking protein, kinesin binding 1; Transcription factor 7-like 1 (T-cell specific, HMG-box); Transcription factor 7-like 2 (T-cell specific, HMG-box); Translocase of inner mitochondrial membrane 13 homolog; Translocated promoter region (to activated MET oncogene); Translocation associated membrane protein 2; Transmembrane 9 superfamily member 2; Transmembrane emp24 protein transport domain containing 8; Transmembrane emp24-like trafficking protein 10; Transmembrane protein 134; Transmembrane protein 18; Transmembrane protein 18; Transmembrane protein 29; Triadin; Tribbles homolog 1; Trinucleotide repeat containing 6C; Tripartite motif-containing 36; Tripartite motif-containing 61; TRNA methyltransferase 11 homolog; TruB pseudouridine (psi) synthase homolog 2; Tubby like protein 4; Tuftelin 1; Tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin); Tumor necrosis factor receptor superfamily, member 25; Tumor necrosis factor, alpha-induced protein 8; Tyrosine kinase 2; Ubiquinol-cytochrome c reductase core protein I; Ubiquitin specific peptidase 47; Ubiquitin specific peptidase 5 (isopeptidase T); Ubiquitin specific peptidase 8; Ubiquitin-like 7 (bone marrow stromal cell-derived); UBX domain containing 6; UDP-glucose ceramide glucosyltransferase-like 2; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2); Unc-93 homolog B1; UTP6, small subunit (SSU) processome component, homolog; Vacuolar protein sorting 8 homolog; V-akt murine thymoma viral oncogene homolog 1; V-ets erythroblastosis virus E26 oncogene homolog; Viral DNA polymerase-transactivated protein 6; WD repeat domain 33; WD repeat domain 90; Wingless-type MMTV integration site family, member 2B; WW and C2 domain containing 1; Yip1 domain family, member 3; YTH domain family, member 3; Zinc finger and BTB domain containing 10; Zinc finger and BTB domain containing 20; Zinc finger and SCAN domain containing 18; Zinc finger homeodomain 4; Zinc finger protein 14 homolog; Zinc finger protein 335; Zinc finger protein 394; Zinc finger protein 407; Zinc finger protein 608; Zinc finger protein 667; Zinc finger protein 692; Zinc finger protein 718; Zinc finger protein 721; Zinc finger, CCHC domain containing 9; Zinc finger, matrin type 1; Zinc finger, MYND domain containing 11; Zinc finger, ZZ-type containing 3; Zinc fingers and homeoboxes 2; and Zwilch, kinetochore associated, homolog.

In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Tripartite motif-containing 61; Citrate lyase beta like; Ankyrin repeat domain 15; UDP-glucose ceramide glucosyltransferase-like 2; Hypothetical protein FLJ12949; Chromosome 22 open reading frame 13; Phosphatidylinositol glycan anchor biosynthesis, class O; Solute carrier family 43, member 1; Rabaptin, RAB GTPase binding effector protein 1; Zinc finger protein 14 homolog; Hypothetical gene supported by AK128346; Adenylate cyclase 3; Phosphatidylinositol transfer protein, beta; Zinc finger protein 667; Gremlin 1, cysteine knot superfamily, homolog; Ankyrin 3, node of Ranvier (ankyrin G) and Maltase-glucoamylase (alpha-glucosidase).

In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Ankyrin repeat domain 15; Hypothetical protein FLJ12949; Solute carrier family 43, member 1; Thioredoxin-like 2; Polymerase (RNA) II (DNA directed) polypeptide L; Syntaxin 5; Leucine rich repeat containing 16; Calcium channel, voltage-dependent, beta 4 subunit; [NM_—001005522]; G protein-coupled receptor kinase interactor 2; Ankyrin 3, node of Ranvier (ankyrin G); Gremlin 1, cysteine knot superfamily, homolog; Zinc finger protein 667; Hypothetical gene supported by AK128346; Transmembrane 9 superfamily member 2; Potassium channel, subfamily K, member 1; Chromodomain helicase DNA binding protein 2; Microcephaly, primary autosomal recessive 1; Chromosome 21 open reading frame 34 and Dual specificity phosphatase 5.

In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Tripartite motif-containing 61; Citrate lyase beta like; Ankyrin repeat domain 15; Ankyrin 3, node of Ranvier (ankyrin G) and Maltase-glucoamylase (alpha-glucosidase).

In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Ankyrin repeat domain 15; Hypothetical protein FLJ12949; Solute carrier family 43, member 1; Thioredoxin-like 2; Polymerase (RNA) II (DNA directed) polypeptide L; Syntaxin 5; Leucine rich repeat containing 16; Calcium channel, voltage-dependent, beta 4 subunit; [NM_—001005522]; G protein-coupled receptor kinase interactor 2; Ankyrin 3, node of Ranvier (ankyrin G); Gremlin 1, cysteine knot superfamily, homolog; Zinc finger protein 667; Hypothetical gene supported by AK128346; Transmembrane 9 superfamily member 2; Potassium channel, subfamily K, member 1; Chromodomain helicase DNA binding protein 2; Chromosome 9 open reading frame 94; Chromosome 21 open reading frame 34; and Dual specificity phosphatase 5.

In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Citrate lyase beta like; Phosphodiesterase 4D, cAMP-specific; Ectodysplasin A receptor; DEP domain containing 6; Basonuclin 2; Chromosome 2 open reading frame 3; FLJ25476 protein; Staphylococcal nuclease and tudor domain containing 1; Hermansky-Pudlak syndrome 5 and Chromosome 12 open reading frame 30.

In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Tripartite motif-containing 61; Citrate lyase beta like; Adaptor-related protein complex 1, gamma 2 subunit; Kallikrein-related peptidase 2; Phosphodiesterase 4D, cAMP-specific; Cytochrome P450, family 4, subfamily F, polypeptide 11; Ectodysplasin A receptor

Phospholipase C, beta 1; KIAA1244; Paraoxonase 2; Arachidonate 12-lipoxygenase, 12R type; Cut-like 2; Chemokine (C-X-C motif) ligand 12; Rho guanine nucleotide exchange factor (GEF) 5; Olfactory receptor, family 2, subfamily A, member 4; Chromosome 19 open reading frame 42; Hypothetical gene supported by AK128346; Phosphoglucomutase 5; Hyaluronan binding protein 4; NECAP endocytosis associated 2
Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4; Signal transducer and activator of transcription 1; Chromosome 2 open reading frame 3; FLJ25476 protein; Staphylococcal nuclease and tudor domain containing 1; Transmembrane protein 18; Hermansky-Pudlak syndrome 5; Chromosome 12 open reading frame 30; Splicing factor 3b, subunit 1; Cofilin 2; Heparan sulfate 6-O-sulfotransferase 3; Enabled homolog; Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase; Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3; Inositol 1,4,5-triphosphate receptor, type 1; CAP-GLY domain containing linker protein; Transglutaminase 4; MOCO sulphurase C-terminal domain containing 2; 4-hydroxyphenylpyruvate dioxygenase-like; and R3H domain containing 1.

The invention also contemplates that alternative libraries may be designed that include transcripts of one or more of the genes in Table 3, together with additional gene transcripts that have previously been shown to be associated with prostate cancer systemic progression. As is known in the art, the publication and sequence databases can be mined using a variety of search strategies to identify appropriate additional candidates for inclusion in the library. For example, currently available scientific and medical publication databases such as Medline, Current Contents, OMIM (online Mendelian inheritance in man), various Biological and Chemical Abstracts, Journal indexes, and the like can be searched using term or key-word searches, or by author, title, or other relevant search parameters. Many such databases are publicly available, and strategies and procedures for identifying publications and their contents, for example, genes, other nucleotide sequences, descriptions, indications, expression pattern, etc, are well known to those skilled in the art. Numerous databases are available through the internet for free or by subscription, see, for example, the National Center Biotechnology Information (NCBI), Infotrieve, Thomson ISI, and Science Magazine (published by the AAAS) websites. Additional or alternative publication or citation databases are also available that provide identical or similar types of information, any of which can be employed in the context of the invention. These databases can be searched for publications describing altered gene expression between recurrent and non-recurrent prostate cancer. Additional potential candidate genes may be identified by searching the above described databases for differentially expressed proteins and by identifying the nucleotide sequence encoding the differentially expressed proteins. A list of genes whose altered expression is between patients with recurrent disease and non-recurrent prostate cancer is presented in Table 6.

Prostate Cancer Prognostic Sets

A Prostate Prognostic Set comprises one or more target sequences identified within the gene transcripts in the prostate prognostic library, or a subset of these gene transcripts. The target sequences may be within the coding and/or non-coding regions of the gene transcripts. The set can comprise one or a plurality of target sequences from each gene transcript in the library, or subset thereof. The relative and/or normalized level of these target sequences in a sample is indicative of the level of expression of the particular gene transcript and thus of prostate cancer recurrence risk. For example, the relative and/or normalized expression level of one or more of the target sequences may be indicative of an recurrent form of prostate cancer and therefore prognostic for prostate cancer systemic progression while the relative and/or normalized expression level of one or more other target sequences may be indicative of a non-recurrent form of prostate cancer and therefore prognostic for a NED clinical outcome.

Accordingly, one embodiment of the present invention provides for a library or catalog of candidate target sequences derived from the transcripts (both coding and non-coding regions) of at least one gene suitable for classifying prostate cancer recurrence risk. In a further embodiment, the present invention provides for a library or catalog of candidate target sequences derived from the non-coding regions of transcripts of at least one gene suitable for classifying prostate cancer recurrence risk. In still a further embodiment, the library or catalog of candidate target sequences comprises target sequences derived from the transcripts of one or more of the genes set forth in Table 3 and/or Table 6. The library or catalog in affect provides a resource list of transcripts from which target sequences appropriate for inclusion in a Prostate Cancer Prognostic set can be derived. In one embodiment, an individual Prostate Cancer Prognostic set may comprise target sequences derived from the transcripts of one or more genes exhibiting a positive correlation with recurrent prostate cancer. In one embodiment, an individual Prostate Cancer Prognostic Set may comprise target sequences derived from the transcripts of one or more genes exhibiting a negative correlation with recurrent prostate cancer. In one embodiment, an individual Prostate Cancer Prognostic Set may comprise target sequences derived from the transcripts of two or more genes, wherein at least one gene has a transcript that exhibits a positive correlation with recurrent prostate cancer and at least one gene has a transcript that exhibits negative correlation with recurrent prostate cancer.

In one embodiment, the Prostate Cancer Prognostic Set comprises target sequences derived from the transcripts of at least one gene. In one embodiment, the Prostate Cancer Prognostic Set comprises target sequences derived from the transcripts of at least 5 genes. In another embodiment, the Prostate Cancer Prognostic set comprises target sequences derived from the transcripts of at least 10 genes. In a further embodiment, the Prostate Cancer Prognostic set comprises target sequences derived from the transcripts of at least 15 genes. In other embodiments, the Prostate Cancer Prognostic set comprises target sequences derived from the transcripts of at least 20, at least 25, at least 30, at least 35, at least 40, at least 45, at least 50, at least 55, at least 60 and at least 65 genes.

Following the identification of candidate gene transcripts, appropriate target sequences can be identified by screening for target sequences that have been annotated to be associated with each specific gene locus from a number of annotation sources including GenBank, RefSeq, Ensembl, dbEST, GENSCAN, TWINSCAN, Exoniphy, Vega, microRNAs registry and others (see Affymetrix Exon Array design note).

As part of the target sequence selection process, target sequences can be further evaluated for potential cross-hybridization against other putative transcribed sequences in the design (but not the entire genome) to identify only those target sequences that are predicted to uniquely hybridize to a single target.

Optionally, the set of target sequences that are predicted to uniquely hybridize to a single target can be further filtered using a variety of criteria including, for example, sequence length, for their mean expression levels across a wide selection of human tissues, as being representive of transcripts expressed either as novel alternative (i.e., non-consensus) exons, alternative retained introns, novel exons 5′ or 3′ of the gene's transcriptional start site or representing transcripts expressed in a manner antisense to the gene, amongst others.

In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3′ of Replication factor C (activator 1) 3, 38 kDa; 58,123 base pair 3′ of Tripartite motif-containing 61; in intron #3 of Citrate lyase beta like; in intron #2 of Ankyrin repeat domain 15; in exon #1 of UDP-glucose ceramide glucosyltransferase-like 2; in exon of #19 of Hypothetical protein FLJ12949; in intron #4 of Chromosome 22 open reading frame 13; in exon #2 of phatidylinositol glycan anchor biosynthesis, class O; in exon #15 of Solute carrier family 43, member 1; in exon #1 of Rabaptin, RAB GTPase binding effector protein 1; in intron #38 of Maltase-glucoamylase (alpha-glucosidase); in intron #23 of Ankyrin 3, node of Ranvier (ankyrin G); 71,333 base pair 3′ of Gremlin 1, cysteine knot superfamily, homolog; 1,561 base pair of 3′ Zinc finger protein 667; in exon #4 of Phosphatidylinositol transfer protein, beta; in intron #18 of Adenylate cyclase 3; and in exon #2 of Hypothetical gene supported by AK128346.

In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3′ of Replication factor C (activator 1) 3; in intron #2 of Ankyrin repeat domain 15; in exon #19 of Hypothetical protein FLJ12949; in exon #15 of Solute carrier family 43, member 1; 313,721 base pair 3′ of Thioredoxin-like 2; in exon #2 of Polymerase (RNA) II (DNA directed) polypeptide L, 7.6 kDa; in intron #10 of Syntaxin 5; 141,389 base pair 5′ of Leucine rich repeat containing 16; in intron #2 of Calcium channel, voltage-dependent, beta 4 subunit; 5,474 base pair 5′ of [NM_—001005522]; in intron #14 of G protein-coupled receptor kinase interactor 2; in intron #23 of Ankyrin 3, node of Ranvier (ankyrin G); 71,333 base pair 3′ of Gremlin 1, cysteine knot superfamily, homolog; 1,561 base pair of 3′ of Zinc finger protein 667; in exon #2 of Hypothetical gene supported by AK128346; in intron #11 of Transmembrane 9 superfamily member 2; in intron #1 of Potassium channel, subfamily K, member 1; in intron #2 of Chromodomain helicase DNA binding protein 2; 22,184 base pair 5′ of Microcephaly, primary autosomal recessive 1; in intron #4 of Chromosome 21 open reading frame 34; and in intron #2 of Dual specificity phosphatase 5.

In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3′ of Replication factor C (activator 1) 3, 38 kDa; 58,123 base pair 3′ of Tripartite motif-containing 61; in intron #3 of Citrate lyase beta like; in intron #2 of Ankyrin repeat domain 15; in intron #38 of Maltase-glucoamylase (alpha-glucosidase); and in intron #23 of Ankyrin 3, node of Ranvier (ankyrin G).

In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3′ of Replication factor C (activator 1) 3, 38 kDa; in intron #2 of Ankyrin repeat domain 15; in exon #19 of Hypothetical protein FLJ12949; in exon #15 of Solute carrier family 43, member 1; 313,721 base pair 3′ of Thioredoxin-like 2; in exon #2 of Polymerase (RNA) II (DNA directed) polypeptide L, 7.6 kDa; in intron #10 of Syntaxin 5; 141,389 base pair 5′ of Leucine rich repeat containing 16; in intron #2 of Calcium channel, voltage-dependent, beta 4 subunit; 5,474 base pair 5′ of [NM_—001005522]; in intron #14 of G protein-coupled receptor kinase interactor 2; in intron #2 of Ankyrin 3, node of Ranvier (ankyrin G); 71,333 base pair of 3′ Gremlin 1, cysteine knot superfamily; 1,561 base pair 3′ of Zinc finger protein 667; in exon #2 of Hypothetical gene supported by AK128346; in intron #11 of Transmembrane 9 superfamily member 2; in intron #1 of Potassium channel, subfamily K, member 1; in intron #2 of Chromodomain helicase DNA binding protein 2; in exon #8 of Chromosome 9 open reading frame 94; in intron #4 of Chromosome 21 open reading frame 34; and

in intron #2 of Dual specificity phosphatase 5.

In one embodiment, the Prostate Classification Set comprises target sequences derived from in intron #3 of Citrate lyase beta like; 210,560 base pair 5′ of Phosphodiesterase 4D; 189,722 base pair 5′ of Ectodysplasin A receptor; 3,510 base pair 3′ of DEP domain containing 6; in exon #6 of Basonuclin 2; in intron #1 of Chromosome 2 open reading frame 3; in intron #1 of FLJ25476 protein; in intron #10 of Staphylococcal nuclease and tudor domain containing 1; in exon #22 of Hermansky-Pudlak syndrome 5; and in exon #24 of Chromosome 12 open reading frame 30.

In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3′ of Replication factor C (activator 1) 3, 38 kDa; 58,123 base pair 3′ of Tripartite motif-containing 61; in intron #3 of Citrate lyase beta like; in intron #1 of Adaptor-related protein complex 1, gamma 2 subunit; in intron #2 of Kallikrein-related peptidase 2; 210,560 base pair 5′ of Phosphodiesterase 4D; 3,508 base pair 3′ of Cytochrome P450, family 4, subfamily F, polypeptide 11; 189,722 base pair 5′ of Ectodysplasin A receptor; in intron #2 of Phospholipase C, beta 1; in intron #10 of KIAA1244; in intron #2 of Paraoxonase 2; 11,235 base pair 3′ of Arachidonate 12-lipoxygenase, 12R type; in exon #22 of Cut-like 2; 143,098 base pair 5′ of Chemokine (C-X-C motif) ligand 12; in intron #6 of Rho guanine nucleotide exchange factor (GEF) 5; 15,057 base pair 5′ of Olfactory receptor, family 2, subfamily A, member 4; 6,025 base pair 3′ of Chromosome 19 open reading frame 42; in exon #2 of Hypothetical gene supported by AK128346; in exon #11 of Phosphoglucomutase 5; in exon #9 of Hyaluronan binding protein 4; in exon #8 of NECAP endocytosis associated 2; in intron #20 of Myeloid/lymphoid or mixed-lineage leukemia; 1,558 base pair 3′ of Signal transducer and activator of transcription; in intron #1 of Chromosome 2 open reading frame 3; in intron #1 of FLJ25476 protein; in intron #10 of Staphylococcal nuclease and tudor domain containing 1; 84,468 base pair 3′ of Transmembrane protein 18; in exon #22 of Hermansky-Pudlak syndrome 5; in exon #24 of Chromosome 12 open reading frame 30; 95,745 base pair of 3′ Splicing factor 3b, subunit 1; in exon #4 of Cofilin 2; in intron #1 of Heparan sulfate 6-O-sulfotransferase 3; in intron #1 of Enabled homolog; in intron #2 of Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase; in intron #8 of Solute carrier family 24, member 3; 32,382 base pair 3′ of Inositol 1,4,5-triphosphate receptor, type 1; in intron #9 of CAP-GLY domain containing linker protein 1; in exon #14 of Transglutaminase 4; in intron #4 of MOCO sulphurase C-terminal domain containing 2; 21,555 base pair 5′ of 4 hydroxyphenylpyruvate dioxygenase-like; and in exon #26 of R3H domain containing 1.

In one embodiment, the potential set of target sequences can be filtered for their expression levels using the multi-tissue expression data made publicly available by Affymetrix at (http://www.affymetrix.com/stipport/technical/sample_data/exon_array_data.affx) such that probes with, for example, elevated expression across numerous tissues (non-specific) or no expression in prostate tissue can be excluded.

Validation of Target Sequences

Following in silico selection of target sequences, each target sequence suitable for use in the Prostate Cancer Prognostic Set may be validated to confirm differential relative or normalized expression in recurrent prostate cancer or non-recurrent prostate cancer. Validation methods are known in the art and include hybridization techniques such as microarray analysis or Northern blotting using appropriate controls, and may include one or more additional steps, such as reverse transcription, transcription, PCR, RT-PCR and the like. The validation of the target sequences using these methods is well within the abilities of a worker skilled in the art.

Minimal Expression Signature

In one embodiment, individual Prostate Cancer Prognostic Sets provide for at least a determination of a minimal expression signature, capable of distinguishing recurrent from non-recurrent forms of prostate cancer. Means for determining the appropriate number of target sequences necessary to obtain a minimal expression signature are known in the art and include the Nearest Shrunken Centroids (NSC) method.

In this method (see US 20070031873), a standardized centroid is computed for each class. This is the average gene expression for each gene in each class divided by the within-class standard deviation for that gene. Nearest centroid classification takes the gene expression profile of a new sample, and compares it to each of these class centroids. The class whose centroid that it is closest to, in squared distance, is the predicted class for that new sample. Nearest shrunken centroid classification “shrinks” each of the class centroids toward the overall centroid for all classes by an amount called the threshold. This shrinkage consists of moving the centroid towards zero by threshold, setting it equal to zero if it hits zero. For example if threshold was 2.0, a centroid of 3.2 would be shrunk to 1.2, a centroid of −3.4 would be shrunk to −1.4, and a centroid of 1.2 would be shrunk to zero. After shrinking the centroids, the new sample is classified by the usual nearest centroid rule, but using the shrunken class centroids. This shrinkage can make the classifier more accurate by reducing the effect of noisy genes and provides an automatic gene selection. In particular, if a gene is shrunk to zero for all classes, then it is eliminated from the prediction rule. Alternatively, it may be set to zero for all classes except one, and it can be learned that the high or low expression for that gene characterizes that class. The user decides on the value to use for threshold. Typically one examines a number of different choices. To guide in this choice, PAM does K-fold cross-validation for a range of threshold values. The samples are divided up at random into K roughly equally sized parts. For each part in turn, the classifier is built on the other K−1 parts then tested on the remaining part. This is done for a range of threshold values, and the cross-validated misclassification error rate is reported for each threshold value. Typically, the user would choose the threshold value giving the minimum cross-validated misclassification error rate.

Alternatively, minimal expression signatures can be established through the use of optimization algorithms such as the mean variance algorithm widely used in establishing stock portfolios. This method is described in detail in US patent publication number 20030194734. Essentially, the method calls for the establishment of a set of inputs (stocks in financial applications, expression as measured by intensity here) that will optimize the return (e.g., signal that is generated) one receives for using it while minimizing the variability of the return. In other words, the method calls for the establishment of a set of inputs (e.g., expression as measured by intensity) that will optimize the signal while minimizing variability. Many commercial software programs are available to conduct such operations. “Wagner Associates Mean-Variance Optimization Application,” referred to as “Wagner Software” throughout this specification, is preferred. This software uses functions from the “Wagner Associates Mean-Variance Optimization Library” to determine an efficient frontier and optimal portfolios in the Markowitz sense is preferred. Use of this type of software requires that microarray data be transformed so that it can be treated as an input in the way stock return and risk measurements are used when the software is used for its intended financial analysis purposes.

The process of selecting a minimal expression signature can also include the application of heuristic rules. Preferably, such rules are formulated based on biology and an understanding of the technology used to produce clinical results. More preferably, they are applied to output from the optimization method. For example, the mean variance method of portfolio selection can be applied to microarray data for a number of genes differentially expressed in subjects with cancer. Output from the method would be an optimized set of genes that could include some genes that are expressed in peripheral blood as well as in diseased tissue.

Other heuristic rules can be applied that are not necessarily related to the biology in question. For example, one can apply a rule that only a prescribed percentage of the portfolio can be represented by a particular gene or group of genes. Commercially available software such as the Wagner Software readily accommodates these types of heuristics. This can be useful, for example, when factors other than accuracy and precision (e.g., anticipated licensing fees) have an impact on the desirability of including one or more genes.

In one embodiment, the Prostate Cancer Prognostic Set for obtaining a minimal expression signature comprises at least one, two, three, four, five, six, eight, 10, 15, 20, 25 or more of target sequences shown to have a positive correlation with non-recurrent prostate disease, for example those depicted in SEQ ID NOs:1-913 or a subset thereof. In another embodiment, the Prostate Cancer Prognostic Set for obtaining a minimal expression signature comprises at least one, two, three, four, five, six, eight, 10, 15, 20, 25 or more of those target sequences shown to have a positive correlation with recurrent prostate cancer, for example those depicted in of SEQ ID NOs: 914-2114, or a subset thereof. In yet another embodiment, the Prostate Cancer Prognostic Set for obtaining a minimal expression signature comprises at least one, two, three, four, five, six, eight, 10, 15, 20, 25 or more of target sequences shown to have a correlation with non-recurrent or recurrent prostate cancer, for example those depicted in SEQ ID NOs:1-2114 or a subset thereof.

In some embodiments, the Prostate Cancer Prognostic Set comprises target sequences for detecting expression products of SEQ IDs:1-2114. In some embodiments, the Prostate Cancer Prognostic Set comprises probes for detecting expression levels of sequences exhibiting positive and negative correlation with a disease status of interest are employed. For example, a combination target sequences useful in these methods were found to include those encoding RNAs corresponding to SEQ ID NOs: 1-913 (found at increased expression in prostate cancer samples from NED patients) and/or corresponding to SEQ ID NOs: 914-2114 (found at increased expression levels in prostate cancer samples from SYS patients), where intermediate levels of certain target sequences (Table 7) are observed in prostate cancer samples from PSA patients with biochemical recurrence, where the RNA expression levels are indicative of a disease state or outcome. Subgroups of these target sequences, as well as individual target sequences, have been found useful in such methods.

In some embodiments, an RNA signature corresponding to SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21 915-917, 920, 922, 928, 929, 931, 935 and 936 (the 21-RNA′ signature) and/or SEQ ID NOs: 1-11, 914-920 (the ‘18-RNA’ signature) and/or SEQ ID NOs: 1-4, 914,915) (the ‘6-RNA’ signature) and/or SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 931, 935 and 936 (the ‘20-RNA’ signature) and/or SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014 and 1022 (the ‘10-RNA’ signature) and/or SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402 and 1425 (the ‘41-RNA’ signature) are formulated into a linear combination of their respective expression values for each patient generating a patient outcome predictor (‘POP’) score and indicative of the disease status of the patient after prostatectomy.

Exemplary subsets and combinations of interest also include at least five, six, 10, 15, 18, 20, 23, 25, 27, 30, 35, 40, 45, 50, 55, 60, 70, 80, 90, 100, 125, 150, 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 750, 1000, 1200, 1400, 1600, 1800, 2000, or all 2114 target sequences in Table 4; at least five, six, 10, 15, 18, 20, 23, 25, 27, 30, 35, 40, 45, 50, 55, 60, 70, 80, 90, 100, 125, 150, 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, or all 526 target sequences in Table 7; SEQ ID NOs:1, 4, 915, 6, 916, 9, 917, 920, 922, 14, 15, 16, 928, 929, 18, 19, 931, 20, 21, 935, 936, or combinations thereof; SEQ ID NOs:1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 914, 915, 916, 917, 918, 919, 920, or combinations thereof; SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 931, 935, 936 or combinations thereof; SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014, 1022 or combinations thereof; SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402, 1425 or combinations thereof; at least one, two, three, four, five or six of SEQ ID NOs:1, 4, 6, 9, 14, 15, 16, 18, 19, 20, and 21 and at least one, two, three, four, five or six of SEQ ID NOs:915, 916, 917, 920, 922, 928, 929, 931, 935, and 936; and at least one, two, three, four, five or six of SEQ ID NOs:1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 at least one, two, three, four, five or six of at least one, two, three, four, five or six of SEQ ID NOs:914, 915, 916, 917, 918, 919, and 920 and at least one, two, three, four, five or six of SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 931, 935, 936; and at least one, two, three, four, five or six of SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014, 1022; and at least one, two, three, four, five or six of SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402, 1425.

Exemplary subsets of interest include those described herein, including in the examples. Exemplary combinations of interest include those utilizing one or more of the sequences listed in Tables 5, 7, 8, 9 or 10. Of particular interest are those combinations utilizing at least one sequence exhibiting positive correlation with the trait of interest, as well as those combinations utilizing at least one sequence exhibiting negative correlation with the trait of interest. Also of interest are those combinations utilizing at least two, at least three, at least four, at least five or at least six of those sequences exhibiting such a positive correlation, in combination with at least two, at least three, at least four, at least five, or at least six of those sequences exhibiting such a negative correlation. Exemplary combinations include those utilizing at least one, two, three, four, five or six of the target sequences depicted in Tables 5 and 6.

In some embodiments, increased relative expression of one or more of SEQ IDs:1-913, decreased relative expression of one or more of SEQ ID NOs:914-2114 or a combination of any thereof is indicative/predictive of the patient exhibiting no evidence of disease for at least seven years or more after surgery. In some embodiments, increased relative expression of SEQ IDs:914-2114, decreased relative expression of one or more of SEQ ID NOs:1-913 or a combination of any thereof is indicative/predictive of the patient exhibiting systemic prostate cancer. Increased or decreased expression of target sequences represented in these sequence listings, or of the target sequences described in the examples, may be utilized in the methods of the invention.

The Prostate Cancer Prognostic Set can optionally include one or more target sequences specifically derived from the transcripts of one or more housekeeping genes and/or one or more internal control target sequences and/or one or more negative control target sequences. In one embodiment, these target sequences can, for example, be used to normalize expression data. Housekeeping genes from which target sequences for inclusion in a Prostate Cancer Prognostic Set can be derived from are known in the art and include those genes in which are expressed at a constant level in normal and prostate cancer tissue.

The target sequences described herein may be used alone or in combination with each other or with other known or later identified disease markers.

Prostate Cancer Prognostic Probes/Primers

The system of the present invention provides for combinations of polynucleotide probes that are capable of detecting the target sequences of the Prostate Cancer Prognostic Sets. Individual polynucleotide probes comprise a nucleotide sequence derived from the nucleotide sequence of the target sequences or complementary sequences thereof. The nucleotide sequence of the polynucleotide probe is designed such that it corresponds to, or is complementary to the target sequences. The polynucleotide probe can specifically hybridize under either stringent or lowered stringency hybridization conditions to a region of the target sequences, to the complement thereof, or to a nucleic acid sequence (such as a cDNA) derived therefrom.

The selection of the polynucleotide probe sequences and determination of their uniqueness may be carried out in silico using techniques known in the art, for example, based on a BLASTN search of the polynucleotide sequence in question against gene sequence databases, such as the Human Genome Sequence, UniGene, dbEST or the non-redundant database at NCBI. In one embodiment of the invention, the polynucleotide probe is complementary to a region of a target mRNA derived from a target sequence in the Prostate Cancer Prognostic Set. Computer programs can also be employed to select probe sequences that will not cross hybridize or will not hybridize non-specifically.

One skilled in the art will understand that the nucleotide sequence of the polynucleotide probe need not be identical to its target sequence in order to specifically hybridize thereto. The polynucleotide probes of the present invention, therefore, comprise a nucleotide sequence that is at least about 75% identical to a region of the target gene or mRNA. In another embodiment, the nucleotide sequence of the polynucleotide probe is at least about 90% identical a region of the target gene or mRNA. In a further embodiment, the nucleotide sequence of the polynucleotide probe is at least about 95% identical to a region of the target gene or mRNA. Methods of determining sequence identity are known in the art and can be determined, for example, by using the BLASTN program of the University of Wisconsin Computer Group (GCG) software or provided on the NCBI website. The nucleotide sequence of the polynucleotide probes of the present invention may exhibit variability by differing (e.g. by nucleotide substitution, including transition or transversion) at one, two, three, four or more nucleotides from the sequence of the target gene.

Other criteria known in the art may be employed in the design of the polynucleotide probes of the present invention. For example, the probes can be designed to have <50% G content and/or between about 25% and about 70% G+C content. Strategies to optimize probe hybridization to the target nucleic acid sequence can also be included in the process of probe selection. Hybridization under particular pH, salt, and temperature conditions can be optimized by taking into account melting temperatures and by using empirical rules that correlate with desired hybridization behaviours. Computer models may be used for predicting the intensity and concentration-dependence of probe hybridization.

As is known in the art, in order to represent a unique sequence in the human genome, a probe should be at least 15 nucleotides in length. Accordingly, the polynucleotide probes of the present invention range in length from about 15 nucleotides to the full length of the target sequence or target mRNA. In one embodiment of the invention, the polynucleotide probes are at least about 15 nucleotides in length. In another embodiment, the polynucleotide probes are at least about 20 nucleotides in length. In a further embodiment, the polynucleotide probes are at least about 25 nucleotides in length. In another embodiment, the polynucleotide probes are between about 15 nucleotides and about 500 nucleotides in length. In other embodiments, the polynucleotide probes are between about 15 nucleotides and about 450 nucleotides, about 15 nucleotides and about 400 nucleotides, about 15 nucleotides and about 350 nucleotides, about 15 nucleotides and about 300 nucleotides in length.

The polynucleotide probes of a Prostate Cancer Prognostic Set can comprise RNA, DNA, RNA or DNA mimetics, or combinations thereof, and can be single-stranded or double-stranded. Thus the polynucleotide probes can be composed of naturally-occurring nucleobases, sugars and covalent internucleoside (backbone) linkages as well as polynucleotide probes having non-naturally-occurring portions which function similarly. Such modified or substituted polynucleotide probes may provide desirable properties such as, for example, enhanced affinity for a target gene and increased stability.

The system of the present invention further provides for primers and primer pairs capable of amplifying target sequences defined by the Prostate Cancer Prognostic Set, or fragments or subsequences or complements thereof. The nucleotide sequences of the Prostate Cancer Prognostic set may be provided in computer-readable media for in silico applications and as a basis for the design of appropriate primers for amplification of one or more target sequences of the Prostate Cancer Prognostic Set.

Primers based on the nucleotide sequences of target sequences can be designed for use in amplification of the target sequences. For use in amplification reactions such as PCR, a pair of primers will be used. The exact composition of the primer sequences is not critical to the invention, but for most applications the primers will hybridize to specific sequences of the Prostate Cancer Prognostic Set under stringent conditions, particularly under conditions of high stringency, as known in the art. The pairs of primers are usually chosen so as to generate an amplification product of at least about 50 nucleotides, more usually at least about 100 nucleotides. Algorithms for the selection of primer sequences are generally known, and are available in commercial software packages. These primers may be used in standard quantitative or qualitative PCR-based assays to assess transcript expression levels of RNAs defined by the Prostate Cancer Prognostic Set. Alternatively, these primers may be used in combination with probes, such as molecular beacons in amplifications using real-time PCR.

In one embodiment, the primers or primer pairs, when used in an amplification reaction, specifically amplify at least a portion of a nucleic acid depicted in one of SEQ ID NOs: 1-2114 (or subgroups thereof as set forth herein), an RNA form thereof, or a complement to either thereof.

As is known in the art, a nucleoside is a base-sugar combination and a nucleotide is a nucleoside that further includes a phosphate group covalently linked to the sugar portion of the nucleoside. In forming oligonucleotides, the phosphate groups covalently link adjacent nucleosides to one another to form a linear polymeric compound, with the normal linkage or backbone of RNA and DNA being a 3′ to 5′ phosphodiester linkage. Specific examples of polynucleotide probes or primers useful in this invention include oligonucleotides containing modified backbones or non-natural internucleoside linkages. As defined in this specification, oligonucleotides having modified backbones include both those that retain a phosphorus atom in the backbone and those that lack a phosphorus atom in the backbone. For the purposes of the present invention, and as sometimes referenced in the art, modified oligonucleotides that do not have a phosphorus atom in their internucleoside backbone can also be considered to be oligonucleotides.

Exemplary polynucleotide probes or primers having modified oligonucleotide backbones include, for example, those with one or more modified internucleotide linkages that are phosphorothioates, chiral phosphorothioates, phosphorodithioates, phosphotriesters, aminoalkylphosphotriesters, methyl and other alkyl phosphonates including 3′-alkylene phosphonates and chiral phosphonates, phosphinates, phosphoramidates including 3′ amino phosphoramidate and aminoalkylphosphoramidates, thionophosphoramidates, thionoalkyl-phosphonates, thionoalkylphosphotriesters, and boranophosphates having normal 3′-5′ linkages, 2′-5′ linked analogs of these, and those having inverted polarity wherein the adjacent pairs of nucleoside units are linked 3′-5′ to 5′-3′ or 2′-5′ to 5′-2′. Various salts, mixed salts and free acid forms are also included.

Exemplary modified oligonucleotide backbones that do not include a phosphorus atom are formed by short chain alkyl or cycloalkyl internucleoside linkages, mixed heteroatom and alkyl or cycloalkyl internucleoside linkages, or one or more short chain heteroatomic or heterocyclic internucleoside linkages. Such backbones include morpholino linkages (formed in part from the sugar portion of a nucleoside); siloxane backbones; sulfide, sulfoxide and sulphone backbones; formacetyl and thioformacetyl backbones; methylene formacetyl and thioformacetyl backbones; alkene containing backbones; sulphamate backbones; methyleneimino and methylenehydrazino backbones; sulphonate and sulfonamide backbones; amide backbones; and others having mixed N, O, S and CH₂ component parts.

The present invention also contemplates oligonucleotide mimetics in which both the sugar and the internucleoside linkage of the nucleotide units are replaced with novel groups. The base units are maintained for hybridization with an appropriate nucleic acid target compound. An example of such an oligonucleotide mimetic, which has been shown to have excellent hybridization properties, is a peptide nucleic acid (PNA) [Nielsen et al., Science, 254:1497-1500 (1991)]. In PNA compounds, the sugar-backbone of an oligonucleotide is replaced with an amide containing backbone, in particular an aminoethylglycine backbone. The nucleobases are retained and are bound directly or indirectly to aza-nitrogen atoms of the amide portion of the backbone. The present invention also contemplates polynucleotide probes or primers comprising “locked nucleic acids” (LNAs), which are novel conformationally restricted oligonucleotide analogues containing a methylene bridge that connects the 2′-O of ribose with the 4′-C (see, Singh et al., Chem. Commun., 1998, 4:455-456). LNA and LNA analogues display very high duplex thermal stabilities with complementary DNA and RNA, stability towards 3′-exonuclease degradation, and good solubility properties. Synthesis of the LNA analogues of adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil, their oligomerization, and nucleic acid recognition properties have been described (see Koshkin et al., Tetrahedron, 1998, 54:3607-3630). Studies of mis-matched sequences show that LNA obey the Watson-Crick base pairing rules with generally improved selectivity compared to the corresponding unmodified reference strands.

LNAs form duplexes with complementary DNA or RNA or with complementary LNA, with high thermal affinities. The universality of LNA-mediated hybridization has been emphasized by the formation of exceedingly stable LNA:LNA duplexes (Koshkin et al., J. Am. Chem. Soc., 1998, 120:13252-13253). LNA:LNA hybridization was shown to be the most thermally stable nucleic acid type duplex system, and the RNA-mimicking character of LNA was established at the duplex level. Introduction of three LNA monomers (T or A) resulted in significantly increased melting points toward DNA complements.

Synthesis of 2′-amino-LNA (Singh et al., J. Org. Chem., 1998, 63, 10035-10039) and 2′-methylamino-LNA has been described and thermal stability of their duplexes with complementary RNA and DNA strands reported. Preparation of phosphorothioate-LNA and 2′-thio-LNA have also been described (Kumar et al., Bioorg. Med. Chem. Lett., 1998, 8:2219-2222).

Modified polynucleotide probes or primers may also contain one or more substituted sugar moieties. For example, oligonucleotides may comprise sugars with one of the following substituents at the 2′ position: OH; F; O—, S—, or N-alkyl; O—, S—, or N-alkenyl; O—, S— or N-alkynyl; or O-alkyl-O-alkyl, wherein the alkyl, alkenyl and alkynyl may be substituted or unsubstituted C₁ to C₁₀ alkyl or C₂ to C₁₀ alkenyl and alkynyl. Examples of such groups are: O[(CH₂)_n O]_m CH₃, O(CH₂)_n OCH₃, O(CH₂)_n NH₂, O(CH₂)_n CH₃, O(CH₂)_n ONH₂, and O(CH₂)_n ON[(CH₂)_n CH₃)]₂, where n and m are from 1 to about 10. Alternatively, the oligonucleotides may comprise one of the following substituents at the 2′ position: C₁ to C₁₀ lower alkyl, substituted lower alkyl, alkaryl, aralkyl, O-alkaryl or O-aralkyl, SH, SCH₃, OCN, Cl, Br, CN, CF₃, OCF₃, SOCH₃, SO₂ CH₃, ONO₂, NO₂, N₃, NH₂, heterocycloalkyl, heterocycloalkaryl, aminoalkylamino, polyalkylamino, substituted silyl, an RNA cleaving group, a reporter group, an intercalator, a group for improving the pharmacokinetic properties of an oligonucleotide, or a group for improving the pharmacodynamic properties of an oligonucleotide, and other substituents having similar properties. Specific examples include 2′-methoxyethoxy (2′-O—CH₂ CH₂ OCH₃, also known as 2′-O-(2-methoxyethyl) or 2′-MOE) [Martin et al., Helv. Chim. Acta, 78:486-504 (1995)], 2′-dimethylaminooxyethoxy (O(CH₂)₂ ON(CH₃)₂ group, also known as 2′-DMAOE), 2′-methoxy (2′-O—CH₃), 2′-aminopropoxy (2′-OCH₂ CH₂ CH₂ NH₂) and 2′-fluoro (2′-F).

Similar modifications may also be made at other positions on the polynucleotide probes or primers, particularly the 3′ position of the sugar on the 3′ terminal nucleotide or in 2′-5′ linked oligonucleotides and the 5′ position of 5′ terminal nucleotide. Polynucleotide probes or primers may also have sugar mimetics such as cyclobutyl moieties in place of the pentofuranosyl sugar.

Polynucleotide probes or primers may also include modifications or substitutions to the nucleobase. As used herein, “unmodified” or “natural” nucleobases include the purine bases adenine (A) and guanine (G), and the pyrimidine bases thymine (T), cytosine (C) and uracil (U). Modified nucleobases include other synthetic and natural nucleobases such as 5-methylcytosine (5-me-C), 5-hydroxymethyl cytosine, xanthine, hypoxanthine, 2-aminoadenine, 6-methyl and other alkyl derivatives of adenine and guanine, 2-propyl and other alkyl derivatives of adenine and guanine, 2-thiouracil, 2-thiothymine and 2-thiocytosine, 5-halouracil and cytosine, 5-propynyl uracil and cytosine, 6-azo uracil, cytosine and thymine, 5-uracil (pseudouracil), 4-thiouracil, 8-halo, 8-amino, 8-thiol, 8-thioalkyl, 8-hydroxyl and other 8-substituted adenines and guanines, 5-halo particularly 5-bromo, 5-trifluoromethyl and other 5-substituted uracils and cytosines, 7-methylguanine and 7-methyladenine, 8-azaguanine and 8-azaadenine, 7-deazaguanine and 7-deazaadenine and 3-deazaguanine and 3-deazaadenine. Further nucleobases include those disclosed in U.S. Pat. No. 3,687,808; The Concise Encyclopedia Of Polymer Science And Engineering, (1990) pp 858-859, Kroschwitz, J. I., ed. John Wiley & Sons; Englisch et al., Angewandte Chemie, Int. Ed., 30:613 (1991); and Sanghvi, Y. S., (1993) Antisense Research and Applications, pp 289-302, Crooke, S. T. and Lebleu, B., ed., CRC Press. Certain of these nucleobases are particularly useful for increasing the binding affinity of the polynucleotide probes of the invention. These include 5-substituted pyrimidines, 6-azapyrimidines and N-2, N-6 and O-6 substituted purines, including 2-aminopropyladenine, 5-propynyluracil and 5-propynylcytosine. 5-methylcytosine substitutions have been shown to increase nucleic acid duplex stability by 0.6-1.2° C. [Sanghvi, Y. S., (1993) Antisense Research and Applications, pp 276-278, Crooke, S. T. and Lebleu, B., ed., CRC Press, Boca Raton].

One skilled in the art will recognize that it is not necessary for all positions in a given polynucleotide probe or primer to be uniformly modified. The present invention, therefore, contemplates the incorporation of more than one of the aforementioned modifications into a single polynucleotide probe or even at a single nucleoside within the probe or primer.

One skilled in the art will also appreciate that the nucleotide sequence of the entire length of the polynucleotide probe or primer does not need to be derived from the target sequence. Thus, for example, the polynucleotide probe may comprise nucleotide sequences at the 5′ and/or 3′ termini that are not derived from the target sequences. Nucleotide sequences which are not derived from the nucleotide sequence of the target sequence may provide additional functionality to the polynucleotide probe. For example, they may provide a restriction enzyme recognition sequence or a “tag” that facilitates detection, isolation, purification or immobilisation onto a solid support. Alternatively, the additional nucleotides may provide a self-complementary sequence that allows the primer/probe to adopt a hairpin configuration. Such configurations are necessary for certain probes, for example, molecular beacon and Scorpion probes, which can be used in solution hybridization techniques.

The polynucleotide probes or primers can incorporate moieties useful in detection, isolation, purification, or immobilisation, if desired. Such moieties are well-known in the art (see, for example, Ausubel et al., (1997 & updates) Current Protocols in Molecular Biology, Wiley & Sons, New York) and are chosen such that the ability of the probe to hybridize with its target sequence is not affected.

Examples of suitable moieties are detectable labels, such as radioisotopes, fluorophores, chemiluminophores, enzymes, colloidal particles, and fluorescent microparticles, as well as antigens, antibodies, haptens, avidin/streptavidin, biotin, haptens, enzyme cofactors/substrates, enzymes, and the like.

A label can optionally be attached to or incorporated into a probe or primer polynucleotide to allow detection and/or quantitation of a target polynucleotide representing the target sequence of interest. The target polynucleotide may be the expressed target sequence RNA itself, a cDNA copy thereof, or an amplification product derived therefrom, and may be the positive or negative strand, so long as it can be specifically detected in the assay being used. Similarly, an antibody may be labeled.

In certain multiplex formats, labels used for detecting different targets may be distinguishable. The label can be attached directly (e.g., via covalent linkage) or indirectly, e.g., via a bridging molecule or series of molecules (e.g., a molecule or complex that can bind to an assay component, or via members of a binding pair that can be incorporated into assay components, e.g. biotin-avidin or streptavidin). Many labels are commercially available in activated forms which can readily be used for such conjugation (for example through amine acylation), or labels may be attached through known or determinable conjugation schemes, many of which are known in the art.

Labels useful in the invention described herein include any substance which can be detected when bound to or incorporated into the biomolecule of interest. Any effective detection method can be used, including optical, spectroscopic, electrical, piezoelectrical, magnetic, Raman scattering, surface plasmon resonance, colorimetric, calorimetric, etc. A label is typically selected from a chromophore, a lumiphore, a fluorophore, one member of a quenching system, a chromogen, a hapten, an antigen, a magnetic particle, a material exhibiting nonlinear optics, a semiconductor nanocrystal, a metal nanoparticle, an enzyme, an antibody or binding portion or equivalent thereof, an aptamer, and one member of a binding pair, and combinations thereof. Quenching schemes may be used, wherein a quencher and a fluorophore as members of a quenching pair may be used on a probe, such that a change in optical parameters occurs upon binding to the target introduce or quench the signal from the fluorophore. One example of such a system is a molecular beacon. Suitable quencher/fluorophore systems are known in the art. The label may be bound through a variety of intermediate linkages. For example, a polynucleotide may comprise a biotin-binding species, and an optically detectable label may be conjugated to biotin and then bound to the labeled polynucleotide. Similarly, a polynucleotide sensor may comprise an immunological species such as an antibody or fragment, and a secondary antibody containing an optically detectable label may be added.

Chromophores useful in the methods described herein include any substance which can absorb energy and emit light. For multiplexed assays, a plurality of different signaling chromophores can be used with detectably different emission spectra. The chromophore can be a lumophore or a fluorophore. Typical fluorophores include fluorescent dyes, semiconductor nanocrystals, lanthanide chelates, polynucleotide-specific dyes and green fluorescent protein.

Coding schemes may optionally be used, comprising encoded particles and/or encoded tags associated with different polynucleotides of the invention. A variety of different coding schemes are known in the art, including fluorophores, including SCNCs, deposited metals, and RF tags.

Polynucleotides from the described target sequences may be employed as probes for detecting target sequences expression, for ligation amplification schemes, or may be used as primers for amplification schemes of all or a portion of a target sequences. When amplified, either strand produced by amplification may be provided in purified and/or isolated form.

In one embodiment, polynucleotides of the invention include a nucleic acid depicted in (a) any one of SEQ ID NOs: 1-2114, or a subgroup thereof as set forth herein; (b) an RNA form of any one of the nucleic acids depicted in SEQ ID NOs: 1-2114, or a subgroup thereof as set forth herein; (c) a peptide nucleic acid form of any of the nucleic acids depicted in SEQ ID NOs: 1-2114, or a subgroup thereof as set forth herein; (d) a nucleic acid comprising at least 20 consecutive bases of any of (a-c); (e) a nucleic acid comprising at least 25 bases having at least 90% sequenced identity to any of (a-c); and (f) a complement to any of (a-e).

Complements may take any polymeric form capable of base pairing to the species recited in (a)-(e), including nucleic acid such as RNA or DNA, or may be a neutral polymer such as a peptide nucleic acid. Polynucleotides of the invention can be selected from the subsets of the recited nucleic acids described herein, as well as their complements.

In some embodiments, polynucleotides of the invention comprise at least 20 consecutive bases as depicted in SEQ ID NOs:1-2114, or a complement thereto. The polynucleotides may comprise at least 21, 22, 23, 24, 25, 27, 30, 32, 35 or more consecutive bases as depicted in SEQ ID NOs:1-2114, as applicable.

In some embodiments, the nucleic acid in (a) can be selected from those in Table 3, and from SEQ ID NOs:1, 4, 915, 6, 916, 9, 917, 920, 922, 14, 15, 16, 928, 929, 18, 19, 931, 20, 21, 935, and 936; or from SEQ ID NOs:1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 914, 915, 916, 917, 918, 919, and 920; or from SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 931, 935 and 936; or from SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014 and 1022; or from SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402 and 1425.

The polynucleotides may be provided in a variety of formats, including as solids, in solution, or in an array. The polynucleotides may optionally comprise one or more labels, which may be chemically and/or enzymatically incorporated into the polynucleotide.

In one embodiment, solutions comprising polynucleotide and a solvent are also provided. In some embodiments, the solvent may be water or may be predominantly aqueous. In some embodiments, the solution may comprise at least two, three, four, five, six, seven, eight, nine, ten, twelve, fifteen, seventeen, twenty or more different polynucleotides, including primers and primer pairs, of the invention. Additional substances may be included in the solution, alone or in combination, including one or more labels, additional solvents, buffers, biomolecules, polynucleotides, and one or more enzymes useful for performing methods described herein, including polymerases and ligases. The solution may further comprise a primer or primer pair capable of amplifying a polynucleotide of the invention present in the solution.

In some embodiments, one or more polynucleotides provided herein can be provided on a substrate. The substrate can comprise a wide range of material, either biological, nonbiological, organic, inorganic, or a combination of any of these. For example, the substrate may be a polymerized Langmuir Blodgett film, functionalized glass, Si, Ge, GaAs, GaP, SiO₂, SiN₄, modified silicon, or any one of a wide variety of gels or polymers such as (poly)tetrafluoroethylene, (poly)vinylidenedifluoride, polystyrene, cross-linked polystyrene, polyacrylic, polylactic acid, polyglycolic acid, poly(lactide coglycolide), polyanhydrides, poly(methyl methacrylate), poly(ethylene-co-vinyl acetate), polysiloxanes, polymeric silica, latexes, dextran polymers, epoxies, polycarbonates, or combinations thereof. Conducting polymers and photoconductive materials can be used.

Substrates can be planar crystalline substrates such as silica based substrates (e.g. glass, quartz, or the like), or crystalline substrates used in, e.g., the semiconductor and microprocessor industries, such as silicon, gallium arsenide, indium doped GaN and the like, and includes semiconductor nanocrystals.

The substrate can take the form of an array, a photodiode, an optoelectronic sensor such as an optoelectronic semiconductor chip or optoelectronic thin-film semiconductor, or a biochip. The location(s) of probe(s) on the substrate can be addressable; this can be done in highly dense formats, and the location(s) can be microaddressable or nanoaddressable.

Silica aerogels can also be used as substrates, and can be prepared by methods known in the art. Aerogel substrates may be used as free standing substrates or as a surface coating for another substrate material.

The substrate can take any form and typically is a plate, slide, bead, pellet, disk, particle, microparticle, nanoparticle, strand, precipitate, optionally porous gel, sheets, tube, sphere, container, capillary, pad, slice, film, chip, multiwell plate or dish, optical fiber, etc. The substrate can be any form that is rigid or semi-rigid. The substrate may contain raised or depressed regions on which an assay component is located. The surface of the substrate can be etched using known techniques to provide for desired surface features, for example trenches, v-grooves, mesa structures, or the like.

Surfaces on the substrate can be composed of the same material as the substrate or can be made from a different material, and can be coupled to the substrate by chemical or physical means. Such coupled surfaces may be composed of any of a wide variety of materials, for example, polymers, plastics, resins, polysaccharides, silica or silica-based materials, carbon, metals, inorganic glasses, membranes, or any of the above-listed substrate materials. The surface can be optically transparent and can have surface Si—OH functionalities, such as those found on silica surfaces.

The substrate and/or its optional surface can be chosen to provide appropriate characteristics for the synthetic and/or detection methods used. The substrate and/or surface can be transparent to allow the exposure of the substrate by light applied from multiple directions. The substrate and/or surface may be provided with reflective “mirror” structures to increase the recovery of light.

The substrate and/or its surface is generally resistant to, or is treated to resist, the conditions to which it is to be exposed in use, and can be optionally treated to remove any resistant material after exposure to such conditions.

The substrate or a region thereof may be encoded so that the identity of the sensor located in the substrate or region being queried may be determined Any suitable coding scheme can be used, for example optical codes, RFID tags, magnetic codes, physical codes, fluorescent codes, and combinations of codes.

Preparation of Probes and Primers

The polynucleotide probes or primers of the present invention can be prepared by conventional techniques well-known to those skilled in the art. For example, the polynucleotide probes can be prepared using solid-phase synthesis using commercially available equipment. As is well-known in the art, modified oligonucleotides can also be readily prepared by similar methods. The polynucleotide probes can also be synthesized directly on a solid support according to methods standard in the art. This method of synthesizing polynucleotides is particularly useful when the polynucleotide probes are part of a nucleic acid array.

Polynucleotide probes or primers can be fabricated on or attached to the substrate by any suitable method, for example the methods described in U.S. Pat. No. 5,143,854, PCT Publ. No. WO 92/10092, U.S. patent application Ser. No. 07/624,120, filed Dec. 6, 1990 (now abandoned), Fodor et al., Science, 251: 767-777 (1991), and PCT Publ. No. WO 90/15070). Techniques for the synthesis of these arrays using mechanical synthesis strategies are described in, e.g., PCT Publication No. WO 93/09668 and U.S. Pat. No. 5,384,261. Still further techniques include bead based techniques such as those described in PCT Appl. No. PCT/US93/04145 and pin based methods such as those described in U.S. Pat. No. 5,288,514. Additional flow channel or spotting methods applicable to attachment of sensor polynucleotides to a substrate are described in U.S. patent application Ser. No. 07/980,523, filed Nov. 20, 1992, and U.S. Pat. No. 5,384,261.

Alternatively, the polynucleotide probes of the present invention can be prepared by enzymatic digestion of the naturally occurring target gene, or mRNA or cDNA derived therefrom, by methods known in the art.

Prostate Cancer Prognostic Methods

The present invention further provides methods for characterizing prostate cancer sample for recurrence risk. The methods use the Prostate Cancer Prognostic Sets, probes and primers described herein to provide expression signatures or profiles from a test sample derived from a subject having or suspected of having prostate cancer. In some embodiments, such methods involve contacting a test sample with Prostate Cancer Prognostic probes (either in solution or immobilized) under conditions that permit hybridization of the probe(s) to any target nucleic acid(s) present in the test sample and then detecting any probe:target duplexes formed as an indication of the presence of the target nucleic acid in the sample. Expression patterns thus determined are then compared to one or more reference profiles or signatures. Optionally, the expression pattern can be normalized. The methods use the Prostate Cancer Prognostic Sets, probes and primers described herein to provide expression signatures or profiles from a test sample derived from a subject to classify the prostate cancer as recurrent or non-recurrent.

In some embodiments, such methods involve the specific amplification of target sequences nucleic acid(s) present in the test sample using methods known in the art to generate an expression profile or signature which is then compared to a reference profile or signature.

In some embodiments, the invention further provides for prognosing patient outcome, predicting likelihood of recurrence after prostatectomy and/or for designating treatment modalities.

In one embodiment, the methods generate expression profiles or signatures detailing the expression of the 2114 target sequences having altered relative expression with different prostate cancer outcomes. In one embodiment, the methods generate expression profiles or signatures detailing the expression of the subsets of these target sequences having 526 or 18 target sequences as described in the examples.

In some embodiments, increased relative expression of one or more of SEQ IDs:1-913, decreased relative expression of one or more of SEQ ID NOs:914-2114 or a combination of any thereof is indicative of a non-recurrent form of prostate cancer and may be predictive a NED clinical outcome after surgery. In some embodiments, increased relative expression of SEQ IDs:914-2114, decreased relative expression of one or more of SEQ ID NOs:1-913 or a combination of any thereof is indicative of a recurrent form of prostate cancer and may be predictive of a SYS clinical outcome after surgery. Increased or decreased expression of target sequences represented in these sequence listings, or of the target sequences described in the examples, may be utilized in the methods of the invention.

In one embodiment, intermediate levels of expression of one or more target sequences depicted in Table 7 indicate a probability of future biochemical recurrence.

In some embodiments, the methods detect combinations of expression levels of sequences exhibiting positive and negative correlation with a disease status. In one embodiment, the methods detect a minimal expression signature.

Any method of detecting and/or quantitating the expression of the encoded target sequences can in principle be used in the invention. Such methods can include Northern blotting, array or microarray hybridization, by enzymatic cleavage of specific structures (e.g., an Invader® assay, Third Wave Technologies, e.g. as described in U.S. Pat. Nos. 5,846,717, 6,090,543; 6,001,567; 5,985,557; and 5,994,069) and amplification methods, e.g. RT-PCR, including in a TaqMan® assay (PE Biosystems, Foster City, Calif., e.g. as described in U.S. Pat. Nos. 5,962,233 and 5,538,848), and may be quantitative or semi-quantitative, and may vary depending on the origin, amount and condition of the available biological sample. Combinations of these methods may also be used. For example, nucleic acids may be amplified, labeled and subjected to microarray analysis. Single-molecule sequencing (e.g., Illumina, Helicos, PacBio, ABI SOLID), in situ hybridization, bead-array technologies (e.g., Luminex xMAP, Illumina BeadChips), branched DNA technology (e.g., Panomics, Genisphere).

The expressed target sequences can be directly detected and/or quantitated, or may be copied and/or amplified to allow detection of amplified copies of the expressed target sequences or its complement. In some embodiments, degraded and/or fragmented RNA can be usefully analyzed for expression levels of target sequences, for example RNA having an RNA integrity number of less than 8.

In some embodiments, quantitative RT-PCR assays are used to measure the expression level of target sequences depicted in SEQ IDs: 1-2114. In other embodiments, a GeneChip or microarray can be used to measure the expression of one or more of the target sequences.

Molecular assays measure the relative expression levels of the target sequences, which can be normalized to the expression levels of one or more control sequences, for example array control sequences and/or one or more housekeeping genes, for example GAPDH. Increased (or decreased) relative expression of the target sequences as described herein, including any of SEQ ID NOs:1-2114, may thus be used alone or in any combination with each other in the methods described herein. In addition, negative control probes may be included.

Diagnostic Samples

Diagnostic samples for use with the systems and in the methods of the present invention comprise nucleic acids suitable for providing RNAs expression information. In principle, the biological sample from which the expressed RNA is obtained and analyzed for target sequence expression can be any material suspected of comprising prostate cancer tissue or cells. The diagnostic sample can be a biological sample used directly in a method of the invention. Alternatively, the diagnostic sample can be a sample prepared from a biological sample.

In one embodiments, the sample or portion of the sample comprising or suspected of comprising prostate cancer tissue or cells can be any source of biological material, including cells, tissue or fluid, including bodily fluids. Non-limiting examples of the source of the sample include an aspirate, a needle biopsy, a cytology pellet, a bulk tissue preparation or a section thereof obtained for example by surgery or autopsy, lymph fluid, blood, plasma, serum, tumors, and organs.

The samples may be archival samples, having a known and documented medical outcome, or may be samples from current patients whose ultimate medical outcome is not yet known.

In some embodiments, the sample may be dissected prior to molecular analysis. The sample may be prepared via macrodissection of a bulk tumor specimen or portion thereof, or may be treated via microdissection, for example via Laser Capture Microdissection (LCM).

The sample may initially be provided in a variety of states, as fresh tissue, fresh frozen tissue, fine needle aspirates, and may be fixed or unfixed. Frequently, medical laboratories routinely prepare medical samples in a fixed state, which facilitates tissue storage. A variety of fixatives can be used to fix tissue to stabilize the morphology of cells, and may be used alone or in combination with other agents. Exemplary fixatives include crosslinking agents, alcohols, acetone, Bouin's solution, Zenker solution, Hely solution, osmic acid solution and Carnoy solution.

Crosslinking fixatives can comprise any agent suitable for forming two or more covalent bonds, for example an aldehyde. Sources of aldehydes typically used for fixation include formaldehyde, paraformaldehyde, glutaraldehyde or formalin. Preferably, the crosslinking agent comprises formaldehyde, which may be included in its native form or in the form of paraformaldehyde or formalin. One of skill in the art would appreciate that for samples in which crosslinking fixatives have been used special preparatory steps may be necessary including for example heating steps and proteinase-k digestion; see methods

One or more alcohols may be used to fix tissue, alone or in combination with other fixatives. Exemplary alcohols used for fixation include methanol, ethanol and isopropanol.

Formalin fixation is frequently used in medical laboratories. Formalin comprises both an alcohol, typically methanol, and formaldehyde, both of which can act to fix a biological sample.

Whether fixed or unfixed, the biological sample may optionally be embedded in an embedding medium. Exemplary embedding media used in histology including paraffin, Tissue-Tek® V.I.P.™, Paramat, Paramat Extra, Paraplast, Paraplast X-tra, Paraplast Plus, Peel Away Paraffin Embedding Wax, Polyester Wax, Carbowax Polyethylene Glycol, Polyfin™, Tissue Freezing Medium TFM™, Cryo-Gel™, and OCT Compound (Electron Microscopy Sciences, Hatfield, Pa.). Prior to molecular analysis, the embedding material may be removed via any suitable techniques, as known in the art. For example, where the sample is embedded in wax, the embedding material may be removed by extraction with organic solvent(s), for example xylenes. Kits are commercially available for removing embedding media from tissues. Samples or sections thereof may be subjected to further processing steps as needed, for example serial hydration or dehydration steps.

In some embodiments, the sample is a fixed, wax-embedded biological sample. Frequently, samples from medical laboratories are provided as fixed, wax-embedded samples, most commonly as formalin-fixed, paraffin embedded (FFPE) tissues.

Whatever the source of the biological sample, the target polynucleotide that is ultimately assayed can be prepared synthetically (in the case of control sequences), but typically is purified from the biological source and subjected to one or more preparative steps. The RNA may be purified to remove or diminish one or more undesired components from the biological sample or to concentrate it. Conversely, where the RNA is too concentrated for the particular assay, it may be diluted.

RNA Extraction

RNA can be extracted and purified from biological samples using any suitable technique. A number of techniques are known in the art, and several are commercially available (e.g., FormaPure™ nucleic acid extraction kit, Agencourt Biosciences, Beverly Mass., High Pure FFPE RNA Micro Kit™, Roche Applied Science, Indianapolis, Ind.). RNA can be extracted from frozen tissue sections using TRIzol (Invitrogen, Carlsbad, Calif.) and purified using RNeasy Protect kit (Qiagen, Valencia, Calif.). RNA can be further purified using DNAse I treatment (Ambion, Austin, Tex.) to eliminate any contaminating DNA. RNA concentrations can be made using a Nanodrop ND-1000 spectrophotometer (Nanodrop Technologies, Rockland, Del.). RNA integrity can be evaluated by running electropherograms, and RNA integrity number (RIN, a correlative measure that indicates intactness of mRNA) can be determined using the RNA 6000 PicoAssay for the Bioanalyzer 2100 (Agilent Technologies, Santa Clara, Calif.).

Reverse Transcription for QRT-PCR Analysis

Reverse transcription can be performed using the Omniscript kit (Qiagen, Valencia, Calif.), Superscript III kit (Invitrogen, Carlsbad, Calif.), for RT-PCR. Target-specific priming can be performed in order to increase the sensitivity of detection of target sequences and generate target-specific cDNA.

TaqMan® Gene Expression Analysis

TaqMan® RT-PCR can be performed using Applied Biosystems Prism (ABI) 7900 HT instruments in a 5 μl volume with target sequence-specific cDNA equivalent to 1 ng total RNA. Primers and probes concentrations for TaqMan analysis are added to amplify fluorescent amplicons using PCR cycling conditions such as 95° C. for 10 minutes for one cycle, 95° C. for 20 seconds, and 60° C. for 45 seconds for 40 cycles. A reference sample can be assayed to ensure reagent and process stability. Negative controls (i.e., no template) should be assayed to monitor any exogenous nucleic acid contamination.

Amplification and Hybridization

Following sample collection and nucleic acid extraction, the nucleic acid portion of the sample comprising RNA that is or can be used to prepare the target polynucleotide(s) of interest can be subjected to one or more preparative reactions. These preparative reactions can include in vitro transcription (IVT), labeling, fragmentation, amplification and other reactions. mRNA can first be treated with reverse transcriptase and a primer to create cDNA prior to detection, quantitation and/or amplification; this can be done in vitro with purified mRNA or in situ, e.g., in cells or tissues affixed to a slide.

By “amplification” is meant any process of producing at least one copy of a nucleic acid, in this case an expressed RNA, and in many cases produces multiple copies. An amplification product can be RNA or DNA, and may include a complementary strand to the expressed target sequence. DNA amplification products can be produced initially through reverse translation and then optionally from further amplification reactions. The amplification product may include all or a portion of a target sequence, and may optionally be labeled. A variety of amplification methods are suitable for use, including polymerase-based methods and ligation-based methods. Exemplary amplification techniques include the polymerase chain reaction method (PCR), the ligase chain reaction (LCR), ribozyme-based methods, self sustained sequence replication (3SR), nucleic acid sequence-based amplification (NASBA), the use of Q Beta replicase, reverse transcription, nick translation, and the like.

Asymmetric amplification reactions may be used to preferentially amplify one strand representing the target sequence that is used for detection as the target polynucleotide. In some cases, the presence and/or amount of the amplification product itself may be used to determine the expression level of a given target sequence. In other instances, the amplification product may be used to hybridize to an array or other substrate comprising sensor polynucleotides which are used to detect and/or quantitate target sequence expression.

The first cycle of amplification in polymerase-based methods typically forms a primer extension product complementary to the template strand. If the template is single-stranded RNA, a polymerase with reverse transcriptase activity is used in the first amplification to reverse transcribe the RNA to DNA, and additional amplification cycles can be performed to copy the primer extension products. The primers for a PCR must, of course, be designed to hybridize to regions in their corresponding template that will produce an amplifiable segment; thus, each primer must hybridize so that its 3′ nucleotide is paired to a nucleotide in its complementary template strand that is located 3′ from the 3′ nucleotide of the primer used to replicate that complementary template strand in the PCR.

The target polynucleotide can be amplified by contacting one or more strands of the target polynucleotide with a primer and a polymerase having suitable activity to extend the primer and copy the target polynucleotide to produce a full-length complementary polynucleotide or a smaller portion thereof. Any enzyme having a polymerase activity that can copy the target polynucleotide can be used, including DNA polymerases, RNA polymerases, reverse transcriptases, enzymes having more than one type of polymerase or enzyme activity. The enzyme can be thermolabile or thermostable. Mixtures of enzymes can also be used. Exemplary enzymes include: DNA polymerases such as DNA Polymerase I (“Pol I”), the Klenow fragment of Pol I, T4, T7, Sequenase® T7, Sequenase® Version 2.0 T7, Tub, Taq, Tth, Pfx, Pfu, Tsp, Tfl, Tli and Pyrococcus sp GB-D DNA polymerases; RNA polymerases such as E. coli, SP6, T3 and T7 RNA polymerases; and reverse transcriptases such as AMV, M-MuLV, MMLV, RNAse H⁻ MMLV (SuperScript®), SuperScript® II, ThermoScript®, HIV-1, and RAV2 reverse transcriptases. All of these enzymes are commercially available. Exemplary polymerases with multiple specificities include RAV2 and Tli (exo-) polymerases. Exemplary thermostable polymerases include Tub, Taq, Tth, Pfx, Pfu, Tsp, Tfl, Tli and Pyrococcus sp. GB-D DNA polymerases.

Suitable reaction conditions are chosen to permit amplification of the target polynucleotide, including pH, buffer, ionic strength, presence and concentration of one or more salts, presence and concentration of reactants and cofactors such as nucleotides and magnesium and/or other metal ions (e.g., manganese), optional cosolvents, temperature, thermal cycling profile for amplification schemes comprising a polymerase chain reaction, and may depend in part on the polymerase being used as well as the nature of the sample. Cosolvents include formamide (typically at from about 2 to about 10%), glycerol (typically at from about 5 to about 10%), and DMSO (typically at from about 0.9 to about 10%). Techniques may be used in the amplification scheme in order to minimize the production of false positives or artifacts produced during amplification. These include “touchdown” PCR, hot-start techniques, use of nested primers, or designing PCR primers so that they form stem-loop structures in the event of primer-dimer formation and thus are not amplified. Techniques to accelerate PCR can be used, for example centrifugal PCR, which allows for greater convection within the sample, and comprising infrared heating steps for rapid heating and cooling of the sample. One or more cycles of amplification can be performed. An excess of one primer can be used to produce an excess of one primer extension product during PCR; preferably, the primer extension product produced in excess is the amplification product to be detected. A plurality of different primers may be used to amplify different target polynucleotides or different regions of a particular target polynucleotide within the sample.

An amplification reaction can be performed under conditions which allow an optionally labeled sensor polynucleotide to hybridize to the amplification product during at least part of an amplification cycle. When the assay is performed in this manner, real-time detection of this hybridization event can take place by monitoring for light emission or fluorescence during amplification, as known in the art.

Where the amplification product is to be used for hybridization to an array or microarray, a number of suitable commercially available amplification products are available. These include amplification kits available from NuGEN, Inc. (San Carlos, Calif.), including the WT-Ovation™ System, WT-Ovation™ System v2, WT-Ovation™ Pico System, WT-Ovation™ FFPE Exon Module, WT-Ovation™ FFPE Exon Module RiboAmp and RiboAmp^Plus RNA Amplification Kits (MDS Analytical Technologies (formerly Arcturus) (Mountain View, Calif.), Genisphere, Inc. (Hatfield, Pa.), including the RampUp Plus™ and SenseAmp™ RNA Amplification kits, alone or in combination. Amplified nucleic acids may be subjected to one or more purification reactions after amplification and labeling, for example using magnetic beads (e.g., RNAClean magnetic beads, Agencourt Biosciences).

Multiple RNA biomarkers can be analyzed using real-time quantitative multiplex RT-PCR platforms and other multiplexing technologies such as GenomeLab GeXP Genetic Analysis System (Beckman Coulter, Foster City, Calif.), SmartCycler® 9600 or GeneXpert(R) Systems (Cepheid, Sunnyvale, Calif.), ABI 7900 HT Fast Real Time PCR system (Applied Biosystems, Foster City, Calif.), LightCycler® 480 System (Roche Molecular Systems, Pleasanton, Calif.), xMAP 100 System (Luminex, Austin, Tex.) Solexa Genome Analysis System (Illumina, Hayward, Calif.), OpenArray Real Time qPCR (BioTrove, Woburn, Mass.) and BeadXpress System (Illumina, Hayward, Calif.).

Prostate Classification Arrays

The present invention contemplates that a Prostate Cancer Prognostic Set or probes derived therefrom may be provided in an array format. In the context of the present invention, an “array” is a spatially or logically organized collection of polynucleotide probes. Any array comprising sensor probes specific for two or more of SEQ ID NOs: 1-2114 or a product derived therefrom can be used. Desirably, an array will be specific for 5, 10, 15, 20, 25, 30, 50, 75, 100, 150, 200, 250, 300, 350, 400, 450, 500, 600, 700, 1000, 1200, 1400, 1600, 1800, 2000 or more of SEQ ID NOs: 1-2114. Expression of these sequences may be detected alone or in combination with other transcripts. In some embodiments, an array is used which comprises a wide range of sensor probes for prostate-specific expression products, along with appropriate control sequences. An array of interest is the Human Exon 1.0 ST Array (HuEx 1.0 ST, Affymetrix, Inc., Santa Clara, Calif.).

Typically the polynucleotide probes are attached to a solid substrate and are ordered so that the location (on the substrate) and the identity of each are known. The polynucleotide probes can be attached to one of a variety of solid substrates capable of withstanding the reagents and conditions necessary for use of the array. Examples include, but are not limited to, polymers, such as (poly)tetrafluoroethylene, (poly)vinylidenedifluoride, polystyrene, polycarbonate, polypropylene and polystyrene; ceramic; silicon; silicon dioxide; modified silicon; (fused) silica, quartz or glass; functionalized glass; paper, such as filter paper; diazotized cellulose; nitrocellulose filter; nylon membrane; and polyacrylamide gel pad. Substrates that are transparent to light are useful for arrays that will be used in an assay that involves optical detection.

Examples of array formats include membrane or filter arrays (for example, nitrocellulose, nylon arrays), plate arrays (for example, multiwell, such as a 24-, 96-, 256-, 384-, 864- or 1536-well, microtitre plate arrays), pin arrays, and bead arrays (for example, in a liquid “slurry”). Arrays on substrates such as glass or ceramic slides are often referred to as chip arrays or “chips.” Such arrays are well known in the art. In one embodiment of the present invention, the Prostate Cancer Prognosticarray is a chip.

Data Analysis

Array data can be managed and analyzed using techniques known in the art. The Genetrix suite of tools can be used for microarray analysis (Epicenter Software, Pasadena, Calif.). Probe set modeling and data pre-processing can be derived using the Robust Multi-Array (RMA) algorithm or variant GC-RMA, Probe Logarithmic Intensity Error (PLIER) algorithm or variant iterPLIER. Variance or intensity filters can be applied to pre-process data using the RMA algorithm, for example by removing target sequences with a standard deviation of <10 or a mean intensity of <100 intensity units of a normalized data range, respectively.

In some embodiments, one or more pattern recognition methods can be used in analyzing the expression level of target sequences. The pattern recognition method can comprise a linear combination of expression levels, or a nonlinear combination of expression levels. In some embodiments, expression measurements for RNA transcripts or combinations of RNA transcript levels are formulated into linear or non-linear models or algorithms (i.e., an ‘expression signature’) and converted into a likelihood score. This likelihood score indicates the probability that a biological sample is from a patient who will exhibit no evidence of disease, who will exhibit systemic cancer, or who will exhibit biochemical recurrence. The likelihood score can be used to distinguish these disease states. The models and/or algorithms can be provided in machine readable format, and may be used to correlate expression levels or an expression profile with a disease state, and/or to designate a treatment modality for a patient or class of patients.

Thus, results of the expression level analysis can be used to correlate increased expression of RNAs corresponding to SEQ ID NOs: 1-2114, or subgroups thereof as described herein, with prostate cancer outcome, and to designate a treatment modality.

Factors known in the art for diagnosing and/or suggesting, selecting, designating, recommending or otherwise determining a course of treatment for a patient or class of patients suspected of having prostate cancer can be employed in combination with measurements of the target sequence expression. These techniques include cytology, histology, ultrasound analysis, MRI results, CT scan results, and measurements of PSA levels.

Certified tests for classifying prostate disease status and/or designating treatment modalities are also provided. A certified test comprises a means for characterizing the expression levels of one or more of the target sequences of interest, and a certification from a government regulatory agency endorsing use of the test for classifying the prostate disease status of a biological sample.

In some embodiments, the certified test may comprise reagents for amplification reactions used to detect and/or quantitate expression of the target sequences to be characterized in the test. An array of probe nucleic acids can be used, with or without prior target amplification, for use in measuring target sequence expression.

The test is submitted to an agency having authority to certify the test for use in distinguishing prostate disease status and/or outcome. Results of detection of expression levels of the target sequences used in the test and correlation with disease status and/or outcome are submitted to the agency. A certification authorizing the diagnostic and/or prognostic use of the test is obtained.

Also provided are portfolios of expression levels comprising a plurality of normalized expression levels of the target sequences described herein, including SEQ ID NOs:1-2114. Such portfolios may be provided by performing the methods described herein to obtain expression levels from an individual patient or from a group of patients. The expression levels can be normalized by any method known in the art; exemplary normalization methods that can be used in various embodiments include Robust Multichip Average (RMA), probe logarithmic intensity error estimation (PLIER), non-linear fit (NLFIT) quantile-based and nonlinear normalization, and combinations thereof. Background correction can also be performed on the expression data; exemplary techniques useful for background correction include mode of intensities, normalized using median polish probe modeling and sketch-normalization.

In some embodiments, portfolios are established such that the combination of genes in the portfolio exhibit improved sensitivity and specificity relative to known methods. In considering a group of genes for inclusion in a portfolio, a small standard deviation in expression measurements correlates with greater specificity. Other measurements of variation such as correlation coefficients can also be used in this capacity. The invention also encompasses the above methods where the specificity is at least about 50% or at least about 60%. The invention also encompasses the above methods where the sensitivity is at least about 90%.

The gene expression profiles of each of the target sequences comprising the portfolio can fixed in a medium such as a computer readable medium. This can take a number of forms. For example, a table can be established into which the range of signals (e.g., intensity measurements) indicative of disease or outcome is input. Actual patient data can then be compared to the values in the table to determine the patient samples diagnosis or prognosis. In a more sophisticated embodiment, patterns of the expression signals (e.g., fluorescent intensity) are recorded digitally or graphically.

The expression profiles of the samples can be compared to a control portfolio. If the sample expression patterns are consistent with the expression pattern for a known disease or disease outcome, the expression patterns can be used to designate one or more treatment modalities. For patients with test scores consistent with systemic disease outcome after prostatectomy, additional treatment modalities such as adjuvant chemotherapy (e.g., docetaxel, mitoxantrone and prednisone), systemic radiation therapy (e.g., samarium or strontium) and/or anti-androgen therapy (e.g., surgical castration, finasteride, dutasteride) can be designated. Such patients would likely be treated immediately with anti-androgen therapy alone or in combination with radiation therapy in order to eliminate presumed micro-metastatic disease, which cannot be detected clinically but can be revealed by the target sequence expression signature. Such patients can also be more closely monitored for signs of disease progression. For patients with test scores consistent with PSA or NED, adjuvant therapy would not likely be recommended by their physicians in order to avoid treatment-related side effects such as metabolic syndrome (e.g., hypertension, diabetes and/or weight gain) or osteoporosis. Patients with samples consistent with NED could be designated for watchful waiting, or for no treatment. Patients with test scores that do not correlate with systemic disease but who have successive PSA increases could be designated for watchful waiting, increased monitoring, or lower dose or shorter duration anti-androgen therapy.

Target sequences can be grouped so that information obtained about the set of target sequences in the group can be used to make or assist in making a clinically relevant judgment such as a diagnosis, prognosis, or treatment choice.

A patient report is also provided comprising a representation of measured expression levels of a plurality of target sequences in a biological sample from the patient, wherein the representation comprises expression levels of target sequences corresponding to any one, two, three, four, five, six, eight, ten, twenty, thirty, fifty or more of the target sequences depicted in SEQ ID NOs: 1-2114, or of the subsets described herein, or of a combination thereof. In some embodiments, the representation of the measured expression level(s) may take the form of a linear or nonlinear combination of expression levels of the target sequences of interest. The patient report may be provided in a machine (e.g., a computer) readable format and/or in a hard (paper) copy. The report can also include standard measurements of expression levels of said plurality of target sequences from one or more sets of patients with known disease status and/or outcome. The report can be used to inform the patient and/or treating physician of the expression levels of the expressed target sequences, the likely medical diagnosis and/or implications, and optionally may recommend a treatment modality for the patient.

Also provided are representations of the gene expression profiles useful for treating, diagnosing, prognosticating, and otherwise assessing disease. In some embodiments, these profile representations are reduced to a medium that can be automatically read by a machine such as computer readable media (magnetic, optical, and the like). The articles can also include instructions for assessing the gene expression profiles in such media. For example, the articles may comprise a readable storage form having computer instructions for comparing gene expression profiles of the portfolios of genes described above. The articles may also have gene expression profiles digitally recorded therein so that they may be compared with gene expression data from patient samples. Alternatively, the profiles can be recorded in different representational format. A graphical recordation is one such format. Clustering algorithms can assist in the visualization of such data.

Kits

Kits for performing the desired method(s) are also provided, and comprise a container or housing for holding the components of the kit, one or more vessels containing one or more nucleic acid(s), and optionally one or more vessels containing one or more reagents. The reagents include those described in the composition of matter section above, and those reagents useful for performing the methods described, including amplification reagents, and may include one or more probes, primers or primer pairs, enzymes (including polymerases and ligases), intercalating dyes, labeled probes, and labels that can be incorporated into amplification products.

In some embodiments, the kit comprises primers or primer pairs specific for those subsets and combinations of target sequences described herein. At least two, three, four or five primers or pairs of primers suitable for selectively amplifying the same number of target sequence-specific polynucleotides can be provided in kit form. In some embodiments, the kit comprises from five to fifty primers or pairs of primers suitable for amplifying the same number of target sequence-representative polynucleotides of interest.

The primers or primer pairs of the kit, when used in an amplification reaction, specifically amplify at least a portion of a nucleic acid depicted in one of SEQ ID NOs: 1-2114 (or subgroups thereof as set forth herein), an RNA form thereof, or a complement to either thereof. The kit may include a plurality of such primers or primer pairs which can specifically amplify a corresponding plurality of different nucleic acids depicted in one of SEQ ID NOs: 1-2114 (or subgroups thereof as set forth herein), RNA forms thereof, or complements thereto. At least two, three, four or five primers or pairs of primers suitable for selectively amplifying the same number of target sequence-specific polynucleotides can be provided in kit form. In some embodiments, the kit comprises from five to fifty primers or pairs of primers suitable for amplifying the same number of target sequence-representative polynucleotides of interest.

The reagents may independently be in liquid or solid form. The reagents may be provided in mixtures. Control samples and/or nucleic acids may optionally be provided in the kit. Control samples may include tissue and/or nucleic acids obtained from or representative of prostate tumor samples from patients showing no evidence of disease, as well as tissue and/or nucleic acids obtained from or representative of prostate tumor samples from patients that develop systemic prostate cancer.

The nucleic acids may be provided in an array format, and thus an array or microarray may be included in the kit. The kit optionally may be certified by a government agency for use in prognosing the disease outcome of prostate cancer patients and/or for designating a treatment modality.

Instructions for using the kit to perform one or more methods of the invention can be provided with the container, and can be provided in any fixed medium. The instructions may be located inside or outside the container or housing, and/or may be printed on the interior or exterior of any surface thereof. A kit may be in multiplex form for concurrently detecting and/or quantitating one or more different target polynucleotides representing the expressed target sequences.

Devices

Devices useful for performing methods of the invention are also provided. The devices can comprise means for characterizing the expression level of a target sequence of the invention, for example components for performing one or more methods of nucleic acid extraction, amplification, and/or detection. Such components may include one or more of an amplification chamber (for example a thermal cycler), a plate reader, a spectrophotometer, capillary electrophoresis apparatus, a chip reader, and or robotic sample handling components. These components ultimately can obtain data that reflects the expression level of the target sequences used in the assay being employed.

The devices may include an excitation and/or a detection means. Any instrument that provides a wavelength that can excite a species of interest and is shorter than the emission wavelength(s) to be detected can be used for excitation. Commercially available devices can provide suitable excitation wavelengths as well as suitable detection components.

Exemplary excitation sources include a broadband UV light source such as a deuterium lamp with an appropriate filter, the output of a white light source such as a xenon lamp or a deuterium lamp after passing through a monochromator to extract out the desired wavelength(s), a continuous wave (cw) gas laser, a solid state diode laser, or any of the pulsed lasers. Emitted light can be detected through any suitable device or technique; many suitable approaches are known in the art. For example, a fluorimeter or spectrophotometer may be used to detect whether the test sample emits light of a wavelength characteristic of a label used in an assay.

The devices typically comprise a means for identifying a given sample, and of linking the results obtained to that sample. Such means can include manual labels, barcodes, and other indicators which can be linked to a sample vessel, and/or may optionally be included in the sample itself, for example where an encoded particle is added to the sample. The results may be linked to the sample, for example in a computer memory that contains a sample designation and a record of expression levels obtained from the sample. Linkage of the results to the sample can also include a linkage to a particular sample receptacle in the device, which is also linked to the sample identity.

The devices also comprise a means for correlating the expression levels of the target sequences being studied with a prognosis of disease outcome. Such means may comprise one or more of a variety of correlative techniques, including lookup tables, algorithms, multivariate models, and linear or nonlinear combinations of expression models or algorithms. The expression levels may be converted to one or more likelihood scores, reflecting a likelihood that the patient providing the sample will exhibit a particular disease outcome. The models and/or algorithms can be provided in machine readable format, and can optionally further designate a treatment modality for a patient or class of patients.

The device also comprises output means for outputting the disease status, prognosis and/or a treatment modality. Such output means can take any form which transmits the results to a patient and/or a healthcare provider, and may include a monitor, a printed format, or both. The device may use a computer system for performing one or more of the steps provided.

CITATIONS

Patents and Published Applications

• 1. US 2003/0224399 A1 patent application Methods for determining the prognosis for patients with a prostate neoplastic condition 2003 Dec. 4
• 2. US 2007/0048738 A1 patent application Methods and compositions for diagnosis, staging and prognosis of prostate cancer 2007 Mar. 1
• 3. US 2007/0099197 A1 patent application Methods of prognosis of prostate cancer 2007 May 3
• 4. US 2007/0259352 A1 patent application Prostate cancer-related nucleic acids 2007 Nov. 8
• 5. US 2008/0009001 A1 patent application Method for Identification of Neoplastic Transformation with Particular Reference to Prostate Cancer 2008 Jan. 10

Publications

• 1: Cooper C S, Campbell C, Jhavar S. Mechanisms of Disease: biomarkers and molecular targets from microarray gene expression studies in prostate cancer. Nat Clin Pract Urol. 2007 December; 4(12):677-87. Review.
• 2: Reddy G K, Balk S P. Clinical utility of microarray-derived genetic signatures in predicting outcomes in prostate cancer. Clin Genitourin Cancer. 2006 December; 5(3):187-9. Review.
• 3: Nelson P S. Predicting prostate cancer behavior using transcript profiles. J Urol. 2004 November; 172(5 Pt 2):S28-32; discussion S33. Review.
• 4: Bibikova M, Chudin E, Arsanjani A, Zhou L, Garcia E W, Modder J, Kostelec M, Barker D, Downs T, Fan J B, Wang-Rodriguez J. Expression signatures that correlated with Gleason score and relapse in prostate cancer. Genomics. 2007 June; 89(6):666-72. Epub 2007 Apr. 24.
• 5: Schlomm T, Erbersdobler A, Mirlacher M, Sauter G. Molecular staging of prostate cancer in the year 2007. World J Urol. 2007 March; 25(1):19-30. Epub 2007 Mar. 2. Review.
• 6: Mendiratta P, Febbo P G. Genomic signatures associated with the development, progression, and outcome of prostate cancer. Mol Diagn Ther. 2007; 11(6):345-54.
• 7: Reddy G K, Balk S P. Clinical utility of microarray-derived genetic signatures in predicting outcomes in prostate cancer. Clin Genitourin Cancer. 2006 December; 5(3):187-9. Review.
• 8: True L, Coleman I, Hawley S, Huang C Y, Gifford D, Coleman R, Beer T M, Gelmann E, Datta M, Mostaghel E, Knudsen B, Lange P, Vessella R, Lin D, Hood L, Nelson P S. A molecular correlate to the Gleason grading system for prostate adenocarcinoma. Proc Natl Acad Sci USA. 2006 Jul. 18; 103(29):10991-6. Epub 2006 Jul. 7.
• 9: Stephenson A J, Smith A, Kattan M W, Satagopan J, Reuter V E, Scardino P T, Gerald W L. Integration of gene expression profiling and clinical variables to predict prostate carcinoma recurrence after radical prostatectomy. Cancer. 2005 Jul. 15; 104(2):290-8.
• 10: Bueno R, Loughlin K R, Powell M H, Gordon G J. A diagnostic test for prostate cancer from gene expression profiling data. J Urol. 2004 February; 171(2 Pt 1):903-6.
• 11: Yu Y P, Landsittel D, Jing L, Nelson J, Ren B, Liu L, McDonald C, Thomas R, Dhir R, Finkelstein S, Michalopoulos G, Becich M, Luo J H. Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol. 2004 Jul. 15; 22(14):2790-9.
• 12: Feroze-Merzoug F, Schober M S, Chen Y Q. Molecular profiling in prostate cancer. Cancer Metastasis Rev. 2001; 20(3-4):165-71. Review.
• 13: Nakagawa T, Kollmeyer T M, Morlan B W, Anderson S K, Bergstralh E J, Davis B J, Asmann Y W, Klee G G, Ballman K V, Jenkins R B. A tissue biomarker panel predicting systemic progression after PSA recurrence post-definitive prostate cancer therapy. PLoS ONE. 2008; 3(5):e2318.
• 14: Shariat S F, Karakiewicz P I, Roehrborn C G, Kattan M W. An updated catalog of prostate cancer predictive tools. Cancer 2008; 113(11): 3062-6.

EXAMPLES

To gain a better understanding of the invention described herein, the following examples are set forth. It will be understood that these examples are intended to describe illustrative embodiments of the invention and are not intended to limit the scope of the invention in any way. Efforts have been made to ensure accuracy with respect to numbers used (e.g., amounts, temperature, etc.) but some experimental error and deviation should be accounted for. Unless otherwise indicated, parts are parts by weight, temperature is degree centigrade and pressure is at or near atmospheric, and all materials are commercially available.

Example 1

Identification of Target Sequences Differentially Expressed in Prostate Disease States

Tissue Samples. Formalin-fixed paraffin embedded (FFPE) samples of human prostate adenocarcinoma prostatectomies were collected from patients at the Mayo Clinic Comprehensive Cancer Center according to an institutional review board-approved protocol and stored in the Department of Pathology for up to 20 years. For each patient sample four 4 micron sections were cut from formalin-fixed paraffin embedded blocks. Pathological review of FFPE tissue sections was used to guide macrodissection of tumor and surrounding normal tissue. Patients were classified into one of three clinical disease states; no evidence of disease (NED, n=10) for those patients with no biochemical or other clinical signs of disease progression (at least 10 years follow-up); prostate-specific antigen biochemical recurrence (PSA, n=10) for those patients with two successive increases in PSA measurements above an established cut-point of >4 ng/mL (‘rising PSA’); and systemic disease (SYS, n=10) for those patients that had ‘rising PSA’ and developed metastases or clinically detectable disease progression within five years after initial prostatectomy. Clinical disease was confirmed using bone or CT scans for prostate cancer metastases.

RNA Extraction. RNA was extracted and purified from FFPE tissue sections using a modified protocol for the commercially available High Pure FFPE RNA Micro nucleic acid extraction kit (Roche Applied Sciences, Indianapolis, Ind.). RNA concentrations were calculated using a Nanodrop ND-1000 spectrophotometer (Nanodrop Technologies, Rockland, Del.).

RNA Amplification and GeneChip Hybridization. Purified RNA was subjected to whole-transcriptome amplification using the WT-Ovation FFPE system including the WT-Ovation Exon and FL-Ovation Biotin V2 labeling modules, with the following modifications. Fifty (50) nanograms of RNA extracted from FFPE sections was used to generate amplified Ribo-SPIA product. For the WT-Ovation Exon sense-target strand conversion kit 4 ug of Ribo-SPIA product were used. All clean-up steps were performed with RNAClean magnetic beads (Agencourt Biosciences). Between 2.5 and 5 micrograms of WT-Ovation Exon product were used to fragment and label using the FL-Ovation Biotin V2 labeling module and labeled product was hybridized to Affymetrix Human Exon 1.0 ST GeneChips following manufacturer's recommendations (Affymetrix, Santa Clara, Calif.). Of the 30 samples processed, 22 had sufficient amplified material (i.e., >2.5 ug of WT-Ovation Exon product) for GeneChip hybridization.

Microarray Analysis. All data management and analysis was conducted using the Genetrix suite of tools for microarray analysis (Epicenter Software, Pasadena, Calif.). Probe set modeling and data pre-processing were derived using the Robust Multi-Array (RMA) algorithm. The mode of intensity values was used for background correction and RMA-sketch was used for normalization and probe modeling used a median polish routine. A variance filter was applied to data pre-processed using the RMA algorithm, by removing target sequences with a mean intensity of <10 intensity units of a normalized data range. Target sequences typically comprise four individual probes that interrogate the expression of RNA transcripts or portions thereof. Target sequence annotations and the sequences (RNAs) that they interrogate were downloaded from the Affymetrix website (www.netaffx.com). Supervised analysis of differentially expressed RNA transcripts was determined based on the fold change in the average expression (at least 2 fold change) and the associated t-test, with a p-value cut-off of p<0.001 between different prostate cancer patient disease states. Linear regression was also used to screen differentially expressed transcripts that displayed an expression pattern of NED>PSA>SYS or SYS>PSA>NED and genes were selected with a p-value cut-off of p<0.01 for two-way hierarchical clustering using Pearson's correlation distance metric with complete-linkage cluster distances.

Archived FFPE blocks of tumors were selected from 30 patients that had undergone a prostatectomy at the Mayo Clinic Comprehensive Cancer Center between the years 1987-1997, providing for at least 10 years follow-up on each patient. Twenty-two patient samples had RNA of sufficient quantity and quality for RNA amplification and subsequent GeneChip hybridization. Three clinical categories of patients were evaluated; patients alive with no evidence of disease (‘NED’, n=6), patients with rising PSA or biochemical recurrence (defined as two successive increases in PSA measurements) (‘PSA’, n=7) and patients with rising PSA and clinical evidence of systemic or recurrent disease (e.g., determined by bone scan, CT) (‘SYS’, n=9) after prostatectomy. No statistically significant differences between these three clinical groups were apparent when considering pathological factors such as Gleason score or tumor stage (Table 1). As samples from older archived FFPE blocks are typically more degraded and fragmented than younger blocks, the distribution of block ages was similar in the three clinical groups so as not to skew or bias the results due to a block age effect. Fifty nanograms of RNA extracted from FFPE sections was amplified and hybridized to whole-transcriptome microarrays, interrogating >1.4 million probe target sequences measuring RNA levels for RefSeq, dbEST and predicted transcripts (collectively, ‘RNAs’).

Table 3 displays the number of target sequences identified in two-way comparisons between different clinical states using the appropriate t-tests and a p-value cut-off of p<0.001. At total of 2,114 target sequences (Table 3) were identified as differentially expressed in these comparisons and a principle components analysis demonstrates that these target sequences discriminate the distinct clinical states into three clusters (FIG. 1A).

A linear regression filter was next employed to statistically rank target sequences that followed a trend of either increased expression with poor prognosis patients (i.e., SYS>PSA>NED) or increased expression in good prognosis patients (NED>PSA>SYS, alternatively decreased expression in poor prognosis patients) (Table 4). FIG. 1B depicts a two-way hierarchical clustering dendrogram and expression matrix of top-ranked 526 target sequences and 22 tumor samples. Patients in the ‘PSA’ clinical status category displayed intermediate expression levels for genes expressed at increased levels in SYS (n=313) and NED (n=213), respectively (Table 4). FIG. 1C depicts a two-way hierarchical clustering dendrogram and expression matrix of 148 target sequences and 22 tumor samples. These target sequences were a subset of the differentially expressed transcripts (Table 3) filtered using a t-test to query ‘recurrent’ (i.e., ‘SYS’) and ‘non-recurrent’ (i.e., ‘PSA’ and ‘NED’) patient samples (Table 5).

The expression levels of these genes were summarized for each patient into a ‘metagene’ using a simple linear combination by taking the expression level and multiplying it by a weighting factor for each target sequence in the metagene signature and combining these values into a single variable. Weighting factors were derived from the coefficients of the linear regression fit analysis (Table 4). FIG. 2 shows a histogram plot of the metagene expression values for the summarized 526 target sequences in each of the three clinical groups. This 526-metagene achieved maximal separation between clinical groups and low variance within each clinical group. Metagenes comprised of smaller subsets of 21, 18 and 6 target sequences were also generated (FIG. 3, Tables 7 and 8). The distinctions between clinical groups with respect to the metagene scores were preserved, although increased within-group variance was observed when using fewer target sequences (FIG. 3).

Next, Patient outcome predictor (‘POP’) scores were generated from the metagene values for each patient. For the 18-target sequences metagene, this entailed scaling and normalizing the metagene scores within a range of 0 to 100, where a value of between 0-20 points indicates a patient with NED, 40-60 points a patient with PSA recurrence and 80-100 points a patient with SYS metastatic disease (FIG. 4). In contrast, Gleason scores for patients could not be used on their own to distinguish the clinical groups (Table 1).

Using the Nearest Shrunken Centroids (NSC) algorithm with leave-1-out cross-validation, smaller subsets of RNA transcripts were identified that distinguish ‘recurrent’ (i.e., ‘SYS’) and ‘non-recurrent’ (i.e., ‘PSA’ and ‘NED’) disease (Tables 9 and 10). NSC algorithm identified 10- and 41-target sequence metagenes used to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. FIGS. 5 and 6 depict box plots showing interquartile range and distribution of ‘POP’ scores for each clinical group. A 148-target sequence metagene (Table 5) was similarly used to derive ‘POP’ scores depicted in FIG. 7. T-tests were used to evaluate the statistical significance of differences in POP scores between ‘recurrent’ (i.e., ‘SYS’) and non-recurrent (i.e., ‘PSA’ and ‘NED’) patient groups (indicated in the figures) and show that increasing the number of target sequences in the metagene combination increases the significance level of the differences in POP scores.

The data generated from such methods can be used to determine a prognosis for disease outcome, and/or to recommend or designate one or more treatment modalities for patients, to produce patient reports, and to prepare expression profiles.

TABLE 1
Clinical characteristics of different clinical status patient groups evaluated.
Note Chi square tests for homogeneity reveal that the three clinical groups
do not show significant differences in terms of patient composition based
on known prognostic variables such as pathological TNM stage or Gleason
score. Also, the block age of the samples was not different between
clinical status groups; so that sample archive age effect is mitigated
(i.e., older samples have more degraded, fragmented nucleic acids that
could skew or bias results if not evenly distributed in clinical status
patient groups).

	NED	PSA	Systemic	X2 Tests for
	(n = 6)	(n = 7)	(n = 9)	Homegeneity

Pathological	T2N0	2	3	3	p < 0.07
Stage	T3aN0	1	4	1
	T3bN0	0	0	3
	TxN+	3	0	2
Gleason Score	7	2	7	4	p < 0.06
	8	3	0	2
	9	1	0	3
Block Age	10-14	3	4	5	p < 0.9
Group (years)	13-15	1	1	2
	16-20	2	2	2

TABLE 2
Comparison of differential expression between patient clinical
status groups. Two-way comparisons for differential expression
using the following statistical criteria: a) at least 2-fold mean
difference in expression between comparison groups;
b) expression levels >50 intensity units of a normalized data
range (approximately the mean expression level across all
transcripts in all samples) and c) significance cut-off of
p < 0.001 determined using a t-test.

	Clinical		Differentially
	Status	Comparison	Expressed RNAs*

	NED	vs PSA	316
	PSA	vs NED	442
	NED	vs SYS	213
	PSA	vs SYS	194
	SYS	vs NED	269
	SYS	vs PSA	323
	SYS	vs NED & PSA	310
	NED & PSA	vs SYS	77
	*Differential Expression is indicated by at least 2-fold change expression between mean of clinical status variable and comparison variable; also mean value >50 intensity units of a normalized data range and p < 0.001 calculated using a t-test

TABLE 3
Differentially expressed RNA transcripts identified from comparison
tests described in Table 2. Sequence listings are annotated with the
Affymetrix Human Exon 1.0 ST probe selection region ID, proximal
annotated gene from RefSeq, and overlap with coding sequence (CDS).

SEQ
ID		Gene
No	Affy. ID	Symbol	CDS	RNA Sequence

1	3509278	—	NO	ctggtccctctcctgatagagtttcaggtttgccctgatgatctagatgaagcaaagtgtggtgacacttcgctgaatgctctgtcagtgtgcctagaaatagag
				tctctatcagggccgtttgcttcctatcacactc
2	2750440	—	NO	ggcatgatctaggctaactccctggc
3	3498665	—	NO	tgggcaagagcttttgtatgtttccag
4	3159532	—	NO	cccaacacggtgcagccgatttatttatttttccctcagcatttttaggtggattgactgggatgctttattcaactcagggacgcaccacgaatatgttttttg
5	3521600	UGCGL2	YES	tggcgccagcgaaagccacgaacgtg
6	3820597	—	NO	gctgggcgcagcgttctgaggggatgtggggtctgggaggtgtctcgaggtgagagctccaagtcacgg
7	3955349	—	NO	gtggcgcaatattgcaatacagctcactgctacagccccaggcttaagtgatcttcttgcctcagtctcccgagtagctggaaccacaatctcataccaccac
				gccccacgcctggtaaatttttaaatgtttttgtaaagacagggtactgctgtgttgcccaggctggtctctaattcctagtctcaagcgatccttccgctttggcc
				tcccaaagcactgggattacaggtgtgagccactgtgcccagccctgctctaggttttcatttggatttgctgcctagtggaaggcacaggatggggcagtg
				ccttctgccagtgagggaggctccaggtagatgtcattgctgaactggagctcccctgg
8	3204523	PIGO	YES	tgcttcctcttctacgctggcattgccctcttcaccagtggcttcctgctcacccgtttggagctcaccaaccatagcagctgccaagagcccccaggccctg
				ggtccctgccatgggggagccaagggaaacctggggcctgctggatggcttcccgattttcgcgggttgtgttggtgctgatagatgctctgcgatttgactt
				cgcccagccccagcattcacacgtgcctagagagcctcctgtctccctacccttcctgggcaaactaagctccttgcagaggatcctggagattcagcccca
				ccatgcccggctctaccgatctcaggtt
9	3373899	SLC43A1	NO	agccatggccgtagatttataaataccaagagaagttctatttttgtaaagactgcaaaaaggaggaaaaaaaaccttcaaaaacgccccctaagtcaacgct
				ccattgactgaagacagtccctatcctagaggggttgagccttcttcctccttgggttggaggagaccagggtgcctcttatctccttctagcggtctgcctcct
				ggtacctcttggggggatcggcaaacaggctacccctgaggtcccatgtgccatgagtgtgcacacatgcatgtgtctgtgtatgtgtgaatgtgagagaga
				cacagccctcctttc
10	3707645	RABEP1	YES	atggcgcagccgggcccggcttccc
11	3860354	LOC100127980	NO	ttcagattcacgagggtaatccagatgaaggtatatcattgtacctggcccgcatcactcagtaactgtcacctttgatttattgatttacttgagatggagtttggt
				tctgtccccgaggccggagtgcaatggcgtgatctctgctcactacaacctctgcctcccaggttcagagtgattctcctgcctcagcctctttagctgggatt
				acaggcacccaccaacatgcccagctaatttttgtatttttagtagagaggagctttcaccataatggccaggctggtcttgaacctcaaatgatctgcccacct
				tggcctcccaaagtgctaggattacaggctggagctacagagcccagcctgtcaccttgatttaaatgaatgcagctttcttggtgtcttgatgtttgtgaatttct
				gtggagtttgatactgctccttttgctgcttgtttttccagagtccccttatcacttgacgtgctgttata
12	2406772	MRPS15	NO	tgtcgtgacagcctctctttggggccagcttctgcttttgcccccatctttgcagtacagggggtaaattaaacaagaggatgcctgaatgaacgatatcctgg
				gttcttgagagacaagtgggagctgataattctgaaaattcattagtcaaagcatggagataaaggtggcagcaggaaggggagaggcaaggagtagacc
				cgtgacagttttagaatcttatttgtgccaaaatactttactgcattggcttggacctctaatacaatgttgaattgttaaccatgatagcactgtatcctggtctaatt
				cctgaattgaatggctagtcttaccattaagaatgctatttgcggccaggc
13	3881324	HM13	YES	ttatgaatttgacaccaaggacctggtgtgcctgggcctgagcagcatcgttggcgtctggtacctgctgag
14	3271321	—	NO	aggagcaggtcgtcaagtccaccaggatggaatgctcagtaggagaaattgcgctgtggggccatttgaggcgcctgtccatgcgggtccgtcctggccc
				ttctgaa
15	3316374	—	NO	aggcattacgccagctcccggatgcctcagcctcgtgaattcggggtaggacgctcagggcccatggtcagcacagcgggtgggtgggtttcagcgtggt
				cacttctccaggggtgcataattgagcagcttctcgatcaggtccacgtg
16	3333695	—	NO	gttgaggagcttgatgctgcagtgagattgtgccactgcactccagcatgggtgacatagcaagactgcctcagggggaaaaaaaaaaaaaaacaccaaa
				aaaaaaggtatatggaccctagttttggccaggctg
17	3930855	—	NO	gtggctcactgtagcgtcagtctcc
18	2945934	CMAH	NO	ggacgattcgtttctatttgacccaagactgatgctgcgtggtgaaggagaggaactgcgttccaggcagaggaagtccagatgcgcaagagcagagatg
				ggagggacagcacagtggcttctcagaattgaatatggtgttagacttctaaaagagctgtggtagagggagaaaactgtcaaaggaaatcagtaactgtta
				aaggaaaataccttaaacgtcctgttttcaggctgactaatgccttaggggagcaaatgagcaaca
19	2581405	—	NO	ttggtatgtagggttcgtatgaatgaaacgtgactaccagggcagataatgaaaggctttcaatcccagagtaagagatatagggccaggc
20	2465840	—	NO	atgtggcacaatttacgaaaaccaaagagaggctatgctgagtccctacaccaccaagaccgtgatgttctgcccactcgcctcctgatggcctgtggggat
				agaccagcttccagatttcacacagatgggctgtatggaggaggc
21	3431367	—	NO	cgatctctcatggtgggctcaagtgatcctcccatctcagcctcccaagcacctgggactacaggtgcacatcaacacacccggataatt
22	3458114	NACA	NO	gggccactgttcctcaagcatctaaagggcttccagcaaagaaaggccccacagctctgaaagaagtacttgttgccccagctccagaaagcacgccaat
				catcacagctcccactcggaaaggtccacagaccaaaaagagttctgctacttcacctcctatatgcccagatccctcagctaagaatgg
23	3875254	—	NO	ttctccctcagaccaagttaaactgtttttttcccaagagctaggaatcatatctgatcacactgggacttcccttcactgtcagtctaagagtttgcatttttgaggt
				ttaggaaaagggaaaaaaaaggaagaaagaaagaaattgtatctgagaacaaagaagctgccacatggtccctcggtatca
24	2515646	ITGA6	YES	tgtgctcaccgatatgaaaaaaggcagcatgttaatacgaagcaggaatcccgagacatctttgggcggtgttatgtcctgagtcagaatctcaggattgaag
				acgatatggatg
25	3202904	—	NO	tgagggcgttggaccacacacccttgaaaaaggcctcgccccgctcatctctgaagatcttcctccaacagtcgacggtgcccgtgtacatgatgtcagctc
				ctttgcgccgggactgcatcatcgtccgccgccgcactgtgtcgaagggttag
26	2768304	NFXL1	YES	ctgtccaccttgtgatcaaaactgtggacggactttag
27	3736631	—	NO	aaagcggtcactggccatatgatgcggagatggttttatctgaggcctgagaaccaacagatgtgcctgcgccctggcctgtgcagctgtgggcagatgtg
				tccccaggggcctgccctcactcgtgaccatgcaataccctgcaacataaacattttcttttccaaggatctgcaggggtggacatgatgctccaggcacag
				agtaggaagaaaagggggtgacctggggttcccagcaaacaggtccacctcatgctcactgcgtt
28	2787529	INPP4B	YES	tgtgccctggtatgtgaatgtacagccccggaaagtgtgagcggaaaagataacttacct
29	2980188	—	NO	tttccccacaaattgctgatgtacc
30	3273235	—	NO	caatattcactgtgaggtcaagctcctagaggtaaaaactcaaaactgtggcagccctcccccgtgactgggtccctctgaagtttctaactctcagagttgtc
				catactgggcatctagcgattcat
31	3402918	USP5	YES	gaggaaaagatcaagtgcctggccacagagaaggtgaagtacacccagcgagttgactacatcatgcag
32	3529227	—	NO	cgaagtgggtctccaaattccgcgcccaccccaccgcccgagaagcccactacgcatgcgtccgcaccccaccggcgccccttcctattgagcatgcgc
				gggagccccacctatttctctctaccgtttcctccccctacctggtaccccatccctagctcagccattgcttttttttccacgaccctccgctgtttcttccgcga
				gcttcct
33	3839571	KLK2	NO	ggagggaatggctgtgtcccacaggaataacagcgggatgcttcc
34	2697538	CEP70	NO	gagactcgttgggtgatcatttcattgagatcaacctgaatgaccaggtgtaaagtgcaagagtaatatgctatgactga
35	2521076	—	NO	ggatccatgccagacaacgcacattctgcagacactggttactccagtggctccttactggaaacatataatatcagtgataagtgctgtgaagaaaataaaa
				caatgatgtgctggtatggatttttaacttttttatgtgatgaaccacagaatgatggttttaaatgtatgaaatacatagaattgcaacagaaaccagttatgaaat
				aatgaagatattaaatatgacatctatattttagtaaagcattagtgaggactgtaaatgatctttaaagaatttggcttaaatttaatctaaaattgctatcaggtatt
				tcacatcgctgtaatttttgcctgcattcgtaactgaagagataagtaaatgtcagaggttaagataaatctttttctttttttacctgtccatatttacaaacattctgc
				gttccgtacatagacgcctggataagaacccctgtgcaagaatgactttggtgctactttaaaaaaagtggttggggaagacctcataggaaatgacatcaat
				aatagattgcatgataacctatactagttcttactgttaccaatttaaattctaactgcttaaaagctaacacggtccttccctttttttgagcacctgatttgaagtac
				tttgagtaggcctcaagtgtcgtatgcaagta
36	2811029	—	NO	ctgagttctgatttggagcagcctgtcgcaataccaaatcacctttgaataaacttatcctctcagcttttattgttcagaattgatttcgaggatagaaattccattt
				ccttgtcatatatacctgagccgttgcatcaaattgtcaga
37	2735920	—	NO	gggtgtagcgcaccaagcatgagctgaa
38	3843767	ZNF135	NO	aataacctagcatggggcggcactaaatggctgcaggaaagccgagtcttcttccacatccggcggctcccctcggatgcgagcgctggcccagggtgt
				gtttacagaggtgagggcttcccgtggacccttctcgttgggagcgcttagcctcaggagcggattcagggcacaggcagaggacgtccacaaacacca
				caggaagccgccacccaggggcgtggaaaggcccaatgcctcgtctgggattcacggccggcaaagcggcccctccggaacgggacagcacagcg
				gctcacctctgcgcctctgggggtgcggggggagcctcgccctccacgctctctgggggaccgcccgccctagcccccgcctgggcttcgcgggtgga
				cggttgggggccccgggcgccccccagcgcgtagcttttctccttctcgtgggtcttctggtgctcggctagggccaggctgaagtggaaggtcttccagc
				agccctgacaggcgtagcgcttccggccgccatggctgctgtggtgctccatcaggtgcgagagccacgcgaaggcctccccgcactcgccgcaggca
				tagggcttcccgcgggacaagcccggctcgtcagccccagggccctgcccggcctccagccctgcgctgtcgccggagctagagacgccctcgaggct
				ctgcccgtccccatcctcggggtgcggcctcttggttcccagtttcgccgtgcccctgtccggggcaggctgctggatgacggactgcctctgcgatccggt
				ggcagagtcggactccgcgtcctgggggtcctgcgggtccggggccttcccaggctgctcttcctcctcctcagtggtgcccgacgggggatcggcaag
				ggcgtccccagggggcgcctccgtaggcagctcaggcagcacccccgcgggggcggcctcctcgcaggcgcacccagcgctctcctgccgcctccc
				gccttctggaacaaggtcagagccctagcgtgagcgccc
39	3895275	ProSAPiP1	NO	tgggcactcggcattttgacacatgtcctgtcaaaaggccagagtccccagtgtcccctcccctccatctctcttccccatagaccccataaccccagaccaa
				agaggttctctaagcagctgtgaccaggttcctccctccccacctgccctcctagctccagcactgcccccgtggcagcccacttggacccccctaaaagg
				agggaataggaggagggcagggtgagtgggggcaatcctaggtggtgggggagtcatgctccctttctcggcacccccttgttggagatggaggcagca
				gacgtgcagtgccataaggtgccccagtccttctggaggcctgggctgctactgttggccaccctgtgtctagtgatgctctctgtgctcacctcctaggccat
				ggagcctgagggggcctgcaccaggtttgctgaaactgacagagcctgggctccagacctctctccctcctacagtgctctccctccctgggcagattggc
				aggacaagtgggagcagatggcctgcctttggctgagagggctacctgcccagcccctcccccaacaagatctcttggactcaggcctcagagcctggc
				ctggttgtgagtgtgtgtccctgtgtgtgtgttgcgggaggggaggactggggctggaagtccagcacccagggaagatctgtcctcctgttcttgggaagc
				gttgcctgacggcttctcggctctaccctcacccttctggccaggatcccgcagggcaacagccccatctgcttggctgaccccacacccaggaccactgt
				ccggctctaacacagctattaagtgctacctgcctctcaggcactctcctcgcccagtttctgaggtcagacgagtgtctgcgatgtcttcccgcactctattcc
				cccagcctctttctgctttcatgctcagcacatcatcttcctaggcagtctcttccccaaagtctcaccttttcttccaatagaaaattccgcttgacctttggtgcac
40	4031098	CYorf15B	NO	tcacttaacatagtgccagggcatgcaattttgtttcttactctctggatgtgggatatgcgagtgtgtgtgtgtgtgtgtgtgtgtgtgtattaagctttctgtttctg
				atgaaattttcatatgaaatttactggagataagattaaattagtggaaaaacaagataattttgctttctatgtagtggtcaccaagttaaagaattgtgccagtta
				ttaggcaagataggctttgagatttagggacagttaaattttacaccaacttagtgaacatgagacttctacctagtgttacatttcatttttaaataagcaatttaaa
				aattggtaaatgatttgtttactttgattatattctggtataattttctgacaaaattatctgtgtcttggtcagcattgttgctagaatatgtattcagattttgtctgtcca
				taattgagaacacagaaaaaatctaatttgactatacccatttacccccatggaaatgaaactatattctatgaatgaaaaatgattttaataatgtggtgtattaca
				ttttcttcattcaagtaatgtaggccctgagtagagcatgttatgaatatttagttccttagtgttttctcattcaagcctctcatattgaatgagtctagggtttggag
				agatgtttcacacagcatgtctcttcagtgcaagctgacagatatcagtgcacaattaaagaaacttaattgcacctttcaacttggagtataaattttgtatgtatc
				tatgtatatctatgtgtgtattttgtggtttaaggcttatttacataatatgtgacattttacctcagaaattcagtgactgaatttcacagctgcttcccatgcatcttta
				ttatctatgtttctgaaaaactcaaatactaactaatctcttttcttcccttagctgttcctttcctgtggttttaaaaaagtgaccagaaactaggtctctattttcattg
				ctttgctgcatattcttttaacctgcttttatc
41	2927637	KIAA1244	YES	gtcccacaggatttcgggaatcaag
42	3839575	KLK2	YES	ttctgaagcatcaaagccttagaccagatgaagactccagccatgacctca
43	2566620	TSGA10	NO	atccattgatggtttgatagtgggctgggaaggaaagctgtgttcctccacattaggcagcaaa
44	2959903	LOC728052	NO	tcatttatttgacagtgcatgtctgcaatgccgtgctcatcaatgat
45	3100926	—	YES	agtaacagctatccaccaatgtcaatccatac
46	3853655	—	NO	gcaggcaatatctccgcacctttaat
47	3947544	—	NO	ctgctggaacgacaccaactctttgcctcccatccttggttggatatgatttgaaatttggtaatgtgtctctacttgaaacagatgcactgtttggatgttttcagg
				tcggtgatctacttgtccagtttgatcgctaccagaag
48	2466070	ZNF692	NO	ggattagtccgctccactcactgtcagcattaagtgggggtgcccaagacggggtggatggggggcgccctccagacctctgaccacggcctcaccgcc
				actcgacccaactatgaagagcgcccccagctgcacgccaggacacgacctttccttcccctagaaaccagtaaaggccgctgccctattcaagatgaaat
				gtgtggaccgcccccagcccagttgaaatttcccgtgaaagtctctcgccccttccccacagctccacttcagtggactggagggcgcaggcctttgttctg
				actgcttctgtctgcctgcctcccacccgacgacactcacatggtagcgctgagcttcaacaccctgta
49	3065818	RELN	YES	ttcgataggtttgaggggaagctcagccctctgtggtacaagataacaggtgcccaggttggaactggctgtggaacacttaacgatggcaaatctctctact
				tcaatggccctg
50	3332183	STX3	NO	ctgatttcactccagactggtgtggccacccttgtcttcagatgagaat
51	3681410	PARN	YES	ctgtcaataccagcaaatatgcagaaagctatcggatccaaacctatgctgaatatatggggagaaaacaggaagagaagcagatcaaaagaaagtggac
				tgaagatagctggaaggaggctgacagcaaacggttaaacccccagtgcataccctacaccctgcagaatcactattaccg
52	3873342	—	NO	gccacaggagggtttaaacacagcagtaatgagactttatttctgctgggaaaacattgccgttattgccc
53	2572055	—	NO	gtgcctgagagaaaacggcctaatcgaaaacgtccgcggcatacatccattcttaaaacttgagtggctgcttttctgggtggaaaagagcggtatcagaca
				gggtgagcagtcggggaacggatgaacaaagacttgcaccgtggccctgatgcctttgttccgagttctattcagttgtacttgtgcgttgttacaggacttta
				gaatgcagccctgccccccaacccccacctcccagggccgacctgtgctcctaggaaggcaaacctc
54	3434549	MLEC	NO	tggcacctcttgcatccaggcagtcttgtgagatgggggcacatagcactggggaaagcagaactccattctcacctctattttgagcttcagtgctttatttca
				gtatgaggaaaaacaacaacaaactgaagtgcgctttccgtcctttcaaaggacaactgtcgggaagggagagccgagttgcgaggtaggaggggagca
				ctggcagggagagacattcttgactcctctcttccctggtgtgttgtgatccagggaatgaaaagaaatttgaccctggattggttctctccttggacttaagga
				atcttaccttttccttccacaaagttctcccaggcaaggaccagctgcccattctgagcccagggcagcctcttcaaccattattgg
55	4007482	—	NO	tccaagcaggtcttcgtagtagagaacgaaccagccctcgatcaccaggtgaatgaacccacacactgcaaaccagcacagggacagtcgccgccaagt
				ccccaatgggacaaccgcagcacgacctgacaacagccatgtggtcacgactaagacccctgtgacagagaagaggccagccagtatatgccaggtgg
				ggcggtcattaggtacaaagttgtc
56	2751391	CLCN3	NO	cccgagttagagcatggattcagttttagtcttaagggggaagtgagattggagatttttatttttaattttgggcagaagcaggttgactctagggatctccaga
				gcgagaggatttaacttcatgttgctcccgtgtttgaaggaggacaataaaagtcccaccgggcaaaattttcgtaacctctgcggtagaaaacgtcaggtat
				cttttaaatcgcgatagttttcgctgtgtcaggctttcttcggtggagctccgagggtagctaggttctaggtttgaaacagatgcagaatccaaaggcagcgc
				aaaaaacagccaccgattttgctatgtctctga
57	2871645	—	NO	ctctgtggggttcggttccactttgtagttcgggtttgtaatgtaaagaataatgggaaactggtctaattatgagagttaagagagtagaggcctgtagttg
58	3629576	PARP16	NO	ttagccataatagggcccggtacgatttgggagtgacatttctgtaaagaagaggaaaaatcatttttctataatttgtaaagttgtgaaagagccactaccaca
				gtttttacattgattattggaacatttc
59	2545930	IFT172	YES	tggtggctacaacattggcaccgtcagccatgagagccgtgtggattggctggaacttaatgagactggacacaagctcctcttcag
60	2569734	—	NO	ttcccttggctttggacatgtgagggaagtaggtatccgctgcctggggaaagtcaacaggacccctcctccccgtacctcttggtatacaaagctgagcgg
				tg
61	2832639	PCDHGA10	YES	ttactttgaagtttgcggcatgatggtggaaagtgtaaatgctaaaacactgatgagtagaatttg
62	3113343	—	NO	ggctgattgaccttgactggcctcatgtatgtgtctcaaagttggctggggctgtcggctgaaattccttagttctactccacatggcctttccccatggccagc
				ccaggctgagatctgagattgaagagggtgagaacagaaagtacaagatcttcttttgacttgaaagctagcccagaatcgagggaaataaaccccaccttt
				tgatggaaggagcttcaaagaatttgtagtcatttccaatccacgaagagtaggtacccactatttgttgaataaagccctattgaaagctttttagctatccaga
				tgcaaattactggccaacctttgggtagaattataaaattctgcccaaaattctaccaaattactggtacttgtaaaattctaccaaataactggccaacttttggg
				tagaattgtaaaaattaagttgtaaataaagcctattgcctaacaggaacttcaaagtcagagaatcctaaaatgattgtgctacacagggccacatagagcac
				agctttgtctttttttttttgagatggagtctcgctctgtcccccaggctgaagtgcagtggcgcaatctttgctcaaggcaacttctacttcccaagttcaagcaat
				tcttctgtttgagcctcctgagtagtgggactgcaggcatgtgccactatgccccattatgtatttttagtagagatgagatttcaccagattggccaggctggtc
				tcgaactcctgacctcaaatgatctgcctgcctcggcctcccaaagtgttgggattataggcatgagccaccatgcccgcccgcttcgtcttttcactggacta
				atgaagatacaggtgtggaatggtttcacagcatgcccaacctcatgaggcttgttgggtcagagcttgtgccagatgccagtcttctgccttccagtcttata
				gttgttacgctatagccttctgcagtggatggtaacgtggccaaaataagcctttggttttggagtattcgtaaaatg
63	3875673	—	NO	gggaactaacgccttccagaacagaaatatgtggtccgatgagtattgaatgcaacttaaaatctagttggaatgtgatggataagaagagacccaaagtcat
				caacaagccttctcatgaactttcagtcattaaccttcctatatagtaaggacagaaatgatgatttaagccatcttaggcaaggcagtgctaacaatatgctttt
				gtaaagtcaccatccggtg
64	3959071	—	NO	ttctctaattctaggcctgccgtttttctctgtgagtggacctgatctccttttgctttggctcccagagttccctattcgcttctccttgtcccctgagtcctgctctcc
				ctcctctggataaccccttccagcccttcacttctccctcctgttatttgctggaatggctaattggctgacccccccacccagtccccatgggagaccccctcc
				agcaccagaagaggcagactaacattttctttggtagcagaatgtaaaattgtaaaatgtgaaagataggagagaaacatcattaactgttctgttatttattaac
				attttaatttatagaattatagacttaacagcaaaaattcaaacactgagggtcatcggtgaaaata
65	2864793	—	NO	gcctattggcttcaagttgtttacgctttggtaggttttggcttgttccctcaaaggatcccttcttcatgtcctcccatgatgttgcaggcaagggtctcttgttatat
				gtggtactaactcgggcccacctggtcataatttc
66	2976430	—	NO	gctcctacagtaacactcaatcaattcaccccactccagtgttcttcctgcaacatcactgatttagatggcccactctg
67	3862771	—	NO	gggaatctattaatagtggaggaagtatttagtgggtggga
68	3192159	BAT2L	NO	tggatatatggcattgacccgcttgctttgatacgaaacaaaaaagcagacgactccttcatcccatctgctcctaccgtgactgtgga
69	3062031	—	NO	gggtttgtcatgctacgctgtgccattcatgtgtttttttgctcatgctgttccttgtgcctggaaattctccccctaattcccctgagcagtggatgcagtggatac
				cctccccagatcccccccaacttccctgagtgttggctaccaaaagctctgagtgcacccagggagctaagtcctcctgcccacaggcaataatggactga
				cacggggtagacttaaagaaataagaggcacatcaatcaattgaaatgtgtgggaccttacctggactctgaatta
70	2505555	PTPN18	YES	gagcagtacaggttcctgtaccacacggtggctcagatgttctgctccacactccagaatgc
71	2361309	—	NO	gagccggacttccttgtcccaccag
72	3569829	—	NO	gtactcgcctcctgcatggagcacgctcaggggtgg
73	2946327	—	NO	ttactgttgctgtccgtaaactggaacctctgttcactcaag
74	2751432	—	NO	ggaactcctcagaacttataatatgttgatattctttgattcccagatgaggggatgggtaataggatacatggttttccagacttgtttgaaaatgcaactattttt
				gggttgcagggaaggatatagtagaactcatgggaactggtgtttcttggaacatgctttggaaatgctgggttatgccctgttaactcttacatcattagttttta
				gcccaaaaggaaacagcaaataatgttttatatgagccacattttgcgttgattttcc
75	3907608	ZNF335	YES	ggacgtctacggaagtggagcacctccaccaagagccaagaggaagagggaccagaggaggaggacgatgatgacattgtagacgctggagccattg
				atgacctgga
76	2316543	—	NO	atgagacctcagacaaagccaccagga
77	2453070	C1orf116	NO	tgcgaccagtacagaccctgtcctggctgaacaagaagagacacatgctccacttgggagcctttgccaccacgcaactcagggctcaagatgaatggga
				gggagagatttgagtccaagcatacatttatattcagtgttgtgccattgagttcccatgtggatcattctgaaggtgatctccacaagagggtgtgtgtgtgtgt
				gtttggtgtgtgtgtggagggggggccgctggatacatcactgaagctattgatataacacaatgagtcactgttcagaattttgctcttgttagatgttttcttac
				attgggtagagtccagcc
78	3119603	RHPN1	NO	tccagctggcagcaagcaccgagcatgccctccccacccagaggacctccgggcaatgcctgtcccgcctcatgctggaggctgcctcgggcacctgcc
				tgcccattaaagactggtcagacctgt
79	3908801	STAU1	YES	cactgcagaaggaacgggcaccaacaagaaggtggccaagcgcaatgcagccgagaacatgctggagatccttggtttcaaagtcccgcaggcgcag
				cccaccaaacccgcactcaagtcagagga
80	2525664	—	NO	gaagctgttttaatggaggccgagagttggacaattttgtgttatggagaattctgggaagaaggaaagacccggatgggactgtttattaaggcttatgactg
				gactggagata
81	2395926	CLSTN1	YES	tacgggaaagaacatcaatataagctgaccgtcactgcctatgactgtgggaagaaaagagccacagaagatgttttggtgaagatcagcattaagcccac
				ctgca
82	2571145	ANAPC1	YES	ctcaaaagtgtttattacatctgacctatgtgggcaaaagttcctgtgctttttagtagagtcccagctcca
83	2836006	—	NO	ggatgtacactgatttggccctttaaatgacattataccaagaagttggtataagggagtaggagatgagaaaactttttgaaaaatcatttggtgcatgctaag
				gtagcttgtaggacatgtggttttaaaaaattcatggattttgaagaaggatagggtggaagtaaaatttagctgatagcatagggatcatttgtgatttatataga
				aaataattatatttttgagtgagaagcatcagacttaaatttttttcttctattttggttattaccaaaaggaacagagaaactctcagaattctttgaatcatagaatg
				ttagtgctggaaaggactaggaagtgacttgtacaaccccttcattttacaaaggatcagagagaattggttagtagagtcccaaatctgcttttagaagtaata
				tggtgatcatcagtttagattcactgtaggaagggcagccctgttaaagtttgtcaggagaaaaagggaaggtatcactttttgtatgttcacccagttgcttctg
				tagttttcatacccctgttttctcaattttcttagaactgtctttaatggcccagctctaccagggcttgttgtctaaggacattaacttgtgctcccctcagggatgg
				gtttactactagctgtcagaaagctattgggtatcctaatgtgttaatagctgaaactcagctgtaatttctcctaaatacttcagcattttgcattctgtacattgtgg
				tgctttttccaccttgtattgttgtaactgtaagctcctagggggcagcaatttggtcttaggcgtgtaccctgtttagtgcctggcaatgccatgtttatatcaagg
				tcttaatattacttttgagttatttctcccactcttcatggaagtgatgctccagccttgctaaaacactgagggtcctcccgataagccaggcattgtgattccttg
				gcttcaagtgccttctgtcttccccgaaggtccactgagatctacaatcccccctt
84	2517773	—	NO	tagcggagaatgacctacctacttgattaatgatgtctgcatgggcttactaagagggtgtggggaatggtggcaggggtaactatcatcgagaatataggg
				caatgggtatattctaactttgcataactttgctagattatatatatctttactcacaataagcaaagttgaacaacttaaaattgattccctgttttctgttttcactatc
				caactaggatgaactcttaagttcatacatatactttaaaatgggaacaaacatagcctgtcatgtctttatttaggctaagtgcatatgtatgtataagtaatgtgt
				atatccttcacttattaatagtgccttcatgaattcaaagacccttgtcacatggtgctcaggaaaaaaaaagtgccaatattctttttttttttttctctaagaagtact
				agtttaggtaagtgaaattcaatagcatatcagtgctttaccttagtcactttttgtgttttgatcacccttagtcatcactggagagaagagtttgaattcatttgtgg
				ttttgctttagtggcaaacctccttacagggatgagttgccctccattctccttgccatatttggttaatctaggccatgacctttgaggggaaaaggcacagatt
				gcaacttttctttcctgcttttgtgaatcaggccatgttcacgcagggtccttgaaggtgacttgagtgaggaagctatataccgatgacttaccaatttttggtctt
				ataacattctctctctttttttttttttttttttgtagcatatggcttcctctactgtatgttggcatttgccacttttggggatttgactcctgcaggtattttt
				ttttttttcttttgggggagtgtgacggcagtggatatagtcttagatgatgtttttaatagttcaagtccattagtgtcttactctagagaaaacg
				aaagactcactgtgtgagttttcttgccctctggttttcagaattctgtgtagtttctcaacat
85	3064957	—	NO	aaatccacagccacatctttgaatg
86	3239181	KIAA1217	YES	tcattctcaccgcagagtcaaaatggccgagcaccccctc
87	3629017	CSNK1G1	NO	tcaccatctataaggtctcagagcagaggattattcatggtaataagtgggggtgtggtgcagccattccagtaacaccca
88	3709453	—	NO	ggtgggacttacaggtctcgctatagcaccagataaaatccatactacaccctatcattacctgggaatgagggtacaggagaaaacagtaaagcctcaaa
				aggaggaaattcgtaaagagtccttaaaaaccttaaatgatttccaaaaattattaggggacgttaattggataagacctactttaggaattcccacctaagcaa
				tgtctaaactgtttgctttgctgagatgggatccaaattcatgtagcaaaagaactctgatgcctgctgcagctgaagagttacaaatgattgaggaaaaaattc
				aaagtgctcaagtccgtagaagagatcctagtgttccattacagctcttagtgttccctactctccattctcctataggagtgattgttcaaaatgttgacttagtta
				aattgtcctttttaacgcacagtacgactagaactttctcaatttatttagatcaaatagctattcttataggccaaatacaactgagaatagtcagactcattggca
				ccgatcgagataaaaatgtagttcctttaaacaaagcacaggttcgacaagcctttattaattcgtcagaatggcagtcaaatctggctgattttgttggcagtat
				agatattcattaccctaaaactaaaatgtttcagttcctaaaaattgactacctaaattttacccaaaataactagttccattcctttggagggagccgtaactatctt
				ta
89	2732012	FAM47E	YES	ccttataagccaaagtgggtgaagatgaggtatggagcatggtatttgaaccccaagttgtggaaaaagcaaagagtagacgagcctctggttgaccctga
				ggtctcacata
90	2787588	—	NO	ggttgctgcccttgagcattttgcc
91	3630110	—	YES	atggagcacctgttcgtgtacctcc
92	3738711	—	NO	gtagctaaacatatgcgtggggataaaaatcgggtggacaaggccagatacatgaagacatgctccactctcatctgtgaa
93	3675240	—	NO	cccggactgatgtgatttctttgacaattacaaaaaacaaaaaacaaacaaacaaaaaaacgcaaagcaatagcagggaaaggacagtttgagaagacct
				gcaaggcctgccaggcggctcgcttgtgcagacacaaccgggacggctttgaggggacgtgcacacccaag
94	3458922	CTDSP2	YES	gggacctgagaaagaccctcatcctgg
95	2694337	—	NO	gaggaagacttgtgcgcccggcccacacgaaccatagagccgatctccggg
96	2990414	—	NO	ccctccacacgtgttcagttaaagtgtgaggaataccctccccagacaaacatcacagatttccgaaatcaaacacgctccagcaagtgttctgcacacccc
				actg
97	3190328	—	NO	cttctcagttgggtcaagtccattgacctttctgttacagcttgagttttgtgtcttacgtagaaaaggtgcccctgctctcactttctgcacagctatcaggtccag
				ctcatagcagttcttcta
98	3745435	MYH3	YES	ctgagattgcaggatctggtggataaactgcaagtgaaagtcaagtcctacaagaggcaggcgga
99	3110076	LOC100134128	NO	gtaaaagcgcggcaccgacaccagctgtgtgcagcagtggcggcggcggccgaaggagaaatagaacagcgcaggcaaaagaagaaaggcgcgg
				gctgg
100	3471539	—	NO	cacgggtccgctagctttaagtacaacaggatttccgtgttcaaaagactatactaagtgcttaatcaaatcccgtcacactaaagccaaatttagttctctagg
				aatcggagtctgcgtata
101	3918710	SON	YES	cagagcagcctgtagacgtaccatcggagattgcagattcatccatgacaagaccgcaggagttgccggagctgcctaagaccacagcgttggagctgc
				aggagtcgtcggtggcctcagcgatggagttgccggggccacctgcgacctccatgccggagttgcaggggccccctgtgactccagtgctggagttac
				ctgggccctctgctaccccggtgccagagttgccagggcccctttctaccccagtgcctgagttgccagggccccctgcgacagcagtgcctgagttgcca
				gggccctctgtgacaccagtgccacagttgtcgcaggaattgccagggcttccagcaccatccatggggttggagccaccacaggaggtaccagagcca
				cctgtgatggcacaggagttgccagggctgcctttggtgacagcagcagtagagttgccagagcagcctgcggtaacagtagcaatggagttgaccgaac
				aacctgtgacgacgacagagttggagcagcctgtggggatgacaacggtggaacatcctgggcatcctgaggtgacaacggcaacagggttgctgggg
				cagcctgaggcaacgatggtgctggagttgccaggacagccagtggcaacgacagcgctggagttgccggggcagccttcggtgactggggtgccag
				agttgccagggctgccttcggcaactagggcactggagttgtcggggcagcctgtggcaactggggcactagagttgcctgggccgctcatggcagctg
				gggcactggagttctcggggcagtctggggcagctggagcactggagcttttggggcagcctctggcaacaggggtgctggagttgccagggcagcct
				ggggcgccagagttgcctgggcagcctgtggcaactgtggcgctggagatctctgttcagtctgtggtgacaacatc
102	2792431	TMEM192	YES	tccttggatatcacccagagtattgaagacgacccacttctggatgcccagcttctcccacaccactcattacaagctcactttagaccccgattccatcctctt
				cctacagtcatcatagtgaatcttc
103	3828963	DPY19L3	YES	gaagtggagcgagaaatctcattcagaacagagtgtggcctgtattactcctactacaagcagatgctgcaggctccaaccctcgtgcaa
104	3874927	CDS2	YES	gttcattgtccccatatcttgtgtgatctgtaatgacatcatggcctatatgtttggctttttctttggtcggaccccactcatc
105	3012468	AKAP9	YES	ctggggtcagggaatttatcttacacacagtcagggatttgacatagcatcagaaggccgaggag
106	3541309	PLEKHH1	YES	gatgtcatccggaaacctcaaggccaagtggatctgaactcccgctgccaaattgttcgaggggagggttcacagacgtttcag
107	3543492	PSEN1	YES	gcaagtgacaacagcctttgcggtccttagacagcttggcctggag
108	3878896	—	NO	aacgtgctcagggagaatcagctggtttct
109	2669445	—	NO	atggctaaaactccaatagacagcatgtagtgcttgggtgacagactttgggacaatcacagccactacaaagtgaaaggggagaatccagaaagtacag
				agccagaaagggagagccccaaattctatgtaaaaactgcccaaatctttggctgaccactgaactatgcatgcatggggcagacgctaagcaacctagct
				aaggataaaataactaagccgagaattgaggtagtgcctc
110	3953763	PI4KA	YES	gagcaacctggacataactgtcggctctcggcaacaagccacccaaggctggatcaacacataccccctgtccagcggcatgtccaccatct
111	3529048	—	NO	gcccagtacctctccaagggttgtatatccggtgggggtggagggatcggcagaggtggtgtctcagccctttcgttcaaggagcgggttgatggtggtgg
				tgtaggaattgctgggtcttggaaactaggggcaccaggtactgcgttgtcccgaaaccactttagttgcccatgcttcaaggcatagcgtgtgtcaccaaac
				cactgaatgatctcaggccgaggtaaaccagtgatctgttctaacttttggtaatcctcacgccgtgcccactggcactgtaaaaaaaaggatttaaggatagc
				cagctgctctttggttttgcgcttggtctttcgctggcgttgcatatctggggaaaggtactctgtggggccaactctacctggtactga
112	3691111	—	NO	ttgacgtggcttatcaacctttgtctcttacgtgctctttgttccggccatcgtcttgtttaacaaa
113	3845902	TIMM13	NO	gggtccgcatgtacgtactgcctgcccggggcttaggagggtggcaccggtgctgggacacacgggactgtgtcctcgccaccccccgccctgccccct
				gccagccagtgcagcttggatctcgggggtgtggggccctgtgccttcctgaagtgctggcagcccagtggcacctccttcaggcctttggggtattcccct
				agtgtgcccaagtcagcctcatattctgggcggacagcttgtctggacttcggagttgggggtggtcagacaccacaggagctgtcacctcctgcggatgg
				gcaaataaatt
114	4009521	PHF8	YES	gaccctgctttgaaatctcgacccaagaaaaagaagaattcagatgatgctccatggagtcc
115	3817782	—	NO	catgcccggcccagtaattaggtttttttttaaaaagccccaaaccttaattttatttgcccctcatttcacggagctcccagcgtagtggggagaagctggccc
				agagaaccccacgtcctgcacagtgagggccagcccttggggaccccatgtcctgcacggcgggggccaggccctggggccacgtgtgttcccccccc
				acccctattttctgccgcgtgctcgttctgctgcacgtggctgtcacttgaatgggaatttaaaaatataacttaatgcacactgacttcccttgattggtgcaatta
				attatttgaaaagaaaaatatcacagtgttcttaaggactggcatttttccaagctgtgtcagttttgattgatgtctgacgccgtggctggcttctgaaagcctca
				ccagttctgatggcttattggcgacttcagtgtatccagcaatctctgctcatctttctgggggaatatataatgatcagcaggcctgagaactcctacaaatca
				gagataagaaaacaaatggcccgatgaattcggcgtgaggggcttgagcagacgcgttacgaaggagctgcaggaacgaaagccatggttcagtgccc
				agcatcggtagaagtcagaggcagccagctgggagacaccgccagccccaggacggccacgtcagaacaccgccaccagatgccagtgaggaggg
				cgcagctgcacgctgctcccagccggggtggatgcagggcggtgccatggccatggaaaaccgttcggcattttcttggaaacggaagcatgtaccctgt
				gccccagcgatgccactctgtgcatatttactcaggagaaatgaaaacatatgtctccagaaagattggtacataagtgttcttagcagttttcttcacgagagc
				cccaaactggaaacagcccgcacgtccatcaacaggaggatagataaataaataaccatagatccacgcgcaaccgagtactgtttagaaatgaaaagga
				gcg
116	3948736	—	NO	cgttgatcccacctccttgatctggtttctaagacctcatacaaactgggcccgttagtctttgctccctgatactatctgataccatctggtctcac
117	3104724	ZBTB10	NO	ctggtcggacggaaacgctccgccggctttattgtcgcttcgttatgtggcggagccgagcagtttagcgtgcctctcaccctcagcgcctgcgaagccggc
118	3364565	PLEKHA7	NO	actggcctgtgctacttattaccgggcttgtaatagcggttcttgtctccatagcctgttgagtgttcccagatgtgactcacctttctgctgccctatcatgcag
				gcctactga
119	3540221	—	NO	atgaggccggaaagatggcgaatttgcagggctgg
120	3458075	—	NO	ccaaattttagttgtgaggaaacagacataccaagtattctttttagcaatgagcattagttctgtttttcttaacagtgaggcaaactatgtatatttacattttgtag
				aatatttcctccaaaattggtttctgcatactttttgtttttgctatcactgtttgggcttagagtagtatccttgaggctcgtctcatcttttttatttgttttgtttttttgttt
				gtttggttttgttctttgagactgctgcagtacaatggagcgatcccggc
121	3773290	—	NO	caggctcatcattccttgttggatttcttcctggacttatttaaaagttgttatagctattatgaatgagcttttttaaaaattgtaattcctaactatattactggtgtag
				aagaaaactacagagctggtatccagctactttattgatttcttactgtttctattggcttttatttttcattagtagaggttgagaatttcagtatttcattcccagatcc
				atatctcatttctttctcttgttttctttgcgttgctggagcctccaaaacagtctggggtaactgctatgctagcaggcctcctcatc
122	2835195	FLJ41603	NO	ttatcggtgtagcagagaggttcccaagactcttgactggtcctgggagtgggtgtgaccaagtcatagttctggaatgtgtgtaggcaaattcagaggctgtt
				ccagggaagaggggattttgatactgtgttaggtggggtgtgtgaggctgttggcagcaggtgaacagctactgctgtgttctcaggactagggaacaaag
				gggtatgcaaatcatagaggaaactctgggaaggcggtgataaggcctggtgggtggggaggttagggaatggcttgctttcctgtttctggttagaaggg
				gagccagggggaacccccagtggtttcaggtggcccctgaggtcctggaggcagccgtggatgtgatgcaattggctgtgggaccttagatgtaggaca
				caacttcagtgttcccatccagaaagacctcactcacagggttgtgctgagaatgacgtggggctaagcatgcagagctccctgtaaactgtgaagtgtgat
				acaaatgtaaatgacagcagtgatctcggggtggcccccggcatgctgccctcccccacgcccatgcctgtggcagcaaaccttgttcatcagtatagcttt
				ctttcctgtaacccaggatctaccttggggggcttctcaatactgcattctatgtagccagcctctttaacttggtaagtgagccaccccattctagaacctggaa
				attggagcccctcaaaaacagttcctgttcaaggaggactgacctgctggggcaatgttgggtgcagtgcagtccctgcttggggtggtcatgtctaggctgt
				tgctctgggcaaagataagagcaagattcacagaaatgggaaaatgtgaccaagtgtgatcttaacaactgacaaagtttgtaaccaacccaagttagaatg
				tgtgtcaaacaggaggtagtttagatatgcttccaagaacatgtctgtgttataaccatagtgcctaagcagtgagctctggtttttgaagggcttttaagaa
123	2988321	FOXK1	NO	aggctctccgggcaaatcagaaggccacgagagagagaggagcggggagagtggtgaggaggattcgtctctgactgatgaacctcgccgtgcctgtc
				tgtcacatccaagtctgtgccagctgctgggaggtcagactcctgccctgagaa
124	3632941	UBL7	NO	cccagcaagttgcagaggctactgcccttgggaggcactcatgaaggtgcctccatctctccatccccaatatacctgatggtcaactctc
125	3855574	—	NO	ggcagcaggggtcagattttcctcatggcctctccagcaggccagcccgggtttctcctggtggctgggagccaggagagcggctcccatgcagagtgct
				ggtttcacatttgtgggtggcccatccgttgaggccagtcacgtggccaggcccaggaccagatgggagaggaccgcacaagtgcagcgtgagctgtgg
				gaggtgtggctgaccacgcttagagagtgtggtgccaggaaagatctgatgtgtcaccattctatatctgtgatgggcagacgcaggcaggtcaaagggg
				ccctggggacttaccgagcccctgcctattggccaggcactgtgattgtcctcggtgccatgtgccatggaagccctctcagaggtcgaggggaggcagg
				tggagacagagcctctgtaggcctttcaagctgtagccccagagcccagaggcagccgaattcatgtgtgcagtcagagagcacttagtgggcactgtagt
				caatcagtgagcgcttactggacaccacaggcagcaagcatttactgagtacctctggcagttgatgcatacttcctgagtacctgttcatagcaggcttagct
				ctggatgtggggtggtgaggaatcccacaggctgaggggtggcctgggagctttccagggggcctgaagcaggaggggctgcctgagtgggtcagca
				gcccagcccagtgccctacgcagccctgcccacacccccaacccagcctctgtctccccagtcccatcccccacaccctggtccctcctactttgtgcctcg
				aggacactgccccgctgccctcctcacttcccagcgtctgctgtcccctccgctgctgctgcccggcaggattgctctgtgtctcatccacgtttgtccctgca
				gagttcctcgcctctccctggaaccgccagcctcatgccgcatctcagaggctttttttttctctcttttttttttttttgagatggagtctcactctgtcacccaggct
				agagtgc
126	2648215	—	NO	tttcgcagttgccaaaaatggtgccgtaaggctttcctggaattaagtagtcagaggtatttggttagcagatgctttgtaaaacctaatatattcccactatatttc
				ctttaaaaatcaagggggggttaacacctttagattgtcatgttttattgagaaaaatccacttctctgaaactccctattactg
127	2714009	—	NO	atctgaggccaaggataaattcatcaactgggtagccaccactatagaagaagccaaccacaatcaatgtcggctatgcgtccagctgccagaggccgcc
				aggaatgagctaccttgaagaatcgtccgtgacaacatttctgaatggctatgtcactatcaatggggccacaacaacaacacttgcaatccaacctgaactt
				cctatgaccaaaccaagcaatctatttatgcccaagtcaagtgaaaggtgaactccaccttcaccatgcatcaaaagccttggtatcctgcccaatatgcctgg
				aacggtatatattgggaacctgctgtgctggtggccggattccatatagctcc
128	3342827	—	NO	gagcaggcagttggcaaaccggaaag
129	3494235	LMO7	YES	ggaaagaagccgcaggatcagcttgttattgagaga
130	3816344	SF3A2	YES	ggagctacctggcacatacgcaggggaagaagc
131	2340361	DNAJC6	NO	cggcggcttcgcctcgcccggcgaagcttctctccggtggccgctccttcttttccctcctctttgcgtcatgtcgggcacttaatttttt
132	3557286	HOMEZ	YES	agagcagctggctatccttaaatccttttttttacagtgccagtgggcacggcgtgaggattaccaaaagttagaacagatcactggtttacctcggcctgaga
				tcattcagtggtttggtgacacacgctatgccttgaagcatgggcaactaaagtggtttcgggacaacgcagtacctg
133	3911399	—	NO	attttcctgcattcacgatggcctcc
134	2612381	EAF1	YES	cagcagtaaaatccaggcccgaatggaacagcagcccactcgtcctccacagacgtcacagccaccaccacctccaccacctatgccattcagagctcca
				acgaagcctccagttggacccaaaacttctcccttgaaagataacccctcacctgaacctcagttggatgacatcaaa
135	3354739	—	NO	tttgagaggttatttgtccatgggatgctcgtgttaaaacaaaaa
136	3434425	RNF10	YES	taatcgcaaacgtgaactttcctaccccaaaaatgaaagttttaacaaccagtcccgtcgctccagttcacagaaaagcaagacttttaacaagatgcctcctc
				aaaggggcggcggcagcagcaaactctttagctcttc
137	3734620	KCTD2	YES	aggaagcggagttttacaacatcgcgtcccttgtgcggctggttaaggaaaggatacg
138	3802333	LOC728606	NO	ttcagctacgttgtcccagcacttcactggttaaccttttatgtccaccatttgtggatttcacagctacttgtcaatggtgaatattgatcatcatcattatctactga
				gctgctaccatatcccagctactccttgcatgttgttcattattttctcaacactcagcatatttgcaatatgttatgtaatatcacagacaaggaaactgaacgca
				gaaatgttttatttcttgccaaacatcacatgaggatgaacaatgaaaccgatttgaaaccaggattgtctgattccaacatctctgggtctttttcactctgatatg
139	2896736	—	NO	aggatctagctctcttgctcaagctggagtgcagtggtatgatcaaaactcactacagcctgcaactagtgatcctcctgcctcagctatagctaaaactatag
140	3053930	—	NO	ttggcacactaactccacttctagacatctatcctaagataataatcaacatataaaaatgcacatacaaatattgactataagaataaaaaaatttcagcatttaa
				gctgtacaggtgaatgtttaaattatggtacacccatttgtgttatttattttaaaaaatttttttgaagtataactatgtagaaaactgtcctagcataatgttaagcat
				cgttcccaatgtgttt
141	3459700	—	NO	ctaaggtgagacaggtctgtgaatccggggtctctgtcacttggggaaaaaaaacgggcagaaaagctctgaagtttgaaacacataaggaaaatctgcta
				tctgtacccccaccctcccaaaatatagttgacgcccccgcgtgatgaagagtttatgggggtggaggcttggaggagatgtcactgcgcctgggagcttgt
				gtccgattccgggaggtggccgtgtccgagtgcgtggttgtacatttccgaaggtctcagtttctctcactttcagcccgcga
142	3223562	MEGF9	YES	gtctgccagttgcgatgccctcacag
143	3888086	ARFGEF2	YES	ggaaaggccttgacatggcaagacggtgtagtgtgacgtccatggagtccacagtgtcctcggggacccagacaactgttcaggatgaccctgagcaattt
				gaggtcatcaa
144	3378887	TMEM134	YES	ggattccagccgaacttccatccgcag
145	3280240	—	NO	acctttccctgaggttggataggcactgctccccttctctgtgcccctggctcccacatctaatgactcctggcacttacgacactctcattcaaattttctagcc
				atgcaccttaagccc
146	3379391	—	NO	ttttgtacatgcacttgcagtattgaggttaatca
147	2351210	FAM40A	YES	gcagcacccacctcaaaagccaaaacagactcaatcaacatcctagcggacgtcttgcctgaggagat
148	3758440	—	NO	gtttcactatcgagagtcggactgcttttggatttacgtggctttgtgggatgcggtatgaagatcgttgcattcaagtttaccgcctctacttcactgcagaatct
				gactgccgtcagatctgtatgac
149	2617213	ITGA9	YES	tattgggctggaaccatcaaagtgctgaaccttacggacaacacctatttaaaactgaacgacgaagtgatcatgaacaggcggtacacc
150	3677835	CREBBP	YES	aaccagaggagttacgccaggccctcatgccaaccctagaagcactgtatcgacaggacccagagtcattacctttccggcagcctgtagatcc
151	2332491	—	NO	atccactaagaggcgcaagttggctgcctttccagaatcctctgattttcgttgatccaaggggctggaactgagcttcctttttcatgccaagtagggtccaaa
				caacagagaaacataaagctcttcctttctccccaacctcaccagcccttaccatggctggcttcccagtgattcattcaaggcaaca
152	2932426	RBM16	YES	tggggtccggccatctaatgtttccagtagttctgggattattgcagcccaaccaccaaatattctaaataactctggaatattgggaatacagccacccagtgt
				gtcaaatagttctggacttttgggagtgctacccccaaatatacctaacaattctggacttgtaggagtacagccaccaaatgttccaaatactcctggacttct
				gggaacacagccaccagctggacctcaaaacttaccccctttaagtatccctaatcaaaggatgcccacaatgccaatgttagacattcgtccgggactaat
				accacaggcacctgggccaagattccctttaatacagcctggaattccaccccaacggggaatcccacccccatcggtacttgattcagctcttcatccacc
				accccgtggaccttttcctccaggagatatttttagtcaaccagaaagaccttttttagctcctggaagacaaagcgtagacaatgttactaacccagaaaaaa
				ggataccacttgggaatgataacattcaacaggaaggagatagagattaccggtttcctcctatagaaaccagggaaagcattagtagacctccccctgtgg
				atgttagagatgtggttgggcggcctatagatccaagagaaggtcctggacggcctccactagatggtagggatcattttggaagacctcctgtagatataa
				gagagaatcttgtgaggccaggtatagatcatcttggtcgaagagaccactttggctttaatccagagaagccctgggggcatagaggagattttgatgaga
				gagagcatcgggttctaccggtctatggtggtccaaaa
153	3273785	ADARB2	YES	taaagtaagcatattgtcaaccttcctcgctcattcaagcacctgagtcctggcatcacaaacacggaggatgacgacaccct
154	4015409	TSPAN6	YES	tgagaaggctttgaagcagtataactctacaggagattatagaagccatgcagtagacaagatccaaaa
155	2428715	PHTF1	YES	ggccacagcgttcagttgatgtggttgtatcctcggttttcctactgacactttcgattgctt
156	3261500	NOLC1	YES	gtctgccaaggtcccagagcgaaagttacag
157	3144008	NBN	YES	cagacttttgactggcgttgagtacgttgttggaaggaaaaactgtgccattctgattgaaaatgatcagtcgatcagccgaaatcatg
158	3527425	PARP2	YES	atctgtgaaggccttgctgttaaagggcaaagctcctgtggacccagagtgtacagccaaggtg
159	3836942	—	NO	taccaggagcccatggatggcgtgacccagcaggcagcacagaatgtacttgccaaggcgggcaaagagtaaacc
160	2746889	—	NO	ggagtcaaacgtcagagcctgagacctttgatgaagggtcacatcgccagagctcagtgg
161	2853401	—	NO	gctgagagctagctttgctttataattttgtacttactaaaaaattaaataacttataaatggaggaaaacttggatcagttgatagattttgggggagttagtgaaa
				tttcttgaggggattttcaatcgaatgcttttattttctgtggcagtaatgatctggttggtttatctcataaataactgatgctgctgctttttgtgttctttgatgtctca
				ccttatgtttttactaagtaaggacagcaatggattggcactgatgc
162	3593678	USP8	YES	tgtcctgcgcaatgagcctttggttttagagggaggctatgaaaactggctcctttgttatccc
163	2466363	—	NO	tgataattggtgacgacaaggaaattaagacgattgctcaaagagatgca
164	2961018	—	NO	gatcttccacacaaagatcaggtgaagaaatctatgcagctatacatgctaggacctgagtacaccatccctgcaa
165	3307825	—	NO	ctgaggaatcttaaatctgggtataaacgtgaaatggttttattttttccttactgggtctccagtcatacagtgtaaaacactcctaacctctgtactttcctctgca
				gtgcagtcctttaagaatcccttggtccgatgtaactttgccgccact
166	3375666	FTH1	NO	gacccgcagggccagacgttcttcgccgagagtcgt
167	3510380	C13orf23	YES	gcagctgccaccgtttctggaatgaacctgctgaatactgtccttcctgtgttcccagggcaggtctcctcagccgttcacacacctcagccatcaataccaaa
				cccaacagttatcagaaccccttcattgcccactgcacctgttacatccatccacagtacaaccaccactcctgttccttccattttttctggcctagtgtcactgc
				caggtccttctgccactcctaccgcagccactcctaccccaggacctacaccacggtccactcttggttccagtgaagcatttgcttctacttctgcacctttca
				ctagcctccccttttccaccagctcttctgctgcttctaccagcaacccaaattctgcttcattgtcatcagtttttgcagggctccctttgcccttaccaccaacat
				cccaaggcctatccaacccgactcctgtaattgctggtggctctactcccagcgttgccggtccacttggtgtgaacagtcctcttttgtctgcgttaaaaggttt
				tctgacatccaatgacaccaatttaatcaactcctctgctttatcctctgctgtcacaagtgggctggcttca
168	4026959	HCFC1	YES	caagccagccaacaagcggcccatgtcctc
169	2888352	RNF44	YES	agagcagctcccgtcgtaccgctttaacccggacagccatcagtcggagcagacgct
170	3320634	USP47	YES	gagaaattgagcgcaatacatgcaag
171	3752442	—	NO	taggtgcatgacactgctcagtttgatgtgctaatctgattccagtaaagagaattgctgatttaatgttgaggcccgatcttccacaggtcctaaatgtttcccaa
				aatacatggatagcatacgactgggtttttttaaaattatcccaggtcaagcatgagtatctc
172	3188731	NEK6	YES	caggactgtgtcaaggagatcggcctcttgaag
173	3303115	—	NO	ctggaccaaccactacttccgtgtttcaagttcatttttagcacatgaacatgatcactgttagccagtgaagtagcttctgactagatcattgattagatctcaca
				aaaaaccaaaaatagtatatggaaaccaagatgagagcaaaagaaaacgttacctgagtaggcagctaaaacatattttgacattatttttaagcagcattcat
				aaggttcacgga
174	3820685	ILF3	YES	ggttctggcatttatgacccttgtgaaaaagaagccactgatgctattgggcatctagacagacagcaacgggaagatatcacacaga
175	3882554	—	NO	ataatgggatggcaaatagtctccccagcccagagttcaatatcctcctggttgctggctgagcttagactagaattatgttgagtttccaggacacccatttta
				cgaatgttattttgaattgcctgttgtatgtgataata
176	3054154	—	NO	ctacacgctgccgaggaaaacgcaacagacatggcaggtgcctcacgacaagaaacacttacaaatagaatcaaaactgattcaagtcataca
177	2624472	CACNA1D	YES	atccgcgtaggctgccacaagctcatcaaccaccacatcttcaccaacctcatccttgtcttcatcatgctgagcagcgctgccctggccgcagaggacccc
				atccgcagccactccttccggaacacg
178	3652530	POLR3E	YES	gactgctgtgtaagctatggtggcatgtggtaccttaaagggacagtacagtcttga
179	3980537	ARR3	YES	actaccacggagaacccatctctgtcaatgt
180	2808239	—	NO	cacaggtgaattgtctgggaagtcaggatgttgcacagaagctatgcaagtcatagattagaaaagcaagaatccacattcatgctttccagcatagatgag
				gagatactttttctccaccttcttagattcagtggctgggcagagagtgctgtgaattcatctgacaacaggcagattaacacgagaaaaggaatataagtttttt
				attttttatttttttatttttttgttttgagacagagtgtcactctgtctcccaggctggagtgcagtggctcactgcaagctcccacctcccgggttcacaccattctc
				ctgcctcagcctcccaagtagctcagactacaggcgcccgccaccatgtccagctaattttttttattttttagcagagacagggtttcacctcccaaagtgctg
				ggattacaggcattagccaccgcgcccagccaagttttttaatgtttaatctaatgtgcatggaggcatcatagaaagaactgaatatccaaaagtgtggtgaa
				atttgagactttagataccatcttaatgatagtggcaggaggcagacaaatcctagggagacaagggtgggtccctggtgaaaccccaccttcaaaccaaa
				gacagatttaagcatgaaagccaagctacaagtctccagtaaatccatggaccggattaagaatctctc
181	2811059	—	NO	ccatcagcttgtgactcatggcttagctggtctcaatggggaacaaaccagagagtctatggatcaacacaaagctataactgc
182	2858392	—	NO	ggcccagcttcatggatatacaaactatacattcacatgggttccacacctagatgggctcttacatcatgtagctggtcctacctgggagagagc
183	2779739	—	NO	tctgttcacggagcttagttctacttcctga
184	3298972	—	NO	gttaactataggtaggggacagagaaaggagcagagttaatgtatgctattgaagctgagttgctatcagtctgaactagactttgaactcagcatg
185	2933580	TULP4	YES	gaaactggccacgtgcgatgcggacggaggcatattcgtgtggattcagtacgagggcaggtggtctgtggagctggtcaacgaccgcg
186	3528128	TOX4	YES	caactaggccaaaccagtacagctactatcc
187	3528025	—	NO	cggcgctacgttaacttcgactatattaatgagcatcacgatcttcattttcatgatcccgtagtcctcgcggtcgtagaaaatgaaaggaaagcagccgttaa
				cacaggaagagcgaaaaaaggacattttccctggcgatcgtggc
188	3581134	AKT1	YES	gatgatctctccacggtagcacttgaccttttcgacgcttaacctttccgctgtcgccccaggccctccctgactccctgtgggggtggccatccctgggccc
				ctccacgcctcctggccagacgctgccgctgccgctgcaccacggcgttttttta
189	3676391	—	NO	tgggccatctcctcggtacaggtcagctgccgccggcggagctcctcatctgtctcct
190	2319003	—	NO	ccaagagcccggaattttcattacaactttcaaagagagcaagaggaggagggaaaaagatttcacaaaagcattatcaaggccccaacccaggatgccc
				tgctgtacaaccaaaatttgtaagaggtcagcctttcagggagtcaaaaacccagcatgtgga
191	2858313	—	NO	ctgcagagcaaaatatagaggcactaattttgttatatttgcagcccacatactgtaataccagatttgctcctgttgttct
192	3048750	—	NO	cgggaaacttcggaagacagctgtgcctggctctgtggctgcatgcagtgcttcacttggccagcagaggtcagctgtgccgagctgccccagccatgag
				aagagaagcctgcccttgctggcaggtggctatggccggcccagagccttcctgcccagctcctgcagccctgctgcctgggatcaggctgggagatgg
				gccttcctgaccgccagccttcctctccccgagcacacgcacatgtagattcggggggaagctgcctgctcttccttagaggagccggggcagctatctgc
				tggtccctttctgaacaactgttga
193	3360848	APBB1	YES	tgaggaggggacgttgaccttccca
194	3387192	CWC15	NO	gccaagagtggtaatggcgtctgtatgatcttcggagcctgctgcatcggacctcggc
195	3893880	—	NO	actccgcagggctggcacttcctgagggagtgggggctcaggcttcagacggactttattaaaatgtgtagtttgtgtgaatcatttcagtcaaaagtttcagct
				atactcggccgttaagacaacttaatga
196	2393792	KIAA0562	NO	ggaagggctgccatagttgccgcagt
197	2395248	RERE	NO	tcacagcagcgagcatccagggtttgcagggacgatgttacagactctgttttctgcctggcgtttcacttgtgtctgctcctagcctgtgctctgccagcagc
				acagacatctgctccatcagacctcttccattttgcacagggagtgcaggaggtgaatgttcactttctgttctccagtgtcactgttctgtttccacgggatgga
				aagcgcatgggcctgtgtccattgtagatttccttctagatttctgtgtacacacacttgattgttctggatgaatgtcttttttaatactccgaaaatttcatcatcta
				agaaaatgattccatacaaataactcagcacacaagtgacccaggacatatgcctgccaaagggatgtgttagaaggctgccttctcatgcgcattgtcactt
				ggatcttgtggtgaggacggccccatctttcttgccacagattgaggccacttttgagcaagggagatcctggagttaagacaggtgttgggggcagcctgt
				attttaccctaggggcaggtctgcatggtgaccccacattgcactggtaaaccatttgagtcccactcttcatcctggaagtgggaactggagtcccacccac
				agtgcattcagaaagcatgctgtgtgggggctgcttctcaggaggccaggcccttctgagcggaaccgtcctggagagagcctgccctcgtttccaggctg
				cagccgtaacgcactttc
198	3403226	UNQ2963	NO	ctcacccttgaggcccgggcacttc
199	3920956	—	NO	cccaaatgtgagttgcatcaaattcggtaaatgtagagtatgtttgttttctctgtacacaatactgacgtcagtgctagtgcctgcctaaactcagacaccagta
				gatccttttccaga
200	3970256	REPS2	YES	tttgaaaagtactatcaatgaagccttaccaaaggacgtgtctgaggatcca
201	2724115	—	NO	gcaggccttacttatttccacaggaccttataagctcatacactctattgcttattacgttactggaatctatctaagcagaaagaggctggcccaccttctgttat
				ctatgtttctatactctttggacttgcta
202	3351955	MIZF	YES	caaccacatgcgctttcgtcacagtgaggaccggccctttaaatgtgactg
203	3133234	PLAT	NO	ggaattctgcttcactcgcttaacatatacacaacacctgtaacatacaaggcaatgggctaggtgctccagaccgggaaaaggagggacaggaatgcttg
				gtctgatgggctaatatggcatttagagaagtaccaaggtacagtggagccggtcacaaaagggcagacttgt
204	2723089	—	NO	tttgtggctgttaataggaaggatgctggt
205	3102652	—	NO	tgtggcaaactaccacggcagatgtttacctatgtaacaaaactgtacatcctgcatgtgtacccctgaacttaaaaagttgaaaaaaaaaaaaaaagaaaca
				aataggctgggcatggtggctcaatgcctgtaatcccagcactttgggaggccaaggtgggaggattgcttgaggtcaggagttcaagacctgatatagtg
				agacc
206	3392531	—	NO	ttggacttgaatgactaggagaatgactactctaatgaacaaaaatgtaaatgttatatgtgggtttagtaagggaatgcaatgaacttggttttggatatgttaaa
				cttgagttatcactggaacattcaggtagaaatgtttagaaagcagtttgaaataagagtttagtagaaaggttgagagcagcgctgcagatacagatttgaaa
				gtcatctgcaaagagatgtgtcttagcgttctc
207	4015009	—	NO	tggaggcggccctacacctggcaatggaggt
208	2596170	INO80D	YES	gatgagttgccggatgacattgccaatgagatcactgacattccacatgacttggaattgaaccaggaggacttttcagatgtcctgccacggctacctgatg
				acttacaaga
209	3591676	—	NO	aaaacctggaatgctgtaggacatgtacccactgaggcggatgcaaggagcgatggagaggaagga
210	3680412	—	NO	tttaccccttctcggtgacatttgc
211	3906169	CHD6	NO	ctgcttgacttactgggtgatattgggctacaactgagactcactttgctcctgtgtaaagtggggcaacagcatctaccacggagggttgaagatttacgga
				gatcatgctaagacagtttgttccaaactcaaaggaaatcatttgcaaacaacagaaaaggtcagaaaccgtatacctggccaagagagatcccttttacgct
				ttgtttaatgtttcatgttgtattttgggttttcccatttactggattctgagctccaaaacaggaatcacattttatgttttcttattttaaaagcaataataataactagt
				acttattgagtgcctactgcttaccatgttcaaggctttacatgattatcttgtttgttcctcacaaccactctgaagatgggctttgttattcccattttataggtgag
				gaaaataaggctttaaagcattaaataatttccccaagattatccagctagtaagtgacaaagcaggaaaccaaaccaaggacctttttctctaggggctgaga
212	2803102	—	NO	ctatatgtagctaccctgtggcctccccctaaggtaaccactttactttttagtagtgaagaatgtctaaaatataataaaggtatatctagaacacaaacctcca
				agcaggaacaacccattatctctcctttgcatgccctgtcaatggcttcaaggtcaaagctagctaagtctctgagtgtgtagggagctgacatcttggtgaaa
				agtccttcagtacatgctagatcatagctgacttgcactatccttccaaactttggaatatctctctggtattggattggttacaatggaaacagaaagattctgat
				catacaaaataaagattttcatttgtgagctcaaccattggatctgtcatcttccattagtagaaaaaatgaggaaatcaaatactttgttttgtttttaaccacgcag
				agaaggaagagagtagagtgtgggaaattgatatatctgccttactgccccagcccctccctctggagtgtgcaagtggtcagaagtcagcaaattacttttc
				catcatatttggccccaaactaccctggtgagtgaggagaaagggaatcatttgataaggtttggaaaatagcatctgtttttcttagtgtttctggatgaatttat
				caggcatccggtaatttgtactttctgttgaaaactataatagaataccgtgcatagacatgaaaccttttggtattagtcagaagctacatactgactgctgttgg
				agaagaccacatttacagtcaagggtagaatcatctgaaatagtttcccctggaaaaaaaaaaaacatggccatatatgcctacatagatctcctctttgcttca
				tgaatttggaactaaacctgggtgtttagataattccagttctaggattttctcaccttgagtttattccccttattcttactagttcagtttggccactgtacatatgga
				gcttactagaggcaaagcactctgtgaggggcaatggttataca
213	4025793	—	NO	ttgtgtctgctccaagtgcgaaccctccatgcactgcagagaacaccagaaggagaggagcactacctgagcttctccttccgggtctaaaggtggaacttg
				ctttgcagcacccagcatttcactgtactgattcctttttttggatcaccacctcctgcgtttagcagcccatatgctgggctcactcagctatacactgcttg
214	2616236	FBXL2	YES	aattttggaggctgcccgatgctcccatttgactgacgcaggttttacactttta
215	2959832	LOC100128757	NO	tccggtgcttacctctaactgataaaactagctccaacccaccaccctccactgacttccttcgcactcagcccactcgcacccgggtgaataaacagccttt
				gttgctcacacttagcctgttcaagttgtctcttcaattagatgctcgcataacatttggtgccgaaagcccgggataggggaactcctccggcagacctctcct
				ctatcctcccggtacccacgttctcccatgcaagagacttccctcgccctcaggacctcagaccagctccgcgagcactccggcctctgtctatgga
216	3072195	—	NO	ttagtgtcgtcaggagactccctccatcagaattactcaggctgattgttttgagtcctgggacccagttggtatccagaatcttggcttgtttgcctaggaacc
217	3757471	ACLY	YES	gggtgtcaacgagctggcaaactatggggagtactcaggcgcccccagcgagcagcagacctatgactatgccaagactatcctctccctcatgacccga
				gagaagca
218	3986531	—	NO	gagggaggaattacgtggtgaaggatgaagtgaacagcggtgcttggcatataagccagccctcaaacaag
219	2696767	MSL2	YES	cttcctgtagctggtgcaaagactatgagcagtttgaggaaaacaagcagttaagcatcctagtgaactgctacaaaaaactatgcgagtatataacacagac
				tacactggcacgggatataatagaagcagttgactgttcttctgatattttggctttgcttaatgatggatcattgttttgtgaggagacagaaaaaccctcagatt
				catcctttactttgtgtttgacacattcccctttaccttcaacctcagaacccacaactgatcctcaagctagtttatctccaatgtctgaaagcaccctcagcattg
				ctattggcagttctgttatcaatggtttgcctacttataatgggctttcaatagatagatttggtataaatattccttcacctgaacattcaaatacgattgacgtatgt
				aatactgttgacataaaaactgaggatctgtctgacagcctgccacccgtttgtgacacagtagccactgacttatgttccacaggcattgatatctgcagtttc
				agtgaagatataaaacctggagactctctgttactgagtgttgaggaagtactccgcagcttagaaactgtttcaaatacagaggtctgttgccctaatttgcag
				ccgaacttggaagccactgtatccaatggaccttttctgcagctttcttcccagtctcttagccataatgtttttatgtccaccagtcctgcacttcatgggttatcat
				gtacagcagcaactccgaagatagcaaaattgaatagaaaacgatccagatcagagagtgacagtgagaaagttcagccacttccaatttctaccattatcc
				gaggcccaacactgggggcatctgctcctgtgacagtgaaacgggagagcaaaatttctcttcaacctatagcaactgttcccaatggaggcacaacacct
				aaaatcagcaaaactgtacttttatctactaaaagcatgaaaaagagtcatgaacatggatccaagaaatctca
220	3188391	—	NO	caggggtacacccacatctattgtattagacaaatcacagagggattgcaacagaacacagatttttctcactgttttttctctggttgatcgggatgcattatcc
				accagaaaacactgtagacgactcactcaccaggaaaagagcatatgccagttggaataaataaaggggaagagtaaggaagaggctgtagaattatttta
				taaattatcaagtcttatgagccaggtgc
221	3846196	—	NO	tctggccaatgcatattacttaagggcaatgtcgtggccagctgtggtggtctgggctctccctctgtatcgcctggggaggctgctgaggtgactttttggaa
				gaaaacacgggatgagtgtatgatggtggctgtggagaccacccaaaatcccggggttgggggcaatagtgaatgaatgggaccatctgcgtgggtccct
				acacgagatgcttg
222	3070747	—	NO	gagctcattctgcgtttcttattgcttg
223	3821522	—	NO	gtagataaccatttgtcgctgctttttctgttaagtgttcaccacttgtatcattggctggcaatacctggtttgtcatagttt
224	3875001	—	NO	agctcctccccagaataccatgctc
225	3279450	C10orf97	YES	ccaaagtttaattaatctcctgctgacgggacatgctgtttctaatgtatgggatggtgatagaga
226	3541293	PLEKHH1	YES	tctttctctggcctggtctacaagaatgtcac
227	3547709	TTC8	YES	cctggaacgtctttgaaactccctggaactaatcagacaggagggcctagcc
228	3875261	—	NO	gccaaccttggtttgtgcagtttaaggaaaaaagccatctccataacatggaagtgcaagatgaagcagcaggcactagtggggaagctgcagcaagttat
				acagaaaatctagctaatgatgagggtggctacactaaaaacagattttcaatggagacaaaacacccttctattggaagaagatgccctctaaagctttcata
				ggtagagagaggtcagtgcatgggcttgaaagaacaggctgattctcttgctagaggccaatgaagccagtgagttta
229	2584791	—	NO	cactggaagaatataggttggctcagacagtccataggaaggctaaataaccacgctcaggaaatgggccttagagagtgggaagagaaaatgtatctaa
				acttatatctcagtaacagcttgataggacattgtcactagcagtgccaccactaggtcctca
230	3204563	KIAA1539	NO	ttgccagcactctgaacccatgcgggctaatgacctgcccatcctg
231	3356165	APLP2	YES	cgagactctggatgttaaggaaatgattttcaatgccgagagagttggaggcctcgaggaagagc
232	3650891	—	NO	tacactccctcagggacagtcttgccatttcccgtttttcattcttataaacaatgccctggtgcaggggtcagcaaacttttctataaggagtcagataatctttttt
				ttttttttgtattcccttttggcaatttgtttaattgagataaaattcacataacttaaaactcacccttttggtgtatacgattcagtgctttttagtatattttcaagattgt
				gcaaccaacaccactatctaattccagaacatttttatcaccccaaaaaggagccctgtgccaattagctatca
233	3829699	GPI	YES	actgaagcccttaagccatactcttcaggaggtccccgcgtctggtatgtctccaa
234	3971251	CNKSR2	YES	cctcttatacctagaagtcccacaagcagcgttgccacgccttccagcaccatcagtacacccaccaaaagagacagttctgccctccaggatc
235	2359255	—	NO	agttgtggaggcatgtttataagcagatctgagttttgccacactggaatttatttat
236	2811000	—	NO	ctgggtctaggaagccaggtactttgtgctgtttcaacaagagctcttctgctttaactagttt
237	3391986	—	NO	gctggagaagttcgtctgggacaaagagctctggcctcatgcctgtgggtccagcagtcaaactgggacagactatgtgaaaagggacccac
238	3888361	—	NO	agcagcctcccgcttagcggagagtgggatgagcacatgcgcggccgacagggaagagtgaatccagagcagaagtcaagggcaagactcgtgggg
				gggggaagaaagggacagaagccagctcccagcaataaaggtcgggttattttgttcttttgtgacatgccctatatc
239	3897502	—	NO	tctcctggggacttacatagctgtttggtttttcaacttgattgaagaaagttattcgggggatctgtccaattcacaccttctgttccctgatcaaatactttagggt
				caaacataaggttttattgatttttgctcaagcaaagaattaacatttttgataaggaactgtaatggcaattataaggtaatatggtgtatggtaatattatgctgcc
				agaggaaacatttgactatgattaaattcaagcccagtactgggtagctctagataattaaagataattttatccattcaagtcccctctgttaagctgcacattga
				ca
240	3235381	DHTKD1	YES	acagtatattgtgagcatggtcataaagctgccaaaatcaaccccctcttcaccggacaagccctgctgg
241	3286657	—	NO	tccagtgaggccacatcatgacttcccccatgaagacatcgaattcacggctgccttcacctttgtcctgtcaatgtctgatctttcctttcaattacagcacgag
				gctggggttcca
242	2714224	MYL5	YES	tggaccagatgttccagttcgcctccatcgatgtggcgggcaacctggactacaaggcgctcagctacgtgatcacccacggggaggaga
243	3331851	GLYATL1	YES	tgaaagtagagcattcgagagcactcctcttggttacggaagatattctgaagctcaatgcctccagtaaaagcaagcttggaagctgg
244	3356559	—	NO	gccatggttctcttgtggtcagctcttgttctaatccttagcgcccatttggaaaccagttatggggaaagcacaatgtaggactcttgggactctgcacctgac
				tggctggctttccaagatcactgagatggctcttcctccagcatagaaattgatggctggttatccagacagcaacctcttttgcccatgtgcttggtgctctgtc
				atggcgggaaaagtaactatgcacagatcatgattatggtattagattgggtacacatgaaattgctagtatgcacctattttgatgtatgaaaatatcattttcat
				gagattcatcctaatttatgctatgtatggggcctgattgccctaacagctcatc
245	3636325	—	NO	atcagacaccgcctattcaccagctcatctataaaaccccctgcatttcaccgcagaactggaacctatt
246	2539613	—	NO	tccattcttgcgcttaaaaactgtacctaactccctcccatagcagacagaataggataggcttcttccctacctggtgttcaagttctaccactgccctcctccc
				ttcccccatttacctctctagaattaccaggtatctatgcatacatgaattctctgcttccattagatttacttgtcattccccaaatacaccatgcacttgcatattag
				caaagccaagtttgtctttcacaaatgcagaggttaaataagagttaaggatgaaggtaaaccaaactttatttatatactatattttaccaaatatgatttaaggat
				ctctaggcagtgttgtctta
247	2860647	—	NO	gcaatgtggaccagaccatcgacaacccctatgccacctttgtcaagatgctaccggataaggattgcctctacgccctctatgac
248	3143676	MMP16	YES	cccgatgcggtgtacctgaccagacaagaggtagctccaaattt
249	3492475	—	NO	tgggctgaccacagactttaccacaaa
250	3698355	ZFHX3	NO	gtccgagcctccgtactgggtgcaatgaaagc
251	3364564	—	NO	attggcgtggttcttccccaggataccttatagagtctagtgaacttttcctgtttgtggaaacaatcaggctgggtttaaatgaggacttgtctctatttggagcat
				ttgtgagcgtgtaaggaaatgagtgttt
252	3101645	ADHFE1	YES	agggagcttttgatgcctatgttgctgtcggtggtggctctaccatggacacctgtaaggctgctaatctgtatgcatccagccctcattctgatttcctagattat
				gtcagtgcccccattggcaagggaaagcctgtgtctgtgcctcttaagcctctgattg
253	3015159	ZKSCAN1	YES	agttcatggacctgagatgctcgcaagggggatggtgcctctggatccagttcaggagtcctcgagctttgaccttcatcacgaggccacccagtcccactt
				caaacattcgtctcgg
254	2686624	IMPG2	YES	atacctttcaagctgcatggccctcagcagatgaatccatcaccagcagtattccaccacttgatttcagctctggtcc
255	2897644	—	NO	atgttgggtcccaccttacatttagtttcatgtccccttagtttcctccaatctgtgacagtttcttaattttttcttgtcttctgtgaccttgacacttctgaagaaaaca
				tttccttgatatttctgatgaaaatgattattatgtagaatgtccttcaacttgaattggtctttttctcatgattagaatgaggttctgggtttttggcaagcagagaac
				agaagcgatactatatttttctcagtgcgtcatatcggggtcatgatgtcagtgtgtcttatactggtacactaacccatgtctgctaggtttctttccaatacagtca
256	3909740	—	NO	ggtggagcaagagccctgttggctgatgg
257	4049026	—	NO	ggcacagaagggcaaattccgcacattctcatttgtggg
258	2321582	—	NO	atggagccagaaaaacgcgtgcagcagctcatc
259	3304498	ARL3	YES	ggcttgctctcaattttgcgcaagttgaaaagtgcaccagaccaggaggtgagaatacttctcctg
260	3533002	—	NO	tactgaatgtgcttggttttggacag
261	3568039	PPP2R5E	YES	ctcttgctgccgctgcagatccagtcttcctcc
262	3764440	RNF43	NO	tgcggaatttctcggcacctacctgtagtatggggcacttggtttggttgcagagtaagaaggtggaagaatgagctgtacttggttaagcagttgaaacctttt
				ttgagcaggatctgtaaaagcataattgaatttgtttcacccccgtggattccagtgggcccgaca
263	3790080	NEDD4L	YES	ttgggaaagcagataaccctgaatgacatgga
264	2658005	—	NO	gtattatcacatgactgccaggtgc
265	3029676	—	NO	gtctgtgggtggatagatccattaatggataagtaaatgagcaatgcttcctgggttgaggttttggattactgtggtcatgcactgcattggagatgaggtgga
				aaaaccatc
266	3390272	—	NO	gagtgggcactaggaaacggattcaaagaggcgatgaataatctgagttttacaggtttaacaggaaggcataacattgtaagcaaagaaagaaaagatatt
				ccagacaaagcatatgtgg
267	2642810	DNAJC13	YES	ctggatggagtaagagcctctggtaatagagatgtttgtgtaaaaatgacaccaacccataaaggtcagcgatgggggttactcagcatgcctgttgatgag
				gaagtagagagccttcacctcaggttcttagctacgcctccaa
268	2811129	—	NO	gatgagatattaactgctgcactgg
269	3070222	AASS	YES	tgagaaaatggtggatcatagaggagtacgggtagtggcatttggaca
270	3907114	TOMM34	NO	cctgcctgaccttacccagagaagccatgggccacctgctctgtgcccgctcctgaaaccca
271	2790942	—	NO	atgttcccataagcaacagcctgtaaattgtcacatgtaagtcatctaataagtttagaacaatgaacaactcattttctgaactgggacaaacaaggaagctaa
				attca
272	3043075	—	NO	aatcagtgttgcctggtggatagcaaatcaagtttcaaggttacaga
273	2354095	WDR3	YES	ccatggtgaaatggtgggaccttgatactcagcactgctttaaaacaatggttggccaccggactg
274	2713294	—	NO	tggattgcgtaaaggtggggacctccagatcttccacgggaaaggtacgtttttcttgttgatattgtgaagtgtgtatggggttgtactttggcaccttgtagtg
				agtcagtttccccccattggtgatcattgccaaatca
275	3220577	KIAA0368	YES	agatgttgcatcaaagggccttgggttggtttatgaactaggcaatgaacaagatcaacaggaattggtttctacacttgtggaaacacttatgactggcaaaa
276	3531076	SCFD1	YES	tgttactcgtattttggacaatcttatggagatg
277	2505303	RAB6C	NO	gcaggaagaaaacttcgagttacaggtcaggaaaagc
278	2644040	PCCB	YES	gagatcatgcccaattatgccaagaacatcattgttggttttgcaagaatgaatgggaggactgttggaattgttggcaaccaacctaaggtggcctcag
279	2938530	—	NO	gagaatgccggtggggccttcagcagcagcatcctaacagtgttgca
280	3625346	CCPG1	YES	gaggccctactatgcaaaatgatggaaggaaagaaaagccagttcactttaaagaattcagaaaaaatacaaattcaaagaaatgcagtcctgggcatgatt
				gtagagaaaattctcattctttcagaaaggcttgttctggtgtatttgattgtgctcaacaagagtccatgagcctttttaacacagtggtgaatc
281	2971361	—	NO	ctgcctagtattgtgctacagtaccagacaaaatcactttagggttttggggttttgtttttttaaacaaactggtatgtaatataaacttaggaaccaccaccac
				catctcgagtatcaatgtttcagaatggaggcatagttcagtgaaaaaaatgccggcattggttttagttttgattcttgtttcaccagaaagcatggtggttggg
				ggagctgtcaaagtactccggatagactcagcgccattaaataagctcaggcatatacggccaggagcaa
282	3026661	TRIM24	YES	aagtgtgagcgcctacttttatttct
283	3108906	—	NO	ctgcatcgaaccagcgacctgggtgcctccccacccaagacggacctccacatcgggaa
284	3649134	MKL2	YES	ccagcagccctttatcaataaggcctccaacagtgttcttcaatccagaaatgctccgcttccatccctgca
285	3729183	CLTC	YES	ttattgaagttggcacaccacctacagggaaccagccct
286	3900156	C20orf74	YES	tcccaacaaaatcgtggcccaggtagcttgcgatgtccttcagttgctggtttcctactgggagaagcttcagatgtttgaaacctctctgcctcggaaaatggc
287	3907653	NCOA5	NO	tttcctctttggaactcttgtgttgtt
288	3102604	—	NO	ttggtcttcacgcactgggtgtgtctgtaaatacagcgctgtccacggtgtctgtcctgcttccatcccaaattcaggctttagcttaaaacatctttagtttaatttt
				ttaaaaaattcttttctttcccccagataaaatcttaatcttttgcactagactgttagccagggaaa
289	3863282	—	NO	gaagtgtttccagacatcccaattc
290	2920506	—	NO	gcttcttcgtggtcttttccattat
291	2319069	—	NO	ctgaagcagggtgcccgtttctacaccaaagagcggcaaaatgaagaa
292	2573693	CLASP1	YES	gcttctgggcctgcagaacttactgaa
293	3022667	SND1	YES	gtgcccgagtagagaaagtcgagtctcctgccaaaatacatgtcttctacattgactacggcaac
294	3570810	—	NO	atgtgggtggagatgatctttgctttgagaacaggattcattatgtgggctggtcaggagtgggaacaagagcaggaaggccacaggggattgagagtact
				tctgtccccaacacactcatcaaggacgtgcaatcgggggccaaggctcattatggtgattttca
295	3847162	—	NO	tggccagctccctagtttgtgcttactatacctggccacgcctccctacctaaggccgctggcttaaccctaggggcaggcagtgttagatcagacccagac
				cttctcatcccaccctcatcacatcggggagaggggactccaggggcgggaaggcaggcgtccctccatttggccagggtgggcggcgaggaggggg
				tcactctgcaggaacactgagctctgaacacctct
296	2535304	—	NO	tcaacaacatgaatggcggcaacactaggagacatcc
297	2697615	—	NO	tgcagtggtactattttagctcaatgcagccttagattcttggact
298	2931795	—	NO	agatggcatgctgcacaagggattcatggttacagcgggcttgtgggactggggctctccaatacgtggttgggtttgtaaagaaatcaga
299	3011882	STEAP2	YES	caggttattgaacttgcccgccagttgaatttcattcccattgacttgggatccttatcatcagccagagagattgaaaatttacccctacgactctttactctctg
				gaga
300	3464921	—	NO	cctgataataagaggaacgaggacagctcagaaagtacaagtcaagaagccctgagaggggagtgaattcaggaaaccggacatttcaggtttgcctca
				gcattgcatgagtttgaggaacaagaaaagatgaggatggattgtgaatgatctcgaatgtgttttgaaggtttttggaggtatttggattcaccctaaga
301	3541610	—	NO	aggtcgatgggctcagaattcactgacaggttcagatccagccgagaagtggagcatgtatggtattagtggcatttgaaggtcattagtggcataactattgt
				agtgtaaattcaagttttattggtatattgtgtatagccctgcaga
302	3872499	—	NO	ttaggagccatcaacgagttcacgccggagaaagacctttcaagtgtggagaatgtgtgaaatctttcagtcataagcgcagccttgttcaccatcagcgagt
				tcacagtggagaaagaccttatcagtgtggagaatgtgggaaatctttcagtcaaaagggcaacctcgttctacaccagcgagttcacactggagcaagac
				cttatgagtgtggagaatgtgggaaatcatttagttcaaaaggacatcttaggaaccatcagcaaattcacactggggacagactttatgagtgtggagagtgt
				gggaaatcttttagtcataaaggcaccctcattctacatcagcgagttcaccctagagaaagatcttatgggtgtggagaatgtgggaaatcttttagttcaatc
				gggcaccttaggagccatcagcgcgttcata
303	2470335	—	NO	aaggcgttcgttatgtgggatatgctgttaccactgaacttgaagttatcaaagaagt
304	2887649	—	NO	ggtaagtggattgacctctaaactccctagaagggctgtagctttgaaggtggacatttattgggctcgcacgtgacacttattggggctaa
305	3522210	—	NO	gtgagaacctacatgttgggtgcccacc
306	3674221	—	NO	agtgagcgtttgagtgaaccagccacagtctctacgtgtcatccaaggagcccggcacagaccccgtgtcacccccatgtcacccgcagaccccgcgtca
				cccatagatacgcaca
307	2560167	—	NO	gggacacagagcagttgaggatatctcttttctttcactctgttctgaaatctgcctcttcccaaaggtactccatgacccctaagatactcactctg
308	3041159	—	NO	ttaattcagcacaactcaccattcccactggaaacatactggcaattcacatcttccaaacaagg
309	3183335	FKTN	YES	gaggcactcaggccaaaacaggaaaaa
310	3204049	—	NO	gggcgccatcggatggggcaaagagatccctgaaaacgtattgccgggggacggggacttgcaggacaagaaaaccgtgggagaat
311	3393003	KIAA0999	NO	gttgattgtaaacccacagtatctagcagcgttgtgccaaattgcccttgtgtttctctccacccaaaatatcacagctgctttcctcacatttggttcatccgtgtg
				ctgttctttt
312	3598130	—	NO	gccaagtacaaagtgctgtcccatatattacctttatcatcatgacaagcacttgagatggtaattaacaactccactttaagtctgagaataatgaagcaactg
				acccaaggctccaaagacagtgaatggcagagatgagattcaaacccaggtctccctgactcgaaagcccacgctttcccccaacaccatgttcttttccttc
				cctgtcagaaagggaaataccaaaaacaaatgagggtatgtatgagggtttggctggagccccagtcagccaaagtctgattccaagtggactgcagggt
				ccgtgttatctcccttgggcacaatctcaaaagcccagaattcagctgccttgctaaccttccatcccagtcttagtgagaagctaaactaacttctgggcctca
				attacagcagatta
313	3681604	LOC728138	NO	tgccatagaccctcacgtgtttgttgcattaattggataattcaaaatataaagtattatccagtttcaggataatattaagatctaaaccaatgaatgctctatgaa
				aagttgtagattaactgatcccttaaaactaaaaacagcgtcttcataagcttctactgggggcagctaccactttcttcatcacatttcttatcctcaatagctgtg
				ggcaatgccaaaatagc
314	2410882	ATPAF1	NO	gttggcccttcacctagttgactcagccctcgatagtctagagcccaccccctcctcaggaactcaagagctcagcatttataatgagcagttggtaatgagtt
				gccctatgtgcttgtcgcaagcagtcacagagatgagccctattacttgatattcaggaacaaaggtacctgaacattctgataattatctcagcatacttgagg
				tttccttttttaagtgttcgaggttataacaagagacagccaaggacctacaagacagttgacttgattttgcacagtgtaacagcgcagttgcattctggccact
				ttgaccttatagctcccaaatgatgagtttgtcatctttatgaactcatgacaggataataagcttgaagacctgctgtagttagatatgggctttaatccttcccag
				gcaccagtcagctgaacaaaagcataagccaaacatcctgtttaaactgtagaataaccagatattcccatcaggttaaagacttcatctagatgatgccccc
				cagagatgcctttagtgtaagtagctggcttggggtatcagcaaatttcaggtatagttagataaacaggtacagggcctgcatactattaaaccatagtttgtg
				gcacccgcttttcta
315	2821250	CAST	YES	agggccagatgatgctatagacgccttgtcatctgacttcacctgtgggtcgcctacagctgctggaaag
316	3134070	PRKDC	YES	gattggagcaatgatgtaagagctgaactagcaaaaacccctgta
317	3888286	—	NO	agctccagttacatgggcctgttaacatggcagctttgtctataagcaaacccaggagagaaagacatagcagagatggatgtttgaagtctataccttccac
				cccctttaaagagaaagtaacaccactccttttctgtgtcccttggggacactacctccatgtctggtcacatggctggactttacagcagataagcatactgtg
				gcctgagaccatgattgtatgctttccttctgctgacctttacaatccctcaataaattgagctaacacagggaagcttttttaccaaataactgtgttgcatcatcc
				tccagtttgcctggtgtccttaatcaatggaaggggaataagcaaactgagttttcttacaccttttgagtatagtgtttttgccatcatagatgtggctcctcataa
				ttctccaacttttatattaaaaaaccaaaacctcaaaaattgtagttcatgtcagtcagtgatgactcatcttagaagtattttgtttttggatgtgtgaatgtgcatag
				ttcttaaagtccaacattcatgtaataagacatcttgcatataacaatgacccttacgtctaagatgttaaatagatcctaagcctggtataactttattcaagtatcc
				ttatttgcccctaaaatgtctttaatacacattacttgggttatttcttgaatgaacatacaggtatcccaatttctgatttttaagagaatggggtcttgctctgtcaccc
				aggctggagtgcagtggtgcagtcatggcttactgcatccatgatcctcctgcctcagcctcccaagtagatgggactgaaagcacacactgccatccctgg
				ctaatgttttcatattttgtagagttgcagccttgctacgtgacccaggctggagtgtagtagctattcacaggcatgattgcttgaaactcatggcttcaaggga
				aactccca
318	3919790	—	NO	gcagggagtgcagaaaccttggagaaagtgagagattttccagccaaagggaactttgtgtttccctggctgggactcttggggatctttttcaggttttctgca
				gtttttctgaattgagctttaaggcaactggatggattttgaact
319	3948965	—	NO	cttagctgttccagcggcccatgtttaaaagaatgtgcttctttttccaagtatttctgccgcttgcatgcactgagcttctttggaaaggagcaccatgcaggca
				tattttccagacaggaccggatttgctcgttactcaga
320	2738676	—	NO	ctgagacctgaagcacgagagccaagtgtgtaagcaagtcgatgggattgggaagaagtttaggctgctaaaaaatttttacataaagcttgataagaggg
				gatattgcatgtgaaataaacagaaattcagtaaatatggtggaagtgcaggatttaggggatggaaaaaaatactagtttcaaaaattgaggctagaagtga
				aggtaggggccagattatgaaaagccttgtaagcaatgctaagaaacaatagatgtcagaaggacatgccaccatctaaaaagcagtcttgagaacaagta
				attggataaaggtgacctgactaggtatttgtttttttaagtaaattgtgttaattttgttaggtgtaaaaatggcattagggtcatgttggggaaaaaagaatctctt
				tcttacagatgaaattacatggtctctgagactgcttccaaaaa
321	2929182	—	NO	tgggtgtaaacattgatgatccttctaatactctgtcctcttaatttctctaagttctctttctagtgatcttgtctcccagtgtggtgggtatattctggctagaccag
				gtcattgtttatggtggcagcccctctgtcatctgaatttaagcgtcccattttttcggtactagcatggctcactgc
322	3004581	—	NO	gcaaatgttttaatgggccctcctaccttacctgacataagataattcatactagaaagaatacctacaaatgtgaagaatgtggcaaaagctttagtgtattctc
				aacctttactaatcataaagcaattaatactggagagaaatcttacaaatatgttgaatgtgacaatgtttttaactaggctgcaactcttgctg
323	3300811	C10orf4	YES	tttggatttaggtggcgagtagaaaaa
324	3426258	—	NO	atggagattaagcaggaacttcaagaaagccaagctcttcttggtagcacaccagagtctgaagg
325	3645807	—	NO	agtggaatctctgaaactcaggtgtggcatcaacaaag
326	3976960	—	NO	caaatcccgggtggcagccataatccccaaagatgacccccaccccaagattccaaagaagctagtggtggtggaagcaaaaggaatgcagcaaggtc
				agggtttcattgtccaagccggcctgacacctgccgccctgcccttgcccagtgcacaccctagaccctgggccggcctccatgcagctggaggccagaa
				gacagcaacccatatctttgcaccctcctccatgccccatggcctgcctgcccagaaagatgccaccttcacagagccagtgctgtcgtctatatcattt
327	3981121	OGT	NO	ccgtcgccgccatttcaagaccgtactag
328	2391399	CPSF3L	NO	gtatgcaccggcttatgaacccaccaggctctgtccgagcggcattgaaatggccagagtgggacaggctggtgccctcagagcgcttggagcggccag
				agactcgctggagctcccggggtgttgccgggcagggaggcaggggctggaggggagatgggccagctctggagggtgcctggttctgggtgtgggt
				cagggaagaagtgaaggttaaatcagcgagtgacaggtgaaattccatttctgacaaagattatgggtttgtctgtgtctcactcgaatctctggg
329	2748879	GUCY1A3	YES	tgcgaattggactgcactctggatcagtttttgctggcgtcgttggagttaaaatgccccgttactgtctttttggaaacaatgtcactctggctaacaaatttgag
				tcctgcagtgtaccacgaaaaatcaatg
330	3063716	—	NO	gtgagtggttagagaacaatggcaaacaaagggcgaggcgtttaagcttctgtagagagg
331	3361874	TRIM66	NO	tgggcttccgtgatcccgttttctagtttggggtaactgagtcttgaatgctttactagtccggcaatctttggacttaggcttctgccctttgagactcacatgact
				ttctggtttggggtctggtcatttccctttcaatttttgaatctccttctctgttcagttggcttggcaaagtaccctctgttctcatg
332	2812780	—	NO	tctggaatgaaacagcgtaatgagatgagccctga
333	3065419	—	NO	ctacaaggatactcaggtcagaaaggcccaggagtacctacctcattcagcaacagtccagtcaaaatcttcctccccgacaatggcctatgaccagcctgt
				tctacacattcctctctgg
334	3077669	—	NO	aagagcccttctcaatggcttaacccatagagccc
335	3652961	—	NO	aagcggaggttggaggaagccgtgattgtacc
336	2895678	SIRT5	NO	aaagcagccgtggagacaaccatctt
337	2978057	—	NO	ctgtgttgtctcagtcaagcctagaactgaagctacctgacatcaagccaattgtccaggaccagcatttccagcacttccagttgtccatatctgcacttccag
				gagtaaacaggca
338	3595946	RNF111	YES	caaggccacttcatcatcaagcttctgcctgcccgcattctcatggaaacccccctcctcagactcagcctccgcctcaagtggattatgttattcctcatcctgt
				acatgctttccattctcaaatatcttctcatgcaacatctcatcctgtggcacccccaccaccaactcacttagccagtacagctgcaccaatccctcagcatctt
				cctcctacacaccagccaatttcgcaccatattccagc
339	3628693	HERC1	YES	tataggaaatcatcaggagccaagtgtgtttatcagctgcggggacacatcactcctgttcggactgttgcctttagttctgatgggttggccctg
340	3734777	MRPS7	NO	gtgagctactgccacgctgaaaactacctgtgggttaaggatgtagttcctttgtaagggtgggcaggcctcgtaagaaagatgtagcagcatattcactatc
				cgttaatccttctttctttgaggctggaacttgctctctctgcccctatttccttgtaaagagggagcacattgacttgggaatttcctccaggaaactcagggctg
				tttt
341	2806269	DNAJC21	YES	acagagctggatgactatggccaatttggagaaagag
342	2849121	DNAH5	YES	atgaatcccaaagcgattactgccccacagatgtttggtcggctggacgttgccacaaatgactggactgatgggatattttctacgctttggagga
343	3012989	—	NO	tcttattcttggccacgggaccaaccctcacaggggcactctatgcagaagcttccttcctaaattggaactcccactttgaccactctccttt
344	3184655	—	NO	ttgcaaggcccacaccacgtggctgagaagtcaactactacaagtttatcacctgcagcgtccaaggcttcctgaaaagcagtctaacagcaaaagaaaag
				cttatattaaataaatagttaaatattaaaccttcaaaagaaagactcgacacaatgacacaaagcacattctggaggtcctc
345	2428776	RSBN1	NO	gctgcccaagatgttggaacaccatgtgcaataaagggcttcgtcttggattttggccttattaccacaaccag
346	2502833	DBI	YES	acggcccgggatgttggacttcacgggcaaggccaagt
347	2608589	—	YES	ttccattgatgaattggataatgctgag
348	2781610	—	NO	cttacaggagaaatcgaaacacagctgctac
349	2810989	—	NO	ttagagtttatggaccttgctcttggtta
350	2489148	—	NO	cctctgccttcgctcgcgccgctctccttcagtctccccagggcctgtttcatggatagggtccccttgcccgcgtgaaagtctcattcctc
351	3239162	—	NO	ccactggctaataagcaggtctttattgagtgcccaacactgagtttagtcacaggtgcttattctggataattaatctcagtagattaaccttcttcagaatgacc
				atgtatatcagacttctcttatccccaattctgggtccttattaacctcttccagggctaagtatttacccttccataaatcggatgttttcttaagcattttttctcctgt
				catcactgaaactccagcctagttcttcacttgtatgcaattttcttgtaaccctgtctctcgttttggttttattgtccatatgcctattgagtgcttttccagttg
352	3573019	POMT2	YES	ctgataggtcttgctggctacctgagtggatatgatggtacctttttgttccagaagcctggggataaatatgagcatcacagctacatgggaatg
353	3937196	DGCR8	YES	ttgtgcccccaaaaagaggcgaacagaggaaaaatatggcggagacagcgaccatccgtccgatggagagacaagtgtgcagccgatgatgaccaaga
354	3154331	NDRG1	NO	tgctgggcgtcaagcttgcataatgccgtactttgagggcggttgtcacaagtatcacaaaatgggtggcttaaagcaacagatatttattcccttttagttctgg
				aagctaaaagtccgaaatcaaggtgtgggcagggccgtgctccctctgaaggtgctaggggagaatgctgcctgcctcttccagcttctggtggctgctgg
				ccacacttggttcaccttagctagtagacacatcactccagtctctgcctccatcctcactcagcactctcccgattgtatctctgcgtctatgtccaaatttccttc
				ttcttttaataacatcagccgttagctttagggcccgctctaatccaatatgacctcatcttaacttgattttacctgcaaagaccctatttccaagtatagccacag
				tgataggtactggggttaggacttcagtatgtctattttggggacacaattcaaccacaacctacagcaaagggtaggtggcctgactgaggtggggtggcc
				gatttgatggtagatccagaaacagaactcacttaggcctgattctggagacttccacagcgtcagtctaatgtgctgagtgccccgcctggaggaaaaattc
				gggcatc
355	3697772	PHLPPL	YES	tcccagcgaatcagtaccgtggatctctcgtgttacagcctcgaggaggttcctgagcatctcttctatagtcaagatattacctacctcaacttgcgacacaac
				ttcatgcagttagaaagacccggaggcctcgatacactctacaa
356	2611934	SLC6A6	YES	gctatgacctcgctggggagctacaacaagt
357	3127807	—	NO	caaggaagcgagtctccgtgacacgtggtacaatatcatgcagtacacacggaaccagaaccaagaagaaatggctggaaaagatgaaagaaaaaaaa
				agttgatatagtctcaaatgtagtgaaaaaacatcaacttatagattcaaaaagttcataaacccctcataaaaataaatgtaaagaaaaccctacctggacaca
				tcatagtcatcatacagagcaaattttgtgcattcacaggtaacaaagatatgaacgacagctgactcaaaacaatggaggctcaggatgtgtgaaatggtga
				aagaaagctgttgactcactattcacactcattgagaatatcctttaaaaatagtaagtgaagacgttgtggcaggttgaactttcc
358	3909039	SPATA2	NO	agggctacatcaaccgacctttcgggtttcacggtgaagaagtactaacgcattgatctcagaggcggaggcctgcacttgaccatgtaggtggcagagat
				cgtgggctggctgtgtccacgtgggagttcacttagcgactcagatatctcaaccaatggctgctttgttgtctgacaagggagaaggtggcacttccgttca
				gattcattttgctaatctctccactccctgttcagttggttctttttttggggttttgttttgttttgttttgttgttttgttttttcctttaaagaggatttctgtctctgggacc
				ctcgctgcacctacccctcccattgcaaagccaacttggactgggaagggcccttcaggtcaccaaacatccacctggagcggcgagctagaggcctgtt
				ggcttgtgaaatgagccctcctgccacacggggcctctcccaaaggctcatcccttggccgcccccttcctaaacacaaggatccccagctggactcccca
				ccccctggcttccccacctctccaggtgtcaaaggtgaaccgagtccagtattagctgaatgtcatttcgtacaccacagctcagtcagcccatggccttcgt
				gaactttgctcc
359	2412620	NRD1	NO	gtttctttgaggaacgcagcctgaa
360	3220615	KIAA0368	YES	gaccctaaactactgtcaatggcatattcag
361	3521230	—	NO	tgctgctgacatcacgggccctgggtt
362	2327492	SNHG3	NO	gacaatctttggcagacttggagcaaaagattgaggtgcatttcatgcctcctt
363	3557645	AP1G2	YES	tgtcaacattcttggtcgcttcctactcaacagtgacagga
364	3709227	—	NO	tgccgtcctcagtgaatcacagcagcttcaaaggactcaactggcaagatttcccacag
365	4021348	ZDHHC9	NO	gagagcaagtaagctgtcccttttaactgtttttctttggtctttagtcacccagttgcacactggcattttcttgctgcaagcttttttaaatttctgaactcaaggca
				gtggcagaagatgtcagtcacctctgataactgg
366	3030989	ZNF862	NO	agggcttgaccctgcctagatcctccttaccaagaaagggctgaaaagagagggcatctggcatgctttttgccacttctgtttctaggttatgtacttcatgga
				atatctgggcattgcttagaaacctgtgtcataaattggctttgggcaagaggctttgagttggaagaaaaggtggaaagaaagtgcttgggggcggagttc
				agggatttgacgggattgccagcgcttccaggccgtgtcatccaagaccagtgtggttgtgggcacattagcttggagacagtggcagcctcttgggacta
				acatcttt
367	3035657	—	NO	agtccggtggcttagatgacaaatggaggtagaggacgcattctcgcctgttatttcgatttttttctctcctcaccctgaccgtcacgttctcaccttttccacctc
				aatccccagtcacactagcttcccaggattaaaatggtctct
368	3626930	—	NO	tgctttcacttaaggcagggctgttgagtcggtgaggggatgagggcatctcaaaagaaggctggctttcaggattgcacagagatgttcctgctcccagca
				gactggggtaaaatttcctgggaatgagggcatttctga
369	3091396	—	NO	caagtgagagtgattttgttacatgggatacattgcatagtagtaaagtctgggcttgtagtgcaaccatcacccgaata
370	3323928	—	NO	cagtgcatcccggaaaaaagagagcaaa
371	3326853	TRIM44	YES	tggccaagaggaagtgtccggaccatgggcttgatttgagtacctattgccag
372	3402333	—	NO	caaagtcctttgcaagtctcacccttaagcgcgtggggactgtgt
373	3796317	—	NO	tcacgttgctggctaccctcatatgtgtgatgactgttagttgtacaattacatttaagaaagaggattacattgctagctggaatttcttctactattataaaaatag
				aactgttttaccaacaagtctcttctccgagtgggacttgatggtaactataactgggatagggcaaatcaacgtcatgggtccacaggttttgctttaa
374	4020467	—	NO	tcccaacaagttgaaccttgcgttacgataaaagcagatgtggcatccaatcctaccacccagcaaagagaaaccccaggcattcaactgcagc
375	3180404	—	NO	catcgctgtgtgcatctaactcttgattcacggtctgaccgacgccttggtttctggagaactgccctcgtttatggaagagtcactgtcatcaggagccatccc
				agggagaggctcagtgggaagtgtaaaggtggagcaagtaaaccggctccagaagagaaggcgaagaaggactatttctgtttagatttgcttaaccgca
				ttttcactttcttgggaacccctgatggagttcaaggtcatagaagagaagaaatcagacactgctacaggactcttgctcttggtt
376	3781848	—	NO	gaggaagtgtctggtccggtccctagagcatggcaggtatgcactcaatgct
377	3868844	KLK11	YES	tcaaggcattatctcctggggccaggatccgtgtgcgatcacccgaaagcctggtgtctacacga
378	2396267	—	NO	tggggacggcaacaccgcgctgcaagtcgttatcattccg
379	2862752	GFM2	YES	tggtggatgtagtaatgaaagaaaa
380	3869672	—	NO	ggagttgcatccttgcttgactaaaatggaagccgtattgattttgaaatgaaaagcttcatgatgtagcatctggactttcactgtcc
381	3876038	PLCB4	NO	taaggatttcaacacacgtaaggccatgtttctgatgttatag
382	3879228	—	NO	ggggagggacatgacttcctgttacgggatgaggaagtagaggttcatggagga
383	2399914	—	NO	ttagacttgaaagaacctcgttcacctgccacatgctatcctagggaattaatagcttcccatgtggacactcactctatgt
384	3142073	—	NO	ggggaacgaagcctgacaactcctaagtttctggcttctacaaccatttagtgaaggtttcattaatggcaggcaggagtacagttttagaaggtctggactgg
				agagacatttgggggaatcatccgtgagtatcgagagttaaagacatgccaggaatagtgtatacaattaaaatagacaggggcttgggaaatgccagttcg
				cagatatatatttgtcataagtgaactaaagaaaaggtatatggttggatgagcttaaacccagcatg
385	3777286	ARHGAP28	NO	cgcagttcatgacttgtaccagtgaaggtagcaaggtctgtgtgttggtgatgaatttgcaggggatcaggctgaagaaacaagacttgggagagaggatgt
				gagacctttttatgacatgcatagagttggcacctcagcctttgcatggtagggagctagctgaaggctacctccatgacagatgtacactttgaaaagacag
				gccgggtgcggtggctcacgtctgtaatcccagcattttgggaggctgaggtgggcaaatcacttgaagtcaggagttagagatcagcctggccaacaca
				gtgaaacctggtctctactaaaaaaaataaaataattagccaggcatggtggcgcacacctgtaatcccaactattcgggaggctgaggcagaagaattgct
				tgaacacgggaggcggaagttgcagtgagctgagatggcaccaccgcactccagcctgggcgacagatcaagactccatctcaaaataaaggaagata
				cagctaatctatatttctttcaccagagatcaccaccactaacaattcatactggtcgtttttccctgaatgttttacctatgtaggaaaattttacatcccaatttttaa
				tttaacactatgaaaagcatttctttttataataaagacactctattagtatacttttgatggcttcaaaactacttttgtatagatgcaaaattaaaatatcaaattgttt
				cttttgtttgtttgtttttttgttttttttttgagacagagtctcactctgtcgcccaggctaaagcacagtggcatgatctcggctcactgcaagcttttcctcccaggt
				taaagtgattctcatgccgcagcctcccgagaagctgggactacaggtgtgcaccaccacccccggctaattttttgtatttttacaaaacacaaagagagac
				ggggtttcaccatgttgggcaggctggtctcaaactcctgacctcaggtgatccgcctgcctcagcctcccaaagtgctggg
386	3851492	—	NO	ttttttacggattcagtgatctggacgggcacatactaccat
387	2712928	—	NO	gtgagtaaaccatggcgtgtttgttggccaaaagccgcaagtctttgaaaaggtgaatcatcacttttccattta
388	3060349	—	NO	ctctggaggcttcttgtcagtactagaaactaatacttggtgaatatccttttctgcttccattaccttgtatgaaactggttccatttatacactgagattagaagca
				ttcataagtgatgcggcaccacaaacacagaagatcaaactactcacagtgtggagaaccatgtcttttataagtgtgatgtgcctaaaaccatcatc
389	3504762	ZDHHC20	YES	aaaccccaaaactgtccaggcatgg
390	3543824	—	NO	agtcttttataagtgttggctatcattttttctcatctatttccttgcttctggttttgcacactttaccatccacactgccatcagagtgatcacacctctcttcagtagc
				tcccatcatctactgcataaagctgagactgttagctagactgttaggcacctttcccacacgatctggctctgccccacttcccagcctcagcccacatggct
				aaacaa
391	3781951	LAMA3	YES	gatttgggcttaccacctactgaccacctccaggcctcatttggatttcagacctttcaacccagtggcatattattagatcatcagac
392	3216926	—	NO	aacactgatctccacgagcacaatcatccaaacggagatgggaacccctgttctaactctctcagaggcctgaa
393	3448246	—	NO	ctctttggtatattattgcagatgttgttatttcacagttaggtaaattagacataaaaaggtcaaacgacttgaacgtgctaccataaaaggtcagtgataaagc
				cagaagtcatttctcagtgtccatcataagccacc
394	2693224	OSBPL11	YES	ggagatggctgggtttatcataaaccactttggaaaataattccaacaacacaaccagcagagtga
395	2672926	SMARCC1	YES	tatgttcatgcggatgctcctaccaataaaacactggctgggctggtggtgcagcttcttcagttccaggaagatgcctttgggaagcatgtcaccaacccgg
				cctt
396	2914136	—	NO	ccatccgttcttttagctgacttgaatgactctaatgcagtgggttgcaggtttggctacttacctatgtactctgtaaacatccagaggcccagggatattctga
				gccactgtgtgtgaatggagtttggccatctgtagatttccgcagtctctccaggtgatcgcactgtgcagcctcattgctc
397	3210858	—	NO	tttgctctgaaaggcagtttctgtataggttcctccgagtgaagatcagaatgttatcagacactggctgtagctcagatgaca
398	3853401	AKAP8L	YES	acttggaactctgggacaaatagag
399	3605225	—	NO	tggacccatctcagcagtgctcaaaccaatgcccaaactctcctgcttaggacacttctccactggccaccctgaggccaccacacctcactggccactcct
				cctctatcttctctgctggctcttcctcctctatggccacctaaaggatgggtgttacacactcaatcct
400	2377461	—	NO	tggagttggccttgttaactattaaacacaaaagcatgtgatagttacctgagagatccatgcaggggagagtccaggggaaggtgactgatcactgcttcc
				cagggggaggcagaaaatgcttcctggaggagatgatgggtggattaaggaagatgagttgagcaggagttgtagctaccagccagggaggaagggta
				ttcagagcagaggaagcaaggtgagcaaaggcaccaagatgtgacactactggactgccaagcta
401	2934549	—	NO	gtgtgctactggcttatggctgatacgtaagagaatctcatctatctctaaatgttctgccttaagccgcacaaagga
402	3185031	—	NO	tggcacatgtggattctataccttaattaaagccactcccttacatacacacatttaggtatcgccagactcgcctgatgaggaataattattctttcctccatattt
				cttaactcctgtcttttccatgaaacggcttggcattaaactccttcccaga
403	3560964	—	NO	gtaatgtggcggtcaaaaccggcgctggaaccacgggacatgtt
404	2732616	MRPL1	YES	aacgtggagccatttaccagtgttcttagtttgccatacccatttgcttccgaaatcaataaagttgctgtatttacagag
405	3150536	—	NO	gccactcattcatggttgttctatgttccatgaactctaatagcccaacttatacatggcactccaaggggatgcttcagccagaaagtaaagggctgaaaaag
				tagaacaatacaaaagccctcgtgtggtgggaactgtggcctcactcttacttgtccttccattcaaaacagtttggcacctttccatgacgaggatctctacag
				gtaggtta
406	3774169	—	NO	atcgctgtaccattctggggcactggagatggcagctgagaagcagagaagctggagacctgaagcctccacccttggctgtggctgccgagagaggcc
				cctgcagagggagccccaggccacacccagacaccacagccagctcacagtgcggccagagggcacaggctgcttggggggtgagggtccccattc
				ctgccacctctcacagaccatgacccacagggctgggggcttcccctgggagaaagtccttccctccccatggcccagccctggggaaagaaagcagag
				actaactcagggactgcagtaggctgaggacaagggaggtgggcttggggtgaaggccccccctcactcgcagagaagggacactaccggcagtaga
				ggacagggaggcaggacgacggcagttagagacgaggcgtttcaggtgaactgtatgtagtgttactccggacgtgagcatggcctgggtcagtcgaat
				gaaatgagctgggcctcgctgccctgtgccggcggcccctgtgcctgcggttgctgggccacggggggctgctgctgggggggaccgccagagggtg
				ccatctgtgcaggaggaaagcaggcatggccctggtcctcccttccccagcccagggaggaaggcttttgtcccagcagagccacagacccacaagtgc
				ttgtaatccatgtccacggactgcagctcatg
407	2987860	—	NO	cccgtgtttcgtgtacaacatatgatacatgtgacagttgacaagagtgcctgagtctcagagcaggaagagttatcctgcctccacatgcattgaagggaat
				atatgtcacacgttactagccaggctcagaggagaacacatctcatttacaagttcaaatctgaaagggagaaatgtgctagtatttagtggatcttgaggaaa
				ctagggatgtgttacccatctgtgcaggaacattagatctagatggggctctcctagtcaaaacgctga
408	3829652	—	NO	atgtgactttacaaccctcggtgtcctcctggctgctgggccccagcctcctgactgttcagctcacacacgtgaacctaacacctgccttggtcccctgctcc
				atcttctagacaactcatgctgaggaccagcccacaggaggaggcctccgagttctctcttgacgtcttcaccttgaccattttttgccaccattttagtctgtcca
				ggc
409	3900228	C20orf74	YES	gaccaaagcctgtgtacattactaccactcgagacaatgagaacatttacagtacaaagattccatatatggcagctcgtgttgtttttattaagtggattgtaac
				cttctttttggaaaaaaagtatctaactgcaacacaaaacactaaaaatggagttgatgtattgcctaaaatc
410	2858280	—	NO	ataaaatacaaactctccaacaagaccttttggccatcaggaacgcagca
411	3088555	ATP6V1B2	YES	aactgcccggttcttcaaatctgac
412	3850502	LOC147727	NO	gactgtttgccaatggttgtatttagtaagatttgtagactctgtttttcttttgacacagctgcaaggccaacagctgtgcaaagccacaagttatgctaagtcag
				cagttatgctatagattacatgacctgtgactgtatcattaactgcttttgttttgcttctgtaagtttgcctataaaaaccacactcagtctttgttcaatggtcagctt
				ttcagatacaaatccactgagccggtgtacatctaaataaa
413	3946288	TNRC6B	YES	tgtggacaagcgagcgatgaatctcggggattttaatgatatcatgaggaaggatcgatctgggttccgtccacctaattccaaagacatgggaaccacaga
				tagtgggcctta
414	3430162	POLR3B	YES	agtctggttgaatatttagatgtgaatgaagaaaatgattgtaacattgcactgtacgaacacacaattaata
415	3751732	—	NO	gaatatgcatctttacaagcatccacag
416	2347259	—	NO	tggctgcctgacattattgggtgct
417	2421262	—	NO	ctccctgcttggcttgatgaccttt
418	3886689	PABPC1L	NO	gtatggtcttgggtttctgctgagaaatggcttgtaggtggggggttaaagttcctcacacctctcctgaacgggaggaagctgctgttcaccagtttccagtg
				ctcaatgcgggcaggtggggcatctgtgcgtttggtaaatacatgatgtt
419	3951993	—	NO	ttgagcccagtggcgggactccacgacgtagacctctctccttctgcc
420	3966982	—	NO	ttcctgctgaccaacctaattctggtttcatacagggcagccaggtgcccacctaaaagactgcacttctcaacttccagttgtttctatggataatggttggaag
				cagaaattgggttggggcttccagataatcccccctcacagggactgcttcaagagaaagggatgccctttggttctttctcctttccactgcctggaatgtgat
				gtctgacactgtggcagccatactggcataatgaggccaactctctgccatgctaagagtggcagagctgggaattgaaaagagcctgctagccttgggtt
				gcttccccttgatcggctcattacttggaa
421	2756515	MFSD7	NO	tgagcgccttgtagtccaggttgcccgccacatcgatggaggcgaactggaacatctggtccacctgcgggcgggggcgaaagggctccttgcgggctc
				cgggagcgaattacaagc
422	3261869	—	NO	tttttgtattctagtcgttcagccccctcccctcccatcttccagcgcttctgaacaactcctactgttctcttcc
423	3391839	—	NO	ccctatagattgtttgaggaccctattaaatattgtatagcctctaggaataagcctttccattgacttgctgtgataaacagatcttttgtcagcgactcttaaaata
				caaaacagccttgggcagtagagtaccac
424	2437406	C1orf104	NO	gcttccctgacctagacagtcctgactgatggtccaacctcaatcccacttatttttggctaggccttcctgggagtcataaaagagatgaatccattctagagg
				tgcacagcctgtctcttccctcacaaatgtcagtccccaagtcattctgatccaccttcctaatatttttgccacctccaacttctttcaagatgaaaaggaaatgt
				agagaagcaaggtcagggtagacacttaatcccactgactgtctttaatccactcttctccctctcaacctggatgatctccacactcctatccatactcagata
				caggatatattgttcccctattatgtgctaagcactttcatatcccttgccttgcttaatctttacagtcctgtgaagtaggaattttatccccagctgaggaaagag
				actgagcgagaccgacttgctcaaggtcacacagtttttcaccaggggtagcagtgttcacg
425	2802671	—	NO	tagagttagagtcagggccctggtccctggtgctctttcctggtcgcttctcatagccaggacgcttgcttacattagttctcaaccccactgggaccaatcatttt
				tattgccaatctattttggggctctgttctcgtggcaataaatcattctttcagagctccctatttaaccttgtgagagcgtgtgtgtgtggtggaggtgcttacata
				aatgcagtatttttaacctgcctggcacgctttaggttggcgtta
426	3415835	ZNF740	NO	aagtagggcacgctctcagagaccaggatagagagtcagggaacctgggaaagagtagtgccagttccgggtaggctgctgcaccaggccctaccagc
				tcaggctataaacagtctgctttgccccaagtttttccgtccacccccaacagccttgtcatcacttagctactgatcacgcccatggcttgacattggagggt
				tacattagtggagtccgccacagcttcgaaccctctccccagatgccctttgcctctgctgtggccctggggttttatcaactg
427	3764797	—	NO	tgggactgtcaatcattggctctgcctctctgaccacagactaaatatatgaccagtctaacctgttaagcataacaatatggacactgggagagaagcctctt
				gaaatcctttgctgaacggatcatgtacaagctgccaagagttcatctc
428	2431813	—	NO	tgatgcacagtttaggagcaggaaagccatgtcttggatccagga
429	2468734	—	NO	tgcccaagtccttgaatcctacagaccttgctaatggctccgttcacgacacccaactggtcctgaactcttaggattaacccgtttgcttatggctgaggaa
430	2512616	—	NO	cctaactaggagagtgttttcaagggagagattgctatagcatcagcctcagggtaggagaatgagcttaaccatgagatttaggtttgagcatgtttactata
				agtaaaaagcattttcctggagtctggcaaatattgtggaagatgtac
431	3242348	—	NO	aagagaatgggcaaagggagcgggtaggatggcggccgcaccaccagccacggactgggagaggcccttctgtgtttccagatgagaagagagctca
				aggaatcccaggaatagactccatggaaaagaatgaaaaaaatcagagaaaagccaaatatccaaaagag
432	3316358	CD151	YES	tgggtgagttcaacgagaagaagacaacatgtggcaccgtttgcctcaagtacctgctgtttacctacaattgctgcttc
433	3473828	TAOK3	NO	tcccactagcgatcagctgacattcctaactgaaggctgcaatgtgttgcttattcattttgtaccgtgggagctgcggggactagcagagagctaaacta
434	2453074	C1orf116	YES	cccggaagctgccacctaatattgttctgaagagcagccgaagcagtttccac
435	3144603	C8orf83	NO	caggaatgcaagcactgctacctaactaaagaccttggctttggaaacatcttaccccttggcagctctccagagtttagacttggcagcatcaaagac
436	3035937	GNA12	NO	agcactcctcccacgggcctgggaaggcaaatgtgttttctgaactgtgttgagaccgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgttggggtgt
				cttgtgaagtcctgctaacctcttgtcagcagaatattcgagaaatgc
437	3854106	C19orf42	NO	cttcaaagtggagtagtggcacagagaccatatggcctgcagaatggaaaatgtcacctgtttggcctcttaccagaaaaatttgccaaccgctcaactagg
				gtgtgatggagaatcccaaggtgtcccttccctcccaaagccactcagggaatcatctgtacc
438	2604179	USP40	YES	ttgcaatggggagtgacgttcaacctgggacagaaatggaaatcgtagtagaagaaacaatatctgt
439	2625696	PDE12	NO	tagtgggacttttaagcatctctgaaataaaaaacttctttttacagacaagcattatagtttgagttacagacaacagtgtgtatatatgtaatatatatatagtaaa
				atgaaatttaaatatgaagccaaactttttaaaattagaaactacaaatggttatactgattagtgtctagcctagagtggtaaccatgctttactaattcagttatg
				aaatacattatttataatgcattagctgtattagctgttgcttttttgatgttcaggataactatgttatctcatttctgcatttaattaatagctcgagtattaaaagccc
				actcccttcaagaaaagctttgattttccccagtcatgaaagcccttgtttcaaattctttaatctctgaacctagtatcataagaatttcctattttgataacatctgta
				ctttcatattctgctcactatcaaatgtattgttaacacttagtaagtttgaaaatgaaggggttttatctgcatttgacattgaaccttgaagtactttaagtactcca
				aggggaaaattaaagtggaagtttcttcggatcttgttta
440	2410545	POMGNT1	YES	catgtggatgcggatgcctgaacaacgccggggccgagagtgcatcatccctgacgtttcccgatcctaccactttggcatcgtcggcctcaacatgaatg
441	2545098	HADHA	NO	atgtgtgtgcagaattctaggcagcaccttagggagggactgggatgagagaaagtgggacctggtgggctcaaccacacacacctgtctgtgcagatgc
				tttgcccaggcttctcaccacggtgtaccgggatatta
442	2749561	ETFDH	YES	atgctggtgccgctagccaagctgtcc
443	2849125	DNAH5	YES	ttcttcggaccttgggagcagcaaaaagagccaatccaatggatacggagtccacgattgtcatgcgtgtactacgggacatgaatctttcta
444	3022356	—	NO	gaacacctgcccaatgtcagctatacttcagctctcatttgcactattcaaacttataaagttgaagagcaacctacgcctgttg
445	2474026	—	NO	gtggtagcagttttccagatgtggatgcttcatgatctggtg
446	3160004	—	NO	tgctttgttgagggtgtaaggggaa
447	3795785	—	NO	aatgggaatgaaatacatgcctttttgtttttaggggtgctcagttataaatatgaaaggctgagaaaatgctaattgtacagtaagatcaactggacttgttttaat
				aagacaataatttgaaattagtaaactattttatacaaatagtgctaaaactttggaaggtcctcaacctcctgg
448	2990169	—	NO	cttgggtatcacacaagcattactgacattgagttcatggaaaatacagaaaatatatacaaaattaatgccacagaacatgacaaatggctgtgaggggag
				gacttttgatcaattgcttgatcttaaacttactttagaagaggtggccagtgcctgccaattggctgccatgtggatacttcttatgcttgatcttaagtgcttttgt
				gtgtgacagctctacacaattccctagttaagagttacttctcaccaaccaaagg
449	3858632	—	NO	gctgactgcagattcaaccttctgagctcacgaa
450	2481311	KLRAQ1	YES	gctgagttgcaggggaagtaccagaagctg
451	3726479	RSAD1	YES	tggccctggggctacgcaccgatgtggggatcactcaccag
452	3847164	—	NO	ccatgcgaagtaccaagccctagttgttctccatccaggaggccgtgtggctcatcccttacccacagaccctcactcaccaccttcgtccctaccatccaca
				gcacccgctggccctgaagtgattccttggtcctggacctggggttttgcattttgtctctgaggaggaggtcgcatggagggggaggggatggggatgtg
				ggtgtatggacgggtggtgggtaggggcacgtctgatccactgtcacggcacctctggtgagttgtaatgcgttcgtgactccaactgactggtcttcaccta
				acctgcttatttctctgccaacacctgggatgggggtttgtaaatccagcagggctca
453	2945519	GPLD1	YES	cttcccatgaccacacacaggagtggggaaaccttacttgtacttcatcggttttcttccaaatcagcgacgggagtaacatttttattcctatcaccaaaccac
				ctgaaaaatggactcctaaacttcctcatatgacatcacattaggctaatcatgtaccctcaatatcatcagggtaagtgtatttattctgttattattacatttgtagt
				gcaagagctggacactctagaatcttccatgcacactactttgggagg
454	2960606	—	NO	ctaaggctggatctccgtttctttccacctgctccaactgtacccacagctgtgtctgactggctgccgtcattatgctccagtgtgtacatctctccactgacact
				ggtgctctt
455	3275073	—	NO	gaggaggttgactcaggagaacttggg
456	3392454	—	NO	gatgctgaattgaactgggatcttcttgtctgtcaagcccttgaacagctttccctttaagcaacaaagatgacaagtttttgctattttggattagtgagagtgtac
				gaaatggtttccctttccttccaggcaaaaataccaacagaatctggcttcggaatgaaagtgctaatttcatttggtgactttcagatttgaaatacgggcttga
				acaggcattgtgcattagtcagctgaggcagtggaggttatttttacgatgctaattattatttcctgacagtgatttactttatgttgtctactgttttacgcccccaa
				actagccattgttttaggaacagaattggttgggttgtcatgctcttttcaaagacaaatcttactattttatgcatagaaatactttcctgtaataaagaagaaagct
				ttattgaagagaatcttgcatatgaaatgtaatctggataaatattcaaaactaataggtttatattttagtcttgatttttaaagtatatttttctgacatcctaaccacc
				ttgctttatgtgcattaaagttaaatctgttttactgggatgcggctgaat
457	3428624	MYBPC1	YES	catttgagatgcagatcatcaaggccaaagataactttgcaggaaattacagatgcgaggtcacctataaggataagtttgacagctg
458	3869530	—	NO	ccattacagcagcaggatccagtgacccgggatgctcacatctctccctgacgtgggcggagtagccccttcctcccaaggtcactgtcctgtccaacccc
				gtgctcccctagcccgttgggaggtggacagtgagacatcttccca
459	3180781	—	NO	tattgggagtcctgtcagaagctgcctgctacagggtctttagctttccttagattttcaaagaggtttgtgatccaagaagaatagagttttgaatctagattttat
				actaaacgatcactttagattttcaggagtgtgtgcctagtttgtgattaagtta
460	3319155	PPFIBP2	YES	ccacagtgctgctagtaatgaaacctaccaggaacgcttggcacgtctagaaggggataaggagtccctcatattgca
461	3428631	MYBPC1	YES	cttgatcctgcatatcaggttgacaaaggaggcagagtgaggtttgttgtggagctggcagatccaaagttggaggtgaaatggtataaaaatggtcaagaa
				attcgacccagtaccaa
462	3435265	LRRC43	YES	agccgaaagccgtgattccgatctacgaaggcgattaccaccctgagcccctgaccgtagaggtgcagatccagctgaaccagtgccgctcggcggagg
				aggctctgcgcatgttcgccgt
463	3697431	—	NO	ggaaagcggggcagacaaagtatccaaaagt
464	3928125	—	NO	gggcactcacccaagtaatgtccaaacaatatttttccatgtcccccctcccccagaacacacacaggcaaaggcagagatgtttactgtgaggtcacatgg
				catgaagcaaatgcagccttatctgtttattattacaacagccagttagcattggcaaatgtgctttggttacaaacatggtttctgctaataatttcatgaagaag
				cttttaggatatgtgaccatttattcttagtataatcaatcattgaaggataaaaatcagagtataaaagtttatactctggcaaatataaatacatgcacagaagttt
				ctgacagtttaaatttgagcatatttgaaatattaaaggcatgaaatttaaaaatacacatacgtgaaactatggtgaacatgttatgggtttgtcccatggtttaac
				tctgctcagcccacgattcttagctgggtcagtcaatagtctatttttatcattttctaccctgttgtacagcatgatcatatc
465	2769166	—	NO	gtggggtcagagaagatattaggaaa
466	3545551	C14orf178	NO	tggcgcatatcagcagacggcggtcactactgtggctcatttaaatctgtgttcagctccgggcctcttttttcaggaatccttgtttcgggacacccagtggaca
467	3899443	—	NO	gacttacctggagagcgcgagaactggtgtagcttacgtggagtgagaagagatggggaacatgtgaatgaggtcagagcggttgcaggaaacggactg
				ctgctgtaggccattttaaagacttttgattttcctctgaactgccgagtattttcagcagaggagtaacatgatctcacttatttttaacgggcttactctggctgc
468	3182036	—	NO	aagattgaggagaagagtagtgacaa
469	3063084	—	NO	gagctgggtacagagtgcttcatgctgagcctccgggcatgcttcgtgtacactccgcacactctccacacacacacgttacatggcagcagtcc
470	3387617	MAML2	NO	gaaagcctgtgtatcgccgtgactccgggcgcgagccagtgtcagcaaagcggctaacaacagacgagaaagagaaaggaaaatacaagctacttttttt
				ttccatctataaagcggagcaaatacaggagatagaaccagattgcttattgcgagtccagaccctcagatccactggccggggatggaatgtacaaaagt
				ggacagaaaagtggctggacatgactcggtgcaatttgctggaagtttgtaagtttgaccatcgtttgtaaattactctcggaagagtttgtctctcttgatactgt
				attagaatagagccgggggtgaggaatagaaacgtaagcgggaaagaaaaaaatgtgttgaaggatctctctcagtggctagcga
471	3566496	—	NO	cctaagtcacgcctctggaactttggcaagttctatagaagagtcagcagcaggtgtgggtcaaggtcccaattcacttcctgcagctgtaccatcccttcctc
				gttctgcaaattttctcta
472	3088581	—	NO	tgatctcatgatctcaaaacaaaggg
473	3120740	—	NO	gagcttggtttttggtcagaagccaagaaaaaagatcggagaagaaaagaaggaatgacctcaacttgctctgcacggaggacggggacggctcagaga
				taaatagc
474	3399570	NCAPD3	YES	cctggacgccagtgagttactctcagacacgtttgaggtcctcagctcaaaggagatcaagcttttg
475	4010188	SPIN3	NO	tgtatcaaagtaatgtgtccaccggtgtgagcaccagcaactcacttcttcctcagacatctctaaagctggaaagattttgagggacaatatggtttccttcac
				cccacaccaatgttatgaatgagaccagcagaccaacagcaaacacctaga
476	2638236	—	NO	tcagctctgcagccctacagttaccagctaaccttg
477	3683253	—	NO	tgaatgaatatggtccctggggctaaaagtaagaaaggagaaaaaaataaagcaacccccaaatttgatgagaaccctatagtccctgactgattgtttcctg
				gccatcatcatcatcagcttcaactttgtcaacacacccttaatatgggtgtaccttgttttacagtttgccgagcactttcacacccattattggatatgacacaca
				acccggtgagagtgctctc
478	2502720	MARCO	NO	ttcacttctctgctcccgaggtgtcctcgggctcatatgtgggaaggcagaggatctctgaggagttccctggggacaactgagcagcctctggagagggg
				ccattaataaagctcaacatca
479	3378495	—	NO	aaaactgccctggaggatcggcacg
480	2642712	—	NO	atcattttgctcaggccacggccact
481	2798891	—	NO	catttcccagtgctgtatactcctatctcccagtgctgtttgctcccatttccca
482	3428610	MYBPC1	YES	agagaaggaggccggaactacaccagcaaaag
483	3691119	—	NO	ggtctcgcgcgccgtcttctcgagag
484	3821139	LOC126075	YES	agaccattgtgatgattcccgactcccagaagctcctgcgatgtgaacttgagtcactcaa
485	2349300	—	NO	gagaattgggaatcaagaatcagccctgtttccatcttagccacaccaacttatatctttatgattttcaaagcttttgccatgtgattctgcccccacaaaggcat
				cggtatttccta
486	2638933	—	NO	tgcggatctccaaagcctagggatttttccgtaaaagagagtgggccgttctggttacccttttattagaagggtattccaccacagagagccggaggttttcc
				agatgtgtgtaagagagcaggtgcgcaaggcaagcaaatgagcgcaaacagtattatggaaaacatttgagaagttagctccatgaggactgtgggctcc
				acaagaggactcgactgggtagcctggtctgacacaggtacgtgaaagcagagtattgcttcaaagctggaaaccttccataggagcctcacactgttgga
				agatgtactgctgctggttaaggtcaacctggggtgcaatgctgctgtcttcatcttcggtcccgaagtaatgctcaataagatcaaaggccttttggtagatct
				cctg
487	2661085	—	NO	ttcctcacaaactggccttccatttccagcagaggcaaatcaaattgccttttccgccctcatctctttg
488	3037551	—	YES	ggcagtgaggagatcggtaacttgggagt
489	3215176	—	NO	tggccgtctgtacagaacccacctgcaaccaccacaccctgagcccatgtggccgtctcacctctaagtcacccaa
490	3410744	DNM1L	YES	gcattacaaggagccagtcaaattattgctgaaatccgggagactcatctttggtga
491	3439960	—	NO	cagagcgccagcaagcggccacagaa
492	3461262	—	NO	tcattttaactctgtgcagagtatcaaatccatccatt
493	2316284	—	NO	atgccaacgccgacgtccctgcgggg
494	3882865	—	NO	tcctagcagcacacatatgcagctctt
495	3685651	—	NO	aggggagcttcgtgatcctgtgcaccaagtctccatgccccttgttgtacccagagcaccatgctccccgccagccccctgtccacccctgcttagttataca
				gccattgtccgttttgtgtagaacagtggctttcaagcttttgtcaccatgatccatattttaaattgcaaccctgttccctatgatacct
496	2854135	—	NO	ccgaggactgttgaattgtggaacatctggtggaaaatagcaagaggtgacagaaatgctaatggggcagtgagatgtagacttcaggcagaattgttgtac
				ctgtcgagttggag
497	3314277	—	NO	gtctaaggaaaacaacaggctgcgcgaaatcagccctcagggtaacactgaacctggcgctcttccggcaccacacaggaggcgacgcccgggaaag
				aagactgagcggctcctgtctgaagacgtctccatcagtccagcca
498	3724236	NSF	YES	tgatggcgtggagcagctaaacaacatcct
499	3746906	NCOR1	YES	cacaggtatgaaacacctagcgatgctattgaggtgataagtcctgccagctcacctgcgccaccccaggagaaactgcagacctatcagccagaggttgt
				taaggcaaatcaagcggaaa
500	3909730	ATP9A	YES	gaccacttcagattcgatcgtatgtgtacgcagaagagccaaatattgacattcacaacttc
501	3428460	UTP20	YES	ttggttgtacagttggcacgagatctgcagatggatttctacccacactttccagagttttttttgactatcacctcgatcctggagactcaggacacagagttgtt
				agaatgggctttcacctcgttatcatatc
502	2751975	GALNT7	YES	gggattatttgccattgaacgagagttcttctttgaattgggtctctatgatccaggtctccagatttggggtg
503	3894100	C20orf96	NO	tcccagcacctggagccttggatcatttacttccaggaccggatctccattcagaccctgatctacagtctccctgctccctctgcccttcctccctctttctttcc
				ctccctccctccctcccttcttccccccttcccttccctcctccttccttcctcctctccctccctccctcctttctttcttcctgtggttttttcctctcttcttcccttcttt
				ctggttggtgctgctgggccaggtgggaatttctgatta
504	3908236	—	NO	accttcagggtgctttcacaaatgagctactggagtatttttcgtatctttggttgatgaaaaggctcatctccaaacttaatggttgtaccaaggtgttttcattcct
				tcaacaagtcactgagtgctttcttggaacacacagccttgcactgggggttatggggagggaggaagaggctggacagggttactgcatactgccggaa
				ggagattctcatttggctgcagagtgtcgcaca
505	2407923	—	NO	gaggtctcccgtcactgggcatccagctgggtgctacggccgtggctcctgccttctgcagccctgtcagggcccaaggccttcctcatcagcacttgctcc
				agcctactcactggagttgtgttctgggtgggtgtgtagaatactcgcactcctacttggggcatcagggagctctctagcaatttc
506	2571603	—	NO	ttggaagctaacctgccacattgacttaactgagtgaccccagttccaaggcagggcctctacaatttccagtttatctattgtttcctgtgtaagagcagatact
				tactgtaagtccgtaagtgctactcgtaggtcaaacaaccttgatgatatcacacttcaattgtcttataaatcccatctgaaccactcctaccctatggtatatga
				gccctgggtttgggtgctaatgcggggatccaccatctcatctcattgccgcctgagacacctacatggctt
507	3634205	—	NO	agcagatgtcagcatccgggtcacctag
508	3746967	NCOR1	YES	ccactgtataaccagccatcagataccaaggtgtaccatgagaacatcaagac
509	3675286	WDR24	NO	ccgcctggtcttgtgcccgagacgggcggaggctggaacttgagacctcaataaaggaagtagag
510	3809651	FECH	YES	agctggcaccattcatcgccaaacgccgaacccccaagattcaagagcagtaccgcaggattggaggcggatcccccatcaagatatgg
511	2793478	AADAT	YES	catattgagcagaggaccaaaatcgatgatctccttggctggtggcttaccaaatcca
512	3139792	—	NO	tgtgtcacttctgcattgcccagtattttgagttgggggaaaaatgaactcacctggccccacctcctgttccagtgtgaaatactgacacttgctgccagccca
				gcctcctcacataagcattagaaatatcagacagtccactaggttagagcacctcattcatgaggttctgttatttattcggctctcccactaaaatgcagggcat
				aaatttatgtgtctgctctaagactgcagctgtctgccccccctccaccctcctcctgcccttcctgtgtcagtgttacattcgctccccccacttttggtctcaggt
				ctgtctcctttttgtttttatgggtgatttgcagtgattcagacagggcatccttgcatgttggcacttcctggaggttaccaggaggcagccatccttccttggctt
				ggccaggcatccccgactccaccccactttccccttggtggtggaaaggtgggttggaggtgtgtactggggcacatagcccaggaatgttgctctgagaa
				gaggacatgtgcagtagacacaaaaatataaggaagcaattatgttcatcaagccgaaagttgcagattttgaggaaatgtgtttagataccactacataata
				aaagggaaaaccacttggcatttaaataacttacttcaagaggaaattatgatattttcagtctacaaatagagtggtttttaagccaaccttgagtaggtacaag
				caaattataaacagtctgctcaaatgattttactatacttagactagaaaatggctcctcttctctctccctctggtccctatgtcccagtgctgtccctcatatgtta
				caa
513	3296171	—	NO	acatggctctggtcgaaatgtgactgaagctttgcat
514	3470058	PRDM4	YES	cttatttagctgacagaccacctcc
515	2830812	—	NO	tgggtaacagaacgcaactttgtctccaaaaaataaataaataaattgttacaatgaaagtggctctgtgttagccgggagtgg
516	3151504	—	NO	cttagggaatctgtttcggtggctcagagaaggatctgttgccaatcagccgatgccaggtctccggtgct
517	2978822	—	NO	ggcaggtccaggaactgggtctggagccttgaaagcagaag
518	3432174	—	NO	gtgcgatggaaaaggtatccaaagtgatactccctttgactctgagcatcagttgcccgtgtttcagtcacttcaa
519	3922854	PDE9A	YES	gaccaactgcccctgtaagtacagttttttggataaccacaagaagttgactcctcgacgcgatgttcccacttaccc
520	3225896	—	NO	ctggatctgccacctcttctttcggctgtggatggccctgggagacacgcctggcctcagatgccccttgacccaactggaggaagggtggggggcccag
				cagaaaagcctgcagcctccctgggcaccgtttcaaagctgatgctgctctccctgctctgggtctcagctcctcccctcttctgcattgttgaccaacagcct
				gggtctgacgcggaagcagaagaattcc
521	3981141	OGT	YES	aatcacgcagtggtgcacggcaacctggcttgtgtatactatgagcaaggcctgatagatctggcaatagacacctacaggcgggctatcgaactaca
522	3040366	TWIST1	NO	cctctgcattctgatagaagtctgaacagttgtttgtgttttttttttttttttttttgacgaagaatgtttttatttttatttttttcatgcatgcattctcaagaggtcgtgcc
				aatcagccactgaaaggaaaggcatcactatggactttctctattttaaaatggtaacaatcagaggaactataagaacacctttagaaataaaaatactggga
				tcaaactggcctgcaaaaccatagtcagttaattctttttttcatccttcctctgaggggaaaaacaaaaaaaaacttaaaatacaaaaaacaacattctatttattt
				attgaggacccatggtaaaatgcaaatagatccggtgtctaaatgcattcata
523	3847114	PTPRS	YES	gagtaccagttctgttaccaggcggcactggag
524	3903914	—	YES	aattccagagaagggtttgagtttggagttttatctgttgtaaaatggccctgcttttag
525	2545695	GTF3C2	YES	attcattatattgacgctggttaccttggtttcaaggcctacttcactgctcc
526	2468742	—	NO	ggaggttcgttcataacacaccctagaaaccatgaaaaacatggagagccaagtggagtgagtgacccgagtttacaaagcctgcaatgatcattcttttatt
				acctgacaggatttagggtaactagaaaaacaaatacaacttatcttaggcaatcacttctctatgatctcagggaggctata
527	3332623	TMEM109	NO	ctgtctggggttggctctcttaaccctttctctgctcccagcctgcctcaccagggaaggttggaggggcctccctctggcttctgcatctgcgccagcaaac
				atcactgccgttggtctctcatgacttaactggcttccctctgctgctgccttggcttcctcctaatgctcgtgctctcctgtccttctgaagttgctccttggccaa
				atctccagct
528	3457669	—	NO	ggctttatcggatagggacagacgaggtaaggaaggttgtttaatgagaggccttgcttgccagcctaagcttttaaatttgatgccagtggcaacaataaag
				tgta
529	3575429	EML5	YES	gtggcagagatggttgtattcgtctttgggattta
530	3676065	—	NO	atgggggacgaatgccggctggattcaag
531	3541353	PLEKHH1	NO	gggccctgcccagataaaattgttggtcttgtctgtaattagtattccaaaggttcaggtggtgttgcatctccgtatcaatgttcagctagtaggtaaagggaca
				tatttggagggaactaactctggcctagctactattatgctcttcactttttcttttttattctctcaagccccagcatcatgcagtcctcagttgggtgcttacgtgct
				cttctcttccttgcagcagtcctcaaggcagggcagattcctctttaaggtgctcgcatgttacccctgggttctgctgacccaacattagctacaaagtgggac
				agtcccacagtgctccctcttccttgttgtggggaagaccgcaaaaagacctcttttgctttagtgactttgttcctactcaatacaggaagtgttgaccagcaaa
				aataataattacaaaggctaagttctgatttattgttcctgactcccgtgtgattaactggaaaccctg
532	2428388	—	NO	tggagctctccaaattaagaatgggtagtgacaaactttgaacaggtaacaaacaataaattcaaagtatatttaggattaaacagtcaatttctaaatgggagt
				ctatcatgtctcccctttgcaatactggccttcccaacaggaattctatacttgtccagtccaccataatgggta
533	2883068	—	NO	tttctatctcttcaccttacacacac
534	3686201	GTF3C1	YES	agggctcgattccagcttctacggacacctcaagcgcaactggatctggaccagctacatcatcaaccaggccaaaa
535	2933137	—	NO	atgagcaaggctggtatctggagttttgataaagt
536	3098268	—	NO	agcctcagattctaccgaggcaggcgccccaaataccctccggacgctggcagcagttgcgtgcttcatctgtcct
537	3804158	—	NO	cagtgtgccattgtaatttattggtggagtgctatcattggtaacaatatcatataaatgtatttaacccctcctagcttttgaagtaagattcatgttagagctagaa
				tttgtctgggtgc
538	3570485	—	NO	tggaggggcaggattacacactgaatcattggca
539	3666058	—	NO	ctcttggcttcaagtgattgatcctcccacctcagcctcccaaaatgctggaattacagacgtgagccactgtgcccagccagctcatcttcgaataataacag
				ttttacttcttccttcttaatttttatactttttcccccctttttcttgcttcattgtattgactaggatttctgatacattgttgattagaggtggtgatggaggacatccttg
				tctttttcccaaactcagggcaaaaaaggattcatagttgtgccattaagtaatttgctagggtttg
540	3692317	—	NO	acaatgtggctgtgtttgatcccgcgacgtgtcacttggaatctcaatttattgccaatagacgacgttgtcaggcactaattttctggtggcgctccatc
541	3749798	MGC33894	NO	tcgggggtcacaagccaaagccacaccgctagaagggctcaggacccagcccagctcccgtcctcttggtggcatcaagcttgtgtgatatgaggtcttat
				gtc
542	3965785	MAPK11	NO	atggagctgatccagtaacctcggagacgggaccctgcccagagctgagttgggggtgtggctctgccctggaaagggggtgacctcttgcctcgaggg
				gcccagggaagcctgggtgtcaagtgcctgcaccaggggtgcacaata
543	4051547	LOC100129722	NO	tgaccttggcccagaatccaccagggcagggcctgtgaacagggccaacttggggccctcctccgccctctctggatgcctccccttcagcactgggcct
				gccaggcagacagatggacacgtgcttgaggaaacacgggttttatctgggcgaggggttcacgcctgtgctccggggcccctgcccaggttgtgccgg
				gttcagagttgactggctgccagtggaacagagtgtactttgctaatgaagcccttgtcattggacagataggctcctccaggtcctccctgccctgtaataaa
				cgttgccaccg
544	2849256	—	NO	aagacaggctggtgctttcaaaatcagtattttattgtgaggtcaagcagaaatgtactagcagcacaaccacagatgacacttgtttggcttaaaacaagaca
				caca
545	3166772	—	NO	tttcttgtctcttgagtggcggatcatgcgacacctcccgaccacagcatttgggcgagatatagacatgcctctaaa
546	3886907	PIGT	YES	acaacgagacattagaggtgcacccacccccgaccactacatatcaggacgtcatcctaggcactcggaagacctatgccatctatgacttgcttgacaccg
547	2474079	—	NO	agggcacagagagttcaacaaacactgaaacttaagtttgtcctggacatcttcagcatccgactttctggtggaaag
548	2661946	—	NO	gccatcttcctatcctggtcctgat
549	2963039	—	NO	ttggtctctatctgggcacagtctctttggtactgtgtgttaggactagatgtttttaacatgaatgaaaacgtggactcaaaagaaacacttttcaggtgtctataa
				atcttcttattttcaagtttacttagtatttggtcctggggtgtctacatgtcactcagttttgaggaaaaaatgagatgaccttagaaataacatagaaattaatgtg
				attgatgaatatccttagaaatttaatgagatttatacttggaatatggcaattacaatattttattgaaaaatgaataggtcaccagcctggcc
550	2991676	TWIST1	NO	tgaatgcatttagacaccggatctatttgcattttaccatgggtcctcaataaataaatagaatgttgttttttgtattttaagtttttttttgtttttcccctcagaggaag
				gatgaaaaaaagaattaactgactatggttttgcaggccagtttgatcccagtatttttatttctaaaggtgttcttatagttcctctgattgttaccattttaaaatag
				agaaagtccatagtgatgcctttcctttcagtggctgattggcacgacctcttgaga
551	3535849	—	NO	ctgaatgctacaacctcggagagagaataggggagtgttggtgtttgtggtgaatcggaaagcacgtgtttaaagaggacaatcacattaattcagttccagc
				tatgagattacattgtcaaatcatctgatttttcaagagaaatcacaaatttgaatttcttaaaatgagaaatctactttttaaataatgacgggattttcaagtatgtta
				aaaatactgtaggctaataccgaataagctaagcaaaacttttgtggatcaaaccgaaaccatgggctattttcttctcctcctcttcctcctccttctcataggaa
				taaaacaactaaatataatcctgtctttataatttccatataccaagctttaattatatttaatacccatcaaagttagttaaaatgaactctgagtaatttataccttat
				ggaaaaattacggtgttctaagtctgaccaaatgtgtagaaagtacc
552	2488753	CCT7	YES	agccagctatggtgcggatcaatgcgctgacagcagcctctgaggctgcgtgcctgatcgtgtctgtagatgaaaccatcaagaacccccgctcgactgtg
				gatgctcccacag
553	2575232	SAP130	YES	gtgatgtccagttctaaagtaaccacagtcctgaggccgacctcacagctgccaaatgctgctactgctcagccagcagtacagcacatcattcaccaac
554	3076375	BRAF	YES	cacgccaagtcaatcatccacagagac
555	3187656	CEP110	YES	aatttgcagcagatatcccagcagcagaaaggggaaatagagtggcagaagcagctccttgagagggataaacgagaaatagaacgaatgactgctgag
				tcccgagctttacaatcgtgtgttga
556	3286398	ZNF32	YES	actgaagcccaccacaaatatgaccactct
557	3840338	ZNF808	NO	acagatgtcggccactttcgccatcctgttttttgt
558	4019888	—	NO	ggaacagagtgtgccagaaccctcagggtgtttctcagctcttgtttacgggccaccag
559	3831504	—	NO	tggtttgcgaatatgctcaagtctctggatgaattgtatgacagtgaaggggtatgtgattagactgttgtggctttgaggttgatgtgtatgttttaaaggattatg
				attgagttggagatca
560	2540638	—	NO	ctccttctatcccaatcggacagtgatatgaccctggggatgttccatgaatcatttgttcctctttggccccatctgattgtgtacttatctccttacacagtccttc
				tgaccttgaaatgatccagaaaagatgtaaaagagtaaattctatagtcagtttaaaaggcagcaggaaaggattgggaagcattttggacaaggggtctag
				gagacaggcccagctctgcacttttccgtgggacaaaggcctttgcattctctcctgta
561	3229612	UBAC1	YES	acgaggatgagcgtgtggacgaggctgccctgcggcagctcacggagatgggctttccggagaacagagc
562	3839570	KLK2	YES	ctcatccagtctcggattgtgggaggctgggagtgtgagaagcattcccaaccctggcaggtggctgtgtacagtcatggatgggcacactgtgggggtgt
				cctggtgcacccccagtgggtgctcacagctgcccattgcctaaagaa
563	2380069	KCTD3	YES	ggcagcaagtgtttacgagcccatatttggattggactatcgaacgagtagctttaaatgcaaaggtggttggagggccacatggagacaaagacaaaatg
				gttgctgttgcctcagagagtagcatcatcttg
564	3428646	MYBPC1	YES	tctgattgacaagacgaagttcaccatcacaggtctgccaac
565	2998434	RALA	NO	agtaactgtccgctagaagtctgtccaaatttaaaatgtgtgccatattctggttcttgaaaataagattccagagctctttgatcgcttttaataaactgcaagttc
				attttaaatgaagggccagcatatatacttgcaagataattttcagctgcaaggattcagcaccagttatgtttgaatgaaccctccttttctctgagattctggtcc
				ctggaaatccctttctgctagtggtgagcatgtaagtgttaagtttttaatctgggagcagggcataggaagaaaatgtcagtagtgctaatgcattttgcacta
				gaacgcttcgggaaaatattcatgcttgccatctgttcatttctaaatttatattcataaagttacagtttgatacaggaattattaggagtaattcttttctgtttctgtt
				tataatgaagaacactgtagctacattttcagaagttaacatcaagccatcaaacctgggtatagtgcagaaaacgtggcacacactgaccacacattaggct
				gtgtcaccattgtgtggtgtacctgctggaagaattctagcatgctacttggggacataatttcagtgggaaatatgccactgaccgattttttttttttcctctttgc
				agtggggctaggacagttgattcaacaaagtatttttttcttttttctcagtcctaatttgaacaggtcaaagatgtgttcaggcattccaggtaacaggtgtgtatg
				taaagttaaaaataggctttttaggaactcactctttagatatttacatccagcttctcatgttaaatatttgtccttaaagggtttgagatgtacatctttcatttcgtat
				ttctcataggctatgccatgtgcggaattcaagttacc
566	3544955	—	NO	gctttctcctcttccgggtcttggactg
567	2981913	EZR	NO	cagctaagatgccatgtgcaggtggattccatgccgcagacatgaaat
568	3013230	CASD1	NO	agactgtctgcacctgtattcattgtggaacttcctctttcattggaaactttcttactcaagaatgacggcagtattgttttcttatatgtgcaatgaagtggaatga
				taaacagtatgcctttaatttatatgtgttcttgttctgatgttgtttcctgaaatgatttttcttcctaactgtggttttcgggtatgcaagcctaaatctttgtacactttg
				tctcacagaatagttctgaggctccatgacagggttttgtcattgttgatgttattgttgcttcgttttataaaaaagccaaaattttttttccaatccaaacgttcacct
				gtttcctttcctcaagctataccagtgtaataccagttaccctgtggatccatttaa
569	3739279	—	NO	gtggcagtatctgtgacgatgggaagt
570	2409084	—	NO	agattttttgccactgccttgaggatccctgattcctattgattttacctgcccttggacctgtccacctctatcttcacctccacctccctgatccggtctctaatca
				actctcacctggacaacagaaatggcagcccaaattgtctcccacat
571	2848243	—	NO	tccacaggactagctggcagatctaacgttggggagagagacaaaggtggggtcacaggcagccccagcgtgttggcccaagttactggaagtttggag
				ttgccttgggaagtggaagcttgtgtctagcaccttagaccaccgggccatcctgccacacgcttggagttgctttgaactatgctggggaaggtgcaggcg
				gagctggctgggaaagtcagcatgggcatgtgaagtttgggtgtacatgacatcaggctggcagtggtgggtgagaaggagtctggggttcgggccaga
				gggtgggctggagatgtaggtttgttgggcatccgcacagatggagcctgggagtagctgagactccatggggagcacgaggatgagctgttgaaggca
				tgagctctggaccctggcattagaggtctaggaaattaggggcaaccagtaggacttgagaggggagcctggggaggaggaagtgccaggagtgagtt
				acactggcggcccagtgaaaccggggttcctggggggcgggatgtgtgtgtgtggcagggctgggttatcttatacctttcagaactatgtttaaagttttgta
				gatgtaattagaataggatgagttcatgccactttgaaacctataattgtatgaataattttgaattcattacgcagacatgacacatcacggcttctctttgcgtat
				gatatca
572	3775781	—	NO	tgactgagctgtggaccgcaagcagtggcagccccttggctgctcgctattttgagtctggagagattgttcacgaggagcacaggctgtttggcaacatca
				gagct
573	3990538	—	NO	ctgggtagtctacgagaaatgtcaattattatctctactacaactacttacatatatctaatgggaaaagagtggggcttaggtgtcagagtggatgggagaca
				aaggagaagctacactaataaatacaacaagtggaaggtacctgtcccattcctaaaaggatttgtgggcaatgctggcacttggtggccaggagaatcttc
				tgaccccactctccctcctcttcagtcctgaagaccccaagaacccagttaggatcccctggccagaggtctctgtgactgcctctggactcagcacgtgca
				gcagcttgggaggatttgagccagtctcaaaaacttttagccccagaatgagaccagtgaccccaagcaggagggctgggatctggagggaagagagg
				gggtccaaggggaccctgtggctgaggccatggagaaccagtgccagggcccaagagacccatttttccagttatcagaggtgactgacatcttctgcca
				ctgccttgagttcagaaatttaaaaaagcttgcagcaagaaaatgccagtgtgcaactgggtgactaaagacca
574	2411004	KIAA0494	NO	ggactgacgcgttcccactttcttactctgcacctccccactctcttcccattcaagaacgagtttctcttccctctccattggaaatcttgctccggaggtccgaa
				acacgtattttaagcgtgcccttcctcacctcctggagcacccttagaagtattgcctacttatccgggctgagaatccttcatttttgacctggcttttttttcgccc
				tttgggagataaaggtccctctccaccctctactaacactctgcacccaaggccttatcctttggggtcaccag
575	2642748	—	NO	acaggggcgcatttgcctcacaaggaacatttggcaatgtcgggagatattctgggttatacaagtgggagattaggaatgctactggcatctagtgggcag
				aggccaggatactgtgaaacatcctataatgcacaggagagctccctacaacaaacaatt
576	2661956	—	NO	atggacacccactttccatgcttag
577	3307945	—	NO	aaaatccagtcccaactgcagatccctatgcactcccccaac
578	3789999	—	NO	ctctcttcttgtggtaggtcccagaaacttctacttgggggtacatgaggcccagctgggattgggcacagaaggtcatggctctgcacctgaccctcacctt
				aggggtcaggagagagccaaggacacgagtgatgggttagggaggactcaggcaccatggaatactgtggccatccttccatagaggagaggtacagg
				tg
579	3963093	EFCAB6	YES	atggcgattataccagactggcttaggtcgcatcctcacacacgaaaatttacacattcaagaccccattcttcaccgtgtagagtatattca
580	3589632	EIF2AK4	YES	cagagaagctgacgaggagagaagt
581	3816037	—	NO	tttccatcacccagcaaacgccgtcccgcagcacccgggaagctgcggagtcgggctggggccgccgcgttgcgcacatcggtccttg
582	3417925	LRP1	YES	cggtgaattcctcttgccgagcacaagatgagtttgagtgtgccaatggcgagtgcatcaacttcagcctgacctgcgacggcgtcccccactgcaaggac
				aagtccgatgagaagccatc
583	3696235	RBM35B	YES	acccgctgatgactacaccagtctgatgcctgttggtgacccacctcgcactgtgttacaagcccccaagga
584	3462998	OSBPL8	YES	aagaagcttatccaacgccaaccaaagatttgcatcagccatctcttagtccagcaagtcct
585	3962740	TTLL1	YES	ctttgaatgctatggctacgacatcatcatcgacgacaagctgaagccctg
586	2681997	—	NO	cccagagcgagacgactattccatggccctgagcagacaatttctcttttaaaaatggtggccctttaatgatgttattatgaggtttttaaatgacatatcaaaa
				gttgtttatatcacaaaaacccaacagtcatttaattatactaatgaaggtctttatacgtgtcagattttttaaaaaagacttctaatggccatgagaaatggactg
				ttgctgctgcttgcatcacagcagtggtggcagcattctttgtagaggaagaacatattttataatgtataagggaatttgcatttcgcttttcacggcaaacctttc
				tgtgttttttgtaaatctaacaattgcaacaacatggaatatttagttgggagatgtttggagtaagtgttgaaagcaactatgtttgcttgcttttttttttttatggtta
				gagaacaactgtggcgactttcacagattgaactagtacagttcaaaggaaaatcatcgactttagcacatctgatagctatataggcatggcagaggtgtctt
				gaaaaaac
587	2743344	PHF17	YES	ggtcctagaggaatttgagcagcgatgctacgacaatatgaatcatgccatagagactgaggaaggcctggggatcgaatatgatgaagatgttgtctgtga
				tgtctgccagtctcctgatggtgaggacggcaatga
588	2992873	—	NO	ttcccaagcactgtacggggtattgggaaggtaagaacaaaaaagatgtagtccttgcccttacaggtctagttgaggaaagaaagggggattgttttccagt
				tgcactgaatatgaatcagaatgaggaagaaagtacttggaagcctctagctgactctggtaccattccacggggccatgatacctttcttagtc
589	3568027	—	NO	acatattttatgctatgccctgggggtaaagggtgactaagacgtgtaaggcacttgcattctacaggccattgcttttcatgggtataggttttctctccccagtt
				agactgtaagccttgttt
590	3830188	FXYD3	NO	ctggagacttcctatgtgtgcattggggtggggcttggggcaccatgagaaggttggcgtgccctggaggctgacacagaggctggcactgagcctgctt
				gttgggaaaagcccacaggcctgttcccttgtggcttgggacatggcacaggcccgccctctgcctcctcagccatgggaacctcatatgcaatttgggattt
				actagtagccaaaaggaatgaaagagagctctaaccagatggaacactggaacattccagtggaccctggaccattccaggaaaactgggacataggatc
				gtcccgctatgatggaagtgttcagacagtttataatagtaagcccctgtgaccctctcacttaccccgagacctcactttattacaagatctttccaaataccca
				aatgtccctgcaagcccgttaaata
591	4011203	OPHN1	NO	tcccaggctcctatgcaagttttttttccccattatatcacacttatctagcaagggaccttgtggtttgtggctttagtggccatcatttctgggggttggcttttac
				ccttttttcttgaatatttgccaccaagtgaaaaatgttaggacataaacccttgccaggtccctttcatttgctatctctattattggaaaggacctaaaaattggtgt
				aatggggcagaaatctgaggaatggacatttctaattcctgtttgttgaagggaagttgctggaaagagcatcagtacttgtttctatgcagatgcctgggccg
				tagcttgtctgtagcgtctgtataattataatgttgcccagtgtgagggaaagagctttcctacttgcactcttctaccaaggccctgttagtgcactgattatagta
				ctgacagataaacctagataaagagatagagagtgagtacatgcacactcatgtgcaaacccactcagagatgcatttggaacagtgctactgaaaggcag
				tagtcattttcaagactgaattccaaacatggtttattggtgagttaggaacatgtaaggccaagtacactgagagcctttttgaaagtaattgagtggaaacttg
				atgccattctaaatcaaggcatatccaggtggcccggttgaactcactccactgtacccagtctcaaaggccaggttgctaagaaaccaggagtaaaagagt
				caagtgaccatcatttcacctgctgcttgcccccaatagtagtctctgtgaggccttactgacctcacctaggaagtgatttttgagcccttgtttcagggctgtg
				gcctccctgctctatcctgaataaagcagacaggtgtgcagattttggccatgaaagcatggctaatagggccacagtccctttaaagaaacatggtttgact
				ctggttttcttgggggaaaataccacaatcaccgatgcaaacattggaagattattgagagccctagaaagctgct
592	3349796	—	NO	tgcagaaaaggtggataacccaactctggtggg
593	3040457	TWISTNB	NO	tgcctcagccattctagttttgttgtgtgttggaggacagtctaatgaagacaggataaatgtgattctgactagtgggaaatttcagattactttttaatgattgga
				atgggctataagatattgtgctgaagagaaaacagttgttctgttcactgctttcattgagaaaatgtggaatgtctcttgactaattgacaaagtgtaatgaaatg
				acaagctggttgaagctggtaatcaatgcatggccatatttattcattttccacacacttgaccatctactttgtataacacattctgctaaggcccagggataca
				atggcaaacaagatagatgtagttccttcccttgtggcatgtcataagagaaacagatgtgcatatacacacaataaataagaaaattaataattgtattaagtg
				gtatgaaaaaaagggggaggattgttcactcactgttacctgtgttagtatctgcaaatgcatgaatggttgaactcccatgtcagcatttttgttgccatttattta
				gtaccagacatagtgctggtctcacagcttaatatttggtaatgaataaattctgctagtggtatatgttgatctgaacttacaatgatgggatatagaattggcag
				agtggcagatgttcacaattgtctacaagtagatgtgctagacaatggaaggatgcaggccaacctctttgattacaattgagattcatgtgactattgagccct
				ggaaatgtagcttgtcca
594	3895503	—	NO	gtggcggaccgtagaagagcaagccca
595	3907654	NCOA5	NO	ccaggcccagctagccaagtttggaatggcatttgtcatgtcagtagccaccacctttgttcattgtgaacctaccaaggctttccagcttcatacacattgacc
				agagctcaagctcctgcctgcaactcctgcctagagttgaagaaaagcaaactggccttggcaggcacagtgtcatcataccctcaccccatatgtttgggg
				tctgcttgaggattcataaatcagccactctggattgttgaggaatggccatggcagccacagaaaaaagaatttttctctctgagccaaggttgttttttgtttttt
				tctcttttcttttttgttttcatttcattggaagatctccaatggactgaacagctccagtcagcagcagttaccacaaactgtgaatctgggccccaccactcttcc
				ctgttaaccagttctgtcagcatccccctctccagcagcacttccatgaagttggttctgagactctggccgtgaacacccgtttcttcagtgatttgttttgggct
				tttggctcaaaaccccaggctcttgtttttgtctagactcttattctgtttcctgagcagcaggaggtagggaccactttgatgtcagacttctggtagctggacat
				gttctcgagatgggtggctgttcgcgacttttgtaccagagtgaaattgttagaaggagggtttctggctgtggttctaaatggagccccaggaagctgccctc
				tccccagggtttgtgctcagtagagcc
596	3679982	—	NO	aagagacacttttccctaagcaggaagttaataattaagttaaccaagaaatagaagtgcatgagtattgtttggaaatatggagaagggaagaagagtaga
				aacagctgaaaagattaaaagtgattgctttggcgaggt
597	2858366	—	NO	agctacacaggaaataacaccaccaaaaataacacattcaaactcagagggcaatcttccctaa
598	3048215	MRPS24	YES	accatgccgcagagcgaacggtggaggatgttttccttcgcaagttcatgtggggtaccttcccaggctgcctggctgaccagctggttttaaagcgccggg
				gtaaccagttggagatctgtgccgtggtcctgaggcagttgtctccacac
599	3168775	—	NO	atctgtagccgtagtaaattttggaagggcaaatcaatatggcgggtagaggctagttggtgaagcttattaacacagattcttttccaggctaaagttgtcttca
				gtggttaacctttgtttctcctagtagagaggtgggcaggataccttttgtctttgcaaatctatgtcttgatttaggcaagtggaaggcagagaggtttcttgcat
				ctgctccttcaaaactaccttcagta
600	3643388	—	NO	ggaggtattactgagcgccacctggctg
601	2927513	TNFAIP3	YES	gtgacggcaattgcctcatgcatgccacttctcagtacatgtggggcgttcaggacacagacttggtactgaggaaggcgctgttcagcacgctcaaggaa
				acagacacacgcaactttaaattccgctggcaactggagtctctcaaatctc
602	3911005	—	NO	atgcctgagggcatcgaccagaacgaaccagacacgagtccctgccctctggaagctcacgttccagcagaggagagg
603	3942797	INPP5J	YES	ttcatcctgggctactatagtcacaaccacagcatcctcatcggcatcactgaaccctt
604	2802457	—	NO	ggcctatggtaggattgtaggcataagtgctggatcaggagtcatccctcttctacctctgctgccttctgatgtttcttttgccaaccagcacgccggaccagc
				ccttcttgttttctcttttggttctaggtcacaactctttctc
605	2874851	RAPGEF6	YES	caacacctgagcgtctcataatgcatttaatagaagaacattccatcgtggatccaacttatatagaagattttctattaacttacag
606	3147604	AZIN1	YES	gaaattggctttacgatgaacatgttagacattggtggaggattcacgggaactgaatttca
607	3822303	CCDC130	YES	tgccatataacatctggtgcgatggctgcaagaaccacatcggcatgg
608	2767313	—	NO	ctgtctttggattgatggctcagagaagatggcagcatagatctttaaagcagtttgagtggggaattcttggatcttggggtacttggccatgtggacaggatt
				ggctggagaaggagggtcaggtggcggtcctgctgccaaggtctgagggtaatactgctcctaag
609	3159245	—	NO	tgtgtgtctcaaacttcaagaagtctctaggataacccaaaggcaacaagggagaccaaaacaaggacgctggagacattttagcctctgatactgacagct
				gcagcaaacagaaaacgcagcctaaccgcgggccagataaaaacctcaca
610	3403122	PTPN6	YES	gaagcagcggtcagcagacaaggaga
611	3849599	—	NO	tgggcacccgttatcctagttactcgggcggctgaggcaggacaattgcttacccagaggccg
612	3534950	KLHDC2	YES	tgcctatgatcaccttgcatggacagcaatcctgtaaacatcacagagtggcatcatttgtataattatatgcattgttgtagtttgcacctgttggttttaatgtgca
				tgtgaatggcctagagaacc
613	3631427	—	NO	ccctgttttgatatcctggttgtgaaatgtcttatgttttctgctaatctatttgtgttaaagtaagcagggttggtttacagtaccgtggctcaaaagctagtgtagg
				cagctttcctctcctg
614	3779594	—	NO	acgccaagagtccagtgcaacgatccctgccacacggtcagccgaccccacttggtgccacagggtccagcctcggccactctgggctcaacctttccag
				cacgtctgggagcccaatgaggctatgggacagtgtgcatttccctcaaggcctccggaaagtcacctgccacccactgtgacctctgaggctgaaagga
				ctaaggactcctttccccatcatttcagctgggccagtggctggctaaaatcagcgcagcattcccattcttctgaaagccacagctgaaataatgcaccagct
				gaaaccacagtggacagactgagatggcctccctctgggcctctagttggcaactttctcacccgggggctcctctttctccttttcccgctccttgttccagtc
				cttaaggccttctggaagtgaggtgtcctcatccaagctgccagtgccttccacaaattcttcataggtagatttttccgcaaatggtctggggcccaaaa
615	3931281	—	NO	cccgaggagcttgtgatgtcaccagtgtgccctgcgggatctggggaacaggagaagtaggccagagaagtcgggttgaaaggtgtgtcgtttgcgtcct
				ggatctcccttaatttaaccccataacattccattttacagataaggagactgatgctcactaagacactaatatgcccactcacacagcaagtcccaagtctct
				ccccaaaatgatttgagaattttgaggcacacaaaagggagaaaattgagtgcccgtgatccaacgactgcaactgtaggaaaccaggaaagtggagga
				gtggtagtacttctgaacccta
616	3110077	—	NO	tgggaagaggattcggactcgtcacactgcagagcagcagagcgagaaaggatgagaagaggcagagaaggcgacggcagaagaaaaaaggaaaa
				actgcggccgcgatcagagcctga
617	3419463	—	NO	gcgccctcgccctgggaaactcactggagtggggacagatctcaggcgtttggcagtcac
618	3903370	—	NO	attgtatttctattggacgctgctgctctaggttactgagttt
619	3609638	—	NO	agaatcaggaaaattggtgcagggattggcacactgcagggagaatgcatgggctccatg
620	3227685	—	NO	tcttgggtactcaccttcagccctagagcattctttagcactcacagtttctcttctcgtcgggttattctttatattaatcttttcctgtccaaattactctctatgtctcc
				tgatcagtccttgactggaagcatcaag
621	3349840	—	NO	cataacctctagagtagaaagtttcagaaggaagagattccccaaactgtgtaattcccttgtaaatctcattcattcaatgggatttgagaaccaaccacttgtg
				caggtgcccgcatccgaagataacttgcccccaggagacagcagataagaagagggcagagacaaaggaggtctttttgcgacttgcatc
622	3035683	FTSJ2	NO	cccatgtgtgccttgacgggacttcatcttatagactgttaaactgtcacacacaaacaggctttccacccctgctctgagagcaccacgcacagatttccagt
				tcttagtgtggctgtttaaagtagaaaatctgggggctgggtgaggccactcatgcctgtaaacccagggctttagaaggctgaggctgggggattgcttga
				agtcaggagttcaagaccaacctgggcaacatagcaacaccccccatgtctacaaaaatgaaaaaccaaaaagcaaaccaaaagaaaaatctgaaatttc
				catctggggattaacttctgtctttctggtgaacaatatagcaattcacgcattcttcaagcagcaaaagttcccggaacaattagggaagacgtatggtctgaa
				tttatccaggcagtgggtctgctttggtttttgctggaaatttatatcagtgtctgggctcccaagaacataaatgtaattgccaaagcaagcagtgatgtggtgt
				gtttattttcttttactcatctaggaacttgacgcagcttta
623	3439354	ZNF84	NO	tcaagaaagagtcccgattgtgttccagtacctggttcttctggtct
624	2812078	—	NO	ggcagtgctgtagggagcttcattaattatgatagtctcgctgtgtcaaatggattacaaatggaaccacctgtggggagcctgcaaggttacggacagagg
				cta
625	3038635	—	NO	gatatgaaaaagcacgcatgcaactaactactgttgatctgctttgcta
626	3088092	—	NO	acaagagggcgggtacaaacgcacagcttccagggctgaaataca
627	3337338	ALDH3B1	YES	atgaaggacgagcgtgtgcccaagaacc
628	3420557	—	NO	gtaagttgcctgtcgctcctctgaatttt
629	3841267	CNOT3	YES	atggcggacaagcgcaaactccaag
630	2929962	STXBP5	YES	tcaaggagccttgcacagcatattcctggccctggtggcattgaaggcgtaaaaggggcagcatctggagttgttggtgaattagcacgagccaggctggc
				actagatgaaagagggcagaaacttggcgatctggaagaaagaactgcggccatgttatcaagtgcagagtc
631	2387074	MTR	YES	gttgaggattatgcattgaggaagaacatatctgtggctgaggttgagaaatggcttggacccatt
632	3388958	—	NO	gtaggtgccgaacaccgcgagtctccgcgcccgacccgacctcgtgttcgagtgtgtgcacgctggcgtttatggagagactagaagagccgcccacgtt
				aagagtctacgtgccctgcagg
633	3620562	—	NO	cccaaactgaaacatcatacctatta
634	3870278	—	NO	gtttgacttctgactaaaggtcttg
635	2833045	RNF14	YES	tacctgcaagcggatgaggctaataaaag
636	3030300	CUL1	NO	gattgctgcactggacgactttagaacatccctcaca
637	3767510	—	NO	agatcgaggacagtgttgagacaccaccacctc
638	3039444	—	NO	gttcaaacagtagtttactcctgcctcag
639	3067653	—	NO	agtatgggagaggggtaatgctgagca
640	3139926	TRAM1	YES	aattaacaggcgaatgcacttctccaaaacaaaacacagcaagtttaatgaatctggtcagcttagtgcgttctacctttttgcc
641	3203423	B4GALT1	YES	atgtctatatctcgcccaaatgctgtggtcgggaggtgtcgcatgatccgccactcaagaga
642	3875984	—	NO	tctttctctgggttcatttcctaactgtctaactttggg
643	2848542	—	NO	atggtgtggcaagttgactgtatcgtgatgttagccgtcttgtggcagaga
644	3134299	—	NO	agaccacagaaactgggcgggcagcagatgcagacacagccatcctatgcatttag
645	3538031	—	NO	tgaccacgtgcgcaaattatttttcttttttagtagaatggtgcattttttgcctttgtatttgaaatttagctaaattacaatagctatcagaactacaattgaccttagt
				aatttcaaaaccatagttataagggttttaagttgatttttaaaaatcttaagatatgatagggatttcaaaactatgtgtgtgtatctctgatagggaggggttggg
				gcacagactaataagtgtgccaaaaatctgtgaatccaaatgtgtaacaagtgttgtctgaataaatgtccacaaatccatgctattattg
646	4037525	—	NO	tgtattagaatgtaatgaactttaatggaatgtactcgaatggattcgactggaatggaatgttctggaagtgaatggactccaatggaatggattcaaaagga
				atggaatcgtacgga
647	2814589	BDP1	YES	agcttctgacatctctggaggtttcagcaagaaaagattgtgtaggttccaaagagtctgctttggcaaaaatagatgcggaattagaagaagttggaccatc
				aagaagggttggagaggaaactgtaggagataattcaccatcttc
648	2823139	—	NO	tcccaacctggcagtgctgagtggg
649	3113389	COL14A1	YES	ggacagaaccagctacaaccatagtgcctaccac
650	2853728	C5orf42	YES	cagcagtgagagtcgtccagtccatggctcgtttcatggctgcctatttcaccaatcagcagctttgcattttgccccctca
651	3895815	RNF24	YES	gctcggatttcccacattacaacttcaggatgcctaatattggattccagaatctgcctctcaacatatatattgtggtttttggtactgctatatttgtcttcatcctta
				gtttactcttctgttgctac
652	4013748	BRWD3	YES	ttgttgatttagattcagacggtcctggtacttcat
653	3384440	—	NO	ttgtccttgggcaaacgtggtatactttctcagtggtggttggaaggaaatttgttgccctgtcatttcgcaagtatggaaaaagacctaaaggagaatttagca
				gctgcagccgctgtttttattgcgtactttactagcgccaactctttaataatcgcttgttagttgttacccctgttttatgggtcaagagactcaatatatcagtactt
				tggtaaggccaggcagc
654	4026568	FAM58A	NO	aggccgggagtgtactgtgtgcagctgacccaaggcagccacatctgcgtttgtcctttgagaggactttgactacaatacaggcatgacatcaatgaaagg
				aaagtcatgaaatcgatgagactgaatccctacggatttcttaaaagccagatttgtagggagaatgaatgtgca
655	2675946	WDR51A	NO	gccagggatttgtaccatgggacttgg
656	2941689	—	NO	tctccaactgcagcgacctgtggctcttcagat
657	2330052	EIF2C4	YES	gaaggcagtcatgtgtcaggacagagcaacggccgggatcctcaggccttggctaaggctgtgcaaatccaccatgatacccagcacacgatgtattttg
658	2726487	OCIAD1	NO	cgcagtgaggtctgacgtcatttcc
659	2902605	LY6G6D	YES	ccccagtgaccttgattcaccaacatccagcctgcgtcgcag
660	2732332	—	NO	tcaaaagatttggagtctagagggcagaaattgaagaggttggtgctctgcacgtctgagtccgcccacagactgaataaat
661	2329455	—	NO	ttcctggatcacaaagggctgtaggggttccagagatgctggagctctggtacaacaggagggccacaggc
662	2373856	PTPRC	YES	gtatttgtggcttaaactcttggcatt
663	2465069	SMYD3	YES	aaaaagcttggccagaccacaagcgggaatgcaaatgccttaaaagctgcaaacccagatatcctccagactccgttcgacttcttggca
664	3046899	VPS41	YES	tgatggcagctgaaattagccaaaa
665	3418387	GEFT	YES	ttgccgctttgcactgacctccagagggccagagggtgggatccagcgctatgtcctgcaggctgcagaccctgctatcagtcaggcctggatcaagcatg
				tggctcagatcttggagagccaacgggacttcc
666	3568670	—	NO	ttcttgcagtagtgcgtgagctctcactcttgctctggggagtctggattagtccttgagggaatggattagttcctgcaagggtaggctgttataaagccagga
				tgctctcaggctctcctctgtttgcatgggttggcttcc
667	2824307	—	NO	aggcacaggctcaattagtttttcaaactctagccaaggcagtatttcatttgggaaatcatgcaacagaactgctcaattcttaacttctcctgctgttaacattta
				cacttagactgccagcaacagttaacttaaattttggtctcaagggaacaaaaaaaaattgcattcagaatttaatatagtattttaaaactaattttagcctgtaag
				tcattatgagcaatagtaacttttgtacctcctcatcttgtctgataatatattctatatgctgtcaatctgattatatagtctatatgctagaagttgctgattttcattct
				gccaccaagaaaactgtacttttatttatgggaaaaggatttaaatactcctagatacttaaaatttttttaatctaaaagttgattttctcccaagaacaattttgtttg
				ctttctacaaagttttaagtttaataaaatgccggtaatcaccactgttttcctccccaaaataaatgctctgatccatattatattagagtgatactgtcacttagtat
				tgatatctttaatattttttacatcatgagacattgttatgatcttacctgattgttatctcaaggtgagctaatcatctttatttgccttaaaaaatactgtactggctgg
				atatttaatcttgttagtttagttatacacttgttttagtcgagtttaattcaaaaggactcttaacagtatggtgtaaaactcagattttctagtccagacaaattgctc
				tctataacgatttggcagatcaatggagacatccgttttaactttactgttctgtacttactatgtagtcatgtgcagcttatcaacacaaagaatacggatgaggg
				catttaaatggactacaagtgactctgacttgtaaactagggaagcctcttgtgtttgaccttaaaggccagagaaaaactgaagatagattgacttaactattg
				ccaagcagattatgggttactttatacttcctttcattc
668	3204568	—	NO	agccctcaggccctaccaaccttgactgtcctgtccc
669	3410647	—	NO	cccaggagtactagttgagggccaggctgctgagaagcagttgaagtagccttgaagcaaggatgggagattgctgggtgagatcaaagatacgctggg
				atgggggtgagtgaaagtgtgagcaatgagtagaggcaagattgtagatgctgcatttggaggaatatttctgactgcataatcagaggtcagaatggctag
				agaaattaatacagaggtacaaggctagatttagaagagtaagctaagaacagactgcaatgggcttttgaatg
670	2555029	—	NO	catccacgtacacatatgagctgtacacatagatgttaatcaggttgcttttttcattttatttaaatattcaaaatattgtgtgattgtgatccattgagatcattgaag
				tagtattaatttagctgggaattagcagcttatgttgtgtgggcccagttcatcaatatgtgtgtcaaatatccaccctcagatatcagcagcctttgacttgcagt
				caga
671	3238290	MLLT10	YES	tagtaccttaattggcctcccttca
672	3490689	—	NO	tatagaggaaacctatcagggcagggacagt
673	3571835	—	YES	catccatggattgggcccactactcatagcagctcctgaggcaggtaaatggggcaaggactcacgccaaataccacacgcgtatgtcaaacacccaagg
				tcggattctggggcccctgccctcaggaggctgtcagactgttccccctaaacacacttctgaaggttgtagggaccttgccctgctgtct
674	2318698	PER3	YES	ggggcacccgttcattacttcgagaagcagctcacccttgcagttaaacttacttcaggaagagatgcccagaccctctgaatctccagatcagatgagaag
				gaacacgtgcccacaaactgagta
675	2330382	—	NO	tggcccagctacatttgcaatgatgtgcacgtaaacactgttaagaggttaaagcttgtatacaatctgttactgtgaaataactaaattgggctttaaaaaaatct
				tagtatttattgatcttcattcacatatacagttgaaatttaaaataacagatggttattccaatgctgctgaaaccttttctaaaaaatacttgttttgttggttgaatgt
				gatgagaggcgcttctgggcagtctctcttctctcccacccgtctttcctcctccgagtaccccttctccagctttgtactagccatgtaaaacccaaggttttctt
				taaaacatcagaagagatctcgtcctccatgccccaaaaaagccaactcattggaggtgttaccc
676	3837059	GRLF1	NO	ttgggtgttgaagtggaatcgtttcatcccagcc
677	2582942	—	NO	tcaatcaggtcaaccacaggtcatatgaaaccatcttcccaactcccccacctccactggttctgaagagtgggtgtaaacaatgggttaaacaatccaggat
				gcagacagctgttaatcataactggctccaca
678	2876012	—	NO	tgtctcatctaccaattcctgctattataagatcaacttctgcaaaaaccttatccacctcaagtatccttagcagc
679	3372066	NUP160	YES	ctttgccttaacttccacggatatctgggccctgtggcatgatgctgagaaccaaacagtagtgaaatacatcaactttga
680	3781765	C18orf8	YES	gagatgcctcataaatttgtgatagccgtgctgatggaatacattcgttctcttaaccagtttcagattgcagtacag
681	3278980	DCLRE1C	YES	ctggatcacaggtgcataccgccatgcc
682	3435777	C12orf65	NO	gttcaagtgcaatgacacacgcctataatcccagcaccttgggaggctaagacaggaagatcacctgagcccaggagctcaagattgcagtgagctatga
				acaccactgcactccacctgtccacttgttcttgtgtgacagaacaagaccctgtctctaaaaaataagataaaaccataaagaaacacagtcagtactataca
				agaataatggctacttctagagggaaggagttgtcattgtgatgaggcacttggaggggttctggggtgcctgacaaagttctgtttcttcacctgggtggtag
				ttagaagggtgtccccgtatttcaaattgtacctttgtgagattgtatg
683	3524572	EFNB2	NO	gctaggctgtctgcgaagaaggctaggagttcatagaagggagtggggc
684	3790001	—	NO	cagaacaagtgcatctgctggcagccagcttaaggagttagcagccctcaattccaataacgaacgtgtaaatcagaattc
685	3301881	TM9SF3	YES	gaaggagatggataaagcagatgtttattggggcattccttatcccagctatggtgtgtggcactgccttcttcatcaatttcatagccatttattaccatgcttca
				agagccat
686	2745373	LOC100130178	NO	tggcagattatgtggaccatcaacaaactaccaaaa
687	2774241	—	NO	tgcacagacaattccctttactaggtgtcaccatagctaccatcttcatctccttcaaatgttgctttggcattgaggcttaccctcacttccttatttaaaattacaa
				ccagctgggcgtggtggttcacatctgtaatcccagcaattttggaggccaaggtgggcagatcccttgagctcaggagttagagaccagcctgggcaaca
				tggcaaaaccccatctctataaaaaatacagaaaaaacttagctgggtaatggtggcacacacctgtagtcccagctattcgggaggctgagacgggagaa
				tcgcttgagcccaggagatccaagctgcggtgagtc
688	2852754	AMACR	YES	tacgacttacaggacagcagatggggaattcatggctgttggagcaatagaaccccagttctacgagctgctgatcaa
689	2390973	—	NO	tttgccagtagcctcataatgagcgtgaggtagtatctcattgtagtgttaatttgcatttacctaacaattcgtgatgtggagcatcttttcatgggcttgttggctg
				ctgtgtctcttctttggagaagtgtctgttgaagttgtttgacattttttaatcaagttgttggacaggttcccttgtttttaagtcagagtaggtgatgtttgtcttgaa
				ggttata
690	3457600	ANKRD52	YES	accaagagaggcgaactccattgcatgctgctgcctacgtaggcgatgtccc
691	2853708	C5orf42	YES	ccttattccagggatgctgacattccatttctaactagtttttctggaaagcttagagaacatgaacttaattctttactttttgatgtacatacaacattaaaacgac
				atcagagcaaaactaaaagccagaatgtgtttagagctggttcttgctttgttgttgctcctgagtcctatgaatcagaaaaatcatcctctttaaatgatgaatat
				ggcatgcatttagaaaaccagaaactttcatcatcagtactggttaatcaagggatca
692	3055843	—	NO	cccagatggagacacccatagcagggcgccggatccaatctcttcctctcctccctcggccttcctctccccacaaaccccagggtctagaaagtagaagg
				ttctcccctcttctctccttcctcataatgaactcgatgg
693	3139045	ARFGEF1	NO	catggtttgcggaggttagatttactggaaatgtattcatactgtgaattgtgctctgatggttaaaagacaagattgtcaagcattccgtattaacagtggatgta
				gaaaattttttcagatggacaaaatgtatatggtacagatgtaaagttttctatgtaaaaaattctgtacaactttctgtacaatattgattcccatctggca
694	3607791	WDR93	YES	ctgcctatttgcaatgccaccggaagtcaagggccc
695	2666907	SLC4A7	YES	accaagaaagaaatacgtggatgctga
696	3887309	—	NO	ccagcagggggttcccatccttcct
697	2333654	DPH2	YES	tggaagacgagggattgccatcgcctatgaggatgagg
698	3333566	LOC751071	NO	gtctgcggacgctgtataccctcctccac
699	3278417	FRMD4A	YES	aagccagagaagctcgacaccgtcaagtgaaattggagccaccc
700	3986088	NRK	NO	tcgacacggagcacccttctagcttcttcgtctccaggactgacgctcaggctcctctctcgccttagcccaacttgctttcccgcctcgcaaactccgg
701	2558398	LOC100128333	NO	tgcccaccagccaactagacagatgtggcctgcattgtccccctggaggcaaaggatgtgtgggtatttatttatttaagatagtaagttatggccaggtgtgg
				tggctcacgcctgtaatcccagcactttgggaggccgaggcgggtggatcacctgaagccaggagtttgagaccagcctggccaacatggtaaaccctgc
				ctccactaaaaaatacaaaaattagctgggcatggtggtgcatgcctgtaatcccagctactcgggaggctgaggcaggagaatcgcttgaacccaggag
				gcggaggttgcagtgagccaagatcgtgccactgcactccagcctgggcaacagagcaagactccatctctaaaataaataaataaataaataaataaata
				aataagacaataaattatataagcagtgctgaatacagcttcatcatttaaaaatccaaacagtttggaaatatatagacaagtatataaatgctcttcttgcaccc
				cttcccccatcctaaagcctaccatacaggtaggcactgttaattatttggtggaaatgtttacactttttgctttgcatttacacatgtgagtggcagggatagtat
				ctgagaaattaatttttttctctcctgaattttctctttttctgccctcacatttatggagctcattacctccagagcagcttttcaggttagaaaactgaatttatcttca
				ggcatctctggcttttgtgtgctgaaagcttaagcatttagggcaactccaggatttgctgagtggctcatcaaaggatgaggattctcttgcacagactgaa
702	2830633	—	NO	gcattgtgtatgctgaagccatcatcactctcgctcacaggaggttcattatccatttctgacaagtagccttctccttgatcctcttccttaggc
703	2546259	—	NO	tatacccacatcactaagctgggaggcacattt
704	3615631	TJP1	YES	ttccgtgttgtggataccttgtacaatggaaaactgggctcttggcttgctattcgaattggtaaaaatcataaggaggtagaacgaggcatc
705	3729022	GDPD1	YES	gagctcccaccttaccttggcaaactggatgtctcatttcaaa
706	3729073	YPEL2	NO	tgatggcctcttgtcaggagagcagtggcacgggggcgtgaggaagagggaaaggggaaactctaagggtcctggcgcggggaaggggtggaaggg
				tggaggtaggaacaaaattgcgccgctcctggagacctgataacttaggcttgaaataattgacttgtctaaaagga
707	3043777	—	NO	tgcactacatcgctggcaagaattgttcagaaaggctggcctgctaacgacttctggggagattttc
708	3080463	—	NO	aaggcacctacacaacatcaggccacttgg
709	2969705	REV3L	NO	ttgctaataaatgtaggccggaggggatggcttagtggtctaagcatcagatttgaaatacctagagtccctggaactgcaggtttgaatgtcagcagagtca
				acccagc
710	2904894	MAPK14	YES	attctggattttggactggctcggcacacagatgatgaaatgacaggctacgtggccactaggtggtacagggctcc
711	3421016	—	NO	atgcctccagtatcggatatgtgggcaggcacaa
712	3724753	NPEPPS	YES	tgggttttatcggacccagtacagctctgccatgctggaaagtttattaccaggcattcgtgacctttctctgccccctgtggatcgacttggattacagaatg
713	2600045	GLB1L	YES	tgttgtggagcgaaatatgagagacaaactatttttgacggggaaactggggtccaaactggatatcttggtggagaacatggggaggctcagctttgggtc
				taaca
714	2893581	—	NO	tgcatttcagcttggagtgcgcagcatgaggcatttgtggttcagaaaagaggtcttcctttttcctcctcctgttttcttttccttccttctccccaactccccaaag
				gcttactgcctttcttctcaggccacgtgtgtagataacctttgaggaaaagatggtttccgtgctgggatatttggatattacctaaagggacaagatgagccc
				tttctttgccttgttttctttctctggcctcatcagagtgaattatatctgactgtgtgacagttaattgtaccatccatcccgtgtcctaagctgataagccc
715	3712473	MPRIP	NO	gtgtgtcccatccaagttgagcacgcgccttccccagcttgcagcagcacaccccaagcgctgcttttcacctgtacctttgttttattattattattattattgctgt
				tgttgtcatcgttaactgtgggcatggaa
716	3026735	—	NO	ccatgatgtgaaaggtcgggtgatatctgagagctgaaggaggttaagcggatccatgccaggctgacaaggggaacaggtgcctctgccctggactgg
				agcctacgcaaccatcttctgctttatctagctgctgtctgtctcctgtctctgcgtgagtgtgtg
717	3603221	IDH3A	YES	agtcgtgcagagtatcaagctcatcaccgagggggcgagcaagcgcattgctgagtttgcctttgagtatgcccggaacaaccaccggagcaacgtcacg
				gcggtgcacaaagccaa
718	3820895	CARM1	YES	ccaggtggaccagaccggctccaagtccagtaacctcctggatctgaa
719	3183801	RAD23B	YES	agaatgagaatttggctgccaattt
720	3420741	CAND1	YES	agaaaaaagtgtgaagacccgacagtgttgttttaa
721	2356132	TXNIP	YES	cctgctatatggatgtcattcctgaagatcaccgattggagagcccaaccactcctctgctagatgacatggatggctctcaagacagccctatctttatgtatg
				cccctgagttcaagttcatgccaccaccgacttatactg
722	2625835	SLMAP	YES	ctttcaaagagtggcggggactgcacttttattcatcaat
723	2996070	AVL9	YES	gtctgtcacctcgagatcttgtccttcatttt
724	3175548	—	NO	cctcaatgggaaccctggtgcagaa
725	3810034	—	NO	tagctgttcaggaaagctgtgtggctggagcagagaatatactggaaatcagagaggtcaaaaacaatgagcaggagatatcggaagaaatgttcctaacc
				acttcactcttc
726	2767097	—	NO	agtatttcatgacaactctaagaaggacagcactcaggggcagaatccgcaaatatcacctatttccaattatacttcacatgtgcatatgtgcacacacgacg
				gctgtc
727	2853747	—	YES	ttattctggggaatgcctgaagttaacatttctagcaattcggtggcatgagaatg
728	3016374	—	NO	cgcagtttgtcagcatcgatgtgggactgggagaggaaggatattgccagttatggttga
729	3845911	LMNB2	NO	tttatggcctgggaaacaatttgcatttgtccccaaatacgcttagctgtgtgccgcttagaacgatgcgaaaccatccctctgtgtaagcccgtg
730	2642763	—	NO	gtggcaggagtattttcaccaaagaaattaaatgctacaaatcctaccaccacaccactggtttgggctcatagaaagtttgttaagagtctgtgacatgaggt
				ggcctctaatacagtgagttcaatatttgaacttctgtaaagaaaaggattagatttattcagtatgatcttaaagagggatgctaggggcagcaggtaaaaattt
				cagggagacagattttcgttcagtgttgggaaactcctgaggtaagaagtgcccattaggctgggtggccactcaccttagaagagagatactacagagaa
				ggctgaaacatggaagattgtaggggttgagtggctcattagtttggccaccaaatc
731	3642784	PDIA2	NO	tgtcacccccgccatcactgctggacaggagccacccccttgggtaccagagggagctgtgcattgtgaataaaga
732	3178621	SECISBP2	YES	tgttaccgaggttttcaaacagtga
733	3681988	KIAA0430	YES	cgatcggtgcagtgaatagcctccacagatacaaaattggcagcaaaaagatcctggtctcacttgccaccggggctgccagcaaatcactctct
734	2973750	—	NO	ggagcgtgggagttcatattttacactatgttggtacttaccatgcaaatgaacggccctgctgggaaaagaacctttatccagagaggggatccgaggaaa
				tagtaagagttgggttccgagaagctgtgctgcatcacgggagagctcggtgtta
735	3284084	EPC1	NO	atggtgcggaacctgctgttttatctatttattgtgccgtgtttacagttttttgtacactgtaccttcattggttcctgtgctgtagtaaatgtgttaggtagctgtgga
				ctccttggtattttgtaaatggtataacataacttggttcccctctgggtccttgagttttctgtgtatcatgtgaaaaaaaatggtgacatacatacagaattttaca
				aaaaaaaaaaaaaaaaaaaaggcatcagtttttttaaaaatggggaatgtactattaaatggggatcttcctggtctactatcattaggacaagtaacaagctaa
				aaatgaagtctcttgaatctttccatccccaacttgcccacaaagctgtgggtggtttctggtacttaaagcactaatattatgttgctgctctgcgaacagccca
				gtagtcccattt
736	3642301	—	NO	ccacaggagacacgaggccgaggtggcgcagcacccaccctacacagcagtggccatgtgccaattacacgtgctgggaggag
737	3133236	PLAT	YES	tgtgtctgaacgatggccgcatgactttggtgggcatcatcagctggggcctgggctgtggacagaaggatgtcccgggtgtgtacaccaaggttaccaac
				tacctagactggattcgtgacaacatg
738	2858415	—	NO	gctggtaataatcgcgtttttggtaaaaacacctcatggaatttttttcctttctcataaaatagctgatactgtaaaattgagatagcctctcaagtctggaacacc
				tttcaattcatcaaaaagggacaacctaatattccaaagaagactcaatccttttaacacacatacattttagggccagtcaagagaagtggcctgttctgtagg
				aaaacatttcttggcacattattattttaagtgattgcaggagaccacagagggagagaaaagagacaacaacaacttctagcatgcctgggggatgacttgc
				tctttcatatttgtggaaccctatgtcaagagagaaaacatctaaaaataaaaacgcatttactcagattctctagggcaaggtgcaa
739	3301253	—	NO	cttgtggcattgtgctaaagcaaaaaggaatggaatttgcaatgagagagcctttcaagttcaggctcagcctttagctgtgtgaacttgaaccactcacaattt
				ttctgaatctcaatttcctcatctgtaaagtttatctaatatgttggtggtgaggtaatcatattattatctcaaataggagattgtatatgaaagggctttggaaagg
				caaatcccattatttgtttaaatcaattttttcccctaaaaaagatagctcataaaagaatgtgaacttaatctgtatgtgtaatttctttcaagtcctatctgatgttgct
				tgtgac
740	3068212	DOCK4	YES	aatgcctgtagtgtccagtaccgacgaccctttggctgtgcagttcttagcatcgctgacctgctaacaggagagacaa
741	3664307	—	NO	ccagcaattctgaggcagggaccaatcaga
742	2357616	LOC388692	NO	atgtggattgtctaactggaggttgggagtccagggtgcagaaggagaagcttggagtgcaggatttggtggtatgtgtgtggcagtaggcactatgttctaa
				ttgccag
743	2824047	—	NO	atgaccagagtcataggtggtgatgt
744	3348756	C11orf1	YES	atttaagcgagagcctcactggttcccaggacatcaacctgaactggatcctccccgata
745	3561991	—	NO	cttatttgatgggtggccaagatactgggtagggtggtgtgatttgctatactgagtagatcagtaaacaataaagtataaatcttgctttgtagttggaaggtca
				gttaacaaatatttagtcaatatgatgctggagttggctaatgtatcccccaggtctaattaatgaaaataatcttgcattggtctttaggaaaatcatttttattctctt
				tctgaatacttaaccatagttgtttacatgttttactgtggaagtaatatcttttatgaatgttttagagaaaacaattatggttcacttggaccattcagtaatttgtcc
				agcctggctagtttctagttatctga
746	3051857	—	NO	agagaagaatcctccgacggcttcgttaccatcctgtctgaagcggattgcacgagccc
747	3459696	—	NO	tgagcttcacatggggtcaaactggaaagtatctctttgctatgctcccatttaattaaattaggaaatctgcctaaaacttgaatcactcctcttttcagctggtgg
				ccaggcaggaatgctccctgaagagtactctttcaatagacttcagaatgtgttacctgaaaagtgctcatgatgaatcaagacatcactgtgttttccatacttc
				tgaagtagagattgtccactaacagcttagggaaagcagagtacccgctcagctgctctttttctggtgtggtcagaccagctgggtcctctgaaacatgaat
				ccatagtgcttcctttgttatactatttctgactcagttttctctaaacggctgtaaaatttaactgcctagctgtattttctttctgtggactttatgctctcatatttagg
				agaaagaataagagaacaccaacttacatctctgtagctctggatgattattaaggccctggtctaatgcttaaaggtaagcatctgttatctatattcaataaaa
				gaggaaaatgaaccccagagagaaatcaagttactttagaatcgcaggctgtcccatgaccctggtgaccatcactgaatta
748	2614179	—	NO	gtgaagccatcagtgtctacagcttcagctattgcccgtgtgcagatggtgcttaatctctcttgtgccttccagacctgcatt
749	3047613	—	NO	attaggtgatggtagcggactagccgacggagggcaggcaggggagggggagaggactttacagaaaaggaattctcggtcgagctctgcctggagat
				gactggcttacacttactaaacccagcgggtca
750	3677890	CREBBP	NO	atcaacagccgccatcttgtcgcggacccgaccggggcttcgagcgcgatctactcggcc
751	3177929	DAPK1	YES	tgacaattcaagatagtttgcagcatccctgg
752	3211613	TLE1	YES	tcctggtcccagacagtctaagaggcacagataaacgcagaaatggacctgaattttccaatgacatcaagaaaaggaaggtggatgataaggactccag
				ccacta
753	3452723	RAPGEF3	NO	tgtgagaaggtgaagcccataaggcacagaaggagttcagtgagaccagtgacttcaggctcagtgtgggagaccaggggaaggatgggcatgcagg
				gggcgggggactaggctgtgggggaggcaggatgcatggaaggtagggaaggctgaggaggtggagccaaagtcggaggtgggagaagggctgtg
				ggtccctgtgggaccctcatggggctcaggggctggaatgaaggaggtagatgagagggtctaaagctggaacatcatgagttgagcatgggatg
754	2845333	—	NO	ggggctaacatggacggtcaggagctacgt
755	2852760	—	NO	tgaatgcctgaatctcaaacttgtacttcatcatggactccagtcttcctttcacatccaatttcaatgatcatcaatacagtcattttgctccttagcccactcggac
				tatttctctccatacctgctgcaactgccttgacactggtgtgacagccttttaaaaactggtgtttggggctggtatcactccagtggattc
756	2750640	—	NO	caataagatagacggaaatataatatttaaggttagagaagaaggctgagtgtggtggctcactcctgtaatcccagcactttgggaggctgaggcaggaca
				atcacttgagctggggagtttgagaccactcagactcacttgagacca
757	2807722	—	NO	ttcttatgcaaacaacaccatctgggctctggaacttcacaaaaggacactgttaagtcacac
758	3338718	—	NO	tcatccatcaggctgtgtcagacgcacctgagccctc
759	3482760	—	NO	tgaccccagacctagggttgctggtgga
760	3884900	—	NO	tgcttcgattgctttcgagtcatgagttggtg
761	3038653	—	NO	aaatgtgggcccgttaaagagcaagactctagaaaggaatctagccaaagaggacagcgttggtgggatggggataa
762	3340340	RNF169	YES	agtcagagctgtagtgacacagcccaggaaagagcgaagagcagagtcagagcagttccaggcaacaaagccaag
763	3441973	—	NO	agtgctgtctacacgctgagtattaaatcctaaatgtgtatattagctgacaacctctcccttgaactctgcactcacataaccaacaatctaaacctctccctcc
				catatgctaccccatctcagtaaatggcaacttcattcttctagttgctcaagtcaaa
764	3629351	SPG21	NO	acccggtgtgttcttgtatagtcagtggcatcagcacccgtcagccggccttttccttcaggttcgtcaggctcaccg
765	2611420	—	NO	gtgctggcaccatcgagccacaactcaggggcctcatc
766	3371610	—	NO	acagttttgagacaggtggttcaggtg
767	3795789	—	NO	gcctggctcttccttaccacccggattttgtttttgctttctgggtagagctctgatgttgccaaacagcctgtgctcctcgtgaacaatctctccagactcaaaat
				agcgagcagccaaggggctgccactgcttgcggtccacag
768	3118031	—	NO	aggaaataactttacatgtgctcctct
769	2976043	IL20RA	NO	tcctgtgcaaacaagtgagtcacccctttgatcccagccataaagtacctgggatgaaagaagttttttccagtttgtcagtgtctgtgagaattacttatttctttt
				ctctattctcatagcacgtgtgtgattggttcatgcatgtaggtctcttaacaatgatggtgggcctctggagtccaggggctggccggttgttctatgcagaga
770	3330211	—	NO	attactgaaagtggcgtgcactgaca
771	2397801	—	NO	atgccagagactgtgatgttggaaa
772	2537317	TMEM18	YES	aatacatcaatgaggcggctgcgat
773	2875953	—	NO	caatagtgcaatatcacgaccaggatattaacattggtacagtcaaaatacggggcattaccatcaccacaaggatatctcatattgcccttataaagccaccc
				cacttccctcctacctcacccctcctgaactcctggtaaccacaaattatccatttgtataagttggtaattttgagaatcttacataaatggaataatacagtatgt
				aacttttgggattgactttttttcacttagcataattctctgaagattcacctaggttgttacatgtgtcaatagtttgttcctttttaaattttaacttttattttttcgagagt
				aagtcttgcactccaggc
774	2882417	—	NO	aggaaagcatgagaggtcagcagca
775	3095010	—	NO	catgcagtacattggatatgatataatttatggtttcttgtttgcagctgtttgtatctttttaatcccaaaccagacaaaattataaacattttatatacaatgttatctt
				ggaaaaagttagatgtaaataattcatcttaatctatatttgagaaatctgaggggtattaggaaactcatgagtgaatgaacatatagattggatcaaaggagg
				agagtatgagagtagggagaccaggtaaaaaggtatcatagtcatc
776	3450794	KIF21A	YES	ggatgctcctttaaacagcccaggatcaga
777	3627349	—	NO	tcttctggctcttccgtgacgcattacaacagcca
778	2360857	FDPS	NO	gggagcagctgatcaggtttctgac
779	3821204	PRKCSH	NO	gtgcggtggatactgacctttgctccggcct
780	3665595	FAM65A	YES	tggaggatgaggacgtgcagactcgagtggctgg
781	2852747	AMACR	NO	caggcccacggctcaagtgaatttgaatactgcatttacagtgtagagtaacacataacattgtatgcatggaaacatggaggaacagtattacagtgtcctac
				cactctaatcaagaaaagaattacagactctgattctacagtgatgattgaattctaaaaatggttatcattagggcttttgatttataaaactttgggtacttatact
				aaattatggtagttattctgccttccagtttgcttgatatatttgttgatattaagattcttgacttatattttgaatgggttctagtgaaaaaggaatgatatattcttga
				agacatcgatatacatttatttacactcttgattctacaatgtagaaaatgaggaaatgccacaaattgtatggtgataaaagtcacgtgaaacagagtgattggt
				tgcatccaggccttttgtcttggtgttcatgatctccctctaagcacattccaaactttagcaacagttatcacactagtaatttgcaaagaaaagtttcacctgtat
				tgaatcagaatgccttcaactgaaaaaaacatatccaaaataatgaggaaatgtgaggctcactacgtagagtccagagggacagtcagttttagggagcc
				tgtatccagtaactcggggcctgtttc
782	3004680	—	YES	tggatgagtgtaagggacaccaaggaggt
783	2722233	—	NO	tgaaattcataaaggcatgtgtgcca
784	2805960	—	NO	cccagggcattagagtgacctcacaagagtatctcagaatatttaaaaatttgaacacacaaacacaatgaaactcaacatctgtcagacatcacgtgaacta
				ctagtgaggtagttcattctttcaacataagattgcactataatccttctgataatttcatatttttgtgagactgggttttccaggccatctgataaaaaatcaagta
				ctatatggacaccaacatggagcagaaaatgagggcagcagtgtccaatctcattccaggtg
785	2952396	—	NO	aggaatggaattaataggttgtggcaatatcaa
786	2612927	—	NO	caacccaatctacagttgtgggcagtggct
787	2640231	—	NO	tgcccggcctgcaataagtatttctaaataagatcacattctcagctacaagaatttaggatttcaacatcttttgaggaggactcaatttaacccataagaatact
				atgtgggccacacatggtgcttcacatctgttatcccagtatttcgggaagttgaagcaggaggatcattgctcagggcctatggggacaccgggtgcataa
				gaccaca
788	3371122	SYT13	NO	agcaggaaatggaatatgcgggtcacactg
789	2972930	—	NO	gctgtgacacaacagtgtggcgatgtcccacagacctgaaa
790	3529011	—	NO	agcggctgcagcacgtagttggagaaggtgagggcgatgacagcctggttggtggggtagatcaccagcacagcaatcc
791	3670860	LOC100129617	NO	gagccagccaccacgttagattttagagtctcctggagcacgtgaaaacaactgaaaaagggtaaccacacatcatttcacttgtgatgtagcttgcctgtctc
				cacaccatgcccctgaagaatagtatatcacctacagccccttccccagtcaggaatggaagtgcatgacacatgtgctcctctaccccttccatgctcatgg
				cagacatcattaatcaattatagcactctttctgtagagccagagacagcatcacactctttcccctcctgcattccaggccaccactaccaactgaaatcgtgt
				tagtaccataatgaatgctatgtaccattctctaccctaagcgattgcaaactgtaaatgaattgttgctgatttctgagcccctcctagatttggggtaaattcattt
				cttgttttcagaacacaggggatagggacaccctgtgcagttctttctccaggacaaggagactccccactgggggatggggcggggtttctgccttaatttg
				ggcgctcatagtttcaaggaggagctctttctggctttggccagctagaaggaaaggtgccctgtttgttaactttaaaatcactacgggtgtagtgtatggagt
				gggctgtgccatgctggagttcagagcaaaggttcttcaggttttcttgcgaaggaccttaacttgtcaatggcagagccacacccccgggacatacttggc
				agaggaatgcctcttcaggcacataaacatttttgcatactccatgttagtcaataaaccgtttcataagggttctttgaggacatctgacttcaaagggaaaaa
				attcataattcagacaggctctcggggcttcaccatacaacgcctttcttgtatttggttagttttatgggcctggagtgttgaccatgtatta
792	3844568	SHC2	NO	ttcctccgcatgagcctctggcatggtccttcctccagctggccccgggctgggcagagcctcctcctgccggggcccctgcccaccccctcctttgcctgg
				agtgagggtgttcataccaaagacggaaccatttcgcctttaaagaaaatatatccagaagcagccgctgcctcggagccctggcccttgggtccccctctc
				gcctggctggttcggtctaacgccccggagagtcagggctcccaggaccctggggaggaggcggattccgggcctggctgggcttcctcttcccacctg
				aggactgggtgcacagttgtctttgaggggggacgcttaaggtgctttggggttctcaggccaggatacatgctggcgctgaagtgcaggcagccttgagg
				tcacctgggatctcggggtagccaggctgctccaagacagtggatatcgaggcagtcgtgaggcccctactccacctgggagcaggggaaggacgtggt
				tgcctggcctgggctgcgcccagcagcttccccccagtcctgccctcccagctgtcgacccagatgggatgttc
793	2810517	GPBP1	NO	cagcttacactgttttgcttgcagagtcatatctttttcgtacaatggaaatcctcaagtccactttgtgcggtctccctctccttcccccaaaaaacaacaacaac
				aaaacaaaaaccaaaaaggaaaatgtagcatgttggctaaaactggagcaaagtgcactaaaacaatttcctgaactcacctgttgtactattcaccttttaaa
				ccataaattgctctttagccatttgtagtgcagtaaatgttacaggaaaagacttggcacattttcttccaaattttaagaggtgattttcaaaagctttattggggta
				tgttgtcagaccagggttttcagagttgatggaaaagagtcttgtgagaaaacttattttgataaattattacacacgcagaaaaactgatcacactgactggat
				ctgtccacgacatggaaaa
794	2377968	—	NO	gtaagacacgttcccagaggcaggac
795	3020324	—	NO	tatgtaatgagcatgtgcatagtgtgtgtatgtgtttgtatgtgtttgtggggggtaatggtctc
796	3133424	—	NO	cctgagctggcaggtggcatcccaggctcgtgccaggacccagcagggctggtttccatgggcctgaaaaggcccacatcagaattccagggcatagg
				cgaggattact
797	3225212	RPL35	YES	cttcctctttccctcggagcgggcg
798	3731955	—	NO	tggaaccctcaggtgttcgcaggtgt
799	4012443	—	NO	ggagtaggggtcaactggattttgccagc
800	3145052	KIAA1429	YES	ttgatgaccccagaaggagttggccttaccactgccttacgtgttctctgtaatgttgcatgcccaccacctc
801	3542308	—	NO	gggacggtgcacatgtgcattcacatgtgttttatggatgctacagaggaatatcagaagagaggaagagggccccaaacagcccctttagctctgaaa
802	2385170	—	NO	atggcaggccccaatgtggcgtgcattgag
803	2617336	CTDSPL	NO	ggtagaactgcccatgccacaaatatttatttggaaaagtagtcattaaatgaacccactgccttaaatgtcttgaatgttgcagtcaagtgtctgtcatgtgttga
				tatccacacagaattaggccctaatgagagccttagaccctcaaccatgcccctttcgttggcatcacagggccttatttggaagagcgggcaaagaggat
				ggaaatcataaaatatttcatgggaatcgaacctagggatagtgctccacttctgacgatggagtgaagacacttggcagacttgagccagacacttcaccta
				gtagttcctgaaactgtgagcaccactgcactaagccagtgcggagctgttagggacgggcccagctcctgcaccacggacacagaatgtctggagagg
				gccagcaggccctctgagggttctggaatctgtgcaccttatttgaccacactccaaaattctgtttttattttaacccttgaatctgctttatgtacataatcaaaat
				atctatatctatatctatatctatatctatatatttttaatcatctacatgtaaatgaagcaatagaattctaacataaggccaagaaatgagacgaatgtttggggttt
				atgttttttaaggtaaatacgggtattgtttttaattattaccatgtattaaattgtgggctttgaaacctaatgaaacctgttagccacttctctgtgccatatacttcc
				catgttaccaaaatacccccaactctttagccaaaagagaaccctgacctcctgagtttccatgctcctttctgtaccaggtttaaatgtagtcttctggagaagt
				atttttgacattgagctctgggacaggacaccttgggtttgtggactgcagcccactatgatgttattacttctctggccaggcctccagtggaagtgcacagg
				cactcccaatgttgttaatgctctgtcttccatttgttctggaatcctacgtgttggtctgtggttccatgcat
804	2982034	RSPH3	YES	catggggaagacacacatcagtctccagaacccgaggatgagcctggtggtcctggagcaatgacagagtcactggaggcctctgaattcctggagcag
				agcatgtcacagacacgggagctgcttttagatggaggctacctacaaagaacaaca
805	2335196	—	NO	gtacaggaatccagctgtgtggagcag
806	3561721	—	NO	tccagctatacacccgtaacccaacagcggctcaaccctgggcgccaactaccgctgcgtcctccgccgcttttcg
807	2819696	—	NO	gataatagtagtatggatggcagtggcat
808	3408052	—	NO	catgatggttgtcttcactctcctactcccaatgattcctagaaaagaaactttaaaacatgtttctacttcccattctgcagtttagtaaaatgatttggttaactctt
				aaaactttttgtggaataatgttctgtgaattcaagtatacaaggcaggaggatcacttcaggccaggagttccataccagcttgggcaacatagcaagaccc
				cgtctctacaaaaaacaaaaagagaaaaaaaatatataatacttgaggtagttgaattgccgtgatttattgtcaccaatatttttaaatcttatatttattataataat
				acacattacatttttataactgggttataacattgattattctcacttattctagatgtgacttatttaaataagtttagaattatatattaaatacaattatattaaaaacat
				ttttgcttttatgtaaaacactatttgccatgacattttttgtcacgtaattttgtttttctttgtgtttgaatatgatcaaatacttcccaaaattaaacttacaaatgtatat
				caacatattataattcaaaagctgtttttatttgggaaataaataacaatgtgtaaagaccgggaatttgttctcctacctaagcctgatgattaaaagacagtgta
				actatgcaggtgttaaacattttctatattcttacagccatctctgttcatatatccatttttaactccacgcccctgtaagcctttgagtttgtgatccctggtgaaga
				cagtgacccacattgattttttttttttttaaggtttctctctcttttttgctttttctctcgaatataggacc
809	3628699	HERC1	YES	attcagcctcattgggtatctgccctggcttggccagaagagggtccggctacagcctggtcaggagagtctccagaattgttgttggtgggacggatggat
				ggatctctgggactgattgaagttgttgatgtgtccaccatgcaccgtcgagaattggagcattgcta
810	3350729	—	NO	tgcagacgtgcacattcccagtccgtgccccagccgtcctgggtccccttacaagcccgggtctgccacttcacccttgtttttccccatcctccgggtccac
				atttcatatgcccctgccctcattcccttatgattccctagctgctggttccagagtcttctgggcttacagtctcccggc
811	3380411	—	NO	aaagcaaggaaggtattgaagacacaaagtcacatgtgatgggctcaggagccagtgtgaggaagggctgctcatacagcacagtggaggat
812	2377588	—	NO	cccatagagctcctaaccagatgcaacagtgactgcgtcaccattccccacttttcccaactacgcagtgacaaacctaccagctttacc
813	3219836	—	NO	tgggagccgtggatgaaattgtgctc
814	2737650	BANK1	YES	catcatgaaagcaggaagacatacgggcagagtgcagatg
815	2843633	—	NO	aggctcgccttctcaatagcgtgtatttggatgagatgagtttcactgtaaagagaaaaagatgttaaaacctcattgtctaaggcccctcatctgagaagtctt
				gtctgaccctctagcccagcaggaccaaggtgtggtgcctggtcccagcctgtcctctgctcccctgggctgcagttggcccagttgcctgcctccattagat
				acggagttgctctggggctgagatgcccatctcaagtgcattctgtcggaagggttctctgctggaaggcctttggttttagttgggattccatgagctttagcc
				caaaggtggcctcccatactagcatattt
816	3478420	—	NO	ccactgtccacagaccatctggggccctggagggagcgggctgggccagggaggaacaactgggaaggggcagggaagaatcactgaacatcagtgt
				gaaggtggcctga
817	2749415	TMEM144	NO	agcttttcaagacacttcctgcatctctgacctgttgcacctctgttatcaggcacctctgttatcaagc
818	2921363	—	NO	tgacgcgggtcttacctgggctaaattcaaggtgctggcaggaatgcattcctttatggaggttttggggtagggggcaaatccatttccagtttatttagttgtt
				ggcagaattcagttctttgcagttaaaggatcaaagtctcctttccttgttgtctgttagctgagggtctttactagcttctgaaggctgccttcattccttggctcat
				gatccccttttcttcagagcctgcaatagtgggtgaagtccctctcccattttgaatcattcctgttacactatcatccctctctctgacctacccttctgtcttccatt
				tccactgttaaatgtctatttgattactctgggcccactt
819	2703246	KPNA4	YES	tagttttgaactgtgatgctctttcacac
820	3226615	WDR34	NO	gctcgcagcctttcttcggagagtgg
821	3373866	SLC43A3	YES	attactttaaggatctgtgtggaccagatgctgggccgattggcaatgccacagggca
822	2852746	AMACR	NO	ctggtagcaagttctggatcttatacccaacacacagcaa
823	3023100	—	NO	ggctcctatccctacatttcaaatagcatttctctcacaattgattatgtattaaggcttgtcaacgaaaaggaaacttttttctctcagaatttctagaacttttttcttt
				aaaaagttttttattctgtagccagaaaaatttaaagtttgtgctgggttgctttggttatagaactaatgaagcttgagtaatagtttcagacattctcagggtttttc
				ttctgcagccagattttacacttctattatctcagctgtcttataaatgtattccctccatcacacaatataattagaatgtattgatgaacagatgtaacttcatcact
				agagagacgttaaataaattatgtgttggtatcatgacttttatcaaatcatgaaggatgccatcacttttatgtgatagtccattggtatagtactaaagtttgtaag
				taaagaatgtcagatagataacaagataacttcattttcgagatctcataacctgggcc
824	3431525	ATP2A2	NO	tggtaccatccagttaagcccgtgacaaaaatggaaatttctaaatagcccaagtctccagggcaattgggaacagctttgaacccactaagatggggtctg
				ctatgccaaaacatagatacagaattcacagtttgtcctgcattaggacattctcttcaactttgccactgtagaaagtggaggtaggtcagcggatggtgcca
				cattaacagccgccttactgaagtgtagtcca
825	3695469	—	NO	tttatcctgatggaaagagtccagtagagaggaagagattgatgatgtaggagagagga
826	3761535	HOXB13	NO	ctgccaccgccactaacggagatggccctggtagagacctttgggggtctggaacctctggactccccatgctctaactcccacactctgctatcagaaact
				taaacttgaggattttctctgtttttcactcgcaataaattcaga
827	3823884	NWD1	YES	actgcagagccggtattccatatcctgggagatgcctctgatccttggatgtgcatggccgtgctggcctcccaggccacactgctgacagtgtccagggat
				ggtgtggtcagtctgtggagctcagctacgggaaaacttcaggggaagcaacatatgtccagcatcaaagaagaaacacctacctgtgccgtctcagtcca
				gaagc
828	2475018	FOSL2	NO	ctcagctctcacaggggtaatcatctcaagtggtatttgtagccaagtgggagctattttcttttttgtgcatatagatatttcttaaatgaagctgctttcttgtctttt
				atttctaaaagcccccttataccccactttgtgcagcaaagatccccgtgcaggtcacagcctgatttgtggccaggctggacaaattcctgaggcacaactt
				ggcttcagttcagatttcaagctgtgttggtgttgggaccagcagaaggcaaacgtccagccaacacacaggactgtaagaggactctgagctacgtgccc
				tgtgaagacccccaggctttgtcataggaggtcgttcagcttccccaaagtcagaggtgatttgatttggggaagactgaatattcacacctaagtcgtgagc
				atatcctgagttttacttccttatggcttgccctccaagttctctctctcatacacacacacacccttgctccagaatcaccagacacctccatggctccagctatg
				ggaacagctgcattggggctgcctttctgtttggcttaggaacttctgtgcttcttgtggctccactcgcgaggcagctcggaggtgtggactccgattgggct
				gcaggcagctctgggacggcacagggcgggcgctctgatcagctcgtgtaaaacacaccgtcttcttggcctcctggccagtctttctgcgaatagtcctct
				ccctggccagttgaatgggggaagctgctggcacaggaaggagaggcgatcccggctgaggcttaggaaattgctggagccggctccaagcagataatt
				cactggggaggttttcagagtcaaacatcattctgcctgtgttgggggccaggtgtgtcacacaagcatctcaaagtcaaaagccatctggggctgctgcttc
				tgtttctcaggctctggggaaaggaatctccctctcctctcacttgattccaagtgtggttgaattgtctggagcactgggactttttttc
829	2987324	—	NO	gttggtgcccaacatatgcctgcca
830	3379421	SUV420H1	YES	cgcctttccttcgaggagctcaaggcattt
831	3109159	—	NO	cattcagcactctcacgggatggacagagcagtgttcatgcag
832	2480318	—	NO	ctctgacgcacttgaggggttggctc
833	2841516	C5orf41	NO	gcagggatctagacgtcaggccaactgagagctgacagggaagagagagctagctagtatagacatagacatgagaatcagctcagctgctgtaggaga
				aagtcactgacagacagtagcatccaaggcatccagcgttatatgacccacgaaaacccccaaaattaaatatacacaataaaaggtcaaatgtttttcttga
				acaaaagtatatttatattgaaaacaatcaggtgaagagtagaccctaatcgccagtattt
834	3738805	FLJ35767	YES	ggagcttcttacctgctcacactgg
835	2771466	—	NO	aaaagagagcaatcctgcaagccaatcccgactctgaaaatcatcacta
836	3322962	—	NO	tggtggtgatgcttatagtggagagcctctaccttgctgcagctc
837	3906050	—	NO	tagatctccaaaatgacctctcacca
838	3119642	—	NO	ccagagaaagccgctgacagggaggagaggccccagcccctattacaaacccagccatcaa
839	3125570	—	NO	ccccaaaaccatctgcaacagccag
840	3933835	—	NO	ctgatggaccttctggccgcttctatgtttcttctctgattg
841	2802644	—	NO	gggatcacttgccacctgggatgtt
842	2854122	—	NO	aagttctgtgttagatagtcaagtagggtgactgtagttagcatccatgtattatatatttcaaggtagctagaagacttgaaatgttcccaacacagaaatgata
				atactcatgagataatggata
843	3147610	AZIN1	YES	gcaagagttgggtgtacctccagaaaacattatttacataagtccttgcaagcaagtgtctcagataaagtatgcagcaaaagttggagtgaatatcctgacat
				gtgacaatgaaattgaattgaagaaaattgcacgtaatcaccc
844	3398488	SNX19	YES	gggtgaacaaatgccggctgagctggg
845	3629947	—	NO	gaccagctctgatgggcaacccaaactcaagaagtgtaacttttctgcagaacccttcagaacttaaaagatcactgatgtaaggtcactagctggcacctctt
				cttataattacaattaaatgggcaataacttacccttacataatgacaactactattaaagagaaatcatggcatttgagaacaatgacataagattaaatcaagg
				caccatggctaactattcagga
846	3677823	CREBBP	YES	ttttgtgtgcgacaactgcttgaagaaaactgg
847	3101370	—	NO	taggtgccctgaaagttattgttgctttttttgttttttttttttcagtttgtgcgtgtcacttgaatcagaaaccaaacacatgtaaaaaaatatcatcctcaatgcccc
				ccattaactctctctccagaaggtgacaatgttagtgaactcaagactctcactgatgatggtattttacaatgaaaacacaaggaaaccctttgaggtccaattt
				tcacatcatattctccaaatagtaaaatagcagctctacatgttgatgaaaagaaatttcaatttcttcctatttgtttttactcatatcaacattaatatgtatctggatt
				tattaatttccaaaaagaaaattttagttaccaaatatttcagaaatttaataaagcattacatatatgtaattagcacttatctaccaaaaaaacatatgtgtatgtatt
				tatttatcttaccttcactgaagttcttttttctggctggacatgagaaacaggattaagtgatcaatgctggctttatttcttcataagcagtaatttgggtctttttcat
				tcaacacaacgcagcattttcataataaattcacaaaagacaatacaaagaaacacctactgaatagaactctgtcgagcaattcatgttttaaagttggactct
				ataccaaactggcattatggtattataggcatttgatttttgttttcttattttcagtttgtcagtttctttactaccattatttttttctagccggagataacgtataatca
848	2977512	—	NO	gccaagattagcatatgtgagtggcaca
849	2329726	—	NO	caagcacctcggtatagcattattactgaaaccacttaattcccagctttttgagttttttaaaaaaacccactgcactaagattcacaattcattgctacatacaaa
				ttaaagctagtaagaacacactaacgtcacaagtttctcattctaaagt
850	3626942	—	NO	tgcatgctcacagtaacacgtatactaaaat
851	3823576	RAB8A	NO	gcccacggccaccagaatgcaattgagaaatcgtttattttagtaactgtctgatctttttcaactttggagatggaataagttaaaaatttgctatttttcctgtaac
				atctgctgaacgggcccacccacacgttgtatattcagagagagagagggagtcaaggtgtgaccgtcgaccacagccagtgtcaggcctctgcctctgg
				gcctttgctttgtggcctcactgcaacacaaagctccaccaggaggctggttcacgtcccctaccacggaagcgaggtcccagaaggccagcggtggttc
				caggagcaacagctcccaaaccctgagcaaggcaaccgatcgccaggaccaggaagcatcacccaggagatttggcgcccacttc
852	3837475	GLTSCR2	YES	cggagcttcctacaatccatcctttgaagaccac
853	2802804	—	NO	tcgagtactatgtcttttgtggcactgaaaccttataacactatgatagctctgcttccacagcagtgaaaaccgaaagagccgggctgggcacctgcctcttt
				gaggtggaactcgggtcag
854	3410550	—	NO	atatctcgtctaacccctaccattgtgcctggccctttgaaatgtgtttcttgctgacgtgcttgtttctcct
855	2808525	—	NO	aaacagagtagcagttcagcccttatttgccttcaaaaaaagaaaagtacaaagtgttctctaattctggcttttagaaagttctaggaagttaaatgaacactttt
				ttttcactatgaattatatgagtgaattcatcagaacggctgcttctaagaaggattttggtggttttagaaaggtaggtgtttattcctttgcctgggaagcctcac
				cagagatgttgactctacaacccatctcattcgttagtttttgtggacagcagttgcctcatcgggaatttttttttttcacttccttaccatgtttcccttcggatggat
				agactagcc
856	3484743	—	NO	atttacactttaacaacttgctgggaatttaaacaacttgctgggaacatcctttgtgaggcactgtagcctttttttatttgaaactacttaaactccaagacaggc
				tcactaactctttttcaagtgcaacaacaaatgtgttagctgaaaatagctaatttaatgattatttgtgacacagacacgattatgtgagccaagaga
857	3765643	INTS2	NO	ccgaaggattttgcagtcctctgtcagtaacttccattgattaggcagacatattcaggtaaaccctaatcattaaaaaaaaattatcaatgtagaaagtaattcc
				cttttttctctctgagatatacctcaatcacacacttccccacccccacttgaaacagacctcttcacttgtgttttttttttttttttcctgaggtggagtcttcccctgtt
				gcccaggctggagtgcagtgggatgatcttggctcactgcaacttctgccacctgggttcaagggattctcgtgcctcaacctcctgagtagctgggactgc
				aggcacgcgccacctgtatttttgtatttttagtaaagacgggggtttgccatgttgcccagactggttttgaactcctggcctcaggtgatctgcccaccttggc
				ctcccaaagtgctgggattacaggtgtgagccaccgcacctggccagaccgcttcacttgtaaaagaaattaggctaataagaaggtgtagtttttgagaaat
				gaaatttaactttagccttttcactagtaaatagtcacatctcattttcttcctttgtaaaatggggttactactggccctacctcatattctatgagaatgagtttgtag
				ctgtttcaaatcatgaagtgcatagtatcacatgtgatagaatatttataactttttattagatgcttaatgttcaattaagtaattttgatgtgaaaaataaaagtaata
				aaagtatcttaaaaatagcataagaattttcatatttttaaacaaggcagttttgtagtcccttaagattaaatacaactgctccttttttttttaaactgaggccttgcg
				atattttgtg
858	3810029	—	NO	ctggtctcagctggactatcgctgaacagaggcgttggccgcacatccccttggaaggactctttgcttccacattcggaacactgtcctgct
859	2658003	—	NO	cttgaaatttgagcacatcccactgtattatttcactgtatggcaaaagtgaaggaggtaggcatgttctgtcatccttaattaagctttgggctgcttattgaagta
				tcattttttctatagattggaacatggtttatatagcagactatcttgtccactgacattgcccagtactgagttcc
860	2788748	—	NO	atgtagtacatttatgggctgtgat
861	3242486	—	NO	ctcagctacttaggcaggagaggca
862	3540024	MTHFD1	YES	aggggagtggatcaaacctggggcaatagtcatcgactgtgg
863	3439941	—	NO	tgttgggaagcagcaacaatcagccatacagctttcaag
864	3457676	CNPY2	YES	ttgtggaggaatacgaggatgaactcattgaattcttttcccgagaggctgacaatgttaaag
865	3843592	—	NO	gcctggccagttgtaactatttatcactgtctggactcataaacattttgagatgactttgggagtgcctggggagtttcattcagcctggtgcatatgggcagtg
				aaaaatatgctcatctgtgatagtagatgtggtttggttcacaaatccaggggctgggctttaaacggcattaggtggacagaggagggttgctacagctgag
				gtctcagctggtgcagcacaaaagtgaaatagggccatggctatctgaagccatatgtggttctgtgtggctatggagtcattccaggagacgttcacaggat
				gatttgggattaccactgctattgtaaaccatggaaattctgtgttaatattggatgctatttgtatttgtcaagcatagtctggatgcttatccacattttggtataag
				gccagaattgaaggcccaatatgatgtgtcactttgacatcttgtgaaagtgggacaaccttaaaaggtgtgagtacaaatctcattcccactctgctctcttga
				ataatgtatcctagcctaacagcccgttttatcaaggtgataaggcagggttccaggttgttatattttgtggtgggtttcaattccatccctaccagcagagttat
				ggaaacaaaccattgcatattcccaagggaatcatgggccgttata
866	2518951	—	NO	gcaaccctgcagtggtagtagtggtg
867	3187461	—	NO	cctgggaatattggcgctagagaacagtgatataatttgaggtgtctacaaatgttgtctaaaaaacctctctcctctcatcccatgtttcctctgactctactctta
				aaatctaggtatcactgggaagagtaacgcactaggcccacaggaccttagtattaatataaatgagctttagttttcaaatgtcatttttttctctataactggag
				aaattccattaataaaagaaccctaggggatagagggtagagggagcgagaggggagtaagggaggacacggacatacttaacactacctagggcacc
				taaccatcagaaatg
868	3730738	—	NO	ggcagataaagtacccatactaaaaagatgtctttagcttggttgaaaaataattgtcagtcctaccactgtgagttcaaagaacttaagaaaatacagaacttc
				aagcagagatatagaggattg
869	2898998	SLC17A4	YES	gtgagaagagatacattgtgtgttc
870	3397924	RICS	YES	atctaaagagctggtctacctcgtgcagattgcttgtcag
871	2494772	—	NO	taaatgactgtggactagtgcgcgttttttgttttcag
872	3322617	—	NO	catgacccaccgtacatgcatgggcatgatctgattttttttttaattaaagttgtcacagttatcaaagtctcatta
873	3735156	—	NO	taaaattgaaatgcaggttgggcac
874	2346360	—	NO	gtattctctttcatgtggtcagtgtatga
875	3757401	—	NO	caccagtttagcctttgagtgtgcagagctctgccctccctcccacccctcagccccaaatccaagatttcatagccctaacacccacccaagcagcttccct
				cacacatgccctttgttttcttcctctcttctatggttccttagggaaaggagccttctttagggatgaaaagctaactacagcccagtctggcctccagcagccc
				agggtcagctcagcctccactggaggcgagggaggagggcaaagggcatgggagaggtagggctgccctccaggagccttccccttccctaggagcc
				agtcaggattggggaggaaggcagaggggtcctagggagctgtcacatagaggaaaaggggctgggagtggggatgacaagaagtacaaagaaaga
				gaaagtttggggagatggataacaagctcagctgtgtcagtgatgtggaggggaggtatggtgggggaccagccatggccctatccaaccccaggctcc
				acaggccccaaattggctttgcaaatccaaacattttaaggaagtggtttagggatggaagagaaacacggtagaggtctgtgctgtggattttcatctaggg
				tggtgggaacaccagagatgtctcctctgccattgttttagttggctcctggacctcatcccagcagagggagggtgactgtcagcaggtcagtcccaccgc
				cactgtccccctcgcagtgggcctctgtgtctcaggcctggccaggctccctgcccctcagagctcctcgtggacccgctcctcgtcctcatctgacttcagc
				ttgagctcgtcgactgtgatcttgccgtcctgg
876	2386080	—	NO	gggcgcttttatgaggcatgagggaggcttgataggggctttgaaggcactgatggcaattggtgaagtagacttttatctaaagggggcagaga
877	3013608	—	NO	tttgcctcttcgagcttggcagtgcgagccacaga
878	3460675	—	NO	atgaacactcgcaggtggtcaggtg
879	2564601	MRPS5	NO	cacagcttgggatgttaccttgccttttgt
880	2939374	SLC22A23	YES	tgataatgcctggaaggtccatatcgctaagttctccttactggttggattaatctttggctacctaataactggatgcattg
881	3320209	—	NO	ccaccatgattgtgcttgccgggag
882	3852627	LPHN1	YES	gtgtaacaaccgcacccagtgcgtggtggtcgccggctcggatgcctttcctgacccctgtcctgggacctacaagtacctggaggtgcagtacgactgtg
				tccc
883	3349758	—	NO	aaacaggccatgtgactgaggagcaggtagcattcatattattcatatttcgagcttggtagatgtagaattttgcagtggaggccaggagaggatgtgagag
				ctgcaggacagaggcataggtttttggaggtggttgtggtgttccccgatggcaatcaacttcacggagagaagaggttattttctacttaggttgcctggagc
				cta
884	3427503	—	NO	aggtccttcaggtgccattaatttttcttgttattcaacacatattattgagcctctgtaatgtcctaggcttgttcaagatgttcagaataaagcagtggatagaac
				aggctttaaagccctgtactttattgcccaagtcaacgtccttagaatacaggtacctcacaactaccttgaggcttttattatgttattttcttctgcattcaggaatt
				ccccagagccaataggatacaattttaaaatgtcaaaccatttttgatctcataccatttggcttcagtccttctttccaactgtatcattgtctatttctaaataggga
				tggtctacactgtaaggctgatttgctcattgcccccacaaaatttgtcttgcattttctctgttcattcctgcacctgaaataattttgccactgccttctcaaagcc
				ctcaaaccttcaatgtctgggtcaaagccgttggctcccaggaagcctgttttagaaattaaatccccaagttcttttatctgcattgattatttaacacctgacagt
				tgcaacaactaagatgatttgagcgagataatgctccacattttttaccgtgtctgtgtttgtaggtgtgcccaactgacatactggctaagagttcagggtccca
885	3835463	—	NO	gtcctggatcatcaacttggttacaacatggtgttaacatgtgggactgattgtgtttcttgttaatatttctgtttctcccaaccacgctgaatatt
886	2809576	—	NO	tcaaatctatggcttaccagagagaagaccagagcgcaatatctccgtggccttagtcctgact
887	3601075	—	NO	atgggccaaagctggggcacaggaaa
888	3864620	C19orf61	YES	gacttatgttttccgggcccagagcgctgaaatgaaggaacgagggggcaaccagaccagtggcatcgacttctttattaccca
889	3888182	CSE1L	NO	ggaagttctccttttgaacttgtcacgaattccatcttgtaaagg
890	3558243	RIPK3	YES	cttcgggatcctaatgtgggcagtgct
891	3702633	—	NO	tttactcctaagcaccagtgatgacctcgtcaagcagggtgggctgcagggagatgacagcgggtatgaaagggtgtga
892	3433106	—	NO	tagctcaatgcaaccgacgtttctgagcccccagaatctgatccagatcccggacatataaaccacgccaagaagacaggggctgtctctagcacattctct
				cgagggagtccggggccccttcccagacgcaactgcaaaaggaagggctaacgccatggcgggcccgtggtttattttatatccgacaaagtgcacggc
				agcctgaactggactggaatgaaaagacgtgtctgggacgggtctacggggacgcgctgcgggacctgtccggcttggcttccaagccgctaaccaacc
				gctggatgctctgcagttcgctggtggccgcctctttctccgcgcagagtttgggcgacaa
893	3544695	TTLL5	YES	ggggcggggcgtctacctgatcaacaat
894	3219716	—	NO	gtggcatctctgcttggaagtcctattcttagtctcagcttcagtacaccctcaagctatcttatttgcttctaaaaatctcttctagtacttctgtttcagtctttgtata
				gttcctatctgttctttggatattaattatgtatagtcacgtatatatactgtgcagacttatttagaggctttttgtcatattttgcttaaacctgctactgtgcaatctta
				cattccagttctttcattagtatggtctttttttttcctttctcctctcttctacacttctattctacttttccttcttggtccctttgcgtagcatcttttgcctggccatctca
				gttttatcttttaagtcctttttctttgttcatcccctgcttcagtgagcttttgcttctctgaactttgataacaagtattactgaaccatttatttctgggtgtagaattca
				tccaaactgagcttttgagggaaccttattggttatctaattcattctcctggccagtacagctgtcattctctgaaacatccatgacagtatctacttgaatgtttaa
				tggacatctcaaatgtaacgtcagagactgaattccagaccttcctccagttgtctgttcttctcatagtc
895	3442242	ZNF384	NO	aaggagaaggaataagacggcaggagg
896	3293761	—	NO	accctccttaccttgtccttagatgcttaacatttttgtttggttttcttataaaaataacagatcttatgaaggtagaggtcagatgctgaatgagcgtctggcaaa
				agtgggatctgagcagctgatgcgggctgccagggccaagccaaggttgtccccaaggcctggccttggagggtcccccccgaccggccctgtccctg
				cccttgctccctgggaggggacggtggatgggtgctgctcacacccacaaggcttccctgtctagtcacagctctgtgatctccaggggggtctccatgatc
				acgtcgcgaa
897	3829701	GPI	YES	cccaggagaccatcacgaatgcagagacggcgaaggagtggtttctcc
898	3539958	SYNE2	YES	agtgagaactacagaaggcgaggagg
899	3620286	EHD4	NO	ccctatattattctatccgtcctccag
900	3621069	—	NO	atgaatccacctaaaaggggcagaggca
901	2496816	—	NO	ccacccatgggaagctgatgagttttgtgtattgaattcgaagagcagagaatgggggaaaaggagattcccccattgaaaacctagataatgagagaggc
				ggaaccaaaagcagactcagaacttcactgagaataatgggggtgtagtagtcaggtgagagagactggactaccaaatcatcgttgctatccagtta
902	2644239	—	NO	tgaagaccagtcgaaggagtgcagaccaggaaaagcgggacgttgatttggatggga
903	2832085	ZMAT2	YES	tggactttcgccgaaagtgggacaaagatgaatatgagaaactcgccgagaagaggctca
904	3757844	STAT3	YES	tgctgaaccctcagcaggagggcag
905	2943556	—	NO	cctcatctgctcctactaccttgca
906	2459948	—	NO	aaacttttctcgatacccttctgtgatgactt
907	3119958	GRINA	YES	ctttgtccgggagaatgtctggacctactatgtctcctatgctgtcttcttcatctctctcatcgtcctcagctgttgtggggacttccggcgaaagcac
908	2567115	—	NO	cctgattagcatatcacagtgctctaggagtcctggaacgccttcctcttccatgtgcactgctgctgacatccaggccattttggaacctgcaaatgtctcttccc
909	2893649	—	NO	taagtcttagtaactccgtgctggatgtgcattttgcattcagcttctttatcataagggaggaacaaagactggggctcctgctgacatctgcagacacaaag
				ctgagtcggaatttgtggtcttagcttcggttcagcaccaagtgtatttataagtttgcagtcataggttttgttgtccaaatcccaacaaagccctttcccacctcc
				accccaccccggaagttatatagggttccttgaagggacaaagcctctagaaaaagaaaagtcactgaaagttgtaatgtgaaaccagcaaagagaaaata
				catgtttggtttagttgtggtcacagtccatggtg
910	2346547	—	NO	ccctgacagatctcggtctggggcacagga
911	2852745	AMACR	NO	ctggagcttccctggactcaacttcctaaaggcatgtgaggaaggggtagattccacaatctaatccgggtgccatcagagtagagggagtagagaatgga
				tgttgggtaggccatcaataaggtccattctgcgcagtatctcaactgccgttcaacaatcgcaagaggaaggtggagcaggtttcttcatcttacagttgaga
				aaacagagactcagaagggcttcttagttcatgtttcccttagcgcctcagtgattttttcatggtggcttaggccaaaagaaatatctaaccattcaatttataaa
				taattaggtccccaacgaattaaatattatgtcctaccaacttattagctgcttgaaaaatataatacacataaataaaaaaatatatttttcatttctatttcattgtta
				atcacaactacttactaaggagatgtatgcacctattggacactgtgcaacttctcacctggaatgagattggacactgctgccctcattttctgctccatgttgg
				tgtccatatagtacttgattttttatcagatggcctggaaaacccagtctcacaaaaatatgaaattatcagaaggattatagtgcaatcttatgttgaaagaatga
				actacctcactagtagttcacgtgatgtctgacagatgttgagtttcattgtgtttgtgtgttcaaatttttaaatattctgagatactcttgtgaggtcactctaatgc
				cctgggtgccttggcacagttttagaaataccagttgaaaatatttgctcaggaatatgcaactaggaaggggcagaatcagaatttaagctttcatattctagc
				cttcagtcttgttcttcaaccatttttaggaactttcccataaggttatgttttccagcccaggcatggaggatcacttgaggccaagagttcgagaccagcctgg
				ggaacttggctggacctccgtttctacgaaata
912	3659213	—	NO	acctccaaggttacagcactttctaagaatgtgcctatgtagcatgtctgtccccccactgcctccaccaaaattctgagaacaaagacactgtagggattgaa
				cctgaagagtattcgctggaatggtatgctaaggtttctttcctgctgtacacctcctctgccccaacaaggtgctttaagttctgttttttaatttaggaaacctgtt
				ctgctattatagaaggccatgaaaagagaccagtgatttatctaatcataagcaaaaatagtagaaggctattgtcttgtcacttaagttgaatgaatcccagtg
				attgtagttgcttcacgaaaaataaccaatttgttctacagaggtagtctgttcccagagattgaaaaaaaaaaagatgtaggaaagtttaaataaataaaattgt
				ttaaattcacaatggagggccaattcacatggccctctgcattttgatgtaattctaacagttttactagcagaatctaacaaattttgaaagtcagagcgtatgta
				tagatatatatacacatgcacacatttttttaatgatacgttatccacttaaaaaaaaaagtctcaagaatgtcataagaaactcccttaacctcaatgagcctcag
				gtttctaatccctaaa
913	3296517	POLR3A	NO	ctcatgtaacctgggaagagccataaaggggtaccccccaccccaactgccttcctggaagcatgcctgggaagtaagctgtaggcctgatccgagccag
				gaccactgggatccgtgcaaaggccaggggagggtagaattgaatcataggagtgaactccggcacctgttgtcttctgcgggtgacgcacactttaaatgg
914	3028090	—	NO	cttggtcgtcacattctgcttttag
915	3291113	—	NO	aagatctttgagttgtacttggtgtgtgctgtttttgtttgagatgcagtgaatgtgcaaatagcccagccgtaaatagttacttaaaataatctcttggtactgggt
				agcagcagtagaaagttgatctgttta
916	3616816	—	NO	gggccgaaactgctgccgtgcattagctctgtggaggggagtcataaattctggttgtcagcgttttccgtggctttgtg
917	3842744	—	NO	ctccatatattagctggggctgccataacaaaacatcatagactgggtggcttaaacaacaatttacttctcacagttctgaagtctggaagtctgagaacagg
				tcgccagcatggttaggttctcgtagggttctcttcctgttc
918	3956320	PITPNB	YES	tcccgagggctccttggtgtttcatgaga
919	2473315	—	NO	ctgggctgccaatctcttgccttgggggcagagcctcatctctctggctactggggttagctaccttgttggagctggcaaagccattggtgttgacatcggg
				ggtgactcctgaagccgccatatacgtgctgccaatggttttgatcttggtgatcacccggaacttgggattgtccaggagctgaggccaggattcaggaaa
				gaattgtcagcagtcaagggagaggaatgacccaacccagtgacagatgtacctgtttacaaggaccccactaaacccaagagacactttcctatcaaagtt
				gttacttagtctaccgcttatctgccacatgatcctgggagaacttc
920	2659117	—	NO	tgcctacatgctccttctagctttgtttccctgatgttccttgccacctgctactcctctctgagctacttttccaggttccacagggagaggttcagctgtccgtgg
				tagacatgagggtagagaatgaggtggttgggttccacttacctttctatcatcttgcagtatggatgtctcttgactggtaccgtgta
921	2826873	—	NO	gatatttatttgggtgcatgtttcct
922	3498544	—	NO	tggcgtctgatcaggaagggactctgctgcggctgtggatctgacctgggtatcagatggtgatgctttgtaaatagtgtgcctcataggggtctgttcttagtt
				aaaaggagcctgcttggtgattccttttg
923	2756844	SLC26A1	YES	caggccatcgcctactcattgctggccgggctgcagcccatctacagcctctatacgtccttcttcgccaacctcatctacttcctcatgggcacctcacggca
				tgtctccgtgggcatcttcagc
924	3088854	—	NO	atgtgccctacccagacagtgcctg
925	3173548	PGM5	NO	cgggagatgcttcactgatgccttcttgctacctgtttgtgcctcttatgactttggaaaaacaaaagatattttgcttttgggggatagagggtgggtgggaaaa
				gaaaaaaaatccatttggttttggttttgtcctattcctccaaatgcagcagggcctttagttgtctgttaaagctgcactataatttggtatctacattttatcacaca
				aaggaacctccccttttgacaacaactgggctaggcagctgttaatcacaacatttgtgcatcacttgtgccaagtgagaaaatgttctaaaatcacaagaga
				gaacagtgccagaatgaaactgaccctaagtcccaggtgcccctgggcaggcagaaggagacactcccagcatggaggagggtttatcttttcatcctag
				gtcaggtctacaatgggggaaggttttattatagaactcccaacagcccacctcactcctgccacccacccgatggccctgcctcccccatcccatccccaa
				catccctgtaccaccttctctcacatcttctaaagctttgtacaaatcacaatggtgcacttccaacaaaatatatcaataggtgttttcctctcttattttgtaaatag
				tattattttagctattaagctggataccttctttcaaattcagccattcagttgtaaagttgggaagaagtttcttgacaagactctgcaattaaatgcttaaaatttgg
				aggggatccttccttgattacatcaagtatgttggtacatgggtttatacaagttcctcttgagaaggcaaaaagaccaccatgtgtgagagctctttgacttgg
				ccaataggggcctatcttaatgcacttgtttggacacatttctgatcttatttgtaaaggctgcaaaaggagaggatgaaatgctgtaaaagtaggaaatgaagt
				ggaagctggaagaaaatgtaattggtggtacagctatgggccagatggtggaggggagggtggggacccctgc
926	3200057	BNC2	YES	tccctcccaaccagtcccatcattccaaccagtggtaccatagagcagcaccc
927	2974443	MOXD1	YES	ggccatgagagtctggtgcaccacatcctgctctatcagtgcagcaacaactttaacgacagcgttctggagtccggccacgagtgctatcacc
928	2385905	—	NO	tctaaaaggcgtggaaacatttataagaaataccaattatgcagtgttggtgtcagtgtggacttaactgccgagactgacttattgccag
929	3639566	—	NO	acaggttatttctatggacaggctcttgacagaaactctgaacatggatattactgtccccttcattcaaatgaggctgaactgaggctcataagtatttaactctc
				acacctagttaacacagtaagatttgaaaccagatatatatgaatccacgaagtcttatctg
930	3200565	—	NO	tggcatttcatgaggggaggcttatctgtgg
931	3083781	MCPH1	NO	atgtagtggcctatgttgaagtgtggtcatccaatggaacagaaaattattcaaagacatttacaacacagcttgtggatatgggggcaa
932	3829376	—	NO	atggccgtcgtcaggagcattgtgga
933	2359017	—	NO	gtaaccgggggatcttgcttgtcagtgcctggac
934	3180982	HABP4	NO	ggggagacttttccagctgggccaagggagtcagactctaagaacaatagatgttgcttttcccgtgtcatgtaaatttgttgcacttttttgggctgagctgtta
				gaggggcttctccagaggctcgagagcaggccatttcccaagaagatgaagaatggtgactgtgtttttattgaaggaatttcaaatgaagaataatgtttaaa
				atgtgtatatagagatagtatagactcctccgcggaagcatggagggaaaggaggttgtaaaatagactccatggagactcttaggaagcagtagattcccg
				ggggctgtgcctttagcgttagaggaaacacatagagctggaactgttaatggaaagcagtcacagctgagttttcggagaccaa
935	3915249	—	NO	ccaagctgtagatcttcccaagatatttttcaggaacgaagcatgtaaacttacatgagtgaaagacagtggtaaaaaaaaaaaaaaacagtctattttgggct
				ttggctcctacctaaatctagcttgtt
936	3263765	—	NO	tgcagagtcctacagctggttcaaggcagcatcaggctcagaacccctttctctcagctctctgttgtgattatttcaggaccttgttctgttttccacatggcctc
				taatctagacacctgacctggtgggagtaacctttca
937	3303272	ERLIN1	YES	ggagctcaaaaagtaccaggccattgcttctaacagtaagatctattttggcagcaacatccctaacatgttcgtggactcctca
938	2683681	—	NO	ggtgacccaggcacgatagctaagaaggcaaagtcgcttgttctattagctgtttaggcatctttgcagccatccttgatttggagtttttgatcttgatctaattct
				atccctcaaaaccagcccttacaatctcacgtgcccacctcttccatgacagtccttgggcctagagggagggtgattgtatagttttagcagcagggcatttg
				cagtgaaaaacagattgggcccagtgggatgccaaatgagagagggtcgcatct
939	2683865	ROBO1	YES	tggtgtgtggcttcatacatttggggaccctatttccactccctcctcttggcatgagactgtatacaggatccacccgag
940	3781116	—	NO	ggcagctgccctgtaatgttctaccagtacttcagactcaacatgcacgaagattaa
941	3050281	—	NO	atgctgcccttcgatgaccatagtgaatgttccacagagtgtactacgagccacaaacaccagggagagaaccccagcatcagtggagtagaaacaaaaa
				ggtgttctgtgtttcgcacttgggtcctg
942	3903591	—	NO	atcggcatagcctagatgggtcttctgtttcagggtctctcacaggaggtagtcaaggtgtcagccagggctggtgtctcatcttagcgcttggctggggaat
				aatctgtttccaaactaacttggttggtgacagaattctcttcttgaagggatgttgaattgaagggcttggtttctcactggctgatggctggaggttgctctgaa
				ttcctttccatgtagcttcttcaacatcacaaagctgagaaaggaatagcaagtctcctaggaagatggaaatcacaattttttataatcatggagtggcatccta
				tcacattttccatagtccgttagttagaagcaaatcaccaggccagtccatactcaggagga
943	3115066	—	NO	gtctaggggttacaggatcatcatctaagttctgcttctgcctggacttgctgcgtaatttgaatgagtggctaaacctgactctttctcctcttg
944	2509773	MBD5	YES	cactaacagaaggtttggaagcctacagccgtgtccggaaaaggaacaga
945	2322410	NECAP2	NO	ttctctttggtggtttctaaagtgcct
946	2837342	CYFIP2	YES	ttttgtgcggactgccattcctttcacccaagaaccacaacgagacaaacctgccaacgtccagccttattacctctatggatcc
947	2936910	—	NO	ttaaaggtgtagagtaagaagaatcaataccgtgtgttggatattaagcaattggtaattaatcttgcttcctttatcttgacaagatgtgctttttcacttac
948	3958553	SYN3	YES	atccttcaagccagacttcatcctggtccgccagcatgcctacagcatggccctgggggaagactaccgcagcctggtcatcggcctgcagtatggaggg
				ctgcctgctgtcaactctctctactccgtc
949	2901722	—	NO	acagtaatggaagacgggagttgcagtgctcagtcatggaattcctccta
950	3092902	NRG1	YES	ccaaatgagtttactggtgatcgctgccaaaactacgtaa
951	2437102	KRTCAP2	NO	tgccacgtgctcagaaattcacagcagatgcaatctcatgtaaaaccctcatgtggtaaaacaaagatctatcatggttgcccttaatcttttctcttttttttttttttt
				tttttttgagacaaggctttactctgtcgcctaggctggagtgcagggatgtgatcactgaagccttgacctggtctcaagcaatcttccctcctcagtcttacca
				gtagctgggactaccagtgagtgccaccacacccagctactgttttaagtttttgtagagatggggtttcaccacattgcccaggctggtctcgaactcctggg
				ctcaagtgatcctcctatttcagcctcccagagtgctggaattacaggtgtgagccactgtgcctggctgccctcatttctttgcccccctctaggacttgctttct
				ccgcatagcccttttgcaggcttcagagttctttccatccagtagccccgggacttctctctgttaggttttg
952	2657991	CCDC50	YES	tatgccgagattttgctgtcctggag
953	2520359	—	NO	ctttgagcgatgaaaacagtttttatctttttagcaaagttgtagttaggatcttctgtctgtttttaggggtctccactggtattaaaggcctga
954	2592274	STAT1	NO	gctgaggtttagctgtcagttctttttgccctttgggaattcggcatggtttcattttactgcactagccaagagactttacttttaagaagtattaaaattctaaaatt
				ctattaatctctcattaatagtatttaatataaagattcttaaaattactgacgttatgaattggtttgatgc
955	2681309	—	NO	atcttctaagtgtccatgcagcttgaatcattgcacacagtcttctatgagttatgaaaataaataaaaccccctcttttccccattttatggttgtgaaactgacac
				agataacacaaaagggtagattagggaaagccatatcccctctgccacccacctccaatactgatccagctttcctggatcaggctagtagggcgttgaggc
				ttcttactagaa
956	2961267	COL12A1	YES	ttggaatccatctcctagtccagtgactggctacaaagtcatcctcacaccaatgactgcaggaagccgacagcacgctctgagtgtggggcctcagacaa
				ccacgctcagtgttcgcgacctctcagcagacacagaataccagatcagtgtttccgccatgaa
957	2854242	RICTOR	NO	ggctgcatcctattaccacaatggggtgtgctataactgctggtattagagagggaactttggccctttcacgtttttcttaatgtttgtaacactacttcagaggtt
				tataacctcaaagcagaagaagagcctcaacaacccgggacttataagttatttttatgttactagacttgcataaagattcttgttttccaactcttcattttgttgc
				aatgtgttattacaggatatatgaaccaattaaggtttttcactacagttcttgaataaaatttaaaaatcattttttattttaattaaaaatatttcccatttatagaatgc
				atatatttgcaatggacttccactttcatcaactttccatctcatcgctttaaacaggaacttgaacaagcactgttagtttagacctaaaggataggaaagcatta
				aataatactttggatctcctgaggaaaagataagtttgcttgcaatttacacattccatggggaaagaagagccatatttccttaaaaaaaacattaataaagctt
				gttattgagaaaaattgtagtgaaaagccttaagtaccaaattttaaagcagcagtaacttaatttttatatcagtgtttttgttttgcacaaactaaatgcagtggta
				ggtgggtttatgagtatattaattgcctttatccatttgtgaagttaagttgatgagggcaaggtttttgtttgtttaatttgtatatgtctaaaggtatttggaacttttta
				caggaattaaacatatatgcaaatttgtatataaaaatagcatggccatcatttgaatgcttgtaaatgaaaggattatcttttttgagatctatatataaatagaaat
				agaaaatccagctggactgattaggattcttttttaattcatttgtgtataacatttttattacaattacacatcagttttgacacagtcatagcaacattaatattttccc
				atgatgcagatcctttttgtaatgggcttgttctttga
958	2957263	—	NO	tggggaggcacataacagttttttattctgggaagagccagttccccactcaacatattcaataggcacagagaccaggggaccacggaaagctccagtga
				cccccgacccccgccaactcttcctaacaacatttgactccttgccctcctccgttggaactgtgcttcctggaaggaaagtgattgaagaagaagagatgta
				gttctgtaaaaggcataaaaacagcttgtttttttaaaaaaataatatttttctgttatgatgcaaattttttcatgactcttctttctctcactctccacagtcatttcatc
				ggcaggtcctgccagctctgcctcccaaacacattgagactgtctgctgctttctgcctgcaccaccaaccctagtctagtgacctttgaccaggggaga
959	3429874	OCC-1	NO	aacagaagaatccgtaacagaagatgaca
960	3766915	—	NO	ctcctccattgaagcagattgattaaaacagcttaggaaagggcaaacttggatcacgagcagtggatttttttcatatctgatagtgaatttaactttttcatttct
				ggcgaaattaaagagatctgtgaccaaaagtggtcaagcactggagtctga
961	2691040	—	NO	cgcactggcattggaacataataaactaaaattaaaatgtttctttactgtgcctcaccattgcacaatcaaaaaaaatttttttgcatacactgtggtgaaataatt
				tttaaaacttggacttgctactgtgaagactgatgtttaaagtttataactgtataaacattttctatgtccccccccacaccatggatttcttataacattggatatatt
				tttccttgctggactattctcttttggattga
962	2824389	DCP2	NO	agtgcactgctttcttacaggaagacaactcagaacacacagccataatctgctttggtgtcagtcacatcacagtggttatacatttgtcctgaatggtgattca
				ttcctttccatctaacttccttgtgacaaatagcatttactattgaaatagtcttaaaatagggaaaagagtgaaagttactcttatgcatgggagtgggcttaaag
				ggttgacttccaccagctgagtacaaacaagtgtaaagaaaaactatgataaagtatggaggtcttgagaattgttcataatgaaatctttaatctgggttatca
				gagtaatgaaatcaccaataaaaacattccatttatcttggatcttctgtggttagcagaggagtatggtctagctatgttagcagcttgaaggcacaacgtaaa
				aggaatgagctttcacaaggtgcttacgttagctgggtagtattggtcaaaggtactctgaagagtgaatgcagaaatcagttggctgtgtttgtaatcttgtcc
				cacatggaccctaacctttagtagacttcagtcttttagtccagtagaagacaatggccctgaatatgtgttttctgctttttggtggaaggtttcctgcaggtggtt
				gggtggtttttgggttattggctactgttcgttcagtgccatttgaagacctgttgtttcttaatcctttttcttggtgtgactggccaggaaaaagtccattgagtcct
				ttttttctccctggtgtcttaccccttctgtagaataatccatattttaaaatttgtttcacatcatttatagcaaacctgccacagacttgcaagcagtgattttatctttc
				cttcctgagaaggtgatctcacttttgatgtttgggtcacctgtggacacctgtgctcttttgagtctcaaggcttatagctttcacattggcttgggaacaacaga
				cttgtgtgtggttctagagtgaaatgggcagtgttctgctggtcctcagtctttgagag
963	4054485	GABRD	NO	ctctgcaggatcgggatcagagcgtgggaggaggtgggggtggacgtccatccggtgaacagtga
964	2871027	EPB41L4A	YES	cccggcctgatcagaatgtgacaagaagtcgaagcaagacttaccctaagcgaatagcacaaacacagccagctg
965	3468170	—	NO	gctgagcccataacctgcgtcttctgctctagcctcttgtctgtctcattcctcctctgcatggattgtctctatttggaaggtccgtggtttttatgtgtaaaatgaa
				agctgccgtgttccctttccaacaccaagtctagttctctagctcccattctatcagtgtcatacctcccagcttaa
966	2739471	ENPEP	YES	gatactgcattcaaacgaaacatgtggccattctctgtgcggtggtggtgggtgtaggattaatagtgggacttgccgtgggct
967	3725508	—	NO	ccagtgctttgcactgtagctgctcaataa
968	3946498	MCHR1	YES	ttcgcggtcgtgaagaagtccaagctgcactggtgcaacaacgtccccgacatcttcatcatcaacctctcggtagtagatctcctctttctcctgggcatgcc
				cttcatgatccaccagctcatgggcaatggggtgtggcactttggggagaccatgtgcaccctcatcacggccatggatgccaatagtcagttcaccagcac
				ctacatcctgaccgccatggccattgaccgctacctggccactgtccaccccatctcttccacgaagttccggaagccctctgtggccaccctggtgatctgc
				ctcctgtgggccctctccttcatcagcatcacccctgtgtggctgtatgccagactcatccccttcccaggaggtgcagtgggctgcggcatacgcctgccc
				aacccagacactgacctctactggttcaccctgtaccagtttttcctggcctttgccctgccttttgtggtcatcacagccgcatacgtgaggatcctgcagcgc
				atgacgtcctcagtggcccccgcctcccagcgcagcatccggctgcggacaaagagggtgacccgcacagccatcgccatctgtctggtcttctttgtgtg
				ctgggcaccctactatgtgctacagctgacccagttgtccatcagccgcccgaccctcacctttgtctacttatacaatgcggccatcagcttgggctatgcca
				acagctgcctcaacccctttgtgtacatcgtgctctgtgagacgttccgcaaa
969	2818169	—	NO	agacacagacgggtggacccaagcattgagggc
970	3092610	UBXN8	YES	ttttgctttgtggccggattttgctactgcttgctcttctta
971	2560754	—	NO	gcccgctatctgcatctgccttttggactccttgggggaaataaaacaatcgtgtacagttgggaggctcttcgttttcaccatcagttgactccatcagt
972	3850324	—	NO	gagttcagggagacgccagacaattgcagcagtttgtagagttatgtgggtcaggctaggattagttttgctgcaggaataagcaatccccccaaatcttaat
				caaggtttacctaaaatcggccgagcaca
973	3209807	—	NO	cttctctgaaaagaccagcggccctatgactatc
974	2639722	KALRN	NO	ccttcttctctactgggtgcaattcgaggttgctgagcttctctccaaagtctaaaatggtggggcagtagggacctgtgagaggcccaatggcccaatgtact
				tcccccagatcccactcagaacagcaggtacgcccaggctcctgctgccctagaggtctgcaacatgagtgaagaggttaattagagggacacacttatct
				ctgaagtttttctccaggctgaacatttctattatcagtggcccctaatctggaaaaacccatcattctaatctagcttgtatccccacatcatgagaaagaggga
				agaagaagaagggatgatgtgtggtagagaagatgagggttaactttagcctttcccaaacactggcaacaaccacttcctcaacaatttttctatttgcttcag
				cctactcagattttttcaggtttttctagctcctccataacctcactccctcccgaggtctctggttcaaagaccaccctaccagcccctatttgcttcaggttatcc
				tgttgagggtgggtgggaagagtgagaagatataaatgaaaaactggccacatgttgataattgttgaaactagatgatggtacgtggacattcattataccat
				tctccccacttctgtatttgtttgcaatttttcataataaaaaagttttaaaagtcctccagtttccaacacactcaagagagagccccaaccccaaacacagagtt
				tcatggaaaccccacaccaaggcaagaggcagagatgatgattccatttcatatatacactcattttctaactttttttaaaggcccactgctttattttcaatagat
				taaacctgatttctgagaggtcctgaagttgggcttatttccctggc
975	2972483	—	NO	gtgatgactatgggccaggacaaca
976	2518314	ITGA4	YES	gcagttggtgcttttcggtctgattctgctg
977	3680796	—	NO	tgtctgcttcaacctcacacttctctcag
978	2329274	—	NO	ctgtgggaaggactcttctaggttttggactctctaattcttctgctgaacccagtgactgtgtaaacatccagaggcccaccccacccaaagaatgtcagactg
979	3379673	CPT1A	YES	ttcaggcagcaagagccggcaacgccatccatgccatcctgctttacaggcgcaaactggaccggga
980	3549257	—	NO	tgagtcctccattccaaactctcct
981	2360474	FLAD1	YES	gacatctagggcctctgaactttctccggggcgcagcgtgacggctggcatcatcattgttggaga
982	2584988	SCN3A	YES	aaaataagatgcgggagtgtttccaaa
983	3630231	LCTL	YES	tcacatgcaaatggttacggagatcgtggtacccactgtctgctccctctgtgtcctcatcactgctgttctactaatgctcctcctgagg
984	3801606	—	NO	ctggtgccagggctcctctcactgccctacacttgcagggaggtggacttccctccc
985	2476381	—	NO	agcatcacatattcaggggaccttgaaaagtttggtgtgcctgagcatagtgtagctggaaggtagtggtgggagatgagcctggagaggaaatcagggg
				ctagaagataaacaggaatatatcacagagttacttaccttaaaagtaatgttgagccactgaaaggttttcagcagctctcatcaggtttgcattatagaaaga
				tggtcttcaggtgtagttgaatggttggaggggaagttggaacaagaccaaactaccatggaagagactttcatctgttttgtctcagcagatagagctgtatat
				gtcttctccctgtcctactgttttgggggactgagattttggtactcatcagcactcttgctctcatattatgga
986	2522188	LOC26010	NO	ggtgctgacccaattcgctgccaaaagagtgtcaatcagaatatacaaatcccgtatggttgtgtcatcctctcttaatcatttttactaattctaataatcagctct
				agcttgcttcataattttcatggctttgcttgatctgttgatgctttctctcatcaagactttgcagc
987	2673516	UQCRC1	YES	atgccagtgtggtacgtgagatctgctccaagtacatctatgac
988	3659195	—	NO	gaagaagcagtgcatctgggtggca
989	2652475	—	NO	tctgtccctctgctagttagttctgtacagttatccccacagtcctcttcctaaagtagacattactttcttgttcaggtctagagttggttgccttcgcatgtagttaa
				agttctgtagcatggtgtataatatccataacactcaaccctgcttacctctcaagaggcacctttacctgtcaccccacagtctatgtgttaaatttctgttcccta
				gataccttgggcctctttctaaatacacactttcatgtccattatttccccctgtctggaatactctagagcctttcattgacaattcacttgttctttttggtgcccctc
				ctcaatgtgacccttttagaaccttcatcacagaaatagttgttctgttttttcagcatctgtgattctttccctccctgtcatagaataaaatgtgtatttatagtcatc
				accaagaactcatattgcctcatggggattgtatctcagcatc
990	3198107	—	NO	atgaagcagcacaggtacgaggtgcaag
991	2994022	—	NO	gtagattcgatgggcccgaggctcag
992	3548367	—	NO	tcctgttttctgcattagctgtttgcatgtatttagtaggttagaggtgggaactagagatcagagaattgtttatggcagcagagttagcagtaacttgagaggg
				catagctaagtcaaagacctact
993	2440185	COPA	YES	ccaaaaaggtacaggtgcccaactgtgatgagatcttctatgctggcacaggcaatctcctgcttcgagatgcggactctatcacactctttgacgtacagca
				gaagc
994	3480073	—	NO	atggggcttatccttactcgcagtcacctaaaag
995	3513910	KPNA3	YES	ggtccaattgagtgctgtccaggca
996	3978139	—	NO	gaaggcctcggcaaaggactgtgct
997	2540091	—	NO	cagctccagggtgaaatggtgctag
998	2896688	—	NO	tcccgagggctgatcactggaaacagggcaacctctggtgacctggtttttcatcaccagccagggcagaagaagtcaaagtgtgctcaagggctttgcac
				gctgctccctagaactgg
999	3022504	—	NO	actgtcttggtgttggtcaggattaatataagggagtg
1000	3104044	—	NO	atggcctgaaagctttaggtggtgcaacacagggtgaa
1001	3939535	SLC2A11	NO	caatcaatggtgagcgtggtattccaggctaaaggtaattaactgacagaaaatcagtaacaacataattacaggctggttgtggcagctcatgactgtaatc
				ccagcactttgggaggccaaggtgggaggatcaattgaggccagagtttgaaaccagcctaggtaacatagtgagaccccctatctctacaaaaaattttaa
				acattagctgggcatggtggtatgtgctaacagctctagctactcaggaggctgaggcagcaggatcacttgagtccaagagttcaaggtagcagtaagct
				acaatcacaccactgcatgccagactgggtgacagagggagacttcatctctttaaaacataataataataattacagactcaggaaatgcagtgaaagaaa
				aatacaggttggccaggtgaggtggctgatgcctgtaatcccagcactttgggaggccaagatgggaagattgctttgagaccagaagtttgagaccagcc
				tgggccacatagtaagatcctgtttctaccaaaaaaaaaaaaaaaaaaaattagctgggtgtggtggtacatgcctgtggtcccagctactcaggaggctga
				aatgggaggatcacttgagcctgggaggtcgaggctgcagtgagtcctaattgagccactgcactccagcctggacaacagaaagagaccatgtttcaaa
				aaaaataaatacaggttgtagtgggtatgggtatgcataccaggaggcccgacctcgtctgagaggggagtggtcagaaaagaattttctgaggaattgatg
				tttttaatcaactttattgaggtataatttatacataaccaactgcatccattttaagtatatatttggcgagttttgagttctaagtatagttttggtgagtgtatacactt
				gggaaacaccaccgtgatcaagatggaacctttaccctaccccaaggcacccacatgcccatttgctatcagtaacccaccccagtcccagacctggg
1002	2420794	—	NO	tagatctccacatgataacctgttgaactttttgagtatctgttgatcaagaaaataaagtcaaaagctacaattaattagtaatgtgctcaaaataaatttgtatttt
				ataaatcataacatcttttccatgttactctgtctatatggagttcttaataccacacatttgcttagggagatggaattagcaactagtctgtgctaccctgtatttttt
				ttttaaccatgtagttggattttttaaaatacaataaaagagttcacttttccaggtttgacaacatttttatgaattggaaattttctgtggctacagatactattaacat
				tttggaaaggtgtaaagaacattgttttaatgtaaggctcttctctaacctccctcccctctccaaattctccataatatgaagtaggaagatatgtatttttctgttg
				ccattaaaatgttctggccatcgtgggagtggggatggggagggcggggatgggaattagaacttactagaataaaattccaaatagaggtttggggaaac
				ctacttgtgagtgctttttaacctcaaaataaggatttggggtgggtggagaaggtgatggggcagaagaagttgtttttggaggagagaaagcagattgaaa
				ggaaaaggacagctgatagccacttaaataatgtcatcgttagagtgatacctattttttgtaaaaagaaaacaatatgctccattcttacaaagcattgattgtat
				tttaatatatacaatgtaaatactatcatgcagtggtgtccaagggagagaatacagtcatgagttcttagtttctgttattggttgggccaataaagccccttcat
				catccttcttttctgcttatcactagagacagaaactaaaaaccatggcttcaggctgctaaaagcctaaaacaaaacagaacaacaacaacaaataaggcag
				gttggacaagcttgctgagtatttgggagcctttttc
1003	2444781	—	NO	taatggggccaaaggggcaacacaaagcattgaaaacatcactggctcacaaaaacagtcaccttgttaccttctcagttgcatttgtttatttcacaaggcttc
				attcacacataaaaacaagatactaatccaattcaagttcataacgattataaaagtaaacatttgttgggacaatgtacaataaattgcactttttagacaagcat
				tacatttacatttatagagtgtactatacataatacatggaattacggaaacgtctaattggtcattg
1004	2537266	—	NO	tgatacacacttcgaaccacagccagggtccaggcctgaacagatgtcagcatcttcagggagcttttgccaggacgccgcccagccacatggccaccacg
				ttcattcaaacacggggcttcctgtcaaactacactaga
1005	3061935	—	NO	aagaggtcacccttgccgtttgatggaatgcctattatttgatagctgctgataccacgataacacagagattccctttcaattaaaagtgcctggacaccacag
				ccagacaacttctgtcccaccacatgtatactgaatttcagtcttcttacatctcatttcaaatatattttgaaatatatttccagtttatataaatagtataacacctaa
				caattcccatttatttgcaaatattattgtgaggatcgactgggacataaatg
1006	3893061	—	NO	ttcctgtccagctaaagatgctgcctggccgtggcctccacgctctgtaaacatgacccacaccccccagggcactccacggaagccttggagataaggg
				acacatcacttctatgctcacctgaagtgaccccattgttaaaggacacagctcaactcaatcagggcaccagcagcgactccaagtcagggtgcaaactct
				ggaggctgctgtgtgaggggggcactagagatggtggtaaacagaaaggggggcttccttcaccagccaggtgaccccaggcaagtcacaaggaacc
				gctctgatcca
1007	3996137	—	NO	ccatggaatcctgttggagctggtctacagaa
1008	2424640	DPYD	YES	tgggagaattgttgctatgcagtttgttcggacagagcaagatgaaactggaaaatggaatgaagatgaagatcagatggtccatctgaaagccgatgtggt
				catcagtgcctttggttcagttctgagtgatcctaaag
1009	2823618	—	NO	ttcctgctactggttggttaatgaggcactgagctaggaaccctgtaagtgttcaagtgttaaaattgtgttgttgtacctttaaatataaggagaagaaattggg
				agagatcagattaaaatattaaatacttatatggtttagaaaagtgacagcataagggagatcaaccaggtttaagggtaaatacttaggtgaccagaagatct
				acagtaaacttgaggacatatcccaccaagacccacaactcagctccagctgattgtttccacaataggactgaatgcctgc
1010	2491474	—	NO	atctggcgtggagatcgttcaaaggtgggaaactacgggaggaaggtactcaggtgttgagtgcagccatggggccacttgaattagcatccaggcagcc
				cgcgcccctccccagagacaatcagcggtgtttca
1011	3780190	—	NO	cccatgatgtctgtcgtgcagatgaatgtgtccacgcgtgctgggctagtacagaagatcg
1012	3443271	—	NO	ccacagtatggtcattcagcgaaagaagtaccaagtatttctttctgttaatgagtcagaggtattaatatatgtatgtgagtcccccatttaccctgcgcaagat
				aagttcttttaaatgcaattagaatatcctaagataaattacaaactcctcttatgtatccttttctctgaggtgaaatgagacactgcacagatgagaggtactatt
1013	3249840	—	NO	gcactgaacgctaatccctttttctatttccgcttctcacaggcacaggaacacaggcacaaatgcacaccacaca
1014	3365366	HPS5	NO	ggggctacttttgtcagtgtctgtacccttggcatcggcatctgtgactctttatccatgacctcagtgtttcttaaccaaagttgtactcagcatttcttaaccaaa
				gttgaattttgaaaagagtcagtccttgtttgctggaattagaatgttaatgtcctagtattattccgaactacagtattaactgcttgttgctagtggattagacaga
				ttcttttcttactgtggcttccatgttgggagcagaagcttttcatcctggtcacatgaagacagatggtattattgactggagagttgaattatttttatatcttgtctgg
				cacaatatggaaattactgaaataagacggtgtataatggaattaacacccaaaataagtagaacactgaagatttgaatttgatatttaagtaaaatgggactg
				ggtgcagtggctcaggcctgtaatcccaaccctttggaaggtaaagacgggaggatcacttgaggccaggagttcaagaccagcctgggcaacatagtg
				agaatgcatctctacaaaaaataaaaaaaattagctaggcatagtacctgaggccaggaggtccaggccgcaatgagatgtgttt
1015	2883453	ADAM19	NO	ctggctgtatggctgcatgtgacaagccacgtcccctcccacctctccccaaacccctgcatccctgtattcacacgggtcactctgactca
1016	2924473	—	NO	agcagggactcagcgtgaggcttgaagcaaacagtggaatctttagaagcctgctttgtgtgc
1017	3378661	—	NO	ccctgggtgtaacgaggccattttgcaactacatccagccaggctgaaaacacttactttattccgagtccatcagaattcttgaaaatcagaggatctctcaa
				gccaccccgctgaatatactctacattaaaatctgtcaccataggaaaatattagaaagataagtggtataattaaaaacgataaaaggaccataaaaaggat
				cctaagtaatacagtataaatggtgtttgttattctgtgtatatagttatgctgttagtcaataaaatatatgcttagtaagaagcatctcttagaaaatatggagagc
				acattgagaagcaacgcttgaggggttttcca
1018	3754749	DDX52	YES	aggctgggtgtcctgtaccagaatacataaaag
1019	3150460	—	NO	gctgcccacgggactttgcaggagg
1020	2664515	—	NO	ttctctttagacttaccagttaggctctaatttaggaaaaataaaacaaaaacttacatgggtttggagtaaaattagctggagtaaaatccaaggctagatttcta
				ttgaa
1021	3123616	—	NO	aggagggcccaatatccctgggtcg
1022	3432252	—	NO	agtggtcaaacccagatgagggtcccgcttctggtttatatacaataa
1023	2593632	—	NO	ggagcgggaaggagattgactgttagtttctta
1024	3054956	—	NO	tgtgccagccacagtacgatgtacctcctccaatctatgtgtccaaatcagcgcatcctttaaggccctactcagatggcacc
1025	3096135	—	NO	gggacccagaagcaaccgttatgagcaacaaaaggaagacactggtttggatggacgggaagcggttgggtgggctggactgacggaggcccctttaga
1026	3541539	—	NO	tgtgggctggccatctatatccatccatctatctattattccacccatccctccatccatccatccatttatttaattaagttatttttaacggttggctctggagttgac
				attcatttattttaaaagaacagtgaatcatagctcttttcctcaagatgcttgcttttatttgcatggtggcatattgattaagtactcagaacactatttgacatatgg
				taagccctcaataaaagtttgttattattatgactgtacttctcccctctaatgtatagaggtaaacattttggttcctattgtgacacgtgggttataatgagttagg
				gcctacttaagaagaaagtggaaagaaagcgggtaaaattgttgctcagatactagcatgtgggtgga
1027	3762591	—	YES	ggggcggtggtcattaattctgctatcttagtatctctctctgttttgctgcttgtgcacttttctatttctaccggtgtgccagctct
1028	3305557	—	NO	acctgccatcctcatagtcaccgggag
1029	2394713	TNFRSF25	NO	tggcaaaagagcaatctggatccgccttagccagatacataagggtatttgccttcactttcagccagcattccccccagcgatcctagccagatattac
1030	2406204	—	NO	ctgatatgtatctgttgggcaagtagttccatgaggagtttgtttttgttcagaatgatctttaggaaaaatggaaataccacggtgaagggaaagaagtcagaa
				tatgtacacaaagccta
1031	2722321	TBC1D19	YES	tgtttttcccgggatacatctgtgttgagtcactttgcattcaacagtgcctcgccaccaaaatcatacataa
1032	3532235	—	NO	atagtgttatatccgtgctgccatatcactaaaataggcttgccaaggcaggtgaggtgtatgaatgctcaagcctcacagaactgcaatcaagtgccaactat
				aaataatactgaaaaaagttgaccatctgaccagtggataatactttcaaggcattcaattagcttatcctttgcagtattctaagctattcacattgacgatcacat
				acattgtagtgcttgctgcaagggaggcatataaccagttgttttggctaaaatatgacaggaaggcattccttgggttctatataaaagtaacagtattcaaca
				gtctaatggcaatcactgataggctgcttaaa
1033	3053937	—	NO	tgcacgctggaatcatggctcattgcagcctccaactcctaggctcaagggatccttccacctcagcctcccgagtagctgggagtacaggtgttcgtcccc
				accatgtctggctaatttaaaaaaatgtctttgcaggatgggatcttgctatgtttcccaggctggtctcaaactcctgggctcaagtgattttcccatcttggcct
				cccaaaatactgggattatacgtataagccaccacgtctggcctgagtcatctcttttgacccagaacaaaaccagtccaggagtggctgtactccccagga
				gtgtacactggggaggcccacagctccggggtgcagtggggctcttgcaatttaatgactgattcatcttcaaaaaagcacaatctcagccaggcg
1034	3304915	—	NO	tgggagactgacctaactgagcatcaactatgccaagcactgcgcaaggtgtcgaggctataggaacgtgcctttctaccctagagaagtttgcagtctgct
				gtgggtgatgagctatatagaagaatgtactattagatggagggaagtgagggagcaacatggttacctgaggaagagcagtccaggccaagggcacag
				caagtgcaaaggccctggggtgacggtgtgtgctggctgctcatgatgcagtagggaggcctgtggctgggatgaagaatagtggagggtaaagtggaa
				agaggtgagagcagagatgtagctggcagtggggagggaatagggtgaagcagcaccatgtagggccttgcaggacattctaaggattttgactttcatc
				gagtgagatgaagattcactgaggggttctaagtagaggcagggacatgatctggcttcaatcatagaatgatggggattgactaggcaggatgggttatga
				tgtgcaaggtcgcagggggctgctagccaggtgagataggatgtgggctctggcagcagtggagggggcaaggcactgcgggtgttggacagactctg
				atgattggatgtgggcctcaagggagagtttgtgtgggagctgggaaacaactgcatcaggttgcctggggtcccactcttaggccgacaacttg
1035	3545436	—	NO	gcggtcactcagctatccaatgggatgacacacagcaaatcagctcttcactgcctcaacagacagtcactaaaataatttctttaaaggtatataaatgttggc
				cagtgtaatcctctacaaaacacatttgcaaatataaaataatggaggtatgatgctgctcagagaatgggaatgctctggcagtccccaacatcctatcccac
				ttggggctttgctccgaggggaagagcaggtgcaggatatattgccctttgatgtgatgtagatgctactagggacccactgggaagagtcccgttccttga
				gttatgctactgtagggatagacccttggtgtgaggaatctaacaatgagtcaaaggaaacatcacaaagaaggtgacacctcagaggagacaaaggact
				ctgaaatcctggaatcacgggatatctctgattggttagggaattcctctgcactcaatctccagcaaatgggcagattccctcacaacttagaatttttcatggg
				gagtgctggactgtaccccaaacatggagtaaggtggcatcatccatctctgaagggccatactcctcgcaaagc
1036	2632506	NSUN3	YES	tgaatatgatagtctgagattgaggtggctaaggcagacgttggaatctttcatcccacagcctttgataaatgtaattaaagtgtctgaattggatggcaga
1037	3333132	—	NO	cctgagttcctgggcactctttcctgagcttgcttggggctgatttgaattcag
1038	3459329	—	NO	ctctggattttgccactcacacagttg
1039	3597530	APH1B	YES	gccagtgaaggtttgaagagtataaacccaggtgagacagcaccctctatgcgactgctggcctatg
1040	2757682	—	NO	aacagtgcaagaaaggacgcatcactctcttctggtgccgatgtgctctcttgttaa
1041	2811303	—	NO	tcacgtggctttgtgtaccaggcgtccagggagcaattaggagggcaatctgttaagtcttttgcctcagggcagaaccattaggtgtgctgtgtatgtgcctc
				aaggggtgtaaataactaagctattcatgtactcatcagtttcctttcaaggcatctgtgaaacctttaatctgtggaagaatcagagaaagttgacctattgtatt
				attatcctccctcacctgaatattttga
1042	3611032	TTC23	NO	gagtccttttgtcctgcggtccatataagagggtctggatctggagacactgtagaacaccaagcagctatcatgaggctatggaagtgtcgctgagagcag
				gaaactaaggtctcccttgaatgagagaaagatgacctcattcttaggccctgctgtgatggaattagcatgctcctgggatgtctcctagtgactgacctttgg
				tttggatgttctgagggatctaggcaaaagtgaacagttttagcactatttcacaaaactctctgtgactatctgtatgcaaaaaatagatttaaaagtagtattttt
				aaaaataaaggcaagaaccttggtactgaccagaggatgggctccagtttctatttttaaatgtggcccttgttatagcctggaaaagatttaaaaaaatagtttt
				gttttttttgtaaacacatactctacttttattaatatataggctgtctatactcttgactacacagcaatgtcttagttattaggaaccaaatattcagcttatggacta
				cccagggctggctttggcttgatttctcccttctgcttactttaagtcttgccatttgattgcttgtagtaggctagggcaaatcaaggagaggagaaagattaaa
				gttgtgcccaaaatggccaaaataattttgagaaagaatgaggtggagaggtggaggaacttgctttactgaatgccaaagacccttttatttttttaaataaagt
				aattaagacagcatgtttgtcacccggggtagacaaaaagaccagtggaacagggcagagagcccaagccttgacagatgacagaaatggccttgcggg
				attggtgaggaagaggtgggctagtcaataaatgggtactgggaccgctggttttccaaatggaagaaaatggatcactaccccaaatcaaacacaaatatt
				aagctcaagaaagatttgaaggactaagtgtgaaatgcaaaacttggagcttttagatgaaaatactggaaaatatata
1043	3977071	—	NO	gtggctggaccatgcggaactggat
1044	3363301	DKK3	YES	tgatggaggacacgcagcacaaattgcgcagcgcggtggaaga
1045	3644748	—	NO	tgggccacgtggtgctctctgaagttagaa
1046	3799937	—	NO	catgcagtccccaaggctatcggtcctcctcag
1047	3336773	FBXL11	YES	gaggagcttgccaacagcgatcccaagttagccctcactggagttcctatagtacagtggccaa
1048	2822962	—	NO	tgtgagaacagactcggcagtgacatccactccaaatgga
1049	3627325	—	NO	ccagacctgagccacgtagctatcaaacac
1050	3780263	—	NO	catctgaaattaatgggactaatgtaaggattgatattttcatatttgctcaattgcatcctgggttaagcacattcaacag
1051	2656010	VPS8	YES	atggcgctatctctgccctcagtatc
1052	3028587	—	NO	tcacccaggattctcctgtacctgctcccaatctgtgttcctaaaagtgattctcactctgcttctcatctcctacttacatga
1053	2419066	ZZZ3	YES	gttgcctttgagtgatggtccagaag
1054	3081481	—	NO	atggccacctgtgttgacgtggaga
1055	3935290	—	NO	atgatgaaagcgtggaggtaccagct
1056	3051677	ECOP	NO	ttgatgtgtgaacgctgacctgtcctgtgtgctaagagctatgcagcttagctgaggcgcctagattactagatgtgctgtatcacggggaatgaggtggggg
				tgcttattttttaatgaactaatcagagcctcttgagaaattgttactcattgaactggagcatcaagacatctcatggaagtggatacggagtgatttggtgtcca
				tgcttttcactctgaggacatttaatcggagaacctcctggggaattttgtgggagacacttgggaacaaaacagacaccctgggaatgcagttgcaagcac
				agatgctgccaccagtgtctctgaccaccctggtgtgactgctgactgccagcgtggtacctcccatgctgcaggcctccatctaaatgagacaacaaagca
				caatgttcactgtttacaaccaagacaactgcgtgggtccaaacactcctcttcctccaggtcatttgttttgcatttttaatgtactttattttttgtaatgaaaaagca
				cactaagctgcccctggaatcgggtgcagctgaataggcacccaaaagtccgtgactaaatttcgtttgtctttttgatagcaaattatgttaagagacagtgat
				ggctagggctcaacaattttgtattcccatgtttgtgtgagacagagtttgttttcccttgaacttggttagaattgtgctactgtgaacgctgatcctg
1057	2699603	—	NO	aaagaaggatctgtcagccaagtcttttct
1058	2836754	—	NO	agtgtggccgtttgcattactgctggaattttgaagactactacatattccgtcagtgtcaggattttgttcttcagtgtggtacttttttttttttttttttaagatggagt
				ctcactctgtcgcctgggttggagtgcagtggtgtgatcttggctcactgcaacctccagctcccgggttcaagcgattctcctgcctcagcctcctgagtagc
				tgggattacaggcatgcgccaccacacctggcttatttttgtatttttagtagagacggggtttcactatgttggtcaggctgttcttgaactcctgacctcgtgat
				ccgcccacctcagcctcccaaagtgttgggattacaggcgtgagccaccgcacccggtagtgtggtacactcttaaaatcatagttcctgctgtctg
1059	3504560	—	NO	gcatggccatggatcgggcaagttggttttact
1060	3924596	PCNT	YES	agacctgaaggcacaatcacaagaagagatcaggcgcttgtggtcccagcttgattctgccaggaccagtagacaggaatt
1061	2408919	—	NO	taggtgacggattgttaggtgcagtaaacc
1062	3219942	PTPN3	NO	ggaccaggcttctaccattaattcacatgctttaaaaaaattaaaaattaaaaaaatgaaaaataaaaaaacttaaaagattttacctatattcctggaacatagtt
				atcttaccccagctttgtagttcctgtttaaggaaattccctctgaaggaaattttagctctcaagagtcaaagaagatgtatagaggtggtatctgttagtttttgtt
				tgtttgttaaggatctaggcagagaggtcattacatttttctgaagttgaggtcacaggtggggtacccacaagagaggtcattacatttctgaagttaggcatc
				ccaggcatctcttctaaagaactatcctgtattctaattgttaaataaatatcttcttcattgtgagcctccacaactgctgtttctgataaatttagatcattctttgca
				gaattttatatactggcaatctcaaaactaggctccttcaagattcctaggaagtctcccaagctcgggttgggttccactattctag
1063	3240958	DNM1P17	NO	gtcaacaagaccttgctggacctcgtg
1064	2830809	—	NO	gtgcagattgttaatccctagtgtgcagggatagggagggagaggaaatgtccacacagacgaggagaaggcctgtaaatgcaaatttcacactgttgatg
				gtttgtcctgttggttgaccagcattcccaagataaccaggtgag
1065	3020549	—	NO	cctcatgcatgcttcgagatcattgtttgcttcatttccctaaaatctacagttcctttgaaagtagactctggcgttatcacctttccccggtctttttgcagtttcctg
				ttgacctctgagccattctccctcactcttgtttcactctgtttgcaacactacctcttcctgtatcctggcctctcatttctcacagatcatcatgctgttcttgaaac
				attttatttacttgattttagaaaactatactcttagtttccctaaaatctcataatctctttgcgggattttcctcatctttgtgacttccaaaatttgaagtgtcccctgg
				ccagtcctgggtggctacattcaatctc
1066	3282482	—	NO	aaaagaagtcgtttattggtgcatgggacactctgggaggtagtatccatttggatgtcctgctgcggttggagacatggaacaaaa
1067	3192070	—	NO	cctgtcggtggactgaatgggccaagtgttcagaagtccttgggaagaggatagtgtcctgaatcataatgtggtattttc
1068	2473609	—	NO	aaagtgtcctattctcggggtggcagggaggggggcaggccacaaaggacatgagtgttaggaaaagaagaaagcacagggaattaaggcaggaagg
				gataggctaactactgttctgtgcaaatgcaattgggtttatgatcaggactgactgcccttacgtataaagttgctaacccccaagacctgaagggaaaagtc
				ttttgaagctgccagttttttgatcattcaacaagaagacctgaacactgagaatcctttttctggattggttccatcaatactttgtccctgaaatcaggaaatacc
				ttgccattatgggacagccctttaaagttcttttgatgttggacagtgcccctggccacccagaaccccatgagtttaacaccgaaaacattgaagtggtctact
				tgcccccgaacacagtctctaattcagcatctagatcaggggatcatgaggacctttaaggttaataacacacggtactctaacctcaatagaacatcatgaa
				aatctggaggaattacaccgctgaagatg
1069	2814779	—	NO	actctgctgactgtaatggctctcacgcagttcctaatgggcactgtggaaccactcagcatagacaggcataggcagg
1070	3558342	—	NO	gcccagtgaaggggtgacagaactagcc
1071	3611698	LRRK1	YES	atctcctgccagatcacggagctcgacctttctgccaactgcctggcgaccctcccctcggttatcccctggggcctcatcaatctccggaagctgaacctct
				ccgacaaccacctgggggagctgcctggcgtgcagtcatcggacgaaatcatctgttcc
1072	3701429	—	NO	tgccgcttttccctccacttgtgtaacagcatactcaggtttataccaactgggagacacgcaggcatctcccctcacaagcagctgtctactcaattctgtagtt
				atgtctgctaagtaatcagaatgcacaataggtttttagcatctgtatctcatcctcagagtagagagtacctgttttacgagagaaaactgagaaaacggtctct
				cagggcctctggggcagccttcaattggacagcagtagaatttcggtccagttttcaaatcttttcttattgttggattgactatgccatcctgcaaaaggaaaat
				tactttaaattattatttcaaaaaaacaacacaacaggctggagtggaaacggaatgactgaaaacgagcacattttgtgaaatacttttaattaagagtttttcca
				tctagtgtcagcagtaagagaaaaagagtatgagtagattaaacgaaatgtggtgagaatactaagcaagactctaaaattctgcattcatttgaccattactg
				aattcctcttagtcaatttacattccagggagatgccccccttgtatgttcctaggctgtgaaatgctcca
1073	3933333	C2CD2	YES	ttccgccggcggcatcaacagaaagacccaggcatgagtcagtcacacaatgaccttgtgttcctggagcagccagagggttcccggaggaaaggcatca
1074	3799749	—	NO	ttggattccactaatcacccgatcacccc
1075	2487131	ANTXR1	YES	gaaagctgcactccaggtcagcatgaacgatggcctctcttttatctccagttctgtcatcatcacca
1076	3187719	—	NO	gggcaaacttcagcctcattagatagaggctggacttccggaagagctgggaagggggaccatagtttctggggaggggtggagaactcacatttaccta
				gctgctggccaggctattttcatacccacagaccgatttaattctcaactactgtactcatttagtagatgagaagaatgagacattgaaaacatgcacagtgga
				ggtgggaatgaaagccagctctccaactctccagtcctctttcctgtcactgcatcaggctgcagggtgaaggggaggtctgggatacaaagagaacttag
				aggtggagcagttggattctgtgcagtgctaggagggaggagaggggttggagtaggtgggaagtaggcctccttcagtttggatagcacttcccttaacc
				caatgactctagtgggagggtggagggatggggatgggaagggagcctgggagtgaggaggaaaggcaaactctgtcttcccccaggggagtcaatg
				aatagtacc
1077	3474744	—	NO	ttagtgtacccttcggtgacaggtaagggctttctgaaacgcattgtctttttattatagccattctagtagtaaggtgtgaagtggtatctcatagtggtttgggtt
				gtatttccctgatattgggatgttg
1078	2489696	—	NO	atgcagttacaaaatcggattcagcatcagaacag
1079	3195395	ARRDC1	NO	gtgagtcgacagccagggcttggca
1080	3497381	—	NO	ggtggacagtgatggtttcaaaggggaaa
1081	3130174	GSR	YES	tcattgttggtgcaggttacattgctgtggagatggcagggatcctgtcagccctgggttctaagacatcactgatgatacggcatgataa
1082	3180421	—	NO	gagaggtggatctgtctggacttcaggctgtgagaacctcacagcacagataggatgtgagctttaccccttgtgttcaggccgctcgcacggagtcagctt
				gcggaagcacgttcccaggcctgctctgcgtgtaatggtggaatt
1083	2384882	GALNT2	YES	gaagtcggtgaagcacatggatttgtgccttactgtggtggaccgggcaccgggctctcttataaagctgcagggctgccgagaaaatg
1084	2601621	—	NO	tctcctgcttcctagacgaaatctaagcaatattttatccacttctttttagtaaaagaaatacatattgcctgttggggtcatgagctatgtagggaatgaaaaaat
				tttttaaaggagaattataaagagaaggaggatacaagagaaaggaaaacgaaagctggtgggaagttgagccatgtttatctctagtggaatccttaccttg
				tgttt
1085	2624206	ITIH3	NO	tggatggcccggattttatggcatctggaac
1086	2626149	RPP14	YES	tcaagattgtggagttggactgaatgctgcacagttcaaacagctgcttatttcggctgtgaaggacct
1087	3466862	—	NO	tgtcacttagtctactgccagtctactgtctgtgccaccatgggaaattgcatgagttcagacctgtgaaaaatcagaataaagataaaaacacattttttgaag
				gttacggaaattcttaagatcttggttttcttgaacttactactagtactactgatttagaaatggcctacctcctatagtaggaaagggcaaagaaaacaatagtt
				aatagggaaggcttaaaggagcttgagggctgtcctggcaataatagaagagatccttgttttttaaaggagagttaatgtacaaagattctgaaaagtctaga
				aacatgggtaaaatttttatgattgccgggcgcgg
1088	3400762	—	NO	tcaatgaccagcgtagacagagctagtagcagcaatgagatgagtgactagagaggtagagagaaaaccaggaaagtgtggagtcatggaagctaagg
				aagatggtgttgggaatagaggtggtgaacagagtcccctgttcttgctgataggagaggtcaaatgagataaggacagaggcgtggcctttggattccga
				gatgtgttgatcaccggtgcacttggcaagcatgcca
1089	3511392	KIAA0564	YES	aatcccgcttccctgtactttatgaatatgactgggaaaagtggcttctttgtggacttttttgatatcttcccaagaacagccaatggcgtttggcacccttttgtg
				acagtggcaccgctgggaagtcctctcaaaggtcaagtggttctccatgagcagca
1090	3762555	—	NO	tgcacatgtggtaagagcatccagcaggaaagaagagggcaagttgagtgtgcgtgggcatgaaggattcactgtacgcatcccagccctgctcatctca
				gccgcatggactgggcacacatttaagcatggagggtggtggttttcaggctgttttctagagctgtagaactcaaatgaaatgctctgagtctgtgaggggg
				ggaggagtcaataaagggtggctaagtgcatggagtttgaggtacccgctctgctgtaacc
1091	3853067	ILVBL	YES	gcttgctgctctcacgggagaacgaggatcaggtggtcaaggt
1092	4015570	—	NO	ttcatggttgcctagtgctgcgaggagtggggaatggggaatgagtgcttaatgggtatgggtttcttggggtgatgaaatgttccggcactaagttgtggtaa
				tgactgcatgactttgtactaaaactactaaattgtacactttaaatgggtgaattgtatggcatatgagttatt
1093	2458440	—	NO	tgcacttttgcctccgaactctcgtgtttaatta
1094	3333734	SLC3A2	YES	atgggttccaggttcgggacatagagaatctgaag
1095	3379257	—	NO	ggccgtgcagcttcttgacaaattgcaaaggtgcccacgagtttccaagt
1096	3662461	NLRC5	YES	ctcaacttgatcacgaggttcctgacaccgtccgagctcctttttgatct
1097	3670791	—	NO	gtgcaggtctaatgggctccttccttc
1098	2689662	—	NO	ctcatggcaacttcttccgcttcctagtttca
1099	2698749	XRN1	YES	gctgggatcactatggaagcaactatgcattgggggca
1100	3940626	—	NO	tgcaggctttacctatgaccgaacatgcatggaaatgccctctgatggactcaggcatgatacatacatcaaacagccttgcacggtggta
1101	2577438	—	NO	gagagcatggctacaacagcaatatttctggaaaccagttatcgggggaattcacagg
1102	2885881	—	NO	atggactcatcccagaacaatcctcaggcactccgaaatgcagatgccc
1103	3473848	TAOK3	YES	atggctccagaggtgatcttagctatggatgaaggacagtatgatgggaaagttgatatttggtcacttggcatcac
1104	3721713	—	NO	agaacctggtcgtgtcttgagaacccagtccaaacagaatcaggcctctggactgggagcaacactcccttcacccgcaaagattcaggaaaagcacccc
				aaggacaaggaaaccaatgaggtctgggctagctctgcagctttaggatactagctctagggaaggattttttcctttttaaacagcgtatcactctgttgccta
				ggatggagcacagaggcaccctcatagctcactgcagcctcaaactcctgggctctggcgatcctcccgcctcagcctcccaagtagctgagaccacagg
				cacgtgccaccatgctcctagggaaggagcttgagaagaaactgccaggagtgaaccagggctggctgctctgtgatgttctctccccacctcccctccag
				ctctcaacttggtggcagggccggcaccctgctctccctcctaactcccagcctgctgctgcccccttctgggaccctaattttctggactttgagaaatgggc
				tgcccctgggggtgcctccaagagcccatttgagggatcgggtggggctgacctctctgtcttctttggatcatcgccttctcacactgtcctccctcttgattct
				gaaaaatggtcctgctgcccatggagaaccacagtaagatagatttctcatgcagctagtgaggggacttc
1105	2924660	—	NO	accatgtttttgcctccagtctgtc
1106	3242466	—	NO	atggctatgggaatatcgggagttgaggaagaaaaaggctccagtggcactgaag
1107	3268238	BTBD16	YES	agcagctcaccaccggctgcgagaagtggctggaaatgaacttggttcctctaggggggacgcagatccacctccacaaaatcccacaggacctgctcc
				acaaagtgctg
1108	3293847	SPOCK2	NO	tgtggcatgcgctgacaaatgtgtccttgatccacactgctcctggcagagtgagtcacccaaaggccccttcggcctccttgtagctgttttctttccttttgttg
				ttggttttaaaatacattcacacacaaatacaaattgacaggtcaaaatcca
1109	2416565	JAK1	NO	aatcttgctttttgtggcctggggattggctgtgtgatcagcattgaaatgggttgttgcagtttgaagtctggaaggggtatgtccctgggttctaattctttccct
				ctaggtttctgtactcagctcagagtctagaatggtagcttttaggattggaaaagaccaaagttacctaattcaactctttcatttttttttcagtggaaaaactaat
				acccagaaaagggaagagagttaacccaaaaattacatctagtgaattgtctgattagctttacaattgaggcattgtagagctctttgaggcattagtcttggtt
				gtctgagtgcctggctattaaaggctgtctttgcctgttccctctttctgttagctgcctggaagtgcagggttgcttcacttttagcaccttgactctgtacctgac
				atggtgcttcaacaggatattgc
1110	3198506	—	NO	gtctacgcagctgccatagaggagggggattgtttgggagaccttcccgtggcagaatcaaagctcgtagttcagctgcgggaatctggtgtacttaa
1111	3384336	RAB30	YES	gggaagacgtgcctcgtccgaagattcactcag
1112	3649726	—	NO	ttgtgcaacagaaaactcaacccaa
1113	2732288	—	NO	aggtttagttgtgtggccgtaatcacatccaacaccaagtcggccaaccatatgtgagcttaatcccacagaattcttatgttagacctccctcttcagataatag
				aggagattttttttaagtatacgtgcacagaggaagtgacttctttctgcgcactctgttgtcactggaa
1114	3291868	—	NO	tacgaggaagtgaccagtgttcatctgaaacggatgccttgtttctcagaaatgtcattctctttatttcatcttcgtagttctgtgccttctctcagcaatttctgattt
				ctttatttactgccacacagatgacaaatgacatgcatgtccatgataccctttactcaattcacatgcgatttccaaggctggctataattcccaaa
1115	3572359	—	NO	gtggggggctgtaatctacaaaagccatcttcagtaccaggtttaattccatcattgtttttcgggttttaggtctctggactattgtcctttaacaacaaca
1116	3613987	—	NO	gcctgcctgttcatgccaaatatacatcctcacaatgcacagtacacaacatgggcacataggcacagaggctatgccgg
1117	3768275	—	NO	ggctttgaagggcaactgaccaacttttttatacataaaggatataaactacaactattttcccactctgtgtagaatgtggaacggaaacagtgtgtggcacac
				tttaaatgatgctaaacttctacagtgtgtaaactggcttgttcaagaggccaaagtgcttctgttgagaaacactgatgaccaatctcctctttgtggtcctgtga
				tactgtgaaatatatatttgatcttcctccctgtttcccagcatacaattcctaaaaccctcagaatctgcaaaataagatttttttttaatgctaatgattgactgatg
				gctggaggctcctagagagcctcaggattggggctgattctcagggctttc
1118	2367980	RABGAP1L	YES	gaccatcttctccaggtggactacctgaagaagatagtgttttatttaataaactgacctacttaggatgtatgaaggtttcttccccacgtaatgaagtagaggc
				tttacgggcaatggcaaccatg
1119	3063344	ZNF394	YES	gtgtgaagaatgcgagaagagcttc
1120	3147137	—	NO	tttaggaaaaggctgctatactgtggacgaagtctcagatcagaa
1121	3737089	CCDC40	NO	acgggacgctttctctgggatgcattgagtcagggaatagaagatggggtgaatgatgtttctgacccacagaccgttgggatgcttttgctgtcactttccca
				tcatgctgcatgaggcatgacagcagctgt
1122	2686311	FILIP1L	YES	tgccaagcatgcgatattcagagtctccccagaccggcagtcatcatggcagtttcagcgttcaaacagcaatagctcaagtgtgataactactgaggataat
				aaaatccacattcacttaggaagtccttacatgcaagctgtagccagccctgtgagacctgccagcccttcagcaccactgcaggataaccgaactcaagg
				cttaattaacggggcact
1123	3307401	—	NO	gccactctgctcaaagttggcacgagttggaatgtaatcaccatctctgcactcaaggcatgcagaaatgaagtctacctcagccctcaaagacctcacctg
				agaaaaagacaaggctccaaacagaaggcaaaacagaatgagcatagaaagagaccactttttcacatacctttacaaagcactgctcacccctccttaac
				ctcgcacagacagagcatggggcctcagtgtcactgccactgccaccctcccactgactagctgtactctctga
1124	3648042	CIITA	NO	ctctgaggacactaaccacgctggaccttgaactgggtacttgtggacacagctcttctccaggctgtatcccatgagcctcagcatcctggcacccggccc
				ctgctggttcagggttggcccctgcccggctgcggaatgaaccacatcttgctctgctgacagacacaggcccggctccaggctcctttagcgcccagttg
				ggtggatgcctggtggcagctgcggtccacccaggagccccgaggccttctctgaaggacattgcggacagccacggccaggccagagggagtgaca
				gaggcagccccattctgcctgcccaggcccctgccaccctggggagaaagtacttctttttttttatttttagacagagtctcactgttgcccaggctggcgtgc
				agtggtgcgatctgggttcactgcaacctccgcctcttgggttcaagcgattcttctgcttcagcctcccgagtagctgggactacaggcacccaccatcatgt
				ctggctaatttttcatttttagtagagacagggttttgccatgttggccaggctggtctcaaactcttgacctcaggtgatccacccacctcagcctcccaaagtg
				ctgggattacaagcgtgagccactgcaccgggccacagagaaagtacttctccaccctgctctccgaccagacaccttgacagggcacaccgggcactc
				agaagacactgatgggcaacccccagcctgctaattccccagattgcaacaggctgggcttcagtggcagctgcttttgtctatgggactcaatgcactgac
				attgttggccaaagccaaagctaggcctggccagatgcaccagcccttagcagggaaacagctaatgggacactaatggggcggtgagaggggaacag
				actggaagcacagcttcatttcctgtgtcttttttcactacattataaatgtctctttaatgtcacaggcaggtccagggtttgagttcataccctgttaccattttggg
1125	2568862	—	NO	tcttcttctagcagtgctcagtgggt
1126	3405549	DDX47	NO	tggcgtgagcgagataaacctcctaacagtaggtttgtacaataaggccatagggcaccgatgcctgtttccataattgttgtaattttatgggctttgaagtgtt
				gctctagatacttactttctcctttcagggtagcgagaggctcccattagaatatttcatatgtacctgtctggtttgcaagctgttgagttgatttattcagccctag
				tggtaataatgactc
1127	3479324	ANKLE2	YES	aactgaaggagcggatcagagagtattta
1128	3736140	—	NO	tggatgtctactttgcacgctgcgattgggagagctgtcccgctgcatgcgttccctctgtaatttcctcagagctcacatacgtacctctctcacgagtgaact
				cagattttccattgttttgctttattctatcatttgctttgtggttttgctgtaaatattgaaatcttaatcatcatcgagaggcacagccaagctttccagctctccacc
				cccgtggcccatccaagtctgttcatctggtaacttctgttgtctgggacggcagcaagaagatgccggggcttgcctggagtcctggcagaggagtgcca
				ctcacttttgcctagggtccagttggggcttaaaaaatatttggagagaagagtaatgaggattttttgtgtttcctagacattttatgcatctatttttgtaaaatcac
				cttcgctaactttcaccaagcactttgagcacagtggaacttcagaagcacaaccagcctaaccccagaatctcaggtggcacagctagaaattgagtccctt
				cctaggacactggccgtggccttcagggtgaccagtcagtgccaccgggttggcattggtgttacagacaggcctctgaagacaaaccgagcaccccag
				cggcccctcaaactaagcaaggatcttttttctgtctgcgctccctggggcaaggtcaaaggtggacccgcccactgtgggtcaattcatcgaaaagatgg
				gacccgcacccccgccacaggctggcccccccccacccatggggaaggtggtgtgctgctggctctgaccatactcttttggaaattgagaaggaaagca
				ttgagtgggacctaatccggagaagaaattaaagaccagaaaaagaaggaagctgggaatgaaactcaaaatgcacttgaacctggaagcggcaaccct
				cagctctgcgcggccgagcctcagcaagagttcgttt
1129	3954953	—	NO	catggtctaaccacagaggggaatactactcagcaatacaaaggagtctctcctaatacgtgcaacaacattcatgaatcccaaaaactttatctggagccaa
				gccagacacaaatgtgtacatacagtacggaatgacttcagattctgaaaaaaggcaaatctgaccaattgaggcagaaagcaggtcagtggttccccagg
				tctgggactggggtgggttactgatagcaaatgggcatgtgggtgccttggggtagggtaaaggttccatcttgatcacggtggtgtttcccaagtgtata
1130	2396759	FBXO2	NO	tcgagggtagataggccttaacttagtccatagcgtcctcaccttccccaagccacacatcctcctcccatcccttgctccgatcccagcccctgagcaggga
				gagagaagttttgttggcataggtttgcttaggtagccggcttctagaatgtagatccgtgagggcgtgagcttggactggacccactgctgattccctgcac
				ctagcacagtgcttgccacaaagtgggctctca
1131	2519281	ITGAV	YES	ggtgagcgggaccatctcatcactaagcgggatcttgccctcagtgaaggagatattcacacttt
1132	3640619	—	NO	tctgttgtctcgcccttgctctgctcctacttcacccatcttctgagatccaagtcaaaatcatctgcacg
1133	3976861	HDAC6	YES	acctaatcgtgggactgcaagggatg
1134	4048293	—	NO	ggggtagaacaatcaagcttattcctaaggattttcttttgacaaataaatgggtggtagtgttgtttattgagataggaaaaactatgggaggaaatgatttgaa
				gtgggtggtttgaaataaaagttttgtttaaatatgagatgattgattgacatttatgtggagaaatccgaaggtcaatggcatttaagagactcatggtgaggcc
				agggcttcaggtatttatgttggcagcagcaatacgtgtagtgtgttaaattccagggcgtg
1135	2393657	KIAA0495	NO	ccctgtttgtctgagccctttggagatttaggttgagtcatgagaaccggtcattggaacatacactttattatgttacaaaaacaaaaatccccactgaaacaca
				gctaaaaaaataacacattttcccaagattacattaccaaaaacagttgttatgtcattggagggcgtccattaatactgctcggagaagcacgatcttaca
1136	3389355	CASP1	NO	aggtttttggaattatgtctgctga
1137	3584178	—	NO	attgtagtttgaagagctgcccttgggaactcatgggacaggcatcaggcctggaatgggatggacaagtggggcctccaggagaaggagcattgcagg
				agatgctggagagtggggagcagtacgtgcagcagatagggga
1138	2365984	MPZL1	YES	tcaccagttaagcaggctcctcggaagtccccctccgacactgagggtcttgtaaagagt
1139	2468456	—	NO	aaagcaatcttaacagtgagggctatgaaaccgttgaaaattctcccaagggaagtgatggaaacctccttgcttgagtcatttcaaagtcgacaaaacaacg
				aaaaatacatggagggagggatcctgtagtgttggggagcagactcgatgatttcatagttcttttctgtctctgatttccatgttctgtgaaatagtattgcagct
				aagaaacatgaaatccttcactccgacagtatg
1140	2954656	YIPF3	YES	acctgcttcggctactggctgggagtctcatccttcatttacttccttgcctacctgtgcaacgcccagatcaccatgctg
1141	3499189	ITGBL1	YES	agatggcatattgtgctcggggaagg
1142	3102170	PREX2	YES	gaaggatattattacagagacaatgtttctgtggaagaatttcaagctcagataaatgcagcctcactggaaaaggtcaaacagtacaaccagaagctc
1143	3151372	—	NO	caggcactgtatcaggtgctgcgtacttctgctagctcatctcacctggtcatgccgctctga
1144	3153640	—	NO	ttcttccttgatgcaggatctgaggttgaag
1145	3708351	—	NO	tcacattctggggttagaaggggcccaatggatgggaattcttcatataaaagaggaaatgcc
1146	3793991	—	NO	tgcaacaatgggagctttttaactagtctctgtaaggcgttgtcatcacatctg
1147	2840186	DOCK2	YES	catgagttcatgagtgacaccaacctctcggagcatgcggccatccccctcaaggcgtctgtcctctctcaaatga
1148	2945913	CMAH	NO	ttgcctcccggagtgtgtaaccacatgagaaatagagggaaggttctgtccttaagaagttaaaagtgtgactgggaaggtaaaacatacttattaagggtta
				actagcatcatgccattctgtgtgatggtgagtttgtgtgtgtgtgcacatgtgcgtgagtacacacatatacatttaaaaaggtcttgaatataccaaaatattat
				gtctaggtgatgggtagcttgtatattttttctgtatccttgtctgtgtttgtcaaattttatagaaacaataacagtaacagctctctgaccttctaccctgtatgttct
				gcgtcctgtctaattcctcaagttccttcactgcctgtcactctgatgcttgctatatatcagcccatcctgctttttgtttcttagacccaaagtgtcaagtgcacac
				ctgccctgggtctttgtgtttgctgtttccatttcctggagtgcagctggccctgatttgcatgtgaccagca
1149	3706405	PAFAH1B1	YES	tcgtcactggcagcgtagatcaaaca
1150	3898481	—	NO	atggcggcagagtatctggttctctt
1151	3962245	NAGA	YES	tgctcttgctgggacatgtggcccaggtgctgatgctggacaatgggctcctgcagacaccacccatgggctggctggcctgggaacgcttccgctgcaa
				cattaactgtgat
1152	2877309	BRD8	YES	cacagagccatggtccatccgagagaagctatgttt
1153	2973720	—	NO	gtttggtgtctggtacttagagctccctgaaactgtggtgttt
1154	3091762	FZD3	YES	aatcatttgcctctcggccacattgtttacttttttaacttttttgattgatgtcacaagattccgttatcctgaaaggcctatta
1155	3418179	—	NO	ctgagctcatccagtaaaactctcaaaagatgaatagatgcccttttccttgaggagccttctgcctgatttctttgtcactgagtttgggtccctggttggagtgg
				caggaggaaggggtccaccacgtcttctgac
1156	2685385	—	NO	tttggtgtctttctgaagggattcggcccggag
1157	2912792	—	NO	ggatgaaatcgtgcacgtccctcttcgtccctctcaggacagaaattcttttgtccagcatatatctatgttgcatataccaccagccaattagtcacttagtagct
				ggtgttggttatgagatcaactgtcatagtatcacagtgcttgtttcaggtaacccttatgttatttaatagtggcccaagagtgcaagagtactgttgctgacaat
				ttggattcacgagaagc
1158	3590727	JMJD7	YES	tctggtatgacatggaatacgacctcaa
		///
		JMJD7-
		PLA2G4B
1159	2363028	—	NO	gaaacgccgtcctgcggaaacatccaccatccggacc
1160	2374733	—	NO	tagagactggatcatagaaggagttgtttgccatgcttacccttaaaggctttctgagcagtcatcctgggatggacagggcagggagtggagagaccagc
				gagcaggtttttgttacggttcgagtgagggttgaacacaggcagtggtggtggagatgggttgcagggataatcttgagagagatttaggagacaagattc
				acaggttg
1161	2448301	TPR	YES	gagattcagcgattgcaggaggacact
1162	2596900	—	NO	gaatggtgggaaatgtatgcttgactcaaaacagccag
1163	2713805	ZNF595	YES	ctatatgttctcctttcagccaagacct
1164	3878694	—	NO	ggggtgtctgcgtggggagaaatcagttgtcggcattttaaatctctggataatgag
1165	2434634	ARNT	NO	cggctgttgatacgattgtctgttatcgaacacattcagtgataaagctgggttactgctgcttttggtgctctcaccttatctggaagatctgcaaacattaccta
				aataggctggcaagataaacactttctggaacccgagacttggccataaagataatgctgcatttttctgtcagaatcacatatgatgtgtgttctgtagaggtta
				tttctgcatggaaactcaacttcttggattagccgtcccagtgaaaatcctcattgttggagtgtaaaccaaatacgaagccctcttgcaaagtagcctctttcat
				cccatactcaaaatacccagtttagcaagcaactgagatttaagtctctctggccctaagaggtttttcctctttgctccctccaatcttgagattgggttttgcttta
				gagtgcaagtatcataattccgtatgatagatggggcctggacacccatctcaacagggtcacttggtaattaacaatagccatataaatgcggatacaggtt
				actaccctcaccctttaccttcctcaggtaacagtcgtagataccagcttttttttttttttttttaaattggctttggccagtagctaaagtgcaagactgaattaatg
				agaagatatattaaatgtagtcataggggactgaggagcaagggtggccttgaagaggccaaaggaatgtccatttgctgagtttcccttccttatgtctccag
				tctggtgccaggtagtggagtaaaaaaggagacagtttatttttttattctatgtgcacacttacagtatacatatatatttatatcacaatttacgaaaccaaaaag
				ttgagtttccaatggaacccttgttttttaataatcgactttttaaatgtgatcaggactataatattgtacagttattatagggcttttggggaaggggaggatagc
				gagaagatgctctgggggttttgtttttgcttttccttcagggttttatttttgactgttttg
1166	2502158	—	NO	tgcactttcccagcgtttctgtctgc
1167	2511348	—	NO	agacaacagtaaagaaataccagcaatttgaagccctgtccctgaatcctactcctgttgccttcatatcgagagttccaagtgttggcctgcagttaagttctga
1168	2697262	DZIP1L	YES	ggaactgcatgaagagcacatggctga
1169	3829727	GPI	NO	gttctctgccaagtgctggccagaggcgcgtgtgttggtcctggtcccccgctttctcccccactgtcctgtccctcccctccccgtgcagctgctcag
1170	2566885	—	NO	cctacgaggtccatggcagcgggtacttgaaggattta
1171	2644609	—	NO	ggctttgaggatctctgtgccactttg
1172	2681773	FOXP1	NO	tccttacgaggctagagattttctgacaacagtatgttagtttcatttggtccgtgaatggagatggcagcaaatattctcagaccctcccagatctggctaaga
				catccccttatttaggaacgaccctcccctggcataccctactctccatcgcctgttggcaataaacgtgccttgtggatattccttaaaagccttcctgccatcc
				ctctagcagtcactgtaaagttcaaatctcaaagatgcttaggagccaagattctctctgctcgtgcccagcagcccctgctgtgagctcactgccttccccag
				cacgacctcctaggctgctgccttcctttctgttggagtctggagtcaggctaactcctaaaaatctgcagagaggtctctggagggaggacccaagcctgtt
				actacctaagccagaattttacacctagtttccttgaatagagaagtccaaccccagaggtgtgcacacacacccgccctgcaaatcagtgacggggagaa
				agcctgacttttcttgggttttgctagtgggggaaattgctcatttggaagggcaccagcaagctta
1173	2941811	—	NO	gtgtcgcttttattctaactgctggaactatttgttgtacctctttctgaagatcagtttggggctaaattacaagctccatcagcacaggggccatggctgcctcc
				tgactgctgtaggctgagcacttggtagagcatcagccc
1174	3037970	—	NO	tcacctaaaaggacgaatccatctgcttctgtctctggtactgagggctttttagattccggaggctttctgaaga
1175	3235439	SEC61A2	NO	acactttgacggatcgtttttgtcagatga
1176	3670576	—	NO	ccaaggtcacacaatacgaggtggggtcagaatgcaaacccaggcagtgtgcctacctagcccagactcttaaccactaagatgtcactaaagaagca
1177	2682104	—	NO	ggagatttggagtacttggagcatggag
1178	3809910	—	NO	gggaccttgtccctctttgcatggagggatggtttctttaggtcctgggggatagcccaggccacttccactctgaagatctgtgttctttatcagtctttcaatct
				agtatatttgcatttaataggtgacaaatgggcctggaagctgtggtgggg atggagtgggaaaccagctctcagtctgacattgactcctggaggggagg
				gtcacctctgttcctgggcagcctttcagtggcgaaggccaccatcccccacagcgtgattgagaagcctggcacttctgcaatgagtactgtggagcctga
				cctttggctagtagcttggtctttattgacagggctgtc
1179	2428310	—	NO	cccgggtctgtcataaccgcaaatttctataccactctgctgctttaagatatcaacaggcaaaagataaccactgtccaactcacataaaaataggacatcaa
				gttttgggggacttcatgtcctacctccagcttactaagcctgctatctctggagattccactactgcaaacctagttaggcaatgggtaatagcattacccatta
				agccaaatgtggagtgaacaataataataatcactaggacttggagagtcactaaataaagatttgttgagtaagtggaggaaggctgccttctaagctgtgt
				atcactttggccccaacctgcagtactccttcccactgtagccactgactcctgctcccagcttcaaaggctaggatcctctcataaagaattaccaaagccag
				agatccctacctgcctaatatatactgatgcctcatgtgggcccttga
1180	2429289	—	NO	tgtggtttgattagtaactaccctggagtgtctcaacttt
1181	3246430	—	NO	acccgatgttgacagtttctccctccctctctctctctgctgtttcctctatagagctaagtctggtttgcattgaaataagcatgcagtaatatgccttttgccttac
				caacttgtatttgcacacaggcagca
1182	3314235	—	NO	gtgtcctaagcgggtgcatgtccag
1183	2332841	ERMAP	YES	tggagaagagcccggttgcattttg
1184	2452077	PIK3C2B	YES	catggtgatgcatattcggggcttg
1185	2592323	—	NO	atagagggttcttgcagctgtccaaggtagaggcagtggaagcttgcgctcagtagaatcagtggaggtaggaagaggtggacagattcaggttatgcttt
				ggatgtgataccaatatagaaggatccttatgttgaaggattagatgcaggagtgagagcagaaagtcaaggatggctctacagcagctactagaacccctt
				gaaaaatggtaatgctgtacacggagctgggaaggcaaggagggggcaggggcaggagttttgtaggactcaataggtttgtggagagaaaaggaggc
				tgatgggaaaatcaagggctttgttttgagcaacatcaagatacctattaaatattcaaggcatcaaacagtaaatgagtcagagttgtactagtatcaagatttt
				tgatcattgttttattaatcctaatacaaaccttcctagttgtcagggttcagc
1186	2895598	—	NO	atgttctcggaacaaggaaccagtaaagtacagacatctggccccaggattttgctggctccagggacgtcactataaacccactaacactaattgctttcac
				gtctgctcccatttcta
1187	3578431	—	NO	catgcgaaagcaacagtctgatctccaggttatgaaaactataattaaaaagtcactacacagaaaaggtccaagtttccagcttggcaaaacttgggtgcag
				ttacatgaaacgtttaataaactgaattgttttccccaatgtgtaaacaaaatgacaagactaaatctgtgcctggtaatttcaatctaactctgaagctacacaaa
				acacacagacaccttgtacatttcacctgttagtatgaccatcttttttcttcggtggtggaaggaagggcaaggtgactgtgtaaagcaaagatgtgggaagt
				agaaatattgtttactagacattataaagtcatggtgaaaagaaagcttcgattaatgcatagcctaaggg
1188	3590373	—	NO	tcttgtggttccttaacttgtggcagcataactccagtcttcacatgaagttcttcctgtgtgtgtatctgagtcctaatataaggagactagtcatattggattggg
				gtccatcctgctctgttaatgacctcatcttagctgctgacatctgtaatgactctattaccaaataaggtcacagtatgaggtagtaggggctaggacttttaac
				atacgaatattgggaggacacagttc
1189	3277334	—	NO	tgcctgcttcacacaagtcgaactgcaactgggatcttggcttcttgtcaagtcagtagcatgcaagccagtttaagtcaaaagaggacacactcctcttactt
				gattccccttgccatctattttctccctcaatcttagccacttggagaagaatttaataccttttttttttccagagtccaaaggctgtggatctaagtggggcattttg
				tgctcaagcgaatctgccatgcactacggtttcaactc
1190	2323027	—	NO	gagcggtatcttgaaggtggctttaagtttgggaagttcgggaagagcagtaaaggcacgatactgggactgagcccagtaggagt
1191	2360843	HCN3	NO	tgtcagcagatgtcttgggtcctgagt
1192	2834307	STK32A	YES	gaataaacaaaagtgcgtggagcgcaatgaag
1193	2890310	C5orf45	YES	aagaagaaaacgtgggacaccagcaggc
1194	2510000	—	NO	gataatgaagccaacgcaaaaatccacgtctccaggctaa
1195	2575065	—	NO	tctttccagctcatgtctcccggggggctgggctgtctcctgtcctgcagccgcagcacttgatctcagcaggtggaatgcagagcagaggaatccgccag
				acattacagggatctatctgagtataaaacgggactgctctttccactaaattgcttttggagaataaagttaagtgaattaaaatttccccagtctcaattgctaat
				atggtaaatattcgcagttacaactctcattaacaaaatctcttaggagtcctcagtaatttgagactgtaaagacgtcttgatactacaatgcctgagaacgagt
				tctctggatcttacctgcccctcttacatgaggaggcaccctgatgtctgggtggcttaccctttggcctctggcgggcattcagcatgagtgaa
1196	3336723	FBXL11	YES	tttaatgtagagtatattcagcggggtggcttgagagatcctctgattttcaagaattctgatggactcggaataaa
1197	3660063	—	NO	catgctctgacgctctatgccactgctgcacct
1198	4029263	—	NO	taaaagactgaacaagaagggcacagtgttcacggagattgaagtgaacaagaaa
1199	2663789	CHCHD4	NO	gatgaagatttggacccttccattcataatccctttctaagtgaagggagaggctggcttggctgttccttgttattccgaaagccctggtttggggcccatgttc
				acactggctctcagtctagtcaggtgca
1200	3743045	—	NO	gccactctcgtgctgcttgagctgc
1201	2826559	—	NO	agcaaagactctcgggaacaccctattacaggaaaatctctcatacctgacctctgcttaacccactcgtgagattaaatgatagtcttcattctctctgtagaat
				ttgctgactgatgctcatgctacattgaatgacagtagactattctttagttttatcttgaacttttattccccccagttactgtagacttaccaagaaacatttgtgttt
				gtacccaacacactgttatggcacttgatgttgtaatcacatagtttaatgaattattattcagtgaactctgaagataaaaaggcgtttgtatgagaaccaattgg
				ctactttgaaatcaagtgagtagccaaaatcaattatggttgaaatagatgagggttaaataattttaaatgattagggaaaaaaaaacaaaaaacacctaacg
				atctaaaaaaatctgcaataatattatttttcacgtttgtaaaatgtctttctgtgtttaagaaacagaaactggaaatcacaggtgttgttttatgggggtagtttttg
				caagaaaaaggaaatagaactttcttcgatagacccacactgga
1202	2882611	FAM114A2	YES	gtgagccagccaagaattctgagtctgttgaccaaggtgccaaaccagagagtaaatcagaacctgtagtttccactcggaa
1203	3044784	—	NO	gacccacggcaattttgaatacttggaagagcagtctaagtaccctcacacaa
1204	4016017	ZMAT1	NO	tgtaggtattcccatggtttcatccttgaccttactctacaaacacgatttctatttccctgatttcatttctcatctgtatgcttatgacctttctgtcaagtattagattc
				acatatccaaatggcagctactgcttcacctggatgcctcatagcca
1205	2872559	—	NO	ttggtgatgctttatcgacctctgagaatccctttgtgatctgcagtgctactgtggttcacaaaatctgtgttcttgctctccctgatagcatctgacatttgtcatc
				aggggttggcaatc
1206	2810393	MAP3K1	YES	tgctagtgcaactactgctccatcgatcccttcacatttgtctcctggtttacgagatgtggcttcgttgtttagaacttc
1207	3309863	—	NO	aagtgtagcggcaggcatcctggga
1208	3349873	NNMT	NO	gaatgctgttagcctgagactcaggaagacaacttctgcagggtcactccctggcttctggaggaaagagaaggagggcagtgctccagtggtacagaag
				tg
1209	3849058	—	NO	gtacatcattacccggcacagacaca
1210	2609601	—	NO	cccctcaaatcttacagctgctcactc
1211	3489275	—	NO	tctcttgattagtctaggtggtggtttagttctgttctgattttttatttgttttagagatggcatcttgcgatgttgcctaagctggactcaaactcctgggctcaagt
				gatcctcccacgtcagcctcccaagtacctgggactgtaggtgtgcaccactgcacctggctgtctgctctgatctgcaccactgcacctggctgtctgctct
				gatctttattatttcttccactaattttggatttggtttgttcttgcttttgtagttcttgagatgtgcattgctagattgtttatt
1212	3490771	—	NO	tctccgtattgcttagggtggtctcgaacttctgacctcaagcagtccttcggccttggcttcctgaagtgctagagttacaggcgtgagccacagcacctggc
				ctacatattacatttaagtctgtgatgcttttagaatttttatgtcaagtgtgagatttaacttgaggttcctttttgtggggtggatagtatgttcgggtgttctggcac
				ctatcttttctcattgaattgatttgcacctttcttaaaaatcagttgagcgtatttgtgtgagtctatttctaagttccccactgtgttagattgagctgtatgtgatcta
				tatgtatgttcctctgtcagtcccactgtcttaagctgtagctgtttaagtctgaaattgggcagactcattcctcctacttta
1213	2353513	—	NO	taatgtcatcatcagtgggcaagtctagaaccctaatatcctggtgctcaaaattagtgttatcaattcagtcttctccacattaaacaatttccaattcctttgagg
				cctggtgtgatggattctgtctttcaaatgctttttttctttcagtgactctatcgttcataaatgttaaataaaaccctcactctgttataaaaatatagactttaaaaat
				tttccaaagtaaacactccagagaaaggtaggcgggctgaataggctgctgttgtccttcttactgccca
1214	2610157	CRELD1	YES	catctgtgtgaaggagcagatccca
1215	3092298	LEPROTL1	YES	tggggagcttgtgcacttgttctcacaggaaacacagtcatctttgcaactatactaggctttttcttggtctttggaagcaatgacgacttcagctggcagcagt
1216	3241630	CCDC7	YES	taaagaaaatcgaccagaagcagtgaaaagttg
1217	3489976	—	NO	ctctgaggtttaggcctcgatattcaggagagtggtgtaggaggaagatgaaccactgggttttagacacatggaggcttagttcagggctttgggcctccc
				ggttagtttgtttagtcttgttgatctaggaggagatcacaccagatga
1218	3671050	PLCG2	NO	ggagaacgtgccctattcacactctgggaagacgctaatctgtgacatctttctttctcaagcctgccatcaaggacatttcttaagacccaactggcatgagttg
				gggtaatttcc
1219	2476149	—	NO	gtcagttagacagagtccacaagggagtcg
1220	2670672	—	NO	gaactcacggtcttcagccttcctgc
1221	2792848	—	NO	tggccatggtgaaacagtgcctcta
1222	3168127	—	NO	ttccaatcagcagtatcatggattaaat
1223	3227785	—	NO	gggcagtttgactatgtcgcatccagcttcccatgccgtccatccctaggagtctgtctcaccatacaagggcgcagacaggccagcttgagggtgttcatc
				aacgcagcattgtttgaagagcagaagttagaatctattcattcgggggcctgactgcataaatacactgtggttgccgtccagca
1224	3367153	—	NO	cttgtatgaccctttgtctcggttgactagttgtttgctctaagaatatttcatgttttgctgtttctttcagtttgtaggtgctaagctattgaaaggtttagagactaat
				ctaggtctttctaaattatggctgcttgcagttttattcctggagaaatggtttaacagcacttctttgagttggcactcttctgcctgtctcagctctaactttcccgc
				ctccttttcagtagtccctctttcaccctccactccccaagcctgaaatggaaagaacttgctttgttactgatgataatatttaagctctaaaattttaacagtgttt
				cagttgcaaataaatggaaattgtgtattctgtttaatgtgtttcagaaaatccctgctattttttttttctttaaatacaagaaaacaggcgtgtaatgcctcattgaa
				aa
1225	3483227	—	NO	tttagtcaagtaggttgagagcaccagggatcattttttcttcacaaccttttagctcagtgatacccagagcaatgtgcctactcagtggagaagatagtatttgtgt
				gaataaatttactgttctgtgtgttacatgtctagttaggagtggtcctctaattctgta
1226	3766878	POLG2	YES	aaaatgtggttccttgtgttctctctgtaaatggggacctagaccgaggcatgctggcctacctctatgattctaccagctg
1227	2555150	—	NO	tgggcgtgaataaggaagcaaaactcaattataataacattactattgttcaaacttcacatggcacttgcaaccggaggctactttgtctgcctgtctccatact
				catgctgtcttatgctcatgttcttca
1228	2601747	DOCK10	YES	gataccacttcccactcgtcttccaaggggggtggaggagcgggaggaactggtgttttcaagtccggctggctctacaaggggaattttaacagcaccgt
				gaaca
1229	2664745	—	NO	ttatccaccgcacatgaaagagagctcagcgccaactgccagtccactgaagggtgtcgcagtgatatttgtttga
1230	2698409	—	NO	atgtgctactaacaggtcaggagcccagatcaaagagctggtttgggaggtggataatgaaggttgtgaagtctgtgctccctctgagaagcctgaggaaa
				atgcaggtggctccctcaatcaacagacatccaaaatgg
1231	2704917	PHC3	YES	atcagcagattcctcttcattcaccaccttccaaagtttcccatcatcagctgatattacaacag
1232	2823922	CAMK4	YES	aaatgggattgtccatcgtgatctcaaaccagagaatc
1233	3717013	—	NO	ggtctatatgtctgtacttatgctggtaccac
1234	3498270	—	NO	atgtccagcgcaaggacactgtccagccttctcttcctgcacatcagctgcctcccgtcagtcctgctgaacggggatccttcccagatttc
1235	3737381	—	NO	cttcaaagggtgtccagatgctatgaagcattgggttcgacttggggtccacgtggtttgtgcctcagggtccaaaaccacctgcattctaccggtggcgtct
				gcagaagacgaatggcttgaaggagctggcactccgccggctagatgatccaaaccatttcatttctttgtcgtgtggaaaaggccctctgtgatgcacttct
				gttctctgga
1236	2512319	LOC643072	NO	ctgtagctttgagtttgcaccgttccttgtcccaggaaaaagttaagaaacttaaaatgttttgttttgctttaaagaagacaggacagaaaacgggatttaaaa
				cttagtttttaaaaaaacaaaagctacagagtagggagcataggtcaaccatctccacctaaattttttttgttcctaaactcagaattctacaacccaactaaatt
				aatatgccaagattttgcggatgttaaaactcaaaaaaagcagtatgcaagacggtcccggggtaaaattctactgcctttccacggacaagtta
1237	3596425	—	NO	agtcctcgctgtagcatggggtaaagccaggatatgacttcacatagtttaactccagaacttacactgtcatcttgttttgtttttctgttctcttgtgtgtcaaaa
				gaattcctccttagttgttctcatatggggcaaccattaaattaggcagtgtaaaaaacaagttatgcagaataaagtagcaagagcaatctactctgaaattag
				tgttttccctcactttagcacctttagctgacccagcttcctaccgcccagactttttacaaaatctctctctggagttgcctcctgatctggattaggagtcacata
1238	3809494	—	NO	ctgtgtttaacacggctgtgctacttcaggctcccatctcgctgagggtgcccatgtcagccaatgacctt
1239	2442446	—	NO	gtcttttgcagtaggtcagggctaagaggactaatccctcaagagtgaagaaaaaaactattgatggtggcttgaaagagtcaactgctgtagcttttcttgga
				gatgatcacaaaatggggagcagaaaacaggttgaaattacagaagattaattagtaagaaaagatgggttaaagatgtaaattagaggcaaagttaagaa
				gaatttggtttcttcattatactcagaaaggtaaggatggaaaagttgatggagcaagattgtgaagtatcttatatgcaagactaagaagtttggactagattct
				gaagacttaggagaaccagtgaagaaatcttaatagaggaatcggattagatcttagggtcagaacaattattagcaagcagggtaggtgaagttcctgttg
				acccactttg
1240	3281111	—	NO	agcatctgtcgctggtgagaccctcaggaagcttcactcatgaggaaggcagtagggagctggcatggcttggcgagaggcaaggaaggagagggga
				aggctcttttccataagcagttctccctatggcaccaagccatttatgagggacccacccccatgacccagtcacctcccaccgagcaccacctccaacattg
				gggatcacattgcaacatgaggtttagaggggacaaatattcaaactgtatcactgggagatggggctaccggaagtcaagccattcc
1241	3770080	—	NO	ctgtactaagtgctgatgtgccagcgctatg
1242	3821078	—	NO	acagatgtgatcaaaaggcctaatatatgtgtaattggagtcccaggagtgaagagtgaaaatgaggcagaaaaaaattcaagtgagaatggctaagaattt
				ccccaaactgatgaaaggcatccacccacaaatcccaattttgtacttccaaccactgttataccacccccctcaacaatgcctataaatgtttgttgaaaatga
				gtgaatgaatgtactccaatcattttctcacttggatgttccctactttttgc
1243	2531265	SP140	YES	ataatagcaaagccgacggccaggtggtctccagtgaaaagaaggcgaacgtgaatctgaaagacctt
1244	2719554	CC2D2A	YES	actggtggctcgatatgtgtccttgattcccttcttgcctgacactgtctcatttggtggtatctgt
1245	3342924	—	NO	tgaggtccacaaatcagtcaagttgaataaagaggaaattctaaggaaaatattaaaaattacagaaagaggaagctggggacactgagcataaactttgat
				gacatcaattttaccgtgtgcctatccactattcctccacttagtttctcagatcttgccagcaaccttagggcttgcatcctccatttc
1246	3811421	—	NO	gtacgtgtgagtgcgctgtataaagtctggaaccacaattag
1247	2448106	—	NO	ttgtgtgattgcaatgctgaatttgtc
1248	2661177	—	NO	ccttgttcccacatcggcacattatc
1249	2748212	—	NO	aggcattttttgtccacacacttgctttggggatttttattaggtagacggtaattagaggtgtcagtcatatgaaagtaaatcactagtctttcgtattactgttttct
				cagtggtccttatcagttttttttgttgctctgtaatcattcatatggtaagacttaacttttagtcatgtaaatttgtttagggacaatttaaactattttgtcaaattagtc
				gttttattccaagttgtacgtcttatgcatttatttagtatagtgaaagccttatatacacatttaatataattagtctctggatatttggattattttttagtagtactttttta
				gagtgtgggttttttcttttcttttctgtttttgagacagtgtctggttctgtcacccaggctggagttcggtagcccagtctt
1250	3081649	—	NO	cacctttgtgcatgtatatacttcaagttgtatgaatttctttatgcaaagagcctttaaaatataaactgtgatttttgtttctaattttttactttggattgacagggcct
				tttttcaagtgttggaatttccttttagatttcttatcagagtttatcttgattttactgaaattcatttagctatatgaaattcctttagccatagtcttgattcagatcccc
				ccacctgagtctttccaggaccttgtgccatctgttattgccattgttgtattcacttacagcctcttctccatgagtacaagcccaccatcatgctc
1251	3415065	—	NO	gagccattcctttggcaactcttgctgtcagccatcttccaaagagctttg
1252	3436225	—	NO	tgtctaccatgttgggcagcacagatctaaagcatttagaaccatggctagagctatgtgtttactatcattgcttcaatatggagagtcatccaaacaggtttca
				tttgctcccagataaactgtcatgggacctgccgtggccagtgctcaccttgtactgctggaataatttaacaatttttttcaactgccatcatcatcatgccatttt
				atgtcttcgtagcatttatcactatctaaaggtaggtcgctta
1253	2546677	—	NO	ctcccaaactcttgaggacatgtggggaactacagctgg
1254	2723423	—	NO	aaggtagtgtgcaaagcgaaaagagggcacagaccaaaatcatgcaaaa
1255	3291647	—	NO	gtgggttacatgttcctgcctggca
1256	3449366	IPO8	YES	ggacctcaaccggatcatccaggcgctgaagggcaccatcgacccgaagttgcggattgcagccgagaacgagctcaaccag
1257	2935290	—	NO	gttttacaacacccaaagcaacagaaa
1258	3296065	KCNMA1	YES	gttatggtgatctgttctgcaaagctctgaaaacatataatatgctttgttttggaatttaccggctgagagatgctcac
1259	3414403	SMARCD1	YES	tacggtgtactgtcctactgatgctggattacca
1260	3611215	—	NO	ctagtctagggatagtggtagaagtacgtaatgtagatg
1261	2997513	—	NO	cctttgctctctcatatgcatccggcacagcagc
1262	3180413	—	NO	ttcaagggcataggcgtcggaattgtgatttcgtgcgtgttt
1263	3732510	—	NO	gaaccactttgttgaccttctgctgcaa
1264	2572597	CCDC93	NO	ctggacggtgtctatcaaaagtgcaaatgcataagctctttgaactagcaatgctactcctaagaattgtacctgtgtacaaggtacttgtgtacaagagtttttgt
				tgaaacattgtaatagcaaaaagttggagagtgccaccaatacaggggaatggttaaatacattatggccagcttaaacaatggaatagtttgtagaaatttaa
				aacaatggatcctgtgtgtgtgtactaccatagaatgggccccaagatgcatgattaagtgaggaaaaaagcccatggtatcctaatgtttggaatggagaaa
				gtgtgtagatgtatgtgtgtgcatatgttttcacacagacgtatacacgtgtatatcatatgtccacctgcatatgcctaggatgtctctgggaggatatctagca
				gcccggcagcctgaattgcctctgggaa
1265	3216409	—	NO	aggttctgaagtcccaggcaaatgtaatagggggtaggcagaggacttacttagagagatggtggtgaaagtctcaaactgcagatttctagaacaaacag
				gttacttgtaagaagcagacagagatacttagatcagtaaaatacttctgtaacactagaagtgagaagacatgagaacgttatctagaaactatcaagagga
				aatgactgcagaccaaaaatcctacgc
1266	3294290	—	NO	tccacagctcgatttggccaatttcgagttgaaaggatggtactggacccaggcctcataagtagcttgtcatcaagatctctagtagccaaatcagaaaccc
				acaatgaagtaaagatcagtatgtcaaggaagacaagactaacggggtaaaaagccttagactagaaactacatttagggggaaataaagcaaaaataaa
				aacctttcaataagtaacactagtttccagatggtactctagctcaggcatgagaatctgttcttaaaagtgggacattatttcaatcataaacataatttactaga
				atggacatttggcaaagcaagtccattatccacctgccatcacagtcacttttttagtcaccagtgaaggcaagcctgaaggacacctactccaaagtgcttcc
				caaaaatttgccacaggggctgattcctactctgtttgaggcattcttttgtgctgaaagattgtcaccagaaagacaactgaaagacaaatattgctgcttggg
				agcagttgtggcaccagtgtggctcccactgtagcaattaaag
1267	3446505	—	NO	gtcttgtagcactcaaacctttgtctttcccacaagactgaaaactccatgacacaggaatatttcttatcctgtgaacctttgtgtcataccacctatagtagtgttt
				agtataaaataaattaattgtttggaaatctatcctaaaaaaaaaaacctagattcagtaaaagctctgtggccaaggatgtttgtgttacagtgaacaccttcga
				gcacttcagg
1268	3616936	—	NO	ctcatagcatggtggtctcgcagtagttagccttcttacatagttactggcttt
1269	3628351	MGC15885	NO	cctccgttacccgtcagcccagcatccggctttgcttccataa
1270	2745112	—	NO	gcaaaattggtctggtatctgtctaaattggtcaatacaagtgttattctggaatcatgtaaaaatcacttactttcataactgtttagaaccccaaatgttttcccttt
				gaaggggaacatctgtggaatatgattttgaatagaggacttctatgaaatatatttcaaatcttaaaaatatttttaatacttcctaaagtggtataggatttaccct
				cgctgactatgccttccatttaagaacagtcttgcatttgtggcttttca
1271	2824232	APC	YES	tgtccctccgttcttatggaagccgggaaggatctgtatcaagccgttctggagagtgcagtcctgttcctatgggttc
1272	3101817	SGK3	YES	agttctggtttcagtgggaagaagtg
1273	3129414	—	NO	cctagctgtctgtcaggtagaatgagggtgaaggagatctaggatgcttcaggcattgcgcttgaacttaaaaaacaggatcagcaggccctgacttcataa
				ggcccataaatacaaatgactagctccctttctcaaggtcattgaaaatatacagtagtttcagacatcacatgggtttgggcaaagggggcagatttccaagc
				taggtcacttaatggtatc
1274	3576514	—	YES	gtggccgggaggcaaaacttctctatgagtggaaacgtttgaagaatacatcacccattacgattttgctaatcttaggtttcagacaccacagacacattgatt
				ctatttggaaagatagccatcaatcagccagc
1275	3650814	COQ7	YES	ataaagaaatttcgggatgaagagcttgagcaccatgacataggcctcgaccatgatgcagaattg
1276	3723777	—	NO	gccaaagagcatgtagagcaaactaggctctattcagcatttccatttcttaatgtatctatttgatttcaataaaatttcatcattttgaagatctctcccattagctt
				gggaaactacagaaacatgcacataactactgagaaggtatcaagtgttcctacactagtttaaaaaaatcattcaacacccacataaattctgatatgcacta
				ggctgaacagctgttaaccactgagaagctgggcactgcatcctctccctgggtcaaaactctatatgct
1277	2550931	—	NO	atgcacatgggacagtctaagatggtagtggtgg
1278	2681842	—	NO	accaagtgacattttgcattcagcctt
1279	2868846	—	NO	gctctagtgccacaggaagctgcct
1280	2880139	PPP2R2B	NO	agccaagggagaacccaagacagagaa
1281	3309073	—	NO	attgaatgattgtttagaggcagtgtga
1282	3636536	HDGFRP3	YES	gcaattcagcaacagagctcttcagaa
1283	2347802	RWDD3	NO	gggatacattcaggtctcagttgttgaggctgttgagcagcaatccaggtatgaaaatgggaaagatttgactgcttctctcatgcaggggaataaagcaaag
				gc
1284	3202177	PLAA	YES	tcctgcacttgacattcttcggttgtcaattaaacaccccagtgtgaatgagaacttctgcaatgaaaaggaaggggctcagttcagcagtcatcttatcaatctt
				ctgaaccctaaaggaaagccagcaaaccagctgcttgctctcaggactttttgcaattgttttgttggccaggcaggacaaaaactcatgatgtcccagaggg
				aatcactgatgtcccatgcaatagaactga
1285	3945822	—	NO	aaggaagcgagagacttggcagtcctgtaggctttaatggaatcagcaatggacgctcg
1286	2682207	—	NO	ggggctttaattcttaatcgctgtgaggattgttatccgtgggatgtgagctgtcttagtggtattcaatcaagtgtccacttagccatgactggaagtaattgctc
				ccaagtgggcc
1287	3263773	DUSP5	NO	agccattacgggagcacagcatgtgctgactactgtacttccagacccctgccctcttgggactgcccagtccttgcacctcagagttcgccttttcatttcaa
				gcataaggcaataaatacctgcagcaacgtgggagaaagaagttgctggaccaggagaaaaggcagttatgaagccaattcattttgaaggaagcacaat
				ttccaccttattttttgaactttggcagtttcaatgtctgtctctgttgcttcggggcataagctgatcaccgtctagttgggaaagtaaccctacagggtttgtagg
				gacatgatcagcatcctgatttgaaccctgaaatgttgtgtagacaccctcttgggtccaatgaggtagttggttgaagtagcaagatgttggcttttctggatttt
				ttttgccatgggttcttcactgaccttggactttggcatgattcttagtcatacttgaacttgtctcattccacctcttctcagagcaactcttcctttgggaaaagagt
				tcttcagatcatagaccaaaaaagtcataccttcgaggtggtagcagtagattccaggaggagaagggtacttgctaggtatcctgggtcagtggcggtgca
				aactggtttcctcagctgcctgtccttctgtgtgcttatgtctcttgtgacaattgttttcctccctgcccctggaggttgtcttcaagctgtggacttctgggatttgc
				agattttgcaacgtggtactact
1288	3497166	—	NO	cgccagcataccagctcatgtttcagaatttctgtcacaaaaaggaacacaatattttaagttgactactgtgggaaagctatgatcattcaataacctacctttct
				gatagctctttctcagataatataagctataaaccaaaatagtcagccttcacctgatttacagtgccctttgaaacttcctaagttttctagcccagtaaatgctga
				gctaccagttctacttccaagctagagaacctgtttactaaagttagaagtctagtgacttcctctgtcagactgtcccagaatgctctccctacccccaacaact
				gtgtaagaaccgtcattagccatctccaaattgccaaagtgctcagtcccttcg
1289	3618874	—	NO	gtaacatgcatctgtgtgggaacct
1290	3202840	—	NO	tttcactgctactgcgaactggtcctgaaggtgcagatctcttagaaggaggactcccacttcttggtggtggtcctctttttactggatgtggtcccctggaag
				aactcatgttaaaattcatggaatatccaccgtcatccatgtgtcctccccgtgagggaggtccccttgttcctccacttcctcctcttccacctctaagacctctt
				ggagggcctctacttcttggaggtggaggcggtccacgtctaccactttcaaatgatggtttgttggcttgttccacctcgatggcttttccatctaatgactttcc
				attcatgtctctggctgcatccttagcatctgctgggctttcaaaggtgacaaaagcaaatcctcctgatttgttggtttcatggtctttcaccaagagtacttccac
				tattcgtccatatttgccaaatactgcttcaagagctttctcatttgtttccgtgttaagcccaccagtgaacggctttcctgggcaatctgc
1291	3755656	—	NO	cattaggggaccctgcctgaatctttgccaacctgcaaggaaactc
1292	2469949	—	NO	tgccagtgacatccagggttattcgtatacctcatgctttagattcgcttctggttcatggtgccagcccttagaaactctgggttcctacctgaagccggtcttat
				caaaacgccacccctggttccagtttgatcagggtaaccttgtgaattagcaagcagcagtccccagtgtgtgctgacatggaggttggagagaaaatagat
				atgtcccatgcctggtttccagccaatactgatgtcgcgggttagtccagcaggctgaggctgaggcctgtgacaaagtccctgcatggaggtcttcctgcgt
				cagagcctagccctgttcaata
1293	2830605	—	NO	gagctttctaatgggggtgggaaga
1294	3235906	—	NO	ttggggttgatacccatcatcgctcttagactcggggttgatactcgtcatcgctgttacactcagggccgatacctgtcatca
1295	3616555	—	NO	aggcagacatcaaccctctaagacatttttttcctatcctctgggaatattactttttggacaatcttggtccattggtaagctcatgggaatttgtcagagtttttttg
				tttcttttggctcatgtttagcatcgattggcagagtgtttggagtcatcc
1296	3369121	ELF5	YES	caggaattttggagcgggttgaccg
1297	3908978	—	NO	tcccatcagcaacatccgtcataccctgacgccc
1298	2338495	—	NO	aagagcaggggacctatgatgcagaaagtcctttgctggagctcacaggtcgaatttcagggaagctgcccaagggcttgaacatccctgctttcaggttcc
				ag
1299	2452931	—	NO	ccacatagtacggtgtataacaaggagtggtcaaagagttgtggctggtggtttccttggcaaagccaaagtcagtgagtttcaggatggcgttgggcctttt
				ggaggtgtataagagattctc
1300	3448040	—	NO	tgttaagccttcctgagatcacaccaaatgtccttgatgggaattgtaaacaacccttacttctggtttctaatgatattccaggaaaggagcctaactagagtca
1301	2823916	CAMK4	YES	gattgtggaaaagggatattacagtgagcgaga
1302	3799998	—	NO	gggcatcaagaatttggacatactggtgtctggtatcgaggttcttcagctactcaatgcacgtgatgatggtgatgatcatgatggtaacaacagac
1303	2978095	SHPRH	YES	tcatgaatattggatggctctgaggaatcgtgtgtctgctgttgatgaacttgcaatggctacagaacgactaagagtgcgtgatcctagggagccaaagcct
				aatccgcctgttcttcatatc
1304	3475634	—	NO	gacacctcaggtgacatgctttatagttggcctgagccttgacccagtggttcaacctgagtttggtcttggtaccattcaggtgtttgtgagctgagactgatg
				agtaggaacaggtgttttatatctcgtcttttgtcaaaagtaaagactcattcctttggtaacccaaccaaatcaggatcag
1305	3683092	SMG1	YES	gtattctgagcacacccaactacag
1306	4022048	RAP2C	NO	cgccaagtctctgggctattttttatttttgcaaatgtgctttctaatagccattgccaccatgttgtttacctaatcagcatatttttgtctgaatacttgaacattttaa
				cagtaacgcaggtgtagaatcagaaaggaaacttatgcagagtaatattttggttcagttttaacatcgtgacaatgagggctttttctagcaatgatttttaaatt
				gtgtaagtttgacagtattttattgttgggtttttatttgattttagttgtgtgcttttcatttgcagaagttagtaactgcagctcacctactgcaccaaagttctcgattt
				taggagcccagctttagtcatttgaacatgcttctaaataaaataaaacaaaaccaaaactatacttttgatctataataagagctcaataactttgtcaaggaaa
				gctctaatatatgcagtgatggtttatgaaagggtgtggcaattttaaatttatattgtgtgtgatgttcaaataaagtggtatctacattcatgtgatttatgggtca
				gcatgaccattaattactgagtagaaattgactaaactttgatttcctttttttaaatcgtgttgcatttgattcctgagcaaattccctcaaagtgaactcttgttctta
				aattttgaattttatggtgagattgtaaagatagaggcaattgaaacattgttccttatttatgaactgcttgaagtgaatacttaatttaagtttgcactttaatacca
				aacttaaaaccaaacactcatttaaaagtaggttaagtgatcatggatcattgttattagctttgtggctttgtgaaattctaaaggaatcaaataattcatcatgatt
				taaattttctagagattttgatttttttataatgtttctttcctgtagattgtgttcttgtttctctctctctctctctctctctctctct
				ctctctctctctctctctctctctctcaaaattacagtgttcattgtcattgacc
1307	3153356	—	NO	ttttctgaggaatagggctcaatggtgggcttagaatattgagtacaccatgctgtaaacagatatgctgtcatctaggctttgttgtaccatttagagagcacag
				gca
1308	3529618	PSME1	YES	gtggatgtgtttcgtgaagacctctgt
1309	3830025	—	NO	aattcattcgcctccggtacttgcaagcctcgctcagtcttaagcaagaggggatggattcgcccgcagcactgagaatccaggggcaggcgggatggcg
				ttcaggcgctgttgctagaaatctctgtctttactctgttttgaaggcagcatggcagggtgaacacaagcacagactgaaggcagcttgccgcggttcacat
				cctggtcacaccacttcctgaccatgtcacgtgggcaaatta
1310	3866580	KPTN	NO	agggatgatcccattccaccctgtccactctggatgagaattggccacctgatggttatttatacgtccagaagaac
1311	2620390	TGM4	NO	gccacctgctgacgacccttgagaagctgccatatcttcaggccatgggttcaccagccctgaaggcacctgtcaactggagtgctctctcagcactgggat
				gggcctgatagaagtgcattctcctcctattgcctccattctcctctctctatccctgaaatccaggaagtccctctcctggtgctccaagcagtttgaagcccaa
				tctgcaaggacatttctcaagggcca
1312	2693884	—	NO	cagtctgagttcctgcacccttcag
1313	2724817	—	NO	gatgatgctggacaaactgcaaatcctgaacttagagactgttgcagcaataaccattttgactgtgataatatcattctgctcaagttg
1314	3718581	SLFN5	YES	ccagtgacccggaaaaccttcatgaaaaacaactttgaacacatccagcacattatcattgatgacgctcagaatttc
1315	2645299	—	NO	ctggcagcctgctcaacactttaaattttatcagtttagtacctgctgatgcgtctaaaactgttggtcccattctagttttatacttacatatgtagtattaaaagcac
				ttaagagaaatgtagaatatataatctttataaaagtattaaaggaattatttaaattgaatttgtatcccatttatcttgcttgctaaatagatttaattggagcatcca
				tttgtataacgtctggctatttctacaatgttaaaacagtgggttgaggaagtaaaatttgagttactcagttactgacatagaaaagaaccctgtgagaccaaat
				tcagctttggaaacaatttagtgtaattattttgcatatgtagatacacctttgaaagccaagaaaggtttatgattggatctgtactatattaatttaaaaacaaatta
				ttcttaagtatattgtagcatttctgttcctgtaagtactttactcatcttaaatgtactgatcattagccacctttataaaaagaatgtgcctgacccactagtatttga
				tagaaatattaaaacagttaagatccttaaacatttctgcatataattttttattgagtaaatgtaacttaacgtaagtagttctatgaagtctgtgtaaattaaaaccc
				tgttttgtgtagatgaagcaatctttataagtttctgtcatcaagactgtattttgtgtgctatttttccatagctaggaaggtggcaagtaaaacatatgcactatcct
				agaaacatactgttccaggtagatcttaatttactacctggaatgagccatcttaggtgaccacca
1316	2927067	—	NO	aatctgtagttgtaatgtagccttctacctaaataaaagagatcctaacataatggttctcattacttaagcctcattatgatcaagctcttcccaaataatctgacc
				aa
1317	2434911	—	NO	ctgagacgatgattagtagaactgagaagtgcccattggttttggtgagatagaggtcagacattaccttagcactttttggg
1318	2916250	C6orf162	YES	ggctcagaggggtgcgcacaacaaccttat
1319	3152957	—	NO	tctggcaaaacccaggtgcggtaaccctgcagcagcttccactcactcctgcaatgcctgaca
1320	3190622	SPTAN1	YES	gaagcttttgagacagacttcaccgtccacaaggatcgcgtgaatgatgtctgcaccaatggacaagacctca
1321	3508990	—	NO	ggatttctatgccacactacccgtaactttgaaaaataactttaggctgcagttttcagcaaacaggacagtccttagctgccacatagctcaacataaagtgca
				caaaaaacttcacggtgggacagtgaatcataaattcccaaactgacgtgtgtctacagaacagatg
1322	3567717	—	NO	ttttccatagcttggttctcaggggttatagatgcaagaagttcctggaaagagctctaaaccagaaaataacagtctgctggtcaaactcaaaactgtcttggt
				tgatatatgagctggctgtctttactgttacctcctgtcatgatcattttgctaattttctgctataactagaggggaatgtc
1323	3780094	—	NO	tgcgttagaagacctgccgacaggccggataaggccaatgagagagggaacggagaagaggggcacctgggttcacaggccttaagaaagaatttagt
				tacttatttaacaaattaaacaatgtgtgtcacgcatgtaggtctgggaaatgcattattaaaaacacacagtgcagaggtgcagcaccagcatacgggtgga
				tt
1324	3799938	—	NO	ggacaccctcaaccagtaacacacactctccttcttcaatgacgtttgtgttcctagaatccattttcctcagtcag
1325	3932154	—	NO	tcttgccatacccaagtagggaatcacttccaggaaaacaagtcctcaagcactcaatgactttgtaaacccatgactgaaacaagactcatctgaggcagta
				ggactggtgggattctactgacttcttagtatcacatggcaccatcacaaatgcattgttagagcagcaacatccagagttcttaagcttgtaccctaaca
1326	2534308	—	NO	cctcacagtgacacgcgatgttttcaaaagtccatctttccacaggatgtttacagcacccagcgggtaggcagtgctatttattaaccctgttgtactgatgaa
				caaaccagccggctcagggcagggggtgagcttgatcaagatcacagacaggaagtgacagcggggtctcagcccaggccatgcctgacacccacac
				tcttctctggtgggggcgcttccacctttgtccctggaagcccagcctgacagcttctgcagtgcctctggcagccgcccacaaacccagccaggcaaaat
				cccagggtgccagacaccaggagaaatttccaggggaatttggccatttggctgtctcttcacttccctgaaaagccaaacagagaatggatttcttatcaca
				ctgtagcaaggcaatcaactggaaaagagacaggaggagaagtgtgaggaccaacagtcacagggacccaggaatcgtgttagccaca
1327	3696944	—	NO	gctcccaaggcccaatcagatacagctctccaaacctgccagtgctggtgaacgcgctgctgggagcact
1328	3712853	—	NO	ggccgtgaaggaagaatgcggtgtt
1329	3916807	—	NO	ttcaccaggatacgactgttggaccagctgctggagatggacctgctacccctcagcagcctccccaccacaagacaagtgatctcaatgtccccaaacct
				gtgggaccctgttctacacacctcatttttgttccggcgtttcatcctccttgtgtgattgtactgattttcatgagacacaagttacttctttacatccatattcccaa
				agcagggttacatggtaggaaagaaaggaagttggaggtactaagctcattgtgtctcctc
1330	2381295	—	NO	aggaagtaactagagccggcatttgggggtgttgcggacgattcttacgaatccagacaatttgctcttttaaacgcggccttgcggttgtctaacagtgaga
				atagatgactaactgaatttgtcagactccctgccttctgtcataataacgacgcagaattgccaccgttatgtgtc
1331	2608169	—	NO	gtatggggagaacgaggatgtgata
1332	2363544	—	NO	ccacaagaagggctagagaaatacagagatatttgaagagtgtgaggaagagtattaacacaccagttttcttgatcaatag
1333	2407863	—	NO	acatccttcttttcggccttgaatcctttcttgctttgcaaggaacaattttcttcctactataaactacagcactaaggtatggaccttagaaattatatagtctaatt
				ctctgctgacacacaaatcccttcaacaacaaagaatcataagttcacattgaaaggtctctccaaatctcccataaatctacaatattcttgatgtttaaaattta
				ggataatagagaattcactaattcataagacaaagtaccaatgtaataattctataaaatgtcataatctgctttccttgtaacttctgcctattgactc
1334	2920969	FIG4	YES	aggatcctcgggcttatttcgagcggtttcagcttttggtg
1335	2949119	LTB	YES	tgcgtggtgcgagtgcgtgaatattgggggcccggacgccca
1336	3241194	—	NO	cattgggccttccatcatcagaaagctcctcatgccacatcttgacacattattcccgtcctcctg
1337	3447084	—	NO	aggatgtgagactgccgtggatatcagggaagggagacttataagaaggagaaatttggtcaactgtgtcaaatgcttcagcgatcaggatgagtaatgag
				gaacggccatttgatttgatttgatcattcagatatctttaaagacctttaagagggcagtttcagt
1338	3626136	—	NO	acgaccatgcgcactgagaaacaggcaccaggatgtcgagaacggcaatgtatttgctcacaaaaagctctacttcacacaccacctgtgcatgagcgtgc
				cacatcaaaatga
1339	3800039	—	NO	cataatcaggtcctctgcaagtgggagtccaactgtgacgcagcccccccacgttcaaagcatcccttcagcttccggcaatctcctctccagg
1340	3887175	—	NO	gccctggttgcaactctgctggtct
1341	4011861	—	NO	atgaggggaacggtagctgacaatagcagaggagggttttgcagggtctttaggagtaaaggatgagacagtaagtaatgagagattacccaagagggtt
				tggtgatggaaggaagccacaggcacagagaacacagaatcactttatttcatatgggacaactgggaga
1342	2320367	FBXO44	NO	ggtacaatggcatggcttctgtctaaggtacagaggggttggcatttcaggaaccaggccatcacagaaacaggttcatgggcagacccctcagtgagctg
				caggtatctcacctggcagccgtccagtactgctggcttcctctggaggcccagccacaggctggggttggggtgtgtggacatctctgggcagctcttga
				gtccaccttgtgccagatcagcagtgccaccc
1343	2680360	—	NO	gagctgggtcagttgctccattatgtactttggtttgcag
1344	2866718	ARRDC3	YES	actcgctacctcattcgaaggccgacatggcagtgtgcgctattgggtgaaagccgaattgcacaggccttg
1345	3251759	—	NO	gacaaccttcaatgcactggtactttgtaccctgacctctactgtgatgaacactcaacttgggcaagga
1346	3742688	NUP88	YES	tgtgttgagttggagcttgctttgaa
1347	3772092	LOC100131096	NO	tggctgtgcctctcgatgatgattaagatttcaatatttacagcaaaaccacaaagcaaatgatagaataaagcaaaacaatggaaaatctgagttcactcgtg
				agagaggtacgtatgtgagctctgaggaaattacagagggaacgcatgcagcgggacagctctcccaatcgcagcgtgcaaagtagacatcca
1348	2596545	—	NO	gacagcagagctatctatcagttcctctgaacttgttctgaatgagcttttcttactgttcagtattcactctcctattactgttttgcttcctcatagaattccagatta
				gtgggcccctggaagttcagctggtagatgagaaaactgagcccattgaagttaaagtcacccagctagtcagggttgatcttcccaactcagagtcccctg
				cttacttaaacttttatatccaacaggtttacttcccctggaaacttatttggtattttttattttccatctccatgccctcgataggtttc
1349	2928626	—	NO	cagccgccaaagacgcctgagagcggcaggggagtgtgttgccttaggacaatagcaaactgggacgtggtagagtctgtaaattccaagcactggg
1350	4035053	—	NO	catggtatcatgtgcctgtaatgtc
1351	2487210	ANTXR1	YES	cagggtcaagaacaaccagccagcc
1352	2891955	—	NO	ggcccttgacaaatgcctgaaatct
1353	3061185	ERVWE1	NO	ctcttcaaacaacaaccaggaggaa
1354	3104349	—	NO	atggacaagttaggccctccacttcgaacgggaagacttgtgcaaaggttgtatgacagtgatacaaaatcagacagtgcc
1355	3915245	—	NO	aattgggttcttgaggtggattggaggagaacagcctctggatgtctgctgggcagtgacgatgtgtctggaggctttgacattggattcattaggcattgcta
				atgtacacaaaaaatgtagcaaaaatgatgcctgtttctgggtgagaacatctg
1356	3961553	—	NO	ctcccaggtttacaggtcttgactcagtacttcatcagcaataggttgtggtcacaggaaatggaagctgcctcaggacctgtagcaacttgcctgcatgctg
				ggttatgttatcttttgagtggtgcccaatacgaggtgtctaggggaaagtcttaagtggttggagcccatgaca
1357	2523501	NBEAL1	YES	tctcacagtggaattcgtccctttctt
1358	3601127	—	NO	gtgtgtttgtgcaagcatgttaagcatttctctgtcttgtgttcatt
1359	3892321	—	NO	tgcaggggtgtccagacggcctggtgcaggatccctttgatgtggagga
1360	3087823	—	YES	ggaggatgttcggactatagattcagctgtgggatctggttctgtagctgagagcacatcgctaaacatagatgtgcagtctgaggcttca
1361	3337295	—	NO	aaggctacaactgtgctcttagaggcaaaagaagaaaatgagactgccaggcatgaataatgagaaatctttgatggaattagccatgcagaacagata
1362	3528558	TRA @	NO	tctttggtcccggaaccagattgtccgtgctgccct
1363	3536444	—	NO	cttttctctgtagttggcggaatcagctcagttacattttttactaagttacccacattctgacactccttgacagttttaagatcttcttctaacacacttgaatagaat
				ggatactggaatctattttgacagctgttgaaaatctattctgttgttacaggaggttaaggaggttatttgtaacactgggattatttaatgaaccttttgaaaagg
				tgtgcagactgttcaggcaaatagtattttttagaatttaaatgattttggttttcacagttaaattatcaaatgtaatgcttttaagaattatacacctagtaatatttttc
				attaattttctccaccagtgtagtaatagtacattacaatgttctcaattaccggtgccttctaaaatgcaggtgtagagtctttaaatacagctagtctattgccag
				ctgtcccatagataaccttctttaaaagtgacctttgagcaatttcataaagaataaatatttctagttttttgttgctgaactgctaaaagatggttctatacatgt
				aacaggtggctttagttgggttgctt
1364	3823557	RAB8A	YES	atggcgaagacctacgattacctgttcaagctgctg
1365	2707806	—	NO	cagacccttgtggtcgagttgtttactttggtaattaagtacctgactctgctggacgctcttcgcgtttcagaagcgctgtttggcattgtacagtctgagcgtga
				gttgaattcc
1366	2849541	—	NO	gttcttcataaatcctccactcacaagcttgcagcctttcctatcacagtcatatccaatctcaattcccctgcccagtataatgggactcga
1367	3795889	—	NO	acgctgaccagtgaccgaggacacagttgtgtgttaggctccatcacctgctgtactttgagttgggaaattttcatcatcttagaaactgggtcattttatcaga
				gtctagagtcagatatagaaaaagtttgtggctatttctccaatttatatgactaaggtcgggtatctttttcaaagtgtctaattgaaattgaaaaggcagcaattt
				aaagttgctattgcaagggcagaaaatggtcttaagaaagccagctttcaaattgaataaacatgactgcgttcactttttgagc
1368	3895772	—	NO	gaaacaaactgacaatactcgtgaaatcaacacccagatgaggtagaccagcactcca
1369	2920915	—	NO	ccaactcacaccatagcagcgctcatt
1370	2971825	MAN1A1	YES	ctggaggcagcagtattctggcagaatttggaaccctgcatttggagtttatgcacttgagccacttatcaggaaaccc
1371	2990655	—	NO	ggtttcttgataactgctccacttagagaaatgagctgtgatctgtgtagattttggaaaatgggtagctggggggatcatctttaaacaatctttttcatgctcatca
				cgaaatgcttttacaataggtttattttgactttgtgtttagaatttttttttttttttgctttttgctatagactctttaaaaaagttgttgttctggatattattgatagatgga
				acaaaattcatgtccttgcttgaatcttttagcgagctattcagagattctatatccccatttactcatggttttttcaaggtgaatgaaacaacataccctgct
1372	3198975	MPDZ	NO	tgcactggtcctgacaatttttatgctgtgttcagccgggtcttcaaaactgtaggggggaaataacacttaagtttctttttctcatctagaaatgctttccttactg
				acaacctaacatcatttttcttttcttcttgcattttgtgaacttaaagagaaggaatatttgtgtaggtgaatctcgatttttatttgtggagatatctaatgttttgtagtc
				acatgggcaagaattattacatgctaagctggttagtataaagaaagataattctaaagctaaccaaagaaaatggcttcagtaaattaggatgaaaaatgaaa
				atataaaataaagaagaaaatctcggggagtttaaaaaaaatgcctcaatttggcaatctacctcctctccccaccccaaactaaaaaaagaaaaaaaggtttt
				ctaatgaaaatctttaaaaaatactgtcagtattttaaaattttcaacagtattataaaaacattgcatctccccacctctaatatgcatatatatttttcctgctaaaatt
				ggtttctacaattgagtaaatggcaaatacatgaagcaatgtccctaaattttataaagaaattatatttaatgcacatttcaattttcattcttattttgaccttttgta
				aaatattttcatgttgctataagtaaatgatgatgccaccccatgttgactatggtttttctagaaagcaactatgctgctaaccatagaggaacatagaagggtt
				ccagaatctttagtgctggttttaacaaccgatgcaacattaaaaatgtgttagtgtgctgtgcaattggttttcaattcatattaatcttaatgacagagaacaatg
				tgttactaattattttggttgtatgccattagtaaattgatagaaaaattaaggggattaacataacttcatttcattgacttatattaacatcttataatacaatagttta
				agactaagggaaacagatggagctgtttattgagacaactggtga
1373	3652974	—	NO	ctgacatggtgtgtcacaaagagctcc
1374	3680296	LOC388210	NO	gtagaccctacaccattcctcagcc
1375	2530462	COL4A3	YES	ttccctgggttaatgggtgaagatggc
1376	2550272	—	NO	caggggcaagagctagttagaaaactgagctcgccctgtctctaatgtctggtgagctgctctcctctctctacaatatatcacgggtagtttcatgtcaacaaac
1377	3118585	—	NO	gaatatgttgttaagtgggcagcat
1378	3403090	C12orf57	YES	taagtttgctcgcttggtcaagtcctacgaagcccaggatcctgagatcgccagcctgtcaggcaagctgaaggcgctgtttc
1379	2524930	—	NO	tgtgaacttgggttgtgtcgtagaaaatgtgagtgtcagagag
1380	3125787	CNOT7	YES	ggttacgactttggctacttaatcaaaatcctaaccaactct
1381	3171102	—	NO	ccaaggactggcaggacgtcagtgatgctggg
1382	3250113	KIAA1279	YES	cctgagcatataggggaagatgttcttcgccctgccatgttagctaagtttcgagttgcccgtctctatggcaaaatcattactgcagatcccaagaaagagct
				ggaaaatttggcaacatcattggaacattacaaatttattgttgattactgtgaaaagcatcctgaggccg
1383	3747008	—	NO	ggtgactggaccacgcaggtagtttctcatgaatgatttagcactgtccccctactgctgtctcgtgatagagttctcatgagatttggttgcataaaaagtgtgt
				agcacctcccctctcttttcctcttgctctagccctgtgaagatacctgctctggctttgccttttgccatgagtaaaagctccctgagacctccccagtcatac
				ttcctgtacagcccatggaaccatgagccaattaaaccttttttctttataagttacccagtctcaggcatttctttatagcagtgtgagattgaaccgatacagac
				aacaataacaaaaagtagataaatatgaaggccagagaaatggcaacttcttcacgaagggaagctgcttatcctcaagcaagtcagttgaggactatcctg
				tgagctattttccgtgccttgttttccactcatacagggaagtatgccctggtgtctcacagttgcttcagttcttctttactgggaccctaaatataataacacact
				gaaccactcaacttctcagaccttcaatatccctggggctttttctcaaatggacacagcatagctttcagaaagctgaataatgtagacaaaagaagtctccct
				caccctttgattatggaaaaccaaagatttattcagtgccaaggataagaaaggaaggacttgatcaacaaccactgttaagattttgacccattcactacttca
				cgtgaactcccagggaaatggaaaatgaaagaaggtctccgcggtagagggataacaatg
1384	2406715	—	NO	acagagccctgattccacatacatgagctcccatgtgtggctggggctctgctgggtcctgggggcaggaggaggatggagaggcaggccctaccatgg
				aggaggttgtgatctaggggcaggctcctaaccagttaacatgtgcacagtttggcaagtctctcacagaagtctatagcatgtgggggaacccagtggaa
				gaagtgatcgagctctaggatgaggaggagactggggagaacttcagagagcccttagaacttgaactgggactgggcac
1385	2808962	ISL1	NO	cctccttggctgaaagagtcctttcaggaaggtggagctgcattggtttgatatgtttaaagttgactttaacaaggggttaattgaaatcctgggtctcttggcct
				gtcctgtagctggtttattttttactttgccccctccccactttttttgagatccatcctttatcaagaagtctgaagcgactataaaggttttgaattcagatttaaaa
				accaacttataaagcattgcaacaaggttacctctattttgccacaagcgtctcgggattgtgtttgacttgtgtctgtccaagaacttttccc
1386	2849483	—	NO	cctgttggtgtgtcgataatggcaaggtctgcagtgacccagcagtggctgaggtggggctggggctgagaacctgatccctgagaggccatttattgtaa
				gaacaggcaacatggcagggaagtgaccaggaactaggacaggcagtaagtgggagagaatgacggcaagcctggagctgtcccagaggtgactga
				cggatgctgtacaaggtggaa
1387	2868168	ERAP1	YES	atttgccctacagatggtgtaaaagggatggatggctttgctctagaagtcaacattcatcttcatcct
1388	3082899	ARHGEF10	YES	atggagttcgagtgaatttgaaagttacgaagagcagagtgactcggagtgcaagaatgggattcccaggtccttcctgcgcagcaaccacaaaa
1389	3505964	CENPJ	YES	gctgagaacgcatctttagctaaacttcgcattgaacgag
1390	3522535	DOCK9	YES	caaagctaattgagccactcgactatgaaaatgtcatcgtccagaagaagactcagatcctgaacgactgtttacgggagatgctgctcttcccttacgatga
				cttt
1391	3404455	—	NO	cactagacagcaattcagagcctccaaaataaagaatattcataaaagtaacaatagaggtaaatataaaacccagaattactacatgtgtcatatagtttataa
				cttctcctatttatagctttctatatttatatttatctataacttcataggcaaatgaataaaaattataaatatgatagtggtcatataatgtataaagatgcaatctgtg
				acagtcttatgaagcagggatgaagacatataggatcaaaatgtttgcatagttattgaagctatgttgatattatgaaattatattgttacaagtttaagatgctaa
				ttataattctcaaggtaaccactaataaaattaccaaaattatgcagaaaaggaaaaaagaaaaacaatacactataaaaaaccaattaaatacaaaaaaagtc
				agtaacagacaacttgagaaacaaagacatataagatatagagaaaacaaatgattaaatggcaaaagtaaatcttgttttagtaatcacattaaatagaaaag
				gatgaagccatcctattaaagggctgagactgacaagttggctaaaaactaaaataaattaaaaagaaaaacaagactcatctacatgctgtctataagagac
				ttgccttagatataaggacacaaagaagttgaaagtaaaaggactgaaaaagatattccatacaaacagtagtaaccaagatagtgccgagtggctatattttt
				gtcaaacaaaataaactaaagtaaaatttacaagagaaaaagaagggcattatgcattgacaaaaattttgacatagccaaataattatgttataaaatatatgt
				acttaataatacagcctcaaaatatatgaagcaataattgctataatttaagggagaaaagaacagttctatgaaaagttagagaatgaaatattccactttcaac
				atgagattaaacaactagacataagatcaataaggaaatagaaaatttgaacaacactataaaccaattatcc
1392	3309338	—	NO	ttccagctcatcggcgttgaggtgcac
1393	2475878	—	NO	gctgctgagtctcaaaacagccaaa
1394	3032635	—	NO	gaggctcctcttcctatggatttgcttcaaggaggtcagggc
1395	3475556	VPS33A	YES	attacattgaggattgtatcgcccaaaagcactcgttgatcaaggtgttaagactagtttgcctccaatccgtgtgtaatagtgggctcaaac
1396	2930679	—	NO	gatcaacattcttaatgacataagagaagggagttgcaggtggatctaagggaaaactgttccagtagtaaaggagcagcaaatccgatagccctaaggga
1397	3489376	CDADC1	YES	ggatcataaaacaggagttggggcag
1398	3933755	—	NO	gtttgcatttgaccatgtcgtgggcaggaga
1399	2430088	—	NO	tcattcttaaggctaaggtggcaagataa
1400	3420474	—	NO	atggaagcatgttggcgtcatcagcagagacagggaaattgggaaggagaggagagcataattagtgtgcagaaacttggaaatgctgacattggactcc
				tggcaga
1401	3956302	PITPNB	YES	gactgtccccagatgtgtgcctataagctggtgaccatcaaattcaagtggtggggactgcaaagcaaagtagaa
1402	2334264	hCG_1820661	NO	ctgctcgctgagatagacacatacctgattgcctcctttggagaggcttgtcagaaacaaaataatgcaaccatttgtctctcagctacctgcgacctggaagc
				cccctccccacttcgagttgtccccgcctttctggacggaaccaacgtacttcttacatatatcgattgatgtctcatgtctccttaaaatgtatgaaaacaaactg
				tgccctgaccaccttgggcacatgtcgccaggactccctgaggctgtgtcacgggcacgcatcttcaaccttggca
1403	2358760	SCNM1	NO	cagcctggtgccctattaataagactgtcaaaaagaggtctttgcccttcatgttgtctgcctgcttctccactaccactcaaagtcctttcccccttcaaatcaca
				taaggactgcaggtaggcactagggggacctggccacatctggaaacagggctgtggctaagttccctgtgaaagtagaagagtcaaaaggcattggca
				gggttatggggaacaccaagggagggaacacccccacctcctcctagtaacctgaacctccctgcctgctgatccccagagtataaataatcccctggtga
				actggcagtaacccttgggggttagcgccaagattctcaccccaaagcccaaggaaggaggcaggcaaaatggatagaagggcttttatttacaggaaag
				gaggacagatgaggatttaagtgtccagtgctcccagcgctagttggtaaagggaaatgcagtgttatctcttcttttgctggcgacctgtaa
1404	4005886	CASK	YES	tcatcacaaagcacccagaccggtttgcgt
1405	2440191	—	NO	ctcctcacccgcatcataactcctcttcaag
1406	2561968	SUCLG1	NO	aactgtggaatggatcacgtagacatgtaacccagcagcagtttgcttctgttgtccactgattaatcagcctatgtgcctgacactggtcttgca
1407	3216427	—	NO	atgttgagaaagcatatgcatgtgacagggcggatttgttagaagc
1408	3235909	—	NO	gttagactcggggttgatatctgtcatcgctgt
1409	3469137	—	NO	agcaacagaaagctcgtggtgttcctctgcctcaaaggccaaacgtctgtgggttttttgtcttggctgccgaccgcagcacgtcacactgtttgaaatttgca
				gctgcgatcatttatcttcaggggacaggggt
1410	2343471	—	NO	gacagattgaaagaggtggtgaagc
1411	2464386	—	NO	ggtacacacattaggagactgcagttttggtgagaggtgatggaagctcgagactagtgaggaaaagggaggtgtcaacatgagccctagattcttggagt
				ccagaacttgaaga
1412	2672266	ALS2CL	NO	gtgtgagcatgcacaggttagggtgggctg
1413	3730349	—	NO	tgggcctttcaaattgagtctaagtttaaaagatataaagaggtgtgggggaagggcattcctggcagagggaagagcatatgcaaaggtgtggaggccta
				gaactacactgcagctttaaggggtggtgagtgatggccgggcaccgtggctcacacctataatcccagcactttgggaggccaaggcaggaggattgct
				tgagctcagtagttcaagaccagcctgggcaacatagcgagaccctgtctctgcaaaatatttttaaaaaattagctgagtgtggtgatgcacgcctgtctact
				aggga
1414	3755723	MED1	YES	ggctcctccatagcagagaaatcttatcagaatagtcccagctcagacgatggtatccgaccacttccagaatacagc
1415	3861643	—	NO	ctggcaagcagacgggtttggaatagacattggaagaagcttttagggcatcctagacagcgttgcgatgcttggggcaggggcaggaaaaagccactg
				atggactttcagggcagagctgtaatcgagttgatgtttcagatttagtcgaagggtgtgagagggctgagacggagaaagtggtgtggcagaagaggttg
				ctggtggccatgggtcggggtgcagattatgagagaactc
1416	3542787	PCNX	YES	tttgatcctatgtgggagcgactgaaaatagaatgagcttggttaagcacctctcctttgcc
1417	2468417	RNF144A	NO	tgccaccaaaggcatggctgtgggc
1418	2520238	NAB1	NO	gggaggaacatttaagctgatggaagtggaagtggaagttgctgtacattggcagcaaggcctccgagttagcttttgaatgcagttaactggtttctcttaac
				tgtggaattcattgaaaagtcagactccgagtggtcgttccaggatatctt
1419	3129693	—	NO	cagcctgtgtgtactcatttccttctcttgagtaccactaatttgatagttcacgtatcctctactaagaggtagagtgagacagcttagggacatcagaagtact
				actttcggttcttccacatggaaacatgaggaacgaggaataagtattctttccctaacacttacagtgcacttaagacaaagttttttttttttttggactgaatata
				cgtcgatggacacaggcccagatatggagaaagggcaggtttcctctaggcaagatttgcacggggaacctga
1420	3845840	—	NO	cctggatccctgaagactgctctgagatcgatcagccagagagaaacagagagaaagctggctcagccctgaaggctttgagcaaaagtttcagaagga
				gctggaaggagacaacagcccgttctccctgagctgtggccgggagggcccaggccagcaccacgatgtacagatggcccagggggctcgacatgag
				tgagggctgaagttcgtgcaaccccaaccgccacccctgaattgggcagaaccaatttttttcttagcacctgtctgactctgcttaccatgacaaccccaag
				ggccccccagaattgatatccaagtgcctttagcctatcaaagacaggagggggtgcattctcggccaggttagggttcacagagcatccgtatatta
1421	2621185	NBEAL2	YES	ggctgtagacctggaccatgtgacagatgagcgggaacggaaggctctggagggcattatcagcaactttgggcagactccctgtcagct
1422	2871234	—	NO	tttgctgccatccatagtcttttcctaagtatcacaaaaggatatgcctgccaatctcttaaaaaatgacaatgcagacttgtgctcaaaatgaagctacagattta
				gaacctcagattcaatgaactaaaaggagaatatattaaatgttaaatttgacctcagaaattccactatactaaggatgttgcctaagacctctcaaagactga
				ggaccagcagaacactgcccatttcactctagaaccacacacaagtctgttgttcccaagccaatgtgaaagctataagccttgagactcaaaagagcaca
				ggtgtccacaggtgacccaaacatcaaa
1423	2904825	C6orf127	YES	ccaggggctcactttctccaacaaaa
1424	3133366	—	NO	gtgtcagtacagccgcgtggcagagctga
1425	2577848	—	NO	ggcttgcatcagcacacattgtacagccttgcaaattacacagaaattgaaaagaaggttccttgttcataagtgcaatgaatctttgatgtccagtgatccgct
				gcaaacaatgaaaacaaactgtaaagcacttaagaagtttccagcactcatcaaatgcatttccttaggtgacaaaaaatccacaaggagaatgcaaataagt
				ggcatttagttattagagagatacttgaaaaaaaaaaagtggaagtattttcctgcttagaatgatttctgttcccctttgaatgtaagtggtttaagaggcattaag
				aacataatttattttatacttaatgttcacactacctaaatgaataaggaaagggccctacaaggaagagttatgtattttttggtaattgtttctgagtttagagattc
				aggggaagagtaatcctctatttgtgggctcttcttagcatccctaacccccaaggagatagtacatggttttgacttggttatttcactcctgcattctttttcccc
				caaattttaagttgggtcacattgtgctggctgcaaaa
1426	3332349	—	NO	ggggatgtctgcaatgtcagcactgattgcagcaccaaactcaaagacaataccactcatgccactgccaacatacccctggcttcctcaacaactttagaat
				tattatattgccctaagtgcatctagaata
1427	2416733	—	NO	ggaaaagtacatgccagaagtcagctgtgcagtaacctatgagagagctactcctgtttcaccccagatcatcacctcgattccaaag
1428	2437457	ASH1L	YES	aagcaccagttgagattcccagtccttctgaaaccccagctaaaccttctgaacctgaaagtaccttgcagcctgtgctttctctcatcccaaggga
1429	2704212	—	NO	gagattgatgtggttgtcagctaaacctgctctttcagtagtggaaatt
1430	3888795	—	NO	gttgtttgccttgacagtgcggctgcgcttcggcctgctcgggttaccagggaacaaggc
1431	2556326	—	NO	ttgcctcagctgactttaccaaaaattccctttcccttccctgctttaagtcatttcatgtaggttagtcttcatttattcttttgcctctctacagtagttattgctttgtgc
				tgtacatttgggttaaaggagttgtatatgtgtatggtgacagcataatgcctctgaagcccaggacctagctacttcttagctcctaacgtaatttcatccatg
1432	2878702	—	NO	gtcagagtgtataaggtgaaatgccgttctgtttttggag
1433	3328538	—	NO	gccatccggatgtcagctctgtggacattgactgctggttttcctggggcctcggttttcctctctggcctggcatggactgcctcttgccttggagttgctggg
				atggtggggtgtgtgtgtgagtgagagtgtgttgttggggggcagtgccctggagaggacttcatagcct
1434	3496801	—	NO	aggactgtgtggcggactatgcagcatagt
1435	3668198	—	NO	tccacagggcagaaactattgcagagttcac
1436	3764547	4-Sep	YES	agcagtatttccgagacgagagtggcctgaaccgaaagaacatccaagacaacagggtgcactgctgcctgtacttca
1437	2544277	ITSN2	YES	ggagtgctagcaagtctggagcatcaaataaa
1438	2581567	—	NO	agcagtttggcagccacatggattga
1439	2612556	—	NO	gcctgggggaatccgtgaacgccta
1440	2894809	SYCP2L	YES	ggtgtattcatttccgtgtattgctgcttt
1441	3956007	—	NO	gacagtcttcagaaaagggcagctgg
1442	2407214	GNL2	YES	gaaacacacgtgtgattaagcagtcatcattacaaaaatttcaagaggaaatggatacagttatgaaggatccatacaaagttgtcatgaagcaaagcaagtt
				accaatgtctcttctccatgatcgaatccggcctcat
1443	2948537	KIAA1949	NO	tctttctcacatcctagagacggtctttaatacgcattaaccctgtgctgccacatctggctcctgccctcattgcctccaatccggactcttcctctcacatca
1444	3991159	—	NO	acaggtggactgcagggtcgtcttacaaaatgacaag
1445	2444356	—	NO	tagaccctgacattcagctccaataatggatgtcccagtatgccctgaatccaaacaaatgcctgactgcaataa
1446	2480997	MSH2	YES	agacaggttggagttgggtatgtggattccatacag
1447	2671526	—	NO	atgttccttccaaatctcacattgaaatgtaatcttctatgttggaggtgggcctgttgggaggtgactggatcgtgggggtagatttctcatgaatggcttatcgt
				catcctcttggttctgtccttgtgatagtgagttctcgtgagatcatgttgtttaaaagtgtgtggtatccctctgccttgctcttg
1448	2673140	—	NO	aagaccacattgagccacctatctccatctgtgcttatgtactctgcttccttcttgttaggatgaacaatgggcgaaccttccaagttcctatttaaagttacccc
				aatctgtgcagaagatcctgtctcctcccacctactcaaggcattactctggca
1449	3394422	THY1	YES	catgaaggtcctctacttatccgccttcactagcaaggacgagggcacctacacg
1450	2485881	—	NO	ggggtgacattcagattcaatcggtctacggatgagaaa
1451	2572007	—	NO	aggcttctttgacaatcgtttctgatctttagctgagtctagatggtaaaagtgaactagtgaaagggaagaatgagttttgttttggatggcatctcattattttttat
				tttctttttatttatatatttgtttttcttatttttttttctttttgattttaatacctccaccctacttacagatattttttattttcttgacaactctgataaatg
				atggattggaggatcagacttgttgacatcactgatgaggcttgtcttgttgcttgtcttctctggctaacattccttagtaaaaatatttct
				atatttttttctttattttatttggtcattatttcattttgagcttttttcatttattactagataagcgagttttgagtgtcaaatttgcacttaatttgttttt
				ggtactgtcataaggactgtagcatacacagcatactacaactgtaactttttacgaaaatatacattttttgaagatgacttcagaaa
				ctgagggagagagacccacttgagactaggcagcaaacagtgaagaagaaatgagcaacatggtgtgcaggagca
				aagtttcctactgtatatctctactctaagtgtacaatgccta
1452	2804366	—	NO	gatacttcatctagtaattcctgcccaggttttgaaacctcatgctggaccctcctgtgcaaggctgccctgctcattctgctctcatctgatcctctcactgggcc
				agtc
1453	2369480	FAM20B	NO	tcggcaattgctcattctagggagggcatcatagttggtcagtcttaattcccatgccaaaggacaaacaggtgtgacatttggatagatgaatactgggattg
				gctctggagcatgtgttttgagttgaaccttgcagtcctttctctacgcccgtggattttgtggaaaca
1454	2556336	—	NO	agtcctgtctagtggtcagtcctaacagtgtggttaaaggggagctaaatttcaactttcaggggtcagctgagacaaccacctagattttccaagttagttcca
				atttcaagtacaataatcctttgacaacatagaaaagaattatagttagcaaaattgcaattgtcacagtcaaggtcttgttggtaatagagggttggggaaaaa
				gttaaaacagcattaaatgaatatatttttaacataacaaaagttcccagaagacatccacttcaaattcaagccatattcatcaatgttaaaaaccttactcttctc
				cctgatagtgtgaggaaaa
1455	2589618	TTN	YES	cctatccctgtaaagcctgtcccagaag
1456	3405368	—	NO	ctggggcataaaaaagcaagtgttctcactgagggatgaatagtctactagcaactgtaagacagttgcacgaataatgatgatacaaagaggtatccgatg
				aatataatgtagcaggataaacaaaatggcagtggaaaacaggagtaaaaccaaagggaaggattctgagaagactatttataatgggaactaaaattgtca
				gctgaagctcagatggcggtagaggcattccagatggagtatagaaaatgaatgaagaccaaggacaggacagaaatatctggggtgcactcactaggt
				gagtgtgtccagacattgaaagaggatgagcagaggaagagaacaggagaggtaagaactaaaaaggtggtattaggtcctggaaggtcttaaatatcaa
				gctaaagagttttactgccaagctacagaactttatcaaatgccatactgagaagactgatcgatttattaaagcaaactcctaaaggatctcttcttggaaaca
				attcattagtggttagtgtggaatctcagtgtggcacggaataaagtaaagtacatgggtaacggccccagaaaaaccagagcacagcccagcgcattacc
				actcatcgcctgggtgatcttg
1457	3447472	—	NO	ttttaaggagggttgcagaaagtga
1458	2331932	—	NO	tgccggtgcagttccttggtatactga
1459	2413973	USP24	YES	tacgtcgatggagttcagcacaagcacgagaatttgggaatcttcacaatacagtggcgttacttgttttgc
1460	2972147	—	NO	aagtcaggagggttcagtgaccaga
1461	3568132	—	NO	ttaggtatttcgagtttgaagtgtctataagtcatctggagctgtccaggagatggttctatacatgaagatcaggaccagtttcttgtcatca
1462	3593984	—	NO	ccaggtggtctagcgctcctaacaaacaccttatgattatccttcattcaacagaggaggagactgcaggcatgcttcagtcagtggtaagaacaggaagaa
				aaacccaaatcagcaacattttcttccttaatttggtataaacgtccttttcattatttcaagttactaatttgctaatctcaaatgttttctgaatcaggtttgctaaatg
				ctgtaaagaatagctatccttcatacaatactaggttttattttttttagtatgtcagcataataaggtacatgcgcattcattccaccaacctgtttagataatactca
				gcttgggtcatattcaaattctacacagagattctctgttttcaatacaactgcttagaaagcagaattgcctagtgatgactgta
1463	3878647	—	NO	gcagcccatcccgaagtgcttattacattagaacatttagtgcttttaaagatggtgtgtgtgtgtgtgtgtgtgtgtgtgcgtgcgtgtgtgtgtgtgtgagaga
				gagagaaagcatatctaaatgttggtaccaaatcataccccattggaaagattcaattttctgaaattccacctaagaatttttgtatgtatatatgaaggcaattgt
				gaaattatagagaattagcaaagtttatttagaatttgaggggtttggagtgcagttttacagattttctgactctcttttctttaatgtccatgcagagactaacata
				attgacttttagatctttatccagagagtcaatccaattcaattcaaaaatgtttattgccagtccactctgaaca
1464	3271123	—	NO	gtgagtccctgggtcagtgagcaca
1465	3291284	TMEM26	NO	gaaagtggcttatttgaggttgttggtgctgttggtattattgccatagttgttatttaattgcttgattaaactcagtcaaatatccttccta
1466	3859781	DMKN	NO	caaggagccaccagattggatgggagcccccacactccctccttaaaacaccaccctctcatcactaatctcagccttgcccttgaaataaaccttagctgcc
1467	2326309	—	NO	ccttcacggatttggttggggtcagagaga
1468	3091040	BNIP3L	NO	agtgcattgtgctctttccaagttcagcagcagttctatcagtggtgccactgaaactgggtatatttatgatttctttcagcgttaaaaagaaacatagtgttgcc
				ctttttcttaaagcatcagtgaaattatggaaaattacttaaaacgtgaatacatcatcacagtagaatttattatgagagcatgtagtatgtatctgtagccctaac
				acatgggatgaacgttttactgctac
1469	3823592	HSH2D	NO	ggggtgcttcatgtcatagcttctcagaaagcagcagtaactgaggctgtggatctgagaacgggagctgctagccaagcaatgagtgaagcttttgtccgt
				agtggcatgttttatctgaggccagcctttgtactcctgtgtta
1470	3551323	CCNK	YES	ctacaccacaagtgccgcaagtacagcagtcacagccgtctcaaagctccgaaccatcccagccc
1471	3602745	RCN2	YES	atggatttgttagtttggaagaatt
1472	2332284	—	NO	cccggcgcgtatcgtaggcagtgtaccgtggccgtgccgtcagagtgtgcgtgtgcgtgtgtgccgtgtcgaggctgtgtag
1473	2689891	—	NO	ctagaactatattagctgctcagtgagttgggcaattggatatttttggttttatgatttcagattttatagaccagtggaatacaggccttgtgcatatgaagatca
				ggtgacaagtttgc
1474	2952713	—	NO	tgtttgttgtttggttatgatcttgctt
1475	3181289	TMOD1	NO	cggtggagtccatgcctttgaactggatgtgttctattgatgacctgtgctctgcaggggaaaccagaaggcaaaatgctggcagcatgaaacccttttgtgg
				ttcagttctttatgcactaaggttttaggttgactagtggttgtagttgaaaattttataaaataccgttaatgtgaagtttttctttagtcacagaagttgaatctggtt
				attatttaaaaactagaagcccccaaaccagcagatcttactgaagatgatgttccagcagcagcgacttagccccaggagcccagtttcaatggccttgctg
				tgtggtgtttcaagtgcatttaaaatgtgtgacacagaaacggcacactcttc
1476	3412443	—	NO	acctttgacatctctagcacacggagcaattctagatggttgataaaagagcataaatcaatcgacacaaatatccccttaaaccttgtctttcatgtccagtatt
1477	3886313	TOX2	YES	atgagtgacggaaacccagagctcctgtcaaccagccag
1478	3976557	RBM3	NO	atgggacgtttgtagaacctgagtatttttctttttaccagttttttagtttgagctcttaggtttattggagctagcaataattggttctggcaagtttggccagactg
				acttcaaaaaattaatgtgtatccagggacattttaaaaacctgtacacagtgtttattgtggttaggaagcaatttcccaatgtacctataagaaatgtgcatcaa
				gccagcctgaccaacatggtgaaaccccatctgtactaaacataaaaaaattagcctggcatggtggtgtacgcctgtaatcccagtgacttgggaggctga
				ggcaggagaatcgcttgaacccgggaggcggaggttgcagtgagctaagatcgcgccactgtactccagcctgggcaacagcgagactccatctcaaa
				aaaaaaggaaatgtgtatcaagaacatgattatccagcggtattttctaattcagatcatcaaactgattatatagaagagttggctttaaaatgtttgcaaatgtc
				tttttttttttaatactggaagaaaaaatattctgttgtgtctcatacagtgcttaggatgtctttc
1479	2635686	PVRL3	NO	ttccatagctgtagctggagcggtaattggagctgttcttgcccttttcatcattgctatctttgtgactgtgctgctgactcctcgaaaaaaaagaccatcctatct
				tgacaaagt
1480	2680971	—	NO	agttggcttacaacctgtgctgtattga
1481	2715956	HTT	YES	ttgagttgtacagccgctggatcctgccgtccagctcagccaggaggaccccggccatcctgatcagtgaggtgg
1482	2452913	—	NO	ctgtgcacaggactcctcaaatattttccgtt
1483	2667796	—	NO	caagagaaggtgagcatataacaggtaaataacagaagctctgattttttttttctttttatagtttgggactattcatccagcaagagaaggacgcttaaaagta
				gatt
1484	3602153	C15orf39	NO	aagggattctgatgagccgatgggccctggaggcagcccattaaagcatctgg
1485	3752031	CRLF3	YES	taccaaaaaggcctcgcacattcagttggacag
1486	3765307	APPBP2	YES	ggaaactgaacagaggctgcttcaagaagctcatgatttgcacctgtcttcactccaactagctaaaaaagcttttggggaatttaatgtacagactgcaaaac
				actatggaaaccttggaagactt
1487	3956644	—	NO	gtacatgcaaacgggatgggagcag
1488	2345202	—	NO	tgatgcccgcgttgtcttttcagactctgttttttgcctttagcatgccttgtaatttttttttttttttttgataagctggatgtgacataaggggtaaaaagaactgaga
				taaacaggcctttagtgtggcctagaggcctatctggctaggagttaggctgtgtttactgtttgatgtagctttggtgtcagagattaaaatttcctctcgtgtaa
				ctgcttttgtctcctttgttgtctttgggtttccctaataactccttcataagtaggttccgaggcttgtagttatttaagctgtaagtccctgttattacacaggagcc
				ctattgatgtggtgtgtgtgtgtgtaaaagtgttctataatcttatgattagctcttagtgagcctgtgtctttggactgtgaccttcatgagtgctttttagc
1489	2655521	ABCF3	YES	aaaggagagtcggttggaatcatctggcaagaacaa
1490	2920283	—	NO	gcaggacatacgctaaaaccggagcaatacagagaagattagcatggccctcacccaaagatgacacgc
1491	3102056	—	NO	agattacaaactcacatttaatgttataaatgcagaaaaaggccaaaaacacaaaaagagtggcaacgagggacag
1492	3161310	—	NO	tgaagaccttcacgctttctctgtaagttttcattcaaaacatctttcaatttcttttttttctttttcttcttttttgccctcattttagttagtttgagtttcttgtggctctgta
				gtgactgctctaatagaatatcccttacaactttgtggcagttaatttctggatgatcactgtgacttccatttacatgtatttgg
1493	3289083	—	NO	acaggtaaattaggacggcactgcgggtactctgtgttccgcctgctcaagttctagacttctggtgtccatagcaacccagcaga
1494	3304760	—	NO	cggggaggaaagacagctctaccag
1495	3895434	C20orf194	YES	tctttcctgggcacttatctaacag
1496	3406522	—	NO	tggttttgtggataggggaaatctagtagatattaaatatttttatctgcaaaaagcatttggtaaggttctcaatgggagattaatgactaaaataaagaatgagg
				cattaggagataaatttgcttatgagcaagagacagatactaacagtagaaggaaatactttttagattggaaaggagtgacatatagcacaagccaggaatc
				agttttgggaccta
1497	2692051	—	NO	gtatcggattaagctcaaaacgggaggaggaaacaaggatgactggagtcaaggaa
1498	2835105	LOC728264	NO	ggcaggggttgggacaagtgctaagtatgcaagactcaagggaagagct
1499	3935012	—	NO	cttctccaggccagatttaaccacataaacacatcaaatcccagct
1500	4038282	—	NO	tggctgggtgagttctaaaaatgcccaagacctccaagactaggtgagatctgaagtaatgaaatgcctccattcactaaaggcctgaaattgtcctgactgc
				ctcag
1501	2856770	—	NO	atgttcaaccagatgatgggccatgattgt
1502	3579731	—	NO	cccatgtgtatgctttgagccgttccttagttgagtaggtgattgaccataccagcagcactggtgccaattaagcggtctgcttggttcacacagcctttcattc
				ctgttctagcatggctctgtcttaaatctgcatgcatgtatttattccttaatatattacctctcttcctttcttcctttttacatttcttcccattttttattgtttctctctctct
				cactctctcactcattctctcttgcactttgtcttcggagctcattgccatggagtggcttggctgtacgcatcaaaaagccacccgcaaacgtccatccttggc
				cgtgcggttccacgtctcactcattacttccttcctgcattcatagcatccttccttcctgcttgctctctttttattaggcatttattcctctattagtggagtcaggtg
				cccttatgacaagtcctagc
1503	3636549	—	NO	ctactgaaagcatgtcctgtgaatgttacttgtcagtgacaaaataggtacagaaattgaaataagagtttagaaatttttagagccgtttgatggagtagctttgt
				gaatctaataattgaggcttacattttgtatgtctttatttttctcataatttatttttattttataaacatgtctgtttgcaactcattagaactttaaaaaaaaaaactagt
				cattcactctaggtagagtagaagtactgactatgaaggatctttaaaggtcaatagtggtcctaatacgtaaaataatttgctcatatggtgtatttaaactattg
				gcaactatgtaaaagggggaatgggttgaccttcatgttacaaatattaatttctcctgcataaaagtaccctcattg
1504	3653150	—	NO	tttcatgagatctacacctgggctgggcacgcctgttggttttttactgacaacgcataatttttcgaggagtggtaatcagaggcaaccgttctagtgacagtg
				attcaggcgtaaacacttggctttggcccagaggttgcactgtgtgagaccacaggtgaacactagaatgtttacactcttccggagtctgtaggtggatgcca
1505	4011856	IL2RG	NO	cagggtcctgtagccctaagtggtactaactttccttcattcaacccacctgcgtctcatactcacctcaccccactgtggctgatttggaattttgtgcccccat
				gtaagcaccccttcatttggcattccccacttgagaattacccttttgccccgaacatgtttttcttctccctcagtctggcccttccttttcgcaggattcttcctcc
				ctccctctttccctcccttcctctttccatctaccctccgattgttcctgaaccgatgagaaataaagtt
1506	2351151	—	NO	aaatagctgggtctcagtgtctcttt
1507	2577491	—	NO	gttctccctagttttctctacaacagtggaaaacaaagcagtgctctctatgccaggacagtacatttggacggcgacaccttgtttgcagaatcct
1508	2693258	—	NO	atctacattttcacactgacaccca
1509	3156385	—	NO	agtcacacccttggggatctcattgtgtttcatgacttaattatgctgctgactctcagattgttatcttagtttttcagacttctttcttgaactccagacccgtggcc
				actatgttctcgccatgtggaatctgatgtctcataagcatttcagacttaatatactcaaaaggaactgatattcacgccaagcctgcttctctccccttctccact
				cactaaatggcactactttccttctggctgg
1510	3175668	VPS13A	YES	cttggaggtattatagcagaagtgaatttggccgagcattctacagttattacatttttagattatcatgatggagcagctacattcctcttaataaatcacacaaa
				gaatgaacttgttc
1511	2389740	—	NO	atgagtgattcattctgccctgtggacacttgggaacagaaggcgactcttgagctgggttttccaggcttattaggcgctcagtgggttaacagaatgagctg
				gtccaggaagagatcagcctgtgaaagccgtggctgggatattattggagat
1512	3224499	—	NO	atctcttaggtcatatgtcatcgcattacctttaaaaattgtatggtctaaatgtaaaatagttatttttcaacatttgttttaatacccttgtaactgctttttactcaaga
				cagacatttcacttacactaagtgtgtgtgtgtgtgtgtgtgtgtgtagaaacttaggatataacacgtatgtaaattacacacacatacctgtttaaatgtaagaa
				ttcagtgataggaacagttcatctaagaagattttaatgacagggcactcttttggccaaagcagtggaatttcctaagcagcaaggttggtaatagtgctggta
				ggatctgtatgtgtaagctgttacacaagctgaggatcaaagtgccaatttctcaaggagaaaaacttctccgagaaatgaaagtctctgatctgtgttgtatgc
				cctaa
1513	2807754	C7	NO	gggccagaacacactctacaaaatgactaggataacagaaagaacgtgatctcctgattagagagggtggttttcctcaatggaaccaaatataaagagga
				cttgaacaaaaatgacagatacaaactatttctatcctgagtagtaatctcacacttcatcctatagagtcaaccaccacagataggaattccttattctttttttaat
				ttttttaagacagagtctcactttgttgcccaggctggagcgcagtggggtgatctcatctccctgcaacctccgcctcctgggttcaagcgattcttgtgcctc
				agcttcccaagcagctgggattacaggtgcccgccaccacgcccagctaatttttgcatttttagtagagatggggtttcaccatgttggccacgctcgtctcc
				aactcctgacctcaggtaatccgcctgccttggcctcccaaagtgctgggattacagacatgaaccaccacgcctggctggaatacttactcttgtcgggag
				attgaaccactaaaatgttagagcagaattcattatgctgtggtcacaggggtgtcttgtctgagaacaaatacaattcagtcttctctttggggttttagtatgtgt
				caaacataggactggaagtttgcccctgttcttttttcttttgaaagaacatcagttcatgcctgaggcatgagtgactgtgcatttgagaatagttttccctattct
				gtggatacagtcccagagttttcagggagtacacaggtagattagtttgaagcattgaccttttatttattccttatttctctttcatcaaaacaaaacagcagctgt
				gggaggagaaatgagagggcttaaatgaaatttaaaataagctatattatacaaatactatctctgtattgttctgaccctggtaa
1514	3929304	C21orf59	NO	tccacacagtgagagtccagggctcagggctgctcaagaccaaggcttcccttgatgcttcacttcgggtgatcagacatgggggacctgtttatctttagta
				gccggcaaaggcaatcgtaaaacatttgttgtaacttcaggattgtcactctaagaacacc
1515	3947636	TSPO	YES	gtacggctcctacctggtctggaaa
1516	2748234	—	NO	cgaggtttatgttgtgttaggctcatgagaaggcaagaaattttattatttaaatgttttctccagtaatgtattggattcaagccattgagatttggggagtgtttca
				gtgacttatttgggcaaaacagaatatttgaaattggcattgtctcagaatctggc
1517	3630746	ITGA11	NO	gactgtaaatacgaacccaatctgcacactccaggcctctagttccagaaggatccaagacaaaacagatctgaattctgcccttttctctcacccatcccacc
				cctccattggctcccaagtcacacccactcccttccccatagataggcccctggggctcccgaagaatgaacccaagagcaagggcttgatggtgacagct
				gcaagccagggatgaagaaagactctgagatgtggagactgatggccaggcaagtgggaccaggatactggacgctgtcctgagatgagaggtagccg
				ggctctgcacccacgtgcattcacattgaccgcaactc
1518	3004500	—	NO	ctcatgcttcaaaggcatattctcaagaaacaggtgtaatttgtgcagataatcacacctgggaagggatcacagagaaggagaaaaagaaagaaatggct
				tattctgaggtgaatgtgtc
1519	3552925	DYNC1H1	YES	tgccaccttgatgacgcagtgcaaagagggggcacagaaggaaggcctgatgctggactcgcacgaggagctctacaagtggttcactagccaggttat
				ccgcaacctccacgtcgtgttcaccatgaacccgtcctcggagggactcaaggaccgggcagctacatcacc
1520	3649810	—	NO	cagcaagaggtgcaggttgagtatttggaggtggtatatttggccagactttagccgcatcgattatgctatttcttgctggctgttttaaattttttttaaaaagga
				ggaggtgtcagatacatcatttca
1521	2782685	—	NO	aaaactagggctgtccaggcttaca
1522	3166121	—	NO	caaaagcctgctgctgggtagatag
1523	2524769	—	NO	agtgtagtgcagcattgcctctggaactggcctgattcttgcctcataaaattcttgtgaccaataaatgaaattctacacatttttatgtgtctaaaatcccaagac
				tagtatctgacacatggttagctctcaatatattttagctactgctattatcattattggtagtactattaaacattttgaaacagaaaatcacttggggctggtcacg
				gtggcacacgcctgtaatcctagcatgtggagaggccgaggcaggtggatcactggagctcaggagttcaagaccagcctgaccaaatggtaaaatcctg
				tctctaccaaaaaaatacaaaacttagatgggcgtgatggcatgcccctgtagtcccagctactcaacagggtggggtaaa
1524	3101675	ADHFE1	NO	ttaactgaaagaattaccgctggccattgtagtgctgagagcaagagctgatctagctagggctttgtcttttcatctttgcgcataacttacctgttaccagtata
				ggtgggatatacatttatcttgcaggaaattccccaaagctcagagtccagttccttccataaaacaggctggacaaatgaccactatgttagacccccaggc
				tcgacttcaggggtcagtgttcctgtcccaaaccccacacagaatactctgcctctgtttcatgtagcaaatga
1525	3633418	SIN3A	YES	cacctctcacttgcgtatgaagacaaacaaatactggaagatgctgctgctctgattatccaccatgtgaagaggcagacaggcattcagaaggaggacaa
				atataagataaaacaaatcatgcatcattttattccagatttgctctttgcccaaagaggtgatctctcagatgtggaggaagaggaagaagaagagatggatg
				tagatgaagccacaggggcagttaagaagcacaatggtgttgggggcagtccccctaagtccaagttactgtttagtaacacagcagctcaaaaattaaga
				ggaatggatgaagtatacaacctcttctatgtcaacaacaactggtatatttttatgcgactgcaccagattctctgcctgaggctgctacggatttgttcccaag
				ccgaacggcaaattgaagaagaaaaccgagagagagaatgggaacgggaagtgctgggcataaagcgagacaagagtgacagccctgccattcagct
				acgtctcaaaga
1526	3904327	—	NO	ttccaaaggtcgctaaagatactgttactactattgagatattattggctacttcacgtttacatagtaaatgtttgcagcatataacattacagactcataaaccca
				taattaacttataagtgttaatggacaactgtgctttgatttttgcctttagtgataagaaaacaaagtagtgaaatgggtcactcctcaaagcatggaacattttaa
				ctttgcctagtaaggaaaaacaaaacaaaatatagcaattacatgtggaaccgtaacctgcaaaagtaacacaaatattgtctcaaaaggtacaaataggttgt
				acctggaccttaagcagcatg
1527	2652509	FNDC3B	YES	gcaccaattgacaacggttcaaaaatcaccaactaccttttagagtgg
1528	2441680	—	NO	aggcaagagccctttcgtgcaagtaagcaattttgctgcctcccattttttttttttttttcaatctgtttgggactttgagggctggggtgggaaggtagtggaatg
				gaatagataaacagccagtcaagagctgtggggaggttgacagaattggggtgcaggtacatgtaggatacacagaagctttgtgtctgtggaggctgtat
				gagtctgtgggtgagcagcatgtctaagtgggtggaaa
1529	2694895	—	NO	atgccttggagacgagcccagaaggag
1530	3048170	C7orf44	NO	tcctatcatagctggcaccgtgttcatgcctgtggtattccctgtatccctattcctgggaagcagcccaggagggggattcccttggcctctccagggtcagg
				tcacctttcccttcattagtgtgatgggaccttcagaagagaagcactttctgcggccaaactg
1531	3085948	—	YES	gaggccggtagtgctgaatggacatggggctggatgaaaagacttccgcctgcctctctcagccccggaatcgccatgagctgctatt
1532	3300246	CPEB3	NO	ggcctttccttggtgtgacacttgaactagtcgattttttgaaggctataacctaacctcgactatttgttgttatgtgca
1533	3822344	MGC3207	NO	ttggagacaccatgttagtcgtggctggtctccaactcctgacctcgggtgatccgcgccccgcggcct
1534	2345520	—	NO	aagcctgtttgagagcaggactgat
1535	2549493	—	NO	gctccggccgagagaagccaccattcctttc
1536	2788417	ZNF827	YES	gaagagttactggaagcggcacatggtgattcacacaggtttaaaaagtcatcagtgtccgctctgtccattccggtgtgctcgcaaggacaatctc
1537	2544515	ADCY3	YES	actatgtgaccttcatggtgggggag
1538	3329911	NDUFS3	YES	ccactgtcagaccacggaatgatgtggcccacaagcagctctcagcttttggagagtatgtggctgaaatcttgcccaa
1539	3467685	—	NO	cagggagctgcatgtccaactgttctcaggggagaaagtttggccttctctaggaacagacggagagaaggcaagggatcctaagggagatggtgcaag
				ggcttttggggagtttggggtttatccaaaatgtagtagagaagagggttcttgaagagttttcagcagggatgggacatgtgggatttgtgtaaagcaggga
				gcaaactatggctcaagggcctgctttggctcactgcctgtttttggaaacaaagttttattggatcacagacacaccattagttttcttaggagctacaaaggc
1540	2535364	—	NO	atcaaggaagtcgagtaaaacacttct
1541	2979944	SYNE1	YES	gcagcaaataggtgaaagattgaatgaatgggcagtcttcagtgaaaagaacaaggaactctgtgagtggttgactcaaa
1542	3210881	—	NO	atggctctacagcaccggattttgcatcagaatccttcgagtttcttatcttcaccatctgtagcatttagattgaaaaggcttacctgggttttctttttttgtgtttt
				atgatctcaagctattgggagtagaccaattcgtgtggctcaatatgagagttaaagttacgtcagaaggtaatgaaagctgattttgcccttttattaactatagt
				attttaatcctggtatgtaaaattattactcatttgtgcctaatgcagataatgggaagcagctcactgtggtaaagtaggggcattaagcacaggtgcaac
1543	3984493	—	NO	ccagggaaatatgggaactgtgagaggcagcaggcaagttatgggcagaggcagatacaatgagttcatgtgggaaattt
1544	3294206	—	NO	ttttttctgcactcccattgcttta
1545	2389550	—	NO	atgtattggtggacagcatctaggaagaga
1546	2593736	—	NO	gctgtaacactttactatgtctatgcaaatacacatttaaacaatataggaagatttcaataaccaaactaactgtacaaaaaataaacaaattaactttattacatt
				gctacttcaacttcagtccttacattgatttgttttttaaaaaataccagtttgaaacacattactgaaagtgagtgtacacaataaatagaaaatagggatgcata
				gtgctggagacattcaaccaacttatcttcatctgttgcctactgttg
1547	3315642	ATHL1	YES	gaatgcagacgggtcaggcgctgtgaacttcct
1548	2638195	—	NO	gtcaacgaggggaatccactctgcc
1549	3973655	—	NO	cagtttggcaaagagcatgccactgttcctgctgtctatcaaag
1550	2409486	—	NO	tctgaaatccgacatcccagtgtccattctggggcacagcttcccctcctttcaagtctctctcttcctccctctccacaacacagaggcctttagctccccagc
				ccttactgttcagtgcgtccacccctccttgtctagaccctgaagtatattacatcagctactctcttgtgagctcctccagtactctgccccttgtccttctattgcc
				ctagtctagg
1551	2635963	PHLDB2	YES	cctgcctgtccggaaggaagactttgatttgcggagccatgtagagactgctggccacaatattgacacctgttaccatgtatcaatcacagagaagacctgc
				cgaggattcctcatcaaaatgggtgggaaaattaaaacgtggaaaaaacgttggtttgtttttgatcggaacaagcgaacattctc
1552	3730508	TANC2	YES	tccacaatgttgctgccttgctctgccgctcacctcagctgacagcctatcgggagcagcttctcgggaacctcacctgcagagcatgctgagccttcgttc
				ctgtgttca
1553	2512118	—	NO	ggcatatgtttggtatctctggtccttagttcctgaacaattctgggctaatgctgtagtca
1554	3181032	—	NO	tgcttctaacaaatccgccctgtcacatgcatatgctttctcaacattcactgtcaaaaatgccctaccaggacacaacatagtgacaataacacattcaatttaa
				ggataatggttgagagggaaccagctaagaacttacaata
1555	2401404	ASAP3	NO	aggcctctggatggcagaaggaaag
1556	2496802	MAP4K4	YES	tgatctttggtcttgtggcattacagccattgagatggca
1557	3048180	—	NO	tcagatttactttcccggagtagtcacaggactgggcagtga
1558	3436406	—	NO	ctctgtgccttatcaggagagggtgactctgtgccgactttacaaggctatgggaaggacac
1559	3840203	LOC400713	YES	gctgtcgtagagtggcaatcatcagtggc
1560	2633650	NIT2	YES	ctggctgaaatacgccagcaaatccccgtttttagacagaagcgatcagacctctatg
1561	2835873	—	NO	tgatcaaatagtgccgtctgcctggagtacagcatgggggaagaggtttggctgtgttttgatgtagtcactgcccatagtgttgtagttgcttcattttgatgtgt
				catacagctaaagatgctccctttaggtcatttttgttgccgctgcctctgcggcttgttactactgtt
1562	2849540	—	NO	agaagacaagaggaagccgttctgctggcatttcgtcgggatgaagacaacacagcca
1563	2986834	—	NO	ctggccgtgtttcctgtgagttttgagg
1564	3222790	—	NO	tgctgttctgcttctcccattcttgcatagagtaatggagttagtgaaaatgggctttcttttacaacacaaagtgttgctcttctttctcctagggagaaagtagta
				agctctgtgggtgtaggaggaggaaaatagcaggagcttagccaaggagggtgctgcagcacatgtgggtcttcatagtccggaagggtgagtgacac
1565	3317133	—	NO	ccaaaaggactgtcgtggcagagcagccatggccaagtggactcagggttcattttcggaacccctttaagcttatagaaagtccccatcatcacccagctc
				ggccccggggcaccgagtccgtctggtgtggggcgtcctttcgacagagcctcctccacaaacccagactctggcttccaccagggccccggacacctg
				cttcctcagggcagacagagaggggtgacacactgcaccctgtggctgggaaaaggggcctgggactgtgcccgtctgggacggagcagagccacca
				tcccatgcaggcactatcaccgcaggcaaa
1566	3600340	—	NO	agggccactcaaccatgcgctctgggaggagtgggctgagatggggctgcttggtcagccctgactgtgttttgatctttgggcgtcacc
1567	3929187	—	NO	ctggccaccagggaacagttacgtaaattatttgatgtgtctttttaacaagatattaggaagtgctcggcattgttaggattttttttggccacgtggaaaaacac
				acatgatataaagcaaaggaaaataaggcagtctgcaaatggatctgcttagaactgccattacgtaa
1568	3989061	—	NO	cttgctctgtcataccttgtggaaatgtaaaagatcaatgacagctagcctttcacacaattatttatgcctcggccctctaattgacacagttacccctagcact
				catcgttgtgatcacctgcagccaagacgctgattttctgctcctatagcctggcaaccttgtggtacatgggactacgtccttta
1569	2735839	MGC48628	NO	tatacatatgtctgcctctaataaa
1570	3660480	—	NO	tgagaccgcaattccagcacgcattggcaggacct
1571	2655657	—	NO	tgggaggaggacgtctttgggattccttctcttcatgagctgc
1572	2848543	—	NO	agcataaagaaagttggcctgggttttcgtgactcggcagggtccactcagtttaaaatgc
1573	3397172	—	NO	ctgccgtgggcccattgaccagagcgacctgctgtctgatgcc
1574	3790842	—	NO	atgtggcgaatgggtagaagaatgt
1575	2824108	—	NO	ttttctgattcactaccactgctggtgttacagcgtgaacgtgacctgaagacaa
1576	3361136	—	NO	agaagcaggtataagccaaatgttgagagttagagaatgccagcctgcagttgtcatcacccaggcttagtacc
1577	3971846	—	NO	atgttcactcaggctccttggtgtg
1578	3294447	ANXA7	YES	gtgagttttccggatatgtagaaagtgg
1579	3850170	S1PR2	NO	gttgcactatttggggcacagaataatcaccaaaagtgagaaaaacgagtttgggtggctggggaggactttgggactcttgatgcaaggcgcaacttgag
				aaaattctgggtgtgatatttgcacagacaccctcctttcaaaaacagccaccccccaagctattctcagctccacacctgcagccccagctaaggtaccag
				gtctcctgagcaaggcagagagaagccttgagccttctctgtgtcttctttcaagaaccccgctgtgtcttctttcaagattttttttttgagacagtttcaagattttt
				gttttgtttttgagatggagtctcactgtgtcacccaggctgaggtggcagtggttcaatctccgttcactgccacctccacctcccgggttcaagcgattctcct
				gcttcagcctctcgagtagctgggactacaggcacctgccaccatgtctggctaatttttgtatttttagtagagacagggtttcactacgttggccaggctggt
				ctcaaactcctgacctcaagtgatccgcccgcctcggcctccccaattgctgggattacaggcgtgagccactgtgcccggccttcttctttcaagttatatag
				aatggagcatgggggtggcagtggctagggacatttcctggggacactctcccctaaccccccagaaggacttcacaaaaacctgtggataatggaaggg
				atgttacggtacaaacgtatatttatgtgtgtgtgtgtgtatgtgtgtgcgcgcgcgcgtgtgcacataggcgtgatgtctgtgaccctc
1580	3918219	—	NO	tgcggattcgtctgctccacgcagggtgctctgacgtactctgtgtggcctggagctcagaaacctgtgctggactcagtg
1581	2370552	—	NO	gttggggtgaactgaacctgtccattt
1582	3476124	—	NO	gagcgggatcgaggcgtttttaataattcgagttgggaagacccggatggttcatcaaaatgatggtgttgagcacccgggaggcagacattgggtatttgtt
				cacaattttgcacctgtaagaaaatgttcctttataactttcaaggattgccgtgagcgtctttggggccttttcattcatgtacaagtttcattcattactattcaactt
				ggtagacttggtgaaaaatgtaaaagcattctgtatttggatcagtcttgggaactaaatttgtcgtgaattggggcctgtcacagattgcctccagtgtgcatcc
				tccacgcagaccctccttgctcagtctccctctggcgcccatggggaagccgtgctgtggttggcagtgcggccatctgggctgccgcaacgtggcaggg
				caccgtccagcaagactgccccttagtgcagggctaagcaaggaaaagaagaagcccaaaaaggcgggttctttttgatacttgtaattcaggcgtcctcc
				agagtg
1583	3929424	C21orf66	NO	ctgttgctgattttggtgacacatctctgttgatatcagtaaatatcaattgataagtaaaaaaatatgcaagtcttaacttggatgtatttcatcttgcatgtgctcac
				ctccctcccctctcacccagtcgtttgggttgtttgcctccccttactgtcatatcttcatagtgtggaactaaaacgtagaaatgagggaagtatagtggacag
				atgtttcccccaccccttcttttacctaggcaagagattaggggagtcttttttgattaaagagagtaggtccaaaataaagaccctgaaacactaaaatctggg
				gatccccaacaaaagaactggctcagtacctagtgatccgacggagacacctctgttagacagctcctgcccacacacacagcttccagtcttgctatctat
				atgaacaggcagttaacgatgatcataaggaccaacctgagcagcagaaccaaagggactgaggaaacagacagtgctggtacaagtatgcaagttttct
				gtaaacagattactttcaaacagttgggagccccagggagataatagaaggtatcctactcaacaggagtatatagaatgctgtagaagaggaatattgtaa
				gaacaagaactatctcttgaaaactaaaaatatgataactgaaatataaatttaaataggattggaagctaaagctaggaaattaccctagaatgttttagagaa
				atggaaaatacgaagaccaaaaaaataaaataaaactatgctgtgaaagagaaagattagcatttgagaaggcggaagttggtcctgctcagatgcggtttt
				cagatgcc
1584	2418445	—	NO	aggtttcaacccaactggacctgcttg
1585	2977983	EPM2A	YES	aattctaccaaatatctggctgggtag
1586	3074397	CNOT4	YES	ttcatccaatcacagtgcacggtccccttttgaaggggcagtaacagagtcacagtcgttattctcagacaattttcgccatcccaaccctatcccaagtgggc
				ttcctcctttccccagctccccacagacatccagtgactggcctacagcaccagaa
1587	3320669	USP47	NO	cggtggagcctcatgatctcttatcttttgaggctgaggcaggtcacatgcaacaaattgtgaccctgctccccacaagtcatgcaaaggttttgaagagctttt
				accgtggggcagatgaacttgtgtcaaccatgcacaccctgtgagaaccaagtacctgtgtttctaaggcgggcactcaaggtgaggggtgcattctggcc
				aaagaaacaaaagctgtggtttcaggaccatgccgtgtgtagctgatctgtacgggacgtgtatgtaaggaagagcaatcatgatagataagaacagtgtgt
				gaagcagccttcacactagagtgtttggtcatctcttataatgtaagggaaggtactttaaaattctgggaagatgcgatgaactcatgtcccagtcagaaaata
				atccaatgaaataagcattggttgccaggccacagttaggaattgta
1588	3562057	—	NO	gagcaaaaatattgtcaggtttcttgctgtggttctggatgttcagtagcaggctcatttg
1589	3924690	DIP2A	YES	gggcctcgtggagcattcgtactttgagcgtccacaggtggcttctgtgaga
1590	3029146	—	NO	agtcaactcggggagtcaaattaggaaaggcttcgaaggatgggcaggacgtaagaatccagagaggagagggatgtttggagaacagaaagtggaag
				gttcctgtaggaaaatgatagagctatacttggagaggcaagcggggc
1591	2480430	—	NO	tcttcactgaaggtgccagcctatgggtggactcgtgatctagacctaaagggttagtgtgagttcctagaggaaaagaaagccatgaggcagattgtggaa
				ggctttgaaggccaggtggagggccttgaactttattccatagacaatggggagctattga
1592	2923442	—	NO	ctgggaagaacttcaggctgttgttcagggcatggatatcaccactgtcca
1593	3393487	FXYD6	YES	cctctggaacctgaggcggctgcttgaacctttggatgcaaatgtcgatgcttaa
1594	3879288	—	NO	gctttcaagaatacggccatgtctgcattgttggcttacacgcagacacacgctcgggtttttcatttggcagggtg
1595	2889490	AGXT2L2	NO	catctcatccaaatacacgctattgagaaggcgagcctgacctccctcttacagataaagtcagctttcagaggctcagggtgggggggcctgcccgaggc
				cataatgctacccaccccctcctcctaaccactggtctgttggaataaccca
1596	2915334	DOPEY1	YES	agattggttgagagtctccgtttgccacaggtgccaactctccattctcaagtgttcctgtttttcagagtgttacttttaagaatgtctccccaacatcttacctcac
				tctggcctaccatgattacagaactt
1597	3186622	—	NO	ctcatattaggatgtggacctgtccaaatcttcagggagtcctccctccccaggccaggcaatttctccagcaccaaggtaaccactgttttgttctctattgcta
				tggattggttttgcttatttgtaaatttatttgtagacttggtccctatcactacgaattggttttgcttatttgtaaacttcatataattagaaatcatgaggcattttcat
				aagtgtgttttcaacttctataaagagaaacacaatgtaccttcttttttgtgtcctaaaccttctttttctcagtccccttccctgtacatgcacttttcaaagtgatta
				gaggtacagagaactcttcctctaatctaataaacaaaatgatacaaactcaataataggtggaaatgcccctcaggttcaatgctagagagaaactgcagg
				gaatggtggggactatggcaaactatggaaa
1598	3720992	—	NO	catttctatggttattcgtggaatgactctttgaccacgcggagaaggcaaaacttcagccatttgtgtttttttccccttggccttcccccctttcccaggaagtcc
				gacttgttca
1599	3916840	—	NO	tggcaatttcaacagttcgtcactgcacgctgcctcttaaagg
1600	3959370	—	NO	catgggcttctcagatccaggtgatgccca
1601	2571999	SLC35F5	YES	tggtttcactcagcgcaggcgaatggctcttgggattgttattatctgcttgttgatgtgatatgggttgcttcctctgaacttacttcg
1602	3757901	—	NO	tatttccttattacatgttccagacaggagtgctagccca
1603	4002896	—	NO	ctttcatggagcaccgctgctcacgacctgttacagtctagaaaaatggaaaaactgaaaatgggtatctatgccacctaa
1604	4013965	—	NO	aaaatctactgtggagggagtgcaaa
1605	2327098	—	NO	atacttgagagtaaatgaactgctcttgttactttactatgtcaattacaaagcttaaaattcacacaagccacacgacatatttaagaatgcatgtgagggcca
				ggtgc
1606	2381607	—	NO	gacatcagagtggaacttgggcgatgctgccaacatga
1607	2995272	C7orf41	NO	cactcccgcttcagtggggtttctatggagttgtcttggtagcctttgccattttgaatttagagtccattttgtggctgactattctcttaagtttatgttggagaatta
				acattcgctgactcgaatgtagagaactctgaatgtattaaggataggttttgagtcctcacaggtgaccttactgagggaaagcatggcagagaagaaatgc
				agtctgcactttttatgtactttttaagtgtccgtaagtgaaaggttttgcttataaagcatgaattttaatatctagtcattaaactgcacaagtgcaaatacaaggg
				caggaaaggataatcacttagctttggactaagagggtaagagaggcccagaagcctttaagtgttttgccattactgagttacctgggtatgtagcgactgg
				ttc
1608	3261789	SUFU	YES	gctccaacctgagtggtgtcagtgccaagtgtgcctgggatgacctgagccggccccccgaggatgacgaggacagccggagcatctgcatcggcaca
				cagcc
1609	3934119	SIK1	NO	tgtgcgcgtgcattgattactatccatttctttagtcaacgctctccacttcctgatttctgctttaaggaaaactgtgaactttctgcttcatgtatcagttttaaagca
				gcccaggcaaagatcatctacagattctaggaattctctcccctgaaatcaaaacctggaagacttttttttcttattttagttgagaagtttcataaactgctcaag
				gattagttttccaggactctgcggaggaacggcaggaagaacctcagagagggcagaggtgacttcaaagtgctggggactccgtcctgagggtcacttg
				gccctgagcccctgcgtgcccttgcggaagcccagaagcttcttcctgctgcacctcccgtttccgctgctgctgacgtttatgcatttcatgatggggtccaa
				caagaacacctgacttgggtgaagttgtgcaatattggaggctgactgtagggctgggcagctgggagacaggctcatggctcatggctcatggctcagg
				gcggtgcctgccctgggccgggacccccctccccaccccccacctaggctttttgggttttgttcaaggaaggtaaagtgagaggtttaggtcagtgttttta
				agtttttgttttttttttaaagcaaatcctgtatatgtatctacatgggagacaggtagacactacttatttgttacattttgtactatacgtttgtgttccaggtttcagct
				tccctcgctcctgttgttaagaagcgtccctgtcagcacaggtgtgcattgaggaaggggccccagggccttcgctccctcagcactggggtggaggcgg
				caggaaggggcggcccttacctggcaggtctgggcgcacctttagcaggtggactccgtggggctccaccagccagaagcctctggaaggcaacgaag
				gcaatgctgctccctgagtccagtccccgcccccaaacccagcccaggtgccttcagctacttcggcttcttaaaccctgcagtgtt
1610	2748304	—	NO	actcaaggtctgtccatgctggtgacttagagtagtgggatttaaaccagaggatgcacacttggaggcacttgaagatgtttcaagggacatgcaggcattg
				aatatttaaaggaaattaattgccgattcttagatcttgagtgttaatcagttctaacactgaccgtcctgagaaaatgcctatggcccaggtgacctgctggtttt
				cctttcacaccttctctttcatgattaccattctttaaagggaagacatacctttcacctaccccttatcagagtgccaagtagggggataattaaaatactgctgg
				ggctgctgggaaagtgagtgactcta
1611	2358329	TARS2	YES	ctccagcacccatgtcctgggggcagcagctgaacaattcctaggtgctgttctctgca
1612	2636804	—	NO	tcttatcacaacactgcggcgggaaaatcaggaaatgggttcacctttcagcagtcaccacagtaaacttcattgagaacatacatgcccagatatctcttctg
				tgcacatgtatatgttaacagctagccattcagccaacaggta
1613	2907584	KLHDC3	NO	cagggaagtcactaatgggagagtgggaggtatttgaaaagggggtttcgtgggtagtttttgtcctactttcatctctcttttgatcccgacag
1614	3185561	—	NO	gcgagtcgactcacctacctcttttcaagccggcctagccccttcccggaacctcggctcccccccaacgaaactactgctaagccaactggactacacttcc
1615	3752751	—	NO	atgggttcaagacctgtttatgtgcgagaacaacaggctttggtgctggtgactcaccaagatgggaaatacaggaaaagaagcagggatgtggtagcag
				agtgt
1616	2366872	—	NO	ttcccatccctgctctagcagcctg
1617	2389086	—	NO	tgagagaggtttctattgttcactttagaaaaatgtaggtcaatgtaatgggtgatatctgttcttaattattctaagaattaaatcctgtatgttatcagtcacctatta
				tatggcacaccctcagggg
1618	2523976	—	NO	aggcaaggggtaaagtccaggatgaggc
1619	3394423	THY1	YES	gcagttcacccatccagtacgagttcagcctgacccgtgagacaaagaagcacgtgctctttggcactgtgggggtgcctgagcacacataccgctcccg
				aaccaacttcaccagcaaataca
1620	3510096	POSTN	YES	agggagaaacggtgcgattcacatattccgcgagatcatcaagccagcagagaaatccctccatgaaaagtt
1621	2974447	—	NO	atggattacgggcttttatgtgggcagcaacttgtgcctcag
1622	3000375	—	NO	gtcacttttgtggcctcttggctgtaccttccctgggacaggacacggtcctttct
1623	3498077	—	NO	gcagttatgtatacacagggcaatcatcagaccataatcattactgttcgaggccagaacagagacgactagctctctgtgtgcctttcccaagtctcaccgtg
				atggactgtcctctc
1624	3670758	—	NO	gtcttcagagctagccggctgtgtcttctccccgtttctttcactggtgaataacctttcgtttgaaccagccttgattgttctctccatgttccactgtggctcccca
				tggacactgctaggtggaatctctgagaaaacaggcacttcgcagtcggcgcatctttctctgccagcttagggattgccgtcaaggtggaggaagggtatt
				ttggccatgttcggagtcgttgttttta
1625	3418194	—	NO	cagttagctgtagagatgtgatttagcaaagttggttataaagtgggtttttgtaaattgatttccttattactgttctttgtagaattgaagatgtattctctcccagcaa
				aatagttcacctgcagatcattgaaaagtttggctgaagaaaggggttattttggtgtgggggtaggaggcttctgtgggctgggcatggtggcttacatttgt
				aatcccagcactttgggaggctgaggcaggaggatcacttgaggccgggagttcaagacttgcctgaccaacataatgaatctcccatctctacaaaaaga
				atcagccaggcgtggtggcgcacacctgtagtcccagccactcaggatgctgaggcgggatggtctcttgaacttgggagattgaggctgcagtggagca
				gtactcgtaccc
1626	3687863	ZNF764	YES	gaggtggcgaaatgtcagacacaaacggac
1627	2438168	—	NO	gggaatatagagaggctgctgagag
1628	3059966	KIAA1324L	YES	ggctctctgtaccaacaatataacagactttacagtaaaagaaatagtggcagggtcagatgattacacaaatttggtaggggcatttgtatgccagtcaacaa
				ttattccttctgaaagtaagggtttccgagcagccttatcatcacaatc
1629	3281916	—	NO	aaaaagtaaggtggatatgtgcagtggct
1630	2838994	—	NO	gtagaaaggggaatgtgtactgctagaggttacgggctttga
1631	2724513	UBE2K	NO	gtgtaccaagactagcaagagtttgcttcaggattttgttgaataattaagataatattttgagtgtgtcagggccattcaaattgttggtgttgcatcacagctac
				cttaactgatttttaacatggatcctctgtgcctgtgaatttacttgcatgcttgtacttgacttcttaggatgggtagctgaaaagaccaccattttaagcatttgaga
				attcttaaatatgaaatttattcagaattgaagatggtgacctattcagagcctttttgtccttgtcaacagactgggacagtgtctgattcccccttcacccccccc
				acccccgccttgccacacacagctaatattctaatggtaaatttctctgtatcaggtggggaaatgtgctgaaggacagtatgtatcccttgcttcatttttaggtc
				gtaggtttggaatgtcttgtcccagttcttcaaacactcttaaattttttcttaagtaatgtaaaaatggaactgccaattttatttctcttgcaaaaatagtaaatacttg
				atgttacattattcccaggtttaatgaaagaacccaacttagtttttcagtgaatttgacacctattttttagtgatgaaatttttctttgagaactggcaaggatgcag
				tcagctgtttgcagtttttagcctga
1632	2415597	—	NO	ccctgttaatcttgtggtcaccatacactcttgggttagctgtcaaattagggtttctccaccctgcttttgtataatgaagtttctaatcctaaatgcaggatgccc
				cattctgagcctgtttgtatttaacagaaaatagggattttcgtcccatttttatcttaccaattcactccccaactgtgccagaatgcccagaggtaatagcctttt
				ggaaggagctttcccatgctacattccagcagggtaaaacaatctgaaaatgttcttgccccttttatcactgagttctccatatcccaggctattttataaataga
				atttttccctacagaaaatatgtaaagccattgcgaagagaaaacttttctacacatagaaaacatgataatttctcattagttttggaacaatacaggtctactcta
				agttgtttcttattctggagtacaaaatttgcattttataatgtaaattgggacactgtatactagctttctc
1633	2818227	—	NO	cactatgtcaactgggtgtctttgctaagtttggcatcaatatggtgacctctcgggagcaggggaccactaggttacataaggaggggtgaactggcccag
				attggaaatggagcaggtcaaaactcccatgctaaccagtagtgagatggagcct
1634	3412324	IRAK4	NO	atatacacctatctcaaccatttttttaactgatttttttcctaaatattcttctttacctttaacaaggcataggctgttgcaggacagtggttattaaagcatgggttg
				aacttccaaaatata
1635	3598210	ANKDD1A	YES	gtcggggccatatggctgtgctgcagcgacttgtggacatcgggctggacct
1636	3728164	—	NO	cttgctaacgctcgccagagaaatattccgtggaggtgttaaaacaagactagtggaaagaaatggtaacttaaaaagaaagaaaatccatggcagtgaag
				aacagatttcatattagtactgtcataatattctctaatgtatcatataaataaaaatctgtttagaccagaattttaataagtcaccaaaggaaggttttgaatccta
				cagtttatgtatccccctttgcgatgtaaatgttcacatctcaagtgaagtagagtggggagacgcttcggagactagaggctgttaattagtgaggtatattttg
				atcagggcaagaagactggttcattctatatcttcgtatttctctggatgattatttcattttgtaaaatatgtaagagttcccccccagccccttatctttttaaaaatt
				aaaatggtcatgctcttctaaaaagatgacttaatttgaaggctttggagacatgaggatgatggggatccatcactccctgttctttgctccctttggactggag
				tgttggctgtctggaagagttttgcttgagctcgtgggttattttcttctatgtggaggaaccaagagactctttagcatctttcagcaagagcgaggtctgggtg
				tactcaccatctgtcttaattatccttgtgtataagaaaacattcccatcttttcccaattgccatttccttccttaacttttagaggccagaacctcatctgttgatgca
				gggagatctcacttctttaacctatttctagttgccttcagtcacagcggggtggccaggggcgagtcacttaagcctccccaaggctcagtttcctcctttgta
				aaagagggagaattatagtactcactgcctgcagttagttgtttggaggataaatgcaaaattcttcactgggagtctggcataaaacagcactccgcaaatgt
				ctgttgatcttattattatagaattattatttttattattattatttttaagacggagcctcact
1637	2779706	—	NO	acctggtaaagtgagaagagtgatcaggagaagataatttgcatagtatatatagatttctattccatttatataaaacccttgaatggtaccttagtagaaacaat
				ataaaataaagctaatatgggttagatgataatgtggttaagtggatttttttttcctgtctgaacaaaagaactgacaatttaatcaatagacccctgtcagtctgg
				agagatgcttctagtggtcagcacggcactctggtctttgtg
1638	3394582	—	NO	aacagctcaacatgtgtcgggatgtccagggaa
1639	2429120	TRIM33	YES	catattttgaaagcacggtgtgatcctgtccctgctgctaatggagcaatacgtttccattgtgatcccacctt
1640	3428756	—	NO	cagctaaggtaaatctgcttggtccaaacaaaacaaaacaaaacaaaacaccagactgcaacaataacaggaaaagatcctcttcagtgatttatgttgttct
				cttactttcataactagtttgaatgcaaggctggtaaagggatacacagagaatcattattttaaataacaaaagccattcaaaactctctctacctgtcaaggat
				gttttatgctcccattcttatttgtttggcagtaaacataccttgcccacagtcgccagcatcaaacccacaggacaagacattgcatgcttggtcacagaactta
				tcagcgagccaggaattcgcacatc
1641	3595186	—	NO	ttgtttaggcaaagcacgttatggctttttcttgcctagtttaggtctgtgcttaatgactactggaatagcagcaaacataacatcctgataacatttgggaggaa
				aagccatatttgaaaattggtgaaatgcaataatctttaaaccaggaatcatcagtttgctaataaaaggtatatggctccaagttacgtattttgtcagggtcctc
				tggcattttcactagtcattttgctagtgtgtacaatgattcctatcttgctgtaaaacttggtgatttttttatattgttgaactaggtgacatgaatattgagtcagatc
				acataatcttagagtaacacataagtgattatgtagcgttgtgggtggaaacaattctggataaaaagtgcatgacagttcagaactactgtgcaggcagcctg
				tctgaaatcaggtttaaaaattggccctgtctccagctgactcgttttgtc
1642	3959259	—	NO	ctcaagcacagtcatgattggttttgtattttcttctccaggctacataataattttttgacctggttttcttgatgccttataattctgaatgctggacttgtctctttatta
				cctgccagttagc
1643	2604457	—	NO	acagcaggaatctgtcagtgtccctga
1644	2843218	PRR7	NO	ggcgcgcgcacgacttgagacctgccacgggcagcccccggccgcgggtccccgagtgacgctggcggcacctgagagtgtggcgcgggcccggg
				gccacgcagcggagcccagtgtccagtgaagcgtctgaggacccgccgcc
1645	3039818	—	NO	gctgacctattgctgaggactatgagaaaaaagttattacagaatgagtcatatggaaaacacttgcaaac
1646	3483658	—	NO	gcagacaatccccatcagcttaaggttcccgtcaccagggtttcccttcatcgaaactttgccacagtca
1647	3605805	SCAND2	NO	tgtagtattcactactccagacctttttcaagttgaattttttttctttttccctatgtctgttcttacgtattttttttaaacttttatttcagtagtgtttggggaacaagtag
				tgtttggttgcatggaaaagttcttcagtggtgtttctgagttttggtgcacccatcacccaagggtagtcttttttatccatcaagtctgtacccaatgtgt
1648	3659197	—	NO	agagagcctagcctgaatatgccacagccgcacagagtttctcct
1649	3775146	—	NO	cagttaagtgcagctcggtgagtcccggcagttccttcccggcactggctcgtccctgggttctcaaggttccatgcggccacagcgtccgtccacctgtcc
				acgcgagccacatgctgaaatggaggtggataaaattcatcaggcagctgctgtaacacggaaatgtgcagatgccagagtagcttcgtc
1650	2534837	—	NO	tgtgcacgcatgcagcactgcgataacggggcagggggagttaggtgattgcttaaagcacaagtgtgtagggaagaaacaaaggcaggaggggccat
				taaggagcctgtagagtgtttgggtcgggggctcacatttgtacagagtgagctga
1651	2705269	—	NO	aaagctacaagcatggccgcctgtggtatcgaggtgttgcaaacaatatctgtgttgcgcttcctgttttaacctacctcgttttgtttgtttttgtttcactgttcatc
				acagcagtgttatctccaggagacatatagagagctcaaccggcaatctcaggtgcatttaacatttttaaaacgaaacagtagttgaccaatttttcttcttaa
				aaaattggaagtggggggaatccaatgacaaaaactaatgtggcttgtttctggagaaaataattactgtaaatggaacaacaacaacaaaaaaaactacga
				tcttactgactttgcctaaatacacaagcagctgatgtactattaatgagaacgaaatacacattaggaaaatggagccatttcaatctagtggtttgggcaaga
				tggggaagagaaggggaaacattctagtttctggattacattattatgcccctcctgaaaaggtggttgtcatttgcatttatttaaagcaggtaatatgcaggaa
				tgtaactgaggattatcttcaggcaatcagcaagatatcctcctcatggtccctttagctctcaaaagcaatgaaatcctcctgttctcatttttactgctgtggttgt
				gctgctgaacaatactatcttctcaaattccatgccacaaattcagcaataactttttggattgaatttaacaactactgtaattggatgctgatgtggacaaaatat
				attgatttcgatttcactcccgaatgtgattgccaccagctc
1652	3479382	GOLGA3	YES	tcagcaaacagcccgtgggaaaccaag
1653	2320890	—	NO	gtttcatgagacagcgatctgcctaaccattcactcctcctagaagcaaaagctaccgtgatcattgaggcacagccggtcttcatatatcctcaaaggaggg
				ggattagcttccacatcccttctctattcctggaggtgccagtagtgggagagtcatggcagaagttaccagaggcaagtggggcagaggcaagtagggta
				tatgtttggatcagtggatcagtgtcctttattgtgcagaaaaagctaaaattacagattcttctgaagggatacatagcagccgtttcaccaatgtccctcagtc
				catttgtccaggtccaga
1654	2824597	—	NO	tgtaggtgctgctttaatgcttggactgatgttattgttgtgggagtggattagttattgtgagcatgggttggttataaaagcaaggtcaaggctggg
1655	3916352	—	NO	taatgggcctgagtgtcaccaagag
1656	2900984	HLA-F	YES	ggaatgaatggctgcgacatggggcc
1657	3003162	GBAS	NO	ccctatgccgatgttgtcctggattaccttttttgtcctgtcttatcacttcgtctcctgtctcgggtttctggctgtctgttcctatttctatttgatgttgtgctctcactt
				cacacccagcatgtagaatcaccttgctcttccaacttccctgtctgtgccactcaccttgttttactcagcccgttccttagttctctgtggtgaatctgtcaccta
				agctgtgcattcttcatcggacatgtattttggttctcttgtttccttctccatctctctctccaagcctctcgagccccattcccaagtagcttttttttctgactaccttt
				ctgggctccaagctatacctgtgtctccttcctgccctgcaatacattaccccaaagtttgtcagattgatctgcttgagttctgttttcttttttcatcacgttttttcttt
				tctctgaaactttcagcagctccctgtttgcagaacataaagacttaactcctgcctggtttttaggggtcccaataatgggattctgcccaacccatccagttct
				gggtacaagtactgcctgccttacaatctccattcaggtaaggccagggctcctaagagcaggtttggggtccccagcaaagaggagtggctacaaatcca
				tgcgtgactttgtgttggtgaaaaacctgggccccgttgccaggcccctttctggaccccacctgaatcatgtgtactgggcttcctcctgggcactgcctcca
				atgcagggttgtctattcctgctcatgtcatgcgacgaaaaggaaatgttggacatacatttccctagcagaatccctctttccctgtcctcgattttcattgatcc
				catgttatttctgaacattcatgagtcacgcatcagatacatttaatatcagatcctaatttaaaaagtaaatgctactcttccaaaagtacacatgatgtggtcact
				atactgggtcataaagatgtatgggttttcagttagttagacttagaccgt
1658	3743421	—	NO	ggaacaggagaagccccaattttcagaagagaggggagttgattgagaagtgtaagattgttacttgagaataatcttgagggtatgaaggtagggtaagg
				gagaatggtgataaactc
1659	2949593	DOM3Z	YES	ctggcggcccagtcaccgtgtctgtacaccaagatgcaccttacgccttcctgccc
1660	3824798	MAST3	YES	acggcagaagatggtccctcgcgtctctcccatcttccggctatggaaccaacacac
1661	3933890	—	NO	tctccgtaaccctataacagtccgata
1662	3340811	—	NO	catttatttatgatcaaccagagagactaaacagtggactcatgggtttggactctattgcaattcaa
1663	3888249	DDX27	YES	gatgaagaactcaccaacacaagcaagaaggccct
1664	3932432	—	NO	atagggaatgtgctttgagctgttt
1665	3941419	—	NO	caggaaaagagttggcctggacctgca
1666	3976987	CCDC120	NO	gttgactgcgtgtccattgttgttatagttggttgaatctgtcccattaattctccttcc
1667	2892314	—	NO	acatggccagtactgtttcaggggaatattgggtggcgctgg
1668	3379157	—	NO	gggccagagaactttacaatgattatgaagatcaaagggcattagaatcaagctataaagagccactgtttgatgttgggatgtgaggatgctgcaggtggat
				gtctgcacgttgatggtgagaacatggtcaccctggccctgctgggtctttgctaaagagactgtgctctgttcttggggccgttttcatcacctgatta
1669	3830022	—	NO	aggacggtcggcgtgcagagttcctggagtgctggggggcctgagatggttgtatgacgtctggaggattcaggagggtgtatggggtctcaaggacac
1670	3904149	CPNE1	YES	ccttggttcagctgtccatttcctgtgaccatctcattgacaaggacatcggctccaagtctgacccactctgcgtccattttcaggatgtggg
1671	2408020	—	NO	tgaaccatccattgcctaaaactccagcaaccctaaaaggacccaatcaaccagaagaaaaaatactaatacctcatatcatacagcaacctaacatttcaaa
				gtgctttcacatgtgttagttcatgcacacctgacaacagtttaactgagggagccagggc
1672	2437930	MEX3A	NO	ccctgggtccagtagaatgtataaaagttgtaaggaaaagataaatagaggagggaagtggctgagtccaccctgagttgcccaatcttcagataccaggg
				ttggatcaggttgctagtttaagattgggagcttccagtctgctggggttgattctgagaatccttggatttttaaattgtaggacaaagaaatgaggggttcattt
				cccagggtcttggaaaggatgcacactgatcatctcaataagacaggggctgggttgggggcagcagaggaggccaagcacattcacctgcacccctag
				tacctgggcagcccatactccaatgtggta
1673	3264854	—	NO	ctccacctctttttgtgcgagggcggcctc
1674	2701275	—	NO	acttgctggaaaaagtacatgctctcc
1675	3017578	—	NO	tatctctgatggagctagtgaacattaagccctcaatatttgtttaatcagtgctatcaaagtggtttaaatggatgtagtctccaggggtctctg
1676	3625878	—	NO	ctacttcagtgagtgggactttagcctgagca
1677	2438152	—	NO	cagctccctgagatagatgtaaatcctaagcattgtgggtgttttggtttgatgggactggattgaaagatttacagacttaaattgtaaaggaaggtaatttaga
				gagaggaaggaaataaacattatgttggtttggttataaccactggcttgtctccactgacatggcctgggggtgagtggtgtatttgcaaagctcctttcaggt
				ctgcattaatctctggcattagttggctgtgaccgattagcctcccagttaaagtatgtagtcagttcttagtgatggtaaatgggttactgaggccttcttattaca
				tccaattatgaggtgactatataatttatcttgcaaactgttgagtgtgttctaaacagtatgctgtgggggcgctatcactaattatgctgga
1678	2786550	—	NO	gtacccaggaggtttggcatcactcaagaccctcagaatgcttcctctgctttaaatgcttggagtggctctctgtccaaactgtattaccccatccaaactaaat
				cacctctcactatgtggatgaagcaaacaacagatcttttgtttcgaaatgatttcatgttaactatattccaggatattaagatcttacttaaggaaactgctttgc
				agtgccagggatctaagctatata
1679	3122495	ANGPT2	YES	cagggacagccggcaaaataagcag
1680	3252241	—	NO	cttctccgcaccacatcgcccttactctaaaattgaccacataattggaagtaaaacactcctcagcacaagcaaaataata
1681	2806568	—	NO	agagcactcaattcgactatccgtccagctttcacagaatttacttctgagcccacaagactcaaattgtataaggatagagtctgtttcattcatcaacatatcc
				agcacctgacatagttttacatggcacagagtgggtgttcaataaatatttgtcaatgattgaacagaaattttcagcaccaaatgaaagaaacacatgactttg
				aacaacggcacgagaataccaactgtttgattatgcaacgacaggatcttttggc
1682	3385452	—	NO	agttcctaaatgggaacactgccttatgga
1683	3968192	—	NO	gatcaacgcttaattcaaaaccaggctgtagaagaagaagaagaagagctaagaaggttcttagtgctgatggggagaagagaaggttctggagctgtgc
				catccccgggtggaaagagggaatgtgttctttcttcccttgacacttctgtgcagatgaatcaggcaggaatcaagagcggttg
1684	2397794	—	NO	cttctgatcaccaagccacatgtgatgactcctgggcccttcttcctgggacaactgcaccagcttctaatcagctcgcccatctcagcctgacccctctctgc
				agcctgaagtccagactctctagcctggcaccatagtcctttccttctctctgacctaatcattaaccataaccc
1685	2412877	ZCCHC11	YES	cgatgtgacattggggatgcttccaggggaagtttatcttcatatg
1686	2904959	MAPK13	YES	gtgggctgtatcatggcagagatgct
1687	3367083	—	NO	acagactgacagaggtgcatggtggag
1688	2762520	—	NO	tttaccatcgtttcattccatccatcc
1689	3463535	—	NO	tgcctgtagctccatacctgtataatcaacagctattaaatatctgctaagcaaactaaactaagcattttcaaaagtaaacttgtgaaacctgatggatttcagta
				gttgacatcagcatctacttttgctgaagtcagtagcctggacattatttatgacacttatttttttttcccatcttgcccttatccattcattcaccaagccttgttgagt
				ttatcactgagtatctcattgccatcacaccaatctaggacaccatcatctcttacataggtgattacaatagcctccacactggcctccctgtctccgtttagctc
				atctcccaatatattttataaaaatgatactgttactttctctgctttaatggcttaccattacctttaaatggagtctgaatcagtggtctccaaaggggggtgatat
				ataagataatctgctagggtgcaggaggaaaatattggaacttttattcatatttacctttttatttgaaaaacactaaggcattaatatttaaaagctactactgtgt
				aatagttatttagtcattccttctttgctctatgtgtcagatggtcatttggtactaaaggtgtcctgagggaagcatgctttgttcactttctgcatgttgcacaatac
				tataatttgaatgtccatctatgcggatttatgagttatctagtttaactattacaaaatatgtaagtctgggattagggaatttgtggagaaaatcaagtgtttaact
				gcaaataagatcacattgttgttcagctggtaagatatacaaaatcaaatctgttctcatgaattaagaaaaattacgctgattttgaggttttaagtgaaacttttta
				aaaaattctcatttttttgtaaggcatccctttctgctttgatagccattaaaaatcaaatattcaaactgatgttagaactagatctttgaatctctgtatcacacggt
				gttaagatcttcagaaataatgaagcatattcaatatttta
1690	3533262	—	NO	tgggggagggaggatactactgagcaa
1691	3651809	—	NO	caaagatgagaggtgcgaagttgtccaagtccaacagctcaactgaactttcctaagtggaattgtta
1692	3719905	MLLT6	NO	ggttttgcatctcatttacttctccattggttcaggataaag
1693	3744442	—	NO	ctgagcgtgccatctcccagtggcc
1694	3994048	—	NO	gcaagcagcttgtcagacgtgcatgtggtttgga
1695	2566874	—	NO	ttccctccaaagtggaagtgagctggagagatctctgggtctgaaagtcacctgctatgttggaggagggtcaggctttttgaggactactctggtcaaggtc
				tgcagacttgatccctcctttaacccaaatcttattattatggctacacatgtgccacacattatagctccagatactcacgcaaggttc
1696	3788902	—	NO	agtttcttttggcaggtggtccagaa
1697	2684832	VGLL3	NO	aacacaaccatttacgatctcagtcagcagatttactctactcaaggaaaaaaagaaacaatcttattggaagcagatgttgacactgtgtcagttattgaagac
				ggaaggagttcacttgagccattgcagttacaaaggggtattgatggcagt
1698	2808743	—	NO	ggccaactgtcaagatgttttgaaggccaatctggaagtatatgttaaaataaagatgtgcataatttctaactgagcaactctactttgtggtatttatcctagag
				aaacattcacaattatgcccagagagatatatgtagggtatcccttgctacatggtttataacaaaaaaatatattagccaactagggtccattagg
1699	3311746	—	NO	tttcctcagtgcattcttggtggtgagattgattggtgagcatcgtataacccactctgggagcatagcctatttgtatttgtgtatgtctatactttgtgaggtttag
				cccacttc
1700	2398939	—	NO	atgaaatggtttggaaaggagcctt
1701	2948399	—	NO	agagggcgatcaggtctcattaggccccagggtgtctgaggggtgatctctgccagtggcggtgggcaaggcagaagaggcgtctgctgcagtggaag
				gatcatgacagcctgagttaaattccacctcttctcagctgtgaggtcttgagtaagtgattttgctactctgagtcttagttactttg
1702	2974531	—	NO	tctcattttgattctggcagtgggcccaaatgctaagtgtcttgcccaaagtagaaatttccagttgctacttccatggtgtgccgcacaggcaatggctgagtt
				ctt
1703	3385006	CREBZF	NO	tctggatgattagcacatggataaaggagatttctggaatataaaatggattgtttttgaaatttctaggtttggctctatttactgtaatggttgaaaacaatttagt
				atttgggtgacccttttgtttttcttctaaatgtgcctctggtaaaatacagaactagactaaagatgtagctttttaatatttgtcttttgatggtggcaggagttcata
				cattaattgaactaacacatcatattttgacctactatttctatcatattgacttactgtttctgcacttctttgaccagacttatc
1704	3777967	—	NO	gcgagtgactccgtttctttggacctgcggttgagctggcagcagaatggaggggtccgagaaacgggtgagtgtgaatcccttgcagaaatgctctctgg
				gggtctgcccttgaatgttaggcggcatgacaagtcaaatgcagtccaccagggtc
1705	2446212	TOR1AIP2	YES	atggccgacagtggacttagggaacctcaagagg
1706	2527475	—	NO	ccatttgagatgttctccgaggtgg
1707	3110892	—	NO	ttggtttcaaatggacagcagcaaa
1708	3229044	BRD3	NO	gatgtttctggtaatcatggacccttctcc
1709	3518549	MYCBP2	YES	caggaccaggttctcggttgtcatctcctaagccaaagactctcccagccaataggtctagcccatcgggtgctagttctccacgctcctcctcaccacatgat
				aaaaatctacctcaaaaaagtactgctcctgttaagacaaagcttgatcctcctcgggaacgttctaaatcagactcttacacacttgatccagataccctccgc
				aagaagaaaatgcccctcacagaacctttgagaggacggtcaacgtcaccaaaaccaaaatcagtaccaaaggattctacagattcccctggatctgaaaa
				tagagctccctctccccatgtggtacaggaaaacctccacagtgaggtggtcgaagtctgcacctcaagta
1710	3701324	—	NO	caaattacaattcaggttctgtttgaggtgctcctgagaagaggaaaagagtcagaaacctacacaaagatgtatagaagattaggtcctgagag
1711	2941831	—	NO	ttgcgtttacatgacttgagtggcctgtcagtcccgctagtaaagtctcctcatccatccactctgtttaaacaatcaaactctgaaacctgtgtctcctggaccat
				cctataatccctaaaataggctgttatgcttttcacctctgccctactctgttagcactaccaacttattgacctctttcaatcaaatcgttatctaaaggatacctgt
				aactcagataggttgcctactgggcctgtttagtttta
1712	3403963	—	NO	ttttttctgcactatggcttgggccc
1713	2337265	C1orf175	YES	gaaaggcaacaacaagcagtcacagggg
1714	2774211	—	NO	catcaggagtgtggattctgccattagtacccaacagatcaatgcccagtgtttc
1715	3626362	ALDH1A2	YES	gcttcagaaaggggacgtctgttggataagcttgcagacttggtggaacgggacagggc
1716	3760869	—	NO	gagcgtctctccttcaaatacctggatttttttttttttgtacactggttcatagatcggcacttgactttgaacctggcaccaaaaggcacaatatctgataccctgt
				acaagagctattagagatgctgccatatggatgggcaaaactgagccaatcccacttaggaatggaaggcttggacatggaagggaggatataaacgagg
				agttggagaaaaacgcaagcccagtttttgctagagtggaaatgaaagtgggaatgagggtcttgtttttagtcctctaaggaccaggaagcaattttaaaact
				tccttggtttttctgaaagcagcatattcaaaatgccagcaaaaactcctaacaactgcaaaaccaaaagaggatcaaagctcaccaacatcccttcttattgct
				gaaaggctctaaaattcaggatgccctgttcccttgtaaaagggaaaataattaagtctgatttatggtaatcataccacatcacacttctaaaaaaatattcaag
				tgtgtgaccaggggacgtttgacaccatt
1717	2772067	—	NO	cctcaaagtgtctaggaggcggtttgatatgcagactaaagtgaga
1718	3350159	—	NO	tttacatcatggtgtgtgacaaaacaattgcttccccctcctccctgcccttccccacccctgacttctaagataacta
1719	3946034	—	NO	aggtctgcccatcccaaacctgggt
1720	2699092	—	NO	gcttcaaacattggcccttcacgtacaacaaactctatcattcgatgtatcagggcgagcaaattcctacaacaacaacacagttaaagaaaatggattcaga
				cctaccactatataaaactacacttgacctaagttactataattgtgcagaaaatgattattctgctgactaacaccgaatttaataccaaaaaagtaacctggag
				catatgttaatgccttgtgcattaagagggtgtggggcagtgggagtagggaagtgggaggggatggaaaggtgagggagggtaggaaaccacaataca
				gcctcatagtaatatttaattttctaaatgtcacttattttccaaaagtaaaacattaaattataaatcacaactaattagaaagctgcaaatattgatatataaaatca
				gtaacttagagcctgcatgttattacagccatcta
1721	3027187	—	NO	gttcacggcagctcccaacaggtctgaggtaagacgccgctattatcctcgtttgctgggagaagactcgggcttagagcctctgattacacagctgcactct
				aaccatttcctaata
1722	3496668	—	NO	tctcatgtacctcgtagtatacctactatatacccagaaaaattaaaaattaaaaactaaagaaagaaataattgcaaaatgtaataatgtctttgaggggaaaat
				aaaaacttcagtgaaatactctaagaggggtttgatgcagagctgggggatgtgggaaagtagagataggaaagttgaggagggagggatgggttacagt
				ttgccaaggacagaattacttgagagggtgggagcaggacacacatgtcagggcctctggaacaggaagaggttggtttatggcagaaattgaaagaatg
				ctctcatacacagctcactttcctccttgctttttgtctgcatagcattattcaatatgtagcataatataagttgaaatcatatatcacctttgtggtcttctcccacca
				gaaatcaggcattatgaaggcagaagggcagaggtatttgtcgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtttgacttttgtatttttgctgc
				cgtattcctggtacctggaatagcacttggcagacaaatgtatgcaaagttattcaaatccagtgggaccagaccacagtg
1723	3718614	—	NO	cagtggggatgtagaatgtgtccaaa
1724	3759098	—	NO	ggggcagcacaggtactctgattttggggccacgagggccaaatccgcgcctgcacgtag
1725	2721510	—	NO	tattcctggactatagccgctgatctcattgatgcccttcttc
1726	2938424	—	NO	ctcaagagtgaacccggaaaggctcctaaggaggtccctgcctcagtccaggcaaggctgtggcctagacgaggtggcg
1727	3606484	AKAP13	NO	tgctgctgcccgcatgggatgcgcaggggaggcgtggggatccgcaggagggtggttgggatacaccggatacctctgctctcattgcttgtttgcaaatg
				ctctatggacatttgtgtgctaaatccta
1728	3750237	—	NO	ttcacccacatacaaaatagtgcgcgttttggctacttcagcctcttcccttctctagaaataactcctccttgtacttagtaaaggcacacattcacttcaagagt
				agg
1729	3320010	—	NO	caggaggcccgaccaaaagcagatcaaataggagtgacagagttcagagctgcctgggacaaagttttaaattttattttcactgcaacccataggaagata
				aacattttatatcatgacccagcacacaca
1730	3907649	—	NO	aggaatgggccgcatggactacctgggggtccccaaggccccagctcctctcctttccgcgccttctcccaacctttattgcagcgtctcctccggcgagac
				gaggccgggcttagaaaaagggcagcgaagacccaggggccaaactggcactgaggagctctggtctctgcgcggcggggcgccctctccgaatcag
				ccccaacaggcgtggcctccgggcttcaggcagcggggtaaggggccaggacacgggcacagggtctgtatgtaaacggtgacagcggc
1731	2546923	—	NO	ggctgtgtcacgtggacagtgtcacatctgcgggtggggataacaaggcacctgagtgcgtgaaggagga
1732	2788764	—	NO	ccatgggaacagtcttgcagtgatggacggtttccatcccccatcactgacgcgggaataactgtgctgt
1733	2886332	—	NO	cttttggcaaaaatgcgggccatggggtgtcaaag
1734	3307785	—	NO	aacttcaaactgtgctcatgtgggcacagaagcatcgtgcagggctgcactgtcaccagccccagcagccacagggcagtttgtcaccagctccctgaga
				atcaactccagtgtgatggaggtgaccc
1735	2339825	—	NO	tctttaagcgagaagtagatgtggggaggggttgttgcatttttaaagattcctgtattaggccgggtgc
1736	2922550	—	NO	gtgaactttgtacttacgtgtgcttttgtggtagcaagtatcatctttctgtttccttttagcatttttggtgtactggtcta
1737	3319874	IPO7	YES	tagcgcacagtttgacatgtcaacaag
1738	3571362	—	NO	tgggtactcgagcactgaagcattctcatcacttcccatgaagacactaatcccattaaactaggcattcctctttccctgaggttcgttgatagttgtatcttttgt
				catttcccatagtgggaaaactaaggtccgtggagggggatgtgaatccataatttctcttcaacaaacaggcagcagagccattgtggaatttctagcctaa
				gccataagatttgtggtttgtcctgatgtaagtgcattcactg
1739	2562256	—	NO	acaggcgggtatggtaatagcaatctcaggagggctcttctgttgctgtgtagaaaatgaaccaagtagcatagaatcgtgaccagctttccacacctggctg
				gagcactcctggggccttcagtagggacagttac
1740	2599272	—	NO	ggaagttactgcttcccctggtgtctgttcttctggcttcagcttcgctggggatggattc
1741	3019543	—	NO	gtggccttttaggaactgtagagtaacttaatataagagacattatttggtgggcagaattaagatcttgggagccattgctggtgcaatcctcacttgggaaaa
				tttaacaaaatatagttagaccttttccaggtctcacccattccatt
1742	3316144	TMEM80	NO	gagggccacattcggagcctccgtccactccagttttatcagcttttgccttttgcacggagtgctaaacaaattctagctctgtgtttttttcccattcccagattt
				actatcagttctccttaaaaagtatctaagctgttacagtagctttcccttcacttgattctattgtgtgttttctatgtttggaataattacacccaaatatctagatattt
				tctcttcaccgcattttgtaaata
1743	3808909	TCF4	YES	gtctatgctccatcagcaagcactgccgactacaatagggactcgccaggctatccttcctccaaaccagcaaccagcactttccctagctcc
1744	2360953	—	NO	acattctatcagagagtacatgatatcaccatgccttatcattggtgaagttaaccttgaacttggttaaggtgctgtctgccaggcctcttcactgtaaagttact
				gcttttccctcttcatactctgttcttt
1745	2458084	WDR26	NO	cagctgttctaggatcttgtcatttttactgaaagtctcgtgcacatgtgaagtgccctctgagtttaaggtttggttaatactggtatatttttataagattgaaattgt
				gtccccatctttaacttaaacattttcattatcagggtcaatgtgctagaactgaattgtaacatttttaggcacagatggaaaaaaatgttattggctccttgaaaa
				tgtgtgtgtgtggcgaggggaatagatccacaaaagcatgtatgtacttacaaaccaagctgtagagatcaagaaaagaacttaagtgttgatctcaagatttc
				taaattgtcaagatttacatggcattgtggtggaactagttaac
1746	2775432	—	NO	tggagaccagataatggatgctggcaagatctgggaatcaaagccatggaaagggtgccattggtcag
1747	3577885	DICER1	YES	tagataatatgttaatggggtcaggagcttttg
1748	2413468	TMEM48	YES	gctggaggatagttgcaagtattgtttggtcagtgctatttctacccatctgcaccacagtatttataattttcagcaggattgatttgtttcatcctatacagtggct
1749	2478883	—	NO	tgaacagacctcaatgtcagacaagccaggggagcctgc
1750	2783808	—	NO	atatttttaatggtgtcagccaggcaaa
1751	2406967	—	NO	ctcctgtgactcagagccctcggctt
1752	2436718	UBE2Q1	NO	tgctgtatttggatctcacgctgcctctgtggttccctccctcatttttcctggacgtgatagctctgcctattgcaggacaatgatggctattctaaacgctaagg
				aaaaaaaacaaacacagaactgtttcaagtactcaagactgacttacagaccaaccaaccaccttgctggaacccttgctagcaggcattcttataaaagaaa
				ctttcgagcctccttatattgctggaaactcagctgtgctccagactagagcctccttacctatgctatgga
1753	2663594	—	NO	ggcatcttatttcacgcaccacaggcccttgttcttcccagatgtcagcaggctttctccaataaatgcttcttcatttgctgttgcccttggaatcatcccagaga
				ttttaaacggctgtgtgtatgtttcatggggaagtctgtggcctccttacactgtcctgcagaactggcacctccggctgtttt
1754	2854791	—	NO	tttagaattgactgaggagcggccgggtgcggaggctcacatctgtaatcccacacgccttgggaggctctgaggcgggtagatcacctgaggtcaggag
				tttgagaccagcctggccaacatggcgaaaccccgtctccactaaaaatacaaaaattagccaggtgcagtggcacacacctgtaatcccagctactccga
				aggctgaggcaggaggatcacctgagcccaggaagttgagactgcagtgagctgagattgcaccactgcactccagcctcagtgacagcgagactgtct
				caaaaaaagaaaaaagtgactgaggaggaagaggccaggtggcaaatggaacagaatcaccaaagggtgaacaggactaaggcaatgtagtgtatgg
				ctcagctacgtcagagtggaaaaggtgttattagagcagaaactatggtccctgcgtcacagggaagcaacctacagagaagcagcagctccccaagag
				aggagagataagaagccagaagcctcagagtgaacaattgtccta
1755	3350791	SIDT2	NO	tcagagtttggtgtattagaggaactgccagttgttcatactggctaggcagggccttacatttgaggggagaagggtgagagattgagctgggtggagga
				ggacatgaaggcctttgggtgccat
1756	3447872	KRAS	NO	catcttcagtgccagtcttgggcaaaattgtgcaagaggtgaagtttatatttgaatatccattctcgttttaggactcttcttccatattagtgtcatcttgcctccct
				accttccacatgccccatgacttgatgcagttttaatacttgtaattcccctaaccataagatttactgctgctgtggatatctccatgaagttttcccactgagtca
				catcaga
1757	3709501	—	NO	gtccagtgcctcataacatggtctcaagctcttaacaaatggagcccaggattcaaaaatctgaactctaataatggcttgtcattctggtttcttacccttgagg
				aacctgtgaggtgttaaccaacctgtaagctgcattccagcactggcaaacctggcctctcaaatatccagccaattctaagtttggtgccagga
1758	3606344	—	NO	gaaaaaattgtcagttgcagggatacatttctcactaatgaagaaacatggaaaatatctgtgtaaggggatcacgctgtttcttaagttcagattattggaaga
				gggtggtgatgtaggtgtgtactcttcctgaggttg
1759	3884906	FAM83D	YES	ttctgtctggccaagtggttgaacactttgatctggagttccgaatcctgtatgcccagtccaagcccatcagccccaaactcctgtctcacttccagagcagc
				aacaagtttgatcacctcaccaaccgaaaaccacagtccaaggagctcaccctgggcaacctgctgcggatgcggctggctaggctgtcaagtactccc
1760	3919041	SLC5A3	NO	ttggaaacagaaacgaggcttattgctattgcagaaatcccaaactggcaaaggccagtatatatggtattccataatataaccagcttttgaaatttatgtgttt
				ggattagtgccttctggttaccagtattgactctgctagtttgcacctttccgttctta
1761	2847683	—	NO	ctgggaggctttcagatgcagcatccaccaaggaatacaccgactaacacacatgacagcctgaactagcaacctgcatcaacacccctgcagaaaagca
				gtgcatttcaactgctcatttaataagtatttgaattcataattacaaaacatcttctgtaattaaaccaccatatgcatttaaaatattttggggacaaagagtagca
				aagaattatattggatattgactaaaaacacttatgaatatcaataatttgctcctcctcccttttcatcatagactctttacaatgatactgaccttggggttg
1762	3776975	—	NO	tttgcaacccaacctgctggaagtgcaaagttcagaccagcagcaagaactcttgccccatgcttctgctgacat
1763	3543413	RBM25	YES	atctcgaaccagtggagcgcactcgtaacctggatcccagaaggtcgcgaaggcagtaccgtttcctcagcggc
1764	3653407	—	NO	ttgagtgtggtagtgtccgtctgtagtcccagcaactcaggaggttggggcaggaggatcacttgagcccaggagttcaaggctgcagtgagctataattgc
				accattgcactcaagctcaggcaacagagtgagaccttgtctcaaaaaaaaaaaaaaaaatttaaacaagcgacagtaatatttcattagaaatgtgatgaat
				gctatgaaggtgtagaggatgtctttagaatatataactgggagggagaccttttgagttaaggcaggtgctggtcaggaaagtcctgaggaagttacatttg
				gattga
1765	3670580	—	NO	gtgaaagactaaacagacgacttcaaaactctcatccaacatccaagagttctgccatttccaagattcagcaatcctc
1766	3767260	—	NO	taccagttagtacaaagatcacagccaatatagaacctaaaagtattcacaatgaaaatgacaatgtagttgtcgttttgagctgcatggtacttaaatctg
1767	2456432	—	NO	cacctgctccgagggtcagggctaagtggtttgagcaagtggcaagctcacaggtccagttggctgagggcctgacccatgacgatccattt
1768	2750681	—	NO	tatgacactgaatacgggaaagtgatgggagtgaggctggttaaaatttttcacccacgcagtctccctgtgtt
1769	3071991	LOC653852	NO	cacgtggtcactgacactcccatggc
1770	3436046	ATP6V0A2	YES	actcggatccgcaccaacaaattcaccgagggatttca
1771	2383133	—	NO	tcagccctgtgaagatgtcattccattatcttctgtcttctattgtttctgtggagatggtagctctcagacaaattgttggttgctcgtttgtacatactccccactcc
				catcctgccctgggtactctaacattttttcactttgtgtttagtttcagcagttttaagataacgtgcctaggtcgggc
1772	2434773	FAM63A	NO	actttccagccgcagagtagtgcag
1773	3338526	PPFIA1	YES	gtttggagcaatgatcgagtgattcgctggatcctgtcaattggccttaaagaatatgcaaacaatcttatagagagtggtgttcacggagcacttctggcctta
				gatgaaaccttcgacttcagtgcactggcactgctgttacagatcccgacgcagaa
1774	3671856	KLHL36	YES	caggcagacgcgagtgtctcggccatacaagatcagcgaatcatca
1775	3060641	—	NO	ctcccatggctggataaaccaaatctgatacatccacatttaaggttgttttccaagttggtttccataaaaggcctttaacaataataggcttttaacaacaaaaa
				ggtatccctcccatcacaatgagagcttgatgagggctcaaaagtgacttcaaaaactgtaaataattattttccttggacggctttaaaaacagctactgatag
				caaatcagaaacactaaagaaaaaagacaataaggaaacagctgtttgtctagtgaatccataataaataccaatttgaggctatagattacaaagccaaaat
				attcttataggaaagttaatgtttatatttacaatcccatggactaaaaaaactgtctaatatcttaaagactg agtctacctttatttaacattgtttatacacaaaga
				cccaagggatggtagaattcttgatccttctggacaaaagcatagtgagaggggactgaaattaacaaaaagggaaaattaacattaatctcaaaattctacc
				catcgttgtcttaaaatgatcaagactcagctacatctgagaaaaaggaaaaggatcagaagtgaaagaaatcagaagccagtaattaaaaaaatcataacc
				ttgtgtgctttctactgacggcatttaaa
1776	3379623	MTL5	NO	ctgtgcctaggctgttgacaacttttgctgagttggacagaataagactgtgggccatgctgcttgcttcactctctgggtgtgatggatcggtgagggtgcag
				ttgctatgattgtaattggtcatctcatcatggctgttaacatttctggaccaaacaaaaatgacttcagctacttccagattctgctgatacattacacaggatgat
				ctaaaaggctacagttctgaagatactcatctttcttgtaatctgggggcatctggtcaatagtattgcctctgtgctgtattgtgtctagaacattcaaggacattt
				gatacttctcatactttaattgcgtgctctcccagttgcagcaccctctgaggcttctatgtgttgcagccgatgggcatttgcacagagcagcagtcatgacag
				cgttttcagggcagctatttctccttttcccccttttcctctcccccggcttcccattctcctcctcctccttcctcttctcgtcccctcctcctcctctttgttctcctcc
				ccctgctcttcttcctctctccttttcctccttctgtgtctatactagattattttcaatcagtcacatgtttttctttattttgaatgttacaaaatatttctctattgtaaacg
				gtgtgccaggaaaaacatgagatgtgtatttgtattttttatgcacataattacttaatccaatgcctctccacttaattgggcctgatga
1777	3547548	—	NO	ccagtgttgggtgcaaatatacctaggata
1778	2779848	—	NO	atgagaagggtattggatacgattaggttagaagctcctagctcctcagtgaagtggtacataagggctctctctgc
1779	2869655	—	NO	ttctttttctaccctcactgtcctct
1780	2964686	—	NO	tctgagcacacctgtccagagagctc
1781	4004181	DMD	YES	ccttcagaaccggaggcaacagttgaatgaaatgttaaaggattcaacacaatggctggaagctaaggaagaagctgagcaggtcttaggacaggccag
				agccaagcttgagtcatggaaggagggtccctatacagtagatgcaatc
1782	2432028	PDE4DIP	YES	atgtctaatggatatcgcactctgtcccag
1783	2443375	F5	YES	tactcaagatcaagaagataacggcaattataacacagggctgcaagtctctgtcctctgaaatgtatgtaaagagctataccatccactacagtgagcaggg
				agtggaatggaaaccatacaggctgaaatcctc
1784	2736714	—	NO	ttccagagtttgcagggacagttagagtcaatatgaattctcagaataagcactgccagatagtccggaagccctttacaaggaaagtgacatttttgctgtgtt
				ttgaatagtgaacaagaatgtgcaggaagagaatgaaaggatatcactagcagaagaaatgcctctttgtaaaaccatagaaaataactctgagttgccatat
				aggacatatgagaatttcagtgttactgaaacaaaagcttttggaaaaggtatggtgattaaattgggtatacaatctgaaaggtaaattgaggacaacttgtgt
				gccagtttgca
1785	2969491	—	NO	ttgtagctgttagaagggatagttctacaaggtatccaaatttcctaagtatatttctttaaattttccttttattgaattttctgtttactggcattagtctcatatcagttt
				tggctacctttagctgcttttgttgaattctatttaataaaggcactgcaagtataaaattattaaaaatagacaagcacaatcctttctctgctaaacaagcttatga
				aaaacctggtgatacccaaagagctacaaaggaaactctcacacttg
1786	3417650	RBMS2	NO	ctgcacttgtggaacatcacatggcaaaaacaggagttttttcgctagactttttttttctttttaaccttattaaaaatgagattggtcctaa
1787	2586174	—	NO	ctttgcttataatgttctgtagtgctgatggactgcctgattgtaga
1788	3777613	—	NO	aatgctgcaggcatcagtgggagag
1789	3888166	CSE1L	YES	tgacatcccgtcttcctatatggccttatttcctcatctccttcagccagtgctttgggaaagaacaggaaatattcctgctctagtgaggcttcttcaagcattctt
				agaacgcggttcaaacacaatagcaagtg
1790	2332174	CTPS	YES	tgaattctcaagaaacgtgctgggatggcaag
1791	2684865	VGLL3	NO	agaaccaactacagtcacctctgctacctcagcatgggctggagcctttcatggaacagtagacatagtgcccagcgtgggattcgatacag
1792	2756426	—	NO	aggcaatggcgattttaggctctccaggtgattacaatatgcaaccatgctcccaaatgtctgctgtaaaccaacatctttcggaggaccagttgaaaataatat
				ttctcaaattaatgtgaaaagtgtttgctgttgagttgcggcctttcagtcccgcctttgttctctactcaccactgttgagttgtggcctttcagtcccgcctgtgtt
				ctctactcacctctactgcttgttttgctcctgattcaaaccagttccacacatactaagcccactgtgctaggtggcctgaccgtggtgaatattattgtggagg
				aaggactttgctgtaagaaattgcattccccaaaactgaaaccatgatatttactcaactgaggtaaaaaatgaaagactaagggggactcccaagggtcag
				ggcaagaataaataccttggaatattaatacccatctcatgatgcctgagtgtaaatgctcc
1793	3309131	C10orf46	NO	ggaaatgctaatttgagcttcattcataggggaacctactatatattgcatccctgctggttggaaattatcttcatctctggactgcattgtttagaaaaatgttaat
				ggcttacaattctgagaactttattgtgtggctctg
1794	3435688	ARL6IP4	YES	ctgacggatgagcagaagtcccgaatccaggccat
1795	3544550	LOC731223	YES	tggaaagctttgaagacggcggttctggg
1796	3737293	KIAA1618	YES	tgaaggcattgtctgcatttccaagaagcacctagataaatacattccttacaagtacgtcatttataatggggaatcttttgagtatgagttcatttacaagcacc
				agcagaagaagggcgagtacgtcaacc
1797	2769855	—	NO	ttagtttgggtctgatctttgtttc
1798	2914869	—	NO	cttccttgtggaagttggcttgatg
1799	2754682	—	NO	acagagcccgagcttttgtcctgcaggctcaagcttctagattcgtcttctcgttaatgcggggacggac
1800	2353146	—	NO	ttccagcaggcaccgaaaaagccctgtgagcttctctctgagcggtggagaactgcacatgtatggatgttgctgcttcc
1801	2685210	—	NO	atatttgagtgtcttattggacttggaacttccaccagtatctccagaattattgtctgtctgcag
1802	2774664	—	NO	agttttggttccgacaagctgcaccattccaactgcc
1803	2517907	—	NO	tacacaaattgaacgcggtagggtgggggaggaagtagggagataaagcctatgctgctgattcctcaattataggagcagtctctaaaagccctcgtcaat
				ctagtgatgtgt
1804	3156168	—	NO	gtgcaagctgtgtagtggatcattgagtgt
1805	3359979	NUP98	YES	ggactctttggaaccacaaataccacctctaatccttttggcagcacatctggctccctctttgggccaagtagttttacagctgctcctactgggactactatta
1806	3701355	—	NO	tcaataaaagttgtattgagatgtgattcacatactgtacaatttatccctttaaaatatgcaattcggtagtttttagtgcattcacagagttgtgcagccattatcgt
				aatcagtt
1807	2329396	HMGB4	YES	gtcagctagaaaccggtgcagagggaaaag
1808	3290788	CCDC6	NO	tccatgctcaagagccattgtaagagattaaggggtttctaggtttttggtgattttttgtttgtttttttctttgttttttttgggtttttttttcttctttaattttttgattaaaa
				catacacacagctgttagcataaagtcgtggggggcattttctggaatgctcagcagttctgattaactgccaagcccaggttgcctctcatgaggcaactga
				aaaaatcctgtgtcttgatagcatgggtgc
1809	3449856	—	NO	ctttgactccattgtctgctttggct
1810	3573894	DIO2	YES	aggggaaccagagcgcacaagggaa
1811	3670649	—	NO	ccacgttgtcaagcacagaactataaaaacaatggattcagtgggtgaaggtaggagaaggggttcaagagattcagacttacagtaggaaagttatttttcc
				aatctcagtaagttttttagggttatgaagattgagcactgacgacgctgaaataccacagtgcaaatgcttccgtagattccctgggctctgcactcaccagat
				ccatttctatgataaagcacagagctcctcaaacagaacagtcgagttgcaggctcagcagcctccttgtcagtgtcctgctcaactcagc
1812	3851066	—	NO	tgcagtgcctggatcataactctggatcatcactgaaacct
1813	3912092	SYCP2	YES	tccttgggagacctggcaaaatgaat
1814	2626159	RPP14	NO	tctacttttaatcaggcgtggcagc
1815	3448099	BHLHE41	NO	caccagctgtaaaagatcctatgcgaaagacactggctcttttttttaatcccccaaataaattttgcccccttttaggccatgttccattatctcttaaaattggaa
				cctaattcgagaggaagtaagaagggtctgttctgtggctgagctaggtgaaccccggggtaggggaaagatgttaacacctttgacgtctttggagttgac
				atggaacagcaggtagttgttatgtagagctagttctcaaagctgccctgcctgttttaggaggcgttccacaaacagattgaggctcttttagaattgaatttac
				tcttcagtattttctaatgttcagctttctaaaaggcatatatttttcaaagaagtgaggatgcagtttctcacgttgcaacctattctgaagtggtttaaatggtatct
				cttagtaacttgcactcgttaaagaaacacggagctgggccatcgtcagaactaagtcagggaaggagatggatgagaaggccagaatcattcctagtaca
				tttgctaacactttattgagaaattgaccatgaattaatggactcatcttaatttcttctaagtccatatatagatagatatctatctgtacagatttctatttatccatag
				ataggtatctatacatacacatctcaagtgcatctattcccactctcattaatccatcatgttcctaaatttttgtaatcttactgtaaaaaaaagtgcactgaacttca
				aaacaaaacaaaaaacaacaacaacaaaaaacaagtccaaactgatatatcctatattctgttaaaattcaaaagtgaacgaaagcatttaactggccagtttt
				gattgcaaatgctgtaaagatatagaatgaagtcctgtgaggccttcctatctccaagtctatgtattttctggagaccaaaccagataccagataatcacaaag
				aaagcttttttaataaggcttaaaccaagaccttgtctagatatttttagtttgttgccaaggtag
1816	3872452	ZNF552	YES	agcacgagagactgctccctacagaagaaccttctgtgtggtgtgaatgtgggaaatcctctagcaaatatgacagc ttcagtaatcatcaaggagttcacac
				tagagaaaaaccttatacgtgtgggatatgtgggaaattatttaacagtaagtcccacctccttgtacaccagagaattcacactggagagaagccatatgagt
				gtgaggtttgtcagaaattttttaggcacaagtaccacctcattgcacaccagagagttcacactggagaaaggccatatgaatgcagtgattgtgggaagtc
				atttacccacagctctacattccgtgttcataagagagttcacactggtcagaagccttatgagtgcagtgaatgtgggaaatcttttgccgaaagctccagtct
				cactaaacacaggagagttcacactggagaaaagccttacgggtgcagtgaatgtgaaaaaaaatttaggcaaatctcttcacttcgtcatc
1817	2489627	POLE4	NO	gtgttctgcataagtggcttcctga
1818	2934111	—	NO	tcaagattatatatggcagatgaggataa
1819	3181290	TMOD1	NO	gtaatggcccagcttagagacttcagctactgatctcatcacttattagacaaattgctgctgaccttacgcctgtatattaagcctccgcaggatgccggacaa
				tggtgaagaaactccagatatcaaggaattgggaaatcctggccaaaccaccccaagatgattacactgaaatgtagtattagtactgctgccagatctcttttt
				aacatcatgtgcgtctcttgggatccagcaaaagtgttaagccacaatgcccttgtgccttttaatataccacagtgccagttaaactaatatttttgtttgttgcttt
				tgggagttattttcattagtgatttcagcaaatctcatgataaaggacaaggtcaagaactccagagcactgagcagagaggctggtgatgaaaaggtgaag
				gcctgcgcactgaactgtaa
1820	3487237	AKAP11	YES	aatgttccctgtgccaagttcacaagtg
1821	4009127	JARID1C	YES	tgagtgtccccccacagtagtggtgaaggaggagttaggtggggatgtgaaggtggagtcaacatcgcctaagaccttcctggagagcaaggaggagct
				gagtcacagcccagaaccctgcaccaagatgaccatgaggctacgga
1822	2750647	—	NO	tgagtacagcccactgattgacattcaagacccattggaaaaatcaggagacacaagagtgggaagagtgcagattggagcagctatccaaaaataca
1823	2916198	ZNF292	YES	gggctggacttgctacctgtatagaactgtgtgtaaaggctcttcgcttggagtctacagaaaatactgaagtgaaaatatctatttgcaagaccatttcatgttt
				gttgcctgatgatctggaagttaaacgtgcttgtcaactgagtgaatttcttattgagcctacagtagatgcgtattatgctgtggaaatgttgtataatcagccag
				accagaaatatgatgaagagaatcttccaataccaaattctttacgctgtgagctgttacttgtattgaaaactcaatggccctttgatccagaaactgggattg
				gaaaaccttgaaacgacaatgtcttgcattaatgggagaagaagcatccattgtgtcttcaatagatgaactaaatgacagtgaagtatatgaaaaagtggta
				gactaccaagaagagagtaaagaaacttctatgaatgggctttctggtggagttggtgctaattctggccttcttaaagacattggtgatgaaaagcagaaga
				agagagagataaaacagttaagagagaggggatttatatctgctcggtttaggaattggcaagcctacatgcagtattgtgtgttgtgtgacaaagaattcctt
				ggtcacagaatagtacgacatgctcagaaacattacaaagatggaatttatagttgccccatatgtgcaaagaactttaattctaaagaaacttttgtccctcatg
				tcacactgcatgttaaacaatctagtaaagagagactagcagctatgaaaccattaagaagattgggaaggcctccaaagatcacaactaccaatgaaaatc
				agaagactaatactgtggctaaacaggagcagcgacctataaaaaagaatagtctctattcaacagattttatagtgtttaatgacaatgatggttcagatgatg
				agaatgatgacaaagataaatcctatgagccagaagtgattccagtccagaaaccagtacctgttaatgaatttaattgccc
1824	2984592	SFT2D1	YES	tggcttccgggcggcataaagctttttgcagtgttttataccctcggcaatcttgctgcgttagccag
1825	3123564	—	NO	cagttcattccgtttccacctggcagctgctccctctgacacccaaggactcgcagggagtggccgttggacctgcagacc
1826	3165879	TEK	NO	gtagcagccagtcccgtttcatttagtcatgtgaccactctgtcttgtgtttccacagcctgcaagtcagtccaggatgctaacatctaaaaatagacttaaatct
				cattgcttacaagcctaagaatctttagagaagtatacataagtttaggataaaataatgggattttcttttcttttctctggtaatattgacttgtatattttaagaaat
				aacagaaagcctgggtgacatttgggagacatgtgacatttatatattgaattaatatccctacatgtattgcacattgtaaaaagttttagttttgatgagttgtga
				gtttaccttgtatactgtaggcacactttgcactgatatatcatg
1827	3887555	—	NO	tccattccaggattggtgctgaagcacatgtgtcctgaagttcaggacgtcagggtaattgacacagaagaaa
1828	2356740	—	NO	tataatctagaaacattcttcagcgttttttttctttcattacatgaagagtcaagaccagtggttttgtggaatgcatgataatctgggttcttaaaaatcatttcttctt
				gattagatttcccattgtcttgaattgactcagtcagcctttcctcaccgctactccaggttcactaatg
1829	2665536	C3orf48	YES	gagaatggataggcttttaggtcttggaagaaaagaagtgtccagggttcaatggagtggctgctct
1830	2833553	—	NO	ttttggggatgacattgtggaaagtttaccctca
1831	3242698	—	NO	tgtaatacctcatcatagatatttggggtgcccttca
1832	3911222	PMEPA1	NO	gaagttctagccactcgagctcatgcatgtgaaacgtgtgctttacgaaggtggcagctgacagacgtgggctctgcatgccgccagcctagtagaaagttc
				tcgttcattggcaacagcagaacctgcctctccgtgaagtcgtcagcctaaaatttgtttctctcttgaagaggattctttgaaaaggtcctgcagagaaatcag
				tacaggttatcccgaaaggta
1833	2676501	—	NO	attgaagaaccgctgctggagaact
1834	2839345	—	NO	gcagccttattcagcaacgctggggatgacaacatg
1835	3239038	—	NO	gaataagcagaaacggctgggcgtg
1836	3475695	ZCCHC8	YES	cctcggaatgctgctcgaataagtgaaaagagaaaagagtatatggatgcctgtggagaagcaaacaatcagaatttccagcagcgataccacgcagaag
				aagta
1837	3563672	—	NO	gttctgaggcccagcaactctgaga
1838	2333149	CDC20	YES	acctgaaccttgtggattggagttctgggaatgtactggccgtggcactggacaacagtgtgtacctgtggagtgcaagctctggtgacatcctgcagctttt
				gcaaatggagcagcctggggaatatatatcctctgtggcctg
1839	3740914	—	NO	ctggtgaggagccgcaactgggcatctcc
1840	3949524	—	NO	ataaaacatctttgacgtgggagctgcagtactg
1841	2598329	FN1	YES	cattgtctccaccaacaaacttgcatctggag
1842	2354732	—	NO	gggtgtcatggaatcttaggagccctgcattccaattgcccaggctt
1843	2534399	—	NO	cagaatgatggagtttgcatggcacagt
1844	2677654	C3orf63	NO	cagtacctgcgcaatccttgatttaatgaaattaaattttttatttcaaaagataggcttctgtttatcaaaggcgttgaacaatttgatttttaaattagattttgcaaa
				atggaagtataatgggaatatatttttgaggtggtcttagtagtaattaccatttgttgaacacattaatgctatactagacagatacagtggagatagctttcaaa
				cccgtatctattcctaactactgcctctaatactaattactaacttgttactaatgctaacttttaaaaatgtttttgaaaattgcaatttctacaaataaatgtcatagtg
				caaataaatgtcaggatttagagaaggagcctaaactgaatttgtgttatttcagtaaaagttatggagttatgggtctagacgtgttaataagttagacagaact
				ttggcactttagaacaaatgcatgagtggtatttcagttcctaagttacataaaaagtgtgaaagaacactgtgaggtcccagcaacgccagactatattaagg
				taagtagaaagtgtttttatagggcttcaatacccaggtggtgacagagcagaagaaccggtttttttttttttttttttactactaagcttttacaaaagaagtatctg
				ttttattgtatagaacaagtacagcattttactacatagtatacaagtttttaatgagcatttaaaaaaataagtaaatctaggctatttgaaaaatacagttgagcca
				gtgagcacattttataatttggaagacacaaatcaaatgtgaaggatttgattttctacatttaaaatgaagaaccaaaactctcttcttgattttcagctaaaggca
				ggagactactttccaactccttttgcttctggagaaggccctgaaatcacattgatatatgtttgttagtaaaatgtgcacacctgacttgcaatgttgtgttaaact
				agaattatattcacttggaaaacatatcgcttaggataaaattttgtca
1845	2495347	—	NO	agaaagtcttaatgggagagtgcccatggtatat
1846	3436411	—	NO	caccatccttgaggggtcgagccaggactggaacctcagtccggccactacaacttcataaataccatcgccctgagatgctgaaatcccaggggccccc
				caccctcagaccaggtgccggtattg
1847	3630941	—	NO	tccctggtatgtacacgcattcctgtgttttgtgaaaaaccgacaccatgctcctccctcactacatgtaaaacacttttattcattaaaaagaaaactgactggct
				tggacctacaaattagtttcattatttgttaatgtttgaaagccattaaaagatgaatattaaggtttctttatactcaatacttgtagttttgtttgggggaatgagag
				gatgcccttggtacctttgtgaggcctctccactgagggtcaatcatgacttctgttttaaaccagcccatcccatcttctccagctgctctccttatgtcttgcttct
				ctcccctccaaccttctcagcataaggactcaatcctaggctcctaccccagacgggtgccttccaacgttcctggtgc
1848	3886257	—	NO	cacttgggttggaaactctggcttctttccccccatggcctgtttggctcacaggtgccaccagcctcaccttgatccactgtcacttgtgcttactcggtgttag
				ctgctttgcctcctttcagtccctcgaaccctgagctcttctcagagctcctagtgctcctctgtcggcctgcagtgcactcccgcttgtgcctattgtgta
1849	4004292	—	NO	aggatgaattctcaccaaccatatattattttccgataacagtgtttggtagtgagggggatctattgctaggtaaaatacgatggattcaaggagcttactgtttg
				atgatagggcaagatgtgttcatggatactagattgaga
1850	2960481	—	NO	ttggagccagtcaggcttttgtttagacattttaactttttcttgctttccttgcaaactcctcagccttcagactggttggaaagtaaatgtacaatcttacataaattt
				tcaggtaatagcatttcagctttttccccaagattttttgcttgggaggagacagattagactggattcggagtcttgattttgcaaaggtaacaaaagacatgttt
				ttttataagacttttcatcataagtttattttattcaacagaagcaaaatctaatataatggaaaaaataaagatctgtgataaatctgatctgtgtggataaacacaa
				ttagaaagacttaaagattaagtattgaaacaaactaccaaaatattttaatactgatttgtaaaaatttcagtacatttttctcttgcttaattctactgggtcctgttt
1851	2977359	—	NO	tagtcattggtgaagcaggattccaa
1852	3199214	—	NO	tcaggcttctgttgcaagccaatgtagggaacca
1853	2743060	—	NO	ttcctgagttcaagatatagttaagtttaaataataggacttgtgtatgaattggatggtgtgggagggaaatcaaaagttctgggccgggcgcagtggctcac
				gcctgtaatcccagcactttgggagtctgaggcgggcagatcacaaggtcaggagattgagaccatcctggctaacacgctgaaaccccatctctactaaa
				gatacaacaaaatccgggcgtgg
1854	2811122	—	NO	aggagttctccacatactctgcccaccctgatagcaactgaggtaggccagaaacactcatgcactggttacctcctgagccatccacagaaagggtca
1855	3560070	—	NO	gtgtgatcaaaaaagtggtcagtgtgaa
1856	2597541	—	NO	acattgaaattcaagatgcaggcagagaaagaggacatagaccagat
1857	3747622	—	NO	gcgcgtgctcaacttggatgggacacacctagtctttcttcaagtccctggattcaaagagcttcaaccgttcttgcaccgtcaggc
1858	2332216	—	NO	ttgattcatcctatccgtgagcgtgg
1859	3029849	—	NO	gctggcaccccagaagaagctagctcagcatgtgcgggtc
1860	3090304	ADAMDEC1	YES	atacattgatctctatttggtgctgga
1861	3441298	—	NO	actatctgaaaatgggcaggtggtgca
1862	3584491	—	NO	tgcgatctccgctcaaaaagatacttttgaatccttttcaaaagtaatttgtgtttcattttttaattagtatgataagcacttcaagaccctttacaattctggctagat
				ttggttgccatatttaatagcattttataaataatggagaaaagggaaacattatgcatgcttgattacggtcatgagctgcattaacaattccgttcaacaacaga
				ctgcatatgtcagagcagtcccttaagattacaaa
1863	2775809	SEC31A	YES	gtaaactttgaggatgattctcgtggaaaataccttgaacttctaggataca
1864	3380586	SHANK2	YES	tttcgatacaagaagcgggtgtataaacaagccagtctcgatgagaaacagttggccaagctccacacgaag
1865	3410510	—	NO	tgtgtcccgcagctcaatcagacttctggatgccatcaaggaggtctgcatgacctaaggatcattgttctttgaaaggaaaacaagttcattaatcttactggc
				tgccagggttaggatgcaaagttaatcaattattagtgactaccgtctaccgaatgactacgtgcaagcagtcatgcatggaggaagaaaaggacaaagag
				aaaggaaaataagtaaaaaacaaacgtttaatgattttgataatataggctcagttacatcaccacaaaca
1866	3266758	—	NO	gttctggaactcttcacacctgtgacctgcat
1867	3878506	SEC23B	YES	gaaactggagcacccatcctaactgatgatgt
1868	3189392	—	NO	tgcaagattcttggatcctcgtccggtacattttggctgcattttatgtgacgtttgtgagggggttagaaatactttaaaatttcagggaacttgaataacaatga
				aagatgtgcagctagtccaaacagatggacttcagtagcaattccaggggcgtttc
1869	3737624	KIAA1330	YES	ctccctgcagaagcgtcccgacggccacatcgtgagtgtgag
1870	2587558	SP3	NO	tagccgctctcgaaaacctacgctgccacggccgctcattgtctctccccttccacccgggggcaaacaggaagcgcgccgcctggcagaccgacggac
				aggcgcctggaccaatgagcacagccgacaaagagcacggcggcgaatga
1871	2636399	BOC	YES	gccctacgtggtgtcgggctacagcggtcgcgtgtacgagaggcccgtggcaggtccttatatcaccttcacggatgcggtcaatgagaccaccatcatgc
				tcaagtgg
1872	3383004	RSF1	YES	aactgccagtcatagtgaagctagaaaaacctttgccagaaaatgaagaaaaaaagattatcaaagaagaaagtgattccttcaaggaaaatgtcaaaccca
				ttaaagttgaggtgaaggaatgtagagcagatcctaaagataccaaaagtagcatggagaagccagtggcacaggagcctgaaaggatcgaatttggtgg
				caatattaaatcttctcacgaaattactgagaaatctactgaagaaactgagaaacttaaaaatgaccagcaggccaagataccactaaaaaaacgagaaatt
				aaactgagtgatgattttgacagtccagtcaagggacctttgtgtaaatcagttactccaacaaaagagttttgaaagatgaaataaaacaagaggaagaga
				cttgtaaaaggatctctacaatcactgctttgggtcatgaagggaaa
1873	3959450	—	NO	tgtttttatcacagggccgtcgttgaagcatgtatgactatgtgtgtgaaaatgttctgcaaaccaaaaagggctcaggtgctataatt
1874	3984482	SRPX2	YES	gatgagatgccacgcactaccattcatcactagtggcacttacacctgcacaaatggagtgcttcttgactctcgctgtgacta
1875	2333884	—	NO	ttgtagagtatgaacactcctttactttcagcaacgtcggcatctccaaataa
1876	3392870	—	NO	atgcatgagggcacgcctcctactttc
1877	2395894	CLSTN1	NO	gccgcgcggtttcccttcgcagatgtgtat
1878	2701311	—	NO	attgagcctgcccatcatgcattgcaacaggaaggtggatttgaaaagggaaaagaattaaaacatcccatcacacgtgtaat
1879	2976681	—	NO	cagatacgggtgtgtacttgaatcaaggagaggcagtagagcagccttatgttttgttccccaaagagtgagatgtgtacccaattcttgcacatagtgaaga
				agctgttctcttttttgttgtttgtcacatctgattattcatggagaaagttgcagcttggggctagtaaaatttttttttaacaccgttctcatattatttgctctcttctttt
				aataaaggacagataggccttgatgtggctgtaa
1880	3398768	—	NO	gcaactttcagtggaggcgctgagagcaaattgcagcagagatgcgctcagggtgcagtaacaaggaaggacccgctctccgtgtcagtggcctgcagg
				ggaagtgagaaccgggctcatgctgggctcctctactttgcagggtttaaggccg
1881	2376766	SRGAP2	YES	actacagcatgaaggaattttccgggtgtcaggatccca
1882	2648351	—	NO	ggagcagcttcaatcaaaaggcggggctt
1883	2855376	FLJ32255	NO	ccttttctgggggatcctaggcagaagcgatggcaggacaa
1884	3715585	—	NO	aatcaccatgacaggcagagtgtgggca
1885	2432021	—	NO	agtttagttctcttacgtgtggctagccaat
1886	2527209	RPL37A	NO	tttttataatgtgtctaggctgggt
1887	3753258	—	NO	ttgagctgcccaagccacctagagg
1888	2607727	—	NO	gctgtgcgaatggactcagctgcccgaactcacagaatatcagtaacagcaccgaaacttcaca
1889	2970557	HDAC2	YES	gctgtcaattttccaatgagagatggtatagatgatgagtcatatgggcagatatttaagcct
1890	3233715	LOC399715	NO	ccttctgcaaatggggatgagtcctc
1891	2555212	PUS10	YES	catgctgcatggttgctggtaaaaca
1892	2601671	DOCK10	YES	tatcctggtggagcagctatacatgtgtgtggagtttctctggaagtctgagcgatatgaactcattgctgatgtcaacaagcccatcattgctgtctttgag
1893	3630677	CALML4	NO	tgggcctgaaaacttggagcaattaattttttttaaaaagtgttcttttcacttgggagagatggcaaacacagtggcaagacaacattacccaactatagaaga
				gaggctaactagcaacaataatagatgatttcagccatggtatgagtagatcttta
1894	2677724	ARHGEF3	NO	ggcgccatcagccacttttagaagccatcagccagtgtgttgggaaaagaggtttgtcaagtgttggcctatgggaaggtggtcaatgaatgttttga
1895	2898386	—	NO	tggaggcatttaatggcgatgtgcaggtgcaag
1896	3412766	ARID2	NO	catccacctcgaaagctgggcattaacgatattgaaggacagcgggtacttcagattgcagtgattttgagaaatctttcctttgaggagggcaatgttaagct
				cttggcagctaatcgtacctgtc
1897	3975856	—	NO	tggaatgtacctggaatagggaagtggacagtgagggc
1898	2466297	—	NO	ccaggtcgcacatcagctgcaggcacagccagttcatgggtagacagccacatcctgccccaggaggagggcagccagcatgggcgatgcaagctcc
				cctcgtctggaaccagcacaacctcaggcactcgagccttggcccctcacaagcaacgtcctcaatgggtggcgttcgttcat
1899	3240817	—	NO	tccatcgattgactgcgaggggctagggttcacagcaagcagaacgtcctgggtttctcttcaataccacctcctcctctcctgttcagatgctgagaaacatc
				tggcgcagtagagatgctgcctctgacatttctatgacaaaacgcgtgcctgtgctagggtttgcacaggcacaagttatcacaacctcgggatggggctg
1900	3454311	LASS5	YES	catcacttggtcaccattgggcttatctccttctcctacatcaacaatatggttcgagtgggaactctgatcatgtgtctaca
1901	2437092	DPM3	NO	gggagtgggtctcaaatatagagggggtagcaaggtggaaggggcccttccaccttttgtgggcactcaagttcggacctctgggatcggcgattccc
1902	2683293	—	NO	catctgtgcttgacgcagaggcctccggggtcgcgagcttcggaggtggaggtgccccgtcttcgggttcccacgccgccctggcgacctggggctcca
				gccccaccgcggactccggtgggacgtgggtggcgcaagcacaccttgcccctgtgactcagcttgagggggcccaagctgtcccactgagcacgcgc
				ccagcaggccgtcgcgctgcgggtcctggtcctcctgtcatttactggggtgcggaggcctccgaggagtctgagggtgggacagtcccacttccggag
				gagctagggcagggaacacaaagtcccgagtgccggggca
1903	3701415	—	NO	ccataaaattcgcatggtgaaatgcacgtaacataaaatttaccatcttaaccatttaaatgcacagttcagtggtatcagatacattaata
1904	2590322	—	NO	ctagaattaagatatgctgatgagttgcttctgcagttcat
1905	2973489	—	NO	tttggcgtttgctacagaatggtgaatttatgtatttctcttccactttgacatggacattgcctcattcttcagtagtgtgcatattcaccttaatttattcaaaagctat
				tttacctttttcaataacaccacatcaattaccttaacttattcacttacatcagtcttccc
1906	3020769	—	NO	ggatgcaggactgagtcatgccact
1907	2807755	—	NO	gagtagatgtaactaagaggtttgagaaaggaatttcagcagagttattgaaggagaagtcaaggagaggagaaggagaggagcagtgaatgttgtcgtg
				aagaggtgttgtcttgaaatactg
1908	2918704	PRDM13	YES	ctctggagtggatagggttaatccgggcagccagaaactcccag
1909	3024096	—	NO	taacaatatgtgcaggcaggaccgaaaa
1910	3270274	—	NO	gggcgctttcccactgttctagacgtaggagagaaagcacttctcagatggtgagcttttatcttccaatcttgtcaaccgaggagacctggaagttccctttca
				acctggaatgtgagccctgcttgctgggcacgagataaggaccaaggattgacccaggacaatttcagagagcacaggggtggcatatcctcatgtcagg
				gcgtggagctaatattcaga
1911	3356025	—	NO	atggcccagaatgggttgtcagtgctccag
1912	3913713	YTHDF1	NO	ggaccgttgagctcactaccacctggagtttgagttgaagcatgaaaatggtgcccatgcctgacgctccagcgcctggatctgcacgtgcccttgtagagg
				atccttaccgtcctagagagcagacgctactgaaaactacttgctccaaaagaccctctgagttaacgatcagctgtatcattagacttgtatttagagcgtgtc
				acttcctctgaactgtta
1913	3506761	—	NO	tgtagtgttgctgtatcttccatcgtacagtggaatggcatcttacagaaggggtttcggtcctatggttagcttaatgttgaagtcagggaaagtcaaaatcacc
				attggaactcccttcaactgtctataaaatacactatgcacagtaccttggtttacgtatatttgcataaatacatactttgtatagtcacatgttgtatgacaacttac
				tgagttgttcgatgaacaactctatgtgctaataataattttgatgtattaaaatgggaaagcatttgcttaactgagtggagaggcacaggttgctgagtcagac
				gtatctcctgttgcacacgtaccttcaggatgg
1914	3888725	PTPN1	YES	gcagatcgacaagtccgggagctggg
1915	3357756	—	NO	tctgtccagagtgcaaggccgaaccagaggacacacatgatcatttctattttagaaacacgcctggggcagagaggacagcaggtgaaagagactgag
				agagaacagtcagaggctagtactggccaagacaggagagtgagggagcaaccgtaatgaggatggatgaataatttgagagagatttaggggtaacga
				accagactcactc
1916	2371244	—	NO	atgagctcaccttgcctgcaactgtctct
1917	2660674	—	NO	tgcccatttttctacggcttgttgatttcttgggagttccttgtaagctttatagtctctgtaattaatgagttccaaacatttttcctagtttgtcttttgtcttttgtttttgg
				tgtggtgtgtcaaacagaactgtttttttgttgttgttcttacatagtttaatttttaatgcttctgtattctaaatcatagccaaaaatgacgttcccatgcaaaggaat
				gtctcatgttttctttggatacttgctgtggtttcattacttttccgtggaaagctctgatccttgtgcagttgatcctgatataa
1918	3199144	—	NO	tagaatgtttgtatattgctgcctggc
1919	2411720	—	NO	agatccaattagagccagggtcagg
1920	2682075	—	NO	tgataatagggacgttgtcagacccttaactaagccacacactgctgggagcctccggaataactttaatgtagttgtagggaagggagtcgaggcaggga
				tgaggatccctgcttgactgctctctttcctgacgaggaagaaaaggacagtgatcaagcacagggtctcaaaggaggtctta
1921	2709855	—	NO	ggacagcattacggtggacagtgaa
1922	3016026	MUC3B	NO	ctgcaaaacgggtacagcattcctgtatgatagctcacgccgtcgttgtgaaaaccacatagacttggtcaattctcggtcctactctgccctcccgtctcagc
		///		cctcgtgttgccattgc
		MUC3A
1923	3550736	LOC730217	NO	accactacttcatgcagggcagtgtgcc
1924	3059100	—	NO	ggaagctaccaaggagactattaaagaaattcaggatggtgaagacagcttaaagggaaacagttctgcaaatagaggcgatgggagatataggaaaga
				gggactatgtgtaggtcttgttgcgtcgctgaag
1925	3379723	MRPL21	YES	tggttggggcagacaacttcacgctgcttggcaagccact
1926	3432355	—	NO	cgtcgtggatggatcagttttgctcgatagagggacatgtttttctgtggcaacaggagggcaaaaggagaaggtggccacagatgccggtagatgagctg
				agagtgattgtattccctatcctctcggaagcttgaggcaaggccatcaacagacaatcagagggaataagaagagatagaatatatgaagaaagggaga
				aaagatgaaatcgtaattgtgtagcagggcaagaagtccagaaatttctgtgctgtgccaagttcccagttgaggcggtga
1927	3511352	—	NO	ctgacggtttaagatgctgcattttaagtaatgctgagttgtatttttatttcagtcattcatttctacttattttgagcacccattatatgttaggttccatgctaggcac
				tgtaaagataaagatgagaaagactcagcccttacctaaaggagtatagagcctagttggggagacaggaggcagatagttacagcatggagagcaaatt
				ctctgagggaggaatgaagtgagataagagcacagaagaaagacccggggatcagagcagacttcctggaggaggcaatcattgacttg
1928	2627501	—	NO	tcctgcttgtgaacagattcctatttccgtgaggaggtgacctcgaagaagagcagcttctattctgctgggaggtgtactgccttctggtatcaggcttctgca
				tcccgggaaagctcgggataacctgaggcacc
1929	3608077	—	NO	agaccacaatgagggacatggcaagttcct
1930	2393810	—	NO	ttgaggaaaattgctctgtccctat
1931	2506539	—	NO	tccatttaaatgagagggtggagctgtccttgcaaaccaatgatgcagctgatgccatgcagtggatcttccttccccctaaa
1932	3068053	—	NO	tttcccagagctctaccttgttgtcagcactccctgcaatag
1933	3762439	—	NO	ctaagagagttactgaccctaactcccctaaaacctaactatcaaaagcctaccactgactggaagccttacaataacactaacagttgg
1934	3896232	—	NO	tcagtctgcgatgaaggtgaacccatcttataaagcagagcttacttacattctgcaggattttggtgtggatgcatagaaggcttacctggttagtaagcctcc
				attcctccgacctacagaaggcaacccttctgcagctccaagcagggatttctagaaaagaccaggtgtacaaaacatctaagctgtgcctcccaccacag
				gtggggaagtcccctgatttggtcagacacagatgaatgtctgtgtctgactgagcccagaaacagttcaattgatgggggctggaaccaccaagaaaaca
				ctcctgacctgggcaacactgtcttccagattat
1935	3916144	C21orf74	NO	tgtgtgtacctgagataagatgatgtcttgtccaatgctggtttccaccttgtgccctgagctgttgggagaggctcctgcgacctgtgac
1936	2389578	—	NO	ggcttacgcagcagatgcacgttcagcattgagaacccggtccgacaggaaagacacaccatttttccgccagaaactccagtgttcaaaatacaaactgc
				caacttttcaggcaataatcatgagcttccattagaaaaagccatcagctcaccagacgacgaaatatgctctcgggattaagaactttctcatcctccctgag
				ccctttcctttcaggggaagtgcaagtttg
1937	3290995	ANK3	YES	agcgggctaacaccactgcatgtagctgcacattacgataatcagaaagtggcccttctgcttttggaccaaggagcctcacctcacgcagccgcaaa
1938	3403153	EMG1	NO	tgtcacatcctttgaccctggtctgagctgactgctggaagatgatctttctgcactgagactgtggagtttggggaagccaaggctgtacatttgctatttgttta
				tcctatgaatactgttcttgcaaacctggttgttttggggttcctaaagtatccagtggtgtaaaactgtttgttccccgggacttcagggacagataggaggtta
				cagagtttgcagtttggttccatgctttgaaggcaggctttagctcccagattcccatgtgctaaaggagagaaccctgatgatggagaagaactgtgaaaga
				gagcagtcaggaatgctagtggtgaaaaactgaacaaacagaagtgattttatctaatacagttccaaggtagaaaaagtggagcaggcagggccttgcac
				ccctctccacccccccatggggggggtggtggtagcggcacatacacaatc
1939	3439875	—	NO	acctggctttggttattgatgagaagagtaattaatagaacattccctttgctgtgataccctacccaaaatagctcggttgttggttcactttcttcagatacctcc
				ttgtctcatggaccgcctacttact
1940	3568358	—	NO	tcatgggtttccaaatatgggatgcaatttcaagttcttaacaccaaatataaccctacttgttttagtttcctggcattcatcctatcatccccagtttactgcacctc
				aggttatcaaggatgtgggagggattctacaagggtatgttcccccagagctttttggtaccctgcaatcccagaagttgttgatgctaggatgtctggagagc
				actggccatttattactga
1941	3701322	CDYL2	YES	tgacgtgaatcacgctacactggcggagaacgggctc
1942	2975832	—	NO	gccatgatcgtagcactatactctagcc
1943	3072788	—	NO	gtctaattcagaacccggtgggctctccatgcattattggcagcacttttatccaggggcacagacagggaatagggttactggaaacagggagtgtagctc
				aaggaattgttctctctctggagtggataagttgtttgacctactgactcatttcataggaattaggaaaacaacctagtgtggtttttattgttagtcctggaggat
				tccaaaatctgtgtgcctgcaaataagatgagctggggaaagggagcaccagcatttggtgtttctacttgcctcttttcctgatggaatccaatcctctgcttc
1944	3380982	—	NO	gctgtttcagtccacaccttgttcacagtaagatattcaattcaattcagcaaacatttgttgagtgcttgctgctctgtgcctgaccagaagaaatgaagccaag
				atacaaataatagaaccctgtcatgagcacagaaagacctgctgagtttctattgattgtggtaaaccagcctgcatccagttccaagtaacagctgcccactt
				agtgaatactctctcatgtttcaacactcagttctagtgtagcctcttctataaagcctttcttttccagataaaattggttaatgtgtcctgtgttaggctgattgatttt
				gatgatccctattcatggtctcccctgtatccatctctttttgcctataacattgtagtcccatctcactctgatgctgggaccagacatgtgacttgttttagccaat
				gagatgtcgataaacatgaagcaaacagaagctttaaaggaggcctgccctcttgctctttgccagtgccatgagaacatggctgatcagctggagggttat
				gagatgtgtaggtgagagacatgcaaaagagccagagataccagctgaagccatcctagactagcccacagtcagcctacccccagtcaagatcaggag
				agtcacccaacccacagatgactgccgacacatgagtaagcc
1945	3902033	—	NO	attccacgcgtcaaattgtgggcagtga
1946	3952107	—	NO	acaggcacaggggagtcaagcttag
1947	2678585	—	NO	agcacccagtctctgttctcagagg
1948	3463862	PPFIA2	YES	tctcaggggatcacgagtggaatagaactcaacagattggagtactaagcagccacccttttgaaagtgacactgaaatgtctgatattgatgatgatgacag
				agaaacaatttttagctcaatggatcttctctccaagtggtcattccgatgcccagacgcta
1949	3727958	—	NO	caccatcttctcggatggatggcaaag
1950	3974043	—	NO	agcaagccagtgcagtccttggtcacagtcactcacag
1951	3982214	—	NO	ccaaaaccaatgtgtctaaggtgcggcatcttg
1952	2685843	—	NO	gcggtggtccaatcatagttcactat
1953	2686522	ABI3BP	NO	ccagacatgccaccaactaaatccg
1954	4014220	POF1B	NO	cttcctctgtagctgccagacctgc
1955	2838069	TTC1	YES	aatggccatcaatgactgcagcaaag
1956	3701416	—	NO	cgcatctggcctataccagtgtatgttttctttaggaaaaaataaggcagaaaccagaaaactaacacttcacataaatgtaggtgcagaatattggtacgatat
				tggataacttaaattgctgaactgtatgaaacttaatttttctaaggcaaaaattgatatcattggaaggatcttggagtcagtggcaggcaaacaaaatttaaac
				ttggctgcattttcttttttcgtttcaaatgaatacttaactaggtgcaatggctttatttgtggtcttc
1957	3756107	—	NO	tgaattcacagtgttgtatcccatgtagggaaaaataagactaattttccccccacactctaacacactgtaattttgcacttggaactttgctaatctactgtccaa
				cctccttctcaacaaagtcaaatcaaaggagaattaacctagaagaggggacaataaaataagaggtcctcagggagagggagaaccaaggaaatagaa
				tctacttaaatctggccagatagcacctcgtggatt
1958	2382147	CAPN2	YES	atgacaggctgcccaccaaggacggggagctgctctttgtgcattcagccgaagggagcgagttct
1959	2590022	ZNF385B	NO	agagaaacacatcactagattgacgagggcttttagagactgctcctataattgaggaatcagcagcataggctttatctccctacttc
1960	3831701	—	NO	gtattggcgactgcctgtgcatacac
1961	2792492	—	NO	ctgactgtgaattagagtttgcgctattggaaggtggaacccactgtgctcattgtata
1962	3289301	—	NO	gcatttactagtgctgtgtgcctcgttgcttttctgggtagtgtttggtgatgggcatagtgtggagtggtggtagagtacacagtgtgattctgtctggtaagga
				agctgtatgttgatgttcactgatgtgaataggttcatacagtcccttaggcatttggctggaggataaagaacagccattgaccagcagagtactttttttgaag
				tttatgcaagacagcgtgctaggtactactgccagcttga
1963	3686344	XPO6	YES	gtcctttctccagcccgacatccacctttttaaacaaaatctcttctacttggagactctcaacaccaagcaga
1964	2596800	—	NO	tgactaaaattttgggtctgggctgttatatcactttgtgttaagttatttgtagtagctaatgtgctaacttatatatgtgttctttctgattttttggattttaccttttgatttt
				ggcataacttatctatatttttgtttacattattttaaaaatatcagtaactgtaataatataaaattgaagttgtattgagttgacaatacctctagtttttaaggtcatctgt
				cacataatttaagtgcaccagttcctaatgtataaag
1965	2614940	—	NO	ctgctccattggagacttcctgagggcaacagacaaactatttgatagctgaat
1966	3988991	NDUFA1	YES	tcattttgggtatcactggagtctgatggaaagagataggcgcatctctggagttgatcgttactatgtgtcaaag
1967	3068834	—	NO	tcatataatagacagtgcggttgcaccttgtgttcatgtactgatagctgttaagggtgcagtgatgaaccaacagagctc
1968	3116499	—	NO	gcctctctgttctcatgggctacatg
1969	3227229	FNBP1	YES	ccaacctgaacgaaatgaatgattacgcagggcagcatgaagttatctccgagaacatggcatcacagatcattgtggacttggcacgctatgttcaggaa
1970	3777767	—	NO	tgtgtttggggtgattagagcttcttgcaagcttagaagtaggaagctaatg
1971	3950135	—	NO	cactggcacaggacgaccctgaagg
1972	3425446	—	NO	gcatgtcttgctactacttcatagatgtcataagacccgtttatggattagagttggtgtagaaagccattgccttgagttgaaaaatgaatactgtaaaagctca
				atacaaatcctccaaagcacatgcactt
1973	2359042	—	NO	ccaagttctcatcttcagcatcgcagtttcgttctccacc
1974	2437704	GON4L	NO	ttccattctattactcttaggtttgtatctcatggaattcactttaacctctgcctcgtgttatttgctttagctgtacattatgctctta
1975	2778373	—	NO	cccaaaacatagatccgaacaccagctttgccc
1976	2954503	—	NO	atttcctacactgttgatggtggcaatgacaaaatcaattgcagtg
1977	2441001	—	NO	ctggagaaatggctatgggtgactg
1978	3162378	—	NO	gaattagttcctcagcccagtgtaagactggattaaaaatcgtgcatggatgtgcaggg
1979	3199012	MPDZ	YES	cacccagtcagtcagagtcagagccagagaaggctccattgtgcag
1980	3449682	—	NO	aagggtgtggcacattgctggtgttttcagggaagaaagcagaacgtctgtgggcaagcagtgg
1981	3687337	—	NO	ggagatccttgtgtagcggcagaaagtttagcaacactgtctcctgcattagtgtggagggtaggaaatatacctaaggaacggatggtctagctaaggagc
				tttccagacagaatgttgaaggtgccacctggcttcttgctgcttatagtaaaactgaagaggagagagtaagttaaagaaaaaaaacacttaaatgaaaaag
				agcctgaaattgttgggtttgaaaattcccagcctttccagataacaagtgatgttaaaattaacaaatggcttccgtgcaaagattaaatacaaggcattaaata
				cagggaaatgtggtctaaaggtcaagctgaggatgtgatgaaaaagtcctttgttaagacctcagaaataccaacaagatgcctcagaggggacttccagtc
				gaatgaaataataatcacgcttctgagaaggttaaaggtgttgtctttcagcgtctcagcacaagcccaaagtagagaagggcttaccttgcagagattttc
1982	2333554	ST3GAL3	YES	cctacccttggcagtgtggcagtga
1983	2570354	—	NO	gtgttacttccaccatggtgccacacacttaatatccattcc
1984	2873144	—	NO	ggggcttctctatgcccggaaactgcctcatcaactgaaacaaatcctgaatcatcaaagggccaaacccactgccacctttagacggagcaggagagtta
				ccctggctctgtcactgccactaagtcta
1985	3409485	—	NO	tgaataggcagctagtacatgaacctggcattaggggtttggggctggcatacttaaacatgtggctagatgtgatcaccttcagagtaaatgtaaatagtatc
				atccctccttatctgtatc
1986	3476542	—	NO	gtgtgttccaggcgatggcaggaggga
1987	3620299	—	NO	atgacagtttttctctaggctaataactcaatgagcagaaaggaaagtcctcccttttaaatgtatatgaatgtatatgtagttcacacttacactctgacacagat
				ctcattgtgtccaatgatgtgtgtgtgtgtgtgtgtgtgtgtgtctccaagactgagacacatgtactaaagagtgatactggccacatctactctgggcttggag
				ggtaacttcagcaa
1988	3626913	—	NO	tgcaacctcgacctgcttggcttaagcaa
1989	2699759	—	NO	ccatcatgagctgaccaacaatttctaaattcctactcagaaacacagcaaggggaatgcagtcaagcacaaagggcttaaatgaccagataaggctgggc
				tggatgaataaagaggaatatcctatgaatgtgactgtgtagttttagagtatcccgattcaactgttatatttgacttgtggccttgtagacagtgtgtta
1990	2737582	—	NO	tagccaagtgcagagggtgtctccgggtgtgtgcgtggcccacaagagggcaagaagagagaaggcggggataggagggaagagggtgggggtga
				gaggcagccctgagagggcggaggaaggaagaggctgggagctcggcgcccgcggcgcagctgccgtcgctgccgcagctgtccagggaggatcg
				ccaaaacggcgacgaataaacaacttaccttgcggagaagagctacgactgcgatgc
1991	2964449	MDN1	YES	cccgatggaatatgcaggctctggacatgattagaaatttgatggactttgacccacaaacggaccagcctga
1992	3695220	DYNC1LI2	YES	ggagctgccttgatttacacatcag
1993	2939888	LYRM4	YES	taaagaatatctcctccaggtgtggt
1994	3632627	—	NO	atggagatctacactgacaccctcagtcctagaggcagagaagaggttcagatctggcctg
1995	3695228	DYNC1LI2	YES	cacgcgctgcaacgtgtggattctggatggagacttgtaccacaaaggcctgctgaaatttgcagtttctgctgaatccttgccagagaccctcgtcatttttgt
				tgcag
1996	3854016	—	NO	tagatctcgtcgctggtatgcttggttccgctcctcgtttcttagttgcttattctacccgttattcactgatgtta
1997	3980369	FAM155B	NO	tccatcacagacagcagagccgggcagctttcttatgccattttctacactgtgcttcatgagtaggactttcttgcactagttcctatgactgagtctccaaact
				ggtttcctagtagtcccccatcccttcctcccttacccagctatgattcagttgtctctgccctccctcttaccctgcctctgtgtttcggtgagagtc
1998	3799919	—	NO	tgtattacacagagactaccgcacaaaacacggacccaatgccaggcaagcacgcgcccagcctgaacctccaagaactgtctt
1999	3032425	—	NO	cacacctgtaagctgaggtgaaggagtt
2000	2475245	PPP1CB	YES	aaagaaagctaaataccagtatggtggactgaattctggacgtcctgtcactccacctcgaacagctaatccgccgaagaaaa
2001	3487169	DGKH	YES	tctggggataccgaaagtgggtcatgtgaagcgaattctccag
2002	3955155	—	NO	aatgacatcccttttgagctgtggatggtg
2003	2827160	PHAX	YES	cacggcaactgcatgtgcaccagtatcacattatcgagctgttgaaagtgtggattcaagtgaagaaagtttttctgattcagatgatgatagctgtctttggaa
				acgcaaacgacagaaatgttttaaccctcctcccaaaccagagccttttcagtttggccagagcagtcagaaaccacctgttgctggaggaaagaagattaa
				caacatatggggtgctgtgctgcaggaacagaatcaagatgcagtggccactgaacttggtatcttgggaatggagggcactattgacagaagcagacaat
				ccgagacctacaatta
2004	3186892	—	NO	atagataacgtttgtgtggcactccccaagactcaggcattgtgataactaacactttccatgaataatgtcatagaattctcacaaacatcctgtgagatagac
				actattattttcaaccccatgtacatatgagaatactgagagttggagagactgagtaacatgccctagatgactcagctagcaaggaatgaaaagcacattct
				aactccacccacatatatagttccaggatcccatctctctacctcacattaattagttctataccagctttatgtttcctactagaatgtgcatgttttaaaggctgag
				ctttc
2005	3195536	—	NO	tggccttctggacagtaggtaggcatgtgatcactgttgtcactaaacctgggaaatgattcctgggtcagggttcattaattgc
2006	3238305	—	NO	gtattgaaattcctcgagccgctgcttttctcactccataattctggccagaatttggtacttaaaatattttgtctaaaatattacaatagctacttaagtcatctccc
				tgactccactctgttgtctttcagggcgtcgtccacactgtagccaaagtgatcttataaaaacataattctaatcatggcactcttctgcttaaaaatgttttaatg
				gctttccgttaggttaaaatttaaaagtcctttgtagcctgtgaga
2007	3744218	VAMP2	NO	acttgctggaaaacggggatgcttgcccctctccaggactattgagcccagagagagctgtcctctcattgggtgaactgattgaggaagggtctattgtcttt
				ttaaatggcacaattttaagggtttgagggtacagtcccttaacctgccacgggagggggcccccaaactttcttccccccacacttctggttttctgtgtggag
				ggggagcagggatatctaagctgtggtgtgaaagggtaggagagatgctggaggtgggggtgctgtgttttagaccccccatattatcccagtgtcccctg
				cccccctcttcccccaccccatgcccccaattctgtggcgcatccagattgtgaaaatgta
2008	3810033	—	NO	gtgaatatatctaggtccagcagggtctcagaagcagatgccaacctgaggggaatatttaccagatga
2009	3943786	—	NO	cagcagctgctatccatcgtcatcaccagtgtcatcatcgccatccccatcatcaccaccaacaccgccacccccccagcgacacactagctgtggacaca
				tcctttacgcccttgaacctgagtttctacagctatgaagcaagtcccatggaatttacagaccaaacgctaagtgtagggctccctgggagctggtcttatgg
				agcacactggca
2010	2321472	—	NO	cagtccatgaggtccacttgtctaaatatgtcacttgaagtgcaaggtaccaattgctcagtggctcaaaatgattttctggttctgttgtcatttcaagagcttctc
				ttgagggttgagagagtctgttttcctaagaatctggttctctccatcagtctctgtttccaccttatcttcctgggaaggtgtgctttctttgaggtgagatgtgaa
				gcctgcccacgtgcagttttatgtcgaattccaagtcagatcttaacttggtactcccggagcctgttggaagtctta
2011	2361272	—	NO	gtgcaacatcactttgacttgattattcttgggtctgttttatttcccgcttttattttgcttttgaaatctttttccttggtggatttgtacgtgtcttcactagatgcctca
				aattaagtctgaccacaatcctactctactt
2012	2447714	—	NO	tgccaacttctcttcaccacacaatctgcagaagc
2013	3175671	VPS13A	YES	tatgatgatgcctatagatttgggggaaaagacaatatatttagtttcattctttgaaggtttacaacgcattattttattcactgaagatccaagggtatttaaagta
				acatatgaaagtgagaaagcagagttagcagagcaagaaattgcagtggcattacaagatgttggaatttctcttgtcaacaattacacgaagcaagaagta
				gcctatata
2014	3517776	—	NO	tataaggacttcacagatagctgccgtggatgctg
2015	3626941	—	NO	taatttcacaatgggtgtgggaggttggtgagtagatggactagattcaaaagtagatacctcgctctcacctatagcctagcagttt
2016	2467805	TTC15	NO	ctccaacacactacgtcagaaggacccgg
2017	3701421	—	NO	ttgctttgtcttgtgatcgcagctcacggcagccttggactcgtgggcacgag
2018	3717066	NF1	YES	cagaaagtgctgcaattgcctgtgtca
2019	2476534	—	NO	agatggtacaaaggtcgtgatagggctg
2020	2750682	—	NO	ccaagattaggccactgccctgtaac
2021	2412205	—	NO	gggttaagctgggaaccatgtctcctggggcaaaattttaattcttctagccacttgttatgtgatctcaagcaaggtacatacgtctctgggtctttttttctttatct
				aaaatatgaagagattaagtgttttcttaattttctttcagctctgatattatgtgattctgtgattaaatgacctggatgttgataatacatgcc
2022	3019902	—	NO	ctttggagttttcgcccagatcagaattttattgccttttgccgtagactgctgcaagatttccagagcaaagagaaggtatagtgttccttaatgtgagttatgaa
				gatcaaaatacagcaaagagaagatttcagagatttaaaagtgataatttttactgaaatttggaaatatgtctccatattttaactttattttataaaaaagaattact
				ctgttttttgaaatggccaagcattaagtaatatatgaccgtgaatttcttgagggtgggaaatgtgactggattttatatttcgattgtatcacatgcagcctc
2023	3750928	KIAA0100	YES	acactatgtggcattgtgctttggagaagtgcgtatcagaacggacctacagaaagtttctgacctgtctgccccattc
2024	2511032	—	NO	atgactgagtcttatagcggtgttgggcatagca
2025	2568632	—	NO	atcctttgtcccgattgggtcccagatacacaaaa
2026	3039827	—	NO	gagtccttcctggatagcagcaccaaag
2027	2437284	C1orf2	YES	cagctgccaccggttggagggctgg
2028	3076362	—	NO	gcatacaagtctgcccagtcccaggaagaaagaggagagaccctgaattctgaccttttgatggtcaggcatgatggaaagaaactgctgctacagcttgg
				gagatttgctatggaaagtctgccagtcaactttgcccttctaaccaccagatcaatttgtggctgatcatctgatggggcagtttcaatcaccaagcatcgttct
				ctttcctgttctggaattttgttttggagctctttcccctagtgaccaccagttagtttctgagggatggaacaaaaatgcagcttgccctttctatgtggtgcgtgtt
				caggccttgacagattttatcaaaaggaaactattttatttaaatggaggctgagtggtgagtagatgtgtcttggtatggaggaaaagggcatgctgcatcttc
				ttcctgacctccggggtctctggccttttgtttccttgctcactgaggggtctgtctaaccaagcaggcta
2029	3527927	FLJ10357	NO	tgagtcagcatccccaatttctaccacatccagcactcctaccatcttgcatgtaccttccttcctgtccccggctacttgggagtcagcttcttccctctcccaac
				tcatctccctcttct
2030	3889598	—	NO	caggtcttagcggtcatcaggatgaaggcggtgggaagtggagcaacagagatccaaatatggaaagagcacgtgctgataccagaggcactggaaata
				atagcaatatccgaaagtctgctcaccctgcgtcattccttcagacagtagtcgggctctattc
2031	3735624	MFSD11	NO	ttaaaatctgcaatactggccaatattcttttatcaaacaggagaccgcagctttaaagggggaaaatgcagacgttggataaaaacagcaagaaatagtcat
				tttcattaataggtctcaaacagtttacgaaacagccattattatc
2032	2739508	—	NO	ggcatgtgtgggtaattagttctcactatggttagactcctgaagtgagtggtccaagttgttagcgtgcttctgctctgtgaggccaggccagtatcctgtctg
2033	3819517	RAB11B	YES	gacatcgccaagcacctgacctatgagaacgtggagcgctggctgaaggagctgcgggaccacgcagacagcaacatc
2034	3330082	PTPRJ	NO	ggggtcagctatgcagcccatcacgtgtgtttttcatctgggatgaaaaagcctggttctcttttgaaatgcttgattgtacttattgagctaaacaagtcttggtg
				actgttgttgatttgcctcaaaagttttaagtcctgggttttcagactactgtgta
2035	3378442	SPTBN2	NO	ggccacattctcctaatagcatgaaacagtcagctcactttctgcctcctcctcttacacttccctgctgtccactgcggccaactcagcacagtgtccttgaag
				ctgattgagggtc
2036	2473789	—	NO	gcgcgggctttcgagcacatacaaacctgattacaaaagtcagatttctttatttcgtcttgggcacgtcattttaaccccgctcagcctctcttttgtgtatgaaa
				ctgaaagtaatagcttctgctgtgcaaaatgattagaggaatttgtgaagcgcttggcaacatactaggaccc
2037	3115627	—	NO	ttgagatttatgtgtgtgccagacacacacacacacacatatgtacacaagcaatttttgtgtgtgtggctcaagccaggcagagaaagacaaatactaaatg
				atctcactcatatgtgaaatctaaaaaagttgatctcaaagaagtagaaaggagcctggtggttatcagagtctggggagggggttggggagatattggcca
				aaggatatacaatttcagttaggtaggaggaataagttcaagaagtcgattttgactatagttaataatgtgttgtattcatgaacaaggctaagagagtggatgt
				aaagtgttcttaccacaaaaaggataactacatgaggtaatgcacatgttaattagctagatttagtaattccataatgtatccactg
2038	2745189	—	NO	tccatttctttttactgcgtccgtccctgacaatacctgctgtttactcagcccttaacgttg
2039	3450260	—	NO	aaagtgatacatttgtgagggaggagg
2040	2656876	—	NO	cagaccttatctcatagggtgattatgagcattagatgaaatcgtgggtgaaaggctcagtacagtgccaggtatacaagaagcattcagttaagtaatagct
				gttattgttataactgaggttttcacaagccgcacact
2041	2952697	—	NO	gctagtttcaaagactgcgaccctgttttgaattggcttgtttatgttgcgacggtggctggaagccaggccaacccagggtcagctttcccaaatcagtcgcc
				aaggcccacgagaacagtagtttcagaactcccagaaataggttcaaagatgcctgtcctgtaccagtcctgcccagcctcgtttttccttaccaccctgactg
				cagtcttaactcctgcaaactaatttgatcgctctaagtttaaccgcgcccagaatttcacttttgcttgcttggcctttgctgtgggtcacaacagcccttcttgc
2042	3579549	WARS	YES	cctggcctctgtaagcctgtgtatgttatcaatactgtttcttcctgtgagttccattatttctatctcttatgggcaaagcattgtgggtaattggtgctggctaacat
				tgcatggtcggatagagaagtccagctgtgagtctctccccaaagcagccccacagtggagcctttggctggaagtccatgggccaccctgttcttgtccat
				ggaggactccgagggttccaagtatactcttaagacccactctgtttaaaaatatatattctatgtatgcgtatatggaattgaaatgtcattattgtaacctagaa
				agtgctttgaaatattgatgtggggaggtttattgagcacaagatgtatttcagcccatgccccctcccaaaaagaaattgataagtaaaagcttcgttatacatt
				tgactaagaaatcacccagctttaaagctgcttttaacaatgaagattgaacagagttcagcaattttgattaaattaagacttgggggtgaaactttccagtttac
				tgaactccagaccatgcatgtagtccactccagaaatcatgctcgcttcccttggcacaccagtgttctcctgccaaatgaccctagaccctctgtcctgcaga
				gtcagggtggcttttcccctgactgtgtccgatgccaaggagtcctggcctccgcagatgcttcattttgacccttggctgcagtggaagtcagcacagagca
				gtgccctggctgtgtccctggacgggtggacttagctagggagaaagtcgaggcagcagccctcgaggccctcacagatgtctaggcaggcctca
2043	3703035	—	NO	cgatggacactgatgcccacacaggtg
2044	2444562	RC3H1	NO	tccagatggatcgttggcctaaattttcacacttctccctgttcatcctttttcctcttccctgcttcctgggaataaaaggaacttttttaaaaaaattaattagtcc
				acaggtctcattatctttctttatgattaatctatgactttttggtacaagaacaatggaaaaagtgaattaaggtaatgaacaaaacctttcacccacttaaacattt
				tccagttttgagattcctcttcgtgtttgtggtgtcttccccttgttaccccttctgccctttttctctgactatggtaatttggtctttaggctcatatcagtctccccga
				gacattctgcagtcattatcacctttttgggtggattttattttgttttattttgttttttttaaaaaaataactttttaacattggtgcatatttgcttgggatagagcttgtg
				taatttaccaatcgtattgattgtaagtgattgtgccctgcagaggtatatttaacaagacaaaaataatcttggttaataaaggagcccatgagatttgagtcag
				gttgtaagtgaaatcacttacacttttggatagaatttatactcctgctcttataaatcagtggtagacttaccattttttaaagttttcttgcatttttttgtttttttattgc
				cacagctccctattctttcttgcctgcctccacccccctgttcaggaaaaaaaaaaattgagccttaaagtgacagctgattttttaattgctgaattttgtgaaattt
				tactttttccaagtgtttccaactttaaaaagagaagtgaagacaaataggttggaatggtgaagacaaatggattggaatttcacaggctgtgaataattcctta
				ggatctggcaaaccgtgaagtcttatttgaagaccttatctcctgagagttcttttggagtaggaaaaagaaccctatttgaaatagaccgtttttctcttgtttttaa
				tctgtttaatatttctgatttttaagcagcttt
2045	3816284	DOT1L	YES	ccaggtcgtgctccaggttgctgctgccaccaactgcaaacatcactatggcgtcgagaaagcagacatcccggccaagtatgcgga
2046	3231694	—	NO	atccaccaagcagtgcgtccaggtg
2047	3760111	—	NO	gaatgaacgcagagagtgtcagtgctgaca
2048	3960937	—	NO	caggcacaccgccttgaggtgggcagtgccc
2049	2519659	COL3A1	NO	gaaagattcattggcatgccacaggggattctcctcc
2050	3380965	—	NO	tctaacccttgagacactgccaacatccctcctagtacaagacttttcttggtgcttgctgtttttagaggagttttggcccttcagtgtttgtaaagctctcggatc
				ctcagaaaaaaattctttagtgattaattttgaaattggagctgtttgattattttgattaagaagctgattttcggcctggcacg
2051	3690096	DNAJA2	YES	agatgggaatgatttgcacatgacatataaaataggacttgttgaagctctatgtggatttcagttcacatttaagcaccttgatggacgtcagattgtggtgaaa
				taccc
2052	3777917	—	YES	aggatcctgccgaaaggtgctcagtggcct
2053	3811929	—	NO	atgtatcattctccatacacctgtgcctt
2054	2436400	—	NO	ccagccacgcgtccagcaggtcagggatt
2055	3868616	SHANK1	YES	tacatcattaaggagaagacagtcttgctgcagaagaaggacagtgaggggtttgg
2056	2833315	—	NO	atcttttgattgctagcccagctgctttccttgttatcactttgtggagcaggctggacattgacaatgagttctgagactgagtggaatgggagacccctccca
				gctggtggtcgagctgcctagagcatggtccatctgtttgggactagggttgagctcc
2057	2886091	—	NO	tgacgaatttcgtctttcttccctacggtggagtcagtgttaaacatacaacaaggagttctggggcacaggc
2058	3146585	RNF19A	YES	atgtccacgatgtgctgcttatataataaagatgaatgatgggagctgcaatcacatgacatgtgc
2059	3271059	—	NO	gtgagatacttgacatggggacctttac
2060	3589673	—	NO	ttcaagaagttctggggacagaggg
2061	3971336	MBTPS2	YES	tccttggaaaaacgctgatgcagactttggcacaaatgatggctgactctccctcttcttattcttcctcctcttcttcctcttcctcctcttcttcctcttcctcttcttc
				atcttcttcctcttcctcgcttcacaatgaacaggtgttacaagttgtg
2062	3304025	—	NO	gtatgtgataagtatttggatttgagagtagacctttcatagtgaggcttatcaggttgaggggaggtgatgactggaaatatatttatttattttaaatcccactttg
				gctttagtaaaatctgaatatgtgtgcatttctagtttcttacaccaaatgtaggttccgtaagttcatgcaagtacagtgggtc
2063	3350758	PAFAH1B2	YES	agacaaagagcctgatgtactgttcgtgggagactccatggtgcagttaatgcagcaat
2064	3921733	—	NO	cagtgtcgctacaggggatctctcaggctcacaacgggccactcctctagggaagttctggtctcatcatgatccttgtttggtctcactccccatgtccttctct
				gtccctcctccaactgccatttatttatttaactgaaaaagtaccaatcacccacataggcatga
2065	2361637	—	NO	acaggagccaatgcccaatcatagc
2066	2625412	—	NO	accacctgggtattgaagccctataaaaacactttctacttaccttaatatagtctggcgttgctgggacctcacagtgttctttcacactttttatgtaacttagga
				actgaaataccactcatgcatttgttctaaag
2067	2737704	—	NO	gattgctatggaagtactgagtccctgaaggagagacaaggtgcaggaagccccaatcgccaggccatcgatgaaattgtggagggcatcgcagagcgt
				tatcatccaggcaatcgtccctatt
2068	2795252	—	NO	gttcggatgatttcacgggagcagc
2069	3203541	AQP7	YES	gctgtgacctttgctaactgtgcgctgggccgcg
2070	3510917	—	NO	aagaccagggtaatcatagaactgccaagcagaaagaaatgtagaatgtagcagtggtgtggagacccgtggctgacaggtggtggtcttcatataggct
				gagggacaggctagatgcatgtcaagtggc
2071	3670551	—	NO	gagctccagggatatctcttctgcacattcttccagagcagtgcatctctcttctggttgtttgtacacccttcttttactctccttattatcctctcccatgttcattca
				gtacatacttagtgagtgttcaccagatgcttagcacctggggtatac
2072	3729159	DHX40	NO	gcctatggcaggattctttcttgaattaatattaatccttaaattgatttttctgggattatacaaattcctttttatataaaagtatattgtttaaaacagtagctatagc
				cattaaccaaaggacagatgatatatatatatatgatatatatatatatataagttcttttttagctgtacctacgtacttatatcagcaccatgtatgtaggtgtgata
				gtactttcaaacagcgcctccacctggcctactctgttatttccacctgtttgggtagggccatttaacttccattatgccaaacttgggatgggattttcgaagca
				gacaacactatttcatcgtgtttcaaattggaaccttgaggctagttagtatcacact
2073	2969482	CDC2L6	YES	tgtatttgccggctgccagattccataccccaaacgagaattccttaatgaagat
2074	3040116	SNX13	YES	tggcaaccttattttactacacgcattgtagatgactttggcacacacttacgagtattcagaaaggctcaaca
2075	3819122	LOC100129391	YES	gaggtggctagaaaacggcaagaac
2076	2359763	—	NO	acctgcgtcacaccctggctagtgacccagtcagacgtgctggggaccctggctgaccacctgtaccaggggcaaggaaggaaggagaggggagcatt
				gtgaagcagggcaggatgactcttgaaggtggagacaggccctggacagctctgggacccttaatggtggcagc
2077	2969302	WASF1	YES	ggtttgatagaaaatcgccctcagtcaccagctacaggcagaacacctgtgtttgt
2078	2330410	C1orf113	NO	gaagctggtcccacggaaagtggtatctcgggaatcag
2079	3265461	FAM160B1	NO	tctaggtggggaactgactgataacccttggcagcaatcaaagtgccagtggctcctcgatgtttacatttttttctattttgttcagtcttttgttttaaatgattcta
				aagagattaaagaaaacagagttttaaatgtcctatttacatgttaaaggatttggggaaattgggtatgtatgtgaatgggtgtacatgtaggaacctgtagttc
				agcaaagctgcgctgggcacagcatgcttgtacttgattgacaaaatcgtgtttgccagtccactttctatttttcctttaagtgatgctgatcactcaaataatgct
				tttaagctattgtttgtttttatttgacatgttaagccgcagcactttcttcttcatctttccatttactgatatttgggggaacaggctatcaaaggttccggcttgaag
				ggaactgtcactac
2080	3735093	LOC643008	NO	gccaccgacttcgtgcaggagatgcgc
2081	2402500	PAFAH2	YES	ggcaacattgacatgagccgtgtggctgtgatgggacattcatttggaggggccacagctatt
2082	3552152	MEG3	YES	tcttcaacccactgcttcctgactcgctctactccgtggaagcacgctcaca
2083	2736402	—	NO	attataaggtatgatatggcttcccaattgtcaaagaattaaaatgctcattaggagaggagtgactgcttctccctttagtagaaaaacaattcaaactcaggtt
				accaattacaatacacaaactaaaacagttatgttgagccgggaaaccgtcttcttgtaggctatcttctagcaccaaataatgcccacatgatttctggctgaa
				ggcca
2084	2751960	—	NO	gcttccttcgtgaattctaaccgtaccgttactgtgtttgaggatcactggcagccgagctctgagtggggaactgagataagaaaggtgttgtcatgataaca
				cctggacagctgcatcccacagactatgggagtgccaggaaactggctacctcacagcagagtagagaaaatggaaataaacacaaatataagcttttcag
				tgagctgtgggtcagagaaggccacaagtggtctggcagatcatggtgcagctctttgtttcatgagctacgtgcagcagtagtttttatgagctctttttgtag
				ctttccagccctaggattcagccatggtaa
2085	3024231	—	NO	tgcccagaaacgaccattttggacaatctcatccagttttacgcttgttttattcagaaagagaatcacctatcctcttcacatc
2086	2928814	—	NO	taaggaaattgggttgtcaccactggctttgagtaattcgttttgtctatgcaagctgtcttcatacgaaaaaggttttcatactatatccagtccc
2087	3166955	NFX1	YES	gttgaagtcgaaacatcccactggacat
2088	3829651	KIAA0355	YES	cctgactgtggtgcaagtccatttccagtttttgactcatgcgttacagaaggtccagccggtggctcactcttgctttgctgaggtcatcgtgcc
2089	3709186	JMJD3	YES	gtcaggcagctgtaagcggcgacagaag
2090	2947628	—	NO	ctgttgacttcagagtcgagtgtgag
2091	3820638	SLC44A2	NO	cccagtgatggccacgtcttgtttctagaatcccttcctttgcacaagccatattctgaactcttaattccttcccttaacttcaatccctatgtctcctgtcctacctc
				atggttttcctggccccacacctgatgctcagagcccactgtgaacccctggtgcctcttttggactcggttc
2092	3823661	AP1M1	NO	cagcctcagactttttcccactgagggtccagagagcggggccacgtgtcacccacgtctgcgcttggtcacccgtcctccccaccctgtgtgtgtttatgtc
				atagttacattaa
2093	4038647	—	NO	aggtctccgctttcctggaaatccagaccc
2094	2543897	—	NO	agctctgggtgagacttgtcttccgggggctg
2095	2353902	—	NO	ctctgattaggtcttgtgcccattgttgaaccaaatgctgtgcttaggaggatgggacatgttctttttgttttgcttagttagggcctggctctggagccaggaga
				ggggaggaggaaatgttgctggatgtaagttagcactgatactaattattctaacaatgattaatagttagaatggctgggtgcagtggcacatagtcccagct
				ccgcaggaggttgagatgggaggatcgcctggggccaggagtccaaggctatggggcaccatgatcatga
2096	3190953	PPP2R4	YES	cactttgtggatgagaaggccgtgaatgagaaccacaaggact
2097	3922999	PKNOX1	YES	gcgcccggccgagaatgacatcttaa
2098	3701615	—	NO	atggacagcttcaaagggcagtttgggggtttctgtttattttcctgtatgttctggtcacctcaatcatctaaccagaagaactggcccaaaattaggcacaag
				aaaaaaggaaaaagtctagccctgccacataactcctggaactggttgcagaaactgaac
2099	2528729	—	NO	gggaagacacgaagggagggcgctg
2100	3188305	—	NO	ggatagcttctattgtggacgtggaatcc
2101	3578798	—	NO	agatctactcctggatgcgggtacaggacagcatccccagactgtttgtaaagtctcatgtgatacatggagggcaggcct
2102	3810041	—	NO	agcagaagcaaacgggggtgtctcaggagggggccccgtttccttcttgtaaagctgctcccacccacagccacactccattcagtcaggtttatgtgctgtt
				cttccttgtcccttatgaggtagaaccatcaccttgcgtgcaaagcagctta
2103	2520084	MGC13057	NO	ggtgtctgtcggtctttgcttgtcagctgt
2104	2615285	—	NO	gtgtttgtgctcaatgtaagagcaaggaaggtgcgggaagatgagggggatgaggcgcaggagtacagggctgttattca
2105	2676383	NEK4	YES	tggtagagtggtttgtacagatcgccatggctttgcag
2106	3337536	—	NO	aggcttcttgcacaggcagaaggggct
2107	3670582	—	NO	tacgtgcccaagaatcaatccaatccaactgataacattttctctgaagatagctgcctcttcaaatactggtacagagattcaagaagctgtaccacagacca
				tcagtt
2108	2359853	—	NO	cccatttttcattaggtccaggtgtatccaaatgttgcca
2109	3349998	—	NO	tgatgtggccccgattgcagaattgagttggaggctgaagcatgtgagctctgatccttgcc
2110	3431977	—	NO	cttccctctggaagactaacatgtactgctgaagtcttgttcagtgtccttctagccccagactttgcagcctaccaacatggactgagacagggaaagcgtg
				ggcaagtgagttccatactctaattttcctacagaagcatcctaagtggtgtgtgggttctcagatcaagtcacaaacacattcacagcccatgatatcgtacaa
				cactactttttagttcaaattaattatgagtaacaacagactatctgccaaaatagggagctgca
2111	2482372	ACYP2	YES	agctaggaaaataggagtggttggctg
2112	2619332	SS18L2	YES	cattgcagatgccagtccaaccagcac
2113	3810037	—	NO	cccgtggctctaaaagtattatccgaaatcaaccagtcacccctttcaccttctctcagtttaaaaatggatccagtgcatacccaatag
2114	2944959	—	NO	gtaggaatcaaacatagcgccatctatctgctttttatattatcctacactattttaaaaactgctcaacagtcttatacagaaatctttaaaagatagacaggataa
				catgctatattaaccccaccattgaaataatccaacaccatcacgattccgattaagagaagaaaaaaatcttttttttttctttttttttctttttttctttttttttttccga
				aaccactcgccctccactgactgcccctgtaccacatcaaacagtctcctctcctccacgcctccggggtctgggaagtctcacctcactgatttc

TABLE 4
Differentially expressed RNA transcripts used to plot hierarchical
clustering and expression matrix (‘heat map’) in FIG. 1B. The 526
RNA transcripts represent a subset of the differentially expressed
transcripts (Table 3) between patients in the three clinical status
groups (i.e., ‘SYS’, ‘PSA’ and ‘NED’) disease using linear
regression and a p-value cut-off of p < 0.01. Weighting factors were
from the regression coeffecient values; positive and negative values
indicated transcripts correlated to increased expression in ‘SYS’
and ‘NED’ disease, respectively with intermediate expression
values in the ‘PSA’ disease group. Weighting factors were used
to derive 526-metagene values in FIG. 2.

	SEQ
	ID
	No	Weights

	1	−6.08
	2	−5.71
	3	−5.68
	4	−5.39
	5	−5.26
	6	−4.84
	7	−4.7
	8	−4.68
	9	−4.66
	10	−4.55
	11	−4.53
	12	−4.47
	13	−4.4
	14	−4.37
	15	−4.32
	16	−4.27
	17	−4.23
	18	−4.2
	19	−4.18
	20	−4.1
	21	−4.09
	22	−4.06
	23	−4.03
	24	−4.02
	25	−4.01
	26	−4
	27	−3.96
	28	−3.95
	29	−3.95
	30	−3.95
	31	−3.95
	32	−3.92
	33	−3.91
	34	−3.88
	35	−3.86
	36	−3.85
	37	−3.8
	38	−3.8
	39	−3.79
	40	−3.74
	41	−3.73
	42	−3.73
	43	−3.71
	44	−3.7
	45	−3.7
	46	−3.7
	47	−3.68
	48	−3.67
	49	−3.66
	50	−3.66
	51	−3.65
	52	−3.65
	53	−3.64
	54	−3.64
	55	−3.63
	56	−3.62
	57	−3.6
	58	−3.6
	59	−3.59
	60	−3.58
	61	−3.58
	62	−3.58
	63	−3.58
	64	−3.58
	65	−3.57
	66	−3.57
	67	−3.57
	68	−3.55
	69	−3.52
	70	−3.51
	71	−3.5
	72	−3.5
	73	−3.49
	74	−3.48
	75	−3.48
	76	−3.47
	77	−3.47
	78	−3.47
	79	−3.47
	80	−3.46
	81	−3.45
	82	−3.45
	83	−3.44
	84	−3.43
	85	−3.43
	86	−3.43
	87	−3.43
	88	−3.42
	89	−3.41
	90	−3.41
	91	−3.4
	92	−3.4
	93	−3.39
	94	−3.38
	95	−3.36
	96	−3.36
	97	−3.36
	98	−3.36
	99	−3.35
	100	−3.35
	101	−3.35
	102	−3.34
	103	−3.34
	104	−3.34
	105	−3.33
	106	−3.33
	107	−3.32
	108	−3.32
	109	−3.31
	110	−3.31
	111	−3.3
	112	−3.3
	113	−3.3
	114	−3.3
	115	−3.27
	116	−3.27
	117	−3.26
	118	−3.26
	119	−3.26
	120	−3.25
	121	−3.25
	122	−3.24
	123	−3.24
	124	−3.23
	125	−3.23
	126	−3.22
	127	−3.22
	128	−3.22
	129	−3.22
	130	−3.22
	131	−3.21
	132	−3.21
	133	−3.21
	134	−3.2
	135	−3.19
	136	−3.19
	137	−3.19
	138	−3.19
	139	−3.18
	140	−3.17
	141	−3.17
	142	−3.16
	143	−3.16
	144	−3.15
	145	−3.14
	146	−3.14
	147	−3.13
	148	−3.13
	149	−3.12
	150	−3.12
	151	−3.11
	152	−3.11
	153	−3.11
	154	−3.11
	155	−3.1
	156	−3.1
	157	−3.09
	158	−3.09
	159	−3.09
	160	−3.08
	161	−3.08
	162	−3.08
	163	−3.07
	164	−3.07
	165	−3.07
	166	−3.07
	167	−3.07
	168	−3.07
	169	−3.06
	170	−3.06
	171	−3.06
	172	−3.05
	173	−3.05
	174	−3.05
	175	−3.05
	176	−3.04
	177	−3.03
	178	−3.03
	179	−3.03
	180	−3.02
	181	−3.02
	182	−3.02
	183	−3.01
	184	−3.01
	185	−3
	186	−3
	187	−2.96
	188	−2.96
	189	−2.96
	190	−2.95
	191	−2.95
	192	−2.95
	193	−2.94
	194	−2.94
	195	−2.94
	196	−2.93
	197	−2.92
	198	−2.92
	199	−2.92
	200	−2.92
	201	−2.91
	202	−2.91
	203	−2.9
	204	−2.89
	205	−2.89
	206	−2.88
	207	−2.88
	208	−2.87
	209	−2.87
	210	−2.87
	211	−2.86
	212	−2.85
	213	−2.85
	914	5.32
	915	5.27
	916	4.82
	917	4.64
	918	4.59
	919	4.54
	920	4.49
	921	4.45
	922	4.43
	923	4.38
	924	4.38
	925	4.36
	926	4.36
	927	4.33
	928	4.27
	929	4.27
	930	4.18
	931	4.17
	932	4.13
	933	4.12
	934	4.08
	935	4.08
	936	4.07
	937	4.07
	938	4.04
	939	4.03
	940	4.03
	941	4.02
	942	4.02
	943	4.01
	944	3.97
	945	3.95
	946	3.95
	947	3.95
	948	3.95
	949	3.92
	950	3.92
	951	3.9
	952	3.89
	953	3.88
	954	3.84
	955	3.84
	956	3.83
	957	3.8
	958	3.8
	959	3.8
	960	3.79
	961	3.77
	962	3.76
	963	3.75
	964	3.74
	965	3.72
	966	3.71
	967	3.71
	968	3.71
	969	3.7
	970	3.7
	971	3.69
	972	3.69
	973	3.68
	974	3.67
	975	3.66
	976	3.65
	977	3.64
	978	3.63
	979	3.62
	980	3.62
	981	3.61
	982	3.61
	983	3.6
	984	3.6
	985	3.59
	986	3.59
	987	3.58
	988	3.58
	989	3.57
	990	3.57
	991	3.56
	992	3.56
	993	3.55
	994	3.55
	995	3.55
	996	3.55
	997	3.54
	998	3.54
	999	3.54
	1000	3.54
	1001	3.54
	1002	3.53
	1003	3.53
	1004	3.53
	1005	3.53
	1006	3.53
	1007	3.53
	1008	3.52
	1009	3.52
	1010	3.51
	1011	3.51
	1012	3.5
	1013	3.49
	1014	3.49
	1015	3.48
	1016	3.48
	1017	3.48
	1018	3.48
	1019	3.47
	1020	3.46
	1021	3.45
	1022	3.45
	1023	3.44
	1024	3.44
	1025	3.44
	1026	3.43
	1027	3.43
	1028	3.42
	1029	3.41
	1030	3.41
	1031	3.41
	1032	3.41
	1033	3.4
	1034	3.4
	1035	3.4
	1036	3.39
	1037	3.39
	1038	3.39
	1039	3.39
	1040	3.38
	1041	3.38
	1042	3.38
	1043	3.38
	1044	3.37
	1045	3.37
	1046	3.37
	1047	3.36
	1048	3.35
	1049	3.35
	1050	3.35
	1051	3.34
	1052	3.34
	1053	3.33
	1054	3.33
	1055	3.33
	1056	3.32
	1057	3.31
	1058	3.31
	1059	3.31
	1060	3.31
	1061	3.3
	1062	3.3
	1063	3.3
	1064	3.29
	1065	3.29
	1066	3.29
	1067	3.28
	1068	3.27
	1069	3.27
	1070	3.27
	1071	3.27
	1072	3.26
	1073	3.26
	1074	3.25
	1075	3.24
	1076	3.24
	1077	3.24
	1078	3.22
	1079	3.22
	1080	3.22
	1081	3.21
	1082	3.21
	1083	3.2
	1084	3.2
	1085	3.2
	1086	3.2
	1087	3.2
	1088	3.19
	1089	3.19
	1090	3.19
	1091	3.19
	1092	3.19
	1093	3.18
	1094	3.18
	1095	3.18
	1096	3.18
	1097	3.18
	1098	3.17
	1099	3.17
	1100	3.17
	1101	3.16
	1102	3.16
	1103	3.16
	1104	3.16
	1105	3.15
	1106	3.15
	1107	3.15
	1108	3.15
	1109	3.14
	1110	3.14
	1111	3.14
	1112	3.14
	1113	3.13
	1114	3.13
	1115	3.12
	1116	3.12
	1117	3.12
	1118	3.11
	1119	3.11
	1120	3.11
	1121	3.11
	1122	3.1
	1123	3.1
	1124	3.1
	1125	3.09
	1126	3.09
	1127	3.09
	1128	3.09
	1129	3.09
	1130	3.08
	1131	3.08
	1132	3.08
	1133	3.08
	1134	3.08
	1135	3.07
	1136	3.07
	1137	3.07
	1138	3.06
	1139	3.06
	1140	3.06
	1141	3.06
	1142	3.05
	1143	3.05
	1144	3.05
	1145	3.05
	1146	3.05
	1147	3.04
	1148	3.04
	1149	3.04
	1150	3.04
	1151	3.04
	1152	3.03
	1153	3.03
	1154	3.03
	1155	3.03
	1156	3.02
	1157	3.02
	1158	3.02
	1159	3.01
	1160	3.01
	1161	3.01
	1162	3.01
	1163	3.01
	1164	3.01
	1165	3
	1166	3
	1167	3
	1168	3
	1169	3
	1170	2.99
	1171	2.99
	1172	2.99
	1173	2.99
	1174	2.99
	1175	2.99
	1176	2.99
	1177	2.98
	1178	2.98
	1179	2.97
	1180	2.97
	1181	2.97
	1182	2.97
	1183	2.96
	1184	2.96
	1185	2.96
	1186	2.96
	1187	2.96
	1188	2.96
	1189	2.95
	1190	2.94
	1191	2.94
	1192	2.94
	1193	2.94
	1194	2.93
	1195	2.93
	1196	2.93
	1197	2.93
	1198	2.93
	1199	2.92
	1200	2.92
	1201	2.91
	1202	2.91
	1203	2.91
	1204	2.91
	1205	2.9
	1206	2.89
	1207	2.89
	1208	2.89
	1209	2.89
	1210	2.88
	1211	2.88
	1212	2.88
	1213	2.87
	1214	2.86
	1215	2.86
	1216	2.86
	1217	2.86
	1218	2.86
	1219	2.85
	1220	2.85
	1221	2.85
	1222	2.85
	1223	2.85
	1224	2.85
	1225	2.85
	1226	2.85

TABLE 5
Differentially expressed RNA transcripts used to plot
hierarchical clustering and expression matrix (‘heat map’)
in FIG. 1C. The 148 RNA transcripts represent a subset of the
most differentially expressed transcripts between patients with
clinically significant ‘recurrent’ (i.e., ‘SYS’) and ‘non-recurrent’
(i.e., ‘PSA’ and ‘NED’) disease. Weighting factors were
from the test statistic values; positive and negative values
indicated transcripts correlated to increased expression in
recurrent and non-recurrent disease, respectively. Weighting
factors were used to derive 148-metagene values, which were
converted by scaling and normalizing into ‘POP’ scores
depicted in FIG. 7.

	SEQ ID No	Weights

	1	−4.1
	2	−4.21
	3	−5.48
	4	−3.04
	6	−3.73
	8	−3.88
	14	−3.78
	20	−3.14
	32	−3.87
	33	−3.75
	36	−4.93
	42	−3.46
	45	−3.1
	46	−4.14
	60	−5.72
	63	−4.79
	65	−3.82
	66	−4.02
	67	−3.37
	69	−3.25
	79	−3.1
	86	−3.57
	88	−4.54
	96	−3.68
	100	−3.63
	104	−2.93
	115	−3.29
	129	−3.91
	130	−3.32
	181	−3.27
	182	−3.37
	187	−3.56
	189	−3.44
	194	−2.09
	217	−4
	225	−4.01
	241	−4.16
	265	−3.86
	280	−4.02
	293	−3.36
	295	−3.57
	334	−3.36
	355	−3.44
	387	−3.73
	400	−3.17
	437	−4.02
	445	−3.14
	460	−3.36
	468	−3
	536	−3.65
	592	−2.7
	596	−2.79
	684	−2.75
	915	3.78
	920	4.36
	923	3.23
	925	3.04
	926	4.61
	927	3.79
	933	3.24
	934	3.65
	935	3.64
	939	4.2
	941	4.14
	944	3.72
	945	4.03
	947	4.44
	949	3.77
	954	4.34
	960	3.54
	968	3.84
	970	3.5
	971	4.68
	974	3.63
	978	5.27
	986	2.59
	999	4.74
	1004	4.5
	1005	3.62
	1014	4.86
	1022	6.29
	1023	4.08
	1031	3.75
	1032	3.49
	1039	3.44
	1045	3.41
	1052	3.28
	1060	4.48
	1062	4.1
	1080	3.97
	1093	4.02
	1095	3.77
	1101	3.55
	1108	3.39
	1117	3.97
	1123	4.03
	1124	3.45
	1126	3.25
	1132	3.51
	1146	3.78
	1147	3.37
	1153	3.71
	1164	3.54
	1167	3.6
	1194	3.2
	1208	3.35
	1218	3.56
	1219	2.96
	1233	3.44
	1234	3.86
	1248	3.56
	1261	3.19
	1291	2.99
	1299	3.74
	1300	3.33
	1304	3.14
	1311	3.66
	1314	3.95
	1318	3.9
	1320	3.45
	1324	3.31
	1330	3.02
	1335	4.35
	1341	3.7
	1344	2.93
	1346	3.51
	1357	3.82
	1367	3.35
	1369	3.75
	1372	3.07
	1375	3.17
	1383	3.67
	1390	3.49
	1395	3.19
	1402	3.45
	1416	3.29
	1425	3.73
	1443	2.97
	1453	3.01
	1469	3.02
	1474	3.52
	1489	3.66
	1503	3.19
	1527	3.25
	1551	3.41
	1598	3.26
	1624	2.91
	1689	2.82

TABLE 6
Genes identified in a literature search as being correlated to
clinical outcome or prognosis in prostate cancer patients.
Indicated are the gene name and HNGC gene symbol.

Gene Name	Symbol
Aminoadipate-semialdehyde dehydrogenase	AASDH
ATP-binding cassette, sub-family A (ABC1), member 5	ABCA5
ATP-binding cassette, sub-family B (MDR/TAP), member 1	ABCB1
ATP-binding cassette, sub-family C (CFTR/MRP), member 2	ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 4	ABCC4
ATP-binding cassette, sub-family C (CFTR/MRP), member 5	ABCC5
ATP-binding cassette, sub-family G (WHITE), member 2	ABCG2
V-abl Abelson murine leukemia viral oncogene homolog 1	ABL1
Acetyl-Coenzyme A carboxylase alpha	ACACA
Acyl-Coenzyme A oxidase 1, palmitoyl	ACOX1
Acid phosphatase 2, lysosomal	ACP2
Acid phosphatase, prostate	ACPP
Actin, gamma 2, smooth muscle, enteric	ACTG2
Aspartoacylase (aminocyclase) 3	ACY3
AF4/FMR2 family, member 3	AFF3
AF4/FMR2 family, member 4	AFF4
Aryl hydrocarbon receptor	AHR
Absent in melanoma 2	AIM2
V-akt murine thymoma viral oncogene homolog 2	AKT2
Aminolevulinate, delta-, synthase 1	ALAS1
Activated leukocyte cell adhesion molecule	ALCAM
Aldehyde dehydrogenase 1 family, member A2	ALDH1A2
Anaplastic lymphoma kinase (Ki-1)	ALK
Arachidonate 12-lipoxygenase	ALOX12
Arachidonate 15-lipoxygenase, type B	ALOX15B
Alpha-methylacyl-CoA racemase	AMACR
Alanyl (membrane) aminopeptidase (aminopeptidase N,	ANPEP
aminopeptidase M, microsomal aminopeptidase, CD13,
p150)
Anthrax toxin receptor 2	ANTXR2
Annexin A2	ANXA2
APEX nuclease (multifunctional DNA repair enzyme) 1	APEX1
Androgen receptor (dihydrotestosterone receptor; testicular	AR
feminization; spinal and bulbar muscular atrophy; Kennedy
disease)
V-raf murine sarcoma 3611 viral oncogene homolog	ARAF
Amphiregulin (schwannoma-derived growth factor)	AREG
AT rich interactive domain 4A (RBP1-like)	ARID4A
Armadillo repeat containing 5	ARMC5
Aryl hydrocarbon receptor nuclear translocator	ARNT
N-acylsphingosine amidohydrolase (acid ceramidase)-like	ASAHL
ATPase family, AAA domain containing 2	ATAD2
Activating transcription factor 1	ATF1
Ataxia telangiectasia mutated	ATM
Atrophin 1	ATN1
ATP synthase, H+ transporting, mitochondrial F1 complex,	ATP5D
delta subunit
ATP synthase, H+ transporting, mitochondrial F0 complex,	ATP5J
subunit F6
Aurora kinase A	AURKA
Aurora kinase B	AURKB
AXL receptor tyrosine kinase	AXL
Beta-2-microglobulin	B2M
BCL2-antagonist of cell death	BAD
BAI1-associated protein 2-like 2	BAIAP2L2
BCL2-antagonist/killer 1	BAK1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal	BAP1
hydrolase)
BRCA1 associated RING domain 1	BARD1
B-cell CLL/lymphoma 2	BCL2
BCL2-like 1	BCL2L1
B-cell CLL/lymphoma 3	BCL3
Breakpoint cluster region	BCR
BCS1-like (yeast)	BCS1L
Biglycan	BGN
Baculoviral IAP repeat-containing 2	BIRC2
Baculoviral IAP repeat-containing 3	BIRC3
Baculoviral IAP repeat-containing 5 (survivin)	BIRC5
Baculoviral IAP repeat-containing 7 (livin)	BIRC7
Bloom syndrome	BLM
BMI1 polycomb ring finger oncogene	BMI1
Bone morphogenetic protein 4	BMP4
BolA homolog 2 (E. coli)	BOLA2
V-raf murine sarcoma viral oncogene homolog B1	BRAF
Breast cancer 1, early onset	BRCA1
Breast cancer 2, early onset	BRCA2
BTB (POZ) domain containing 14B	BTBD14B
Bruton agammaglobulinemia tyrosine kinase	BTK
BUB1 budding uninhibited by benzimidazoles 1 homolog	BUB1
(yeast)
Chromosome 15 open reading frame 33	C15orf33
Chromosome 17 open reading frame 56	C17orf56
Chromosome 17 open reading frame 57	C17orf57
Chromosome 1 open reading frame 115	C1orf115
Chromosome 1 open reading frame 77	C1orf77
Chromosome 2 open reading frame 33	C2orf33
Chromosome 2 open reading frame 37	C2orf37
Chromosome 3 open reading frame 14	C3orf14
Chromosome 8 open reading frame 32	C8orf32
Chromosome 8 open reading frame 53	C8orf53
Chromosome 8 open reading frame 76	C8orf76
Calcium channel, voltage-dependent, beta 4 subunit	CACNB4
Calmodulin binding transcription activator 1	CAMTA1
Caspase 2, apoptosis-related cysteine peptidase (neural	CASP2
precursor cell expressed, developmentally down-regulated
2)
Caspase 3, apoptosis-related cysteine peptidase	CASP3
Caspase 8, apoptosis-related cysteine peptidase	CASP8
Caveolin 1, caveolae protein, 22 kDa	CAV1
Cas-Br-M (murine) ecotropic retroviral transforming	CBL
sequence
Cholecystokinin	CCK
Cyclin A2	CCNA2
Cyclin B1	CCNB1
Cyclin C	CCNC
Cyclin D1	CCND1
Cyclin E1	CCNE1
Cyclin H	CCNH
CD34 molecule	CD34
CD38 molecule	CD38
CD40 molecule, TNF receptor superfamily member 5	CD40
CD44 molecule (Indian blood group)	CD44
CD59 molecule, complement regulatory protein	CD59
CD69 molecule	CD69
CD9 molecule	CD9
Cell division cycle 2, G1 to S and G2 to M	CDC2
Cell division cycle 25 homolog A (S. pombe)	CDC25A
Cell division cycle 25 homolog B (S. pombe)	CDC25B
Cell division cycle 25 homolog C (S. pombe)	CDC25C
CDC42 effector protein (Rho GTPase binding) 5	CDC42EP5
Cadherin 1, type 1, E-cadherin (epithelial)	CDH1
Cadherin 11, type 2, OB-cadherin (osteoblast)	CDH11
Cadherin 13, H-cadherin (heart)	CDH13
Cyclin-dependent kinase 10	CDK10
Cyclin-dependent kinase 2	CDK2
Cyclin-dependent kinase 4	CDK4
Cyclin-dependent kinase 6	CDK6
Cyclin-dependent kinase 7	CDK7
Cyclin-dependent kinase 9	CDK9
Cyclin-dependent kinase inhibitor 1A (p21, Cip1)	CDKN1A
Cyclin-dependent kinase inhibitor 1B (p27, Kip1)	CDKN1B
CDKN2A interacting protein N-terminal like	CDKN2AIPNL
Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	CDKN2C
Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual	CDKN3
specificity phosphatase)
CCAAT/enhancer binding protein (C/EBP), alpha	CEBPA
Centrosomal protein 135 kDa	CEP135
Centrosomal protein 70 kDa	CEP70
Chromatin assembly factor 1, subunit A (p150)	CHAF1A
CHK1 checkpoint homolog (S. pombe)	CHEK1
Chromogranin A (parathyroid secretory protein 1)	CHGA
Chromatin accessibility complex 1	CHRAC1
Ceroid-lipofuscinosis, neuronal 5	CLN5
Clusterin	CLU
Calponin 1, basic, smooth muscle	CNN1
Cannabinoid receptor 1 (brain)	CNR1
Collagen, type XVIII, alpha 1	COL18A1
Collagen, type I, alpha 1	COL1A1
Collagen, type IV, alpha 3 (Goodpasture antigen)	COL4A3
COMM domain containing 5	COMMD5
Catechol-O-methyltransferase	COMT
Coatomer protein complex, subunit beta 2 (beta prime)	COPB2
COP9 constitutive photomorphogenic homolog subunit 5	COPS5
(Arabidopsis)
Cytoplasmic polyadenylation element binding protein 3	CPEB3
Cysteine-rich secretory protein 3	CRISP3
V-crk sarcoma virus CT10 oncogene homolog (avian)	CRK
V-crk sarcoma virus CT10 oncogene homolog (avian)-like	CRKL
Colony stimulating factor 1 receptor, formerly McDonough	CSF1R
feline sarcoma viral (v-fms) oncogene homolog
Colony stimulating factor 2 (granulocyte-macrophage)	CSF2
Colony stimulating factor 3 receptor (granulocyte)	CSF3R
C-src tyrosine kinase	CSK
Cystatin B (stefin B)	CSTB
Connective tissue growth factor	CTGF
Collagen triple helix repeat containing 1	CTHRC1
Catenin (cadherin-associated protein), alpha 1, 102 kDa	CTNNA1
Catenin (cadherin-associated protein), beta 1, 88 kDa	CTNNB1
Cathepsin B	CTSB
Cathepsin L1	CTSL1
Cortactin	CTTN
Cullin 2	CUL2
Chemokine (C—X—C motif) ligand 14	CXCL14
Chemokine (C—X—C motif) ligand 9	CXCL9
Chromosome X open reading frame 41	CXorf41
Cytochrome b5 type A (microsomal)	CYB5A
Cytoplasmic FMR1 interacting protein 1	CYFIP1
Cytochrome P450, family 27, subfamily A, polypeptide 1	CYP27A1
Cytochrome P450, family 2, subfamily C, polypeptide 9	CYP2C9
Cytochrome P450, family 3, subfamily A, polypeptide 5	CYP3A5
Disabled homolog 2, mitogen-responsive phosphoprotein	DAB2
(Drosophila)
Death associated protein 3	DAP3
Death-associated protein kinase 1	DAPK1
Deleted in colorectal carcinoma	DCC
Dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-	DCI
Coenzyme A isomerase)
Decorin	DCN
Dynactin 2 (p50)	DCTN2
Damage-specific DNA binding protein 2, 48 kDa	DDB2
Dopa decarboxylase (aromatic L-amino acid decarboxylase)	DDC
Development and differentiation enhancing factor 1	DDEF1
DNA-damage-inducible transcript 3	DDIT3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	DDX6
2,4-dienoyl CoA reductase 2, peroxisomal	DECR2
DEK oncogene (DNA binding)	DEK
DENN/MADD domain containing 3	DENND3
DEP domain containing 1B	DEPDC1B
DEP domain containing 6	DEPDC6
Diacylglycerol kinase, alpha 80 kDa	DGKA
DEAH (Asp-Glu-Ala-His) box polypeptide 9	DHX9
Deiodinase, iodothyronine, type II	DIO2
DIRAS family, GTP-binding RAS-like 3	DIRAS3
Dyskeratosis congenita 1, dyskerin	DKC1
DKEZP564O0823 protein	DKEZP564O0823
Discs, large homolog 3 (neuroendocrine-dlg, Drosophila)	DLG3
Discs, large (Drosophila) homolog-associated protein 1	DLGAP1
Deleted in malignant brain tumors 1	DMBT1
Dedicator of cytokinesis 5	DOCK5
Desmoplakin	DSP
E2F transcription factor 1	E2F1
E2F transcription factor 2	E2F2
E2F transcription factor 3	E2F3
E2F transcription factor 4, p107/p130-binding	E2F4
Endothelial differentiation, lysophosphatidic acid G-protein-	EDG7
coupled receptor, 7
Endothelin receptor type B	EDNRB
Eukaryotic translation elongation factor 1 alpha 1	EEF1A1
Embryonal Fyn-associated substrate	EFS
Epidermal growth factor (beta-urogastrone)	EGF
Epidermal growth factor receptor (erythroblastic leukemia	EGFR
viral (v-erb-b) oncogene homolog, avian)
Early growth response 2 (Krox-20 homolog, Drosophila)	EGR2
Early growth response 3	EGR3
Euchromatic histone-lysine N-methyltransferase 1	EHMT1
Euchromatic histone-lysine N-methyltransferase 2	EHMT2
Eukaryotic translation initiation factor 2-alpha kinase 2	EIF2AK2
Eukaryotic translation initiation factor 3, subunit H	EIF3H
ELK1, member of ETS oncogene family	ELK1
ELK3, ETS-domain protein (SRF accessory protein 2)	ELK3
Elongation factor RNA polymerase II	ELL
Elongation factor RNA polymerase II-like 3	ELL3
Epithelial membrane protein 2	EMP2
Ectonucleotide pyrophosphatase/phosphodiesterase 2	ENPP2
(autotaxin)
Enhancer of yellow 2 homolog (Drosophila)	ENY2
EPH receptor A1	EPHA1
EPH receptor B4	EPHB4
Epsin 1	EPN1
Erythropoietin	EPO
Epidermal growth factor receptor pathway substrate 15	EPS15
Epidermal growth factor receptor pathway substrate 8	EPS8
V-erb-b2 erythroblastic leukemia viral oncogene homolog 2,	ERBB2
neuro/glioblastoma derived oncogene homolog (avian)
V-erb-b2 erythroblastic leukemia viral oncogene homolog 3	ERBB3
(avian)
V-erb-a erythroblastic leukemia viral oncogene homolog 4	ERBB4
(avian)
Excision repair cross-complementing rodent repair	ERCC1
deficiency, complementation group 1 (includes overlapping
antisense sequence)
Excision repair cross-complementing rodent repair	ERCC2
deficiency, complementation group 2 (xeroderma
pigmentosum D)
Excision repair cross-complementing rodent repair	ERCC3
deficiency, complementation group 3 (xeroderma
pigmentosum group B complementing)
Excision repair cross-complementing rodent repair	ERCC4
deficiency, complementation group 4
Excision repair cross-complementing rodent repair	ERCC5
deficiency, complementation group 5 (xeroderma
pigmentosum, complementation group G (Cockayne
syndrome))
Excision repair cross-complementing rodent repair	ERCC6
deficiency, complementation group 6
V-ets erythroblastosis virus E26 oncogene homolog (avian)	ERG
Endoplasmic reticulum to nucleus signaling 2	ERN2
Estrogen receptor 1	ESR1
Estrogen receptor 2 (ER beta)	ESR2
V-ets erythroblastosis virus E26 oncogene homolog 1	ETS1
(avian)
V-ets erythroblastosis virus E26 oncogene homolog 2	ETS2
(avian)
Ets variant gene 1	ETV1
Ets variant gene 4 (E1A enhancer binding protein, E1AF)	ETV4
Ets variant gene 6 (TEL oncogene)	ETV6
Even-skipped homeobox 1	EVX1
Exocyst complex component 2	EXOC2
Exostoses (multiple) 1	EXT1
Exostoses (multiple) 2	EXT2
Enhancer of zeste homolog 2 (Drosophila)	EZH2
Ezrin	EZR
Coagulation factor II (thrombin) receptor	F2R
Coagulation factor V (proaccelerin, labile factor)	F5
Family with sequence similarity 114, member A1	FAM114A1
Family with sequence similarity 13, member C1	FAM13C1
Family with sequence similarity 49, member B	FAM49B
Family with sequence similarity 84, member B	FAM84B
Family with sequence similarity 8, member A1	FAM8A1
Fanconi anemia, complementation group A	FANCA
Fanconi anemia, complementation group G	FANCG
Fas (TNF receptor superfamily, member 6)	FAS
Fas ligand (TNF superfamily, member 6)	FASLG
Fatty acid synthase	FASN
Fibulin 1	FBLN1
F-box protein 32	FBXO32
F-box and WD repeat domain containing 11	FBXW11
Farnesyl diphosphate synthase (farnesyl pyrophosphate	FDPS
synthetase, dimethylallyltranstransferase,
geranyltranstransferase)
Fer (fps/fes related) tyrosine kinase (phosphoprotein	FER
NCP94)
Feline sarcoma oncogene	FES
FEV (ETS oncogene family)	FEV
Fibroblast growth factor 12	FGF12
Fibroblast growth factor 3 (murine mammary tumor virus	FGF3
integration site (v-int-2) oncogene homolog)
Fibroblast growth factor 5	FGF5
Fibroblast growth factor 8 (androgen-induced)	FGF8
Fibroblast growth factor 9 (glia-activating factor)	FGF9
Fibroblast growth factor receptor 1 (fms-related tyrosine	FGFR1
kinase 2, Pfeiffer syndrome)
Fibroblast growth factor receptor 2 (bacteria-expressed	FGFR2
kinase, keratinocyte growth factor receptor, craniofacial
dysostosis 1, Crouzon syndrome, Pfeiffer syndrome,
Jackson-Weiss syndrome)
Fibroblast growth factor receptor 4	FGFR4
Fragile histidine triad gene	FHIT
Folliculin	FLCN
Friend leukemia virus integration 1	FLI1
Hypothetical protein FLJ90709	FLJ90709
Fms-related tyrosine kinase 1 (vascular endothelial growth	FLT1
factor/vascular permeability factor receptor)
Fms-related tyrosine kinase 4	FLT4
Flavin containing monooxygenase 5	FMO5
Fibromodulin	FMOD
Folate hydrolase (prostate-specific membrane antigen) 1	FOLH1
Folate receptor 1 (adult)	FOLR1
V-fos FBJ murine osteosarcoma viral oncogene homolog	FOS
FK506 binding protein 12-rapamycin associated protein 1	FRAP1
Frizzled-related protein	FRZB
FYN oncogene related to SRC, FGR, YES	FYN
Frizzled homolog 7 (Drosophila)	FZD7
Gamma-aminobutyric acid (GABA) A receptor, gamma 2	GABRG2
Growth arrest and DNA-damage-inducible, alpha	GADD45A
G protein beta subunit-like	GBL
Gastrulation brain homeobox 2	GBX2
Ganglioside-induced differentiation-associated protein 1	GDAP1
Growth differentiation factor 15	GDF15
Glioma-associated oncogene homolog 1 (zinc finger protein)	GLI1
Glutaredoxin 2	GLRX2
GPI anchored molecule like protein	GML
Geminin, DNA replication inhibitor	GMNN
Guanine nucleotide binding protein (G protein), alpha 15	GNA15
GNAS complex locus	GNAS
Guanine nucleotide binding protein (G protein), beta	GNB1
polypeptide 1
Glucosamine (UDP-N-acetyl)-2-epimerase/N-	GNE
acetylmannosamine kinase
N-acetylglucosamine-1-phosphate transferase, alpha and	GNPTAB
beta subunits
Golgi membrane protein 1	GOLM1
Golgi-localized protein	GOLSYN
G protein-coupled receptor 137B	GPR137B
Growth factor receptor-bound protein 2	GRB2
Growth factor receptor-bound protein 7	GRB7
Gremlin 2, cysteine knot superfamily, homolog (Xenopus	GREM2
laevis)
Gastrin-releasing peptide receptor	GRPR
Glycogen synthase kinase 3 alpha	GSK3A
Glutathione S-transferase pi	GSTP1
Glucuronidase, beta	GUSB
H1 histone family, member X	H1FX
Heparin-binding EGF-like growth factor	HBEGF
HCCA2 protein	HCCA2
Host cell factor C1 (VP16-accessory protein)	HCFC1
Hemopoietic cell kinase	HCK
Histone deacetylase 1	HDAC1
Histone deacetylase 7A	HDAC7A
Hepatoma-derived growth factor (high-mobility group	HDGF
protein 1-like)
HECT, C2 and WW domain containing E3 ubiquitin protein	HECW2
ligase 2
Hypoxia-inducible factor 1, alpha subunit (basic helix-loop-	HIF1A
helix transcription factor)
Hydroxymethylbilane synthase	HMBS
3-hydroxy-3-methylglutaryl-Coenzyme A reductase	HMGCR
Hyaluronan-mediated motility receptor (RHAMM)	HMMR
Hook homolog 1 (Drosophila)	HOOK1
Homeobox A9	HOXA9
Homeobox C4	HOXC4
Hepsin (transmembrane protease, serine 1)	HPN
Hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan	HPRT1
syndrome)
V-Ha-ras Harvey rat sarcoma viral oncogene homolog	HRAS
Hydroxysteroid (17-beta) dehydrogenase 4	HSD17B4
Hydroxysteroid (17-beta) dehydrogenase 6 homolog	HSD17B6
(mouse)
Heat shock transcription factor 4	HSF4
Heat shock 27 kDa protein 1	HSPB1
Intercellular adhesion molecule 1 (CD54), human rhinovirus	ICAM1
receptor
Immediate early response 3	IER3
Interferon, gamma	IFNG
Interferon gamma receptor 1	IFNGR1
Insulin-like growth factor 1 (somatomedin C)	IGF1
Insulin-like growth factor 1 receptor	IGF1R
Insulin-like growth factor 2 receptor	IGF2R
Insulin-like growth factor binding protein 1	IGFBP1
Insulin-like growth factor binding protein 2, 36 kDa	IGFBP2
Insulin-like growth factor binding protein 3	IGFBP3
Insulin-like growth factor binding protein 6	IGFBP6
IKAROS family zinc finger 1 (Ikaros)	IKZF1
Interleukin 11	IL11
Interleukin 12A (natural killer cell stimulatory factor 1,	IL12A
cytotoxic lymphocyte maturation factor 1, p35)
Interleukin 12B (natural killer cell stimulatory factor 2,	IL12B
cytotoxic lymphocyte maturation factor 2, p40)
Interleukin 13	IL13
Interleukin 1, beta	IL1B
Interleukin 2	IL2
Interleukin 3 (colony-stimulating factor, multiple)	IL3
Interleukin 4	IL4
Interleukin 6 (interferon, beta 2)	IL6
Interleukin 6 receptor	IL6R
Interleukin 8	IL8
Integrin-linked kinase	ILK
Inner membrane protein, mitochondrial (mitofilin)	IMMT
Inhibin, alpha	INHA
Inhibin, beta A	INHBA
Interferon regulatory factor 1	IRF1
Insulin receptor substrate 2	IRS2
ISL LIM homeobox 1	ISL1
Integrin, alpha V (vitronectin receptor, alpha polypeptide,	ITGAV
antigen CD51)
Integrin, beta 1 (fibronectin receptor, beta polypeptide,	ITGB1
antigen CD29 includes MDF2, MSK12)
Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	ITGB3
Integrin, beta 4	ITGB4
Inositol 1,4,5-trisphosphate 3-kinase A	ITPKA
Inositol 1,4,5-triphosphate receptor, type 1	ITPR1
Isovaleryl Coenzyme A dehydrogenase	IVD
Janus kinase 2 (a protein tyrosine kinase)	JAK2
Jumonji, AT rich interactive domain 1A	JARID1A
Jumonji domain containing 2B	JMJD2B
Jun oncogene	JUN
Jun B proto-oncogene	JUNB
Jun D proto-oncogene	JUND
Potassium channel regulator	KCNRG
Kinase insert domain receptor (a type III receptor tyrosine	KDR
kinase)
KH domain containing, RNA binding, signal transduction	KHDRBS3
associated 3
KIAA0196	KIAA0196
KIAA0922	KIAA0922
KIAA1324	KIAA1324
Kinesin family member C2	KIFC2
V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene	KIT
homolog
Kruppel-like factor 6	KLF6
Ketch domain containing 4	KLHDC4
Kallikrein-related peptidase 2	KLK2
Kallikrein-related peptidase 3	KLK3
Kallikrein-related peptidase 4	KLK4
Karyopherin (importin) beta 1	KPNB1
Keratin 15	KRT15
Keratin 5 (epidermolysis bullosa simplex, Dowling-	KRT5
Meara/Kobner/Weber-Cockayne types)
L1 cell adhesion molecule	L1CAM
Lymphocyte-specific protein tyrosine kinase	LCK
Lipocalin 2	LCN2
Leprecan-like 1	LEPREL1
Leucine-rich repeat-containing G protein-coupled receptor 4	LGR4
Ligase I, DNA, ATP-dependent	LIG1
Ligase III, DNA, ATP-dependent	LIG3
LIM domain only 1 (rhombotin 1)	LMO1
LIM domain only 2 (rhombotin-like 1)	LMO2
Poly (ADP-ribose) polymerase family, member 1	LOC649459
Lactotransferrin	LOC728320
Hypothetical protein BC008326	LOC89944
Lysyl oxidase	LOX
Leucine rich repeat containing 2	LRRC2
Limbic system-associated membrane protein	LSAMP
Latent transforming growth factor beta binding protein 2	LTBP2
Mal, T-cell differentiation protein-like	MALL
Mucosa associated lymphoid tissue lymphoma translocation	MALT1
gene 1
Monoamine oxidase B	MAOB
Mitogen-activated protein kinase kinase 6	MAP2K6
Mitogen-activated protein kinase kinase kinase 8	MAP3K8
Mitogen-activated protein kinase 1	MAPK1
Mitogen-activated protein kinase 10	MAPK10
Mitogen-activated protein kinase 14	MAPK14
MARCKS-like 1	MARCKSL1
MARVEL domain containing 3	MARVELD3
MAS1 oncogene	MAS1
Megakaryocyte-associated tyrosine kinase	MATK
Methyl-CpG binding domain protein 2	MBD2
Melanoma cell adhesion molecule	MCAM
Mutated in colorectal cancers	MCC
MCF.2 cell line derived transforming sequence	MCF2
Myeloid cell leukemia sequence 1 (BCL2-related)	MCL1
Minichromosome maintenance complex component 7	MCM7
Microcephalin 1	MCPH1
Mdm4, transformed 3T3 cell double minute 4, p53 binding	MDM4
protein (mouse)
Mediator complex subunit 30	MED30
Myocyte enhancer factor 2C	MEF2C
Meis homeobox 2	MEIS2
Multiple endocrine neoplasia I	MEN1
Met proto-oncogene (hepatocyte growth factor receptor)	MET
Methyltransferase 10 domain containing	METT10D
Hypothetical protein MGC15523	MGC15523
Antigen identified by monoclonal antibody Ki-67	MKI67
Myeloid leukemia factor 1	MLF1
Myeloid leukemia factor 2	MLF2
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	MLH1
Myeloid/lymphoid or mixed-lineage leukemia (trithorax	MLLT3
homolog, Drosophila); translocated to, 3
Myeloid/lymphoid or mixed-lineage leukemia (trithorax	MLLT4
homolog, Drosophila); translocated to, 4
Myeloid/lymphoid or mixed-lineage leukemia (trithorax	MLLT6
homolog, Drosophila); translocated to, 6
Matrix metallopeptidase 1 (interstitial collagenase)	MMP1
Matrix metallopeptidase 10 (stromelysin 2)	MMP10
Matrix metallopeptidase 14 (membrane-inserted)	MMP14
Matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase,	MMP2
72 kDa type IV collagenase)
Matrix metallopeptidase 3 (stromelysin 1, progelatinase)	MMP3
Matrix metallopeptidase 7 (matrilysin, uterine)	MMP7
Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase,	MMP9
92 kDa type IV collagenase)
V-mos Moloney murine sarcoma viral oncogene homolog	MOS
Membrane protein, palmitoylated 7 (MAGUK p55	MPP7
subfamily member 7)
Mitochondrial ribosomal protein L13	MRPL13
MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	MSH2
MutS homolog 3 (E. coli)	MSH3
MutS homolog 6 (E. coli)	MSH6
Microseminoprotein, beta-	MSMB
Macrophage scavenger receptor 1	MSR1
Macrophage stimulating 1 receptor (c-met-related tyrosine	MST1R
kinase)
Metastasis associated 1	MTA1
5,10-methylenetetrahydrofolate reductase (NADPH)	MTHFR
Myotrophin	MTPN
5-methyltetrahydrofolate-homocysteine methyltransferase	MTR
Metastasis suppressor 1	MTSS1
Mucin 1, cell surface associated	MUC1
MAX dimerization protein 1	MXD1
MAX interactor 1	MXI1
V-myb myeloblastosis viral oncogene homolog (avian)	MYB
V-myb myeloblastosis viral oncogene homolog (avian)-like 2	MYBL2
Myosin binding protein C, slow type	MYBPC1
V-myc myelocytomatosis viral oncogene homolog (avian)	MYC
V-myc myelocytomatosis viral related oncogene,	MYCN
neuroblastoma derived (avian)
Myosin, heavy chain 11, smooth muscle	MYH11
Myosin, light chain 9, regulatory	MYL9
Myosin, light chain kinase	MYLK
N-acetyltransferase 2 (arylamine N-acetyltransferase)	NAT2
Neuroblastoma, suppression of tumorigenicity 1	NBL1
Nibrin	NBN
Non-SMC condensin II complex, subunit D3	NCAPD3
N-myc downstream regulated gene 1	NDRG1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9,	NDUFB9
22 kDa
Neurofilament, heavy polypeptide 200 kDa	NEFH
Neogenin homolog 1 (chicken)	NEO1
Neuropilin (NRP) and tolloid (TLL)-like 2	NETO2
Neurofibromin 1 (neurofibromatosis, von Recklinghausen	NF1
disease, Watson disease)
Nuclear factor of kappa light polypeptide gene enhancer in	NFKB1
B-cells 1 (p105)
Nuclear factor of kappa light polypeptide gene enhancer in	NFKB2
B-cells 2 (p49/p100)
Nuclear factor of kappa light polypeptide gene enhancer in	NFKBIA
B-cells inhibitor, alpha
Nitric oxide synthase 3 (endothelial cell)	NOS3
Notch homolog 1, translocation-associated (Drosophila)	NOTCH1
Notch homolog 2 (Drosophila)	NOTCH2
Notch homolog 4 (Drosophila)	NOTCH4
Nephroblastoma overexpressed gene	NOV
NADPH oxidase 4	NOX4
Aminopeptidase-like 1	NPEPL1
NAD(P)H dehydrogenase, quinone 1	NQO1
Nuclear receptor subfamily 4, group A, member 1	NR4A1
Neuroblastoma RAS viral (v-ras) oncogene homolog	NRAS
Neuropilin 1	NRP1
Neurotrophic tyrosine kinase, receptor, type 1	NTRK1
Neurotrophic tyrosine kinase, receptor, type 2	NTRK2
Neurotrophic tyrosine kinase, receptor, type 3	NTRK3
Nuclear mitotic apparatus protein 1	NUMA1
Nucleoporin 98 kDa	NUP98
Ornithine decarboxylase antizyme 2	OAZ2
Oxysterol binding protein-like 9	OSBPL9
P antigen family, member 4 (prostate associated)	PAGE4
PAP associated domain containing 1	PAPD1
Par-3 partitioning defective 3 homolog (C. elegans)	PARD3
PAS domain containing serine/threonine kinase	PASK
Pre-B-cell leukemia homeobox 1	PBX1
Proliferating cell nuclear antigen	PCNA
PCTAIRE protein kinase 1	PCTK1
Platelet-derived growth factor alpha polypeptide	PDGFA
Platelet-derived growth factor receptor, alpha polypeptide	PDGFRA
Platelet-derived growth factor receptor, beta polypeptide	PDGFRB
Protein disulfide isomerase family A, member 5	PDIA5
PDZ and LIM domain 5	PDLIM5
Phosphatidylethanolamine-binding protein 4	PEBP4
Phosphatidylethanolamine N-methyltransferase	PEMT
Placental growth factor, vascular endothelial growth factor-	PGF
related protein
Phosphoglycerate kinase 1	PGK1
Progesterone receptor	PGR
Phosphatase and actin regulator 2	PHACTR2
PHD finger protein 20-like 1	PHF20L1
PHD finger protein 8	PHF8
Phytanoyl-CoA 2-hydroxylase interacting protein-like	PHYHIPL
Protein inhibitor of activated STAT, 2	PIAS2
Phosphoinositide-3-kinase, catalytic, alpha polypeptide	PIK3CA
Phosphoinositide-3-kinase, catalytic, delta polypeptide	PIK3CD
Polycystic kidney and hepatic disease 1 (autosomal	PKHD1L1
recessive)-like 1
Phospholipase A2, group IIA (platelets, synovial fluid)	PLA2G2A
Phospholipase A2, group VII (platelet-activating factor	PLA2G7
acetylhydrolase, plasma)
Pleiomorphic adenoma gene 1	PLAG1
Plasminogen activator, tissue	PLAT
Plasminogen activator, urokinase receptor	PLAUR
Plasminogen	PLG
Plexin domain containing 1	PLXDC1
Promyelocytic leukemia	PML
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	PMS1
Polymerase (RNA) I polypeptide C, 30 kDa	POLR1C
Periostin, osteoblast specific factor	POSTN
POU class 2 homeobox 1	POU2F1
Peroxisome proliferator-activated receptor delta	PPARD
Peroxisome proliferator-activated receptor gamma	PPARG
Protein phosphatase 2 (formerly 2A), regulatory subunit A,	PPP2R1B
beta isoform
Papillary renal cell carcinoma (translocation-associated)	PRCC
Peroxisomal proliferator-activated receptor A interacting	PRIC285
complex 285
Protein kinase, cAMP-dependent, regulatory, type I, alpha	PRKAR1A
(tissue specific extinguisher 1)
Protease, serine, 8	PRSS8
Prostate stem cell antigen	PSCA
Proteasome (prosome, macropain) 26S subunit, non-	PSMD1
ATPase, 1
Patched homolog 1 (Drosophila)	PTCH1
Patched homolog 2 (Drosophila)	PTCH2
Prostaglandin E receptor 3 (subtype EP3)	PTGER3
Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H	PTGS1
synthase and cyclooxygenase)
Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H	PTGS2
synthase and cyclooxygenase)
Parathyroid hormone-like hormone	PTHLH
PTK2 protein tyrosine kinase 2	PTK2
PTK7 protein tyrosine kinase 7	PTK7
Pleiotrophin (heparin binding growth factor 8, neurite	PTN
growth-promoting factor 1)
Protein tyrosine phosphatase type IVA, member 3	PTP4A3
Protein tyrosine phosphatase-like (proline instead of	PTPLB
catalytic arginine), member b
Protein tyrosine phosphatase, receptor type, F	PTPRF
Protein tyrosine phosphatase, receptor type, G	PTPRG
Protein tyrosine phosphatase, receptor type, H	PTPRH
Protein tyrosine phosphatase, receptor type, N polypeptide 2	PTPRN2
Poly-U binding splicing factor 60 KDa	PUF60
Purine-rich element binding protein A	PURA
Paxillin	PXN
Pyrroline-5-carboxylate reductase 1	PYCR1
Pyrroline-5-carboxylate reductase-like	PYCRL
Glutaminyl-tRNA synthetase	QARS
RAB32, member RAS oncogene family	RAB32
RAB8A, member RAS oncogene family	RAB8A
Rabaptin, RAB GTPase binding effector protein 2	RABEP2
RAD21 homolog (S. pombe)	RAD21
RAD23 homolog A (S. cerevisiae)	RAD23A
RAD50 homolog (S. cerevisiae)	RAD50
RAD54 homolog B (S. cerevisiae)	RAD54B
V-raf-1 murine leukemia viral oncogene homolog 1	RAF1
V-ral simian leukemia viral oncogene homolog B (ras	RALB
related; GTP binding protein)
RAP1, GTP-GDP dissociation stimulator 1	RAP1GDS1
RAP2A, member of RAS oncogene family	RAP2A
Retinoic acid receptor, alpha	RARA
RAS p21 protein activator (GTPase activating protein) 1	RASA1
Retinoblastoma 1 (including osteosarcoma)	RB1
Retinoblastoma binding protein 6	RBBP6
Retinoblastoma-like 2 (p130)	RBL2
Retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	RDH11
RecQ protein-like (DNA helicase Q1-like)	RECQL
RecQ protein-like 4	RECQL4
V-rel reticuloendotheliosis viral oncogene homolog (avian)	REL
V-rel reticuloendotheliosis viral oncogene homolog A,	RELA
nuclear factor of kappa light polypeptide gene enhancer in
B-cells 3, p65 (avian)
Ret proto-oncogene	RET
Ras homolog gene family, member A	RHOA
Ras homolog gene family, member H	RHOH
Receptor (TNFRSF)-interacting serine-threonine kinase 1	RIPK1
Relaxin 1	RLN1
Ring finger protein 139	RNF139
Ring finger protein 185	RNF185
V-ros UR2 sarcoma virus oncogene homolog 1 (avian)	ROS1
Replication protein A1, 70 kDa	RPA1
Ras-related GTP binding C	RRAGC
Related RAS viral (r-ras) oncogene homolog	RRAS
Rhabdoid tumor deletion region gene 1	RTDR1
S100 calcium binding protein A4	S100A4
Sterile alpha motif domain containing 12	SAMD12
Stearoyl-CoA desaturase 5	SCD5
Sodium channel and clathrin linker 1	SCLT1
Sodium channel, nonvoltage-gated 1 alpha	SCNN1A
Scribbled homolog (Drosophila)	SCRIB
Syndecan 2	SDC2
Succinate dehydrogenase complex, subunit B, iron sulfur	SDHB
(Ip)
Succinate dehydrogenase complex, subunit C, integral	SDHC
membrane protein, 15 kDa
SEC14-like 1 (S. cerevisiae)	SEC14L1
Sema domain, immunoglobulin domain (Ig), short basic	SEMA3F
domain, secreted, (semaphorin) 3F
Serpin peptidase inhibitor, clade B (ovalbumin), member 5	SERPINB5
Serpin peptidase inhibitor, clade I (neuroserpin), member 1	SERPINI1
Splicing factor 1	SF1
Secreted frizzled-related protein 4	SFRP4
SH3-domain binding protein 2	SH3BP2
SH3 domain containing ring finger 2	SH3RF2
Sonic hedgehog homolog (Drosophila)	SHH
Seven in absentia homolog 1 (Drosophila)	SIAH1
V-ski sarcoma viral oncogene homolog (avian)	SKI
SKI-like oncogene	SKIL
Solute carrier family 14 (urea transporter), member 1 (Kidd	SLC14A1
blood group)
Solute carrier family 20 (phosphate transporter), member 1	SLC20A1
Solute carrier family 22 (extraneuronal monoamine	SLC22A3
transporter), member 3
Solute carrier family 25, member 42	SLC25A42
Solute carrier family 44, member 1	SLC44A1
Solute carrier family 45, member 3	SLC45A3
SMAD family member 4	SMAD4
SWI/SNF related, matrix associated, actin dependent	SMARCB1
regulator of chromatin, subfamily b, member 1
SWI/SNF related, matrix associated, actin dependent	SMARCC1
regulator of chromatin, subfamily c, member 1
Sphingomyelin phosphodiesterase, acid-like 3B	SMPDL3B
Small nuclear ribonucleoprotein polypeptide E	SNRPE
Syntrophin, beta 1 (dystrophin-associated protein A1,	SNTB1
59 kDa, basic component 1)
Syntrophin, beta 2 (dystrophin-associated protein A1,	SNTB2
59 kDa, basic component 2)
Syntrophin, gamma 1	SNTG1
Suppressor of cytokine signaling 7	SOCS7
Superoxide dismutase 1, soluble (amyotrophic lateral	SOD1
sclerosis 1 (adult))
Secreted protein, acidic, cysteine-rich (osteonectin)	SPARC
SAM pointed domain containing ets transcription factor	SPDEF
Spleen focus forming virus (SFFV) proviral integration	SPI1
oncogene spi1
Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I,	SPP1
early T-lymphocyte activation 1)
Squalene epoxidase	SQLE
Sulfide quinone reductase-like (yeast)	SQRDL
V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene	SRC
homolog (avian)
Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5	SRD5A2
alpha-steroid delta 4-dehydrogenase alpha 2)
ST3 beta-galactoside alpha-2,3-sialyltransferase 1	ST3GAL1
ST3 beta-galactoside alpha-2,3-sialyltransferase 5	ST3GAL5
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	ST6GAL1
Suppression of tumorigenicity 7	ST7
Signal transducer and activator of transcription 1, 91 kDa	STAT1
Signal transducer and activator of transcription 3 (acute-	STAT3
phase response factor)
Signal transducer and activator of transcription 5B	STAT5B
Six transmembrane epithelial antigen of the prostate 2	STEAP2
Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing	STIP1
protein)
Serine/threonine kinase 11	STK11
Spleen tyrosine kinase	SYK
Synapsin I	SYN1
Synapsin III	SYN3
Tumor-associated calcium signal transducer 1	TACSTD1
TATA box binding protein (TBP)-associated factor, RNA	TAF1C
polymerase I, C, 110 kDa
TAF2 RNA polymerase II, TATA box binding protein	TAF2
(TBP)-associated factor, 150 kDa
T-cell acute lymphocytic leukemia 1	TAL1
Tax1 (human T-cell leukemia virus type I) binding protein 1	TAX1BP1
TATA box binding protein	TBP
Transcription factor 7-like 2 (T-cell specific, HMG-box)	TCF7L2
TEK tyrosine kinase, endothelial (venous malformations,	TEK
multiple cutaneous and mucosal)
Telomerase reverse transcriptase	TERT
Transcription factor AP-2 gamma (activating enhancer	TFAP2C
binding protein 2 gamma)
Transcription factor Dp-1	TFDP1
Transcription factor binding to IGHM enhancer 3	TFE3
Trefoil factor 1	TFF1
TRK-fused gene	TFG
Transferrin receptor (p90, CD71)	TFRC
Transforming growth factor, alpha	TGFA
Transforming growth factor, beta 1	TGFB1
Transforming growth factor, beta 2	TGFB2
Transforming growth factor, beta 3	TGFB3
Transforming growth factor, beta-induced, 68 kDa	TGFBI
Transforming growth factor, beta receptor I (activin A	TGFBR1
receptor type II-like kinase, 53 kDa)
Transforming growth factor, beta receptor II (70/80 kDa)	TGFBR2
Transforming growth factor, beta receptor III	TGFBR3
Transglutaminase 2 (C polypeptide, protein-glutamine-	TGM2
gamma-glutamyltransferase)
Thrombospondin 1	THBS1
Thrombospondin 2	THBS2
Thrombopoietin (myeloproliferative leukemia virus	THPO
oncogene ligand, megakaryocyte growth and development
factor)
T-cell lymphoma invasion and metastasis 1	TIAM1
TIMP metallopeptidase inhibitor 2	TIMP2
Thymidine kinase 1, soluble	TK1
Transmembrane protein with EGF-like and two follistatin-	TMEFF2
like domains 2
Transmembrane protein 134	TMEM134
Transmembrane protein 45B	TMEM45B
Transmembrane protein 65	TMEM65
Transmembrane protein 71	TMEM71
Transmembrane protease, serine 2	TMPRSS2
Tumor necrosis factor receptor superfamily, member 10a	TNFRSF10A
Tumor necrosis factor receptor superfamily, member 10b	TNFRSF10B
Tumor necrosis factor receptor superfamily, member 11a,	TNFRSF11A
NFKB activator
Tumor necrosis factor receptor superfamily, member 11b	TNFRSF11B
(osteoprotegerin)
Tumor necrosis factor receptor superfamily, member 1A	TNFRSF1A
Tumor necrosis factor (ligand) superfamily, member 10	TNFSF10
Tumor necrosis factor (ligand) superfamily, member 8	TNFSF8
Topoisomerase (DNA) I	TOP1
Topoisomerase (DNA) II alpha 170 kDa	TOP2A
Tumor protein p53 (Li-Fraumeni syndrome)	TP53
Tumor protein p53 inducible protein 11	TP53I11
Tumor protein p73	TP73
Translocated promoter region (to activated MET oncogene)	TPR
TPX2, microtubule-associated, homolog (Xenopus laevis)	TPX2
Tripartite motif-containing 38	TRIM38
TRNA methyltransferase 12 homolog (S. cerevisiae)	TRMT12
Transient receptor potential cation channel, subfamily M,	TRPM8
member 8
Trichorhinophalangeal syndrome I	TRPS1
Tuberous sclerosis 1	TSC1
Tuberous sclerosis 2	TSC2
Tetraspanin 13	TSPAN13
Tetraspanin 14	TSPAN14
Tissue specific transplantation antigen P35B	TSTA3
Tetratricopeptide repeat domain 29	TTC29
Thymidylate synthetase	TYMS
TYRO3 protein tyrosine kinase	TYRO3
Ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog,	UBE2J2
yeast)
UBX domain containing 3	UBXD3
Vesicle-associated membrane protein 2 (synaptobrevin 2)	VAMP2
Vav 1 guanine nucleotide exchange factor	VAV1
Vav 2 guanine nucleotide exchange factor	VAV2
Versican	VCAN
Vascular endothelial growth factor A	VEGFA
Vestigial like 3 (Drosophila)	VGLL3
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	WAS
WD repeat domain 67	WDR67
WEE1 homolog (S. pombe)	WEE1
WNT1 inducible signaling pathway protein 1	WISP1
Wingless-type MMTV integration site family, member 10B	WNT10B
Wingless-type MMTV integration site family member 2	WNT2
Wingless-type MMTV integration site family, member 2B	WNT2B
Wingless-type MMTV integration site family, member 5A	WNT5A
Wingless-type MMTV integration site family, member 8B	WNT8B
Werner syndrome	WRN
Wilms tumor 1	WT1
Xanthine dehydrogenase	XDH
Xeroderma pigmentosum, complementation group A	XPA
Xeroderma pigmentosum, complementation group C	XPC
X-ray repair complementing defective repair in Chinese	XRCC1
hamster cells 1
X-ray repair complementing defective repair in Chinese	XRCC4
hamster cells 4
X-ray repair complementing defective repair in Chinese	XRCC5
hamster cells 5 (double-strand-break rejoining; Ku
autoantigen, 80 kDa)
X-ray repair complementing defective repair in Chinese	XRCC6
hamster cells 6 (Ku autoantigen, 70 kDa)
V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	YES1
Yip1 domain family, member 1	YIPF1
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase	YWHAB
activation protein, beta polypeptide
Zinc finger protein 36, C3H type, homolog (mouse)	ZFP36
Zinc finger protein 313	ZNF313
Zinc finger protein 34	ZNF34
Zinc finger protein 511	ZNF511
Zinc finger protein 7	ZNF7

TABLE 7
RNA transcripts used to derive metagene values for 18-RNA
metagene depicted in FIG. 3. The 6-RNA metagene is a subset
of the sequences listed in Table 7, also depicted in FIG. 3.
18-RNA metagene scores were scaled and normalized to
generate ‘POP’ scores depicted in FIG. 4. Weighting
factors were from the linear regression coefficient values;
positive and negative values indicated transcripts correlated
to increased expression in ‘SYS’ and ‘NED’ disease,
respectively with intermediate expression values in the
‘PSA’ disease group.

	SEQ ID No	Weights

	1	−6.08
	2	−5.71
	3	−5.68
	4	−5.39
	5	−5.26
	6	−4.84
	7	−4.7
	8	−4.68
	9	−4.66
	10	−4.55
	11	−4.53
	914	5.32
	915	5.27
	916	4.82
	917	4.64
	918	4.59
	919	4.54
	920	4.49

TABLE 8
RNA transcripts used to derive metagene values for 20-RNA
metagene depicted in FIG. 3. Weighting factors were from the
linear regression coefficient values; positive and negative values
indicated transcripts correlated to increased expression in
‘SYS’ and ‘NED’ disease, respectively with intermediate
expression values in the ‘PSA’ disease group.

	SEQ ID No	Weights

	1	−6.08
	4	−5.39
	6	−4.84
	9	−4.66
	14	−4.37
	15	−4.32
	16	−4.27
	18	−4.2
	19	−4.18
	20	−4.1
	21	−4.09
	915	5.27
	916	4.82
	917	4.64
	920	4.49
	922	4.43
	928	4.27
	929	4.27
	931	4.17
	935	4.08
	936	4.07

TABLE 9
RNA transcripts used to derive 10-RNA metagene values, which
were converted by scaling and normalizing into ‘POP’ scores
depicted in FIG. 5. RNA transcripts were identified using Nearest
Shrunken Centroids algorithm with leave-1-out cross-validation
to distinguish ‘recurren’ (i.e., ‘SYS’) and ‘non-recurrent’
(i.e., ‘PSA’ and ‘NED’) disease from Table 3 RNA transcripts.
Weighting factors were from the test statistic values; positive and
negative values indicated transcripts correlated to increased
expression in ‘recurrent’ and ‘non-recurrent’ disease,
respectively.

	Seq ID	Weights

	3	−5.48
	36	−4.93
	60	−5.72
	63	−4.79
	926	4.61
	971	4.68
	978	5.27
	999	4.74
	1014	4.86
	1022	6.29

TABLE 10
RNA transcripts used to derive 41-RNA metagene values, which
were converted by scaling and normalizing into ‘POP’ scores
depicted in FIG. 6. RNA transcripts were identified using Nearest
Shrunken Centroids algorithm with leave-1-out cross-validation to
distinguish ‘recurrent’ (i.e., ‘SYS’) and ‘non-recurrent’
(i.e., ‘PSA’ and ‘NED’) disease from Table 3 RNA transcripts.
Weighting factors were from the test statistic values; positive and
negative values indicated transcripts correlated to increased
expression in ‘recurrent’ and ‘non-recurrent’ disease,
respectively.

	Seq ID	Weights

	1	−4.1
	2	−4.21
	3	−5.48
	32	−3.87
	33	−3.75
	36	−4.93
	46	−4.14
	60	−5.72
	63	−4.79
	66	−4.02
	69	−3.25
	88	−4.54
	100	−3.63
	241	−4.16
	265	−3.86
	334	−3.36
	437	−4.02
	920	4.36
	925	3.04
	934	3.65
	945	4.03
	947	4.44
	954	4.34
	971	4.68
	978	5.27
	999	4.74
	1004	4.5
	1014	4.86
	1022	6.29
	1023	4.08
	1032	3.49
	1080	3.97
	1093	4.02
	1101	3.55
	1164	3.54
	1248	3.56
	1304	3.14
	1311	3.66
	1330	3.02
	1402	3.45
	1425	3.73

Although the invention has been described with reference to certain specific embodiments, various modifications thereof will be apparent to those skilled in the art without departing from the spirit and scope of the invention. All such modifications as would be apparent to one skilled in the art are intended to be included within the scope of the following claims.