US20190254336A1
2019-08-22
15/901,508
2018-02-21
A liquid composition for electronic cigarettes includes a vaporizable base and one or more sympathomimetic stimulants.
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A24B15/167 » CPC main
Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form; Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
A24B15/16 IPC
Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form; Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
The present invention relates a vaporizable liquid composition for use with smokeless electronic cigarettes (e-cigarettes). More particularly, the invention relates to a vaporizable liquid composition including a vaporizable base and a stimulant.
U.S. Patent Application Publication No. US 2015/0150303 to Jensen discloses an electronic cigarette liquid including a vaporizable base, a flavoring and a non-nicotine stimulant. The non-nicotine stimulants disclosed in US 2015/0150303 are caffeine, guarana and kola nut.
Although US 2015/0150303 discloses the incorporation of certain non-nicotine stimulants in a vaporizable composition for electronic cigarettes, there exists a need for a liquid composition for electronic cigarettes incorporating other types of sympathomimetic stimulants, which have distinctly different chemical structures and effects as compared to known stimulant compositions. Moreover, there exists a need for a liquid composition for electronic cigarettes incorporating various stimulants which may enhance energy, mental focus, alertness, overall cognitive function, and physical performance.
The invention relates to a vaporizable liquid composition for use with smokeless electronic cigarettes (e-cigarettes). More particularly, the invention relates to a vaporizable liquid composition including a vaporizable base and a stimulant.
A stimulant incorporated into a liquid composition for electronic cigarettes according to an aspect of the invention may be 2-Amino-6-methylheptane.
A stimulant incorporated into a liquid composition for electronic cigarettes according to another aspect of the invention may be 2-Amino-5-methylhexane.
A stimulant incorporated into a liquid composition for electronic cigarettes according to another aspect of the invention may be 5-Methyl-2-heptanamine.
A stimulant incorporated into a liquid composition for electronic cigarettes according to another aspect of the invention may be Higenamine.
A stimulant incorporated into a liquid composition for electronic cigarettes according to another aspect of the invention may be 1,3-Dimethylamylamine.
A stimulant incorporated into a liquid composition for electronic cigarettes according to another aspect of the invention may be 1,3-Dimethylbutylamine.
A stimulant incorporated into a liquid composition for electronic cigarettes according to another aspect of the invention may be N,N-Dimethylphenethylamine.
An advantage of a liquid composition for electronic cigarettes according to an aspect of the invention is that the liquid composition may include a sympathomimetic stimulant, which may mimic responses due to stimulation of sympathetic nerves and directly or indirectly activate adrenergic receptors by increasing certain naturally occurring catecholamines such as norepinephrine (noradrenaline), epinephrine (adrenaline) and dopamine levels.
A further advantage of a liquid composition for electronic cigarettes according to an aspect of the invention is that the liquid composition may incorporate a stimulant having the effects of enhancing energy, mental focus, alertness, overall cognitive function, and physical performance.
Other benefits and features of the present invention will become apparent from the following detailed description con-sidered in connection with the accompanying drawings. It is to be understood, however, that the drawings are designed as an illustration only and not as a definition of the limits of the invention.
In the drawings:
FIG. 1 shows a chemical structure for nicotine;
FIG. 2 shows a chemical structure for caffeine;
FIG. 3 shows a chemical structure for 2-Amino-6-methylheptane;
FIG. 4 shows a chemical structure for 2-Amino-5-methylhexane;
FIG. 5 shows a chemical structure for 5-Methyl-2-heptanamine;
FIG. 6 shows a chemical structure for Higenamine;
FIG. 7 shows a chemical structure for 1,3-Dimethylamylamine;
FIG. 8 shows a chemical structure for 1,3-Dimethylbutylamine; and
FIG. 9 shows a chemical structure for N,N-Dimethylphenethylamine.
The invention relates to a vaporizable liquid composition for use with smokeless electronic cigarettes (e-cigarettes). A vaporizable liquid composition according to an aspect of the invention includes a vaporizable base. The vaporizable base may include an organic solvent, such as vegetable glycerin, propylene glycol, polyethylene glycol or a combination of two or more of such ingredients.
The vaporizable liquid composition may optionally include a flavoring. The flavoring may be a natural flavoring or an artificial flavoring or a combination of natural and artificial flavorings.
The vaporizable liquid composition may optionally include nicotine.
The vaporizable liquid composition may further includes one or more stimulants. The stimulant or stimulants may serve as a nicotine alternative, enhance a user's energy and/or enhance a user's cognitive function.
In one aspect of the invention, the stimulant composition may comprise 2-Amino-6-methylheptane. This stimulant composition may also be known by following alternate nomenclatures and/or names: 1,5-Dimethylhexylamine; 6-Methyl-2-heptylamine; 6-methylheptan-2-amine; 6-Methyl-2-heptanamine; Octodrine; Vaporpac and/or 2-aminoisoheptane. Accordingly, reference to the compound 2-Amino-6-methylheptane herein shall be deemed to include each of these compounds as well.
In another aspect of the invention, the stimulant composition may comprise 2-Amino-5-methylhexane. This stimulant composition may also be known by following alternate nomenclatures and/or names: 1,4-Dimethylpentylamine; 1,4-Dimethylamylamine; 5-methyl-2-hexylamine; 2-hexanamine, 5-methyl-; 5-methylhexan-2-amine; and/or pentylamine, 1,4-dimethyl-. Accordingly, reference to the compound 2-Amino-5-methylhexane herein shall be deemed to include each of these compounds as well.
In another aspect of the invention, the stimulant composition may comprise 5-Methyl-2-heptanamine. This stimulant composition may also be known by following alternate nomenclatures and/or names: 5-methylheptan-2-amine; 2-Heptanamine, 5-methyl-; 1,4-Dimethylhexylamine and/or 2-Amino-5-methylheptane. Accordingly, reference to the compound 5-Methyl-2-heptanamine herein shall be deemed to include each of these compounds as well.
In another aspect of the invention, the stimulant composition may comprise Higenamine. This stimulant composition may also be known by following alternate nomenclatures and/or names: Norcoclaurine and/or Demethylcoclaurine. Accordingly, reference to the compound Higenamine herein shall be deemed to include each of these compounds as well.
In another aspect of the invention, the stimulant composition may comprise 1,3-Dimethylamylamine. This stimulant composition may also be known by following alternate nomenclatures and/or names: 1,3-Dimethylpentylamine; 4-methylhexane-2-amine; Methylhexaneamine; 2-Amino-4-methylhexane; Methylhexanamine and/or 1,3-DMAA. Accordingly, reference to the compound 1,3-Dimethylamylamine herein shall be deemed to include each of these compounds as well.
In another aspect of the invention, the stimulant composition may comprise 1,3-Dimethylbutylamine. This stimulant composition may also be known by following alternate nomenclatures and/or names: 4-methylpentan-2-amine; 1,3-Dimethylbutanamine; 2-Amino-4-methylpentane; 4-Methyl-2-aminopentane and/or Amp Citrate. Accordingly, reference to the compound 1,3-Dimethylbutylamine herein shall be deemed to include each of these compounds as well.
In another aspect of the invention, the stimulant composition may comprise N,N-Dimethylphenethylamine. This stimulant composition may also be known by following alternate nomenclatures and/or names: Dimethylphenethylamine; N,N-Dimethylphenylethylamine; N,N-Dimethyl-N-phenethylamine; N,N-Dimethyl-2-phenylethylamine; N-Phenethyldimethylamine; Dimethyl-phenethyl-amine; phenethyldimethylamine and/or Eria Jarensis.
The stimulants indicated above may be used alone in a vaporizable liquid composition for electronic cigarettes, or various combinations of the stimulants may be used. Additionally, a vaporizable liquid composition for electronic cigarettes within the scope of the invention may include nicotine as well as one or more of the stimulants indicated above.
The above-identified stimulants, namely 2-Amino-6-methylheptane, 2-Amino-5-methylhexane, 5-Methyl-2-heptanamine, Higenamine, 1,3-Dimethylamylamine, 1,3-Dimethylbutylamine and N,N-Dimethylphenethylamine are known as sympathomimetic stimulants. This is in contrast to Nicotine, which is a parasympathomimetic stimulant. Moreover, each of these sympathomimetic stimulants have differentiating chemical structures, and are substantially different in terms of chemical structure (as can be seen from the drawings figures provided herein) as well in effect when compared to the stimulant caffeine.
In particular, sympathomimetic stimulants, such as 2-Amino-6-methylheptane, 2-Amino-5-methylhexane, 5-Methyl-2-heptanamine, Higenamine, 1,3-Dimethylamylamine, 1,3-Dimethylbutylamine and N,N-Dimethylphenethylamine, mimic responses due to stimulation of sympathetic nerves. These stimulants are able to directly or indirectly activate adrenergic receptors by increasing certain naturally occurring catecholamines, such as norepinephrine (noradrenaline), epinephrine (adrenaline) and dopamine levels.
Dopamine functions as a neurotransmitter in the brain. Increasing dopamine levels may be beneficial as dopamine plays a vital role in bodily motor control, executive functions like mental processes and skills, motivation, mood, arousal and reward. Low dopamine levels can lead to fatigue, addictive behavior, mood swings, memory loss and a lack of motivation.
Epinephrine (adrenaline) is released by the adrenal glands. Its release into the blood stream increases heart rate and blood flow, resulting in more oxygen and blood flow to muscles, creating an instant source of energy and allowing body to react quickly. The natural secretion of epinephrine is often a result of exercise. Epinephrine has also been shown to play an important role in long term memory function in humans.
Norepinephrine (noradrenaline), which is also released by the adrenal glands, functions as both a hormone and neurotransmitter in the body. The general function of norepinephrine believed to involve mobilizing the brain and body for action. In the brain, norepinephrine increases arousal and alertness, enhances mental cognition and attention, promotes vigilance, and enhances retrieval and formation of memory.
For these reasons, sympathomimetic stimulants, such as Amino-6-methylheptane, 2-Amino-5-methylhexane, 5-Methyl-2-heptanamine, Higenamine, 1,3-Dimethylamylamine, 1,3-Dimethylbutylamine and N,N-Dimethylphenethylamine, when incorporated into a vaporizable liquid composition to be used with an electronic cigarette for inhalation and absorption by a user of the electronic cigarette may enhance a user's energy, mental focus, alertness, overall cognitive function, and physical performance.
A liquid composition according to an aspect of the invention may be provided, for example in a 30 ml, 60 ml or 100 ml bottle. In terms of dosing, a 30 ml bottle of the vaporizable liquid composition may generally contain no less than 0.001 mg and no more than 100 g of the stimulant composition, for example no less than 1 mg and no more than 2 g of the stimulant composition.
While a number of embodiments of the present invention have been shown and described, it is obvious that many changes and modifications may be made thereunto without departing from the spirit and scope of the invention.
1. A liquid composition for electronic cigarettes comprising:
a vaporizable base; and
2-Amino-6-methylheptane.
2. A liquid composition for electronic cigarettes comprising:
a vaporizable base; and
2-Amino-5-methylhexane.
3. A liquid composition for electronic cigarettes comprising:
a vaporizable base; and
5-Methyl-2-heptanamine.
4. A liquid composition for electronic cigarettes comprising:
a vaporizable base; and
Higenamine.
5. A liquid composition for electronic cigarettes comprising:
a vaporizable base; and
1,3-Dimethylamylamine.
6. A liquid composition for electronic cigarettes comprising:
a vaporizable base; and
1,3-Dimethylbutylamine.
7. A liquid composition for electronic cigarettes comprising:
a vaporizable base; and
N,N-Dimethylphenethylamine.