IDENTIFICATION AND ISOLATION OF HUMAN CORNEAL ENDOTHELIAL CELLS (HCECS)

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuations of U.S. patent application Ser. No. 14/888,875, filed Nov. 3, 2015 (published as US20160102290), which is the U.S. National Stage of International Patent Application No. PCT/US2014/036616, filed May 2, 2014, which claims the benefit of U.S. Patent Application No. 61/819,146, entitled “METHOD FOR IDENTIFYING AND ISOLATING HUMAN CORNEAL ENDOTHELIAL CELLS (HCECS),” filed May 3, 2013, the contents of each of which are hereby incorporated by reference in their entireties.

INCORPORATION-BY-REFERENCE OF MATERIAL ELECTRONICALLY FILED

Incorporated by reference in its entirety herein is a computer-readable nucleotide/amino acid sequence listing submitted concurrently herewith and identified as follows: One 821,867 byte ASCII (text) file named “Seq_List” created on Aug. 13, 2018.

BACKGROUND OF THE INVENTION

When the innermost layer of the cornea, the endothelium, is damaged, for example from trauma (e.g., from cataract surgery), disease or dystrophy, the cornea swells with fluid (edema) and loses its optical clarity. Patients consequently suffer from vision loss and pain, and their only option to treat advanced disease is with corneal transplant surgery (also known as penetrating keratoplasty, PK) or Descemet's stripping endothelial keratoplasty (DSAEK), both technically difficult procedures that are very invasive to the patient and have significant limitations, such as the number of donor corneas available.

Recent studies have proposed the use of human corneal endothelial cells (HCECs) obtained from cadaveric donors to replace the damaged cells. See, e.g., Joyce and Zhu, Cornea. 2004 November; 23(8 Suppl):S8-S19; Engelmann, et al., Exper. Eye Res., vol. 78, no. 3, pp. 573-578, 2004. A potential advantage to such an approach could be the expansion of HCECs ex vivo before implantation into patients, thereby overcoming the limited tissue availability. HCECs can be expanded in defined tissue culture media for at least 5 passages, greatly expanding the number of cells derived from a single donor.

One of the main problems with such a technique is that the lack of defined surface markers specific for HCECs makes it difficult to confirm the identity of HCECs after several passages, or to select HCECs away from contaminating cells, or to identify the subset of HCECs that are likely to have the highest clinical efficacy from among the full population of HCECs, as current identification criteria are limited to cell morphology and the expression of functional genes, such as ATP1A1 (see, e.g., Kaye and Tice, Invest Ophthalmol 1966; 522-32; Leuenberger and Novikoff, J Cell Biol. 1974; 60721-731; McCartney et al., Curr Eye Res, 1987; 61479-1486) or the tight junction marker zonula occludens-1(ZO-1) (see, e.g., Petroll et al., Curr Eye Res. 1999 January; 18(1):10-9), neither of which are specific to HCECs. It is also difficult to isolate HCECs from contaminant fibroblasts in culture, from neighboring cells in whole corneas, or from residual corneas from DSAEK.

In this regard, the current isolation method for obtaining HCECs from intact corneas comprises a peel-off step, where the endothelium and its basement membrane (Descemet's membrane) are peeled off the stroma and collected. See, e.g., Ko-Hua Chen et al., “Transplantation of Adult Human Corneal Endothelium Ex Vivo: A Morphologic Study,” Cornea 20(7): 731-737, 2001. The tissue collected thus contains HCECs, but it may also contain corneal keratocytes (specialized fibroblasts residing the stroma). Corneal keratocytes (also referred to herein simply as “keratocytes”) are undesirable contaminants in the HCECs culture, as they grow faster than the latter cells and they can take over the culture dish, thus making the final product essentially useless. In addition to residual stromal tissue, keratocytes may also arise from human endothelial cells which transform spontaneously into other types of cells such as keratocytes (see, e.g., G S. L. Peh et al., “Optimization of Human Corneal Endothelial Cells for Culture: The Removal of Corneal Stromal Fibroblast Contamination Using Magnetic Cell Separation,” International Journal of Biomaterials, Volume 2012 (2012), Article ID 601302, 8 pages.)

SUMMARY OF THE INVENTION

Some aspects of the invention are directed to methods for the identification, enrichment and/or isolation of human corneal endothelial cells (HCECs).

In some embodiments, the method comprises a positive selection process in which a cell population containing human corneal cells is contacted with a positive affinity reagent that selectively binds to HCECs relative to cells other than HCECs. The cells to which the positive affinity reagent is bound are then selected, with the result being that selected cells are enriched with HCECs. In some embodiments, two or more differing positive affinity reagents which bind to HCECs but which do not bind to cells other than HCECs are employed.

As defined herein “cells other than human corneal endothelial cells” (or “cells other than HCECs”) include corneal keratocytes as well as HCECs of lower utility (e.g., HCECs that have undergone fibroblastic or mesenchymal transformation, etc.).

In other embodiments, the method comprises a negative selection process in which a cell population containing human corneal cells is contacted with a negative affinity reagent that selectively binds to cells other than HCECs (e.g., corneal keratocytes, etc.) relative to HCECs. The cells to which the negative affinity reagent is bound are then removed, with the result being that the cells that are not removed are enriched with HCECs. In some embodiments, two or more differing negative affinity reagents which bind to cells other than HCECs (e.g., corneal keratocytes, etc.) but which do not bind to HCECs are employed.

In some embodiments, the method comprises both (a) positive selection using one or more affinity reagents agents and (b) negative selection using one or more negative affinity reagents.

Other aspects of the invention are directed to affinity reagents and kits useful for the identification, enrichment and/or isolation of HCECs.

Still other aspects of the invention are direct to isolated and/or enriched cell populations that contain HCECs. In some embodiments, such enriched cell populations may contain affinity reagents for the purification of HCECs.

Further aspects of the invention a set forth in the following paragraphs:

• • Aspect 1. A method of forming a composition enriched with human corneal endothelial cells comprising: (a) contacting a cell population containing human corneal cells with a first positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells and (b) selecting cells to which the first positive affinity reagent is bound.
  • Aspect 2. The method of aspect 1, wherein the first positive affinity reagent selectively binds to human corneal endothelial cells relative to corneal keratocytes, human corneal endothelial cells of lower utility, or both.
  • Aspect 3. The method of aspect 1, wherein the first positive affinity reagent selectively binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (1) through SEQ ID NO (58) of Table 2.
  • Aspect 4. The method of aspect 1, wherein the first positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2.
  • Aspect 5. The method of aspect 1, wherein the first positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57).
  • Aspect 6. The method of any of aspects 1-5, wherein the first positive affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix.
  • Aspect 7. The method of any of aspects 1-6, wherein the first positive affinity reagent comprises an antibody or aptamer that is coupled to a label.
  • Aspect 8. The method of aspect 7, wherein the label is selected from a magnetic label, a hapten (e.g., biotin) and a fluorescent label.
  • Aspect 9. The method of any of aspects 1-8, further comprising (a) contacting said cell population containing human corneal cells with a second positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells and (b) selecting cells to which the second positive affinity reagent is bound, wherein the second positive affinity reagent differs from the first positive affinity reagent.
  • Aspect 10. The method of aspect 9, wherein the second positive affinity reagent selectively binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (1) through SEQ ID NO (58) of Table 2.
  • Aspect 11. The method of aspect 9, wherein the second positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2.
  • Aspect 12. The method of aspect 9, wherein the second positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57).
  • Aspect 13. The method of any of aspects 9-12, wherein the second positive affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix or a label.
  • Aspect 14. The method of any of aspects 1-13, further comprising (a) contacting said cell population containing human corneal cells with a first negative affinity reagent that selectively binds to cells other than human corneal endothelial cells relative to human corneal endothelial cells and (b) removing the cells to which the first negative affinity reagent is bound.
  • Aspect 15. The method of aspect 14, wherein the first negative affinity reagent selectively binds to corneal keratocytes, human corneal endothelial cells of lower utility, or both, relative to human corneal endothelial cells.
  • Aspect 16. The method of aspect 14, wherein the first negative affinity reagent selectively binds to a corneal protein selected from protein products of genes Y1 through Y23 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes Y1 through Y23 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (59) through SEQ ID NO (96) of Table 2, or wherein the first negative affinity reagent selectively binds to a corneal protein selected from protein products of genes Z1 through Z8 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes Z1 through Z8 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (97) through SEQ ID NO (109) of Table 2.
  • Aspect 17. The method of aspect 14, wherein the first negative affinity reagent comprises an antibody or aptamer that binds to a protein product of gene Y6 of Table 2.
  • Aspect 18. The method of aspect 14, wherein the first negative affinity reagent comprises an antibody or aptamer that binds to one or more of SEQ ID NO (66), SEQ ID NO (67) or SEQ ID NO (68).
  • Aspect 19. The method of any of aspects 14-18, wherein the first negative affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix or a label.
  • Aspect 20. A composition enriched with human corneal endothelial cells that is made by the method of any of aspects 1-19.
  • Aspect 21. A kit comprising (a) a positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells and (b) a negative affinity reagent that selectively binds to cells other than human corneal endothelial cells relative to human corneal endothelial cells.
  • Aspect 22. The kit of aspect 21, wherein the positive affinity reagent selectively binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (1) through SEQ ID NO (58) of Table 2.
  • Aspect 23. The kit of aspect 21, wherein the first positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2.
  • Aspect 24. The kit of aspect 21, wherein the first positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57).
  • Aspect 25. The kit of any of aspects 21-24, wherein the positive affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix or a label.
  • Aspect 26. The kit of any of aspects 21-25, wherein the negative affinity reagent selectively binds to a corneal protein selected from protein products of genes Y1 through Y23 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes Y1 through Y23 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (59) through SEQ ID NO (96) of Table 2, or wherein the negative affinity reagent selectively binds to a corneal protein selected from protein products of genes Z1 through Z8 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes Z1 through Z8 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (97) through SEQ ID NO (109) of Table 2.
  • Aspect 27. The kit of any of aspects 21-25, wherein the negative affinity reagent comprises an antibody or aptamer that binds to a protein product of gene Y6 of Table 2.
  • Aspect 28. The kit of any of aspects 21-25, wherein the first negative affinity reagent comprises an antibody or aptamer that binds to one or more of SEQ ID NO (66), SEQ ID NO (67) or SEQ ID NO (68).
  • Aspect 29. The kit of any of aspects 21-28, wherein the negative affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix or a label.
  • Aspect 30. An affinity reagent selected from (a) a solid matrix or a label coupled to an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (1) through SEQ ID NO (58) of Table 2, and (b) a solid matrix or a label coupled to an antibody or aptamer that binds to a corneal protein selected from protein products of genes Y1 through Y23 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (59) through SEQ ID NO (96) of Table 2, and protein products of genes Z1 through Z8 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (97) through SEQ ID NO (109) of Table 2.
  • Aspect 31. A composition enriched with human corneal endothelial cells comprising: (a) human corneal cells and (b) a first positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells.
  • Aspect 32. The composition of aspect 31, comprising human corneal endothelial cells to which the first positive affinity reagent is bound.
  • Aspect 33. The composition of any of aspects 31-32, wherein the first positive affinity reagent selectively binds to human corneal endothelial cells relative to corneal keratocytes, human corneal endothelial cells of lower utility, or both.
  • Aspect 34. The composition of any of aspects 31-33, wherein the first positive affinity reagent selectively binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (1) through SEQ ID NO (58) of Table 2.
  • Aspect 35. The composition of any of aspects 31-33, wherein the first positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2.
  • Aspect 36. The composition of any of aspects 31-33, wherein the first positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57).
  • Aspect 37. The composition of any of aspects 31-36, wherein the first positive affinity reagent comprises an antibody or aptamer that is coupled to a label.
  • Aspect 38. The composition of aspect 37, wherein the label is selected from a magnetic label, a hapten (e.g., biotin) and a fluorescent label.
  • Aspect 39. The composition of any of aspects 31-38, further comprising a second positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells, wherein the second positive affinity reagent differs from the first positive affinity reagent.
  • Aspect 40. The composition of aspect 39, comprising human corneal endothelial cells to which the second positive affinity reagent is bound.
  • Aspect 41. The composition of any of aspects 39-40, wherein the second positive affinity reagent selectively binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (1) through SEQ ID NO (58) of Table 2.
  • Aspect 42. The composition of any of aspects 39-40, wherein the second positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2.
  • Aspect 43. The composition of any of aspects 39-40, wherein the second positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57).
  • Aspect 44. The composition of any of aspects 39-43, wherein the second positive affinity reagent comprises a label.
  • Aspect 45. The composition of any of aspects 31-44, comprising a measurable amount of one or more negative affinity reagents that selectively binds to cells other than human corneal endothelial cells relative to human corneal endothelial cells.
  • Aspect 46. The composition of aspect 45, wherein the one or more negative affinity reagents selectively binds to corneal keratocytes, human corneal endothelial cells of lower utility, or both, relative to human corneal endothelial cells.
  • Aspect 47. The composition of any of aspects 45-46, wherein the one or more negative affinity reagents selectively bind to a corneal protein selected from protein products of genes Y1 through Y23 of Table 2, and may comprise, for example, one or more antibodies that bind to one or more corneal proteins selected from protein products of genes Y1 through Y23 of Table 2, including one or more antibodies or aptamers that bind to one or more proteins selected from SEQ ID NO (59) through SEQ ID NO (96) of Table 2, or the one or more negative affinity reagents selectively bind to a corneal protein selected from protein products of genes Z1 through Z8 of Table 2, and may comprise, for example, one or more antibodies or aptamers that bind to one or more corneal proteins selected from protein products of genes Z1 through Z8 of Table 2, including one or more antibodies or aptamers that bind to one or more proteins selected from SEQ ID NO (97) through SEQ ID NO (109) of Table 2.
  • Aspect 48. The composition of any of aspects 45-46, wherein the one or more negative affinity reagents comprise an antibody or aptamer that binds to a protein product of gene Y6 of Table 2.
  • Aspect 49. The composition of any of aspects 45-46, wherein the one or more negative affinity reagents comprise an antibody or aptamer that binds to one or more of SEQ ID NO (66), SEQ ID NO (67) or SEQ ID NO (68).
  • Aspect 50. The composition of any of aspects 45-49, wherein the one or more negative affinity reagents comprise an antibody or aptamer that is coupled to a label.

These and various other aspects and embodiments and as well as various advantages of the present invention will become immediately apparent to those of ordinary skill in the art upon review of the Detailed Description and appended claims to follow.

BRIEF DESCRIPTION OF THE DRAWINGS

FIGS. 1A-1C are bright field micrographs of HCECs and keratocytes in culture, with FIG. 1A illustrating a HCEC culture having preserved a typical cobblestone morphology (P2-HCEC-Good), FIG. 1B illustrating a HCEC culture having become fibroblastic (P3-HCEC-Fibroblastic), and FIG. 1C illustrating a human corneal keratocyte culture (P2-HCEC-Keratocytes).

FIG. 2 illustrates in bar graph form expression of four surface markers in different corneal cell populations analyzed by flow cytometry.

FIGS. 3A-3C are dual-color fluorescence histograms of HCECs and keratocytes. These dot plots show the differential expression of two surface markers (CD56:CD166, CD56:CD90 and CD56:CAR) in each cell population, with FIG. 3A corresponding to the P2-HCEC-Good culture shown in FIG. 1A, FIG. 3B corresponding to the P3-HCEC-Fibroblastic culture shown in FIG. 1B, and FIG. 3C corresponding to the P2-HCEC-Keratocytes culture shown in FIG. 1C.

FIGS. 4A-4D present Fluorescence profiles illustrating expression of four surface markers, specifically, CD56 (FIG. 4A), CAR (FIG. 4B), CD109 (FIG. 4C) and CD248 (FIG. 4D) in three different HCEC populations, specifically, canonical (good) HCECs, mixed (canonical and fibroblastic) HCECs, and fibroblastic (HCECs), analyzed by flow cytometry.

FIG. 5 illustrates in bar graph form expression of four surface markers in three different HCEC populations analyzed by flow cytometry.

FIGS. 6A-6C illustrates dual-color fluorescence histograms for various pairs of surface markers, specifically, CD56:CD248 (FIG. 6A), CD56:CD109 (FIG. 6B) and CD56:CAR (FIG. 6C) in three different HCEC populations, specifically, canonical HCECs, mixed HCECs and fibroblastic HCECs.

FIG. 7 illustrates trans-endothelial electrical resistance (TEER) as a function of time for cell cultures of three different HCEC populations.

DETAILED DESCRIPTION

A more complete understanding of the present invention is available by reference to the following detailed description of numerous aspects and embodiments of the invention. The detailed description of the invention which follows is intended to illustrate but not limit the invention.

As noted above, in some aspects, the present disclosure pertains to positive selection processes in which cell populations containing human corneal cells are contacted with one or more positive affinity reagents that selectively bind to HCECs relative to cells other than HCECs (e.g., corneal keratocytes, etc.), including positive affinity reagents that selectively bind to HCECs that are likely to have a higher clinical efficacy relative to the general HCEC population

In other aspects, the present disclosure pertains to negative selection processes in which cell populations containing human corneal cells are contacted with one or more negative affinity reagents that bind selectively bind to cells other than HCECs (e.g., corneal keratocytes, etc.) relative to HCECs.

These negative and positive selection methods may be used independently or in combination with one another, for example, to identifying HCECs, to isolate HCECs and/or to enrich cell populations with HCECs, among other uses.

Cell populations suitable for HCEC enrichment or isolation include those obtained from intact or residual human corneas, which may come, for instance, from embryonic, fetal, pediatric or adult tissue. For example, intact corneas may be subjected to a peel-off step in which the endothelium and its basement membrane (Descemet's membrane) are peeled off the stroma and collected. See Ko-Hua Chen et al., “Transplantation of Adult Human Corneal Endothelium Ex Vivo: A Morphologic Study,” Cornea 20(7): 731-737, 2001. In other embodiments, cell populations may be obtained from residual corneas (e.g., eye tissue remaining after a corneal button has been used for DSAEK).

Tissue from intact and residual corneas may be separated into individual cells by processes such as enzymatic and/or mechanical dissociation. At this step, cells are incubated for a period of time at room temperature or at 37° C. with a single enzyme or a combination of enzymes including some of the following: collagenase, papain, dispase, elastase, trypsin/EDTA, and/or DNAse. Later the tissues are mechanically dissociated using a conventional pipette or a glass pipette to obtain individual cells or cell clumps than can be then expanded in culture. See, e.g., Li W. et al., Invest Ophthalmol Vis Sci 2007; 48: 614; Ishino Y. et al., Invest Ophthalmol Vis Sci 2004; 45: 800; Chen K. H. et al., Cornea 2001; 20: 731.

The medium in which the cells may be suspended will be any medium which maintains the viability of HCECs. Various media are commercially available and may be used including Minimal Essential Medium (MEM), Dulbecco's Modified Eagle Medium (DMEM), Opti-MEMO, Media 199 or M199, Dulbecco's Modified Eagle Medium with Nutrient Mixture F-12 (DMEM/F-12), F99 Ham's F12, SHEM Ham's F12, EGM-2 endothelial growth medium frequently supplemented with serum of human or animal origin, BSA, HSA, growth factors, antioxidants, antibiotics, antimicotic agents, hormones, amino acids, and peptides. Specific examples of media are shown in Table 1 to follow.

TABLE 1
Base Medium	Serum	Growth Factors & Supplements
[M1]	10%	2 ng/ml bFGF
DMEM		50 U/ml penicillin
		50 μg/ml streptomycin
[M2]	8%	20 ng/ml NGF
Opti-MEM-I		5 ng/ml EGF
		20 μg/ml ascorbic acid
		200 mg/L calcium chloride
		100 μg/ml pituitary extract
		50 μg/ml gentamicin
		1x antibiotic/antimycotic
		0.08% chondroitin sulphate
[M3]	5%	0.5% DMSO
SHEM		2 ng/ml EGF
Ham's F12 & DMEM		5 μg/ml insulin
(1:1 ratio)		5 μg/ml transferrin
		5 ng/ml selenium
		0.5 μg/ml hydrocortisone
		1 nM cholera toxin
		50 μg/ml gentamicin
		1.25 μg/ml amphotericin B
[M4]	5%	20 μg/ml ascorbic acid
F99		20 μg/ml bovine insulin
Ham's F 12 & M100		2.5 μg/mol transferrin
(1:1 ratio)		0.6 ng/ml sodium selentite
		10 ng/ml bFGF

Cell cultures from intact and residual corneas contain unwanted contaminant cells which arise from residual non-endothelial tissue (e.g., stroma, epithelium, etc.) that may be present in the sample. In a culture of HCECs, HCECs that are of low cell transplant utility compared to other HCECs of high cell transplant utility may also be considered, in some fashion, “contaminants”.

Cell populations suitable for HCEC enrichment or isolation also include HCEC cultures in which contaminant cells have out-multiplied HCECs or in which HCECs have transformed spontaneously into other types of cells (e.g., keratocytes, etc.). As previously noted, contaminant cells such as keratocytes are particularly undesirable where it is desired to expand an HCEC culture ex vivo, because such cells grow faster than HCECs and can thus take over a cell culture.

Consequently, various aspects of the invention pertain to methods, reagents and kits for separation of HCECs from other cells, particularly, keratocytes and/or HCECs of lower utility. The HCECs are separated from mixtures of cells by techniques that select cells having particular characteristics.

Human corneal endothelial cells may identified or selected (a) through positive cell markers, which are cell markers that are found on the surfaces of HCECs but which are not found on the surfaces of contaminant cells which may be intermixed with HCECs (e.g., positive selection), (b) through negative cell markers, which are cell markers that are found on surfaces of contaminant cells that are intermixed with HCECs and but which are not found on the surfaces of HCECs (e.g., negative selection), and through a combination of positive and negative cell markers.

For example, in the case where whole human corneas are used as a source of endothelial cells, positive cell markers may be selected from corneal proteins which are found in the endothelium (which is formed from HCECs) but which are not found in other corneal tissue (i.e., the stroma and/or the epithelium). Conversely, negative cell markers may be selected from corneal proteins which are found in corneal tissue other than endothelium tissue (i.e., the stroma and/or the epithelium) but which are not found in corneal endothelium.

As another example, in the case where the source of endothelial cells is an endothelium and basement membrane that have been separated from the stroma and epithelium of an intact cornea, positive cell markers may be selected from corneal cell proteins which are found in the endothelium but which are not found in the stroma, while negative cell markers may be selected from corneal cell proteins which are found in the stroma but which are not found in corneal endothelium.

Corneal proteins which may be useful as cell markers in conjunction with the present invention include the suitable proteins selected from those presented in the Table 2 set forth in Appendix A.

Positive cell markers include suitable corneal proteins selected from protein products of genes X1-X26 in Table 2 (e.g., SEQ ID NO (1) through SEQ ID NO (58)) which are present in the corneal endothelium but are not present in the stroma or the epithelium.

Negative cell markers include (a) suitable corneal proteins selected from protein products of genes Y1-Y23 in Table 2 (e.g., SEQ ID NO (59) through SEQ ID NO (96)), which are present in the stroma and in epithelium but are not present in the endothelium and (b) suitable corneal proteins selected from protein products of genes Z1-Z8 in Table 2 (e.g., SEQ ID NO (97) through SEQ ID NO (109)), which are present in the stroma but are not present in the corneal endothelium (or epithelium).

As previously noted, in some aspects, the present disclosure pertains to (a) positive selection processes in which cell populations containing human corneal cells are contacted with one, two, three, four or more positive affinity reagents that selectively bind to HCECs relative to cells other than HCECs (e.g., corneal keratocytes, etc.), (b) negative selection processes in which cell populations containing human corneal cells are contacted with one, two, three, four or more negative affinity reagents that selectively bind to cells other than HCECs (e.g., corneal keratocytes, etc.) relative to HCECs, and (c) combinations of (a) and (b).

For this purpose, affinity reagents are employed which preferentially bind to various corneal proteins. Positive affinity reagents are those that preferentially bind to positive cell markers associated with HCECs while negative affinity reagents are those that preferably bind to negative cell markers associated with contaminant cells other than HCECs.

Various positive cell markers are described above and include corneal proteins which are found in the endothelium (which is formed from HCECs) but which are not found in other corneal tissue (i.e., the stroma and/or the epithelium). Various negative cell markers are also described above and include corneal proteins which are found in corneal tissue other than endothelium (i.e., the stroma and/or the epithelium) but which are not found in corneal endothelium.

Those skilled in the art will recognize that suitable negative and positive affinity reagents can be employed in any order and/or in any combination.

Affinity reagents suitable for use in the present disclosure may comprise any species which selectively binds to a given surface marker, including positive affinity reagents which selectively bind to positive cell markers and negative affinity reagents which selectively bind to negative cell markers.

Especially useful affinity reagents for the practice of the invention are antibodies (also referred to herein as “affinity antibodies”), nucleic acid aptamers and other engineered forms of protein scaffolds. Antibodies include whole antibodies and antibody fragments, e.g. Fab, F(ab′)2, light or heavy chain fragments, etc.

Affinity antibodies selected for use will have a low level of non-specific interactions.

Affinity antibodies may be polyclonal or monoclonal and, where not commercially available, may be readily produced by techniques known to those skilled in the art.

For instance, affinity antibodies to a given corneal protein may be obtained by immunizing a xenogeneic immunocompetent mammalian host (including murine, rodentia, lagomorpha, ovine, porcine, bovine, etc.) with the corneal protein of interest. Immunizations are performed in accordance with conventional techniques, where the corneal proteins may be injected subcutaneously, intramuscularly, intraperitoneally, intravascularly, etc., over a course of one or more injections. After completion of the immunization schedule, the antiserum may be harvested in accordance with conventional methods to provide polygonal antisera specific for the corneal protein of interest. Lymphocytes may also be harvested from the appropriate lymphoid tissue, e.g. spleen, draining lymph node, etc., and fused with an appropriate fusion partner, for example, a myeloma line, producing a hybridoma secreting a specific monoclonal antibody. Screening clones of hybridomas for the antigenic specificity of interest is performed in accordance with conventional methods.

In numerous embodiments, affinity antibodies are coupled to a suitable substrate, for example, a label or a solid matrix. Labels include magnetic labels such as magnetic beads or micro or nanoparticles including superparamagnetic nanoparticles, which allow for ease of separation. Labels also include biotin, which binds with high affinity to avidin or streptavidin. Labels further include fluorochromes, which can be used with flow cytometry, e.g., fluorescence activated cell sorting (FACS), or the like, to allow for ease of separation of a particular cell type. Fluorescence activated cell sorters have varying degrees of sophistication, such as multiple color channels, low angle and obtuse light scattering detecting channels, impedance channels, etc. Fluorochromes include phycobiliproteins, e.g., phycoerythrin and allophycocyanins, fluorescein and Texas red, cy7 and cy5, among others. Multiple antibodies each with an affinity to a particular corneal protein may each be labeled with a different fluorochrome, to permit independent sorting (multi-color analyses) for each associated cell protein.

Cell selection may also be achieved by “panning” with an affinity antibody attached to a solid matrix, e.g. a plate, an immobilized bead, and so forth. For example, an affinity antibody that has specificity for a particular corneal protein may be bound to a solid matrix and corneal cells displaying that particular corneal protein can be captured by the immobilized antibody while the other cells remain in suspension and can be removed.

Any sorting technique may be employed which is not unduly detrimental to the viability of the selected cells. Combinations of the above techniques may be used.

The precise method for coupling an antibody to a given substrate (e.g., a label, solid matrix, etc.) is not critical to the practice of the present disclosure, and a number of alternatives are known in the art. For example, affinity antibodies may directly or indirectly be coupled to a substrate. Direct coupling to a substrate can be achieved by use of various chemical linking groups, as known in the art. For example, an antibody can be coupled to a substrate through side chain amino or sulfhydryl groups and heterofunctional cross-linking reagents. Many heterofunctional compounds are available for linking to various entities. Specific examples include 3-(2-pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) or 4-(N-maleimidomethyl)-cyclohexane-1-carboxylic acid N-hydroxysuccinimide ester (SMCC), which can react with a reactive sulfhydryl group on the antibody and a reactive amino group on the substrate.

Alternatively, affinity antibodies can be indirectly coupled to a substrate via a hapten or a secondary antibody. For instance, the antibody may be directly conjugated to a hapten, and hapten-specific binding species may be conjugated to the substrate. Suitable haptens include digoxin, digoxigenin, FITC, dinitrophenyl, nitrophenyl, avidin, streptavidin, biotin, etc. For example, an antibody may be coupled to one member of a high affinity binding system (e.g., biotin) and another member of the high affinity binding system (e.g., avidin) attached to a substrate. Methods for conjugation of a hapten to a protein are known in the art, and kits for such conjugations are commercially available. The secondary antibody may be directly or indirectly bound to the substrate.

During cell separation, coupled antibodies may be combined with a suspension of cells and incubated for a period of time sufficient for the antibodies to bind to proteins on the cells. The amount of antibody necessary to bind a particular cell subset may be empirically determined by performing a test separation and analysis. The cells and antibodies are incubated for a period of time sufficient for binding to occur.

The medium in which the cells are separated will be any medium which maintains the viability of the cells. Various media are commercially available and include those listed above.

Coupled affinity antibodies include coupled positive affinity antibodies specific for the corneal proteins which are present on human corneal endothelial cells and which are not present on contaminant cells such as stromal and/or epithelial cells (for positive selection) and coupled negative affinity antibodies specific for corneal proteins which are present on contaminant cells such as stromal and/or epithelial cells and which are not present on human corneal endothelial cells (negative selection).

Once the antibody is bound to the cell, the bound cells are separated in accordance with the specific antibody preparation. For example, FACS separation may be used with fluorochrome labeled antibodies, immunomagnetic selection may be used with magnetic-labeled antibodies, “panning” may be employed with immobilized antibodies, and so forth.

Cells may be separated from affinity antibodies using known techniques, as desired. As a specific example, where an antibody in an immunopanning process is a positive selection antibody, the matrix with attached endothelial cells may be washed to remove unbound cells and the endothelial cells released using a suitable technique (e.g., trypsin digest).

While various specific embodiments employing antibodies as affinity reagents are specifically described herein, it is to be understood that other affinity reagents for binding positive or negative cell markers can be used in the same fashion, including nucleic acid aptamers and other engineered forms of protein scaffolds. Aptamers are synthetic oligonucleotides selected from pools of random-sequence oligonucleotides which bind to a wide range of biomolecular targets with high affinity and specificity. See, e.g., J. Wang and G. Li, “Aptamers against cell surface receptors: selection, modification and application,” Curr Med Chem. 2011; 18(27):4107-16.

The separated cells may be collected in any appropriate medium that maintains the viability of the cells.

Cell populations enriched with HCECs may thus be achieved in this manner. The HCEC population may constitute 50% or more of the cells in the cell composition, preferably at 75% or more of the cells in the cell composition, more preferably at 90% or more of the cells in the cell composition, and may be as many as 95% or more (e.g. substantially pure) of the cells in the cell population. Conversely, the cell populations may contain up to 50% of cells other than HCECs (e.g., corneal keratocytes, etc.), for instance 50% or less of such cells, preferably 25% or less of such cells, more preferably 10% or less of such cells, and may be as few as 5% or less of such cells.

The enriched cell population may be used immediately or stored. For example, at room temperature, at 4° C., at 37° C. or the cells may be frozen at liquid nitrogen temperatures and stored for long periods of time.

In certain embodiments, the enriched cells may be further expanded in vitro by adding culture media as described widely in the literature. See, e.g., Li W et al., Invest Ophthalmol Vis Sci 2007; 48: 614.; Ishino Y et al., Invest Ophthalmol Vis Sci 2004; 45: 800; Chen K H et al., Cornea 2001; 20: 731.

The enriched HCEC compositions thus obtained have a variety of uses in clinical therapy, research, development, and commercial purposes.

For example, for therapeutic purposes, human corneal endothelial cells may be ocularly administered to an eye of a patient in order to treat corneal endothelial cell loss or dysfunction.

Other aspects of the invention pertain to kits for conducting cell separations as described herein. Such kits may include any combination of the following, among other elements: (a) one, two, three or more positive affinity reagents, each of which may be, for example, in the form of a positive affinity antibody attached to a suitable substrate such as a solid matrix (e.g. a plate, immobilized bead, etc.) or label (e.g., magnetic label, fluorescent label, etc.), (b) one, two, three or more unlabeled positive affinity antibodies, which the end user could label using standard methods, choosing their preferred labels (e.g., fluorophores, haptens, etc.), (c) one, two, three or more negative affinity reagents, each of which may be, for example, in the form of a negative affinity antibody attached to a suitable substrate such as a solid matrix (e.g. a plate, immobilized bead, etc.) or label (e.g., magnetic label, fluorescent label, etc.), (d) or one, two, three or more unlabeled negative affinity antibodies, which the end user could label using standard methods, choosing their preferred labels (e.g., fluorophores, haptens, etc.); (e) a combination of (a) and (c); (f) a combination of (b) and (d); (g) packaging; (h) printed materials with one or more of the following: (i) storage information and (ii) instructions regarding how to use the materials contained in the kit (e.g., positive affinity reagents, negative affinity reagents, a combination of antibodies for sequential use, etc.).

Example 1

HCECs were isolated from cadaveric donor corneas (Tampa Lions Eye Bank) and cultured and expanded following the method described by Joyce and Zhu in Cornea. 2004 November; 23(8 Suppl):S8-S19. Briefly, the endothelium and Descemet's membrane were peeled off of the stroma and after overnight stabilization at 37° C. in Opti-MEMO media (Gibco, Life Technologies Corp, Carlsbad, CA), supplemented with 8% fetal bovine serum (FBS), they were incubated for 1 hr at 37° C. with ethylenediaminetetraacetic acid (EDTA) to loosen up the cell-cell interactions. Cells were then mechanically dissociated to obtain a single-cell suspension, they were seeded onto FNC-coated culture wells and labeled as “P0” (passage zero). After reaching confluency, they were trypsinized and further expanded into more wells to increase their number. After one or two rounds of expansion, cells were collected and incubated with different antibodies as indicated below. Keratocytes were also obtained from cadaveric donor corneas using the method described by Stramer et al. in “Monoclonal antibody (3G5)-defined ganglioside: cell surface marker of corneal keratocytes,” Invest. Ophthalmol. Vis. Sci. 2004 vol. 45 no. 3 807-812. While one of the HCEC cultures preserved its typical cobblestone morphology at passage 2 (FIG. 1A), a second culture underwent endothelial-to-mesenchymal transition during passage 3 (P3) and the cells became fibroblastic (FIG. 1B). Such cells are generally referred to herein as human corneal endothelial cells of lower utility (e.g., HCECs that have undergone fibroblastic or mesenchymal transformation, etc.) The keratocyte culture exhibits the typical fibroblastic, elongated cell morphology (FIG. 1C).

HCECs from each culture and keratocytes were collected and incubated with one or more of the following labelled antibodies: (a) APC-CD56 which is a mouse monoclonal antibody against a protein product of gene X15 from Table 2 (referred herein to as CD56 surface protein) coupled to allophycocyanin (BD Biosciences, #555518), (b) PE-CD166, which is a mouse monoclonal antibody against a protein product of gene X1 from Table 2 (referred here to as CD166 surface protein) coupled to phycoerythin (BD Biosciences #559263), (c) FITC-CAR, which is a mouse monoclonal antibody against a protein product of gene X25 from Table 2 (referred to as CAR surface protein) coupled to fluorescein-5-Isothiocyanate (Santa Cruz Biotechnology, Santa Cruz, California, USA #sc-56892) and (d) PECy7-CD90, which is a mouse monoclonal antibody against a protein product of gene Z8 from Table 2 (referred to as CD90 surface protein) coupled to a tandem conjugate of PE (energy donor) which has an excitation wavelength of 565 nm and Cy7 (energy acceptor) which has an emission wavelength of 778 nm) (BD Biosciences #561558).

Expression of surface markers was analyzed using a BD LSR™ II flow cytometry system (BD Biosciences, San Jose, CA). The data shown in FIG. 2 are representative from one experiment. Similar results were obtained upon repeated experimentation. Quantification of the % positive cells for each marker shows that in fibroblastic cultures there is a decreased expression of CD56 and CAR, indicating that antibodies to these proteins may be used in conjunction with positive affinity reagents for “good” HCECs. A significant difference in the expression of CD166 or CD90 was not detected using this particular antibody.

FIGS. 3A-3C are dual-color fluorescence dot plots of the HCECs and keratocytes. These dot plots show the differential expression of two surface markers in each cell population as labeled. The percent of cells positive for an individual marker is shown in FIG. 2.

Example 2

HCECs were isolated from cadaveric donor corneas as described in Example 1. Also as discussed in Example 1, HCEC cultures were obtained (a) which evidenced a typical cobblestone morphology (referred to in this Example 2 as a “canonical” cell culture), (b) where all the cells had undergone an endothelial-to-mesenchymal transition (referred to in this Example as a “fibroblastic” cell culture) and (c) where some HCECs had undergone endothelial-to-mesenchymal transition (referred to in this Example as a “mixed” cell culture).

HCEC surface markers were identified by microarray data, and several with high expression in the endothelium (cultured and freshly dissected) but low expression in stroma were selected to be tested by flow cytometry analysis. In addition to APC-CD56, PE-CD166, FITC-CAR and PECy7-CD90 described in Example 1, also tested were (e) CD109-PE, (i.e., mouse anti-CD109), which is a monoclonal antibody against a protein product of gene Y6 from Table 2 (referred to as CD109 antigen) conjugated to phycoerythrin (PE), BD Biosciences Cat #556040 and (f) CD 248-BV, (i.e., mouse anti-Endosialin), which is an unconjugated monoclonal antibody against a protein product of gene X5 from Table 2 (referred to as CD248 antigen or Endosialin), (Millipore, Temecula, CA, USA, Cat #MAB2626), incubated with Goat polyclonal anti-Mouse IgG secondary antibody conjugated to Brilliant Violent 421 (Biolegend, Inc., San Diego, CA, USA, Cat #405317).

To address whether the expression of those markers in HCECs were affected by the fibroblastic conversion described above, HCEC cultures demonstrating two different morphologies (canonical and fibroblastic) and a corneal keratocyte culture as a control were immunostained for the surface proteins CD90, CAR, CD56 and CD166 (See Example 1, FIG. 2). CD56, CAR, CD109 and CD248 expression was also compared between canonical (good), mixed, and fibroblastic HCECs (see FIGS. 4A-4D and 5). Analysis of the percentage of cells expressing any of the individual markers in canonical and fibroblastic cultures demonstrated that CD56, CAR and CD248 expression was reduced in the fibroblastic culture (see FIG. 5), while CD109 was elevated (see FIG. 5); CD90 and CD166 expression did not significantly change between good/canonical and fibroblastic cultures (see Example 1, FIG. 2). A comparable trend was observed in the keratocyte culture used as control for CD90, CAR, CD56 and CD166 expression (see Example 1, FIG. 2).

Dot plot dual histograms of canonical, mixed and fibroblastic cultures shown in FIGS. 6A-6C demonstrated that canonical HCECs are predominantly CD56, CD248 and CAR positive, and CD109 negative; CD56 and CD248 expression is lost and CD109 expression increases as the culture becomes fibroblastic.

Finally, trans-endothelial electrical resistance (TEER) of cell cultures was measured. HCECs (a) from “good” or “canonical” cultures that expressed high levels of CD56, (b) from mixed cultures and (c) from fibroblastic cultures were plated onto inserts with 0.4 mm pores in 24-well culture plates (Transwell, Corning Costar, Acton, MA) at a density of 20,000 cells/insert and incubated in growth media as described in Example 1. TEER was measured using an EVOM volt-ohm meter with STX2 Electrode (World Precision Instrument, Inc., Sarasota, FL) for up to 65 days after initial plating. TEER measures the apical and basal plasma membrane resistance and the paracellular resistance and is used as an index of monolayer confluence integrity of tight junctions. To calculate final resistance (Ω·cm2), the resistance of blank filters were subtracted from those of filters with cells. Four wells per condition were averaged. HCECs exhibiting a canonical morphology and being CD56-positive demonstrated a superior barrier formation ability measured by TEER (FIG. 7).

Thus, we have identified a panel of surface makers that can be used to characterize a canonical and functionally superior HCEC culture, and may be used as quality control criteria or to potentially separate the best HCEC subpopulations for expansion.

Although various embodiments are specifically illustrated and described herein, it will be appreciated that modifications and variations of the present invention are covered by the above teachings and are within the purview of any appended claims without departing from the spirit and intended scope of the invention.

APPENDIX A

TABLE 2
Gene ID:	X1
Gene symbol:	ALCAM
Gene description:	activated leukocyte cell adhesion molecule
Unigene:	Hs.591293
Genbank:	DQ486139
Entrez Gene:	214
Refseq:	NM_001627

Protein sequence (SEQ ID NO (1)):

1	meskgasscr llfcllisat vfrpglgwyt vnsaygdtii ipcrldvpqn lmfgkwkyek
61	pdgspvfiaf rsstkksvqy ddvpeykdrl nlsenytlsi snarisdekr fvcmlvtedn
121	vfeaptivkv fkqpskpeiv skalfleteq lkklgdcise dsypdgnitw yrngkvlhpl
181	egavviifkk emdpvtqlyt mtstleyktt kadiqmpftc svtyygpsgq ktihseqavf
241	diyypteqvt iqvlppknai kegdnitlkc lgngnpppee flfylpgqpe girssntytl
301	tdvrrnatgd ykcslidkks miastaitvh yldlslnpsg evtrqigdal pvsctisasr
361	natvvwmkdn irlrsspsfs slhyqdagny vcetalqeve glkkresltl ivegkpqikm
421	tkktdpsgls ktiichvegf pkpaiqwtit gsgsvinqte espyingryy skiiispeen
481	vtltctaenq lertvnslnv saisipehde adeisdenre kvndqakliv givvglllaa
541	lvagvvywly mkksktaskh vnkdlgnmee nkkleennhk tea
Gene ID:	X2
Gene symbol:	ATP1A1
Gene description:	sodium/potassium-transporting ATPase subunit alpha-1
Unigene:	Hs.371889
Genbank:	BC003077
Entrez Gene:	476
Refseq:	NM_000701|NM_001160233|NM_001160234

Protein sequence isoform a (SEQ ID NO (2)):

1	mgkgvgrdky epaavseqgd kkgkkgkkdr dmdelkkevs mddhklslde lhrkygtdls
61	rgltsaraae ilardgpnal tpppttpewi kfcrqlfggf smllwigail cflaysiqaa
121	teeepqndnl ylgvvlsavv iitgcfsyyq eaksskimes fknmvpqqal virngekmsi
181	naeevvvgdl vevkggdrip adlriisang ckvdnssltg esepqtrspd ftnenpletr
241	niaffstncv egtargivvy tgdrtvmgri atlasglegg qtpiaaeieh fihiitgvav
301	flgvsffils lileytwlea vifligiiva nvpegllatv tvcltltakr marknclvkn
361	leavetlgst sticsdktgt ltqnrmtvah mwfdnqihea dttenqsgvs fdktsatwla
421	lsriaglcnr avfqanqenl pilkravagd asesallkci elccgsvkem reryakivei
481	pfnstnkyql sihknpntse pqhllvmkga perildress illhgkeqpl deelkdafqn
541	aylelgglge rvlgfchlfl pdeqfpegfq fdtddvnfpi dnlcfvglis midppraavp
601	davgkcrsag ikvimvtgdh pitakaiakg vgiisegnet vediaarlni pvsqvnprda
661	kacvvhgsdl kdmtseqldd ilkyhteivf artspqqkli ivegcqrqga ivavtgdgvn
721	dspalkkadi gvamgiagsd vskqaadmil lddnfasivt gveegrlifd nlkksiaytl
781	tsnipeitpf lifiianipl plgtvtilci dlgtdmvpai slayeqaesd imkrqprnpk
841	tdklvnerli smaygqigmi qalggfftyf vilaengflp ihllglrvdw ddrwindved
901	sygqqwtyeq rkiveftcht affvsivvvq wadlvicktr rnsvfqqgmk nkilifglfe
961	etalaaflsy cpgmgvalrm yplkptwwfc afpysllifv ydevrkliir rrpggwveke
1021	tyy

Protein sequence isoform c (SEQ ID NO (3)):

1	mafkvgrdky epaavseqgd kkgkkgkkdr dmdelkkevs mddhklslde lhrkygtdls
61	rgltsaraae ilardgpnal tpppttpewi kfcrqlfggf smllwigail cflaysiqaa
121	teeepqndnl ylgvvlsavv iitgcfsyyq eaksskimes fknmvpqqal virngekmsi
181	naeevvvgdl vevkggdrip adlriisang ckvdnssltg esepqtrspd ftnenpletr
241	niaffstncv egtargivvy tgdrtvmgri atlasglegg qtpiaaeieh fihiitgvav
301	flgvsffils lileytwlea vifligiiva nvpegllatv tvcltltakr marknclvkn
361	leavetlgst sticsdktgt ltqnrmtvah mwfdnqihea dttenqsgvs fdktsatwla
421	lsriaglcnr avfqanqenl pilkravagd asesallkci elccgsvkem reryakivei
481	pfnstnkyql sihknpntse pqhllvmkga perildress illhgkeqpl deelkdafqn
541	aylelgglge rvlgfchifl pdeqfpegfq fdtddvnfpi dnlcfvglis midppraavp
601	davgkcrsag ikvimvtgdh pitakaiakg vgiisegnet vediaarlni pvsqvnprda
661	kacvvhgsdl kdmtseqldd ilkyhteivf artspqqkli ivegcqrqga ivavtgdgvn
721	dspalkkadi gvamgiagsd vskqaadmil lddnfasivt gveegrlifd nlkksiaytl
781	tsnipeitpf lifiianipl plgtvtilci dlgtdmvpai slayeqaesd imkrqprnpk
841	tdklvnerli smaygqigmi qalggfftyf vilaengflp ihllglrvdw ddrwindved
901	sygqqwtyeq rkiveftcht affvsivvvq wadlvicktr rnsvfqqgmk nkilifglfe
961	etalaaflsy cpgmgvalrm yplkptwwfc afpysllifv ydevrkliir rrpggwveke
1021	tyy

Protein sequence isoform d (SEQ ID NO (4)):

1	mdelkkevsm ddhklsldel hrkygtdlsr gltsaraaei lardgpnalt pppttpewik
61	fcrqlfggfs mllwigailc flaysiqaat eeepqndnly lgvvlsavvi itgcfsyyqe
121	aksskimesf knmvpqqalv irngekmsin aeevvvgdlv evkggdripa dlriisangc
181	kvdnssltge sepqtrspdf tnenpletrn iaffstncve gtargivvyt gdrtvmgria
241	tlasgleggq tpiaaeiehf ihiitgvavf lgvsffilsl ileytwleav ifligiivan
301	vpegllatvt vcltltakrm arknclvknl eavetlgsts ticsdktgtl tqnrmtvahm
361	wfdnqihead ttenqsgvsf dktsatwlal sriaglcnra vfqanqenlp ilkravagda
421	sesallkcie lccgsvkemr eryakiveip fnstnkyqls ihknpntsep qhllvmkgap
481	erildrcssi llhgkeqpld eelkdafqna ylelgglger vlgfchlflp deqfpegfqf
541	dtddvnfpid nlcfvglism idppraavpd avgkcrsagi kvimvtgdhp itakaiakgv
601	giisegnetv ediaarlnip vsqvnprdak acvvhgsdlk dmtseqlddi lkyhteivfa
661	rtspqqklii vegcqrqgai vavtgdgvnd spalkkadig vamgiagsdv skqaadmill
721	ddnfasivtg veegrlifdn lkksiaytlt snipeitpfl ifiianiplp lgtvtilcid
781	lgtdmvpais layeqaesdi mkrqprnpkt dklvnerlis maygqigmiq alggfftyfv
841	ilaengflpi hllglrvdwd drwindveds ygqqwtyeqr kiveftchta ffvsivvvqw
901	adlvicktrr nsvfqqgmkn kilifglfee talaaflsyc pgmgvalrmy plkptwwfca
961	fpysllifvy devrkliirr rpggwveket yy
Gene ID:	X3
Gene symbol:	CD200
Gene description:	CD 200 molecule
Unigene:	Hs.79015
Genbank:	AK297194|AF063591|BC022522|BC031103|AY603771|AK293399
Entrez Gene:	4345
Refseq:	NM_001004196|NM_005944

Protein sequence isoform b (SEQ ID NO (5)):

1	merltltrti ggplltatll gkttindyqv irmpfshlst yslvwvmaav vlctaqvqvv
61	tqdereqlyt paslkcslqn aqealivtwq kkkavspenm vtfsenhgvv iqpaykdkin
121	itqlglqnst itfwnitled egcymclfnt fgfgkisgta cltvyvqpiv slhykfsedh
181	lnitcsatar papmvfwkvp rsgienstvt lshpngttsv tsilhikdpk nqvgkevicq
241	vlhlgtvtdf kqtvnkgywf svplllsivs lvillvlisi llywkrhrnq drep

Protein sequence isoform a (SEQ ID NO (6)):

1	merlvirmpf shlstyslvw vmaavvlcta qvqvvtqder eqlytpaslk cslqnaqeal
61	ivtwqkkkav spenmvtfse nhgvviqpay kdkinitqlg lqnstitfwn itledegcym
121	clfntfgfgk isgtacltvy vqpivslhyk fsedhlnitc satarpapmv fwkvprsgie
181	nstvtlshpn gttsvtsilh ikdpknqvgk evicqvlhlg tvtdfkqtvn kgywfsvpll
241	lsivslvill vlisillywk rhrnqdrep
Gene ID:	X4
Gene symbol:	LAMB1
Gene description:	laminin, beta 1
Unigene:	Hs.650585
Genbank:	M61916
Entrez Gene:	3912
Refseq:	NM_002291

Protein sequence (SEQ ID NO (7)):

1	mgllqllafs flalcrarvr aqepefsygc aegscypatg dlligraqkl svtstcglhk
61	pepycivshl qedkkcficn sqdpyhetln pdshlienvv ttfapnrlki wwqsengven
121	vtiqldleae fhfthlimtf ktfrpaamli erssdfgktw gvyryfaydc easfpgistg
181	pmkkvddiic dsrysdieps tegevifral dpafkiedpy spriqnllki tnlrikfvkl
241	htlgdnllds rmeirekyyy avydmvvrgn cfcyghasec apvdgfneev egmvhghcmc
301	rhntkglnce lcmdfyhdlp wrpaegrnsn ackkcncneh sischfdmav ylatgnvsgg
361	vcddcqhntm grnceqckpf yyqhperdir dpnfcerctc dpagsqnegi cdsytdfstg
421	liagqcrckl nvegehcdvc kegfydisse dpfgckscac nplgtipggn pcdsetghcy
481	ckrlvtgqhc dqclpehwgl sndldgerpc dcdlggalnn scfaesgqcs crphmigrqc
541	nevepgyyfa tldhylyeae eanlgpgvsi verqyiqdri pswtgagfvr vpegayleff
601	idnipysmey diliryepql pdhwekavit vqrpgripts srcgntipdd dnqvvslspg
661	sryvvlprpv cfekgtnytv rlelpqytss dsdvespytl idslvlmpyc ksldiftvgg
721	sgdgvvtnsa wetfqryrcl ensrsvvktp mtdvcrniif sisallhqtg lacecdpqgs
781	lssvcdpngg qcqcrpnvvg rtcnrcapgt fgfgpsgckp cechlqgsvn afcnpvtgqc
841	hcfqgvyarq cdrclpghwg fpscqpcqcn ghaddcdpvt geclncqdyt mghncercla
901	gyygdpiigs gdherpcpcp dgpdsgrqfa rscyqdpvtl qlacvcdpgy igsreddcas
961	gyfgnpsevg gscqpcqchn nidttdpeac dketgrclkc lyhtegehcq fcrfgyygda
1021	lqqdcrkcvc nylgtvqehc ngsdcqcdka tgqclclpnv igqncdrcap ntwqlasgtg
1081	cdpcncnaah sfgpscneft gqcqcmpgfg grtcsecqel fwgdpdvecr acdcdprgie
1141	tpqcdqstgq cvcvegvegp redkctrgys gvfpdctpch qcfalwdvii aeltnrthrf
1201	lekakalkis gvigpyretv dsverkvsei kdilaqspaa eplknignlf eeaeklikdv
1261	temmaqvevk lsdttsqsns takeldslqt eaesldntvk elaeqlefik nsdirgalds
1321	itkyfqmsle aeervnastt epnstveqsa lmrdrvedvm meresqfkek qeeqarllde
1381	lagklqsldl saaaemtcgt ppgascsete cggpncrtde gerkcggpgc gglvtvahna
1441	wqkamdldqd vlsalaeveq lskmvseakl radeakqsae dillktnatk ekmdksneel
1501	rnlikqirnf ltqdsadlds ieavanevlk mempstpqql qnltedirer veslsqvevi
1561	lqhsaadiar aemlleeakr asksatdvkv tadmvkeale eaekaqvaae kaikqadedi
1621	qgtqnlltsi esetaaseet lfnasqrise lernveelkr kaaqnsgeae yiekvvytvk
1681	qsaedvkktl dgeldekykk venliakkte esadarrkae mlqneaktll aqansklqll
1741	kdlerkyedn qryledkaqe larlegevrs llkdisqkva vystcl
Gene ID:	X5
Gene symbol:	CD248
Gene description:	endosialin
Unigene:	Hs.195727
Genbank:	AF279142
Entrez Gene:	57124
Refseq:	NM_020404

Protein sequence (SEQ ID NO (8)):

1	mllrlllawa aagptlgqdp waaepraacg psscyalfpr rrtfleawra crelggdlat
61	prtpeeaqrv dslvgagpas rllwiglqrq arqcqlqrpl rgftwttgdq dtaftnwaqp
121	asggpcpaqr cvaleasgeh rwlegsctla vdgylcqfgf egacpalqde agqagpavyt
181	tpfhlvstef ewlpfgsvaa vqcqagrgas llcvkqpegg vgwsragplc lgtgcspdng
241	gcehecveev dghvscrcte gfrlaadgrs cedpcaqapc eqqcepggpq gyschcrlgf
301	rpaeddphrc vdtdecqiag vcqqmcvnyv ggfecycseg heleadgisc spagamgaqa
361	sqdlgdelld dgedeedede awkafnggwt empgilwmep tqppdfalay rpsfpedrep
421	qipypeptwp pplsaprvpy hssvlsvtrp vvvsathptl psahqppvip athpalsrdh
481	qipviaanyp dlpsayqpgi lsvshsaqpp ahqppmistk ypelfpahqs pmfpdtrvag
541	tqttthlpgi ppnhaplvtt lgaqlppqap dalvlrtqat qlpiiptaqp sltttsrspv
601	spahqisvpa atqpaalptl lpsqsptnqt spispthphs kapqipredg pspklalwlp
661	spaptaapta lgeaglaehs qrddrwllva llvptcvflv vllalgivyc trcgphapnk
721	ritdcyrwvi hagsksptep mpprgsltgv qtcrtsv
Gene ID:	X6
Gene symbol:	COL4A6
Gene description:	collagen, type IV, alpha 6
Unigene:	Hs.145586
Genbank:	D21337
Entrez Gene:	1288
Refseq:	NM_033641|NM_001847

Protein sequence isoform b (SEQ ID NO (9)):

1	mhpglwlllv tlclteelaa ageksygkpc ggqdcsgscq cfpekgargr pgpigiqgpt
61	gpqgftgstg lsglkgergf pgllgpygpk gdkgpmgvpg flgingipgh pgqpgprgpp
121	gldgcngtqg avgfpgpdgy pgllgppglp gqkgskgdpv lapgsfkgmk gdpglpgldg
181	itgpqgapgf pgavgpagpp glqgppgppg plgpdgnmgl gfqgekgvkg dvglpgpagp
241	ppstgelefm gfpkgkkgsk gepgpkgfpg isgppgfpgl gttgekgekg ekgipglpgp
301	rgpmgsegvq gppgqqgkkg tlgfpglngf qgiegqkgdi glpgpdvfid idgavisgnp
361	gdpgvpglpg lkgdegiqgl rgpsgvpglp alsgvpgalg pqgfpglkgd qgnpgrttig
421	aaglpgrdgl pgppgppgpp spefetetlh nkesgfpglr geqgpkgnlg lkgikgdsgf
481	cacdggvpnt gppgepgppg pwgliglpgl kgargdrgsg gaqgpagapg lvgplgpsgp
541	kgkkgepils tiqgmpgdrg dsgsqgfrgv igepgkdgvp glpglpglpg dggqgfpgek
601	glpglpgekg hpgppglpgn glpglpgprg lpgdkgkdgl pgqqglpgsk gitlpciipg
661	sygpsgfpgt pgfpgpkgsr glpgtpgqpg ssgskgepgs pglvhlpelp gfpgprgekg
721	lpgfpglpgk dglpgmigsp glpgskgatg difgaengap geqglqgltg hkgflgdsgl
781	pglkgvhgkp gllgpkgerg spgtpgqvgq pgtpgssgpy gikgksglpg apgfpgisgh
841	pgkkgtrgkk gppgsivkkg lpglkglpgn pglvglkgsp gspgvaglpa lsgpkgekgs
901	vgfvgfpgip glpgipgtrg lkgipgstgk mgpsgragtp gekgdrgnpg pvgipsprrp
961	msnlwlkgdk gsqgsagsng fpgprgdkge agrpgppglp gapglpgiik gvsgkpgppg
1021	fmgirglpgl kgssgitgfp gmpgesgsqg irgspglpga sglpglkgdn gqtveisgsp
1081	gpkgqpgesg fkgtkgrdgl ignigfpgnk gedgkvgvsg dvglpgapgf pgvagmrgep
1141	glpgssghqg aigplgspgl igpkgfpgfp glhglnglpg tkgthgtpgp sitgvpgpag
1201	lpgpkgekgy pgigigapgk pglrgqkgdr gfpglqgpag lpgapgislp sliagqpgdp
1261	grpgldgerg rpgpagppgp pgpssnqgdt gdpgfpgipg pkgpkgdqgi pgfsglpgel
1321	glkgmrgepg fmgtpgkvgp pgdpgfpgmk gkagprgssg lqgdpgqtpt aeavqvppgp
1381	lglpgidgip gltgdpgaqg pvglqgskgl pgipgkdgps glpgppgalg dpglpglqgp
1441	pgfegapgqq gpfgmpgmpg qsmrvgytlv khsqseqvpp cpigmsqlwv gysllfvegq
1501	ekahnqdlgf agsclprfst mpfiycnine vchyarrndk sywlsttapi pmmpvsqtqi
1561	pqyisrcsvc eapsqaiavh sqditipqcp lgwrslwigy sflmhtaaga egggqslvsp
1621	gscledfrat pfiecsgarg tchyfankys fwlttveerq qfgelpvset lkagqlhtrv
1681	srcqvcmksl

Protein sequence isoform a (SEQ ID NO (10)):

1	mlinklwlll vtlclteela aageksygkp cggqdesgsc qcfpekgarg rpgpigiqgp
61	tgpqgftgst glsglkgerg fpgllgpygp kgdkgpmgvp gflgingipg hpgqpgprgp
121	pgldgcngtq gavgfpgpdg ypgllgppgl pgqkgskgdp vlapgsfkgm kgdpglpgld
181	gitgpqgapg fpgavgpagp pglqgppgpp gplgpdgnmg lgfqgekgvk gdvglpgpag
241	pppstgelef mgfpkgkkgs kgepgpkgfp gisgppgfpg lgttgekgek gekgipglpg
301	prgpmgsegv qgppgqqgkk gtlgfpglng fqgiegqkgd iglpgpdvfi didgavisgn
361	pgdpgvpglp glkgdegiqg lrgpsgvpgl palsgvpgal gpqgfpglkg dqgnpgrtti
421	gaaglpgrdg lpgppgppgp pspefetetl hnkesgfpgl rgeqgpkgnl glkgikgdsg
481	fcacdggvpn tgppgepgpp gpwgliglpg lkgargdrgs ggaqgpagap glvgplgpsg
541	pkgkkgepil stiqgmpgdr gdsgsqgfrg vigepgkdgv pglpglpglp gdggqgfpge
601	kglpglpgek ghpgppglpg nglpglpgpr glpgdkgkdg lpgqqglpgs kgitlpciip
661	gsygpsgfpg tpgfpgpkgs rglpgtpgqp gssgskgepg spglvhlpel pgfpgprgek
721	glpgfpglpg kdglpgmigs pglpgskgat gdifgaenga pgeqglqglt ghkgflgdsg
781	lpglkgvhgk pgllgpkger gspgtpgqvg qpgtpgssgp ygikgksglp gapgfpgisg
841	hpgkkgtrgk kgppgsivkk glpglkglpg npglvglkgs pgspgvaglp alsgpkgekg
901	svgfvgfpgi pglpgipgtr glkgipgstg kmgpsgragt pgekgdrgnp gpvgipsprr
961	pmsnlwlkgd kgsqgsagsn gfpgprgdkg eagrpgppgl pgapglpgii kgvsgkpgpp
1021	gfmgirglpg lkgssgitgf pgmpgesgsq girgspglpg asglpglkgd ngqtveisgs
1081	pgpkgqpges gfkgtkgrdg lignigfpgn kgedgkvgvs gdvglpgapg fpgvagmrge
1141	pglpgssghq gaigplgspg ligpkgfpgf pglhginglp gtkgthgtpg psitgvpgpa
1201	glpgpkgekg ypgigigapg kpglrgqkgd rgfpglqgpa glpgapgisl psliagqpgd
1261	pgrpgldger grpgpagppg ppgpssnqgd tgdpgfpgip gpkgpkgdqg ipgfsglpge
1321	lglkgmrgep gfmgtpgkvg ppgdpgfpgm kgkagprgss glqgdpgqtp taeavqvppg
1381	plglpgidgi pgltgdpgaq gpvglqgskg lpgipgkdgp sglpgppgal gdpglpglqg
1441	ppgfegapgq qgpfgmpgmp gqsmrvgytl vkhsqseqvp pcpigmsqlw vgysllfveg
1501	qekahnqdlg fagsclprfs tmpfiycnin evchyarrnd ksywlsttap ipmmpvsqtq
1561	ipqyisrcsv ceapsqaiav hsqditipqc plgwrslwig ysflmhtaag aegggqslvs
1621	pgscledfra tpfiecsgar gtchyfanky sfwlttveer qqfgelpvse tlkagqlhtr
1681	vsrcqvcmks l
Gene ID:	X7
Gene symbol:	PCDH7
Gene description:	protocadherin 7
Unigene:	Hs.479439|Hs.724529
Genbank:	AB006755
Entrez Gene:	5099
Refseq:	NM_032456|NM_002589|NM_032457|NM_001173523

Protein sequence isoform b (SEQ ID NO (11)):

1	mlrmrtagwa rgwclgccll lplslslaaa kqllryrlae egpadvrign vasdlgivtg
61	sgevtfsles gseylkidnl tgelstserr idreklpqcq mifdenecfl dfevsvigps
121	qswvdlfegq vivldindnt ptfpspvltl tveenrpvgt lyllptatdr dfgrngiery
181	ellqepgggg sggesrraga adsapypggg gngasgggsg gskrrldase ggggtnpggr
241	ssvfelqvad tpdgekqpql ivkgaldreq rdsyeltlrv rdggdpprss qailmvlitd
301	vndnsprfek svyeadlaen sapgtpilql raadldvgvn gqieyvfgaa tesvrrllrl
361	detsgwlsvl hridreevnq lrftvmardr gqppktdkat vvlnikdend nvpsieirki
421	griplkdgva nvaedvlvdt pialvqvsdr dqgengvvtc twvgdvpfql kpasdtegdq
481	nkkkyflhts tpldyeatre fnvvivavds gspslssnns livkvgdtnd nppmfgqsvv
541	evyfpennip gervatvlat dadsgknaei aysldssvmg ifaidpdsgd ilvntvldre
601	qtdryefkvn akdkgipvlq gsttvivqva dkndndpkfm qdvftfyvke nlqpnspvgm
661	vtvmdadkgr naemslyiee nnnifsiend tgtiystmsf drehqttytf rvkavdggdp
721	prsatatvsl fvmdendnap tvtlpknisy tllppssnvr tvvatvlatd sddginadln
781	ysivggnpfk lfeidptsgv vslvgkltqk hyglhrlvvq vndsgqpsqs tttlvhvfvn
841	esvsnataid sqiarslhip ltqdiagdps yeiskqrlsi vigvvagimt viliilivvm
901	arycrsknkn gyeagkkdhe dfftpqqhdk skkpkkdkkn kkskqplyss ivtveaskpn
961	gqrydsvnek lsdspsmgry rsvnggpgsp dlarhyksss plptvqlhpq sptagkkhqa
1021	vqdlppantf vgagdnisig sdhcseyscq tnnkyskqvr cipnifkypr eg

Protein sequence isoform a (SEQ ID NO (12)):

1	mlrmrtagwa rgwclgccll lplslslaaa kqllrynlae egpadvrign vasdlgivtg
61	sgevtfsles gseylkidnl tgelstserr idreklpqcq mifdenecfl dfevsvigps
121	qswvdlfegq vivldindnt ptfpspvltl tveenrpvgt lyllptatdr dfgrngiery
181	ellqepgggg sggesrraga adsapypggg gngasgggsg gskrrldase ggggtnpggr
241	ssvfelqvad tpdgekqpql ivkgaldreq rdsyeltlrv rdggdpprss qailrvlitd
301	vndnsprfek svyeadlaen sapgtpilql raadldvgvn gqieyvfgaa tesvrrllrl
361	detsgwlsvl hridreevnq lrftvmardr gqppktdkat vvlnikdend nvpsieirki
421	griplkdgva nvaedvlvdt pialvqvsdr dqgengvvtc twvgdvpfql kpasdtegdq
481	nkkkyflhts tpldyeatre fnvvivavds gspslssnns livkvgdtnd nppmfgqsvv
541	evyfpennip gervatvlat dadsgknaei aysldssvmg ifaidpdsgd ilvntvldre
601	qtdryefkvn akdkgipvlq gsttvivqva dkndndpkfm qdvftfyvke nlqpnspvgm
661	vtvmdadkgr naemslyiee nnnifsiend tgtiystmsf drehqttytf rvkavdggdp
721	prsatatvsl fvmdendnap tvtlpknisy tllppssnvr tvvatvlatd sddginadln
781	ysivggnpfk lfeidptsgv vslvgkltqk hyglhrlwvq vndsgqpsqs tttlvhvfvn
841	esvsnataid sqiarslhip ltqdiagdps yeiskqrlsi vigvvagimt viliilivvm
901	arycrsknkn gyeagkkdhe dfftpqqhdk skkpkkdkkn kkskqplyss ivtveaskpn
961	gqrydsvnek lsdspsmgry rsvnggpgsp dlarhyksss plptvqlhpq sptagkkhqa
1021	vqdlppantf vgagdnisig sdhcseyscq tnnkyskqmr lhpyitvfg

Protein sequence isoform c (SEQ ID NO (13)):

1	mlrmrtagwa rgwclgccll lplslslaaa kqllrynlae egpadvrign vasdlgivtg
61	sgevtfsles gseylkidnl tgelstserr idreklpqcq mifdenecfl dfevsvigps
121	qswvdlfegq vivldindnt ptfpspvltl tveenrpvgt lyllptatdr dfgrngiery
181	ellqepgggg sggesrraga adsapypggg gngasgggsg gskrrldase ggggtnpggr
241	ssvfelqvad tpdgekqpql ivkgaldreq rdsyeltlrv rdggdpprss qailrvlitd
301	vndnsprfek svyeadlaen sapgtpilql raadldvgvn gqieyvfgaa tesvrrllrl
361	detsgwlsvl hridreevnq lrftvmardr gqppktdkat vvlnikdend nvpsieirki
421	griplkdgva nvaedvlvdt pialvqvsdr dqgengvvtc tvvgdvpfql kpasdtegdq
481	nkkkyflhts tpldyeatre fnvvivavds gspslssnns livkvgdtnd nppmfgqsvv
541	evyfpennip gervatvlat dadsgknaei aysldssvmg ifaidpdsgd ilvntvldre
601	qtdryefkvn akdkgipvlq gsttvivqva dkndndpkfm qdvftfyvke nlqpnspvgm
661	vtvmdadkgr naemslyiee nnnifsiend tgtiystmsf drehqttytf rvkavdggdp
721	prsatatvsl fvmdendnap tvtlpknisy tllppssnvr tvvatvlatd sddginadln
781	ysivggnpfk lfeidptsgv vslvgkltqk hyglhrlvvq vndsgqpsqs tttlvhvfvn
841	esvsnataid sqiarslhip ltqdiagdps yeiskqrlsi vigvvagimt viliilivvm
901	arycrsknkn gyeagkkdhe dfftpqqhdk skkpkkdkkn kkskqplyss ivtveaskpn
961	gqrydsvnek lsdspsmgry rsvnggpgsp dlarhyksss plptvqlhpq sptagkkhqa
1021	vqdlppantf vgagdnisig sdhcseyscq tnnkyskqpf rrvtfsvvsq pqdphqgslq
1081	scydsglees etpssksssg prlgalplpe dnyerttpdg svdsrplpdv altgkctrec
1141	deyghsdscw mpvrtsperk ksqpklstfm pvdergsqek langeaaimg drnrnllnkk
1201	ltssyetfsa asfskneean pedipltktg eykpspvntl trrevyl

Protein sequence isoform d (SEQ ID NO (14)):

1	mlrmrtagwa rgwclgccll lplslslaaa kqllryrlae egpadvrign vasdlgivtg
61	sgevtfsles gseylkidnl tgelstserr idreklpqcq mifdenecfl dfevsvigps
121	qswvdlfegq vivldindnt ptfpspvltl tveenrpvgt lyllptatdr dfgrngiery
181	ellqepgggg sggesrraga adsapypggg gngasgggsg gskrrldase ggggtnpggr
241	ssvfelqvad tpdgekqpql ivkgaldreq rdsyeltlrv rdggdpprss qailrvlitd
301	vndnsprfek svyeadlaen sapgtpilql raadldvgvn gqieyvfgaa tesvrrllrl
361	detsgwlsvl hridreevnq lrftvmardr gqppktdkat vvlnikdend nvpsieirki
421	griplkdgva nvaedvlvdt pialvqvsdr dqgengvvtc tvvgdvpfql kpasdtegdq
481	nkkkyflhts tpldyeatre fnvvivavds gspslssnns livkvgdtnd nppmfgqswv
541	evyfpennip gervatvlat dadsgknaei aysldssvmg ifaidpdsgd ilvntvldre
601	qtdryefkvn akdkgipvlq gsttvivqva dkndndpkfm qdvftfyvke nlqpnspvgm
661	vtvmdadkgr naemslyiee nnnifsiend tgtiystmsf drehqttytf rvkavdggdp
721	prsatatvsl fvmdendnap tvtlpknisy tllppssnvr tvvatvlatd sddginadln
781	ysivggnpfk lfeidptsgv vslvgkltqk hyglhrlvvq vndsgqpsqs tttlvhvfvn
841	esvsnataid sqiarslhip ltqdiagdps yeiskqrlsi vigvvagimt viliilivvm
901	arycrsknkn gyeagkkdhe dfftpqqhdk skkpkkdkkn kkskqplyss ivtveaskpn
961	gqrydsvnek lsdspsmgry rsvnggpgsp dlarhyksss plptvqlhpq sptagkkhqa
1021	vqdlppantf vgagdnisig sdhcseyscq tnnkyskqpf rrvtfsvvsq pqdphqgslq
1081	scydsglees etpssksssg prlgalplpe dnyerttpdg svgeaehmen dsrplpdval
1141	tgkctrecde yghsdscwmp vrtsperkks qpklstfmpv dergsqekla ngeaaimgdr
1201	nrnllnkklt ssyetfsaas fskneeanpe dipltktgey kpspvntltr revyl
Gene ID:	X8
Gene symbol:	NOG
Gene description:	noggin
Unigene:	Hs.248201
Genbank:	BC034027
Entrez Gene:	9241
Refseq:	NM_005450

Protein sequence (SEQ ID NO (15)):

1	mercpslgvt lyalvvvlgl ratpaggqhy lhirpapsdn lplvdliehp dpifdpkekd
61	lnetllrsll gghydpgfma tsppedrpgg gggaaggaed laeldqllrq rpsgampsei
121	kglefsegla qgkkqrlskk lrrklqmwlw sqtfcpvlya wndlgsrfwp ryvkvgscfs
181	krscsvpegm vckpsksvhl tvlrwrcqrr ggqrcgwipi qypiiseckc sc
Gene ID:	X9
Gene symbol:	SULF1
Gene description:	sulfatase 1
Unigene:	Hs.409602
Genbank:	AF545571
Entrez Gene:	23213
Refseq:	NM_001128205|NM_015170|NM_001128206|NM_001128204

Protein sequence (SEQ ID NO (16)):

1	mkysccalvl avlgtellgs lcstvrsprf rgriqqerkn irpniilvit ddqdvelgsl
61	qvmnktrkim ehggatfina fvttpmccps rssmitgkyv hnhnvytnne ncsspswqam
121	heprtfavyl nntgyrtaff gkylneyngs yippgwrewl gliknsrfyn ytvcrngike
181	khgfdyakdy ftdlitnesi nyfkmskrmy phrpvmmvis haaphgpeds apqfsklypn
241	asqhitpsyn yapnmdkhwi mqytgpmlpi hmeftnilqr kriqtlmsvd dsverlynml
301	vetgelenty iiytadhgyh igqfglvkgk smpydfdirv pffirgpsve pgsivpqivl
361	nidlaptild iagldtppdv dgksvlklld pekpgnrfrt nkkakiwrdt flvergkflr
421	kkeesskniq qsnhlpkyer vkelcqqary qtaceqpgqk wqciedtsgk lrihkckgps
481	dlltvrqstr nlyargfhdk dkecscresg yrasrsqrks qrqflrnqgt pkykprfvht
541	rqtrslsvef egeiydinle eeeelqvlqp rniakrhdeg hkgprdlqas sggnrgrmla
601	dssnavgppt tvrvthkcfi lpndsihcer elyqsarawk dhkayidkei ealqdkiknl
661	revrghlkrr kpeecscskq syynkekgvk kqeklkshlh pfkeaaqevd sklqlfkenn
721	rrrkkerkek rrqrkgeecs lpgltcfthd nnhwqtapfw nlgsfcacts snnntywclr
781	tvnethnflf cefatgfley fdmntdpyql tntvhtverg ilnqlhvqlm elrscqgykq
841	cnprpknldv gnkdggsydl hrgqlwdgwe g
Gene ID:	X10
Gene symbol:	SORT1
Gene description:	sortilin 1
Unigene:	Hs.485195
Genbank:	X98248
Entrez Gene:	6272
Refseq:	NM_002959|NM_001205228

Protein sequence isoform 1 (SEQ ID NO (17)):

1	merpwgaadg lsrwphglgl llllqllpps tlsqdrldap pppaaplprw sgpigvswgl
61	raaaaggafp rggrwrrsap gedeecgrvr dfvaklannt hqhvfddlrg svslswvgds
121	tgvilvlttf hvplvimtfg qsklyrsedy gknfkditdl inntfirtef gmaigpensg
181	kwvltaevsg gsrggrifrs sdfaknfvqt dlpfhpltqm myspqnsdyl lalstenglw
241	vsknfggkwe eihkavclak wgsdntifft tyangsckad lgalelwrts dlgksfktig
301	vkiysfglgg rflfasvmad kdttrrihvs tdqgdtwsma qlpsvgqeqf ysilaanddm
361	vfmhvdepgd tgfgtiftsd drgivysksl drhlytttgg etdftnvtsl rgvyitsvls
421	ednsiqtmit fdqggrwthl rkpensecda taknknecsl hihasysisq klnvpmapls
481	epnavgivia hgsvgdaisv mvpdvyisdd ggyswtkmle gphyytilds ggiivaiehs
541	srpinvikfs tdegqcwqty tftrdpiyft glasepgars mnisiwgfte sfltsqwvsy
601	tidfkdiler nceekdytiw lahstdpedy edgcilgyke qflrlrkssv cqngrdyvvt
661	kqpsiclcsl edflcdfgyy rpendskcve qpelkghdle fclygreehl ttngyrkipg
721	dkcqggvnpv revkdlkkkc tsnflspekq nsksnsvpii laivglmlvt vvagvlivkk
781	yvcggrflvh rysvlqqhae angvdgvdal dtashtnksg yhddsdedll e

Protein sequence isoform 2 (SEQ ID NO (18)):

1	mtfgqsklyr sedygknfkd itdlinntfi rtefgmaigp ensgkvvlta evsggsrggr
61	ifrssdfakn fvqtdlpfhp ltqmmyspqn sdyllalste nglwvsknfg gkweeihkav
121	clakwgsdnt iffttyangs ctdlgalelw rtsdlgksfk tigvkiysfg lggrflfasv
181	madkdttrri hvstdqgdtw smaqlpsvgq eqfysilaan ddmvfmhvde pgdtgfgtif
241	tsddrgivys ksldrhlytt tggetdftnv tslrgvyits vlsednsiqt mitfdqggrw
301	thlrkpense cdataknkne cslhihasys isqklnvpma plsepnavgi viahgsvgda
361	isvmvpdvyi sddggyswtk mlegphyyti ldsggiivai ehssrpinvi kfstdegqcw
421	qtytftrdpi yftglasepg arsmnisiwg ftesfltsqw vsytidfkdi lernceekdy
481	tiwlahstdp edyedgcilg ykeqflrlrk ssveqngrdy vvtkqpsicl csledflcdf
541	gyyrpendsk cveqpelkgh dlefclygre ehlttngyrk ipgdkcqggv npvrevkdlk
601	kkctsnflsp ekqnsksnsv piilaivglm lvtvvagvli vkkyvcggrf lvhrysvlqq
661	haeangvdgv daldtashtn ksgyhddsde dlle
Gene ID:	X11
Gene symbol:	ATP1B1
Gene description:	sodium/potassium-transporting ATPase subunit beta-1
Unigene:	Hs.291196
Genbank:	U16799
Entrez Gene:	481
Refseq:	NM_001677

Protein sequence (SEQ ID NO (19)):

1	margkakeeg swkkfiwnse kkeflgrtgg swfkillfyv ifygclagif igtiqvmllt
61	isefkptyqd rvappgltqi pqiqkteisf rpndpksyea yvlnivrfle kykdsaqrdd
121	mifedcgdvp sepkergdfn hergerkvcr fklewlgncs glndetygyk egkpciiikl
181	nrvlgfkpkp pknesletyp vmkynpnvlp vqctgkrded kdkvgnveyf glgnspgfpl
241	qyypyygkll qpkylqplla vqftnltmdt eirieckayg enigysekdr fqgrfdvkie
301	vks
Gene ID:	X12
Gene symbol:	AGRN
Gene description:	Agrin
Unigene:	Hs.273330
Genbank:	AB191264
Entrez Gene:	375790
Refseq:	NM_198576

Protein sequence (SEQ ID NO (20)):

1	magrshpgpl rpllpllvva acvlpgaggt cperalerre eeanwvltgt veeilnvdpv
61	qhtysckvrv wrylkgkdlv areslldggn kvvisgfgdp licdnqvstg dtriffvnpa
121	ppylwpahkn elmlnsslmr itlrnleeve fcvedkpgth ftpvpptppd acrgmlcgfg
181	avcepnaegp grascvckks pcpsvvapvc gsdastysne celqraqcsq qrrirllsrg
241	pcgsrdpcsn vtcsfgstca rsadgltasc lcpatcrgap egtvcgsdga dypgecqllr
301	racarqenvf kkfdgpcdpc qgalpdpsrs crvnprtrrp emllrpescp arqapvcgdd
361	gvtyendcvm grsgaargll lqkvrsgqcq grdqcpeper fnavelsrrg rprescdrvt
421	cdgayrpvca qdgrtydsdc wrqqaecrqq raipskhqgp cdqapspclg vqcafgatca
481	vkngqaacec lqacsslydp vcgsdgvtyg saceleatac tlgreiqvar kgpedregqc
541	rfgalceaet grcvcpsecv alaqpvcgsd ghtypsecml hvhacthqis lhvasagpce
601	tcgdavcafg avcsagqcvc prcehpppgp vcgsdgvtyg sacelreaac lqqtqieear
661	agpceqaecg sggsgsgedg dceqelcrqr ggiwdedsed gpcvcdfscq svpgspvcgs
721	dgvtystece lkkarcesqr glyvaaqgac rgptfaplpp vaplhcaqtp ygccqdnita
781	argvglagcp sacqcnphgs yggtcdpatg qcscrpgvgg lrcdrcepgf wnfrgivtdg
841	rsgctpcscd pqgavrddce qmtglcsckp gvagpkcgqc pdgralgpag ceadasapat
901	caemrcefga reveesgsah cvcpmltcpe anatkvcgsd gvtygnecql ktiacrqglq
961	isiqslgpcq eavapsthpt sasvtvttpg lllsqalpap pgalplapss tahsqttppp
1021	ssrprttasv prttvwpvlt vpptapspap slvasafges gstdgssdee lsgdqeasgg
1081	gsgglepleg ssvatpgppv erascynsal gccsdgktps ldaegsncpa tkvfqgvlel
1141	egvegqelfy tpemadpkse lfgetarsie stlddlfrns dvkkdfrsvr lrdlgpgksv
1201	raivdvhfdp ttafrapdva rallrqiqvs rrrslgvrrp lqehvrfmdf dwfpafitga
1261	tsgaiaagat arattasrlp ssavtpraph pshtsqpvak ttaapttrrp pttapsrvpg
1321	rrppapqqpp kpcdsqpcfh ggtcqdwalg ggftcscpag rggavcekvl gapvpafegr
1381	sflafptira yhtlrlalef ralepqglll yngnargkdf lalalldgrv qlrfdtgsgp
1441	avltsavpve pgqwhrlels rhwrrgtlsv dgetpvlges psgtdglnld tdlfvggvpe
1501	dqaavalert fvgaglrgci rlldvnnqrl elgigpgaat rgsgvgecgd hpclpnpchg
1561	gapcqnleag rfhcqcppgr vgptcadeks pcqpnpchga apcrvlpegg aqcecplgre
1621	gtfcqtasgq dgsgpfladf ngfshlelrg lhtfardlge kmalevvfla rgpsglllyn
1681	gqktdgkgdf vslalrdrrl efrydlgkga avirsrepvt lgawtrvsle rngrkgalrv
1741	gdgprvlges pvphtvinik eplyvggapd fsklaraaav ssgfdgaiql vslggrqllt
1801	pehvlrqvdv tsfaghpctr asghpclnga scvpreaayv clcpggfsgp hcekglveks
1861	agdvdtlafd grtfveylna vtesekalqs nhfelslrte atqglvlwsg kateradyva
1921	laivdghlql synlgsqpvv lrstvpvntn rwlrvvahre qregslqvgn eapvtgsspl
1981	gatqldtdga lwlgglpelp vgpalpkayg tgfvgclrdv vvgrhplhll edavtkpelr
2041	pcptp
Gene ID:	X13
Gene symbol:	APP
Gene description:	Amyloid beta A4 protein
Unigene:	Hs.434980
Genbank:	BC065529|AF282245|AK298861|AK294534|AK295621|AK296229|AK297412|
	AK297229|AK295373|BC004369|M16765|AK311717
Entrez Gene:	351
Refseq:	NM_000484|NM_201413|NM_001136130|NM_201414|NM_001136129

Protein sequence isoform a (SEQ ID NO (21)):

1	mlpglallll aawtaralev ptdgnaglla epqiamfcgr lnmhmnvqng kwdsdpsgtk
61	tcidtkegil qycqevypel qitnvveanq pvtiqnwckr grkqckthph fvipyrclvg
121	efvsdallvp dkckflhqer mdvcethlhw htvaketcse kstnlhdygm llpcgidkfr
181	gvefvccpla eesdnvdsad aeeddsdvww ggadtdyadg sedkvvevae eeevaeveee
241	eadddedded gdeveeeaee pyeeatertt siattttttt esveevvrev cseqaetgpc
301	ramisrwyfd vtegkcapff yggcggnrnn fdteeycmav cgsamsqsll kttqeplard
361	pvklpttaas tpdavdkyle tpgdenehah fqkakerlea khrermsqvm reweeaerqa
421	knlpkadkka viqhfqekve sleqeaaner qqlvethmar veamlndrrr lalenyital
481	qavpprprhv fnmlkkyvra eqkdrqhtlk hfehvrmvdp kkaaqirsqv mthlrviyer
541	mnqslsllyn vpavaeeiqd evdellqkeq nysddvlanm iseprisygn dalmpsltet
601	kttvellpvn gefslddlqp whsfgadsvp antenevepv darpaadrgl ttrpgsgltn
661	ikteeisevk mdaefrhdsg yevhhqklvf faedvgsnkg aiiglmvggv viatvivitl
721	vmlkkkqyts ihhgvvevda avtpeerhls kmqqngyenp tykffeqmqn

Protein sequence isoform b (SEQ ID NO (22)):

1	mlpglallll aawtaralev ptdgnaglla epqiamfcgr lnmhmnvqng kwdsdpsgtk
61	tcidtkegil qycqevypel qitnvveanq pvtiqnwckr grkqckthph fvipyrclvg
121	efvsdallvp dkckflhqer mdvcethlhw htvaketcse kstnlhdygm llpcgidkfr
181	gvefvccpla eesdnvdsad aeeddsdvww ggadtdyadg sedkvvevae eeevaeveee
241	eadddedded gdeveeeaee pyeeatertt siattttttt esveevvrev cseqaetgpc
301	ramisrwyfd vtegkcapff yggcggnrnn fdteeycmav cgsaipttaa stpdavdkyl
361	etpgdeneha hfqkakerle akhrermsqv mreweeaerq aknlpkadkk aviqhfqekv
421	eslegeaane rqqlvethma rveamlndrr rlalenyita lqavpprprh vfnmlkkyvr
481	aeqkdrqhtl khfehvrmvd pkkaaqirsq vmthlrviye rmnqslslly nvpavaeeiq
541	devdellqke qnysddvlan miseprisyg ndalmpslte tkttvellpv ngefslddlq
601	pwhsfgadsv pantenevep vdarpaadrg lttrpgsglt nikteeisev kmdaefrhds
661	gyevhhqklv ffaedvgsnk gaiiglmvgg vviatvivit lvmlkkkqyt sihhgvvevd
721	aavtpeerhl skmqqngyen ptykffeqmq n

Protein sequence isoform f (SEQ ID NO (23)):

1	mlpglallll aawtaralev ypelqitnvv eanqpvtiqn wckrgrkqck thphfvipyr
61	clvgefvsda llvpdkckfl hqermdvcet hlhwhtvake tcsekstnlh dygmllpcgi
121	dkfrgvefvc cplaeesdnv dsadaeedds dvwwggadtd yadgsedkvv evaeeeevae
181	veeeeaddde ddedgdevee eaeepyeeat erttsiattt ttttesveev vrevcseqae
241	tgpcramisr wyfdvtegkc apffyggcgg nrnnfdteey cmavcgsams qsllkttqep
301	lardpvklpt taastpdavd kyletpgden ehahfqkake rleakhrerm sqvmreweea
361	erqaknlpka dkkaviqhfq ekvesleqea anerqqlvet hmarveamln drrrlaleny
421	italqavppr prhvfnmlkk yvraeqkdrq htlkhfehvr mvdpkkaaqi rsqvmthlrv
481	iyermnqsls llynvpavae eiqdevdell qkeqnysddv lanmisepri sygndalmps
541	ltetkttvel lpvngefsld dlqpwhsfga dsvpantene vepvdarpaa drglttrpgs
601	gltnikteei sevkmdaefr hdsgyevhhq klvffaedvg snkgaiiglm vggvviatvi
661	vitlvmlkkk qytsihhgvv evdaavtpee rhlskmqqng yenptykffe qmqn

Protein sequence isoform c (SEQ ID NO (24)):

1	mlpglallll aawtaralev ptdgnaglla epqiamfcgr lnmhmnvqng kwdsdpsgtk
61	tcidtkegil qycqevypel qitnvveanq pvtiqnwckr grkqckthph fvipyrclvg
121	efvsdallvp dkckflhqer mdvcethlhw htvaketcse kstnlhdygm llpcgidkfr
181	gvefvccpla eesdnvdsad aeeddsdvww ggadtdyadg sedkvvevae eeevaeveee
241	eadddedded gdeveeeaee pyeeatertt siattttttt esveevvrvp ttaastpdav
301	dkyletpgde nehahfqkak erleakhrer msqvmrewee aerqaknlpk adkkaviqhf
361	qekvesleqe aanerqqlve thmarveaml ndrrrlalen yitalqavpp rprhvfnmlk
421	kyvraeqkdr qhtlkhfehv rmvdpkkaaq irsqvmthlr viyermnqsl sllynvpava
481	eeiqdevdel lqkeqnysdd vlanmisepr isygndalmp sltetkttve llpvngefsl
541	ddlqpwhsfg adsvpanten evepvdarpa adrglttrpg sgltniktee isevkmdaef
601	rhdsgyevhh qklvffaedv gsnkgaiigl mvggvviatv ivitlvmlkk kqytsihhgv
661	vevdaavtpe erhlskmqqn gyenptykff eqmqn

Protein sequence isoform e (SEQ ID NO (25)):

1	mlpglallll aawtaralev ypelqitnvv eanqpvtiqn wckrgrkqck thphfvipyr
61	clvgefvsda llvpdkckfl hqermdvcet hlhwhtvake tcsekstnlh dygmllpcgi
121	dkfrgvefvc cplaeesdnv dsadaeedds dvwwggadtd yadgsedkvv evaeeeevae
181	veeeeaddde ddedgdevee eaeepyeeat erttsiattt ttttesveev vrvpttaast
241	pdavdkylet pgdenehahf qkakerleak hrermsqvmr eweeaerqak nlpkadkkav
301	iqhfqekves leqeaanerq qlvethmarv eamlndrrrl alenyitalq avpprprhvf
361	nmlkkyvrae qkdrqhtlkh fehvrmvdpk kaaqirsqvm thlrviyerm nqslsllynv
421	pavaeeiqde vdellqkeqn ysddvlanmi seprisygnd almpsltetk ttvellpvng
481	efslddlqpw hsfgadsvpa ntenevepvd arpaadrglt trpgsgltni kteeisevkm
541	daefrhdsgy evhhqklvff aedvgsnkga iiglmvggvv iatvivitlv mlkkkqytsi
601	hhgvvevdaa vtpeerhlsk mqqngyenpt ykffeqmqn
Gene ID:	X14
Gene symbol:	COLEC12
Gene description:	Collectin sub-family member 12
Unigene:	Hs.464422
Genbank:	AB038518
Entrez Gene:	81035
Refseq:	NM_130386

Protein sequence (SEQ ID NO (26)):

1	mkddfaeeee vqsfgykrfg iqegtqctkc knnwalkfsi illyilcall titvailgyk
61	vvekmdnvtg gmetsrqtyd dkltavesdl kklgdqtgkk aistnselst frsdildlrq
121	qlreitekts knkdtleklq asgdalvdrq sqlketlenn sflittvnkt lqayngyvtn
181	lqqdtsviqg nlqnqmyshn vvimnlnnln ltqvqqrnli tnlqrsvddt sqaiqriknd
241	fqnlqqvflq akkdtdwlke kvqslqtlaa nnsalakann dtledmnsql nsftgqmeni
301	ttisqaneqn lkdlqdlhkd aenrtaikfn qleerfqlfe tdivniisni sytahhlrtl
361	tsnlnevrtt ctdtltkhtd dltslnntla nirldsvslr mqqdlmrsrl dtevanlsvi
421	meemklvdsk hgqliknfti lqgppgprgp rgdrgsqgpp gptgnkgqkg ekgepgppgp
481	agergpigpa gppgerggkg skgsqgpkgs rgspgkpgpq gpsgdpgppg ppgkeglpgp
541	qgppgfqglq gtvgepgvpg prglpglpgv pgmpgpkgpp gppgpsgavv plalqneptp
601	apedngcpph wknftdkcyy fsvekeifed aklfcedkss hlvfintree qqwikkqmvg
661	reshwigltd serenewkwl dgtspdyknw kagqpdnwgh ghgpgedcag liyagqwndf
721	qcedvnnfic ekdretvlss al
Gene ID:	X15
Gene symbol:	NCAM1
Gene description:	Neural cell adhesion molecule 1
Unigene:	Hs.503878
Genbank:	BC047244
Entrez Gene:	4684
Refseq:	NM_000615|NM_001076682|NM_181351|NM_001242608|
	NM_001242607

Protein sequence isoform 1 (SEQ ID NO (27)):

1	mlqtkdliwt lfflgtavsl qvdivpsqge isvgeskffl cqvagdakdk diswfspnge
61	kltpnqqris vvwnddssst ltiynanidd agiykcvvtg edgseseatv nvkifqklmf
121	knaptpqefr egedavivcd vvsslpptii wkhkgrdvil kkdvrfivls nnylqirgik
181	ktdegtyrce grilargein fkdiqvivnv pptiqarqni vnatanlgqs vtlvcdaegf
241	peptmswtkd geqieqeedd ekyifsddss qltikkvdkn deaeyiciae nkageqdati
301	hlkvfakpki tyvenqtame leeqvtltce asgdpipsit wrtstrniss eektldghmv
361	vrsharvssl tlksiqytda geyictasnt igqdsqsmyl evqyapklqg pvavytwegn
421	qvnitcevfa ypsatiswfr dgqllpssny snikiyntps asylevtpds endfgnynct
481	avnrigqesl efilvqadtp sspsidqvep ysstaqvqfd epeatggvpi lkykaewrav
541	geevwhskwy dakeasmegi vtivglkpet tyavrlaaln gkglgeisaa sefktqpvqg
601	epsapklegq mgedgnsikv nlikqddggs pirhylvryr alssewkpei rlpsgsdhvm
661	lksldwnaey evyvvaenqq gkskaahfvf rtsaqptaip angsptsgls tgaivgiliv
721	ifvlllvvvd itcyflnkcg lfmciavnlc gkagpgakgk dmeegkaafs kdeskepive
781	vrteeertpn hdggkhtepn ettpltepek gpveakpecq etetkpapae vktvpndatq
841	tkeneska

Protein sequence isoform 3 (SEQ ID NO (28)):

1	mlqtkdliwt lfflgtavsl qvdivpsqge isvgeskffl cqvagdakdk diswfspnge
61	kltpnqqris vvwnddssst ltiynanidd agiykcvvtg edgseseatv nvkifqklmf
121	knaptpqefr egedavivcd vvsslpptii wkhkgrdvil kkdvrfivls nnylqirgik
181	ktdegtyrce grilargein fkdiqvivnv pptiqarqni vnatanlgqs vtlvcdaegf
241	peptmswtkd geqieqeedd ekyifsddss qltikkvdkn deaeyiciae nkageqdati
301	hlkvfakpki tyvenqtame leeqvtltce asgdpipsit wrtstrniss eektldghmv
361	vrsharvssl tlksiqytda geyictasnt igqdsqsmyl evqyapklqg pvavytwegn
421	qvnitcevfa ypsatiswfr dgqllpssny snikiyntps asylevtpds endfgnynct
481	avnrigqesl efilvqadtp sspsidqvep ysstaqvqfd epeatggvpi lkykaewrav
541	geevwhskwy dakeasmegi vtivglkpet tyavrlaaln gkglgeisaa sefktqpvhs
601	ppppasasss tpvplsppdt twplpalatt epakgepsap klegqmgedg nsikvnlikq
661	ddggspirhy lvryralsse wkpeirlpsg sdhvmlksld wnaeyevyvv aenqqgkska
721	ahfvfrtsaq ptaipatlgg nsasytfvsl lfsavtllll c

Protein sequence isoform 2 (SEQ ID NO (29)):

1	mlqtkdliwt lfflgtavsl qvdivpsqge isvgeskffl cqvagdakdk diswfspnge
61	kltpnqqris vvwnddssst ltiynanidd agiykcvvtg edgseseatv nvkifqklmf
121	knaptpqefr egedavivcd vvsslpptii wkhkgrdvil kkdvrfivls nnylqirgik
181	ktdegtyrce grilargein fkdiqvivnv pptiqarqni vnatanlgqs vtlvcdaegf
241	peptmswtkd geqieqeedd ekyifsddss qltikkvdkn deaeyiciae nkageqdati
301	hlkvfakpki tyvenqtame leeqvtltce asgdpipsit wrtstrniss eekaswtrpe
361	kqetldghmv vrsharvssl tlksiqytda geyictasnt igqdsqsmyl evqyapklqg
421	pvavytwegn qvnitcevfa ypsatiswfr dgqllpssny snikiyntps asylevtpds
481	endfgnynct avnrigqesl efilvqadtp sspsidqvep ysstaqvqfd epeatggvpi
541	lkykaewrav geevwhskwy dakeasmegi vtivglkpet tyavrlaaln gkglgeisaa
601	sefktqpvqg epsapklegq mgedgnsikv nlikqddggs pirhylvryr alssewkpei
661	rlpsgsdhvm lksldwnaey evyvvaenqq gkskaahfvf rtsaqptaip angsptsgls
721	tgaivgiliv ifvlllvvvd itcyflnkcg lfmciavnlc gkagpgakgk dmeegkaafs
781	kdeskepive vrteeertpn hdggkhtepn ettpltepek gpveakpecq etetkpapae
841	vktvpndatq tkeneska

Protein sequence isoform 4 (SEQ ID NO (30)):

1	mlqtkdliwt lfflgtavsl qvdivpsqge isvgeskffl cqvagdakdk diswfspnge
61	kltpnqqris vvwnddssst ltiynanidd agiykcvvtg edgseseatv nvkifqklmf
121	knaptpqefr egedavivcd vvsslpptii wkhkgrdvil kkdvrfivls nnylqirgik
181	ktdegtyrce grilargein fkdiqvivnv pptiqarqni vnatanlgqs vtlvcdaegf
241	peptmswtkd geqieqeedd ekyifsddss qltikkvdkn deaeyiciae nkageqdati
301	hlkvfakpki tyvenqtame leeqvtltce asgdpipsit wrtstrniss eektldghmv
361	vrsharvssl tlksiqytda geyictasnt igqdsqsmyl evqyapklqg pvavytwegn
421	qvnitcevfa ypsatiswfr dgqllpssny snikiyntps asylevtpds endfgnynct
481	avnrigqesl efilvqadtp sspsidqvep ysstaqvqfd epeatggvpi lkykaewrav
541	geevwhskwy dakeasmegi vtivglkpet tyavrlaaln gkglgeisaa sefktqpvqg
601	epsapklegq mgedgnsikv nlikqddggs pirhylvryr alssewkpei rlpsgsdhvm
661	lksldwnaey evyvvaenqq gkskaahfvf rtsaqptaip atlggnsasy tfvsllfsav
721	tllllc

Protein sequence isoform 5 (SEQ ID NO (31)):

1	mlqtkdliwt lfflgtavsl qvdivpsqge isvgeskffl cqvagdakdk diswfspnge
61	kltpnqqris vvwnddssst ltiynanidd agiykcvvtg edgseseatv nvkifqklmf
121	knaptpqefr egedavivcd vvsslpptii wkhkgrdvil kkdvrfivls nnylqirgik
181	ktdegtyrce grilargein fkdiqvivnv pptiqarqni vnatanlgqs vtlvcdaegf
241	peptmswtkd geqieqeedd ekyifsddss qltikkvdkn deaeyiciae nkageqdati
301	hlkvfakpki tyvenqtame leeqvtltce asgdpipsit wrtstrniss eekaswtrpe
361	kqevhapwnw qvgrqkgqag sagfpgshet ldghmvvrsh arvssltlks iqytdageyi
421	ctasntigqd sqsmylevqy apklqgpvav ytwegnqvni tcevfaypsa tiswfrdgql
481	lpssnysnik iyntpsasyl evtpdsendf gnynctavnr igqeslefil vqadtpssps
541	idqvepysst aqvqfdepea tggvpilkyk aewravgeev whskwydake asmegivtiv
601	glkpettyav rlaalngkgl geisaasefk tqpvqgepsa pklegqmged gnsikvnlik
661	qddggspirh ylvryralss ewkpeirlps gsdhvmlksl dwnaeyevyv vaenqqgksk
721	aahfvfrtsa qptaipangs ptsglstgai vgilivifvl llvvvditcy flnkcglfmc
781	iavnlcgkag pgakgkdmee gkaafskdes kepivevrte eertpnhdgg khtepnettp
841	ltepekgpve akpecqetet kpapaevktv pndatqtken eska
Gene ID:	X16
Gene symbol:	NRP2
Gene description:	Neuropilin-2
Unigene:	Hs.471200
Genbank:	BX537423|AF016098|BC101525|BC104770|BC117413|BC143238|BC143608|
	AF022860|AF280545|AF280544|AF022859|AK290934|AF280546|BC009222|
	AL833606|BX648292|AK130198|BC018631
Entrez Gene:	8828
Refseq:	NM_201266|NM_003872|NM_201279|NM_018534|NM_201267|NM_201264

Protein sequence isoform 1 (SEQ ID NO (32)):

1	mdmfpltwvf lalyfsrhqv rgqpdppcgg rlnskdagyi tspgypqdyp shqncewivy
61	apepnqkivl nfnphfeiek hdckydfiei rdgdsesadl lgkhcgniap ptiissgsml
121	yikftsdyar qgagfslrye ifktgsedcs knftspngti espgfpekyp hnldctftil
181	akpkmeiilq flifdlehdp lqvgegdcky dwldiwdgip hvgpligkyc gtktpselrs
241	stgilsltfh tdmavakdgf saryylvhqe plenfqcnvp lgmesgrian eqisasstys
301	dgrwtpqqsr lhgddngwtp nldsnkeylq vdlrfltmlt aiatqgaisr etqngyyvks
361	yklevstnge dwmvyrhgkn hkvfqannda tevvlnklha plltrfvrir pqtwhsgial
421	rlelfgcrvt dapcsnmlgm lsgliadsqi sasstqeylw spsaarlvss rsgwfpripq
481	aqpgeewlqv dlgtpktvkg viiqgarggd sitavearaf vrkfkvsysl ngkdweyiqd
541	prtqqpklfe gnmhydtpdi rrfdpipaqy vrvyperwsp agigmrlevl gcdwtdskpt
601	vetlgptvks eetttpypte eeatecgenc sfeddkdlql psgfncnfdf leepcgwmyd
661	hakwlrttwa sssspndrtf pddrnflrlq sdsqregqya rlisppvhlp rspvcmefqy
721	qatggrgval qvvreasqes kllwviredq ggewkhgrii lpsydmeyqi vfegvigkgr
781	sgeiaiddir istdvplenc mepisafage nfkvdipeih eregyedeid deyevdwsns
841	ssatsgsgap stdkekswly tldpilitii amsslgvllg atcaglllyc tcsysglssr
901	scttlenynf elydglkhkv kmnhqkccse a

Protein sequence isoform 2 (SEQ ID NO (33)):

1	mdmfpltwvf lalyfsrhqv rgqpdppcgg rlnskdagyi tspgypqdyp shqncewivy
61	apepnqkivl nfnphfeiek hdckydfiei rdgdsesadl lgkhcgniap ptiissgsml
121	yikftsdyar qgagfslrye ifktgsedcs knftspngti espgfpekyp hnldctftil
181	akpkmeiilq flifdlehdp lqvgegdcky dwldiwdgip hvgpligkyc gtktpselrs
241	stgilsltfh tdmavakdgf saryylvhqe plenfqcnvp lgmesgrian eqisasstys
301	dgrwtpqqsr lhgddngwtp nldsnkeylq vdlrfltmlt aiatqgaisr etqngyyvks
361	yklevstnge dwmvyrhgkn hkvfqannda tevvlnklha plltrfvrir pqtwhsgial
421	rlelfgcrvt dapcsnmlgm lsgliadsqi sasstqeylw spsaarlvss rsgwfpripq
481	aqpgeewlqv dlgtpktvkg viiqgarggd sitavearaf vrkfkvsysl ngkdweyiqd
541	prtqqpklfe gnmhydtpdi rrfdpipaqy vrvyperwsp agigmrlevl gcdwtdskpt
601	vetlgptvks eetttpypte eeatecgenc sfeddkdlql psgfncnfdf leepcgwmyd
661	hakwlrttwa sssspndrtf pddrnflrlq sdsqregqya rlisppvhlp rspvcmefqy
721	qatggrgval qvvreasqes kllwviredq ggewkhgrii lpsydmeyqi vfegvigkgr
781	sgeiaiddir istdvplenc mepisafavd ipeiheregy edeiddeyev dwsnsssats
841	gsgapstdke kswlytldpi litiiamssl gvllgatcag lllyctcsys glssrscttl
901	enynfelydg lkhkvkmnhq kccsea

Protein sequence isoform 3 (SEQ ID NO (34)):

1	mdmfpltwvf lalyfsrhqv rgqpdppcgg rlnskdagyi tspgypqdyp shqncewivy
61	apepnqkivl nfnphfeiek hdckydfiei rdgdsesadl lgkhcgniap ptiissgsml
121	yikftsdyar qgagfslrye ifktgsedcs knftspngti espgfpekyp hnldctftil
181	akpkmeiilq flifdlehdp lqvgegdcky dwldiwdgip hvgpligkyc gtktpselrs
241	stgilsltfh tdmavakdgf saryylvhqe plenfqcnvp lgmesgrian eqisasstys
301	dgrwtpqqsr lhgddngwtp nldsnkeylq vdlrfltmlt aiatqgaisr etqngyyvks
361	yklevstnge dwmvyrhgkn hkvfqannda tevvlnklha plltrfvrir pqtwhsgial
421	rlelfgcrvt dapcsnmlgm lsgliadsqi sasstqeylw spsaarlvss rsgwfpripq
481	aqpgeewlqv dlgtpktvkg viiqgarggd sitavearaf vrkfkvsysl ngkdweyiqd
541	prtqqpklfe gnmhydtpdi rrfdpipaqy vrvyperwsp agigmrlevl gcdwtdskpt
601	vetlgptvks eetttpypte eeatecgenc sfeddkdlql psgfncnfdf leepcgwmyd
661	hakwlrttwa sssspndrtf pddrnflrlq sdsqregqya rlisppvhlp rspvcmefqy
721	qatggrgval qvvreasqes kllwviredq ggewkhgrii lpsydmeyqi vfegvigkgr
781	sgeiaiddir istdvplenc mepisafade yevdwsnsss atsgsgapst dkekswlytl
841	dpilitiiam sslgvllgat caglllyctc sysglssrsc ttlenynfel ydglkhkvkm
901	nhqkccsea

Protein sequence isoform 4 (SEQ ID NO (35)):

1	mdmfpltwvf lalyfsrhqv rgqpdppcgg rlnskdagyi tspgypqdyp shqncewivy
61	apepnqkivl nfnphfeiek hdckydfiei rdgdsesadl lgkhcgniap ptiissgsml
121	yikftsdyar qgagfslrye ifktgsedcs knftspngti espgfpekyp hnldctftil
181	akpkmeiilq flifdlehdp lqvgegdcky dwldiwdgip hvgpligkyc gtktpselrs
241	stgilsltfh tdmavakdgf saryylvhqe plenfqcnvp lgmesgrian eqisasstys
301	dgrwtpqqsr lhgddngwtp nldsnkeylq vdlrfltmlt aiatqgaisr etqngyyvks
361	yklevstnge dwmvyrhgkn hkvfqannda tevvlnklha plltrfvrir pqtwhsgial
421	rlelfgcrvt dapcsnmlgm lsgliadsqi sasstqeylw spsaarlvss rsgwfpripq
481	aqpgeewlqv dlgtpktvkg viiqgarggd sitavearaf vrkfkvsysl ngkdweyiqd
541	prtqqpklfe gnmhydtpdi rrfdpipaqy vrvyperwsp agigmrlevl gcdwtdskpt
601	vetlgptvks eetttpypte eeatecgenc sfeddkdlql psgfncnfdf leepcgwmyd
661	hakwlrttwa sssspndrtf pddrnflrlq sdsqregqya rlisppvhlp rspvcmefqy
721	qatggrgval qvvreasqes kllwviredq ggewkhgrii lpsydmeyqi vfegvigkgr
781	sgeiaiddir istdvplenc mepisafage nfkggtllpg teptvdtvpm qpipaywyyv
841	maaggavlvl vsvalalvlh yhrfryaakk tdhsitykts hytngaplav eptltikleq
901	drgshc

Protein sequence isoform 5 (SEQ ID NO (36)):

1	mdmfpltwvf lalyfsrhqv rgqpdppcgg rlnskdagyi tspgypqdyp shqncewivy
61	apepnqkivl nfnphfeiek hdckydfiei rdgdsesadl lgkhcgniap ptiissgsml
121	yikftsdyar qgagfslrye ifktgsedcs knftspngti espgfpekyp hnldctftil
181	akpkmeiilq flifdlehdp lqvgegdcky dwldiwdgip hvgpligkyc gtktpselrs
241	stgilsltfh tdmavakdgf saryylvhqe plenfqcnvp lgmesgrian eqisasstys
301	dgrwtpqqsr lhgddngwtp nldsnkeylq vdlrfltmlt aiatqgaisr etqngyyvks
361	yklevstnge dwmvyrhgkn hkvfqannda tevvlnklha plltrfvrir pqtwhsgial
421	rlelfgcrvt dapcsnmlgm lsgliadsqi sasstqeylw spsaarlvss rsgwfpripq
481	aqpgeewlqv dlgtpktvkg viiqgarggd sitavearaf vrkfkvsysl ngkdweyiqd
541	prtqqpklfe gnmhydtpdi rrfdpipaqy vrvyperwsp agigmrlevl gcdwtdskpt
601	vetlgptvks eetttpypte eeatecgenc sfeddkdlql psgfncnfdf leepcgwmyd
661	hakwlrttwa sssspndrtf pddrnflrlq sdsqregqya rlisppvhlp rspvcmefqy
721	qatggrgval qvvreasqes kllwviredq ggewkhgrii lpsydmeyqi vfegvigkgr
781	sgeiaiddir istdvplenc mepisafagg tllpgteptv dtvpmqpipa ywyyvmaagg
841	avlvlvsval alvlhyhrfr yaakktdhsi tyktshytng aplaveptlt ikleqdrgsh
901	c

Protein sequence isoform 6 (SEQ ID NO (37)):

1	mdmfpltwvf lalyfsrhqv rgqpdppcgg rlnskdagyi tspgypqdyp shqncewivy
61	apepnqkivl nfnphfeiek hdckydfiei rdgdsesadl lgkhcgniap ptiissgsml
121	yikftsdyar qgagfslrye ifktgsedcs knftspngti espgfpekyp hnldctftil
181	akpkmeiilq flifdlehdp lqvgegdcky dwldiwdgip hvgpligkyc gtktpselrs
241	stgilsltfh tdmavakdgf saryylvhqe plenfqcnvp lgmesgrian eqisasstys
301	dgrwtpqqsr lhgddngwtp nldsnkeylq vdlrfltmlt aiatqgaisr etqngyyvks
361	yklevstnge dwmvyrhgkn hkvfqannda tevvlnklha plltrfvrir pqtwhsgial
421	rlelfgcrvt dapcsnmlgm lsgliadsqi sasstqeylw spsaarlvss rsgwfpripq
481	aqpgeewlqv dlgtpktvkg viiqgarggd sitavearaf vrkfkvsysl ngkdweyiqd
541	prtqqpkvgc swrpl
Gene ID:	X17
Gene symbol:	PLXNA2
Gene description:	Plexin-A2
Unigene:	Hs.497626
Genbank:	BC132676
Entrez Gene:	5362
Refseq:	NM_025179

Protein sequence (SEQ ID NO (38)):

1	meqrrpwpra levdsrsvvl lsvvwvllap paagmpqfst fhsenrdwtf nhltvhqgtg
61	avyvgainrv ykltgnltiq vahktgpeed nkscyppliv qpcsevltlt nnvnklliid
121	ysenrllacg slyqgvckll rlddlfilve pshkkehyls svnktgtmyg vivrsegedg
181	klfigtavdg kqdyfptlss rklprdpess amldyelhsd fvsslikips dtlalvshfd
241	ifyiygfasg gfvyfltvqp etpegvains agdlfytsri vrlckddpkf hsyvslpfgc
301	tragveyrll qaaylakpgd slaqafnits qddvlfaifs kgqkqyhhpp ddsalcafpi
361	rainlqiker lqscyqgegn lelnwllgkd vqctkapvpi ddnfcgldin qplggstpve
421	gltlyttsrd rmtsvasyvy ngysvvfvgt ksgklkkira dgpphggvqy emvsvlkdgs
481	pilrdmafsi dqrylyvmse rqvtrvpves ceqyttcgec lssgdphcgw calhnmcsrr
541	dkcqqawepn rfaasisqcv slavhpssis vsehsrllsl vvsdapdlsa giacafgnlt
601	evegqvsgsq vicispgpkd vpvipldqdw fglelqlrsk etgkifvste fkfyncsahq
661	lclscvnsaf rchwckyrnl cthdpttcsf qegrinised cpqlvpteei lipvgevkpi
721	tlkarnlpqp qsgqrgyecv lniqgaihrv palrfnsssv qcqnssyqyd gmdisnlavd
781	favvwngnfi idnpqdlkvh lykcaaqres cglclkadrk fecgwcsger rctlhqhcts
841	psspwldwss hnvkcsnpqi teiltvsgpp eggtrvtihg vnlgldfsei ahhvqvagvp
901	ctplpgeyii aeqivcemgh alvgttsgpv rlcigeckpe fmtkshqqyt fvnpsvlsln
961	pirgpesggt mvtitghylg agssvavylg nqtcefygrs mseivcvspp ssnglgpvpv
1021	svsvdrahvd snlqfeyidd prvqriepew siasghtplt itgfnldviq eprirvkfng
1081	kesvnvckvv ntttltclap slttdyrpgl dtverpdefg fvfnnvqsll iyndtkfiyy
1141	pnptfellsp tgvldqkpgs piilkgknlc ppasggakln ytvligetpc avtvsetqll
1201	ceppnltgqh kvmvhvggmv fspgsvsvis dslltlpaiv siaaggslll iiviivliay
1261	krksrendlt lkrlqmqmdn lesrvaleck eafaelqtdi neltsdldrs gipyldyrty
1321	amrvlfpgie dhpvlrelev qgngqqhvek alklfaqlin nkvflltfir tlelqrsfsm
1381	rdrgnvasli mtglqgrley atdvlkqlls dlidknlenk nhpklllrrt esvaekmltn
1441	wfafllhkfl kecageplfm lycaikqqme kgpidaitge aryslsedkl irqqieyktl
1501	ilncvnpdne nspeipvkvl ncdtitqvke kildavyknv pysqrpravd mdlewrqgri
1561	arvvlqdedi ttkiegdwkr lntlmhyqvs drswvalvpk qtssynipas asisrtsisr
1621	ydssfrytgs pdslrsrapm itpdlesgvk vwhlvknhdh gdqkegdrgs kmvseiyltr
1681	llatkgtlqk fvddlfetlf stvhrgsalp laikymfdfl deqadrhsih dtdvrhtwks
1741	nclplrfwvn viknpqfvfd ihkgsitdac lsvvaqtfmd scstsehrlg kdspsnklly
1801	akdipsyksw veryyadiak lpaisdqdmn aylaeqsrlh avefnmlsal neiysyvsky
1861	seeligaleq deqarrqrla ykveqlinam sies
Gene ID:	X18
Gene symbol:	PCDHA4
Gene description:	Protocadherin alpha-4
Unigene:	Hs.199343
Genbank:	AF152482|AF152312
Entrez Gene:	56144
Refseq:	NM_018907|NM_031500

Protein sequence isoform 1 (SEQ ID NO (39)):

1	mefswgsgqe srrlllllll laaweagngq lhysvseeak hgtfvgriaq dlglelaelv
61	prlfrvaskg rggllevnlq ngilfvnsri dreelcrrsa ecsihleviv drplqvfhvd
121	vevrdindnp pvfpatqknl siaesrplds rfplegasda digenallty rlspneyfsl
181	ekppddelvk glglilrksl dreeapeifl vltatdggkp eltgtvqlli tvldandnap
241	afdrtiykvr llenvpngtl viklnasdld eglngdivys fsndispnvk skfhidpitg
301	qiivkgyidf eesksyeiiv egidkgqlpl sghcrvivev ednndnvpdl efkslslpir
361	edaplgtvia lisvsdkdmg vnglvtcslt shvpfklvst fknyyslvld saldresvsa
421	yelvvtardg gspslwatas vsvevadvnd napafaqpey tvfvkennpp gchiftvsaw
481	dadaqenalv syslverrvg eralssyvsv haesgkvyal qpldheelel lqfqvtarda
541	gvpplgsnvt lqvfvldend napallapra ggtggavsel vpwsvgvghv vakvravdad
601	sgynawlsye lqpgtggari pfrvglytge isttraldet daprhrllvl vkdhgepalt
661	atatvlvslv esgqapkass ralvgavgpd aalvdvnvyl iiaicavssl lvltlllyta
721	lrcsalpteg acapgkptlv cssavgswsy sqqrrprvcs gegppktdlm afspslpdsr
781	dredqlqtte esfakprqpn pdwrysaslr agmhssvhle eagilragpg gpdqqwptvs
841	satpepeage vsppvgagvn snswtfkygp gnpkqsgpge lpdkfiipgs paiisirqep
901	tnsqidksdf itfgkkeetk kkkkkkkgnk tqekkekgns ttdnsdq

Protein sequence isoform 2 (SEQ ID NO (40)):

1	mefswgsgqe srrlllllll laaweagngq lhysvseeak hgtfvgriaq dlglelaelv
61	prlfrvaskg rggllevnlq ngilfvnsri dreelcrrsa ecsihleviv drplqvfhvd
121	vevrdindnp pvfpatqknl siaesrplds rfplegasda digenallty rlspneyfsl
181	ekppddelvk glglilrksl dreeapeifl vltatdggkp eltgtvqlli tvldandnap
241	afdrtiykvr llenvpngtl viklnasdld eglngdivys fsndispnvk skfhidpitg
301	qiivkgyidf eesksyeiiv egidkgqlpl sghcrvivev ednndnvpdl efkslslpir
361	edaplgtvia lisvsdkdmg vnglvtcslt shvpfklvst fknyyslvld saldresvsa
421	yelvvtardg gspslwatas vsvevadvnd napafaqpey tvfvkennpp gchiftvsaw
481	dadaqenalv syslverrvg eralssyvsv haesgkvyal qpldheelel lqfqvtarda
541	gvpplgsnvt lqvfvldend napallapra ggtggavsel vpwsvgvghv vakvravdad
601	sgynawlsye lqpgtggari pfrvglytge isttraldet daprhrllvl vkdhgepalt
661	atatvlvslv esgqapkass ralvgavgpd aalvdvnvyl iiaicavssl lvltlllyta
721	lrcsalpteg acapgkptlv cssavgswsy sqqrrprvcs gegppktdlm afspslpdsr
781	dredqlqtte esfakvsv
Gene ID:	X19
Gene symbol:	PCDHAC2
Gene description:	Protocadherin alpha-C2
Unigene:	Hs.199343
Genbank:	AF152304
Entrez Gene:	56134
Refseq:	NM_018899|NM_031883

Protein sequence isoform 1 (SEQ ID NO (41)):

1	meqagtrpaa tehprlrrpm pwllllplll llllllpgpa asqlrysvpe eqapgalvgn
61	varalglelr rlgpgclrin hlgapspryl eldltsgalf vneridreal ceqrprclls
121	levlahnpva vsaveveild indnsprfpr pnyqlqvses vapgarfhie saqdpdvgan
181	svqtyelsps ehfeldlkpl qenskvlelv lrkgldreqa alhhlvltav dggiparsgt
241	aqisvrvldt ndnspafdqs tyrvqlreds ppgtlvvkln asdpdegsng elryslssyt
301	sdrerqlfsi dastgevrvi ggldyeeass yqiyvqatdr gpvpmaghck vlvdivdvnd
361	napevvltdl yspvpenatp ntivavlsvn dqdsgpnrkv slgleatlpf rlngfgnsyt
421	lvvsgpldre rvavynitvt atdggipqlt slrtlkveis dindnppsfl edsysiyiqe
481	nnlpgvllct vqatdpdeke naevtyslle reiqglpvts yvsinsasgs lyavnsfdye
541	kfreffvtve aqdkgsppls stvtanvyvv dmndhaphil yptstnssaa femvprtapa
601	gylvtkviam dsdsgqnawl fyhlaqtsdl dlfkvelhtg eirttrkmgd esgstfnltv
661	vvrdngepsl sasvaitvav vdrvskilpd tqrhvksprt yseitlylii alstvsfifl
721	ltiiilsiik cyrytaygta ccggfcgvre rspaelykqa nnnidariph glkvqphfie
781	vrgngsltkt ycykacltag sgsdtfmfyn tgaqtgpgps gaqaavtdsr nltgqsgqna
841	gnliilknea vsqneprqpn pdwrysaslr agmhssvhle eagilragpg gpdqqwptvs
901	satpepeage vsppvgagvn snswtfkygp gnpkqsgpge lpdkfiipgs paiisirqep
961	tnsqidksdf itfgkkeetk kkkkkkkgnk tqekkekgns ttdnsdq

Protein sequence isoform 2 (SEQ ID NO (42)):

1	meqagtrpaa tehprlrrpm pwllllplll llllllpgpa asqlrysvpe eqapgalvgn
61	varalglelr rlgpgclrin hlgapspryl eldltsgalf vneridreal ceqrprclls
121	levlahnpva vsaveveild indnsprfpr pnyqlqvses vapgarfhie saqdpdvgan
181	svqtyelsps ehfeldlkpl qenskvlelv lrkgldreqa alhhlvltav dggiparsgt
241	aqisvrvldt ndnspafdqs tyrvqlreds ppgtlvvkln asdpdegsng elryslssyt
301	sdrerqlfsi dastgevrvi ggldyeeass yqiyvqatdr gpvpmaghck vlvdivdvnd
361	napevvltdl yspvpenatp ntivavlsvn dqdsgpnrkv slgleatlpf rlngfgnsyt
421	lvvsgpldre rvavynitvt atdggipqlt slrtlkveis dindnppsfl edsysiyiqe
481	nnlpgvllct vqatdpdeke naevtyslle reiqglpvts yvsinsasgs lyavnsfdye
541	kfreffvtve aqdkgsppls stvtanvyvv dmndhaphil yptstnssaa femvprtapa
601	gylvtkviam dsdsgqnawl fyhlaqtsdl dlfkvelhtg eirttrkmgd esgstfnltv
661	vvrdngepsl sasvaitvav vdrvskilpd tqrhvksprt yseitlylii alstvsfifl
721	ltiiilsiik cyrytaygta ccggfcgvre rspaelykqa nnnidariph glkvqphfie
781	vrgngsltkt ycykacltag sgsdtfmfyn tgaqtgpgps gaqaavtdsr nltgqsgqna
841	gnliilknea vsqnevrqws ggllqthafv thppiscdla llsh
Gene ID:	X20
Gene symbol:	GPC4
Gene description:	Glypican 4
Unigene:	Hs.58367
Genbank:	AF030186
Entrez Gene:	2239
Refseq:	NM_001448

Protein sequence (SEQ ID NO (43)):

1	mrllwklvil lplinssagd gllsrpiftq ephdvifpld lsksevilnc aangypsphy
61	rwkqngtdid ftmsyhyrld ggslainsph tdqdigmyqc latnllgtil srkaklqfay
121	iedfetktrs tvsvregqgv vllcgppphf gdlsyawtfn dnplyvqedn rrfvsqetgn
181	lyiakvepsd vgnytcfitn keaqrsvqgp ptplvqrtdg vmgeyepkie vrfpetiqaa
241	kdssvklecf algnpvpdis wrrldgsplp gkvkysksqa ileipnfqqe degfyecias
301	nlrgrnlakg qlifyappew eqkiqnthls iydnllweck asgkpnpwyt wlkngerlnp
361	eeriqiengt liitmlnvsd sgvyqcaaen kyqiiyanae lrvlasapdf skspvkkksf
421	vqvggdivig ckpnafpraa iswkrgtetl rqskriflle dgslkiynit rsdagsytci
481	atnqfgtakn tgslivkert vitvppskmd vtvgesivlp cqvshdpsie vvfvwffngd
541	vidlkkgvah feriggesvg dlmirniqlh hsgkylctvq ttleslsava diivrgppgp
601	pedvqvedis sttsqlswra gpdnnspiqi ftiqtrtpfs vgwqavatvp eilngktyna
661	tvvglspwve yefrvvagns igigepseps ellrtkasvp vvapvnihgg ggsrselvit
721	wesipeelqn gegfgyiimf rpvgsttwsk ekvssvessr fvyrnesiip lspfevkvgv
781	ynnegegsls tvtivysged epqlaprgts lqsfsaseme vswnaiawnr ntgrvlgyev
841	lywtddskes migkirvsgn vttknitglk antiyfasvr ayntagtgps sppvnvttkk
901	sppsqppani awkltnsklc lnwehvktme nesevlgyki lyrqnrqskt hiletnntsa
961	ellvpfeedy lieirtvsdg gdgssseeir ipkmsslssr giqflepsth flsivivifh
1021	cfaiqpli
Gene ID:	X21
Gene symbol:	CNTN6
Gene description:	Contactin 6
Unigene:	Hs.387300
Genbank:	AB003592
Entrez Gene:	27255
Refseq:	NM_014461

Protein sequence (SEQ ID NO (44)):

1	marfglpall ctlavlsaal laaelksksc sevrrlyvsk gfnkndaplh eingdhlkic
61	pqgstccsqe meekyslqsk ddfksvvseq cnhlqavfas rykkfdeffk ellenaeksl
121	ndmfvktygh lymqnselfk dlfvelkryy vvgnvnleem lndfwarlle rmfrivnsqy
181	hftdeylecv skyteqlkpf gdvprklklq vtrafvaart faqglavagd vvskvsvvnp
241	taqcthallk miycshcrgl vtvkpcynyc snimrgclan qgdldfewnn fidamlmvae
301	rlegpfnies vmdpidvkis daimnmqdns vqvsqkvfqg cgppkplpag risrsisesa
361	fsarfrphhp eerpttaagt sldrlvtdvk eklkqakkfw sslpsnvcnd ermaagngne
421	ddcwngkgks rylfavtgng lanqgnnpev qvdtskpdil ilrqimalrv mtskmknayn
481	gndvdffdis dessgegsgs gceyqqcpse fdynatdhag ksanekadsa gvrpgaqayl
541	ltvfcilflv mqrewr
Gene ID:	X22
Gene symbol:	SLC9A7
Gene description:	solute carrier family 9 (sodium/hydrogen exchanger), member 7
Unigene:	Hs.496057
Genbank:	AF298591
Entrez Gene:	84679
Refseq:	NM_001257291|NM_032591

Protein sequence isoform 1 (SEQ ID NO (45)):

1	mepgdaarpg sgratgappp rllllplllg wglrvaaaas asssgaaaed ssameelate
61	keaeeshrqd svslltfill ltltiltiwl fkhrrvrflh etglamiygl ivgvilrygt
121	patsgrdksl sctqedrafs tllvnvsgkf feytlkgeis pgkinsveqn dmlrkvtfdp
181	evffnillpp iifhagyslk krhffrnlgs ilayaflgta vscfiignlm ygvvklmkim
241	gqlsdkfyyt dclffgaiis atdpvtvlai fnelhadvdl yallfgesvl ndavaivlss
301	sivayqpagl nthafdaaaf fksvgiflgi fsgsftmgav tgvvtalvtk ftklhcfpll
361	etalfflmsw stfllaeacg ftgvvavlfc gitqahytyn nlsvesrsrt kqlfevlhfl
421	aenfifsymg lalftfqkhv fspifiigaf vaiflgraah iyplsfflnl grrhkigwnf
481	qhmmmfsglr gamafalair dtasyarqmm ftttllivff tvwiigggtt pmlswlnirv
541	gveepseedq nehhwqyfrv gvdpdqdppp nndsfqvlqg dgpdsargnr tkqesawifr
601	lwysfdhnyl kpilthsgpp ltttlpawcg llarcltspq vydnqeplre edsdfilteg
661	dltltygdst vtangssssh tastslegsr rtkssseevl erdlgmgdqk vssrgtrlvf
721	pledna

Protein sequence isoform 2 (SEQ ID NO (46)):

1	mepgdaarpg sgratgappp rllllplllg wglrvaaaas asssgaaaed ssameelate
61	keaeeshrqd svslltfill ltltiltiwl fkhrrvrflh etglamiygl ivgvilrygt
121	patsgrdksl sctqedrafs tllvnvsgkf feytlkgeis pgkinsveqn dmlrkvtfdp
181	evffnillpp iifhagyslk krhffrnlgs ilayaflgta vscfiignlm ygvvklmkim
241	gqlsdkfyyt dclffgaiis atdpvtvlai fnelhadvdl yallfgesvl ndavaivlss
301	sivayqpagl nthafdaaaf fksvgiflgi fsgsftmgav tgvnanvtkf tklhcfplle
361	talfflmsws tfllaeacgf tgvvavlfcg itqahytynn lsvesrsrtk qlfevlhfla
421	enfifsymgl alftfqkhvf spifiigafv aiflgraahi yplsfflnlg rrhkigwnfq
481	hmmmfsglrg amafalaird tasyarqmmf tttllivfft vwiigggttp mlswlnirvg
541	veepseedqn ehhwqyfrvg vdpdqdpppn ndsfqvlqgd gpdsargnrt kqesawifrl
601	wysfdhnylk pilthsgppl tttlpawcgl larcltspqv ydnqeplree dsdfiltegd
661	ltltygdstv tangssssht astslegsrr tkssseevle rdlgmgdqkv ssrgtrlvfp
721	ledna
Gene ID:	X23
Gene symbol:	PVRL3
Gene description:	poliovirus receptor-related 3
Unigene:	Hs.293917
Genbank:	AK075105
Entrez Gene:	25945
Refseq:	NM_015480|NM_001243286|NM_001243288

Protein sequence isoform 1 (SEQ ID NO (47)):

1	martlrpspl cpgggkaqls sasllgagll lqpptpppll lllfplllfs rlcgalagpi
61	ivephvtavw gknvslkcli evnetitqis wekihgkssq tvavhhpqyg fsvqgeyqgr
121	vlfknyslnd atitlhnigf sdsgkyicka vtfplgnaqs sttvtvlvep tvslikgpds
181	lidggnetva aiciaatgkp vahidwegdl gemestttsf pnetatiisq yklfptrfar
241	grritcvvkh palekdirys fildiqyape vsvtgydgnw fvgrkgvnlk cnadanpppf
301	ksvwsrldgq wpdgllasdn tlhfvhpltf nysgvyickv tnslgqrsdq kviyisdppt
361	tttlqptiqw hpstadiedl atepkklpfp lstlatikdd tiatiiasvv ggalfivlvs
421	vlagifcyrr rrtfrgdyfa knyippsdmq kesqidvlqq deldsypdsv kkenknpvnn
481	lirkdyleep ektqwnnven lnrferpmdy yedlkmgmkf vsdehydene ddlvshvdgs
541	visrrewyv

Protein sequence isoform 2 (SEQ ID NO (48)):

1	martlrpspl cpgggkaqls sasllgagll lqpptpppll lllfplllfs rlcgalagpi
61	ivephvtavw gknvslkcli evnetitqis wekihgkssq tvavhhpqyg fsvqgeyqgr
121	vlfknyslnd atitlhnigf sdsgkyicka vtfplgnaqs sttvtvlvep tvslikgpds
181	lidggnetva aiciaatgkp vahidwegdl gemestttsf pnetatiisq yklfptrfar
241	grritcvvkh palekdirys fildiqyape vsvtgydgnw fvgrkgvnlk cnadanpppf
301	ksvwsrldgq wpdgllasdn tlhfvhpltf nysgvyickv tnslgqrsdq kviyisayns
361	vaslnc

Protein sequence isoform 3 (SEQ ID NO (49)):

1	maegwrwcfv rrtpgllrgp llprsfsgnp ralagpiive phvtavwgkn vslkclievn
61	etitqiswek ihgkssqtva vhhpqygfsv qgeyqgrvlf knyslndati tlhnigfsds
121	gkyickavtf plgnaqsstt vtvlveptvs likgpdslid ggnetvaaic iaatgkpvah
181	idwegdlgem estttsfpne tatiisqykl fptrfargrr itcvvkhpal ekdirysfil
241	diqyapevsv tgydgnwfvg rkgvnlkcna danpppfksv wsrldgqwpd gllasdntlh
301	fvhpltfnys gvyickvtns lgqrsdqkvi yisdvpfkqt ssiavagavi gavlalfiia
361	ifvtvlltpr kkrpsyldkv idlppthkpp plyeersppl pqkdlfqpeh lplqtqfker
421	evgnlqhsng lnsrsfdyed enpvgedgiq qmyplynqmc yqdrspgkhh qnndpkrvyi
481	dprehyv
Gene ID:	X24
Gene symbol:	SLC4A4
Gene description:	solute carrier family 4, sodium bicarbonate cotransporter, member 4
Unigene:	Hs.5462
Genbank:	AF011390
Entrez Gene:	8671
Refseq:	NM_001098484|NM_001134742|NM_003759

Protein sequence isoform 1 (SEQ ID NO (50)):

1	medeavldrg asflkhvcde eeveghhtiy igvhvpksyr rrrrhkrktg hkekkekeri
61	senysdksdi enadessssi lkplispaae rirfilgeed dspappqlft eldellavdg
121	qemewketar wikfeekveq ggerwskphv atlslhslfe lrtcmekgsi mldreasslp
181	qlvemivdhq ietgllkpel kdkvtytllr khrhqtkksn lrsladigkt vssasrmftn
241	pdngspamth rnltssslnd isdkpekdql knkfmkklpr daeasnvlvg evdfldtpfi
301	afvrlqqavm lgaltevpvp trflfillgp kgkaksyhei graiatlmsd evfhdiayka
361	kdrhdliagi defldevivl ppgewdpair ieppkslpss dkrknmysgg envqmngdtp
421	hdgghggggh gdceelqrtg rfcgglikdi krkapffasd fydalniqal sailfiylat
481	vtnaitfggl lgdatdnmqg vlesflgtav sgaifclfag qpltilsstg pvlvferllf
541	nfskdnnfdy lefrlwiglw saflclilva tdasflvqyf trfteegfss lisfifiyda
601	fkkmiklady ypinsnfkvg yntlfsctcv ppdpanisis ndttlapeyl ptmsstdmyh
661	nttfdwafls kkecskyggn lvgnncnfvp ditlmsfilf lgtytssmal kkfktspyfp
721	ttarklisdf aiilsilifc vidalvgvdt pklivpsefk ptspnrgwfv ppfgenpwwv
781	claaaipall vtilifmdqq itavivnrke hklkkgagyh ldlfwvailm vicslmalpw
841	yvaatvisia hidslkmete tsapgeqpkf lgvreqrvtg tlvfiltgls vfmapilkfi
901	pmpvlygvfl ymgvasingv qfmdrlklll mplkhqpdfi ylrhvplrrv hlftflqvlc
961	lallwilkst vaaiifpvmi lalvavrkgm dylfsqhdls flddvipekd kkkkedekkk
1021	kkkkgsldsd nddsdcpyse kvpsikipmd imeqqpflsd skpsdrersp tflerhtsc

Protein sequence isoform 3 (SEQ ID NO (51)):

1	medeavldrg asflkhvcde eeveghhtiy igvhvpksyr rrrrhkrktg hkekkekeri
61	senysdksdi enadessssi lkplispaae rirfilgeed dspappqlft eldellavdg
121	qemewketar wikfeekveq ggerwskphv atlslhslfe lrtcmekgsi mldreasslp
181	qlvemivdhq ietgllkpel kdkvtytllr khrhqtkksn lrsladigkt vssasrmftn
241	pdngspamth rnltssslnd isdkpekdql knkfmkklpr daeasnvlvg evdfldtpfi
301	afvrlqqavm lgaltevpvp trflfillgp kgkaksyhei graiatlmsd evfhdiayka
361	kdrhdliagi defldevivl ppgewdpair ieppkslpss dkrknmysgg envqmngdtp
421	hdgghggggh gdceelqrtg rfcgglikdi krkapffasd fydalniqal sailfiylat
481	vtnaitfggl lgdatdnmqg vlesflgtav sgaifclfag qpltilsstg pvlvferllf
541	nfskdnnfdy lefrlwiglw saflclilva tdasflvqyf trfteegfss lisfifiyda
601	fkkmiklady ypinsnfkvg yntlfsctcv ppdpanisis ndttlapeyl ptmsstdmyh
661	nttfdwafls kkecskyggn lvgnncnfvp ditlmsfilf lgtytssmal kkfktspyfp
721	ttarklisdf aiilsilifc vidalvgvdt pklivpsefk ptspnrgwfv ppfgenpwwv
781	claaaipall vtilifmdqq itavivnrke hklkkgagyh ldlfwvailm vicslmalpw
841	yvaatvisia hidslkmete tsapgeqpkf lgvreqrvtg tlvfiltgls vfmapilkfi
901	pmpvlygvfl ymgvaslngv qfmdrlklll mplkhqpdfi ylrhvplrrv hlftflqvlc
961	lallwilkst vaaiifpvmi lalvavrkgm dylfsqhdls flddvipekd kkkkedekkk
1021	kkkkgsldsd nddekdhqhs lnathhadki pflqslgmps pprtpvkvvp qirieleped
1081	ndyfwrskgt ettl

Protein sequence isoform 2 (SEQ ID NO (52)):

1	mstenvegkp snlgergrar sstflrvvqp mfnhsiftsa vspaaerirf ilgeeddspa
61	ppqlftelde llavdgqeme wketarwikf eekveqgger wskphvatls lhslfelrtc
121	mekgsimldr easslpqlve mivdhqietg llkpelkdkv tytllrkhrh qtkksnlrsl
181	adigktvssa srmftnpdng spamthrnlt ssslndisdk pekdqlknkf mkklprdaea
241	snvlvgevdf ldtpfiafvr lqqavmlgal tevpvptrfl fillgpkgka ksyheigrai
301	atlmsdevfh diaykakdrh dliagidefl devivlppge wdpairiepp kslpssdkrk
361	nmysggenvq mngdtphdgg hgggghgdce elqrtgrfcg glikdikrka pffasdfyda
421	lniqalsail fiylatvtna itfggllgda tdnmqgvles flgtavsgai fclfagqplt
481	ilsstgpvlv ferllfnfsk dnnfdylefr lwiglwsafl clilvatdas flvqyftrft
541	eegfsslisf ifiydafkkm ikladyypin snfkvgyntl fsctcvppdp anisisndtt
601	lapeylptms stdmyhnttf dwaflskkec skyggnlvgn ncnfvpditl msfilflgty
661	tssmalkkfk tspyfpttar klisdfaiil silifcvida lvgvdtpkli vpsefkptsp
721	nrgwfvppfg enpwwvclaa aipallvtil ifmdqqitav ivnrkehklk kgagyhldlf
781	wvailmvics lmalpwyvaa tvisiahids lkmetetsap geqpkflgvr eqrvtgtlvf
841	iltglsvfma pilkfipmpv lygvflymgv aslngvqfmd rlklllmplk hqpdfiylrh
901	vplrrvhlft flqvlclall wilkstvaai ifpvmilalv avrkgmdylf sqhdlsfldd
961	vipekdkkkk edekkkkkkk gsldsdndds dcpysekvps ikipmdimeq qpflsdskps
1021	drersptfle rhtsc
Gene ID:	X25
Gene symbol:	CXADR
Gene description:	coxsackie virus and adenovirus receptor
Unigene:	Hs.634837
Genbank:	AY072912|AY072911|AY072910|AK313526|
Entrez Gene:	1525
Refseq:	NM_001338|NM_001207063|NM_001207064|NM_001207065|
	NM_001207066

Protein sequence isoform 1 (SEQ ID NO (53)):

1	malllcfvll cgvvdfarsl sittpeemie kakgetaylp ckftlspedq gpldiewlis
61	padnqkvdqv iilysgdkiy ddyypdlkgr vhftsndlks gdasinvtnl qlsdigtyqc
121	kvkkapgvan kkihlvvlvk psgarcyvdg seeigsdfki kcepkegslp lqyewqklsd
181	sqkmptswla emtssvisvk nasseysgty sctvrnrvgs dqcllrlnvv ppsnkaglia
241	gaiigtllal aligliifcc rkkrreekye kevhhdired vpppksrtst arsyigsnhs
301	slgsmspsnm egysktqynq vpsedfertp qsptlppakv aapnlsrmga ipvmipaqsk
361	dgsiv

Protein sequence isoform 2 (SEQ ID NO (54)):

1	malllcfvll cgvvdfarsl sittpeemie kakgetaylp ckftlspedq gpldiewlis
61	padnqkvdqv iilysgdkiy ddyypdlkgr vhftsndlks gdasinvtnl qlsdigtyqc
121	kvkkapgvan kkihlvvlvk psgarcyvdg seeigsdfki kcepkegslp lqyewqklsd
181	sqkmptswla gkmchlqrav rplpeatsav iihpwgpcll ptwkdiprls itkyqvktln
241	allrvrlshl lr

Protein sequence isoform 3 (SEQ ID NO (55)):

1	malllcfvll cgvvdfarsl sittpeemie kakgetaylp ckftlspedq gpldiewlis
61	padnqkvdqv iilysgdkiy ddyypdlkgr vhftsndlks gdasinvtnl qlsdigtyqc
121	kvkkapgvan kkihlvvlgk mchlqravrp lpeatsavii hpwgpcllpt wkdiprlsit
181	kyqvktlnal lrvrlshllr

Protein sequence isoform 4 (SEQ ID NO (56)):

1	malllcfvll cgvvdfarsl sittpeemie kakgetaylp ckftlspedq gpldiewlis
61	padnqkvdqv grcatskepy vhcqklhrq

Protein sequence isoform 5 (SEQ ID NO (57)):

1	malllcfvll cgvvdfarsl sittpeemie kakgetaylp ckftlspedq gpldiewlis
61	padnqkvdqv iilysgdkiy ddyypdlkgr vhftsndlks gdasinvtnl qlsdigtyqc
121	kvkkapgvan kkihlvvlvk psgarcyvdg seeigsdfki kcepkegslp lqyewqklsd
181	sqkmptswla emtssvisvk nasseysgty sctvrnrvgs dqcllrlnvv ppsnkaglia
241	gaiigtllal aligliifcc rkkrreekye kevhhdired vpppksrtst arsyigsnhs
301	slgsmspsnm egysktqynq vpsedfertp qsptlppakf kypyktdgit vv
Gene ID:	X26
Gene symbol:	CADM4
Gene description:	cell adhesion molecule 4
Unigene:	Hs.370984
Genbank:	AF363368
Entrez Gene:	199731
Refseq:	NM_145296

Protein sequence (SEQ ID NO (58)):

1	mgrarrfqwp llllwaaaag pgagqevqte nvtvaeggva eitcrlhqyd gsivviqnpa
61	rqtlffngtr alkderfqle efsprrvrir lsdarledeg gyfcqlyted thhqiatltv
121	lvapenpvve vreqavegge velsclvprs rpaatlrwyr drkelkgvss sqengkvwsv
181	astvrfrvdr kddggiiice aqnqalpsgh skqtqyvldv qysptariha sqavvregdt
241	lvltcavtgn prpnqirwnr gneslperae avgetltlpg lvsadngtyt ceasnkhgha
301	ralyvlvvyd pgavveaqts vpyaivggil allvfliicv lvgmvwcsvr qkgsylthea
361	sgldeqgear eaflngsdgh krkeeffi
Gene ID:	Y1
Gene symbol:	CLCA2
Gene description:	chloride channel accessory 2
Unigene:	Hs.241551
Genbank:	BC041096
Entrez Gene:	9635
Refseq:	NM_006536

Protein sequence (SEQ ID NO (59)):

1	mtqrsiagpi cnlkfvtllv alsselpflg agvqlqdngy nglliainpq vpenqnlisn
61	ikemiteasf ylfnatkrrv ffrnikilip atwkannnsk ikqesyekan vivtdwygah
121	gddpytlqyr gcgkegkyih ftpnfllndn ltagygsrgr vfvhewahlr wgvfdeynnd
181	kpfyingqnq ikvtressdi tgifvcekgp cpqenciisk lfkegctfiy nstqnatasi
241	mfmqslssvv efcnasthnq eapnlqnqmc slrsawdvit dsadfhhsfp mngtelpppp
301	tfslvqagdk wvclvldvss kmaeadrllq lqqaaefylm qiveihtfvg iasfdskgei
361	raqlhqinsn ddrkllvsyl pttvsaktdi sicsglkkgf evveklngka ygsvmilvts
421	gddkllgncl ptvlssgsti hsialgssaa pnleelsrlt gglkffvpdi snsnsmidaf
481	srissgtgdi fqqhiqlest genvkphhql kntvtvdntv gndtmflvtw qasgppeiil
541	fdpdgrkyyt nnfitnltfr taslwipgta kpghwtytln nthhslqalk vtvtsrasns
601	avppatveaf verdslhfph pvmiyanvkq gfypilnatv tatvepetgd pvtlrllddg
661	agadvikndg iysryffsfa angryslkvh vnhspsistp ahsipgsham yvpgytangn
721	iqmnaprksv grneeerkwg fsrvssggsf svlgvpagph pdvfppckii dleavkveee
781	ltlswtapge dfdqgqatsy eirmskslqn iqddfnnail vntskrnpqq agireiftfs
841	pqistngpeh qpngethesh riyvairamd rnslqsavsn iaqaplfipp nsdpvpardy
901	lilkgvltam gligiiclii vvthhtlsrk kradkkengt kll
Gene ID:	Y2
Gene symbol:	ECM1
Gene description:	extracellular matrix protein 1
Unigene:	Hs.81071
Genbank:	U68187|U68186|AK097046
Entrez Gene:	1893
Refseq:	NM_004425|NM_022664|NM_001202858

Protein sequence isoform 1 (SEQ ID NO (60)):

1	mgttaraalv ltylavasaa seggftatgq rqlrpehfqe vgyaappspp lsrslpmdhp
61	dssqhgppfe gqsqvqppps qeatplqqek llpaqlpaek evgpplpqea vplqkelpsl
121	qhpneqkegt papfgdqshp epeswnaaqh cqqdrsqggw ghrldgfppg rpspdnlnqi
181	clpnrqhvvy gpwnlpqssy shltrqgetl nfleigysrc chershtnrl ecaklvweea
241	msrfceaefs vktrphwcct rqgearfscf qeeapqphyq lracpshqpd issglelpfp
301	pgvptldnik nichlrrfrs vprnlpatdp lqrellaliq lerefqrcer qgnnhtctwk
361	awedtldkyc dreyavkthh hlccrhppsp trdecfarra pypnydrdil tidigrvtpn
421	lmghlcgnqr vltkhkhipg lihnmtarcc dlpfpeqacc aeeekltfin dlcgprrniw
481	rdpalccyls pgdeqvncfn inylrnvalv sgdtenakgq geqgstggtn isstsepkee

Protein sequence isoform 2 (SEQ ID NO (61)):

1	mgttaraalv ltylavasaa seggftatgq rqlrpehfqe vgyaappspp lsrslpmdhp
61	dssqhgppfe gqsqvqppps qeatplqqek llpaqlpaek evgpplpqea vplqkelpsl
121	qhpneqkegt papfgdqshp epeswnaaqh cqqdrsqggw ghrldgfppg rpspdnlnqi
181	clpnrqhvvy gpwnlpqssy shltrqgetl nfleigysre chershtnrl ecaklvwedt
241	ldkycdreya vkthhhlccr hppsptrdec farrapypny drdiltidig rvtpnlmghl
301	cgnqrvltkh khipglihnm tarccdlpfp eqaccaeeek ltfindlcgp rrniwrdpal
361	ccylspgdeq vncfninylr nvalvsgdte nakgqgeqgs tggtnissts epkee

Protein sequence isoform 3 (SEQ ID NO (62)):

1	mgttaraalv ltylavasaa seggftatgq rqlrpehfqe vgyaappspp lsrslpmdhp
61	dssqhgppfe gqsgkegrgp rphsqpwlge rvgcshipps ivqpppsqea tplqqekllp
121	aqlpaekevg pplpqeavpl qkelpslqhp neqkegtpap fgdqshpepe swnaaqhcqq
181	drsqggwghr ldgfppgrps pdnlnqiclp nrqhvvygpw nlpqssyshl trqgetlnfl
241	eigysrcchc rshtnrleca klvweeamsr fceaefsvkt rphwcctrqg earfscfqee
301	apqphyqlra cpshqpdiss glelpfppgv ptldniknic hlrrfrsvpr nlpatdplqr
361	ellaliqler efqrccrqgn nhtctwkawe dtldkycdre yavkthhhlc crhppsptrd
421	ecfarrapyp nydrdiltid igrvtpnlmg hlcgnqrvlt khkhipglih nmtarccdlp
481	fpeqaccaee ekltfindlc gprrniwrdp alccylspgd eqvncfniny lrnvalvsgd
541	tenakgqgeq gstggtniss tsepkee
Gene ID:	Y3
Gene symbol:	CLDN1
Gene description:	claudin 1
Unigene:	Hs.439060
Genbank:	AY358652
Entrez Gene:	9076
Refseq:	NM_021101

Protein sequence (SEQ ID NO (63)):

1	managlqllg filaflgwig aivstalpqw riysyagdni vtaqamyegl wmscvsqstg
61	qiqckvfdsl lnlsstlqat ralmvvgill gviaifvatv gmkcmkcled devqkmrmav
121	iggaifllag lailvatawy gnrivqefyd pmtpvnarye fgqalftgwa aaslcllgga
181	llccscprkt tsyptprpyp kpapssgkdy v
Gene ID:	Y4
Gene symbol:	SFN
Gene description:	stratifin
Unigene:	Hs.523718
Genbank:	AF029082
Entrez Gene:	2810
Refseq:	NM_006142

Protein sequence (SEQ ID NO (64)):

1	merasliqka klaeqaerye dmaafmkgav ekgeelscee rnllsvaykn vvggqraawr
61	vlssieqksn eegseekgpe vreyrekvet elqgvcdtvl glldshlike agdaesrvfy
121	lkmkgdyyry laevatgddk kriidsarsa yqeamdiskk empptnpirl glalnfsvfh
181	yeianspeea islakttfde amadlhtlse dsykdstlim qllrdnltlw tadnageegg
241	eapqepqs
Gene ID:	Y5
Gene symbol:	CD9
Gene description:	CD9 antigen
Unigene:	Hs.114286
Genbank:	AY966455
Entrez Gene:	928
Refseq:	NM_001769

Protein sequence (SEQ ID NO (65)):

1	mpvkggtkci kyllfgfnfi fwlagiavla iglwlrfdsq tksifeqetn nnnssfytgv
61	yiligagalm mlvgflgccg avqesqcmlg lffgfllvif aieiaaaiwg yshkdevike
121	vqefykdtyn klktkdepqr etlkaihyal nccglaggve qfisdicpkk dvletftvks
181	cpdaikevfd nkfhiigavg igiavvmifg mifsmilcca irmremv
Gene ID:	Y6
Gene symbol:	CD109
Gene description:	CD109 antigen
Unigene:	Hs.399891
Genbank:	AF410459
Entrez Gene:	135228
Refseq:	NM_133493|NM_001159587|NM_001159588

Protein sequence isoform 1 (SEQ ID NO (66)):

1	mqgpplltaa hllcvctaal avapgprflv tapgiirpgg nvtigvelle hcpsqvtvka
61	ellktasnlt vsvleaegvf ekgsfktltl pslplnsade iyelrvtgrt qdeilfsnst
121	rlsfetkris vfiqtdkaly kpkqevkfri vtlfsdfkpy ktslnilikd pksnliqqwl
181	sqqsdlgvis ktfqlsshpi lgdwsiqvqv ndqtyyqsfq vseyvlpkfe vtlqtplycs
241	mnskhlngti takytygkpv kgdvtltflp lsfwgkkkni tktfkingsa nfsfndeemk
301	nvmdssngls eyldlsspgp veilttvtes vtgisrnvst nvffkqhdyi ieffdyttvl
361	kpslnftatv kvtradgnql tleerrnnvv itvtqrnyte ywsgsnsgnq kmeavqkiny
421	tvpqsgtfki efpiledsse lqlkayflgs kssmavhslf kspsktyiql ktrdenikvg
481	spfelvvsgn krlkelsymv vsrgqlvavg kqnstmfslt penswtpkac vivyyieddg
541	eiisdvlkip vqlvfknkik lywskvkaep sekvslrisv tqpdsivgiv avdksvnlmn
601	asnditmenv vhelelyntg yylgmfmnsf avfqecglwv ltdanltkdy idgvydnaey
661	aerfmeeneg hivdihdfsl gssphvrkhf petwiwldtn mgyriyqefe vtvpdsitsw
721	vatgfvised lglgltttpv elqafqpffi flnlpysvir geefaleiti fnylkdatev
781	kviieksdkf dilmtsnein atghqqtllv psedgatvlf pirpthlgei pitvtalspt
841	asdavtqmil vkaegieksy sqsilldltd nrlqstlktl sfsfppntvt gservqitai
901	gdvlgpsing laslirmpyg cgeqnminfa pniyildylt kkkqltdnlk ekalsfmrqg
961	yqrellyqre dgsfsafgny dpsgstwlsa fvlrcflead pyididqnvl hrtytwlkgh
1021	qksngefwdp grvihselqg gnkspvtlta yivtsllgyr kyqpnidvqe sihflesefs
1081	rgisdnytla lityalssvg spkakealnm ltwraeqegg mqfwvssesk lsdswqprsl
1141	dievaayall shflqfqtse gipimrwlsr qrnslggfas tqdttvalka lsefaalmnt
1201	ertniqvtvt gpsspspvkf lidthnrlll qtaelavvqp tavnisangf gfaicqlnvv
1261	ynvkasgssr rrrsiqnqea fdldvavken kddlnhvdln vctsfsgpgr sgmalmevnl
1321	lsgfmvpsea islsetvkkv eydhgklnly ldsvnetqfc vnipavrnfk vsntqdasvs
1381	ivdyyeprrq avrsynsevk lsscdlcsdv qgcrpcedga sgshhhssvi fifcfkllyf
1441	melwl

Protein sequence isoform 2 (SEQ ID NO (67)):

1	mqgpplltaa hllcvctaal avapgprflv tapgiirpgg nvtigvelle hcpsqvtvka
61	ellktasnlt vsvleaegvf ekgsfktltl pslplnsade iyelrvtgrt qdeilfsnst
121	rlsfetkris vfiqtdkaly kpkqevkfri vtlfsdfkpy ktslnilikd pksnliqqwl
181	sqqsdlgvis ktfqlsshpi lgdwsiqvqv ndqtyyqsfq vseyvlpkfe vtlqtplycs
241	mnskhlngti takytygkpv kgdvtltflp lsfwgkkkni tktfkingsa nfsfndeemk
301	nvmdssngls eyldlsspgp veilttvtes vtgisrnvst nvffkqhdyi ieffdyttvl
361	kpslnftatv kvtradgnql tleerrnnvv itvtqrnyte ywsgsnsgnq kmeavqkiny
421	tvpqsgtfki efpiledsse lqlkayflgs kssmavhslf kspsktyiql ktrdenikvg
481	spfelvvsgn krlkelsymv vsrgqlvavg kqnstmfslt penswtpkac vivyyieddg
541	eiisdvlkip vqlvfknkik lywskvkaep sekvslrisv tqpdsivgiv avdksvnlmn
601	asnditmenv vhelelyntg yylgmfmnsf avfqecglwv ltdanltkdy idgvydnaey
661	aerfmeeneg hivdihdfsl gssphvrkhf petwiwldtn mgyriyqefe vtvpdsitsw
721	vatgfvised lglgltttpv elqafqpffi flnlpysvir geefaleiti fnylkdatev
781	kviieksdkf dilmtsnein atghqqtllv psedgatvlf pirpthlgei pitvtalspt
841	asdavtqmil vkaegieksy sqsillditd nrlqstiktl sfsfppntvt gservqitai
901	gdvlgpsing laslirmpyg cgeqnminfa pniyildylt kkkqltdnlk ekalsfmrqg
961	yqrellyqre dgsfsafgny dpsgstwlsa fvlrcflead pyididqnvl hrtytwlkgh
1021	qksngefwdp grvihselqg gnkspvtlta yivtsllgyr kyqpnidvqe sihflesefs
1081	rgisdnytla lityalssvg spkakealnm ltwraeqegg mqfwvssesk lsdswqprsl
1141	dievaayall shflqfqtse gipimrwlsr qrnslggfas tqdttvalka lsefaalmnt
1201	ertniqvtvt gpsspsplav vqptavnisa ngfgfaicql nvvynvkasg ssrrrrsiqn
1261	qeafdldvav kenkddlnhv dinvctsfsg pgrsgmalme vnllsgfmvp seaislsetv
1321	kkveydhgkl nlyldsvnet qfcvnipavr nfkvsntqda svsivdyyep rrqavrsyns
1381	evklsscdlc sdvqgcrpce dgasgshhhs svififcfkl lyfmelwl

Protein sequence isoform 3 (SEQ ID NO (68)):

1	mqgpplltaa hllcvctaal avapgprflv tapgiirpgg nvtigvelle hcpsqvtvka
61	ellktasnlt vsvleaegvf ekgsfktltl psdpksnliq qwlsqqsdlg visktfqlss
121	hpilgdwsiq vqvndqtyyq sfqvseyvlp kfevtlqtpl ycsmnskhin gtitakytyg
181	kpvkgdvtlt flplsfwgkk knitktfkin gsanfsfnde emknvmdssn glseyldlss
241	pgpveilttv tesvtgisrn vstnvffkqh dyiieffdyt tvlkpslnft atvkvtradg
301	nqltleerrn nvvitvtqrn yteywsgsns gnqkmeavqk inytvpqsgt fkiefpiled
361	sselqlkayf lgskssmavh slfkspskty iqlktrdeni kvgspfelwv sgnkrlkels
421	ymvvsrgqlv avgkqnstmf sltpenswtp kacvivyyie ddgeiisdvl kipvqlvfkn
481	kiklywskvk aepsekvslr isvtqpdsiv givavdksvn lmnasnditm enwvhelely
541	ntgyylgmfm nsfavfqecg lwvltdanlt kdyidgvydn aeyaerfmee neghivdihd
601	fslgssphvr khfpetwiwl dtnmgyriyq efevtvpdsi tswvatgfvi sedlglgltt
661	tpvelqafqp ffiflnlpys virgeefale itifnylkda tevkviieks dkfdilmtsn
721	einatghqqt llvpsedgat vlfpirpthl geipitvtal sptasdavtq milvkaegie
781	ksysqsilld ltdnrlqstl ktlsfsfppn tvtgservqi taigdvlgps inglaslirm
841	pygcgeqnmi nfapniyild yltkkkqltd nlkekalsfm rqgyqrelly qredgsfsaf
901	gnydpsgstw lsafvlrcfl eadpyididq nvlhrtytwl kghqksngef wdpgrvihse
961	lqggnkspvt ltayivtsll gyrkyqpnid vqesihfles efsrgisdny tlalityals
1021	svgspkakea lnmltwraeq eggmqfwvss esklsdswqp rsldievaay allshflqfq
1081	tsegipimrw lsrqrnslgg fastqdttva lkalsefaal mntertniqv tvtgpsspsp
1141	vkflidthnr lllqtaelav vqptavnisa ngfgfaicql nvvynvkasg ssrrrrsiqn
1201	qeafdldvav kenkddlnhv dinvctsfsg pgrsgmalme vnllsgfmvp seaislsetv
1261	kkveydhgkl nlyldsvnet qfcvnipavr nfkvsntqda svsivdyyep rrqavrsyns
1321	evklsscdlc sdvqgcrpce dgasgshhhs svififcfkl lyfmelwl
Gene ID:	Y7
Gene symbol:	ITGB8
Gene description:	integrin, beta 8
Unigene:	Hs.592171
Genbank:	M73780
Entrez Gene:	3696
Refseq:	NM_002214

Protein sequence (SEQ ID NO (69)):

1	mcgsalafft aafvclqndr rgpasflwaa wvfslvlglg qgednrcass naascarcla
61	lgpecgwcvq edfisggsrs ercdivsnli skgcsvdsie ypsvhviipt eneintqvtp
121	gevsiqlrpg aeanfmlkvh plkkypvdly ylvdvsasmh nnieklnsvg ndlsrkmaff
181	srdfrlgfgs yvdktvspyi sihperihnq csdynldcmp phgyihvlsl tenitefeka
241	vhrqkisgni dtpeggfdam lqaavceshi gwrkeakril lvmtdqtshl aldsklagiv
301	vpndgnchlk nnvyvksttm ehpslgqlse klidnninvi favqgkqfhw ykdllpllpg
361	tiageieska anlnnlvvea yqklisevkv qvenqvqgiy fnitaicpdg srkpgmeger
421	nvtsndevlf nvtvtmkkcd vtggknyaii kpigfnetak ihihrncscq cednrgpkgk
481	cvdetfldsk cfqcdenkch fdedqfsses ckshkdqpvc sgrgvcvcgk cschkiklgk
541	vygkycekdd fscpyhhgnl caghgeceag rcqcfsgweg drcqcpsaaa qhcvnskgqv
601	csgrgtcvcg rcectdprsi grfcehcptc ytackenwnc mqclhphnls qaildqckts
661	calmeqqhyv dqtsecfssp sylriffiif ivtfligllk vliirqvilq wnsnkiksss
721	dyrvsaskkd klilqsvctr avtyrrekpe eikmdiskln ahetfrcnf
Gene ID:	Y8
Gene symbol:	EMP2
Gene description:	epithelial membrane protein 2
Unigene:	Hs.531561
Genbank:	BC009687
Entrez Gene:	2013
Refseq:	NM_001424

Protein sequence (SEQ ID NO (70)):

1	mlvllafiia fhitsaallf iatvdnawwv gdeffadvwr ictnntnctv indsfqeyst
61	lqavqatmil stilcciaff ifvlqlfrlk qgerfvltsi iqlmsclcvm iaasiytdrr
121	edihdknakf ypvtregsyg ysyilawvaf actfisgmmy lilrkrk
Gene ID:	Y9
Gene symbol:	FGFBP1
Gene description:	fibroblast growth factor binding protein 1
Unigene:	Hs.1690
Genbank:	BC008910
Entrez Gene:	9982
Refseq:	NM_005130

Protein sequence (SEQ ID NO (71)):

1	mkicsltlls flllaaqvll vegkkkvkng lhskvvseqk dtlgntqikq ksrpgnkgkf
61	vtkdqancrw aateqeegis lkvectqldh efscvfagnp tsclklkder vywkqvarnl
121	rsqkdicrys ktavktrvcr kdfpessikl vsstlfgntk prkektemsp rehikgkett
181	psslavtqtm atkapecved pdmanqrkta lefcgetwss lctfflsivq dtsc
Gene ID:	Y10
Gene symbol:	CDH3
Gene description:	cadherin 3, type 1, P-cadherin (placental)
Unigene:	Hs.191842
Genbank:	BC041846
Entrez Gene:	1001
Refseq:	NM_001793

Protein sequence (SEQ ID NO (72)):

1	mglprgplas llllqvcwlq caasepcrav freaevtlea ggaeqepgqa lgkvfmgcpg
61	qepalfstdn ddftvrnget vqerrslker nplkifpskr ilrrhkrdwv vapisvpeng
121	kgpfpqrinq lksnkdrdtk ifysitgpga dsppegvfav eketgwllln kpldreeiak
181	yelfghavse ngasvedpmn isiivtdqnd hkpkftqdtf rgsvlegvlp gtsvmqvtat
241	deddaiytyn gvvaysihsq epkdphdlmf tihrstgtis vissgldrek vpeytltiqa
301	tdmdgdgstt tavavveild andnapmfdp qkyeahvpen avghevqrlt vtdldapnsp
361	awratylimg gddgdhftit thpesnqgil ttrkgldfea knqhtlyvev tneapfvlkl
421	ptstativvh vedvneapvf vppskvvevq egiptgepvc vytaedpdke nqkisyrilr
481	dpagwlamdp dsgqvtavgt ldredeqfvr nniyevmvla mdngsppttg tgtllltlid
541	vndhgpvpep rqiticnqsp vrqvlnitdk dlsphtspfq aqltddsdiy wtaevneegd
601	tvvlslkkfl kqdtydvhls lsdhgnkeql tviratvcdc hghvetcpgp wkggfilpvl
661	gavlallfll lvllllvrkk rkikeplllp eddtrdnvfy ygeegggeed qdyditqlhr
721	glearpevvl rndvaptiip tpmyrprpan pdeignfiie nlkaantdpt appydtllvf
781	dyegsgsdaa slssltssas dqdqdydyln ewgsrfkkla dmygggedd
Gene ID:	Y11
Gene symbol:	ITGB4
Gene description:	integrin, beta 4
Unigene:	Hs.632226
Genbank:	X53587
Entrez Gene:	3691
Refseq:	NM_000213|NM_001005619|NM_001005731

Protein sequence isoform 1 (SEQ ID NO (73)):

1	magprpspwa rlllaalisv slsgtlanrc kkapvkscte cvrvdkdcay ctdemfrdrr
61	cntqaellaa gcqresivvm essfqiteet qidttirrsq mspqglrvrl rpgeerhfel
121	evfeplespv dlyilmdfsn smsddldnik kmgqnlarvl sqltsdytig fgkfvdkvsv
181	pqtdmrpekl kepwpnsdpp fsfknvisit edvdefrnkl qgerisgnld apeggfdail
241	qtavctrdig wrpdsthllv fstesafhye adganvlagi msrnderchl dttgtytqyr
301	tqdypsvptl vrllakhnii pifavtnysy syyeklhtyf pvsslgvlqe dssnivelle
361	eafnrirsnl diraldsprg lrtevtskmf qktrtgsfhi rrgevgiyqv qlralehvdg
421	thvcqlpedq kgnihlkpsf sdglkmdagi icdvctcelq kevrsarcsf ngdfvcgqcv
481	csegwsgqtc nestgslsdi qpclregedk pcsgrgecqc ghcvcygegr yegqfceydn
541	fqcprtsgfl cndrgresmg qcvcepgwtg pscdcplsna tcidsnggic ngrghcecgr
601	chchqqslyt dticeinysa ihpglcedir scvqcqawgt gekkgrtcee cnfkvkmvde
661	lkraeevvvr csfrdedddc tysytmegdg apgpnstvlv hkkkdcppgs fwwlipllll
721	llpllallll lcwkycacck aclallpccn rghmvgfked hymlrenlma sdhldtpmlr
781	sgnlkgrdvv rwkvtnnmqr pgfathaasi nptelvpygl sirlaricte nilkpdtrec
841	aqlrqeveen lnevyrqisg vhklqqtkfr qqpnagkkqd htivdtvlma prsakpallk
901	ltekqveqra fhdlkvapgy ytltadqdar gmvefqegve lvdvrvplfi rpedddekql
961	lveaidvpag tatlgrrlvn itiikeqard vvsfeqpefs vsrgdqvari pvirrvldgg
1021	ksqvsyrtqd gtaqgnrdyi pvegellfqp geawkelqvk llelqevdsl lrgrqvrrfh
1081	vqlsnpkfga hlgqphstti iirdpdeldr sftsqmlssq ppphgdlgap qnpnakaags
1141	rkihfnwlpp sgkpmgyrvk ywiqgdsese ahlldskvps veltnlypyc dyemkvcayg
1201	aqgegpyssl vscrthqevp sepgrlafnv vsstvtqlsw aepaetngei tayevcyglv
1261	nddnrpigpm kkvlvdnpkn rmllienlre sqpyrytvka rngagwgper eaiinlatqp
1321	krpmsipiip dipivdaqsg edydsflmys ddvirspsgs qrpsvsddtg cgwkfepllg
1381	eeldlrrvtw rlppeliprr sassgrssda eaphgppddg gaggkggslp rsatpgppge
1441	hlvngrmdfa fpgstnslhr mtttsaaayg thisphvphr vlstsstltr dynsltrseh
1501	shsttlprdy stltsvsshd srltagvpdt ptrivfsalg ptslrvswqe prcerplqgy
1561	sveyqllngg elhrlnipnp aqtsvvvedl lpnhsyvfrv raqsqegwgr eregvities
1621	qvhpqsplcp lpgsaftist psapgplvft alspdslqls werprrpngd ivgylvtcem
1681	aqgggpataf rvdgdspesr ltvpglsenv pykfkvqart tegfgpereg iitiesqdgg
1741	pfpqlgsrag lfqhplqsey ssittthtsa tepflvdglt lgaqhleagg sltrhvtqef
1801	vsrtlttsgt lsthmdqqff qt

Protein sequence isoform 2 (SEQ ID NO (74)):

1	magprpspwa rlllaalisv slsgtlanrc kkapvkscte cvrvdkdcay ctdemfrdrr
61	cntqaellaa gcqresivvm essfqiteet qidttlrrsq mspqglrvrl rpgeerhfel
121	evfeplespv dlyilmdfsn smsddldnik kmgqnlarvl sqltsdytig fgkfvdkvsv
181	pqtdmrpekl kepwpnsdpp fsfknvislt edvdefrnkl qgerisgnld apeggfdail
241	qtavctrdig wrpdsthllv fstesafhye adganvlagi msrnderchl dttgtytqyr
301	tqdypsvptl vrllakhnii pifavtnysy syyeklhtyf pvsslgvlqe dssnivelle
361	eafnrirsnl diraldsprg lrtevtskmf qktrtgsfhi rrgevgiyqv qlralehvdg
421	thvcqlpedq kgnihlkpsf sdglkmdagi icdvctcelq kevrsarcsf ngdfvcgqcv
481	csegwsgqtc ncstgslsdi qpclregedk pcsgrgecqc ghcvcygegr yegqfceydn
541	fqcprtsgfl cndrgresmg qcvcepgwtg pscdcplsna tcidsnggic ngrghcecgr
601	chchqqslyt dticeinysa ihpglcedlr scvqcqawgt gekkgrtcee cnfkvkmvde
661	lkraeevvvr csfrdedddc tysytmegdg apgpnstvlv hkkkdcppgs fwwlipllll
721	llpllallll lcwkycacck aclallpccn rghmvgfked hymlrenlma sdhldtpmlr
781	sgnlkgrdvv rwkvtnnmqr pgfathaasi nptelvpygl slrlarlcte nllkpdtrec
841	aqlrqeveen lnevyrqisg vhklqqtkfr qqpnagkkqd htivdtvlma prsakpallk
901	ltekqveqra fhdlkvapgy ytltadqdar gmvefqegve lvdvrvplfi rpedddekql
961	lveaidvpag tatlgrrlvn itiikeqard vvsfeqpefs vsrgdqvari pvirrvldgg
1021	ksqvsyrtqd gtaqgnrdyi pvegellfqp geawkelqvk llelqevdsl lrgrqvrrfh
1081	vqlsnpkfga hlgqphstti iirdpdeldr sftsqmlssq ppphgdlgap qnpnakaags
1141	rkihfnwlpp sgkpmgyrvk ywiqgdsese ahlldskvps veltnlypyc dyemkvcayg
1201	aqgegpyssl vscrthqevp sepgrlafnv vsstvtqlsw aepaetngei tayevcyglv
1261	nddnrpigpm kkvlvdnpkn rmllienlre sqpyrytvka rngagwgper eaiinlatqp
1321	krpmsipiip dipivdaqsg edydsflmys ddvlrspsgs qrpsvsddte hlvngrmdfa
1381	fpgstnslhr mtttsaaayg thisphvphr vlstsstltr dynsltrseh shsttlprdy
1441	stltsvsshg lppiwehgrs rlplswalgs rsraqmkgfp psrgprdsii lagrpaapsw
1501	gpdsrltagv pdtptrlvfs algptsirvs wqeprcerpl qgysveyqll nggelhrlni
1561	pnpaqtsvvv edllpnhsyv frvraqsqeg wgreregvit iesqvhpqsp lcplpgsaft
1621	lstpsapgpl vftalspdsl qlswerprrp ngdivgylvt cemaqgggpa tafrvdgdsp
1681	esrltvpgls envpykfkvq arttegfgpe regiitiesq dggpfpqlgs raglfqhplq
1741	seyssittth tsatepflvd gltlgaqhle aggsltrhvt qefvsrtltt sgtlsthmdq
1801	qffqt

Protein sequence isoform 3 (SEQ ID NO (75)):

1	magprpspwa rlllaalisv slsgtlanrc kkapvkscte cvrvdkdcay ctdemfrdrr
61	cntqaellaa gcqresivvm essfqiteet qidttlrrsq mspqglrvrl rpgeerhfel
121	evfeplespv dlyilmdfsn smsddldnik kmgqnlarvl sqltsdytig fgkfvdkvsv
181	pqtdmrpekl kepwpnsdpp fsfknvisit edvdefrnkl qgerisgnld apeggfdail
241	qtavctrdig wrpdsthllv fstesafhye adganvlagi msrnderchl dttgtytqyr
301	tqdypsvptl vrllakhnii pifavtnysy syyeklhtyf pvsslgvlqe dssnivelle
361	eafnrirsnl diraldsprg lrtevtskmf qktrtgsfhi rrgevgiyqv qlralehvdg
421	thvcqlpedq kgnihlkpsf sdglkmdagi icdvctcelq kevrsarcsf ngdfvcgqcv
481	csegwsgqtc ncstgslsdi qpclregedk pcsgrgecqc ghcvcygegr yegqfceydn
541	fqcprtsgfl cndrgrcsmg qcvcepgwtg pscdcplsna tcidsnggic ngrghcecgr
601	chchqqslyt dticeinysa ihpglcedlr scvqcqawgt gekkgrtcee cnfkvkmvde
661	lkraeevvvr csfrdedddc tysytmegdg apgpnstvlv hkkkdcppgs fwwlipllll
721	llpllallll lcwkycacck aclallpccn rghmvgfked hymlrenlma sdhldtpmlr
781	sgnlkgrdvv rwkvtnnmqr pgfathaasi nptelvpygl sirlaricte nllkpdtrec
841	aqlrqeveen lnevyrqisg vhklqqtkfr qqpnagkkqd htivdtvlma prsakpallk
901	ltekqveqra fhdlkvapgy ytltadqdar gmvefqegve lvdvrvplfi rpedddekql
961	lveaidvpag tatlgrrlvn itiikeqard wvsfeqpefs vsrgdqvari pvirrvldgg
1021	ksqvsyrtqd gtaqgnrdyi pvegellfqp geawkelqvk llelqevdsl lrgrqvrrfh
1081	vqlsnpkfga hlgqphstti iirdpdeldr sftsqmissq ppphgdlgap qnpnakaags
1141	rkihfnwlpp sgkpmgyrvk ywiqgdsese ahlldskvps veltnlypyc dyemkvcayg
1201	aqgegpyssl vscrthqevp sepgrlafnv vsstvtqlsw aepaetngei tayevcyglv
1261	nddnrpigpm kkvlvdnpkn rmllienlre sqpyrytvka rngagwgper eaiinlatqp
1321	krpmsipiip dipivdaqsg edydsflmys ddvlrspsgs qrpsvsddte hlvngrmdfa
1381	fpgstnslhr mtttsaaayg thisphvphr vlstsstltr dynsltrseh shsttlprdy
1441	stltsvsshd srltagvpdt ptrivfsalg ptslrvswqe prcerplqgy sveyqllngg
1501	elhrlnipnp aqtsvwvedl lpnhsyvfrv raqsqegwgr eregvities qvhpqsplcp
1561	lpgsaftlst psapgplvft alspdslqls werprrpngd ivgylvtcem aqgggpataf
1621	rvdgdspesr ltvpglsenv pykfkvqart tegfgpereg iitiesqdgg pfpqlgsrag
1681	lfqhplqsey ssittthtsa tepflvdglt lgaqhleagg sltrhvtqef vsrtlttsgt
1741	lsthmdqqff qt
Gene ID:	Y12
Gene symbol:	LAMB3
Gene description:	laminin, beta 3
Unigene:	Hs.497636
Genbank:	BC075838
Entrez Gene:	3914
Refseq:	NM_000228

Protein sequence (SEQ ID NO (76)):

1	mrpffllcfa lpgllhaqqa csrgacyppv gdllvgrtrf lrasstcglt kpetyctqyg
61	ewqmkcckcd srqphnyysh rvenvasssg pmrwwqsqnd vnpvslqldl drrfqlqevm
121	mefqgpmpag mlierssdfg ktwrvyqyla adctstfprv rqgrpqswqd vrcqslpqrp
181	narlnggkvq lnlmdlvsgi patqsqkiqe vgeitnlrvn ftrlapvpqr gyhppsayya
241	vsqlrlqgsc fchghadrca pkpgasagps tavqvhdvcv cqhntagpnc ercapfynnr
301	pwrpaegqda hecqrcdcng hsetchfdpa vfaasqgayg gvcdncrdht egkncercql
361	hyfrnrrpga siqetcisce cdpdgavpga pcdpvtgqcv ckehvqgerc dickpgftgl
421	tyanpqgchr cdcnilgsrr dmpcdeesgr clclpnvvgp kcdqcapyhw klasgqgcep
481	cacdphnsls pqcnqftgqc pcregfggim csaaairqcp drtygdvatg cracdcdfrg
541	tegpgcdkas grclcrpglt gpredqcqrg ycnrypvcva chpcfqtyda dlreqalrfg
601	rlrnataslw sgpgledrgl asrildaksk ieqiravlss pavteqevaq vasailslrr
661	tlqglqldip leeetlsipr dlesidrsfn glltmyqrkr eqfekissad psgafrmlst
721	ayeqsaqaaq qvsdssrlld qlrdsrreae rlvrqagggg gtgspklval rlemsslpdl
781	tptfnklcgn srqmactpis cpgelcpqdn gtacgsrcrg vlpraggafl magqvaeqlr
841	gfnaqlqrtr qmiraaeesa sqiqssaqrl etqvsasrsq meedvrrtrl liqqvrdflt
901	dpdtdaatiq evseavlalw lptdsatvlq kmneiqaiaa rlpnvdlvls qtkqdiarar
961	rlqaeaeear srahavegqv edvvgnlrqg tvalqeaqdt mqgtsrslrl iqdrvaevqq
1021	vlrpaeklvt smtkqlgdfw trmeelrhqa rqqgaeavqa qqlaegaseq alsaqegfer
1081	ikqkyaelkd rlgqssmlge qgariqsvkt eaeelfgetm emmdrmkdme lellrgsqai
1141	mlrsadltgl ekrveqirdh ingrvlyyat ck
Gene ID:	Y13
Gene symbol:	CD55
Gene description:	CD55 antigen
Unigene:	Hs.126517
Genbank:	M31516
Entrez Gene:	1604
Refseq:	NM_000574

Protein sequence (SEQ ID NO (77)):

1	mtvarpsvpa alpllgelpr llllvllclp avwgdcglpp dvpnaqpale grtsfpedtv
61	itykceesfv kipgekdsvi clkgsqwsdi eefcnrscev ptrinsaslk qpyitqnyfp
121	vgtvveyecr pgyrrepsls pkltclqnlk wstavefckk kscpnpgeir ngqidvpggi
181	lfgatisfsc ntgyklfgst ssfclisgss vqwsdplpec reiycpappq idngiiqger
241	dhygyrqsvt yacnkgftmi gehsiyctvn ndegewsgpp pecrgkslts kvpptvqkpt
301	tvnvpttevs ptsqktttkt ttpnaqatrs tpvsrttkhf hettpnkgsg ttsgttrlls
361	ghtcftltgl lgtlvtmgll t
Gene ID:	Y14
Gene symbol:	CLDN16
Gene description:	claudin 16
Unigene:	Hs.251391
Genbank:	BC069682
Entrez Gene:	10686
Refseq:	NM_006580

Protein sequence (SEQ ID NO (78)):

1	mtsrtpllvt aclyysycns rhlqqgvrks krpvfshcqv petqktdtrh lsgaragvcp
61	cchpdgllat mrdllqyiac ffaffsagfl ivatwtdcwm vnaddslevs tkcrglwwec
121	vtnafdgirt cdeydsilae hplklvvtra lmitadilag fgfltlllgl dcvkflpdep
181	yikvricfva gatlliagtp giigsvwyav dvyverstlv lhniflgiqy kfgwscwlgm
241	agslgcflag avltcclylf kdvgpernyp yslrkaysaa gvsmaksysa prtetakmya
301	vdtrv
Gene ID:	Y15
Gene symbol:	LAMA3
Gene description:	laminin, alpha 3
Unigene:	Hs.436367
Genbank:	AY327115
Entrez Gene:	3909
Refseq:	NM_198129|NM_001127717|NM_000227|NM_001127718

Protein sequence isoform 1 (SEQ ID NO (79)):

1	maaaarprgr algpvlpptp llllvlrvlp acgatardpg aaaglslhpt yfnlaeaari
61	watatcgerg pgegrpqpel ycklvggpta pgsghtiqgq fcdycnsedp rkahpvtnai
121	dgserwwqsp plssgtqynr vnltldlgql fhvayilikf ansprpdlwv lersvdfgst
181	yspwqyfahs kvdclkefgr eanmavtrdd dvlcvteysr ivplengevv vslingrpga
241	knftfshtlr eftkatnirl rflrtntllg hliskaqrdp tvtrryyysi kdisiggqcv
301	cnghaevcni nnpeklfrce cqhhtcgetc drcctgynqr rwrpaaweqs heceacnchg
361	hasncyydpd verqqasint qgiyagggvc incqhntagv nceqcakgyy rpygvpvdap
421	dgcipcscdp ehadgceqgs grchckpnfh gdncekcaig yynfpfclri pifpvstpss
481	edpvagdikg cdcnlegvlp eicdahgrcl crpgvegprc dtcrsgfysf picqacwcsa
541	lgsyqmpcss vtgqcecrpg vtgqrcdrel sgaydfphcq gsssacdpag tinsnlgycq
601	cklhvegptc srckllywnl dkenpsgcse ckchkagtvs gtgecrqgdg dchckshvgg
661	dscdtcedgy faleksnyfg cqgcqcdigg alssmcsgps gvcqcrehww gkvcqrpenn
721	yyfpdlhhmk yeiedgstpn grdlrfgfdp lafpefswrg yaqmtsvqnd vritlnvgks
781	sgslfrvilr yvnpgteavs ghitiypswg aaqskeiifl pskepafvtv pgngfadpfs
841	itpgiwvaci kaegvlldyl vilprdyyea sviqlpvtep cayagppqen cllyqhlpvt
901	rfpctlacea rhflldgepr pvavrqptpa hpvmvdlsgr evelhirlri pqvghyvvvv
961	eysteaaqlf vvdvnvkssg svlagqvniy scnysvlcrs avidhmsria myelladadi
1021	qlkghmarfl lhqvciipie efsaeyvrpq vhciasygrf vnqsatcvsl ahetpptali
1081	ldvlsgrpfp hlpqqsspsv dvlpgvtlka pqnqvtlrgr vphlgryvfv ihfyqaahpt
1141	fpaqvsvdgg wpragsfhas fcphvlgcrd qviaegqief disepevaat vkvpegkslv
1201	lvrvlvvpae nydyqilhkk smdkslefit ncgknsfyld pqtasrfckn sarslvafyh
1261	kgalpcechp tgatgphcsp eggqcpcqpn vigrqctrca tghygfprck pcscgrrice
1321	emtgqcrepp rtvrpqcevc ethsfsfhpm agcegencsr rgtieaampe cdrdsgqcrc
1381	kpritgrqcd rcasgfyrfp ecvpcncnrd gtepgvcdpg tgaclckenv egtecnvcre
1441	gsfhldpanl kgctscfcfg vnnqchsshk rrtkfvdmlg whletadrvd ipvsfnpgsn
1501	smvadlqelp atihsaswva ptsylgdkvs syggyltyqa ksfglpgdmv llekkpdvql
1561	tgqhmsiiye etntprpdrl hhgrvhvveg nfrhassrap vsreelmtvl srladvriqg
1621	lyftetqrit lsevgleeas dtgsgriala veicacppay agdscqgcsp gyyrdhkgly
1681	tgrcvpcncn ghsnqcqdgs gicvncqhnt agehcercqe gyygnavhgs cracpcphtn
1741	sfatgcvvng gdvrcsckag ytgtqcerca pgyfgnpqkf ggscqpcscn sngqlgschp
1801	ltgdcinqep kdsspaeecd dcdscvmtll ndlatmgeql rlvksqlqgl sasaglleqm
1861	rhmetqakdl rnqllnyrsa isnhgskieg lereltdlnq efetlqekaq vnsrkaqtln
1921	nnvnratqsa keldvkiknv irnvhillkq isgtdgegnn vpsgdfsrew aeaqrmmrel
1981	rnrnfgkhlr eaeadkresq lllnrirtwq kthqgenngl ansirdslne yeaklsdlra
2041	rlqeaaaqak qanglngene ralgaiqrqv keinslqsdf tkylttadss llqtnialql
2101	meksqkeyek laaslnearq elsdkvrels rsagktslve eaekharslq elakqleeik
2161	rnasgdelvr cavdaataye nilnaikaae daanraasas esalqtvike dlprkaktls
2221	snsdklinea kmtqkklkqe vspalnnlqq tlnivtvqke vidtnittlr dglhgiqrgd
2281	idamissaks mvrkanditd evldglnpiq tdverikdty grtqnedfkk altdadnsvn
2341	kltnklpdlw rkiesinqql lplgnisdnm drireliqqa rdaaskvavp mrfngksgve
2401	vrlpndledl kgytslslfl qrpnsrengg tenmfvmylg nkdasrdyig mavvdgqltc
2461	vynlgdreae lqvdqiltks etkeavmdrv kfqriyqfar lnytkgatss kpetpgvydm
2521	dgrnsntlln ldpenvvfyv ggyppdfklp srlsfppykg cielddlnen vislynfkkt
2581	fnlnttevep crrrkeesdk nyfegtgyar vptqphapip tfgqtiqttv drgllffaen
2641	gdrfislnie dgklmvrykl nselpkergv gdainngrdh siqikigklq krmwinvdvq
2701	ntiidgevfd fstyylggip iairerfnis tpafrgcmkn lkktsgwvrl ndtvgvtkkc
2761	sedwklvrsa sfsrggqlsf tdlglpptdh lqasfgfqtf qpsgilldhq twtrnlqvtl
2821	edgyielsts dsgspifksp qtymdgllhy vsvisdnsgl rlliddqllr nskrlkhiss
2881	srqslriggs nfegcisnvf vqrlslspev ldltsnsikr dvslggcsin kppflmllkg
2941	strfnktktf rinqllqdtp vasprsvkvw qdacsplpkt qanhgalqfg diptshllfk
3001	lpqellkprs qfavdmqtts srglvfhtgt knsfmalyls kgrlvfalgt dgkklriksk
3061	ekcndgkwht vvfghdgekg rlvvdglrar egslpgnsti sirapvylgs ppsgkpkslp
3121	tnsfvgclkn fqldskplyt psssfgvssc lggplekgiy fseegghvvl ahsvllgpef
3181	klvfsirprs ltgilihigs qpgkhlcvyl eagkvtasmd sgaggtstsv tpkqslcdgq
3241	whsvavtikq hilhleldtd ssytagqipf ppastqeplh lggapanltt lripvwksff
3301	gclrnihvnh ipvpvteale vqgpvslngc pdq

Protein sequence isoform 3 (SEQ ID NO (80)):

1	maaaarprgr algpvlpptp llllvlrvlp acgatardpg aaaglslhpt yfnlaeaari
61	watatcgerg pgegrpqpel ycklvggpta pgsghtiqgq fcdycnsedp rkahpvtnai
121	dgserwwqsp plssgtqynr vnitldlgql fhvayilikf ansprpdlwv lersvdfgst
181	yspwqyfahs kvdclkefgr eanmavtrdd dvlcvteysr ivplengevv vslingrpga
241	knftfshtlr eftkatnirl rflrtntllg hliskaqrdp tvtrryyysi kdisiggqcv
301	cnghaevcni nnpeklfrce cqhhtcgetc drectgynqr rwrpaaweqs heceacnchg
361	hasncyydpd verqqasint qgiyagggvc incqhntagv nceqcakgyy rpygvpvdap
421	dgcipcscdp ehadgceqgs grchckpnfh gdncekcaig yynfpfclri pifpvstpss
481	edpvagdikg cdcnlegvlp eicdahgrel crpgvegprc dtcrsgfysf picqacwcsa
541	lgsyqmpcss vtgqcecrpg vtgqrcdrel sgaydfphcq gsssacdpag tinsnlgycq
601	cklhvegptc srckllywnl dkenpsgcse ckchkagtvs gtgecrqgdg dchckshvgg
661	dscdtcedgy faleksnyfg cqgcqcdigg alssmcsgps gvcqcrehww gkvcqrpenn
721	yyfpdlhhmk yeiedgstpn grdlrfgfdp lafpefswrg yaqmtsvqnd vritinvgks
781	sgslfrvilr yvnpgteavs ghitiypswg aaqskeiifl pskepafvtv pgngfadpfs
841	itpgiwvaci kaegvlldyl vilprdyyea sviqlpvtep cayagppqen cllyqhlpvt
901	rfpctlacea rhflldgepr pvavrqptpa hpvmvdlsgr evelhirlri pqvghyvvvv
961	eysteaaqlf vvdvnvkssg svlagqvniy scnysvlcrs avidhmsria myelladadi
1021	qlkghmarfl lhqvciipie efsaeyvrpq vhciasygrf vnqsatcvsl ahetpptali
1081	ldvlsgrpfp hlpqqsspsv dvlpgvtlka pqnqvtlrgr vphlgryvfv ihfyqaahpt
1141	fpaqvsvdgg wpragsfhas fcphvlgerd qviaegqief disepevaat vkvpegkslv
1201	lvrvlvvpae nydyqilhkk smdkslefit ncgknsfyld pqtasrfckn sarslvafyh
1261	kgalpcechp tgatgphcsp eggqcpcqpn vigrqctrca tghygfprck pcscgrrice
1321	emtgqcrepp rtvrpqcevc ethsfsfhpm agcegencsr rgtieaampe cdrdsgqcrc
1381	kpritgrqcd rcasgfyrfp ecvpcncnrd gtepgvcdpg tgaclckenv egtecnvcre
1441	gsfhldpanl kgctscfcfg vnnqchsshk rrtkfvdmlg whletadrvd ipvsfnpgsn
1501	smvadlqelp atihsaswva ptsylgdkvs syggyltyqa ksfglpgdmv llekkpdvql
1561	tgqhmsiiye etntprpdrl hhgrvhwveg nfrhassrap vsreelmtvl srladvriqg
1621	lyftetqrlt lsevgleeas dtgsgriala veicacppay agdscqgcsp gyyrdhkgly
1681	tgrcvpcncn ghsnqcqdgs gicvncqhnt agehcercqe gyygnavhgs cracpcphtn
1741	sfatgcvvng gdvresckag ytgtqcerca pgyfgnpqkf ggscqpcsen sngqlgschp
1801	ltgdcinqep kdsspaeecd dcdscvmtll ndlatmgeql rlvksqlqgl sasaglleqm
1861	rhmetqakdl rnqllnyrsa isnhgskieg lereltdlnq efetlqekaq vnsrkaqtln
1921	nnvnratqsa keldvkiknv irnvhmlnri rtwqkthqge nnglansird slneyeakls
1981	dlrarlqeaa aqakqangln generalgai qrqvkeinsl qsdftkyltt adssllqtni
2041	alqlmeksqk eyeklaasln earqelsdkv relsrsagkt slveeaekha rslqelakql
2101	eeikrnasgd elvrcavdaa tayenilnai kaaedaanra asasesalqt vikedlprka
2161	ktlssnsdkl lneakmtqkk lkqevspaln nlqqtinivt vqkevidtnl ttlrdglhgi
2221	qrgdidamis saksmvrkan ditdevldgl npiqtdveri kdtygrtqne dfkkaltdad
2281	nsvnkltnkl pdlwrkiesi nqqllplgni sdnmdrirel iqqardaask vavpmrfngk
2341	sgvevrlpnd ledlkgytsl slflqrpnsr enggtenmfv mylgnkdasr dyigmavvdg
2401	qltcvynlgd reaelqvdqi ltksetkeav mdrvkfqriy qfarlnytkg atsskpetpg
2461	vydmdgrnsn tllnldpenv vfyvggyppd fklpsrlsfp pykgcieldd lnenvlslyn
2521	fkktfnintt evepcrrrke esdknyfegt gyarvptqph apiptfgqti qttvdrgllf
2581	faengdrfis lniedgklmv ryklnselpk ergvgdainn grdhsiqiki gklqkrmwin
2641	vdvqntiidg evfdfstyyl ggipiairer fnistpafrg cmknlkktsg wvrindtvgv
2701	tkkcsedwkl vrsasfsrgg qlsftdlglp ptdhlqasfg fqtfqpsgil ldhqtwtrnl
2761	qvtledgyie lstsdsgspi fkspqtymdg llhyvsvisd nsglrllidd qllrnskrik
2821	hisssrqslr lggsnfegci snvfvqrlsl spevldltsn slkrdvslgg cslnkppflm
2881	llkgstrfnk tktfrinqll qdtpvasprs vkvwqdacsp lpktqanhga lqfgdiptsh
2941	llfklpqell kprsqfavdm qttssrglvf htgtknsfma lylskgrlvf algtdgkklr
3001	ikskekcndg kwhtvvfghd gekgrlvvdg lraregslpg nstisirapv ylgsppsgkp
3061	kslptnsfvg clknfqldsk plytpsssfg vssclggple kgiyfseegg hvvlahsvll
3121	gpefklvfsi rprsltgili higsqpgkhl cvyleagkvt asmdsgaggt stsvtpkqsl
3181	cdgqwhsvav tikqhilhle ldtdssytag qipfppastq eplhlggapa nlttlripvw
3241	ksffgclrni hvnhipvpvt ealevqgpvs lngcpdq

Protein sequence isoform 2 (SEQ ID NO (81)):

1	mppavrrsac smgwlwifga algqclgyss qqqrvpflqp pgqsqlqasy vefrpsqgcs
61	pgyyrdhkgl ytgrcvpcnc nghsnqcqdg sgicvncqhn tagehcercq egyygnavhg
121	scracpcpht nsfatgcvvn ggdvrcscka gytgtqcerc apgyfgnpqk fggscqpcsc
181	nsngqlgsch pltgdcinqe pkdsspaeec ddcdscvmtl lndlatmgeq lrlvksqlqg
241	lsasaglleq mrhmetqakd lrnqllnyrs aisnhgskie glereltdln qefetlqeka
301	qvnsrkaqtl nnnvnratqs akeldvkikn virnvhillk qisgtdgegn nvpsgdfsre
361	waeaqrmmre lrnrnfgkhl reaeadkres qlllnrirtw qkthqgenng lansirdsln
421	eyeaklsdlr arlqeaaaqa kqanglngen eralgaiqrq vkeinslqsd ftkylttads
481	sllqtnialq lmeksqkeye klaaslnear qelsdkvrel srsagktslv eeaekharsl
541	qelakqleei krnasgdelv rcavdaatay enilnaikaa edaanraasa sesalqtvik
601	edlprkaktl ssnsdkllne akmtqkklkq evspalnnlq qtlnivtvqk evidtnlttl
661	rdglhgiqrg didamissak smvrkandit devldglnpi qtdverikdt ygrtqnedfk
721	kaltdadnsv nkltnklpdl wrkiesinqq llplgnisdn mdrireliqq ardaaskvav
781	pmrfngksgv evripndled lkgytslslf lqrpnsreng gtenmfvmyl gnkdasrdyi
841	gmavvdgqlt cvynlgdrea elqvdqiltk setkeavmdr vkfqriyqfa rlnytkgats
901	skpetpgvyd mdgrnsntll nldpenvvfy vggyppdfkl psrlsfppyk gcielddlne
961	nvlslynfkk tfnlntteve pcrrrkeesd knyfegtgya rvptqphapi ptfgqtiqtt
1021	vdrgliffae ngdrfislni edgklmvryk lnselpkerg vgdainngrd hsiqikigkl
1081	qkrmwinvdv qntiidgevf dfstyylggi piairerfni stpafrgcmk nlkktsgvvr
1141	lndtvgvtkk csedwklvrs asfsrggqls ftdlglpptd hlqasfgfqt fqpsgilldh
1201	qtwtrnlqvt ledgyielst sdsgspifks pqtymdgllh yvsvisdnsg lrlliddqll
1261	rnskrikhis ssrqslrlgg snfegcisnv fvqrlslspe vldltsnslk rdvslggcsl
1321	nkppflmilk gstrfnktkt frinqllqdt pvasprsvkv wqdacsplpk tqanhgalqf
1381	gdiptshllf klpqellkpr sqfavdmqtt ssrglvfhtg tknsfmalyl skgrlvfalg
1441	tdgkklriks kekcndgkwh tvvfghdgek grlvvdglra regslpgnst isirapvylg
1501	sppsgkpksl ptnsfvgclk nfqldskply tpsssfgvss clggplekgi yfseegghvv
1561	lahsvllgpe fklvfsirpr sltgilihig sqpgkhlcvy leagkvtasm dsgaggtsts
1621	vtpkqslcdg qwhsvavtik qhilhleldt dssytagqip fppastqepl hlggapanlt
1681	tlripvwksf fgclrnihvn hipvpvteal evqgpvslng cpdq

Protein sequence isoform 4 (SEQ ID NO (82)):

1	mppavrrsac smgwlwifga algqclgyss qqqrvpflqp pgqsqlqasy vefrpsqgcs
61	pgyyrdhkgl ytgrcvpcnc nghsnqcqdg sgicvncqhn tagehcercq egyygnavhg
121	scracpcpht nsfatgcvvn ggdvrescka gytgtqcerc apgyfgnpqk fggscqpcsc
181	nsngqlgsch pltgdcinqe pkdsspaeec ddcdscvmtl lndlatmgeq lrlvksqlqg
241	lsasaglleq mrhmetqakd lrnqllnyrs aisnhgskie glereltdln qefetlqeka
301	qvnsrkaqtl nnnvnratqs akeldvkikn virnvhmlnr irtwqkthqg ennglansir
361	dslneyeakl sdlrarlqea aaqakqangl ngeneralga iqrqvkeins lqsdftkylt
421	tadssllqtn ialqlmeksq keyeklaasl nearqelsdk vrelsrsagk tslveeaekh
481	arslqelakq leeikrnasg delvrcavda atayenilna ikaaedaanr aasasesalq
541	tvikediprk aktlssnsdk llneakmtqk klkqevspal nnlqqtlniv tvqkevidtn
601	lttlrdglhg iqrgdidami ssaksmvrka nditdevldg lnpiqtdver ikdtygrtqn
661	edfkkaltda dnsvnkltnk lpdlwrkies inqqllplgn isdnmdrire liqqardaas
721	kvavpmrfng ksgvevripn dledlkgyts lslflqrpns renggtenmf vmylgnkdas
781	rdyigmavvd gqltcvynlg dreaelqvdq iltksetkea vmdrvkfqri yqfarlnytk
841	gatsskpetp gvydmdgrns ntlinldpen vvfyvggypp dfklpsrlsf ppykgcield
901	dlnenvisly nfkktfnint tevepcrrrk eesdknyfeg tgyarvptqp hapiptfgqt
961	iqttvdrgll ffaengdrfi slniedgklm vryklnselp kergvgdain ngrdhsiqik
1021	igklqkrmwi nvdvqntiid gevfdfstyy lggipiaire rfnistpafr gcmknlkkts
1081	gvvrindtvg vtkkcsedwk lvrsasfsrg gqlsftdlgl pptdhlqasf gfqtfqpsgi
1141	lldhqtwtrn lqvtledgyi elstsdsgsp ifkspqtymd gllhyvsvis dnsgirllid
1201	dqllrnskrl khisssrqsl riggsnfegc isnvfvqrls lspevidits nslkrdvslg
1261	gcslnkppfl mllkgstrfn ktktfrinql lqdtpvaspr svkvwqdacs plpktqanhg
1321	alqfgdipts hilfklpqel lkprsqfavd mqttssrglv fhtgtknsfm alylskgrlv
1381	falgtdgkkl rikskekcnd gkwhtvvfgh dgekgrlvvd glraregslp gnstisirap
1441	vylgsppsgk pkslptnsfv gclknfqlds kplytpsssf gvssclggpl ekgiyfseeg
1501	ghvvlahsvl lgpefklvfs irprsltgil ihigsqpgkh lcvyleagkv tasmdsgagg
1561	tstsvtpkqs lcdgqwhsva vtikqhilhl eldtdssyta gqipfppast qeplhlggap
1621	anlttlripv wksffgclrn ihvnhipvpv tealevqgpv slngcpdq
Gene ID:	Y16
Gene symbol:	CD40
Gene description:	CD40 molecule
Unigene:	Hs.472860
Genbank:	AB209660
Entrez Gene:	958
Refseq:	NM_001250|NM_152854

Protein sequence isoform 1 (SEQ ID NO (83)):

1	mvrlplqcvl wgclltavhp epptacrekq ylinsqccsl cqpgqklvsd cteftetecl
61	pcgesefldt wnrethchqh kycdpnlglr vqqkgtsetd tictceegwh ctseacescv
121	lhrscspgfg vkqiatgvsd ticepcpvgf fsnvssafek chpwtscetk dlvvqqagtn
181	ktdvvcgpqd rlralvvipi ifgilfaill vlvfikkvak kptnkaphpk qepqeinfpd
241	dlpgsntaap vqetlhgcqp vtqedgkesr isvqerq

Protein sequence isoform 2 (SEQ ID NO (84)):

1	mvrlplqcvl wgclltavhp epptacrekq ylinsqccsl cqpgqklvsd cteftetecl
61	pcgesefldt wnrethchqh kycdpnlglr vqqkgtsetd tictceegwh ctseacescv
121	lhrscspgfg vkqiatgvsd ticepcpvgf fsnvssafek chpwtrspgs aespggdphh
181	lrdpvchplg aglyqkggqe anq
Gene ID:	Y17
Gene symbol:	COL17A1
Gene description:	collagen, type XVII, alpha 1
Unigene:	Hs.117938
Genbank:	AL138761
Entrez Gene:	1308
Refseq:	NM_000494

Protein sequence (SEQ ID NO (85)):

1	mdvtkknkrd gtevterivt etvttrltsl ppkggtsngy aktaslgggs rlekqslthg
61	ssgyinstgs trghastssy rrahspastl pnspgstfer kthvtrhaye gsssgnsspe
121	yprkefasss trgrsqtres eirvrlqsas pstrwteldd vkrllkgsrs asvsptrnss
181	ntlpipkkgt vetkivtass qsvsgtydat ildanlpshv wsstlpagss mgtyhnnmtt
241	qsssllntna ysagsvfgvp nnmascsptl hpglstsssv fgmqnnlaps lttlshgttt
301	tstaygvkkn mpqspaavnt gvstsaactt svqsddllhk dckflilekd ntpakkemel
361	limtkdsgkv ftaspasiaa tsfsedtikk ekqaaynads glkaeangdl ktvstkgktt
421	tadihsygss ggggsggggg vggagggpwg papawcpcgs ccswwkwllg llltwilllg
481	llfglialae evrklkarvd elerirrsil pygdsmdrie kdrlqgmapa agadldkigl
541	hsdsqeelwm fvrkkimmeq engnirgspg pkgdmgspgp kgdrgfpgtp gipgplghpg
601	pqgpkgqkgs vgdpgmegpm gqrgregpmg prgeagppgs gekgergaag epgphgppgv
661	pgsvgpkgss gspgpqgppg pvglqgirge vglpgvkgdk gpmgppgpkg dqgekgprgl
721	tgepgmrglp gavgepgakg amgpagpdgh qgprgeqglt gmpgirgppg psgdpgkpgl
781	tgpqgpqglp gtpgrpgikg epgapgkivt segssmltvp gppgppgamg ppgppgapgp
841	agpaglpghq eviniqgppg ppgprgppgp sipgppgprg ppgeglpgpp gppgsflsns
901	etflsgppgp pgppgpkgdq gppgprghqg eqglpgfsts gsssfginiq gppgppgpqg
961	pkgdkgdpgv pgalgipsgp seggssstmy vsgppgppgp pgppgsisss gqeiqqyise
1021	ymqsdsirsy lsgvqgppgp pgppgpvtti tgetfdysel ashvvsylrt sgygvslfss
1081	sissedilav lqrddvrqyl rqylmgprgp pgppgasgdg sllsldyael ssrilsymss
1141	sgisiglpgp pgppglpgts yeellsllrg sefrgivgpp gppgppgipg nvwssisved
1201	lssylhtagl sfipgppgpp gppgprgppg vsgalatyaa ensdsfrsel isyltspdvr
1261	sfivgppgpp gpqgppgdsr llstdashsr gssssshsss vrrgssysss mstggggags
1321	lgaggafgea agdrgpygtd igpgggygaa aeggmyagng gllgadfagd ldynelavrv
1381	sesmqrqgll qgmaytvqgp pgqpgpqgpp giskvfsays nvtadlmdff qtygaiqgpp
1441	gqkgemgtpg pkgdrgpagp pghpgppgpr ghkgekgdkg dqvyagrrrr rsiavkp
Gene ID:	Y18
Gene symbol:	DSC2
Gene description:	Desmocollin-2
Unigene:	Hs.95612
Genbank:	BC063291
Entrez Gene:	1824
Refseq:	NM_024422|NM_004949

Protein sequence isoform Dsc2a (SEQ ID NO (86)):

1	meaarpsgsw ngalcrllll tlailifasd acknvtlhvp skldaeklvg rvnlkecfta
61	anlihssdpd fqiledgsvy ttntillsse krsftillsn tenqekkkif vflehqtkvl
121	kkrhtkekvl rrakrrwapi pcsmlenslg pfplflqqvq sdtaqnytiy ysirgpgvdq
181	eprnlfyver dtgnlyctrp vdreqyesfe iiafattpdg ytpelplpli ikiedendny
241	pifteetytf tifencrvgt tvgqvcatdk depdtmhtrl kysiigqvpp sptlfsmhpt
301	tgvitttssq ldrelidkyq lkikvqdmdg qyfglqttst ciiniddvnd hlptftrtsy
361	vtsveentvd veilrvtved kdlvntanwr anytilkgne ngnfkivtda ktnegvlcvv
421	kplnyeekqq milqigvvne apfsreaspr samstatvtv nvedqdegpe cnppiqtvrm
481	kenaevgtts ngykaydpet rsssgirykk ltdptgwvti dentgsikvf rsldreaeti
541	kngiynitvl asdqggrtct gtlgiilqdv ndnspfipkk tviickptms saeivavdpd
601	epihgppfdf slesstsevq rmwrlkaind taarlsyqnd ppfgsyvvpi tvrdrlgmss
661	vtsldvtlcd citendcthr vdpriggggv qlgkwailai llgiallfci lftlvcgasg
721	tskqpkvipd dlaqqnlivs nteapgddkv ysangfttqt vgasaqgvcg tvgsgikngg
781	qetiemvkgg hqtsescrga ghhhtldscr gghtevdncr ytysewhsft qprlgekvyl
841	cnqdenhkha qdyvltynye grgsvagsvg ccserqeedg lefldnlepk frtlaeacmk
901	r

Protein sequence isoform Dsc2b (SEQ ID NO (87)):

1	meaarpsgsw ngalcrllll tlailifasd acknvtlhvp skldaeklvg rvnlkecfta
61	anlihssdpd fqiledgsvy ttntillsse krsftillsn tenqekkkif vflehqtkvl
121	kkrhtkekvl rrakrrwapi pcsmlenslg pfplflqqvq sdtaqnytiy ysirgpgvdq
181	eprnlfyver dtgnlyctrp vdreqyesfe iiafattpdg ytpelplpli ikiedendny
241	pifteetytf tifencrvgt tvgqvcatdk depdtmhtrl kysiigqvpp sptlfsmhpt
301	tgvitttssq ldrelidkyq lkikvqdmdg qyfglqttst ciiniddvnd hlptftrtsy
361	vtsveentvd veilrvtved kdlvntanwr anytilkgne ngnfkivtda ktnegvlcwv
421	kplnyeekqq milqigvvne apfsreaspr samstatvtv nvedqdegpe cnppiqtvrm
481	kenaevgtts ngykaydpet rsssgirykk ltdptgwvti dentgsikvf rsldreaeti
541	kngiynitvl asdqggrtct gtlgiilqdv ndnspfipkk tviickptms saeivavdpd
601	epihgppfdf slesstsevq rmwrlkaind taarlsyqnd ppfgsyvvpi tvrdilgmss
661	vtsldvtlcd citendcthr vdpriggggv qlgkwailai llgiallfci lftlvcgasg
721	tskqpkvipd dlaqqnlivs nteapgddkv ysangfttqt vgasaqgvcg tvgsgikngg
781	qetiemvkgg hqtsescrga ghhhtldscr gghtevdncr ytysewhsft qprlgeesir
841	ghtlikn
Gene ID:	Y19
Gene symbol:	DSC1
Gene description:	Desmocollin-1
Unigene:	Hs.567260
Genbank:	X72925
Entrez Gene:	1823
Refseq:	NM_024421|NM_004948

Protein sequence isoform Dsc1a (SEQ ID NO (88)):

1	malasaapgs ifckqllfsl lvltllcdac qkvylrvpsh lqaetlvgkv nleeclksas
61	lirssdpafr iledgsiytt hdlilsserk sfsiflsdgq rreqqeikvv lsarenkspk
121	krhtkdtalk rskrrwapip aslmenslgp fpqhvqqiqs daaqnytify sisgpgvdke
181	pfnlfyiekd tgdifctrsi drekyeqfal ygyattadgy apeyplplii kieddndnap
241	yfehrvtift vpencrsgts vgkvtatdld epdtlhtrlk ykilqqipdh pkhfsihpdt
301	gvittttpfl drekcdtyql imevrdmggq pfglfntgti tisledendn ppsftetsyv
361	teveenridv eilrmkvqdq dlpntphska vykilqgnen gnfiistdpn tnegvlcvvk
421	plnyevnrqv ilqvgvinea qfskaassqt ptmctttvtv kiidsdegpe chppvkviqs
481	qdgfpagqel lgykaldpei ssgeglryqk lgdednwfei nqhtgdlrtl kvldreskfv
541	knnqynisvv avdavgrsct gtlvvhlddy ndhapqidke vticqnnedf avlkpvdpdg
601	pengppfqff ldnsasknwn ieekdgktai lrqrqnldyn yysvpiqikd rhglvathml
661	tvrvcdcstp secrmkdkst rdvrpnvilg rwailamvig svlllcilft cfcvtakrtv
721	kkcfpediaq qnlivsnteg pgeevteani rlpmqtsnic dtsmsvgtvg gqgiktqqsf
781	emvkggytld snkggghqtl esvkgvgqgd tgryaytdwq sftqprigek vylcgqdeeh
841	khcedyvcsy nyegkgslag svgccsdrqe eeglefldhl epkfrtlakt cikk

Protein sequence isoform Dsc1b (SEQ ID NO (89)):

1	malasaapgs ifckqllfsl lvltllcdac qkvylrvpsh lqaetlvgkv nleeclksas
61	lirssdpafr iledgsiytt hdlilsserk sfsiflsdgq rreqqeikvv lsarenkspk
121	krhtkdtalk rskrrwapip aslmenslgp fpqhvqqiqs daaqnytify sisgpgvdke
181	pfnlfyiekd tgdifctrsi drekyeqfal ygyattadgy apeyplplii kieddndnap
241	yfehrvtift vpencrsgts vgkvtatdld epdtlhtrik ykilqqipdh pkhfsihpdt
301	gvittttpfl drekcdtyql imevrdmggq pfglfntgti tisledendn ppsftetsyv
361	teveenridv eilrmkvqdq dlpntphska vykilqgnen gnfiistdpn tnegvlcvvk
421	plnyevnrqv ilqvgvinea qfskaassqt ptmctttvtv kiidsdegpe chppvkviqs
481	qdgfpagqel lgykaldpei ssgeglryqk lgdednwfei nqhtgdirtl kvldreskfv
541	knnqynisvv avdavgrsct gtlvvhiddy ndhapqidke vticqnnedf avlkpvdpdg
601	pengppfqff ldnsasknwn ieekdgktai lrqrqnldyn yysvpiqikd rhglvathml
661	tvrvcdcstp secrmkdkst rdvrpnvilg rwailamvlg svlllcilft cfcvtakrtv
721	kkcfpediaq qnlivsnteg pgeevteani rlpmqtsnic dtsmsvgtvg gqgiktqqsf
781	emvkggytld snkggghqtl esvkgvgqgd tgryaytdwq sftqprlgee sirghtlikn
Gene ID:	Y20
Gene symbol:	ITGA6
Gene description:	Integrin alpha-6
Unigene:	Hs.133397
Genbank:	X59512
Entrez Gene:	3655
Refseq:	NM_000210|NM_001079818

Protein sequence isoform b (SEQ ID NO (90)):

1	maaagqlcll ylsagllsrl gaafnldtre dnvirkygdp gslfgfslam hwqlqpedkr
61	lllvgaprae alplqranrt gglyscdita rgpctriefd ndadptsesk edqwmgvtvq
121	sqgpggkvvt cahryekrqh vntkqesrdi fgrcyvlsqn lrieddmdgg dwsfcdgrlr
181	ghekfgscqq gvaatftkdf hyivfgapgt ynwkgivrve qknntffdmn ifedgpyevg
241	getehdeslv pvpansylgf sldsgkgivs kdeitfvsga pranhsgavv llkrdmksah
301	llpehifdge glassfgydv avvdinkdgw qdivigapqy fdrdgevgga vyvymnqqgr
361	wnnvkpirln gtkdsmfgia vknigdinqd gypdiavgap yddlgkvfiy hgsangintk
421	ptqvlkgisp yfgysiagnm dldrnsypdv avgslsdsvt ifrsrpvini qktitvtpnr
481	idlrqktacg apsgiclqvk scfeytanpa gynpsisivg tleaekerrk sglssrvqfr
541	nqgsepkytq eltlkrqkqk vcmeetlwlq dnirdklrpi pitasveiqe pssrrrvnsl
601	pevlpilnsd epktahidvh flkegcgddn vcnsnlkley kfctregnqd kfsylpiqkg
661	vpelvikdqk dialeitvtn spsnprnptk dgddaheakl iatfpdtlty sayrelrafp
721	ekqlscvanq ngsqadcelg npfkrnsnvt fylvisttev tfdtpdldin lklettsnqd
781	nlapitakak vvielllsvs gvakpsqvyf ggtvvgeqam ksedevgsli eyefrvinlg
841	kpltnlgtat lniqwpkeis ngkwllylvk veskglekvt cepqkeinsl nlteshnsrk
901	kreitekqid dnrkfslfae rkyqtlncsv nvncvnircp lrgldskasl ilrsrlwnst
961	fleeysklny ldilmrafid vtaaaenirl pnagtqvrvt vfpsktvagy sgvpwwiilv
1021	ailagilmla llvfilwkcg ffkrnkkdhy datyhkaeih aqpsdkerlt sda

Protein sequence isoform a (SEQ ID NO (91)):

1	maaagqlcll ylsagllsrl gaafnldtre dnvirkygdp gslfgfslam hwqlqpedkr
61	lllvgaprae alplqranrt gglyscdita rgpctriefd ndadptsesk edqwmgvtvq
121	sqgpggkvvt cahryekrqh vntkqesrdi fgrcyvlsqn lrieddmdgg dwsfcdgnlr
181	ghekfgscqq gvaatftkdf hyivfgapgt ynwkgivrve qknntffdmn ifedgpyevg
241	getehdeslv pvpansylgf sldsgkgivs kdeitfvsga pranhsgavv llkrdmksah
301	llpehifdge glassfgydv avvdlnkdgw qdivigapqy fdrdgevgga vyvymnqqgr
361	wnnvkpirln gtkdsmfgia vknigdinqd gypdiavgap yddlgkvfiy hgsangintk
421	ptqvlkgisp yfgysiagnm dldrnsypdv avgslsdsvt ifrsrpvini qktitvtpnr
481	idlrqktacg apsgiclqvk scfeytanpa gynpsisivg tleaekerrk sglssrvqfr
541	nqgsepkytq eltlkrqkqk vcmeetlwlq dnirdkirpi pitasveiqe pssrrrvnsl
601	pevlpilnsd epktahidvh flkegcgddn vcnsnlkley kfctregnqd kfsylpiqkg
661	vpelvikdqk dialeitvtn spsnprnptk dgddaheakl iatfpdtlty sayrelrafp
721	ekqlscvanq ngsqadcelg npfkrnsnvt fylvlsttev tfdtpdldin lklettsnqd
781	nlapitakak vvielllsvs gvakpsqvyf ggtvvgeqam ksedevgsli eyefrvinlg
841	kpltnigtat lniqwpkeis ngkwllylvk veskglekvt cepqkeinsl nlteshnsrk
901	kreitekqid dnrkfslfae rkyqtlncsv nvncvnircp lrgldskasl ilrsrlwnst
961	fleeysklny ldilmrafid vtaaaenirl pnagtqvrvt vfpsktvagy sgvpwwiilv
1021	ailagilmla llvfilwkcg ffkrsrydds vpryhavrir keereikdek yidnlekkqw
1081	itkwnenesy s
Gene ID:	Y21
Gene symbol:	ITGB4
Gene description:	Integrin beta-4
Unigene:	Hs.632226
Genbank:	X53587|X51841|X52186
Entrez Gene:	3691
Refseq:	NM_000213|NM_001005619|NM_001005731

Protein sequence isoform 1 (SEQ ID NO (92)):

1	magprpspwa rlllaalisv slsgtlanrc kkapvkscte cvrvdkdcay ctdemfrdrr
61	cntqaellaa gcqresivvm essfqiteet qidttlrrsq mspqglrvrl rpgeerhfel
121	evfeplespv dlyilmdfsn smsddldnik kmgqnlarvl sqltsdytig fgkfvdkvsv
181	pqtdmrpekl kepwpnsdpp fsfknvisit edvdefrnkl qgerisgnld apeggfdail
241	qtavctrdig wrpdsthllv fstesafhye adganvlagi msrnderchl dttgtytqyr
301	tqdypsvptl vrllakhnii pifavtnysy syyeklhtyf pvsslgvlqe dssnivelle
361	eafnrirsnl diraldsprg lrtevtskmf qktrtgsfhi rrgevgiyqv qlralehvdg
421	thvcqlpedq kgnihlkpsf sdglkmdagi icdvctcelq kevrsarcsf ngdfvegqcv
481	csegwsgqtc ncstgslsdi qpclregedk pcsgrgecqc ghcvcygegr yegqfceydn
541	fqcprtsgfl cndrgresmg qcvcepgwtg pscdcplsna tcidsnggic ngrghcecgr
601	chchqqslyt dticeinysa ihpglcedlr scvqcqawgt gekkgrtcee cnfkvkmvde
661	lkraeevvvr csfrdedddc tysytmegdg apgpnstvlv hkkkdcppgs fwwlipllll
721	llpllallll lcwkycacck aclallpccn rghmvgfked hymlrenlma sdhldtpmlr
781	sgnlkgrdvv rwkvtnnmqr pgfathaasi nptelvpygl slrlarlcte nllkpdtrec
841	aqlrqeveen lnevyrqisg vhklqqtkfr qqpnagkkqd htivdtvlma prsakpallk
901	ltekqveqra fhdlkvapgy ytltadqdar gmvefqegve lvdvrvplfi rpedddekql
961	lveaidvpag tatlgrrlvn itiikeqard vvsfeqpefs vsrgdqvari pvirrvldgg
1021	ksqvsyrtqd gtaqgnrdyi pvegellfqp geawkelqvk llelqevdsl lrgrqvrrfh
1081	vqlsnpkfga hlgqphstti iirdpdeldr sftsqmlssq ppphgdlgap qnpnakaags
1141	rkihfnwlpp sgkpmgyrvk ywiqgdsese ahlldskvps veltnlypyc dyemkvcayg
1201	aqgegpyssl vscrthqevp sepgrlafnv vsstvtqlsw aepaetngei tayevcyglv
1261	nddnrpigpm kkvlvdnpkn rmllienlre sqpyrytvka rngagwgper eaiinlatqp
1321	krpmsipiip dipivdaqsg edydsflmys ddvirspsgs qrpsvsddtg cgwkfepllg
1381	eeldlrrvtw rlppeliprl sassgrssda eaphgppddg gaggkggslp rsatpgppge
1441	hlvngrmdfa fpgstnslhr mtttsaaayg thlsphvphr vlstsstltr dynsltrseh
1501	shsttlprdy stltsvsshd srltagvpdt ptrlvfsalg ptslrvswqe prcerplqgy
1561	sveyqllngg elhrlnipnp aqtsvvvedl lpnhsyvfrv raqsqegwgr eregvities
1621	qvhpqsplcp lpgsaftlst psapgplvft alspdslqls werprrpngd ivgylvtcem
1681	aqgggpataf rvdgdspesr ltvpglsenv pykfkvqart tegfgpereg iitiesqdgg
1741	pfpqlgsrag lfqhplqsey ssittthtsa tepflvdglt lgaqhleagg sltrhvtqef
1801	vsrtlttsgt lsthmdqqff qt

Protein sequence isoform 2 (SEQ ID NO (93)):

1	magprpspwa rlllaalisv slsgtlanrc kkapvkscte cvrvdkdcay ctdemfrdrr
61	cntqaellaa gcqresivvm essfqiteet qidttlrrsq mspqglrvrl rpgeerhfel
121	evfeplespv dlyilmdfsn smsddldnik kmgqnlarvl sqltsdytig fgkfvdkvsv
181	pqtdmrpekl kepwpnsdpp fsfknvisit edvdefrnkl qgerisgnld apeggfdail
241	qtavctrdig wrpdsthllv fstesafhye adganvlagi msrnderchl dttgtytqyr
301	tqdypsvptl vrllakhnii pifavtnysy syyeklhtyf pvsslgvlqe dssnivelle
361	eafnrirsnl diraldsprg lrtevtskmf qktrtgsfhi rrgevgiyqv qlralehvdg
421	thvcqlpedq kgnihlkpsf sdglkmdagi icdvctcelq kevrsarcsf ngdfvcgqcv
481	csegwsgqtc ncstgslsdi qpclregedk pcsgrgecqc ghcvcygegr yegqfceydn
541	fqcprtsgfl cndrgresmg qcvcepgwtg pscdcplsna tcidsnggic ngrghcecgr
601	chchqqslyt dticeinysa ihpglcedir scvqcqawgt gekkgrtcee cnfkvkmvde
661	lkraeevvvr csfrdedddc tysytmegdg apgpnstvlv hkkkdcppgs fwwlipllll
721	llpllallll lcwkycacck aclallpccn rghmvgfked hymlrenlma sdhldtpmlr
781	sgnlkgrdvv rwkvtnnmqr pgfathaasi nptelvpygl sirlaricte nllkpdtrec
841	aqlrqeveen lnevyrqisg vhklqqtkfr qqpnagkkqd htivdtvlma prsakpallk
901	ltekqveqra fhdlkvapgy ytltadqdar gmvefqegve lvdvrvplfi rpedddekql
961	lveaidvpag tatlgrrlvn itiikeqard vvsfeqpefs vsrgdqvari pvirrvldgg
1021	ksqvsyrtqd gtaqgnrdyi pvegellfqp geawkelqvk llelqevdsl lrgrqvrrfh
1081	vqlsnpkfga hlgqphstti iirdpdeldr sftsqmissq ppphgdlgap qnpnakaags
1141	rkihfnwlpp sgkpmgyrvk ywiqgdsese ahlldskvps veltnlypyc dyemkvcayg
1201	aqgegpyssl vscrthqevp sepgrlafnv vsstvtqlsw aepaetngei tayevcyglv
1261	nddnrpigpm kkvlvdnpkn rmllienlre sqpyrytvka rngagwgper eaiinlatqp
1321	krpmsipiip dipivdaqsg edydsflmys ddvlrspsgs qrpsvsddte hlvngrmdfa
1381	fpgstnslhr mtttsaaayg thisphvphr vistsstltr dynsltrseh shsttlprdy
1441	stltsvsshg lppiwehgrs rlplswalgs rsraqmkgfp psrgprdsii lagrpaapsw
1501	gpdsrltagv pdtptrlvfs algptsirvs wqeprcerpl qgysveyqll nggelhrlni
1561	pnpaqtsvvv edllpnhsyv frvraqsqeg wgreregvit iesqvhpqsp lcplpgsaft
1621	lstpsapgpl vftalspdsl qlswerprrp ngdivgylvt cemaqgggpa tafrvdgdsp
1681	esrltvpgls envpykfkvq arttegfgpe regiitiesq dggpfpqlgs raglfqhplq
1741	seyssittth tsatepflvd gltlgaqhle aggsltrhvt qefvsrtltt sgtlsthmdq
1801	qffqt

Protein sequence isoform 3 (SEQ ID NO (94)):

1	magprpspwa rlllaalisv slsgtlanrc kkapvkscte cvrvdkdcay ctdemfrdrr
61	cntqaellaa gcqresivvm essfqiteet qidttlrrsq mspqglrvrl rpgeerhfel
121	evfeplespv dlyilmdfsn smsddldnlk kmgqnlarvl sqltsdytig fgkfvdkvsv
181	pqtdmrpekl kepwpnsdpp fsfknvislt edvdefrnkl qgerisgnld apeggfdail
241	qtavctrdig wrpdsthllv fstesafhye adganvlagi msrnderchl dttgtytqyr
301	tqdypsvptl vrllakhnii pifavtnysy syyeklhtyf pvsslgvlqe dssnivelle
361	eafnrirsnl diraldsprg lrtevtskmf qktrtgsfhi rrgevgiyqv qlralehvdg
421	thvcqlpedq kgnihlkpsf sdglkmdagi icdvctcelq kevrsarcsf ngdfvcgqcv
481	csegwsgqtc ncstgslsdi qpclregedk pcsgrgecqc ghcvcygegr yegqfceydn
541	fqcprtsgfl cndrgresmg qcvcepgwtg pscdcplsna tcidsnggic ngrghcecgr
601	chchqqslyt dticeinysa ihpglcedir scvqcqawgt gekkgrtcee cnfkvkmvde
661	lkraeevvvr csfrdedddc tysytmegdg apgpnstvlv hkkkdcppgs fwwlipllll
721	llpllallll lcwkycacck aclallpccn rghmvgfked hymlrenlma sdhldtpmlr
781	sgnlkgrdvv rwkvtnnmqr pgfathaasi nptelvpygl slrlarlcte nllkpdtrec
841	aqlrqeveen lnevyrqisg vhklqqtkfr qqpnagkkqd htivdtvlma prsakpallk
901	ltekqveqra fhdlkvapgy ytltadqdar gmvefqegve lvdvrvplfi rpedddekql
961	lveaidvpag tatlgrrlvn itiikeqard vvsfeqpefs vsrgdqvari pvirrvldgg
1021	ksqvsyrtqd gtaqgnrdyi pvegellfqp geawkelqvk llelqevdsl lrgrqvrrfh
1081	vqlsnpkfga hlgqphstti iirdpdeldr sftsqmlssq ppphgdlgap qnpnakaags
1141	rkihfnwlpp sgkpmgyrvk ywiqgdsese ahlldskvps veltnlypyc dyemkvcayg
1201	aqgegpyssl vscrthqevp sepgrlafnv vsstvtqlsw aepaetngei tayevcyglv
1261	nddnrpigpm kkvlvdnpkn rmllienlre sqpyrytvka rngagwgper eaiinlatqp
1321	krpmsipiip dipivdaqsg edydsflmys ddvlrspsgs qrpsvsddte hlvngrmdfa
1381	fpgstnslhr mtttsaaayg thlsphvphr vlstsstltr dynsltrseh shsttlprdy
1441	stltsvsshd srltagvpdt ptrlvfsalg ptslrvswqe prcerplqgy sveyqllngg
1501	elhrlnipnp aqtsvvvedl lpnhsyvfrv raqsqegwgr eregvities qvhpqsplcp
1561	lpgsaftlst psapgplvft alspdslqls werprrpngd ivgylvtcem aqgggpataf
1621	rvdgdspesr ltvpglsenv pykfkvqart tegfgpereg iitiesqdgg pfpqlgsrag
1681	lfqhplqsey ssittthtsa tepflvdglt lgaqhleagg sltrhvtqef vsrtlttsgt
1741	lsthmdqqff qt
Gene ID:	Y22
Gene symbol:	PVRL4
Gene description:	Poliovirus receptor-related protein 4
Unigene:	Hs.492490
Genbank:	BC010423
Entrez Gene:	81607
Refseq:	NM_030916

Protein sequence (SEQ ID NO (95)):

1	mplslgaemw gpeawlllll llasftgrcp ageletsdvv tvvlgqdakl pcfyrgdsge
61	qvgqvawarv dagegaqela llhskyglhv spayegrveq pppprnpldg svllrnavqa
121	degeyecrvs tfpagsfqar lrlrvlvppl pslnpgpale egqgltlaas ctaegspaps
181	vtwdtevkgt tssrsfkhsr saavtsefhl vpsrsmngqp ltcvvshpgl lqdqrithil
241	hvsflaeasv rgledqnlwh igregamlkc lsegqpppsy nwtrldgplp sgvrvdgdtl
301	gfpplttehs giyvchvsne fssrdsqvtv dvldpqedsg kqvdlvsasv vvvgviaall
361	fcllvvvvvl msryhrrkaq qmtqkyeeel tltrensirr lhshhtdprs qpeesvglra
421	eghpdslkdn sscsvmseep egrsystltt vreietqtel lspgsgraee eedqdegikq
481	amnhfvqeng tlrakptgng iyingrghlv
Gene ID:	Y23
Gene symbol:	SDC1
Gene description:	Syndecan-1
Unigene:	Hs.224607
Genbank:	BC008765
Entrez Gene:	6382
Refseq:	NM_001006946

Protein sequence (SEQ ID NO (96)):

1	mrraalwlwl calalslqpa lpqivatnlp pedqdgsgdd sdnfsgsgag alqditlsqq
61	tpstwkdtql ltaiptspep tgleataast stlpagegpk egeavvlpev epgltareqe
121	atprprettq lptthqastt tattaqepat shphrdmqpg hhetstpagp sqadlhtpht
181	edggpsater aaedgassql paaegsgeqd ftfetsgent avvavepdrr nqspvdqgat
241	gasqglldrk evlggviagg lvglifavcl vgfmlyrmkk kdegsyslee pkqanggayq
301	kptkqeefya
Gene ID:	Z1
Gene symbol:	ENPP1
Gene description:	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Unigene:	Hs.527295
Genbank:	BC059375
Entrez Gene:	5167
Refseq:	NM_006208

Protein sequence (SEQ ID NO (97)):

1	merdgcaggg srggeggrap regpagngrd rgrshaaeap gdpqaaasll apmdvgeepl
61	ekaarartak dpntykvlsl vlsvcvltti lgcifglkps cakevksckg rcfertfgnc
121	rcdaacvelg nccldyqetc iepehiwten kfrcgekrlt rslcacsddc kdkgdcciny
181	ssvcqgeksw veepcesine pqcpagfetp ptllfsldgf raeylhtwgg llpvisklkk
241	cgtytknmrp vyptktfpnh ysivtglype shgiidnkmy dpkmnasfsl kskekfnpew
301	ykgepiwvta kyqglksgtf fwpgsdvein gifpdiykmy ngsvpfeeri lavlqwlqlp
361	kderphfytl yleepdssgh sygpvssevi kalqrvdgmv gmlmdglkel nlhrclnlil
421	isdhgmeqgs ckkyiylnky lgdvknikvi ygpaarlrps dvpdkyysfn yegiarnlsc
481	repnqhfkpy lkhflpkrlh faksdriepl tfyldpqwql alnpserkyc gsgfhgsdnv
541	fsnmqalfvg ygpgfkhgie adtfenievy nlmcdllnlt papnngthgs lnhllknpvy
601	tpkhpkevhp lvqcpftrnp rdnlgcscnp silpiedfqt qfnltvaeek iikhetlpyg
661	rprvlqkent icllsqhqfm sgysqdilmp lwtsytvdrn dsfstedfsn clyqdfripl
721	spvhkcsfyk nntkvsygfl sppqlnknss giysealltt nivpmyqsfq viwryfhdtl
781	lrkyaeerng vnvvsgpvfd fdydgrcdsl enlrqkrrvi rnqeilipth ffivltsckd
841	tsqtplhcen ldtlafilph rtdnsescvh gkhdsswvee llmlhrarit dvehitglsf
901	yqqrkepvsd ilklkthlpt fsqed
Gene ID:	Z2
Gene symbol:	CD34
Gene description:	Hematopoietic progenitor cell antigen CD34
Unigene:	Hs.374990
Genbank:	M81104
Entrez Gene:	947
Refseq:	NM_001773|NM_001025109

Protein sequence isoform b (SEQ ID NO (98)):

1	mlvrrgarag prmprgwtal cllsllpsgf msldnngtat pelptqgtfs nvstnvsyqe
61	tttpstlgst slhpvsqhgn eattnitett vkftstsvit svygntnssv qsqtsvistv
121	fttpanvstp ettlkpslsp gnvsdlstts tslatsptkp ytssspilsd ikaeikcsgi
181	revkltqgic leqnktssca efkkdrgegl arvlcgeeqa dadagaqvcs lllaqsevrp
241	qclllvlanr teissklqlm kkhqsdlkkl gildfteqdv ashqsysqkt lialvtsgal
301	lavlgitgyf lmnrrswspt gerlelep

Protein sequence isoform a (SEQ ID NO (99)):

1	mlvrrgarag prmprgwtal cllsllpsgf msldnngtat pelptqgtfs nvstnvsyqe
61	tttpstlgst slhpvsqhgn eattnitett vkftstsvit svygntnssv qsqtsvistv
121	fttpanvstp ettlkpslsp gnvsdlstts tslatsptkp ytssspilsd ikaeikcsgi
181	revkltqgic leqnktssca efkkdrgegl arvlcgeeqa dadagaqvcs lllaqsevrp
241	qclllvlanr teissklqlm kkhqsdlkkl gildfteqdv ashqsysqkt lialvtsgal
301	lavlgitgyf lmnrrswspt gerlgedpyy tengggqgys sgpgtspeaq gkasvnrgaq
361	engtgqatsr nghsarqhvv adtel
Gene ID:	Z3
Gene symbol:	JAM3
Gene description:	Junctional adhesion molecule C
Unigene:	Hs.150718
Genbank:	BC012147
Entrez Gene:	83700
Refseq:	NM_032801|NM_001205329

Protein sequence isoform 1 (SEQ ID NO (100)):

1	malrrpprlr lcarlpdffl lllfrgclig avnlkssnrt pvvqefesve lsciitdsqt
61	sdpriewkki qdeqttyvff dnkiqgdlag raeilgktsl kiwnvtrrds alyrcevvar
121	ndrkeideiv ieltvqvkpv tpvcrvpkav pvgkmatlhc qeseghprph yswyrndvpl
181	ptdsranprf rnssfhlnse tgtlvftavh kddsgqyyci asndagsarc eeqemevydl
241	niggiiggvl vvlavlalit lgiccayrrg yfinnkqdge syknpgkpdg vnyirtdeeg
301	dfrhkssfvi

Protein sequence isoform 2 (SEQ ID NO (101)):

1	malrrpprlr lcarlpdffl lllfrgclig avnlkssnrt pvvqefesve lsciitdsqt
61	sdpriewkki qdeqttyvff dnkiqvkpvt pvcrvpkavp vgkmatlhcq eseghprphy
121	swyrndvplp tdsranprfr nssfhlnset gtlvftavhk ddsgqyycia sndagsarce
181	eqemevydln iggiiggvlv vlavlalitl giccayrrgy finnkqdges yknpgkpdgv
241	nyirtdeegd frhkssfvi
Gene ID:	Z4
Gene symbol:	CD14
Gene description:	Monocyte differentiation antigen CD14
Unigene:	Hs.163867
Genbank:	BC010507
Entrez Gene:	929
Refseq:	NM_000591

Protein sequence (SEQ ID NO (102)):

1	merascllll llplvhvsat tpepceldde dfrcvcnfse pqpdwseafq cvsaveveih
61	agglnlepfl krvdadadpr qyadtvkalr vrrltvgaaq vpaqllvgal rvlaysrlke
121	ltledlkitg tmpplpleat glalsslrlr nvswatgrsw laelqqwlkp glkvlsiaqa
181	hspafsceqv rafpaltsld lsdnpglger glmaalcphk fpaiqnlalr ntgmetptgv
241	caalaaagvq phsldlshns lratvnpsap rcmwssalns lnlsfagleq vpkglpaklr
301	vldlscnrln rapqpdelpe vdnltldgnp flvpgtalph egsmnsgvvp acarstlsvg
361	vsgtlvllqg argfa
Gene ID:	Z5
Gene symbol:	PLSCR4
Gene description:	Phospholipid scramblase 4
Unigene:	Hs.477869
Genbank:	AF199023
Entrez Gene:	57088
Refseq:	NM_001128304|NM_001128306|NM_001177304

Protein sequence isoform a (SEQ ID NO (103)):

1	msgvvptape qpagemenqt kppdprpdap peynshflpg ppgtavpppt gypgglpmgy
61	yspqqpstfp lyqpvggihp vryqpgkypm pnqsvpitwm pgptpmancp pgleylvqld
121	nihvlqhfep lemmtcfetn nrydiknnsd qmvyivtedt ddftrnayrt lrpfvlrvtd
181	cmgreimtmq rpfrctcccf ccpsarqele vqcppgvtig fvaehwnlcr avysiqnekk
241	envmrvrgpc stygcgsdsv fevksldgis nigsiirkwn gllsamadad hfdihfpldl
301	dvkmkamifg acflidfmyf ersppqrsr

Protein sequence isoform b (SEQ ID NO (104)):

1	msgvvptape qpagemenqt kppdprpdap peynshflpg ppgtavpppt gypgglpmgy
61	yspqqpstfp lyqpvggihp vryqpgkypm pnqsvpitwm pgptpmancp pgleylvqle
121	vqcppgvtig fvaehwnlcr avysiqnekk envmrvrgpc stygcgsdsv fevksldgis
181	nigsiirkwn gllsamadad hfdihfpldl dvkmkamifg acflidfmyf ersppqrsr

Protein sequence isoform c (SEQ ID NO (105)):

1	menqtkppdp rpdappeyns hflpgppgta vppptgypgg lpmgyyspqq pstfplyqpv
61	ggihpvryqp gkypmpnqsv pitwmpgptp mancppgley lvqlevqcpp gvtigfvaeh
121	wnlcravysi qnekkenvmr vrgpcstygc gsdsvfevks ldgisnigsi irkwngllsa
181	madadhfdih fpldldvkmk amifgacfli dfmyferspp qrsr
Gene ID:	Z6
Gene symbol:	AMOT
Gene description:	angiomotin
Unigene:	Hs.528051
Genbank:	AF286598
Entrez Gene:	154796
Refseq:	NM_133265|NM_001113490

Protein sequence isoform 2 (SEQ ID NO (106)):

1	mpraqpssas yqpvpadpfa ivsraqqmve ilsdenrnlr qelegcyekv arlqkvetei
61	qrvseayenl vkssskreal ekamrnkleg eirrmhdfnr direrletan kqlaekeyeg
121	sedtrktisq lfaknkesqr ekekleaela tarstnedqr rhieirdqal snaqakvvkl
181	eeelkkkqvy vdkvekmqqa lvqlqaacek reqlehrlrt rlereleslr iqqrqgncqp
241	tnvseynaaa lmellrekee rilaleadmt kweqkyleen vmrhfaldaa atvaaqrdtt
301	vishspntsy dtaleariqk eeeeilmank rcldmegrik tlhaqiiekd amikvlqqrs
361	rkepskteql scmrpakslm sisnagsgll shsstltgsp imeekrddks wkgslgillg
421	gdyraeyvps tpspvppstp llsahsktgs rdcstqterg tesnktaava pisvpapvaa
481	aataaaitat aatitttmva aapvavaaaa apaaaaapsp ataaataaav spaaagqipa
541	aasvasaaav apsaaaaaav qvapaapapv papalvpvpa paaaqasapa qtqaptsapa
601	vaptpaptpt pavaqaevpa spatgpgphr lsipsltcnp dktdgpvfhs ntlerktpiq
661	ilgqepdaem veyli

Protein sequence isoform 1 (SEQ ID NO (107)):

1	mrnseeqpsg gttvlqrllq eqlrygnpse nrsllaihqq atgngppfps gsgnpgpqsd
61	vlspqdhhqq lvahaarqep qgqeiqsenl imekqlsprm qnneelptye eakvqsqyfr
121	gqqhasvgaa fyvtgvtnqk mrtegrpsvq rlnpgkmhqd eglrdlkqgh vrslserlmq
181	mslatsgvka hppvtsapls ppqpndlykn ptsssefyka qgplpnqhsl kgmehrgppp
241	eypfkgmppq svvckpqepg hfysehrlnq pgrtegqlmr yqhppeygaa rpaqdislpl
301	sarnsqphsp tssltsggsl pllqsppstr lsparhplvp nqgdhsahlp rpqqhflpnq
361	ahqgdhyrls qpglsqqqqq qqqqhhhhhh hqqqqqqqpq qqpgeaysam praqpssasy
421	qpvpadpfai vsraqqmvei lsdenrnlrq elegcyekva rlqkveteiq rvseayenlv
481	kssskreale kamrnklege irrmhdfnrd lrerletank qlaekeyegs edtrktisql
541	faknkesqre kekleaelat arstnedqrr hieirdqals naqakvvkle eelkkkqvyv
601	dkvekmqqal vqlqaacekr eqlehrlrtr lereleslri qqrqgncqpt nvseynaaal
661	mellrekeer ilaleadmtk weqkyleenv mrhfaldaaa tvaaqrdttv ishspntsyd
721	taleariqke eeeilmankr cldmegrikt lhaqiiekda mikvlqqrsr kepskteqls
781	cmrpakslms isnagsglls hsstltgspi meekrddksw kgslgillgg dyraeyvpst
841	pspvppstpl lsahsktgsr dcstqtergt esnktaavap isvpapvaaa ataaaitata
901	atitttmvaa apvavaaaaa paaaaapspa taaataaavs paaagqipaa asvasaaava
961	psaaaaaavq vapaapapvp apalvpvpap aaaqasapaq tqaptsapav aptpaptptp
1021	avaqaevpas patgpgphrl sipsltcnpd ktdgpvfhsn tlerktpiqi lgqepdaemv
1081	eyli
Gene ID:	Z7
Gene symbol:	ENPEP
Gene description:	glutamyl aminopeptidase (aminopeptidase A)
Unigene:	Hs.435765
Genbank:	L12468
Entrez Gene:	2028
Refseq:	NM_001977

Protein sequence (SEQ ID NO (108)):

1	mnfaeregsk ryciqtkhva ilcavvvgvg livglavglt rscdssgdgg pgtapapshl
61	psstaspsgp paqdqdicpa sedesgqwkn frlpdfvnpv hydlhvkpll eedtytgtvs
121	isinlsaptr ylwlhlretr itrlpelkrp sgdqvqvrrc feykkqeyvv veaeeeltps
181	sgdglylltm efagwlngsl vgfyrttyte ngqvksivat dheptdarks fpcfdepnkk
241	atytisithp keygalsnmp vakeesvddk wtrttfeksv pmstylvcfa vhqfdsvkri
301	snsgkpltiy vqpeqkhtae yaanitksvf dyfeeyfamn yslpkldkia ipdfgtgame
361	nwglityret nllydpkesa ssnqqrvatv vahelvhqwf gnivtmdwwe dlwlnegfas
421	ffeflgvnha etdwqmrdqm lledvlpvqe ddslmsshpi ivtvttpdei tsvfdgisys
481	kgssilrmle dwikpenfqk gcqmylekyq fknaktsdfw aaleeasrlp vkevmdtwtr
541	qmgypvlnvn gvknitqkrf lldpranpsq ppsdlgytwn ipvkwtedni tssvlfnrse
601	kegitlnssn psgnaflkin pdhigfyrvn yevatwdsia talslnhktf ssadraslid
661	dafalaraql ldykvalnlt kylkreenfl pwqrvisavt yiismfeddk elypmieeyf
721	qgqvkpiads lgwndagdhv tkllrssvlg fackmgdrea lnnasslfeq wlngtvslpv
781	nlrllvyryg mqnsgneisw nytleqyqkt slaqekekll yglasvknvt llsryldllk
841	dtnliktqdv ftviryisyn sygknmawnw iqlnwdylvn rytlnnrnlg rivtiaepfn
901	telqlwqmes ffakypqaga gekpreqvle tvknniewlk qhrntirewf fnllesg
Gene ID:	Z8
Gene symbol:	THY1
Gene description:	Thy-1 cell surface antigen
Unigene:	Hs.644697
Genbank:	AP003396
Entrez Gene:	7070
Refseq:	NM_006288

Protein sequence (SEQ ID NO (109)):

1	mnlaisiall ltvlqvsrgq kvtsltaclv dqslrldcrh entssspiqy efsltretkk
61	hvlfgtvgvp ehtyrsrtnf tskynmkvly lsaftskdeg tytcalhhsg hsppissqnv
121	tvlrdklvkc egisllaqnt swllllllsl sllqatdfms l