Annular disk for reduction of anastomotic tension and methods of using the same

An apparatus for forming an anastomosis between adjacent tissue sections is provided. The apparatus includes an anastomosis device including an anvil assembly having a shaft which is selectively attachable to a tubular body portion, wherein the tubular body portion includes at least one annular row of staples operatively disposed therein. The apparatus further includes a disk having an outer terminal portion and a substantially centrally located aperture. The disk includes an adhesive material at the outer terminal portion. Wherein the outer terminal portion of the disk extends radially outward beyond the outer-most row of the at least one annular row of staples to adhesively attach the tissue sections together radially outward of the at least one annular row of staples.

Transcutaneous analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Redundant temperature monitoring in electrosurgical systems for safety mitigation

A redundant temperature monitoring system and method for an electrosurgical system are provided. The temperature monitoring circuit includes at least one temperature sensor for sensing a temperature at a measuring point, a first temperature measurement circuit coupled to the at least one temperature sensor for generating a first temperature value, a second temperature measurement circuit coupled to the at least one temperature sensor for generating a second temperature value, and a control circuit for determining a difference between the first and second temperature values and for comparing the difference to a first predetermined threshold. If the difference is greater than the first predetermined threshold, the control circuit generates a warning signal. If the difference is greater than a second predetermined threshold, the control circuit generates an alarm signal and/or shuts down a power source of the electrosurgical system.

Systems and methods for delivering a medical implant

The present invention relates to apparatus and methods for endovascularly delivering and releasing a prosthesis, e.g., an aortic prosthesis, within and/or across a patient's native heart valve, referred to hereinafter as replacing the patient's heart valve. In some embodiments the delivery system comprises a plurality of first actuatable element adapted to engage a plurality of second elements in a first configuration to capture the implant within the delivery system, and wherein the plurality of first actuatable element are adapted to engage the plurality of second elements in a second configuration and to release the implant from the delivery system.

Methods and devices for delivery of prosthetic heart valves and other prosthetics

Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices are particularly adapted for use in minimally invasive surgical procedures. The preferred delivery device includes a catheter having a deployment mechanism attached to its distal end, and a handle mechanism attached to its proximal end. A plurality of tethers are provided to selectively restrain the valve during deployment. A number of mechanisms for active deployment of partially expanded prosthetic valves are also described.

Internet remote game server

A gaming system, including a game outcome server, an account handling device and a client device communicatively coupled via network, is described. The game outcome server may be operable to send command, instructions, data or combinations thereof that allow an interface for a wager-based game to be generated on the client device, generate a game outcome for the wager-based game that is displayed on the client device and generate an update to a player balance maintained on the account handling device. The account handling device is operable to provide gaming services related to the game play on the client device including a) web-site hosting where the web-site lists available gaming services including games provided by the game outcome server, b) accounting, c) money handling including player account management and d) player eligibility functions.

Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach

Methods and apparatus are provided for pulsed electric field neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other conditions in target neural fibers. In some embodiments, the ITEV PEF system comprises an intravascular catheter having one or more electrodes configured for intra-to-extravascular placement across a wall of patient's vessel into proximity with target neural fibers. With the electrode(s) passing from an intravascular position to an extravascular position prior to delivery of the PEF, a magnitude of applied voltage or energy delivered via the electrode(s) and necessary to achieve desired neuromodulation may be reduced relative to an intravascular PEF system having one or more electrodes positioned solely intravascularly. The methods and apparatus of the present invention may, for example, be used to modulate one or more target neural fibers that contribute to renal function.

Analyte sensors and methods of use

An analyte sensor system including a substrate, a first electrode disposed on a first surface of the substrate, a second electrode disposed on a second surface of the substrate, a third electrode provided in electrical contact with at least one of the first or second electrodes, where at least a portion of the first electrode and the second electrode are subcutaneously positioned in a patient, and where the third electrode is substantially entirely positioned external to the patient, and corresponding methods are provided.

Non-invasive fetal genetic screening by digital analysis

The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital PCR is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies do not present a mutational change in sequence, and are merely a change in the number of chromosomes, it has not been possible to detect them in a fetus without resorting to invasive techniques such as amniocentesis or chorionic villi sampling. Digital amplification allows the detection of aneuploidy using massively parallel amplification and detection methods, examining, e.g., 10,000 genome equivalents.

Reflection free launcher for electromagnetic guide wire

Guided wave radar (GWR) pulses are launched onto an electromagnetic guide wire using a compact launcher that includes an impedance matching element. The impedance matching element produces reflections that cancel launcher reflections. Short range echoes can be accurately detected after impedance matching. GWR operation in small tanks and in tanks containing low dielectric constant materials, such as propane, can be enhanced with the compact impedance-matched launcher.