Patent Applications published on Dec 1, 2011 - page 18

#5101
US20110294742A1
Chemistry; metallurgy

DEGRADABLE CLOSTRIDIAL TOXINS

#5102 ✅ Patent 8,779,092 granted on 2014-07-15
US20110294743A9
Human necessities

Metastasis-specific peptides and their diagnostic and therapeutic applications

#5103
US20110294744A1
Human necessities

CYCLOSPORIN EMULSIONS

#5104 ✅ Patent 9,700,509 granted on 2017-07-11
US20110294745A1
Human necessities

Solutions of lipophilic substances, especially medicinal solutions

#5105 ✅ Patent 9,468,602 granted on 2016-10-18
US20110294746A1
Human necessities

Pharmaceutical microemulsion for preventing supramolecular aggregation of amphiphilic molecules

#5106 ✅ Patent 8,298,550 granted on 2012-10-30
US20110294747A1
Human necessities

PEGylated mutated toxin

#5107 ✅ Patent 8,415,306 granted on 2013-04-09
US20110294748A1
Chemistry; metallurgy

Insulin-like growth factor 1 receptor binding peptides

#5108
US20110294749A1
Chemistry; metallurgy

DIAMINOPYRIMIDINECARBOXAMIDE DERIVATIVE

#5109 ✅ Patent 9,913,470 granted on 2018-03-13
US20110294750A1
Human necessities

Surface sterilisation by misting with a bioflavanoid solution

#5110 ✅ Patent 8,551,962 granted on 2013-10-08
US20110294751A1
Human necessities

High dosage doramectin formulation

#5111 ✅ Patent 8,324,177 granted on 2012-12-04
US20110294752A1
Human necessities

Triterpene compositions and methods for use thereof

#5112 ✅ Patent 9,243,245 granted on 2016-01-26
US20110294753A1
Chemistry; metallurgy

Means and methods for counteracting muscle disorders

#5113 ✅ Patent 8,530,444 granted on 2013-09-10
US20110294754A1
Chemistry; metallurgy

Pharmaceutical compounds

#5114 ✅ Patent 9,427,449 granted on 2016-08-30
US20110294755A1
Human necessities

Binding of galectin-3 by low molecular weight pectin

#5115 ✅ Patent 8,673,900 granted on 2014-03-18
US20110294756A1
Chemistry; metallurgy

Gamma secretase modulators

#5116 ✅ Patent 9,814,252 granted on 2017-11-14
US20110294757A1
Human necessities

Polar lipid mixtures, their preparation and uses

#5117 ✅ Patent 8,940,927 granted on 2015-01-27
US20110294758A1
Chemistry; metallurgy

Activators of glucokinase

#5118 ✅ Patent 8,394,405 granted on 2013-03-12
US20110294759A1
Human necessities

Once daily formulations of tetracyclines

#5119 ✅ Patent 9,839,628 granted on 2017-12-12
US20110294760A1
Human necessities

Compositions and methods for preventing sternal wound infections

#5120 ✅ Patent 8,691,573 granted on 2014-04-08
US20110294761A1
Chemistry; metallurgy

Stem cell cultures

#5121 ✅ Patent 8,258,121 granted on 2012-09-04
US20110294762A1
Human necessities

Glyceryl and glycol acid compounds

#5122
US20110294763A1
Human necessities

TRANSDERMAL DELIVERY OF DICOLFENAC, CARBAMAZEPINE AND BENZYDAMINE

#5123
US20110294764A1
Chemistry; metallurgy

2-METHYLENE-19,26-NOR-(20S)-1alpha-HYDROXYVITAMIN D3

#5124 ✅ Patent 8,575,224 granted on 2013-11-05
US20110294765A1
Human necessities

Procedure for obtaining an aqueous dispersion of alcohols and acids from jojoba oil, processes for obtaining self-emulsified jojoba oil, aqueous dispersions and emulsions of jojoba oil in the same and pharmaceutical or cosmetic compositions comprising the same

#5125
US20110294766A1
Chemistry; metallurgy

16 Alpha, 17 Alpha-Acetal Glucocorticosteroidal Derivatives and their Use

#5126
US20110294767A1
Human necessities

BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS

#5127
US20110294768A1
Human necessities

Ophthalmic Suspension for Ocular Use

#5128
US20110294769A1
Chemistry; metallurgy

NITROOXY DERIVATIVES OF GLUCOCORTICOIDS

#5129 ✅ Patent 8,697,131 granted on 2014-04-15
US20110294770A1
Human necessities

Method for producing pharmaceutical drug particles of small particle size

#5130 ✅ Patent 11,103,514 granted on 2021-08-31
US20110294771A1
Human necessities

Treatment of muscular dystrophy

#5131
US20110294772A1
Human necessities

USE OF CYCLOSQUARAMIDE COMPOUNDS AS ANTI-TUMOUR AGENTS

#5132 ✅ Patent 8,496,919 granted on 2013-07-30
US20110294773A1
Human necessities

Cosmetic composition and hair wash

#5133 ✅ Patent 8,298,543 granted on 2012-10-30
US20110294774A1
Human necessities

Identification and application of antibiotic synergy

#5134 ✅ Patent 8,450,306 granted on 2013-05-28
US20110294775A1
Chemistry; metallurgy

Bradykinin B1-receptor antagonists

#5135 ✅ Patent 8,431,695 granted on 2013-04-30
US20110294776A1
Chemistry; metallurgy

Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases

#5136 ✅ Patent 8,487,093 granted on 2013-07-16
US20110294777A1
Chemistry; metallurgy

β-lactamase inhibitors

#5137
US20110294778A1
Chemistry; metallurgy

HEPATITIS C INHIBITOR COMPOUNDS

#5138 ✅ Patent 8,263,584 granted on 2012-09-11
US20110294779A1
Chemistry; metallurgy

Imidazopyridines

#5139 ✅ Patent 8,796,256 granted on 2014-08-05
US20110294780A1
Chemistry; metallurgy

Substituted thiazolidinedione indazoles, indoles and benzotriazoles as estrogen-related receptor-α modulators

#5140 ✅ Patent 8,314,098 granted on 2012-11-20
US20110294781A1
Chemistry; metallurgy

Pyrazolo-pyrimidine compounds

#5141
US20110294782A1
Human necessities

SMALL MOLECULE PAK INHIBITORS

#5142
US20110294783A1
Human necessities

Insecticidal Compositions Having Improved Effect

#5143 ✅ Patent 8,759,337 granted on 2014-06-24
US20110294784A1
Chemistry; metallurgy

Gamma secretase modulators

#5144 ✅ Patent 9,464,075 granted on 2016-10-11
US20110294785A1
Chemistry; metallurgy

Influenza A virus inhibition

#5145
US20110294786A1
Chemistry; metallurgy

SUBSTITUTED BICYCLIC PYRIMIDONE DERIVATIVES

#5146 ✅ Patent 8,299,075 granted on 2012-10-30
US20110294787A1
Chemistry; metallurgy

Substituted thiomorpholine derivatives

#5147 ✅ Patent 8,541,455 granted on 2013-09-24
US20110294788A1
Chemistry; metallurgy

Derivatives of 2-pyridin-2-yl-pyrazol-3(2H)-one, preparation and therapeutic use thereof as HIF activators

#5148
US20110294789A1
Human necessities

COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY

#5149 ✅ Patent 8,309,578 granted on 2012-11-13
US20110294790A1
Chemistry; metallurgy

Bicyclic pyrazole and isoxazole derivatives as antitumor and antineurodegenerative agents

#5150
US20110294791A1
Chemistry; metallurgy

PIRENZEPINE AS AN AGENT IN CANCER TREATMENT

#5151
US20110294792A1
Chemistry; metallurgy

PURINE DERIVATIVES AS KINASE INHIBITORS

#5152 ✅ Patent 8,501,992 granted on 2013-08-06
US20110294793A1
Chemistry; metallurgy

Hydroxyphenyl sulfonamides as antiapoptotic bcl inhibitors

#5153
US20110294794A1
Human necessities

TREATMENT OF PROTEINOPATHIES USING A FARNESYL TRANSFERASE INHIBITOR

#5154 ✅ Patent 8,440,821 granted on 2013-05-14
US20110294795A1
Human necessities

Methods of synthesis and/or purification of diaminophenothiazinium compounds

#5155 ✅ Patent 8,481,536 granted on 2013-07-09
US20110294796A1
Chemistry; metallurgy

Benzotriazine inhibitors of kinases

#5156 ✅ Patent 8,318,738 granted on 2012-11-27
US20110294797A1
Chemistry; metallurgy

Reverse-turn mimetics and method relating thereto

#5157 ✅ Patent 8,263,764 granted on 2012-09-11
US20110294798A1
Chemistry; metallurgy

IL-12 Modulatory compounds

#5158
US20110294799A1
Chemistry; metallurgy

Organic Compounds

#5159 ✅ Patent 9,260,391 granted on 2016-02-16
US20110294800A1
Chemistry; metallurgy

Hypoglycemic dihydropyridones

#5160 ✅ Patent 8,815,872 granted on 2014-08-26
US20110294801A1
Chemistry; metallurgy

Macrocyclics pyrimidines as aurora kinase inhibitors

#5161 ✅ Patent 8,673,907 granted on 2014-03-18
US20110294802A1
Chemistry; metallurgy

Pharmaceutically acceptable salts of methyl (3-{ [[3-(6-amino- 2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl) propyl] (3-morpholin-4-ylpropyl) amino] methyl }phenyl) acetate and their use in therapy

#5162
US20110294803A1
Human necessities

PHOSPHATIDYLINOSITOL-3-KINASE P110 DELTA-TARGETED DRUGS IN THE TREATMENT OF CNS DISORDERS

#5163 ✅ Patent 8,471,038 granted on 2013-06-25
US20110294804A1
Chemistry; metallurgy

Bicyclic heterocyclic compound

#5164 ✅ Patent 8,435,987 granted on 2013-05-07
US20110294805A1
Chemistry; metallurgy

Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof

#5165 ✅ Patent 8,912,330 granted on 2014-12-16
US20110294806A1
Human necessities

Azaindole derivatives as kinase inhibitors

#5166 ✅ Patent 8,952,021 granted on 2015-02-10
US20110294807A1
Chemistry; metallurgy

Compounds for the prevention and treatment of cardiovascular disease

#5167 ✅ Patent 8,263,597 granted on 2012-09-11
US20110294808A1
Chemistry; metallurgy

Indazole compounds as CCR1 receptor antagonists

#5168 ✅ Patent 8,530,477 granted on 2013-09-10
US20110294809A1
Chemistry; metallurgy

Tropane urea derivatives, preparation thereof and therapeutic application thereof as modulators of the activity of 11betaHSD1

#5169
US20110294810A1
Chemistry; metallurgy

SUBSTITUTED (PYRIDYL)-AZINYLAMINE DERIVATIVES AS PLANT PROTECTION AGENTS

#5170 ✅ Patent 8,513,243 granted on 2013-08-20
US20110294811A1
Chemistry; metallurgy

ABT-263 crystalline forms

#5171 ✅ Patent 8,299,073 granted on 2012-10-30
US20110294812A1
Chemistry; metallurgy

P38 MAP kinase inhibitors

#5172
US20110294813A1
Chemistry; metallurgy

OXAZOLIDINONE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1

#5173 ✅ Patent 8,581,004 granted on 2013-11-12
US20110294814A1
Chemistry; metallurgy

Compounds for treating proliferative disorders

#5174
US20110294815A1
Chemistry; metallurgy

PROSTACYCLIN ANALOGS

#5175 ✅ Patent 8,445,676 granted on 2013-05-21
US20110294816A1
Chemistry; metallurgy

Pyrrolotriazine kinase inhibitors

#5176 ✅ Patent 8,476,275 granted on 2013-07-02
US20110294817A1
Chemistry; metallurgy

N-[piperazinyl hetaryl]arylsufonamide compounds with affinity for the dopamine D3 receptor

#5177 ✅ Patent 8,513,268 granted on 2013-08-20
US20110294818A1
Chemistry; metallurgy

1H-quinazoline-2,4-diones processes for their production, pharmaceutical compositions, and treatment for epilepsy

#5178 ✅ Patent 8,362,020 granted on 2013-01-29
US20110294819A1
Human necessities

Hepatitis C virus inhibitors

#5179
US20110294820A1
Chemistry; metallurgy

N-Oxides of n-Phenyl-2-pyrimidine-amine Derivatives

#5180 ✅ Patent 8,501,742 granted on 2013-08-06
US20110294821A1
Human necessities

Method of treating panic disorder

#5181 ✅ Patent 8,778,948 granted on 2014-07-15
US20110294822A1
Chemistry; metallurgy

Substituted phenylpiperazinyl aralkylalcohol derivatives, pharmaceutical compositions containing such derivatives and uses thereof

#5182
US20110294823A1
Human necessities

TREATMENT OF POST-TRAUMATIC STRESS DISORDER WITH TETRAHYDROINDOLONE ARYLPIPERZAINE COMPOUNDS

#5183
US20110294824A1
Human necessities

POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL)BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE

#5184 ✅ Patent 8,236,804 granted on 2012-08-07
US20110294825A1
Human necessities

Polymorphic forms of 1-′4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride

#5185 ✅ Patent 8,372,854 granted on 2013-02-12
US20110294826A1
Chemistry; metallurgy

Pyrrolo[2,3-D]pyrimidine compounds

#5186
US20110294827A1
Chemistry; metallurgy

IAP BINDING COMPOUNDS

#5187
US20110294828A1
Chemistry; metallurgy

PROCESS FOR PREPARING A POLYMORPH OF THE CHOLINE SALT OF A PYRIMIDIN-5-YL ACETIC ACID DERIVATIVE

#5188 ✅ Patent 8,580,799 granted on 2013-11-12
US20110294829A1
Chemistry; metallurgy

Fungicide hydroximoyl-heterocycles derivatives

#5189 ✅ Patent 8,222,420 granted on 2012-07-17
US20110294830A1
Chemistry; metallurgy

Nitrogen-containing compounds and harmful organism control agents

#5190 ✅ Patent 8,980,873 granted on 2015-03-17
US20110294831A1
Chemistry; metallurgy

11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene citrate salt

#5191 ✅ Patent 8,921,379 granted on 2014-12-30
US20110294832A1
Chemistry; metallurgy

Fused ring compound and use thereof

#5192
US20110294833A1
Human necessities

Methods for Healthy Aging

#5193 ✅ Patent 8,741,907 granted on 2014-06-03
US20110294834A1
Chemistry; metallurgy

Alkyl-substituted pyrazolopyrimidines

#5194
US20110294835A1
Human necessities

Muscarinic Agonists as Cognitive Enhancers

#5195
US20110294836A1
Chemistry; metallurgy

ARYL GPR119 AGONISTS AND USES THEREOF

#5196 ✅ Patent 9,126,935 granted on 2015-09-08
US20110294837A1
Chemistry; metallurgy

Aurora kinase modulators and methods of use

#5197 ✅ Patent 8,735,412 granted on 2014-05-27
US20110294838A1
Chemistry; metallurgy

Sulfoximine-substituted anilinopyrimidine derivatives as CDK inhibitors, the production thereof, and use as medicine

#5198 ✅ Patent 8,445,506 granted on 2013-05-21
US20110294839A1
Chemistry; metallurgy

Polymorphs of lopinavir

#5199 ✅ Patent 8,507,514 granted on 2013-08-13
US20110294840A1
Chemistry; metallurgy

Hydrazide compound and use of the same in pest control

#5200
US20110294841A1
Human necessities

NOVEL STATIN PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS OF TREATMENT

#5201
US20110294842A9
Chemistry; metallurgy

SPIRO (FURO [3, 2-C] PYRIDINE-3-3' -INDOL) -2' (1'H)-ONE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SODIUM-CHANNEL MEDIATED DISEASES, SUCH AS PAIN

#5202
US20110294843A1
Human necessities

ADMINISTRATION SCHEME OF POLAR OPIOID METABOLITES FOR POST-OPERATIVE PAIN MANAGEMENT

#5203 ✅ Patent 8,394,957 granted on 2013-03-12
US20110294844A1
Chemistry; metallurgy

9-aminonoscapine and its use in treating cancers, including drug-resistant cancers

#5204 ✅ Patent 8,299,116 granted on 2012-10-30
US20110294845A1
Human necessities

CCI-779 concentrate formulations

#5205 ✅ Patent 8,541,442 granted on 2013-09-24
US20110294846A1
Chemistry; metallurgy

Indole derivatives as anticancer agents

#5206
US20110294847A1
Human necessities

Novel Polymorphs Of Azabicyclohexane

#5207 ✅ Patent 10,301,265 granted on 2019-05-28
US20110294848A1
Chemistry; metallurgy

Small molecule inhibitors of botulinum neurotoxins

#5208 ✅ Patent 8,263,777 granted on 2012-09-11
US20110294849A1
Chemistry; metallurgy

Aminopyrazole triazolothiadiazole inhibitor of c-Met protein kinase

#5209 ✅ Patent 8,686,024 granted on 2014-04-01
US20110294850A1
Chemistry; metallurgy

Indoline derivatives

#5210 ✅ Patent 8,242,138 granted on 2012-08-14
US20110294851A1
Chemistry; metallurgy

Amidine-containing compounds useful as muscarinic receptor antagonists

#5211
US20110294852A1
Human necessities

Pharmaceutical Formulation Comprising Metformin and Repaglinide

#5212
US20110294853A1
Chemistry; metallurgy

Bis Aromatic Compounds for Use in the Treatment of Inflammation

#5213 ✅ Patent 8,796,470 granted on 2014-08-05
US20110294854A1
Chemistry; metallurgy

Substituted octahydrocyclopenta[c]pyrroles as calcium channel modulators

#5214
US20110294855A1
Human necessities

Active Compound Combinations

#5215
US20110294856A1
Chemistry; metallurgy

NOVEL OXADIAZOLE DERIVATIVES AND THEIR MEDICAL USE

#5216 ✅ Patent 9,018,238 granted on 2015-04-28
US20110294857A1
Chemistry; metallurgy

Inhibitor of casein kinase 1δ and casein kinase 1ε

#5217 ✅ Patent 8,969,389 granted on 2015-03-03
US20110294858A1
Human necessities

Substituted 6-methylnicotinamides as mGluR5 positive allosteric modulators

#5218
US20110294859A1
Chemistry; metallurgy

SUBSTITUTED PYRIDOXINE-LACTAM CARBOXYLATE SALTS

#5219
US20110294860A1
Human necessities

AQUEOUS ORAL PREPARATION OF STABLE AMLODIPINE

#5220
US20110294861A1
Human necessities

METHOD OF TREATMENT OF HEREDITARY HEMOCHROMATOSIS

#5221 ✅ Patent 8,470,862 granted on 2013-06-25
US20110294862A1
Human necessities

Treatment or prevention of hypotension and shock

#5222 ✅ Patent 8,349,884 granted on 2013-01-08
US20110294863A1
Chemistry; metallurgy

Fungicide N-cycloalkyl-N-bicyclimethylene-carboxamide derivatives

#5223
US20110294864A1
Human necessities

AQUEOUS COACERVATE COMPOSITIONS SUITABLE FOR MAKING POWDERS AND WATER-SOLUBLE FORMULATIONS OF BIOLOGICALLY-ACTIVE AGENTS

#5224
US20110294865A1
Physics

METHODS OF DETECTING A FRAGMENT OF NEUROSECRETORY PROTEIN VGF FOR DIAGNOSING ALZHEIMER'S DISEASE

#5225 ✅ Patent 8,088,751 granted on 2012-01-03
US20110294866A1
Chemistry; metallurgy

Pharmaceutical composition for treating dementia comprising ShRNA inhibiting S100a9 expression

#5226 ✅ Patent 8,293,886 granted on 2012-10-23
US20110294867A1
Chemistry; metallurgy

Sensizitation of cancer cells to therapy using sina targeting genes from the 1P and 19Q chromosomal regions

#5227
US20110294868A1
Chemistry; metallurgy

MODULATION OF TRANSTHYRETIN EXPRESSION

#5228 ✅ Patent 8,691,971 granted on 2014-04-08
US20110294869A1
Chemistry; metallurgy

Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference

#5229
US20110294870A1
Chemistry; metallurgy

TREATMENT OF TUMOR SUPPRESSOR GENE RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO THE GENE

#5230
US20110294871A1
Chemistry; metallurgy

LIPIDS, LIPID COMPLEXES AND USE THEREOF

#5231 ✅ Patent 8,552,166 granted on 2013-10-08
US20110294872A1
Human necessities

High-affinity nucleic acid aptamers against sclerostin protein

#5232
US20110294873A1
Chemistry; metallurgy

Gene Transfer Vectors Comprising At Least One Isolated DNA Molecule Having Insulator Or Boundary Properties And Methods To Identify The Same

#5233
US20110294874A1
Human necessities

DIAGNOSIS AND THERAPY OF ORGAN DYSFUNCTION USING SPHINGANINE-1-PHOSPHATE

#5234 ✅ Patent 8,258,177 granted on 2012-09-04
US20110294875A1
Chemistry; metallurgy

4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs

#5235
US20110294876A1
Chemistry; metallurgy

CYCLOHEXYL CARBAMATE COMPOUNDS AS ANTI-AGEING ACTIVES

#5236 ✅ Patent 9,174,935 granted on 2015-11-03
US20110294877A1
Chemistry; metallurgy

Transition metal complexes of bis[thiohydrazide amide] compounds

#5237 ✅ Patent 8,921,421 granted on 2014-12-30
US20110294878A1
Human necessities

Inhibitors of dimethylarginine dimethylaminohydrolase

#5238
US20110294879A1
Human necessities

METHOD OF TREATMENT OF FRAGILE X SYNDROME, DOWN'S SYNDROME, AUTISM AND RELATED DISORDERS

#5239 ✅ Patent 8,697,751 granted on 2014-04-15
US20110294880A1
Human necessities

Pharmaceutical composition containing prostaglandin

#5240
US20110294881A1
Human necessities

METHODS FOR TREATING LOWER URINARY TRACT DISORDERS USING alpha2delta SUBUNIT CALCIUM CHANNEL MODULATORS WITH SMOOTH MUSCLE MODULATORS

#5241 ✅ Patent 8,338,478 granted on 2012-12-25
US20110294882A1
Chemistry; metallurgy

Derivatives of 3,3-diphenylpropylamines

#5242 ✅ Patent 9,000,042 granted on 2015-04-07
US20110294883A1
Human necessities

α-Derivatives of -monounsaturated fatty acids intended for use as a drug

#5243 ✅ Patent 9,604,899 granted on 2017-03-28
US20110294884A1
Human necessities

Bipolar trans carotenoid salts and their uses

#5244
US20110294885A1
Human necessities

CONTROLLED-RELEASE PREGABALIN COMPOSITIONS

#5245
US20110294886A1
Human necessities

CONTROLLED-RELEASE TABLET FORMULATIONS OF PREGABALIN

#5246
US20110294887A1
Human necessities

CONTROLLED-RELEASE SOLUTION FORMULATIONS OF PREGABALIN

#5247
US20110294888A1
Human necessities

Use of Salts of Sulfur-Containing Compounds for Controlling Parasites

#5248 ✅ Patent 8,735,382 granted on 2014-05-27
US20110294889A1
Human necessities

Infusion and injection solution of levodopa

#5249
US20110294890A1
Human necessities

Neramexane for the treatment or prevention of inner ear disorders

#5250
US20110294891A1
Human necessities

METHODS AND COMPOSITIONS FOR TREATING OPTHALMIC CONDITIONS WITH RETINOL DERIVATIVES

#5251
US20110294892A1
Human necessities

Use of histone deacetylase inhibitors for the care of Philadephia-negative myeloproliferative syndromes

#5252
US20110294893A1
Human necessities

NON-ACIDIC CYCLOPENTANE HEPTANOIC ACID, 2-CYCLOALKYL OR ARYLALKYL DERIVATIVES AS THERAPEUTIC AGENTS

#5253
US20110294894A1
Human necessities

Pharmaceutical Composition for the Treatment of Solar Urticaria

#5254 ✅ Patent 8,623,921 granted on 2014-01-07
US20110294895A1
Human necessities

Bis(thio-hydrazide amide) formulation

#5255
US20110294896A1
Human necessities

Topical Treatment With Dapsone In G6PD-Deficient Patients

#5256
US20110294897A1
Human necessities

Treating Xerophthalmia With Compounds Increasing Meibomian Gland Secretion

#5257
US20110294898A1
Human necessities

Crystalline Forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol Hydrochloride

#5258 ✅ Patent 9,381,450 granted on 2016-07-05
US20110294899A1
Performing operations; transporting

Defoamer composition comprising alkoxylated 2-propylheptanol

#5259 ✅ Patent 8,835,509 granted on 2014-09-16
US20110294900A1
Human necessities

Self emulsifying drug delivery system for a curcuminoid based composition

#5260
US20110294901A1
Human necessities

FINELY PULVERIZED PHARMACEUTICAL COMPOSITION

#5261 ✅ Patent 8,202,912 granted on 2012-06-19
US20110294902A1
Human necessities

Pharmaceutical compositions providing enhanced drug concentrations

#5262 ✅ Patent 9,044,513 granted on 2015-06-02
US20110294903A1
Human necessities

Large particle size crystallised maltitol powder, method for preparing same and applications thereof, particularly in chocolate production

#5263
US20110294904A1
Human necessities

Dry Granulation Binders, Products, and Use Thereof

#5264 ✅ Patent 8,653,149 granted on 2014-02-18
US20110294905A1
Chemistry; metallurgy

Conversion of liquid heavy hydrocarbon feedstocks to gaseous products

#5265 ✅ Patent 8,268,897 granted on 2012-09-18
US20110294906A1
Chemistry; metallurgy

Incorporation of catalytic dehydrogenation into Fischer-Tropsch synthesis to lower carbon dioxide emissions

#5266 ✅ Patent 8,772,360 granted on 2014-07-08
US20110294907A1
Chemistry; metallurgy

Generating methanol using ultrapure, high pressure hydrogen

#5267
US20110294908A1
Performing operations; transporting

FISCHER-TROPSCH SYNTHESIS FE-BASED CATALYST, PROCESS OF PREPARATION AND APPLICATION THEREOF

#5268 ✅ Patent 9,254,584 granted on 2016-02-09
US20110294909A1
Performing operations; transporting

Process for adding a coupling agent to raw stock

#5269
US20110294910A1
Chemistry; metallurgy

EXPANDABLE PELLETIZED POLYAMIDE MATERIAL

#5270
US20110294911A1
Chemistry; metallurgy

POLYURETHANE SURFACTANT STABILIZED POLYURETHANE FOAMS

#5271 ✅ Patent 8,703,862 granted on 2014-04-22
US20110294912A1
Chemistry; metallurgy

Reinforced thermoplastic molding compositions based on polyarylene ethers

#5272
US20110294913A1
Chemistry; metallurgy

FLEXIBLE MATERIAL FOR SURFACE ADHESIVE RULE

#5273 ✅ Patent 8,222,353 granted on 2012-07-17
US20110294914A1
Chemistry; metallurgy

Wettable hydrogels comprising acyclic polyamides

#5274 ✅ Patent 8,623,937 granted on 2014-01-07
US20110294915A1
Chemistry; metallurgy

Rubber compound containing a blocked mercaptosilane coupling agent

#5275
US20110294916A1
Chemistry; metallurgy

HYDROPHILIC MARKING FILM HAVING PLASMA CHEMICAL VAPOR DEPOSITION TREATED PROTECTIVE LAYER

#5276 ✅ Patent 8,455,588 granted on 2013-06-04
US20110294917A1
Chemistry; metallurgy

Use of recycled plastics for structural building forms

#5277 ✅ Patent 10,550,269 granted on 2020-02-04
US20110294918A1
Chemistry; metallurgy

Anti-corrosive paintings and coatings containing nanoparticles

#5278 ✅ Patent 8,378,031 granted on 2013-02-19
US20110294919A1
Chemistry; metallurgy

Coating composition and cured film formed therefrom

#5279
US20110294920A1
Chemistry; metallurgy

DOPO-FLAME RETARDANT IN EPOXY RESINS

#5280 ✅ Patent 8,679,632 granted on 2014-03-25
US20110294921A1
Chemistry; metallurgy

Fusion bonded epoxy coating compositions that include magnesium oxide

#5281
US20110294922A1
Chemistry; metallurgy

ENCAPSULATION OF PHOSPHORUS PENTASULFIDE

#5282 ✅ Patent 8,653,162 granted on 2014-02-18
US20110294923A1
Chemistry; metallurgy

Polymerization mixture that can be produced without water

#5283 ✅ Patent 9,079,990 granted on 2015-07-14
US20110294924A1
Chemistry; metallurgy

Methods of production of alkylstyrene/isoolefin polymers

#5284
US20110294925A1
Chemistry; metallurgy

COMPOSITE FROM HEMICELLULOSE EXTRACTED WOOD WITH IMPROVED PERFORMANCE AND REDUCED EMISSIONS

#5285 ✅ Patent 9,499,657 granted on 2016-11-22
US20110294926A1
Chemistry; metallurgy

Binder for granular and/or fibrous substrates

#5286 ✅ Patent 9,200,161 granted on 2015-12-01
US20110294927A1
Chemistry; metallurgy

Bio-oil formulation as an asphalt substitute

#5287
US20110294928A1
Chemistry; metallurgy

POLYCARBONATE RESIN COMPOSITION

#5288 ✅ Patent 8,436,125 granted on 2013-05-07
US20110294929A1
Chemistry; metallurgy

Materials, methods for production thereof and components thereof

#5289 ✅ Patent 8,710,124 granted on 2014-04-29
US20110294930A1
Chemistry; metallurgy

Flame retardant thermoplastic elastomers

#5290 ✅ Patent 8,912,260 granted on 2014-12-16
US20110294931A1
Chemistry; metallurgy

Liquid film based on silane-terminated polymers

#5291
US20110294932A1
Chemistry; metallurgy

COMPOSITION AND METHOD FOR PROVIDING STAIN RELEASE OR STAIN REPELLENCY TO SUBSTRATES

#5292
US20110294933A1
Chemistry; metallurgy

POLYHYDROXYFUNCTIONAL POLYSILOXANES FOR INCREASING THE SURFACE ENERGY OF THERMOPLASTICS, METHOD FOR PRODUCTION AND USE THEREOF

#5293
US20110294934A1
Chemistry; metallurgy

TWO-COMPONENT COATING COMPOSITIONS FOR FLEXIBLE COATINGS

#5294 ✅ Patent 9,637,418 granted on 2017-05-02
US20110294935A1
Chemistry; metallurgy

Method for preparing an ester and binder system

#5295
US20110294936A1
Chemistry; metallurgy

TIRE TREAD RUBBER COMPOSITION AND PNEUMATIC TIRE USING THE SAME

#5296 ✅ Patent 8,975,333 granted on 2015-03-10
US20110294937A1
Chemistry; metallurgy

Method for improving flowability of random polypropylene powder

#5297 ✅ Patent 9,234,063 granted on 2016-01-12
US20110294938A1
Chemistry; metallurgy

Perfluoroelastomer

#5298 ✅ Patent 8,242,236 granted on 2012-08-14
US20110294939A1
Chemistry; metallurgy

Elastomeric nanocomposite manufacturing

#5299 ✅ Patent 8,841,390 granted on 2014-09-23
US20110294940A1
Chemistry; metallurgy

Method for improving flowability of heterophasic polypropylene powder

#5300
US20110294941A1
Performing operations; transporting

VINYL CHLORIDE-BASED RESIN COMPOSITION, METHOD OF PRODUCING VINYL CHLORIDE-BASED POLYMER COMPOSITION, AND VINYL CHLORIDE-BASED POLYMER COMPOSITION OBTAINED THEREBY

#5301 ✅ Patent 8,263,700 granted on 2012-09-11
US20110294942A1
Chemistry; metallurgy

Pigment dispersions, related coating compositions and coated substrates

#5302 ✅ Patent 8,829,108 granted on 2014-09-09
US20110294943A1
Chemistry; metallurgy

Fibers sized with polyetherketoneketones

#5303
US20110294944A1
Chemistry; metallurgy

Perfluoroelastomer

#5304 ✅ Patent 8,362,168 granted on 2013-01-29
US20110294945A1
Chemistry; metallurgy

Aqueous fluorine-containing polymer dispersion

#5305 ✅ Patent 9,133,292 granted on 2015-09-15
US20110294946A1
Chemistry; metallurgy

Hydroxyl functional oil polyol acrylic graft copolymers

#5306
US20110294947A1
Chemistry; metallurgy

PAINT COMPOSITION

#5307
US20110294948A1
Chemistry; metallurgy

AROMATIC GROUP-CONTAINING (METH) ACRYLATE COMPOUND

#5308 ✅ Patent 8,633,275 granted on 2014-01-21
US20110294949A1
Chemistry; metallurgy

Rubber composition for breaker and pneumatic tire

#5309 ✅ Patent 8,859,693 granted on 2014-10-14
US20110294950A1
Chemistry; metallurgy

Curable silicone composition that provides a highly transparent cured silicone material

#5310 ✅ Patent 8,623,957 granted on 2014-01-07
US20110294951A1
Chemistry; metallurgy

Method of preparing fluoropolymers by aqueous emulsion polymerization

#5311
US20110294952A1
Human necessities

Optimized Drug Conjugates

#5312 ✅ Patent 8,957,155 granted on 2015-02-17
US20110294953A1
Chemistry; metallurgy

Blocked mercaptosilane coupling agent

#5313 ✅ Patent 9,688,801 granted on 2017-06-27
US20110294954A1
Chemistry; metallurgy

Vinyl polymer powder, curable resin composition and cured substance

#5314
US20110294955A1
Chemistry; metallurgy

THERMOPLASTIC POLYESTER ELASTOMER COMPOSITION INCLUDING IONOMER

#5315 ✅ Patent 8,273,824 granted on 2012-09-25
US20110294956A1
Chemistry; metallurgy

Process for producing resin composition

#5316 ✅ Patent 8,481,658 granted on 2013-07-09
US20110294957A1
Chemistry; metallurgy

Method for transitioning between incompatible olefin polymerization catalyst systems

#5317 ✅ Patent 9,080,000 granted on 2015-07-14
US20110294958A1
Chemistry; metallurgy

Method of forming a non-random copolymer

#5318 ✅ Patent 8,742,063 granted on 2014-06-03
US20110294959A1
Chemistry; metallurgy

Polymer bonded redox molecules and methods of making the same

#5319
US20110294960A1
Chemistry; metallurgy

POLYLACTIDE COPOLYMERS

#5320
US20110294961A1
Chemistry; metallurgy

THERMOPLASTIC POLYESTER ELASTOMER COMPOSITIONS

#5321 ✅ Patent 8,834,763 granted on 2014-09-16
US20110294962A1
Textiles; paper

Cross linked fibers and methods of making same using transition metal ions

#5322
US20110294963A1
Chemistry; metallurgy

METHOD OF TOUGHENING EPOXY RESIN AND TOUGHENED EPOXY RESIN COMPOSITE

#5323 ✅ Patent 8,481,775 granted on 2013-07-09
US20110294964A1
Chemistry; metallurgy

Method for improving the color index of organopolysiloxanes

#5324 ✅ Patent 8,604,151 granted on 2013-12-10
US20110294965A1
Chemistry; metallurgy

Bodied siloxane resin including M, Q, and T-propyl units and capped with additional M units

#5325 ✅ Patent 8,444,762 granted on 2013-05-21
US20110294966A1
Chemistry; metallurgy

Varnish compositions for electrical insulation and method of using the same

#5326 ✅ Patent 8,273,835 granted on 2012-09-25
US20110294967A1
Performing operations; transporting

Method for ethylene polymerization in a tubular reactor with reduced output

#5327 ✅ Patent 8,883,939 granted on 2014-11-11
US20110294968A1
Performing operations; transporting

Method for producing polymers and reactor for carrying out said method

#5328 ✅ Patent 8,664,140 granted on 2014-03-04
US20110294969A1
Chemistry; metallurgy

Catalyst system for olefin polymerization, its production and use

#5329 ✅ Patent 9,562,119 granted on 2017-02-07
US20110294970A1
Chemistry; metallurgy

Ethylene polymerization catalysts

#5330 ✅ Patent 8,324,334 granted on 2012-12-04
US20110294971A1
Chemistry; metallurgy

Telechelic olefin metathesis polymers from renewable feedstocks

#5331
US20110294972A1
Chemistry; metallurgy

Olefin Polymerization Catalysts

#5332 ✅ Patent 8,148,481 granted on 2012-04-03
US20110294973A1
Chemistry; metallurgy

Method for seed bed treatment for a polymerization reaction

#5333 ✅ Patent 8,697,912 granted on 2014-04-15
US20110294974A1
Chemistry; metallurgy

N-(1-hydroxyethyl) carboxamide compound and process for producing same

#5334 ✅ Patent 8,907,035 granted on 2014-12-09
US20110294975A1
Chemistry; metallurgy

Polyethylene Copolymers

#5335 ✅ Patent 8,758,935 granted on 2014-06-24
US20110294976A1
Electricity

Soluble polymer with multi-stable electric states and products comprising such polymer

#5336 ✅ Patent 8,697,834 granted on 2014-04-15
US20110294977A1
Chemistry; metallurgy

Polyalkylenepolyamines by homogeneously catalyzed alcohol amination

#5337 ✅ Patent 8,519,093 granted on 2013-08-27
US20110294978A1
Performing operations; transporting

Process and a device for the continuous treatment of mixed substances

#5338 ✅ Patent 9,005,954 granted on 2015-04-14
US20110294979A1
Chemistry; metallurgy

Methods for isolating bacteria

#5339 ✅ Patent 9,149,540 granted on 2015-10-06
US20110294980A1
Human necessities

Polymer conjugate of folic acid or folic acid derivative

#5340 ✅ Patent 8,404,455 granted on 2013-03-26
US20110294981A1
Physics

Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides

#5341
US20110294982A1
Chemistry; metallurgy

AMINO ACID SEQUENCES DIRECTED AGAINST INTEGRINS AND USES THEREOF

#5342
US20110294983A1
Chemistry; metallurgy

SINGLE-CHAIN ANTIPARALLEL COILED COIL PROTEINS

#5343 ✅ Patent 9,139,654 granted on 2015-09-22
US20110294984A1
Chemistry; metallurgy

Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity

#5344
US20110294985A1
Chemistry; metallurgy

Remedy for Chronic Inflammation and Antibody to be Used Therein

#5345
US20110294986A1
Chemistry; metallurgy

Methods For Detecting Th1 Cells

#5346 ✅ Patent 8,491,908 granted on 2013-07-23
US20110294987A1
Chemistry; metallurgy

Composite particle, contrast agent for photoacoustic imaging, and method for producing the composite particle

#5347
US20110294988A1
Chemistry; metallurgy

Purification Process

#5348 ✅ Patent 8,436,142 granted on 2013-05-07
US20110294989A1
Chemistry; metallurgy

Processing of recombinant human G-CSF precursor

#5349
US20110294990A1
Chemistry; metallurgy

Refolding of Recombinant Proteins

#5350 ✅ Patent 9,260,464 granted on 2016-02-16
US20110294991A1
Chemistry; metallurgy

Process for recovering lignin

#5351
US20110294992A1
Chemistry; metallurgy

METAL RESPONSIVE MRI-AGENTS

#5352 ✅ Patent 8,298,299 granted on 2012-10-30
US20110294993A1
Chemistry; metallurgy

Azo pigment or tautomer thereof, process for producing same, pigment dispersion, coloring composition, inkjet recording ink, coloring composition for color filter, and color filter

#5353
US20110294994A1
Chemistry; metallurgy

Gentamicin Separation Method

#5354
US20110294995A1
Performing operations; transporting

Functionalized nanoparticles and other particles and methods for making and using same

#5355
US20110294996A1
Chemistry; metallurgy

QUANTUM UNIT OF INHERITANCE

#5356
US20110294997A1
Physics

METAL ENHANCED FLUORESCENCE-BASED SENSING METHODS

#5357 ✅ Patent 8,497,365 granted on 2013-07-30
US20110294998A1
Human necessities

Cyclodextrin-based polymers for therapeutics delivery

#5358 ✅ Patent 8,415,468 granted on 2013-04-09
US20110294999A1
Chemistry; metallurgy

Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

#5359 ✅ Patent 8,119,797 granted on 2012-02-21
US20110295000A1
Chemistry; metallurgy

Production method

#5360
US20110295001A1
Chemistry; metallurgy

Method for Producing Triazine Carbamates Using Chloroformates

#5361 ✅ Patent 9,056,869 granted on 2015-06-16
US20110295002A1
Chemistry; metallurgy

Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof

#5362 ✅ Patent 8,143,395 granted on 2012-03-27
US20110295003A1
Chemistry; metallurgy

Process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines

#5363 ✅ Patent 8,349,856 granted on 2013-01-08
US20110295004A1
Chemistry; metallurgy

Quinazoline based EGFR inhibitors

#5364
US20110295005A1
Chemistry; metallurgy

PROCESS FOR PREPARING PYRIMIDINE DERIVATIVES

#5365
US20110295006A1
Chemistry; metallurgy

CYCLIC DIPEPTIDES AS FEED ADDITIVES

#5366
US20110295007A1
Chemistry; metallurgy

SOLID FORMS OF [4-(3-FLUORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL-[5-METHANESULFONYL-2-((S)-2,2,2-TRIFLUORO-1-METHYL-ETHOXY)-PHENYL]-METHANONE

#5367 ✅ Patent 8,754,248 granted on 2014-06-17
US20110295008A1
Chemistry; metallurgy

Process for preparing cationic ruthenium complexes

#5368 ✅ Patent 8,765,799 granted on 2014-07-01
US20110295009A1
Chemistry; metallurgy

Streptospirole derivatives

#5369 ✅ Patent 8,404,892 granted on 2013-03-26
US20110295010A1
Chemistry; metallurgy

Aromatic amic acid salts and compositions

#5370 ✅ Patent 8,722,891 granted on 2014-05-13
US20110295011A1
Chemistry; metallurgy

Conjugate addition reactions using bifunctional -alkaloid-based catalysts

#5371 ✅ Patent 8,153,800 granted on 2012-04-10
US20110295012A1
Chemistry; metallurgy

Macrocyclic inhibitors of hepatitis C virus

#5372
US20110295013A1
Chemistry; metallurgy

PROCESS FOR PREPARING 1-(4-PIPERIDINYL)BENZIMIDAZOLONE DERIVATIVES

#5373
US20110295014A1
Chemistry; metallurgy

PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES

#5374 ✅ Patent 8,558,000 granted on 2013-10-15
US20110295015A1
Chemistry; metallurgy

4-pyridinone compounds and their use for cancer

#5375
US20110295016A1
Chemistry; metallurgy

A NEW PROCESS FOR PREPARING 4-[4-METHYL-5-(CL-10ALKYLTHIO/C5-10ARYL-CL-6ALKYLTHIO)-4H-1,2,4-TRIAZOL-3-YL]PYRIDINES

#5376 ✅ Patent 9,028,976 granted on 2015-05-12
US20110295017A1
Chemistry; metallurgy

Organic EL device

#5377 ✅ Patent 8,378,113 granted on 2013-02-19
US20110295018A1
Chemistry; metallurgy

Process for the manufacture of an intermediate in the synthesis of dabigatran

#5378 ✅ Patent 8,604,071 granted on 2013-12-10
US20110295019A1
Chemistry; metallurgy

Method for producing hydroxymethyl diphenyloxiranes and corresponding 1-azolylmethyl-1,2-diphenyloxiranes

#5379
US20110295020A1
Human necessities

Process For The Synthesis Of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane

#5380
US20110295021A1
Chemistry; metallurgy

METHOD OF CRYSTALLIZING CARNOSOL

#5381 ✅ Patent 8,575,366 granted on 2013-11-05
US20110295022A1
Chemistry; metallurgy

Method for producing 2-halogenomethylphenyl acetic acid derivatives

#5382 ✅ Patent 8,512,995 granted on 2013-08-20
US20110295023A1
Chemistry; metallurgy

DNA encoding polypeptide involved in biosynthesis of herboxidiene

#5383 ✅ Patent 8,779,169 granted on 2014-07-15
US20110295024A1
Chemistry; metallurgy

Process for the preparation of 2 substituted tetrahydropyranols

#5384
US20110295025A1
Chemistry; metallurgy

PROCESS FOR THE PREPARATION OF CHOLYL-L-LYSINE

#5385 ✅ Patent 8,614,343 granted on 2013-12-24
US20110295026A1
Chemistry; metallurgy

Process for the production of a fatty acid/carnitine derivative

#5386
US20110295027A1
Chemistry; metallurgy

Catalytic Isomerisation of Fatty Acid Esters

#5387 ✅ Patent 10,392,578 granted on 2019-08-27
US20110295028A1
Chemistry; metallurgy

Extraction of lipid from cells and products therefrom

#5388 ✅ Patent 8,691,365 granted on 2014-04-08
US20110295029A1
Electricity

Nanoparticle dispersions with low aggregation levels

#5389 ✅ Patent 8,426,623 granted on 2013-04-23
US20110295030A1
Chemistry; metallurgy

Surface modified nanoparticle and preparation method thereof

#5390 ✅ Patent 8,329,931 granted on 2012-12-11
US20110295031A1
Chemistry; metallurgy

Organoaluminum compound

#5391 ✅ Patent 8,367,854 granted on 2013-02-05
US20110295032A1
Chemistry; metallurgy

Method for producing and stabilizing oligoaminosilanes

#5392 ✅ Patent 8,329,933 granted on 2012-12-11
US20110295033A1
Chemistry; metallurgy

Low-impurity organosilicon product as precursor for CVD

#5393 ✅ Patent 8,324,271 granted on 2012-12-04
US20110295034A1
Human necessities

Eye drop composition containing isopropyl unoprostone

#5394 ✅ Patent 8,624,062 granted on 2014-01-07
US20110295035A1
Chemistry; metallurgy

Method for producing phenylacetamide compound

#5395 ✅ Patent 8,604,241 granted on 2013-12-10
US20110295036A1
Chemistry; metallurgy

Method for synthesis of (1S, 2R)-milnacipran

#5396
US20110295037A1
Chemistry; metallurgy

PROCESSES FOR PREPARING CINACALCET HYDROCHLORIDE AND POLYMORPHIC FORMS THEREOF

#5397
US20110295038A1
Chemistry; metallurgy

Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds

#5398 ✅ Patent 8,609,899 granted on 2013-12-17
US20110295039A1
Chemistry; metallurgy

Process for preparing toluenediamine by hydrogenation of dinitrotoluene

#5399 ✅ Patent 8,318,984 granted on 2012-11-27
US20110295040A1
Chemistry; metallurgy

Inducing cyathin Aproduction

#5400 ✅ Patent 8,481,790 granted on 2013-07-09
US20110295041A1
Performing operations; transporting

Catalyst for producing unsaturated aldehyde by oxidation of lower olefin at high space velocity