Patent Applications published on Jan 19, 2012 - page 15

#4201 ✅ Patent 8,192,934 granted on 2012-06-05
US20120015831A1
Chemistry; metallurgy

Method for delivering nucleic acid into eukaryotic genomes

#4202
US20120015832A1
Chemistry; metallurgy

METHODS, PANELS OF IDENTIFICATION MARKERS, AND KITS FOR IDENTIFYING FORENSIC SAMPLES

#4203 ✅ Patent 10,222,333 granted on 2019-03-05
US20120015833A1
Physics

Method and apparatus for detecting molecules

#4204 ✅ Patent 10,095,842 granted on 2018-10-09
US20120015834A1
Physics

Methods for artificial combinatorial control of biological systems

#4205
US20120015835A1
Physics

Devices and Methods for Enrichment and Alteration of Circulating Tumor Cells and Other Particles

#4206 ✅ Patent 8,563,247 granted on 2013-10-22
US20120015836A1
Chemistry; metallurgy

Kits for multiplexed nucleic acid analysis by capture of single-stranded DNA produced from double-stranded target fragments

#4207
US20120015837A1
Physics

METHOD FOR DIAGNOSING ENDOMETRIAL CANCER

#4208 ✅ Patent 8,962,307 granted on 2015-02-24
US20120015838A1
Chemistry; metallurgy

Method and kit for diagnosing autism using gene expression profiling

#4209
US20120015839A1
Chemistry; metallurgy

RECURRENT GENE FUSIONS IN CANCER

#4210
US20120015840A1
Chemistry; metallurgy

METHODS FOR GENERATION OF RNA AND (POLY)PEPTIDE LIBRARIES AND THEIR USE

#4211
US20120015841A1
Physics

NOVEL CELL LINES AND METHODS

#4212
US20120015842A1
Chemistry; metallurgy

Enumeration Of Nucleic Acids

#4213
US20120015843A1
Physics

GENE AND GENE EXPRESSED PROTEIN TARGETS DEPICTING BIOMARKER PATTERNS AND SIGNATURE SETS BY TUMOR TYPE

#4214 ✅ Patent 9,725,758 granted on 2017-08-08
US20120015844A1
Chemistry; metallurgy

Device and method for producing a replicate or derivative from an array of molecules, and applications thereof

#4215
US20120015845A1
Physics

MARKERS FOR THE DIAGNOSIS OF AML, B-ALL AND T-ALL

#4216
US20120015846A1
Physics

Label-free Cellular Pharmacology For Drug Antitarget Assessment

#4217 ✅ Patent 9,128,095 granted on 2015-09-08
US20120015847A1
Physics

Diagnosis or prognosis of lung cancer and colorectal cancer based on expression level of glutaredoxin 3

#4218
US20120015848A1
Physics

DISPOSABLE REACTION VESSEL WITH INTEGRATED OPTICAL ELEMENTS

#4219 ✅ Patent 9,534,217 granted on 2017-01-03
US20120015849A1
Chemistry; metallurgy

Method of creating a library of bacterial clones with varying levels of gene expression

#4220
US20120015850A1
Chemistry; metallurgy

siRNA targeting Superoxide

#4221
US20120015851A1
Performing operations; transporting

METHOD AND DEVICE FOR RAPID, DETECTION OF SPECIFIC REACTIONS USING NON-MAGNETIC AND MAGNETIC NANOPARTICLES

#4222 ✅ Patent 8,822,386 granted on 2014-09-02
US20120015852A1
Chemistry; metallurgy

Nanofluids and methods of use for drilling and completion fluids

#4223 ✅ Patent 8,580,716 granted on 2013-11-12
US20120015853A1
Chemistry; metallurgy

Overbased magnesium oxide dispersions

#4224
US20120015854A1
Chemistry; metallurgy

Olefinic Copolymer Compositions for Viscosity Modification of Motor Oil

#4225 ✅ Patent 8,778,858 granted on 2014-07-15
US20120015855A1
Chemistry; metallurgy

Amine derivatives as friction modifiers in lubricants

#4226 ✅ Patent 8,119,584 granted on 2012-02-21
US20120015856A1
Chemistry; metallurgy

Universal aqueous cleaning solution for electric shavers

#4227 ✅ Patent 9,074,169 granted on 2015-07-07
US20120015857A1
Chemistry; metallurgy

Lithographic tool in situ clean formulations

#4228
US20120015858A1
Chemistry; metallurgy

CLEANING AGENT

#4229
US20120015859A1
Chemistry; metallurgy

FLUID BLEACHING AGENT COMPOSITION

#4230
US20120015860A1
Chemistry; metallurgy

GENTLE BLEACHING AGENT

#4231 ✅ Patent 8,802,616 granted on 2014-08-12
US20120015861A1
Chemistry; metallurgy

Polymers for laundry detergents

#4232 ✅ Patent 8,609,602 granted on 2013-12-17
US20120015862A1
Chemistry; metallurgy

Cleaning solution

#4233 ✅ Patent 8,637,443 granted on 2014-01-28
US20120015863A1
Chemistry; metallurgy

Cleaning compositions and methods comprising a hydrofluoro-olefin or hydrochlorofluoro-olefin solvent

#4234
US20120015864A1
Chemistry; metallurgy

Low Solids, High Viscosity Fabric Softener Compositions and Process for Making the Same

#4235 ✅ Patent 9,107,931 granted on 2015-08-18
US20120015865A1
Human necessities

Class of cationic lipids for transporting active agents into cells

#4236 ✅ Patent 9,107,911 granted on 2015-08-18
US20120015866A1
Chemistry; metallurgy

Prodrugs of heteraromatic compounds

#4237 ✅ Patent 9,273,111 granted on 2016-03-01
US20120015867A1
Human necessities

Therapeutic TREM-1 peptides

#4238 ✅ Patent 8,361,968 granted on 2013-01-29
US20120015868A1
Chemistry; metallurgy

Metastin derivatives and use thereof

#4239 ✅ Patent 8,377,870 granted on 2013-02-19
US20120015869A1
Human necessities

Antimicrobial aqueous solution and its preparation method

#4240 ✅ Patent 8,552,147 granted on 2013-10-08
US20120015870A1
Chemistry; metallurgy

Peptides and compositions for prevention of cell adhesion and methods of using same

#4241
US20120015871A1
Chemistry; metallurgy

COMPLEMENT RECEPTOR 2 TARGETED COMPLEMENT MODULATORS

#4242 ✅ Patent 8,540,997 granted on 2013-09-24
US20120015872A1
Chemistry; metallurgy

Complement receptor 1 and 2 fusion proteins

#4243 ✅ Patent 8,513,381 granted on 2013-08-20
US20120015873A1
Chemistry; metallurgy

Melanocortin analogs with antimicrobial activity

#4244
US20120015874A1
Chemistry; metallurgy

NOVEL INHIBITORS OF RETROVIRAL REVERSE TRANSCRIPTACE

#4245
US20120015875A1
Human necessities

Use Of Oxandrolone In The Treatment Of Burns And Other Wounds

#4246 ✅ Patent 8,921,314 granted on 2014-12-30
US20120015876A1
Chemistry; metallurgy

Conjugates of GLP-1 agonists and uses thereof

#4247 ✅ Patent 8,361,957 granted on 2013-01-29
US20120015877A1
Chemistry; metallurgy

Isolated GDF trap polypeptide

#4248 ✅ Patent 8,618,043 granted on 2013-12-31
US20120015878A1
Human necessities

Use of ADNF polypeptides for treating anxiety and depression

#4249
US20120015879A1
Human necessities

Unitary combinations of FSH and hCG

#4250
US20120015880A1
Human necessities

INTRANASAL DESMOPRESSIN ADMINISTRATION

#4251 ✅ Patent 9,114,144 granted on 2015-08-25
US20120015881A1
Human necessities

Kallikrein-inhibitor therapies

#4252
US20120015882A1
Human necessities

COMPOSITION FOR REGULATING AUTONOMIC NERVOUS ACTIVITY AND METHOD FOR REGULATING AUTONOMIC NERVE

#4253 ✅ Patent 9,364,449 granted on 2016-06-14
US20120015883A1
Human necessities

Peptoid and synthetic oligomers, pharmaceutical compositions and methods of using same

#4254
US20120015884A1
Human necessities

Polypeptides for Specific Targeting to Otx2 Target Cells

#4255 ✅ Patent 8,685,926 granted on 2014-04-01
US20120015885A1
Chemistry; metallurgy

Compositions and method for CaMKII inhibitors and uses thereof

#4256
US20120015886A1
Chemistry; metallurgy

METHOD FOR PREPARING RECOMBINANT PEPTIDE FROM SPIDER VENOM AND METHOD FOR RELIEVING PAIN

#4257
US20120015887A1
Chemistry; metallurgy

SYNTHETIC PEPTIDE AND USES THEREOF

#4258 ✅ Patent 8,785,601 granted on 2014-07-22
US20120015888A1
Chemistry; metallurgy

T cell receptors and related materials and methods of use

#4259
US20120015889A1
Human necessities

METHOD FOR THE ADMINISTRATION OF LIGANDS, AGONISTS OF LIGANDS OF THE TNF FAMILY WITH REDUCED TOXICITY

#4260 ✅ Patent 8,759,505 granted on 2014-06-24
US20120015890A1
Chemistry; metallurgy

Use of soluble forms of CD83 and nucleic acids encoding them for the treatment or prevention of diseases

#4261 ✅ Patent 8,796,226 granted on 2014-08-05
US20120015891A1
Human necessities

Depot systems comprising glatiramer or a pharmacologically acceptable salt thereof

#4262 ✅ Patent 8,324,426 granted on 2012-12-04
US20120015892A1
Human necessities

Formulations of canfosfamide and their preparation

#4263 ✅ Patent 8,642,525 granted on 2014-02-04
US20120015893A1
Human necessities

Formulations containing sorbitan carboxylic acid ester

#4264 ✅ Patent 8,632,758 granted on 2014-01-21
US20120015894A1
Human necessities

Aqueous hair cleansing agent

#4265 ✅ Patent 8,383,685 granted on 2013-02-26
US20120015895A1
Human necessities

Use of RR/SR-ractopamine

#4266 ✅ Patent 8,507,453 granted on 2013-08-13
US20120015896A1
Human necessities

Anti-penicillin resistant pneumococci agent and novel 16-membered macrolide derivative

#4267 ✅ Patent 8,883,748 granted on 2014-11-11
US20120015897A1
Human necessities

Formulation for treating fungal infection

#4268 ✅ Patent 8,361,975 granted on 2013-01-29
US20120015898A1
Human necessities

Compounds and methods for treatment of sickle cell or complications associated therewith

#4269
US20120015899A1
Chemistry; metallurgy

MODIFIED PLANT VIRUS PARTICLES AND USES THEREFOR

#4270
US20120015900A1
Human necessities

Cobalamin Taxane Bioconjugates

#4271
US20120015901A1
Human necessities

METHODS AND PREPARATIONS FOR PROTECTING CRITICALLY ILL PATIENTS

#4272 ✅ Patent 9,061,046 granted on 2015-06-23
US20120015902A1
Human necessities

Arabinoxylo-oligosaccharides useful against gastrointestinal infections

#4273
US20120015903A1
Human necessities

PHARMACEUTICAL COMPOSITION FOR INHIBITING INCREASE OF IgA

#4274
US20120015904A1
Chemistry; metallurgy

BIOMARKERS FOR DIAGNOSIS OF TRANSIENT ISCHEMIC ATTACKS

#4275 ✅ Patent 8,889,698 granted on 2014-11-18
US20120015905A1
Human necessities

Compounds for the prevention and treatment of cardiovascular diseases

#4276
US20120015906A1
Chemistry; metallurgy

USES OF BORTEZOMIB IN PREDICTING SURVIVAL IN MULTIPLE MYELOMA PATIENTS

#4277 ✅ Patent 8,324,239 granted on 2012-12-04
US20120015907A1
Chemistry; metallurgy

Furopyridine compounds and uses thereof

#4278 ✅ Patent 8,524,740 granted on 2013-09-03
US20120015908A1
Chemistry; metallurgy

Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives

#4279
US20120015909A1
Chemistry; metallurgy

MAO-B INHIBITORS USEFUL FOR TREATING OBESITY

#4280 ✅ Patent 9,049,867 granted on 2015-06-09
US20120015910A1
Human necessities

Synergistic fungicidal active substance combinations

#4281 ✅ Patent 8,835,654 granted on 2014-09-16
US20120015911A1
Chemistry; metallurgy

Method and compositions for treating amyloid-related diseases

#4282 ✅ Patent 9,198,886 granted on 2015-12-01
US20120015912A1
Human necessities

Use of 2,5-dihydroxybenzene for the treatment of ocular diseases

#4283
US20120015913A1
Human necessities

Formulations of 14-EPI-Analogues of Vitamin D

#4284 ✅ Patent 9,314,474 granted on 2016-04-19
US20120015914A1
Human necessities

Formulations of 14-epi-analogues of vitamin D

#4285
US20120015915A1
Human necessities

FORMULATIONS OF 14-EPI-ANALOGUES OF VITAMIN D

#4286 ✅ Patent 8,207,149 granted on 2012-06-26
US20120015916A1
Human necessities

Method for treating secondary hyperparathyroidism in CKD

#4287
US20120015917A1
Human necessities

Use of Estrogenic Compounds in Combination with Progestogenic Compounds in Hormone-Replacement Therapy

#4288 ✅ Patent 8,420,625 granted on 2013-04-16
US20120015918A1
Human necessities

Lipolytic methods for regional adiposity

#4289
US20120015919A1
Human necessities

THERAPIES FOR TREATING CANCER USING COMBINATIONS OF COX-2 INHIBITORS AND AROMATASE INHIBITORS OR COMBINATIONS OF COX-2 INHIBITORS AND ESTROGEN RECEPTOR ANTAGONISTS

#4290 ✅ Patent 8,835,441 granted on 2014-09-16
US20120015920A1
Chemistry; metallurgy

Heterobicyclic metalloprotease inhibitors

#4291 ✅ Patent 8,404,702 granted on 2013-03-26
US20120015921A1
Human necessities

Pharmaceutical formulations:salts of 8-[1-3,5-bis-(trifluoromethyl)phenyl)-ethoxymethyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and treatment methods using the same

#4292 ✅ Patent 8,293,783 granted on 2012-10-23
US20120015922A1
Human necessities

Use of artemisinin derivatives for the treatment of asthma and chronic obstructive pulmonary disease (COPD)

#4293
US20120015923A1
Human necessities

USE OF ANDROGRAPHOLIDE COMPOUNDS FOR TREATING INFLAMMATION AND AIRWAY DISORDERS

#4294 ✅ Patent 9,724,664 granted on 2017-08-08
US20120015924A1
Performing operations; transporting

Spray-drying process

#4295
US20120015925A1
Chemistry; metallurgy

NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS

#4296 ✅ Patent 8,569,336 granted on 2013-10-29
US20120015926A1
Chemistry; metallurgy

Compounds for the treatment of inflammatory disorders

#4297 ✅ Patent 8,748,603 granted on 2014-06-10
US20120015927A1
Chemistry; metallurgy

Crystalline forms of N-[2-[[(2,3-difluorophenyl)methyl]THIO]-6-{[(1R,2S)-2,3-dihydroxy-1-methylpropyl]oxy}-4-pyrimidinyl]-1-azetidinesulfonamide

#4298 ✅ Patent 9,126,927 granted on 2015-09-08
US20120015928A1
Chemistry; metallurgy

Amido compounds and their use as pharmaceuticals

#4299 ✅ Patent 8,338,467 granted on 2012-12-25
US20120015929A1
Chemistry; metallurgy

Compounds as cannabinoid receptor ligands

#4300 ✅ Patent 8,835,422 granted on 2014-09-16
US20120015930A1
Chemistry; metallurgy

Substituted imidazoheterocycle derivatives

#4301 ✅ Patent 8,293,736 granted on 2012-10-23
US20120015931A1
Chemistry; metallurgy

Purine compounds selective for PI3K P110 delta, and methods of use

#4302 ✅ Patent 8,357,716 granted on 2013-01-22
US20120015932A1
Chemistry; metallurgy

Pyrazole derivatives used as CCR4 receptor antagonists

#4303 ✅ Patent 8,609,681 granted on 2013-12-17
US20120015933A1
Chemistry; metallurgy

Spirocyclic nitriles as protease inhibitors

#4304 ✅ Patent 8,293,760 granted on 2012-10-23
US20120015934A1
Chemistry; metallurgy

Cyclopamine lactam analogs and methods of use thereof

#4305 ✅ Patent 8,293,892 granted on 2012-10-23
US20120015935A1
Chemistry; metallurgy

Substituted tetrahydropyrazolo-pyrido-azepine compounds

#4306 ✅ Patent 8,841,290 granted on 2014-09-23
US20120015936A1
Chemistry; metallurgy

Substituted tetrahydronaphthalenes, method for the production thereof, and use thereof as drugs

#4307 ✅ Patent 9,096,542 granted on 2015-08-04
US20120015937A1
Chemistry; metallurgy

Kinase inhibitors and their uses

#4308
US20120015938A1
Chemistry; metallurgy

1,4-BENZODIAZEPIN-2-ON DERIVATIVES

#4309
US20120015939A1
Human necessities

TOPICAL TREATMENT OF NEUROPATHIC PAIN AND METHODS OF DIAGNOSIS

#4310 ✅ Patent 8,263,632 granted on 2012-09-11
US20120015940A1
Chemistry; metallurgy

Aminopyridine derivatives having Aurora A selective inhibitory action

#4311 ✅ Patent 8,148,380 granted on 2012-04-03
US20120015941A1
Chemistry; metallurgy

Antibacterial amide and sulfonamide substituted heterocyclic urea compounds

#4312
US20120015942A1
Chemistry; metallurgy

SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF

#4313
US20120015943A1
Chemistry; metallurgy

SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF

#4314 ✅ Patent 8,841,336 granted on 2014-09-23
US20120015944A1
Chemistry; metallurgy

Tetrazole-substituted arylamides as P2Xand P2Xantagonists

#4315 ✅ Patent 9,238,027 granted on 2016-01-19
US20120015945A1
Human necessities

Use of CB1 antagonists and/or inverse agonists for the preparation of drugs that increase motor neuron excitability

#4316 ✅ Patent 8,980,892 granted on 2015-03-17
US20120015946A1
Chemistry; metallurgy

Insecticidal compounds

#4317
US20120015947A1
Chemistry; metallurgy

Cyclic hydroxylamine as psychoactive compounds

#4318
US20120015948A1
Chemistry; metallurgy

TABLET COMPOSITION

#4319
US20120015949A1
Human necessities

COMPOSITION AND METHOD OF DECREASING RENAL ISCHEMIC DAMAGE

#4320 ✅ Patent 8,716,289 granted on 2014-05-06
US20120015950A1
Chemistry; metallurgy

Carbamate derivatives of alkyl-heterocycles, preparation thereof and therapeutic use thereof

#4321 ✅ Patent 8,420,648 granted on 2013-04-16
US20120015951A1
Performing operations; transporting

Polymorphs of brimonidine pamoate

#4322 ✅ Patent 8,629,164 granted on 2014-01-14
US20120015952A1
Chemistry; metallurgy

Inhibitors of NF-κB

#4323
US20120015953A1
Human necessities

METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALLERGY

#4324 ✅ Patent 8,604,037 granted on 2013-12-10
US20120015954A1
Chemistry; metallurgy

Therapeutic agents useful for treating pain

#4325 ✅ Patent 8,592,440 granted on 2013-11-26
US20120015955A1
Chemistry; metallurgy

Crystalline form I of imatinib mesylate

#4326
US20120015956A1
Chemistry; metallurgy

DEUTERIUM-ENRICHED DASATINIB

#4327
US20120015957A1
Chemistry; metallurgy

PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR

#4328 ✅ Patent 8,759,352 granted on 2014-06-24
US20120015958A1
Chemistry; metallurgy

1-(4-ureidobenzoyl)piperazine derivatives

#4329 ✅ Patent 8,841,324 granted on 2014-09-23
US20120015959A1
Chemistry; metallurgy

Heterocyclic compounds as autotaxin inhibitors

#4330
US20120015960A1
Physics

CHEMICAL INHIBITOR OF P53-SNAIL BINDING AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER DISEASE CONTAINING SAME AS ITS ACTIVE INGREDIENT

#4331
US20120015961A1
Chemistry; metallurgy

ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY

#4332
US20120015962A1
Chemistry; metallurgy

PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

#4333 ✅ Patent 8,637,529 granted on 2014-01-28
US20120015963A1
Chemistry; metallurgy

Pyrazolo[3,4-]pyrimidine compounds

#4334
US20120015964A1
Chemistry; metallurgy

QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA

#4335
US20120015965A1
Human necessities

PHARMACEUTICAL COMPOSITION COMPRISING N-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY] PHENYL]-6-[5[[[2-(METHYLSULFONYL) ETHYL]AMINO]METHYL]-2-FURYL]-4- QUINAZOLINAMINE

#4336
US20120015966A1
Chemistry; metallurgy

PPAR ACTIVE COMPOUNDS

#4337
US20120015967A1
Human necessities

PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS

#4338
US20120015968A1
Human necessities

USE OF PYRIMIDYLAMINOBENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE LEUCINE ZIPPER-AND STERILE ALPHA MOTIF-CONTAINING KINASE (ZAK)

#4339 ✅ Patent 8,367,690 granted on 2013-02-05
US20120015969A1
Human necessities

Aminopyridine derivatives having aurora a selective inhibitory action

#4340 ✅ Patent 8,470,843 granted on 2013-06-25
US20120015970A1
Chemistry; metallurgy

Azacyclic compounds

#4341
US20120015971A1
Human necessities

OPHTHALMIC COMPOSITION COMPRISING ASCOMYCIN

#4342 ✅ Patent 8,748,452 granted on 2014-06-10
US20120015972A1
Chemistry; metallurgy

Indolizine derivative and use thereof for medical purposes

#4343 ✅ Patent 9,084,781 granted on 2015-07-21
US20120015973A1
Physics

MEK mutations conferring resistance to MEK inhibitors

#4344
US20120015974A1
Chemistry; metallurgy

IMIDAZOPYRIDINE INHIBITORS OF IAP

#4345 ✅ Patent 8,273,764 granted on 2012-09-25
US20120015975A1
Human necessities

Fused heterocyclic compounds and use thereof

#4346 ✅ Patent 8,329,907 granted on 2012-12-11
US20120015976A1
Chemistry; metallurgy

Autotaxin inhibitors

#4347
US20120015977A1
Chemistry; metallurgy

QUINOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS

#4348 ✅ Patent 8,633,220 granted on 2014-01-21
US20120015978A1
Chemistry; metallurgy

Therapeutic agents for ocular hypertension

#4349 ✅ Patent 8,389,546 granted on 2013-03-05
US20120015979A1
Human necessities

Compounds for modulating TRPV3 function

#4350 ✅ Patent 8,791,139 granted on 2014-07-29
US20120015980A1
Human necessities

Anthranilic diamide derivatives

#4351
US20120015981A1
Human necessities

Active compound combinations

#4352 ✅ Patent 8,389,556 granted on 2013-03-05
US20120015982A1
Human necessities

Thiazolidinedione analogues

#4353 ✅ Patent 8,633,227 granted on 2014-01-21
US20120015983A1
Human necessities

Synthesis and novel salt forms of (R)-3-((E)-pyrrolidin-3-yl)vinyl)-5-tetrahydropyran-4-yloxy)pyridine

#4354 ✅ Patent 8,383,150 granted on 2013-02-26
US20120015984A1
Human necessities

Granulate formulation of pirfenidone and pharmaceutically acceptable excipients

#4355
US20120015985A1
Human necessities

Methods of Administering Pirfenidone Therapy

#4356 ✅ Patent 9,034,943 granted on 2015-05-19
US20120015986A1
Human necessities

Salts of dehydroacetic acid as a pyrithione stabilizer in plastics

#4357 ✅ Patent 8,552,036 granted on 2013-10-08
US20120015987A1
Chemistry; metallurgy

Polymorph of atazanavir sulfate

#4358
US20120015988A1
Chemistry; metallurgy

Sulfone Compounds Which Modulate The CB2 Receptor

#4359 ✅ Patent 8,637,556 granted on 2014-01-28
US20120015989A1
Chemistry; metallurgy

Linked Myc-max small molecule inhibitors

#4360 ✅ Patent 8,501,811 granted on 2013-08-06
US20120015990A1
Chemistry; metallurgy

TASPASE1 inhibitors and their uses

#4361 ✅ Patent 8,273,780 granted on 2012-09-25
US20120015991A1
Human necessities

Polycyclic antagonists of lysophosphatidic acid receptors

#4362 ✅ Patent 8,436,207 granted on 2013-05-07
US20120015992A1
Physics

Naphthalene-based inhibitors of anti-apoptotic proteins

#4363 ✅ Patent 8,436,029 granted on 2013-05-07
US20120015993A1
Chemistry; metallurgy

Pharmaceutical forms, and methods of making and using the same

#4364 ✅ Patent 8,338,471 granted on 2012-12-25
US20120015994A1
Chemistry; metallurgy

(2,5-dioxoimidazolidin-i-yl)-n-hydroxy-acetamides as metalloproteinase inhibitors

#4365 ✅ Patent 8,383,663 granted on 2013-02-26
US20120015995A1
Human necessities

Bendamustine anionic-catioinic cyclopolysaccharide compositions

#4366 ✅ Patent 8,741,941 granted on 2014-06-03
US20120015996A1
Human necessities

Antifungal medicinal compositions

#4367
US20120015997A1
Chemistry; metallurgy

PHARMACEUTICAL COMPOSITION FOR EXTERNAL USE

#4368
US20120015998A1
Chemistry; metallurgy

PHOTOTHERAPY METHODS AND DEVICES COMPRISING EMISSIVE ARYL-HETEROARYL COMPOUNDS

#4369 ✅ Patent 8,563,593 granted on 2013-10-22
US20120015999A1
Human necessities

Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide

#4370
US20120016000A1
Human necessities

METHOD TO ASSAY PHOSPHOLIPID AND TRIGLYCERIDE TRANSFER ACTIVITY OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN

#4371 ✅ Patent 8,853,257 granted on 2014-10-07
US20120016001A1
Human necessities

Succinimide derivatives as ocular hypotensive agents

#4372
US20120016002A1
Physics

Patient Selection and Therapeutic Methods Using Markers of Prostaglandin Metabolism

#4373 ✅ Patent 8,426,379 granted on 2013-04-23
US20120016003A1
Chemistry; metallurgy

POT1 alternative splicing variants

#4374
US20120016004A1
Chemistry; metallurgy

COMPOSITIONS FOR INHIBITING GENE EXPRESSION AND USES THEREOF

#4375 ✅ Patent 8,815,818 granted on 2014-08-26
US20120016005A1
Chemistry; metallurgy

Phagocytic cell delivery of RNAI

#4376
US20120016006A1
Chemistry; metallurgy

Compositions And Methods For Increasing Cellular Uptake Of RNAi Via SID-1

#4377
US20120016007A1
Chemistry; metallurgy

SMALL INTERFERENCE RNA COMPLEX WITH INCREASED INTRACELLULAR TRANSMISSION CAPACITY

#4378 ✅ Patent 8,399,642 granted on 2013-03-19
US20120016008A1
Chemistry; metallurgy

Isolated genomic polynucleotide fragments from the p15 region of chromosome 11 encoding human ribosomal protein L26 (RIBO26)

#4379
US20120016009A1
Chemistry; metallurgy

Optimized Methods For Delivery Of DSRNA Targeting The PCSK9 Gene

#4380
US20120016010A1
Chemistry; metallurgy

RNA Interference Mediated Inhibition of BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) Gene Expression Using Short Interfering Nucleic Acid (siNA)

#4381
US20120016011A1
Chemistry; metallurgy

RNA Interference Mediated Inhibition of Connective Tissue Growth Factor (CTGF) Gene Expression Using Short Interfering Nucleic Acid (siNA)

#4382 ✅ Patent 8,524,876 granted on 2013-09-03
US20120016012A1
Human necessities

RNAi molecule targeting thymidylate synthase and application thereof

#4383 ✅ Patent 8,697,666 granted on 2014-04-15
US20120016013A1
Human necessities

Anti-cancer oligodeoxynucleotides

#4384
US20120016014A1
Human necessities

BENZOTHIOPHENE CARBOXAMIDE COMPOUNDS, COMPOSITION AND APPLICATIONS THEREOF

#4385 ✅ Patent 8,410,165 granted on 2013-04-02
US20120016015A1
Human necessities

Aldehyde conjugated flavonoid preparations

#4386 ✅ Patent 8,466,195 granted on 2013-06-18
US20120016016A1
Human necessities

Methods and compositions for treating complications of diabetes and vascular diseases using flavones

#4387
US20120016017A1
Human necessities

PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CANCER

#4388
US20120016018A1
Human necessities

COMPOSITION FOR INDUCING MULTIPLE NUCLEAR DIVISION OF CELLS

#4389
US20120016019A1
Human necessities

PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CANCER

#4390 ✅ Patent 8,697,746 granted on 2014-04-15
US20120016020A1
Human necessities

Solid dispersion of alpha-ketoamide derivatives

#4391
US20120016021A1
Human necessities

METHODS OF TREATING FRAGILE X SYNDROME, DOWN'S SYNDROME, AUTISM AND RELATED DISORDERS

#4392 ✅ Patent 8,829,045 granted on 2014-09-09
US20120016022A1
Human necessities

Agrochemical composition for pest control and pest control method

#4393 ✅ Patent 8,946,290 granted on 2015-02-03
US20120016023A1
Human necessities

Combination of selected opioids with muscarine antagonists for treating urinary incontinence

#4394
US20120016024A1
Human necessities

Water-In-Oil Emulsion Composition

#4395 ✅ Patent 8,334,120 granted on 2012-12-18
US20120016025A1
Chemistry; metallurgy

Perhydrolases for enzymatic peracid generation

#4396 ✅ Patent 8,741,373 granted on 2014-06-03
US20120016026A1
Human necessities

Compositions containing non-polar compounds

#4397
US20120016027A1
Human necessities

Composition and Method for Improved Lens Comfort

#4398 ✅ Patent 8,388,997 granted on 2013-03-05
US20120016028A1
Human necessities

Method of preparing an unsaturated fatty acid dry concentrate

#4399 ✅ Patent 8,247,602 granted on 2012-08-21
US20120016029A1
Chemistry; metallurgy

Antagonists of prostaglandin Dreceptors

#4400 ✅ Patent 8,796,336 granted on 2014-08-05
US20120016030A1
Chemistry; metallurgy

Methoxypolyethylene glycol chelate and uses thereof

#4401 ✅ Patent 8,362,082 granted on 2013-01-29
US20120016031A1
Chemistry; metallurgy

Biphenyl compound selective agonists of gamma RAR receptors

#4402 ✅ Patent 8,592,484 granted on 2013-11-26
US20120016032A1
Human necessities

Cosmetic composition containing calcium citrate and N-acylated aminoalcohol derivative to prevent dry skin and signs of cutaneous ageing

#4403 ✅ Patent 8,628,961 granted on 2014-01-14
US20120016033A1
Chemistry; metallurgy

Small molecule antagonists of phosphatidylinositol-3,4,5-triphosphate (PIP3) and uses thereof

#4404 ✅ Patent 8,252,842 granted on 2012-08-28
US20120016034A1
Chemistry; metallurgy

Polymorphic form of N-(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and uses thereof

#4405 ✅ Patent 9,023,894 granted on 2015-05-05
US20120016035A1
Human necessities

Synergistic combinations comprising a renin inhibitor for cardiovascular diseases

#4406 ✅ Patent 9,463,172 granted on 2016-10-11
US20120016036A1
Human necessities

Material and methods for treating developmental disorders including comorbid and idiopathic autism

#4407
US20120016037A1
Human necessities

Method for prevention and treatment of Alzheimers

#4408 ✅ Patent 10,322,213 granted on 2019-06-18
US20120016038A1
Human necessities

Compositions and methods for altering the rate of hydrolysis of cured oil-based materials

#4409
US20120016039A1
Human necessities

USE OF OLIVE-OIL-DERIVED COMPOUNDS AS SURFACTANTS

#4410 ✅ Patent 8,791,164 granted on 2014-07-29
US20120016040A1
Performing operations; transporting

Device and method for increasing the effectiveness processes of catalytic chemical processes

#4411 ✅ Patent 8,852,537 granted on 2014-10-07
US20120016041A1
Performing operations; transporting

Method of manufacturing a reaction vessel

#4412
US20120016042A1
Performing operations; transporting

COBALT-BASED CATALYST ON A SILICA-ALUMINA SUPPORT FOR FISCHER-TROPSCH SYNTHESIS

#4413 ✅ Patent 8,084,568 granted on 2011-12-27
US20120016043A1
Chemistry; metallurgy

Poly(arylene ether) copolymer having cation-exchange group, process of manufacturing the same, and use thereof

#4414
US20120016044A1
Chemistry; metallurgy

PROCESS TO PREPARE FLUOROPOLYMER DISPERSIONS AND MEMBRANES

#4415
US20120016045A1
Chemistry; metallurgy

Process For The Preparation Of Layered Silicates

#4416
US20120016046A1
Chemistry; metallurgy

FLAME RETARDANTS SUITABLE FOR USE IN VISCOELASTIC POLYURETHANE FOAMS

#4417
US20120016047A1
Chemistry; metallurgy

EXPANDABLE RESOL-TYPE PHENOLIC RESIN MOLDING MATERIAL, METHOD FOR PRODUCING THE SAME, AND PHENOLIC RESIN FOAM

#4418 ✅ Patent 8,598,248 granted on 2013-12-03
US20120016048A1
Chemistry; metallurgy

Flexible polyurethane foams made from alkoxylated natural oil

#4419 ✅ Patent 9,388,271 granted on 2016-07-12
US20120016049A1
Chemistry; metallurgy

Polyoxyalkylene polyol or monool and polyurethane resin

#4420
US20120016050A1
Chemistry; metallurgy

Monoisocyanate-Acrylate Monomers and Products Ulitilizing the Same

#4421 ✅ Patent 8,263,676 granted on 2012-09-11
US20120016051A1
Human necessities

Radiation and melt treated ultra high molecular weight polyethylene prosthetic devices

#4422 ✅ Patent 8,404,758 granted on 2013-03-26
US20120016052A1
Chemistry; metallurgy

Stress relaxation in crosslinked polymers

#4423
US20120016053A1
Performing operations; transporting

Cross Linked Biolaminate: Methods, Products and Applications

#4424
US20120016054A1
Human necessities

DENTURE FORMED FROM A POLYMERIZABLE DENTAL MATERIAL BASED ON METHYL METHACRYLATES AND SUITABLE FOR THE PRODUCTION OF PLASTICS FOR DENTURES

#4425 ✅ Patent 8,309,626 granted on 2012-11-13
US20120016055A1
Human necessities

Microbiocidal coatings

#4426
US20120016056A1
Chemistry; metallurgy

RUBBER COMPOSITION FOR TREAD AND PNEUMATIC TIRE

#4427 ✅ Patent 8,901,207 granted on 2014-12-02
US20120016057A1
Chemistry; metallurgy

Adhesive for electronic components

#4428 ✅ Patent 8,187,705 granted on 2012-05-29
US20120016058A1
Chemistry; metallurgy

Manganese vanadium tantalum oxide and pigments having a black metallic effect coated with the same

#4429 ✅ Patent 8,962,713 granted on 2015-02-24
US20120016059A1
Chemistry; metallurgy

Water-reducing agent for hydraulic binders

#4430 ✅ Patent 8,399,579 granted on 2013-03-19
US20120016060A1
Chemistry; metallurgy

Process for preparing an aqueous composite-particle dispersion

#4431
US20120016061A1
Chemistry; metallurgy

PROCESS TO PREPARE SELF-BINDING PIGMENT PARTICLES IMPLEMENTING ACRYLIC COMB COPOLYMERS WITH HYDROPHOBIC GROUPS AS COUPLING AGENTS, SELF BINDING PIGMENT PARTICLES AND USES THEREOF

#4432
US20120016062A1
Chemistry; metallurgy

Binder composition comprising a low viscosity naphthenic oil for coloured hot-mix asphalt applications

#4433 ✅ Patent 8,344,087 granted on 2013-01-01
US20120016063A1
Chemistry; metallurgy

Hydrosilylation cured organosiloxanes having diluent therein

#4434 ✅ Patent 8,329,793 granted on 2012-12-11
US20120016064A1
Chemistry; metallurgy

Plasticized composition comprising polyvinylbutyral resin having controlled stereochemistry

#4435 ✅ Patent 8,455,579 granted on 2013-06-04
US20120016065A1
Chemistry; metallurgy

Method for promoting crystallization of biodegradable resin composition

#4436 ✅ Patent 8,569,407 granted on 2013-10-29
US20120016066A1
Performing operations; transporting

Biodegradable material composed of a polymer comprising a porous metal-organic framework

#4437
US20120016067A1
Chemistry; metallurgy

RESIN COMPOSITION FOR SOLAR CELL-SEALING MATERIAL

#4438 ✅ Patent 8,557,912 granted on 2013-10-15
US20120016068A1
Chemistry; metallurgy

Thermoplastic resin composition

#4439 ✅ Patent 8,907,010 granted on 2014-12-09
US20120016069A1
Chemistry; metallurgy

Fast setting sheet fed offset inks with non-aqueous dispersion polymers

#4440
US20120016070A1
Chemistry; metallurgy

SURFACTANT COMPRISING FLUORINE-CONTAINING POLYMER

#4441
US20120016071A1
Chemistry; metallurgy

POLYFUNCTIONAL (METH)ACRYLIC POLYMER, COATING COMPOSITION, PROCESS FOR PRODUCING A COATING AND COATED ARTICLE

#4442 ✅ Patent 8,569,439 granted on 2013-10-29
US20120016072A1
Chemistry; metallurgy

Hardener for silicone rubber materials

#4443 ✅ Patent 8,716,426 granted on 2014-05-06
US20120016073A1
Chemistry; metallurgy

Method for preparing an allophanate, allophanate, and low-viscosity composition containing the allophanate

#4444 ✅ Patent 9,550,857 granted on 2017-01-24
US20120016074A1
Chemistry; metallurgy

High-functionality polyisocyanates containing urethane groups

#4445 ✅ Patent 9,200,179 granted on 2015-12-01
US20120016075A1
Chemistry; metallurgy

Polyurethane dispersion and method for producing the same

#4446 ✅ Patent 9,133,353 granted on 2015-09-15
US20120016076A1
Chemistry; metallurgy

Low temperature curable polyimide resin and method of preparing the same

#4447
US20120016077A1
Chemistry; metallurgy

POLYAMIDE RESIN, POLYAMIDE RESIN COMPOSITION, AND MOLDED ARTICLE COMPRISING SAME

#4448 ✅ Patent 8,883,905 granted on 2014-11-11
US20120016078A1
Chemistry; metallurgy

Method of manufacturing powder coating composition

#4449 ✅ Patent 8,648,212 granted on 2014-02-11
US20120016079A1
Chemistry; metallurgy

Process for preparing solutions of radiation-sensitive, free-radically polymerizable organic compounds

#4450
US20120016080A1
Chemistry; metallurgy

INITIATORS FOR POLYMERIZATION OF VINYL MONOMERS BASED ON THE REACTION OF PHENOXYALUMINUM COMPLEXES WITH OXYGEN

#4451 ✅ Patent 8,492,478 granted on 2013-07-23
US20120016081A1
Chemistry; metallurgy

Curable perfluoropolyether gel composition and gel product produced by using cured perfluoropolyether gel composition

#4452 ✅ Patent 8,445,612 granted on 2013-05-21
US20120016082A1
Chemistry; metallurgy

Conjugation reactions

#4453 ✅ Patent 8,344,075 granted on 2013-01-01
US20120016083A1
Chemistry; metallurgy

Hybrid siloxane polymer, encapsulant obtained from the siloxane polymer, and electronic device including the encapsulant

#4454 ✅ Patent 9,175,143 granted on 2015-11-03
US20120016084A1
Chemistry; metallurgy

Method for producing particulate water-absorbent resin

#4455 ✅ Patent 8,431,113 granted on 2013-04-30
US20120016085A1
Chemistry; metallurgy

Polymer conjugates

#4456 ✅ Patent 8,853,329 granted on 2014-10-07
US20120016086A1
Chemistry; metallurgy

Adhesives made from polymer systems

#4457 ✅ Patent 8,450,422 granted on 2013-05-28
US20120016087A1
Chemistry; metallurgy

Polyolefin masterbatch and composition suitable for injection molding

#4458 ✅ Patent 8,710,155 granted on 2014-04-29
US20120016088A1
Chemistry; metallurgy

Process for brominating unsaturated organic compounds with removal of quaternary ammonium or quaternary phosphonium monochlorides

#4459 ✅ Patent 9,023,963 granted on 2015-05-05
US20120016089A1
Chemistry; metallurgy

Process for production of fluorine-containing polymers and fluorine-containing polymers

#4460
US20120016090A1
Chemistry; metallurgy

PROCESS FOR INCREASING THE MOLECULAR WEIGHT OF POLYESTERS

#4461
US20120016091A1
Chemistry; metallurgy

Halogenated Butyl Rubber Having Superior Reactivity

#4462
US20120016092A1
Chemistry; metallurgy

Catalysts based on quinoline precursors

#4463 ✅ Patent 8,288,576 granted on 2012-10-16
US20120016093A1
Performing operations; transporting

Recyclable ruthenium catalysts for metathesis reactions

#4464 ✅ Patent 8,545,225 granted on 2013-10-01
US20120016094A1
Human necessities

Redox-curing type composition

#4465 ✅ Patent 8,796,492 granted on 2014-08-05
US20120016095A1
Chemistry; metallurgy

α-(unsaturated alkoxyalkyl) acrylate composition and process for production thereof

#4466 ✅ Patent 8,362,181 granted on 2013-01-29
US20120016096A1
Performing operations; transporting

Functional polymers prepared with sulfur-containing initiators

#4467 ✅ Patent 8,227,653 granted on 2012-07-24
US20120016097A1
Chemistry; metallurgy

Olefin oligomerization reaction processes exhibiting reduced fouling

#4468 ✅ Patent 8,344,099 granted on 2013-01-01
US20120016098A1
Chemistry; metallurgy

Steaming of a polyolefin

#4469 ✅ Patent 8,541,530 granted on 2013-09-24
US20120016099A1
Chemistry; metallurgy

Method of manufacturing artificial snow

#4470 ✅ Patent 8,399,598 granted on 2013-03-19
US20120016100A1
Chemistry; metallurgy

Copolycarbonate and process for producing the same

#4471
US20120016101A1
Performing operations; transporting

POLYLACTIDE RESIN AND PREPARATION METHOD THEREOF

#4472 ✅ Patent 8,454,977 granted on 2013-06-04
US20120016102A1
Human necessities

Non-toxic biofilm inhibitor

#4473 ✅ Patent 8,809,498 granted on 2014-08-19
US20120016103A1
Chemistry; metallurgy

Pepstatin A derivatives

#4474 ✅ Patent 8,153,114 granted on 2012-04-10
US20120016104A1
Chemistry; metallurgy

Hyperglycosylated mammalian IL-7 IgG conjugate composition

#4475
US20120016105A1
Human necessities

PURIFICATION OF PEPTIDE CONJUGATES BY HYDROPHOBIC INTERACTION CHROMATOGRAPHY

#4476 ✅ Patent 8,372,625 granted on 2013-02-12
US20120016106A1
Chemistry; metallurgy

Polynucleotides encoding antagonist antibodies against GDF-8

#4477
US20120016107A1
Chemistry; metallurgy

GROWTH FACTOR HTTER36

#4478 ✅ Patent 8,519,105 granted on 2013-08-27
US20120016108A1
Chemistry; metallurgy

Compositions and methods for treating kidney disease

#4479 ✅ Patent 8,263,738 granted on 2012-09-11
US20120016109A1
Chemistry; metallurgy

Estrogen receptors and methods of use

#4480 ✅ Patent 8,299,227 granted on 2012-10-30
US20120016110A1
Performing operations; transporting

Method of immobilizing and stretching a nucleic acid on a substrate

#4481
US20120016111A1
Physics

Compositions for the treatment of cancer, and methods for testing and using the same

#4482
US20120016112A1
Chemistry; metallurgy

PROCESSING OF MACRONUTRIENTS

#4483 ✅ Patent 8,932,843 granted on 2015-01-13
US20120016113A1
Chemistry; metallurgy

Buoyant protein harvesting method

#4484
US20120016114A1
Chemistry; metallurgy

PROCESS FOR THE PREPARATION OF MONOETHYLENICALLY UNSATURATED GLYCOSYLAMINES

#4485
US20120016115A1
Performing operations; transporting

APPARATUS FOR MANUFACTURING GEL PARTICLE AND METHOD FOR MANUFACTURING GEL PARTICLE

#4486 ✅ Patent 8,633,188 granted on 2014-01-21
US20120016116A1
Chemistry; metallurgy

Aminodihydrothiazine derivatives

#4487
US20120016117A1
Chemistry; metallurgy

INDAZOLEPROPIONIC ACID AMIDE COMPOUND

#4488 ✅ Patent 8,129,524 granted on 2012-03-06
US20120016118A1
Chemistry; metallurgy

Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same

#4489
US20120016119A1
Human necessities

NOVEL PYRROLO(2,3-d)PYRIMIDINE COMPOUND

#4490 ✅ Patent 8,648,190 granted on 2014-02-11
US20120016120A1
Chemistry; metallurgy

Process for producing 2-hydroxymethylmorpholine salt

#4491 ✅ Patent 8,895,732 granted on 2014-11-25
US20120016121A1
Chemistry; metallurgy

Process for the separation of enantiomers of 3,6-dihydro-1,3,5-triazine derivatives

#4492 ✅ Patent 8,530,656 granted on 2013-09-10
US20120016122A1
Chemistry; metallurgy

Compositions and methods for inhibition of the JAK pathway

#4493 ✅ Patent 8,642,760 granted on 2014-02-04
US20120016123A1
Chemistry; metallurgy

Low hygroscopic aripiprazole drug substance and processes for the preparation thereof

#4494
US20120016124A1
Chemistry; metallurgy

SEROTONIN REUPTAKE INHIBITORS

#4495
US20120016125A1
Chemistry; metallurgy

METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE

#4496 ✅ Patent 8,598,347 granted on 2013-12-03
US20120016126A1
Chemistry; metallurgy

Method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate

#4497 ✅ Patent 8,338,600 granted on 2012-12-25
US20120016127A1
Chemistry; metallurgy

Copper-oxygen adduct complexes, and methods of making and use

#4498
US20120016128A1
Chemistry; metallurgy

Rhodamine lactone phosphoramidites and polymers

#4499 ✅ Patent 8,487,105 granted on 2013-07-16
US20120016129A1
Chemistry; metallurgy

Process for preparing pitavastatin, intermediates and pharmaceuctically acceptable salts thereof

#4500 ✅ Patent 8,754,225 granted on 2014-06-17
US20120016130A1
Chemistry; metallurgy

Process for preparing a biphenyl-2-ylcarbamic acid