TROJAN CIRCULATING TUMOR CELLS

Engineers have developed a method to modify circulating tumor cells to produce immune-stimulating or anti-cancer exosomes. These modified cells can be infused into a patient to target and attack primary tumors and metastatic lesions. Additionally, the method involves creating exosome-loaded dendritic cells to trigger a systemic immune response in the patient. This innovative approach allows for infiltration into solid tumors using specialized "trojan" cells that are designed to bypass the body's natural defenses. The goal is to overcome challenges in immunotherapy by enhancing the body's ability to fight cancer effectively.

PRIVACY-PRESERVING MOBILITY AS A SERVICE SUPPORTED BY BLOCKCHAIN

A communication network node has been developed to protect user privacy and support a service called Mobility as a Service (MaaS) using blockchain technology. This node separates sensitive user data from non-sensitive data and only shares the non-sensitive data with the distributed ledger. The invention is based on the concept of distributed ledgers, like blockchain, which record digital transactions across multiple nodes or devices. MaaS is a service where users can access different transportation options without owning a vehicle, combining public and private transportation services. Traditional MaaS solutions usually rely on a central gateway for trip planning and payment processing.

Nant COVID Vaccine Cross Reactivity

A new type of COVID vaccine has been created that not only targets the current SARS-CoV2 virus but also shows effectiveness against other coronaviruses like SARS-CoV1, MERS-CoV, OC43-CoV, and HKU1-CoV. This vaccine has been found to stimulate the production of memory B cells and T cells that can recognize and fight off a wide range of coronaviruses. The technology behind this vaccine is based on recombinant methods, which involve manipulating genetic material to create desired immune responses. The research and development of this vaccine have been ongoing, building upon previous patent applications to improve its effectiveness and cross-reactivity. This innovative vaccine holds promise for providing broader protection against various coronaviruses in the future.

SENOLYTIC CRISPR CAR T CELLS PRODUCED BY CRISPR-CAS9 GENOME EDITING

Using CRISPR-Cas9 and DNA templates, chimeric antigen receptors (CARs) can be created on T cells to target a protein called urokinase Plasminogen Activator Receptor (uPAR) found on senescent cells. These engineered CAR T cells can be used to treat conditions like neurodegenerative diseases, stroke, head trauma, accidents, and aging-related issues in older individuals. The invention was supported by a grant from the National Institutes of Health. Senescent cells, which stop dividing in response to stress, can cause tissue dysfunction if not cleared properly by the immune system. This technology aims to enhance the immune response against these problematic cells for better tissue health.

Mid-Air Haptic Textures

Using mid-air ultrasonic technology, this invention adds texture to virtual and holographic objects that can be felt by users. It extracts features from images and computes textural qualities like roughness to create haptic textures. These textures are projected onto the user's hands as they interact with holographic objects. The technology allows users to physically explore virtual objects in digital environments. To enhance user immersion, a study is being conducted to align user expectations with the rendered tactile textures.

Female Universal Condom Device

This invention is a female condom device that helps women stay safe during sex. It combines a dental dam and a male condom in one device. The dental dam is a thin sheet of latex or nitrile that stays outside the vagina. The male condom part goes inside the vagina during intercourse. The device has adhesive to keep it in place and reduce the risk of transmitting infections or causing pregnancy. Overall, this invention aims to protect women's health during sexual activity.

DIRECTIONAL PADS WITH DYNAMIC TACTILE FEATURES AND METHODS OF USING THE SAME

A directional pad for a controller has a top shell with openings and movable protrusions. These protrusions can be retracted or deployed through the openings by actuators. The invention is designed to enhance user interaction with controllers, especially in gaming applications. By providing dynamic tactile feedback, users can have a more immersive and responsive experience. This innovation aims to overcome the limitations of traditional directional pads by offering more versatile input options in a compact handheld controller design.

ELECTRONIC DEVICE

An electronic device has three display panels that can be stacked or tiled side by side. This device includes an expansion mechanism that moves the panels to switch between stacking and tiling states. In the tiling state, the panels are arranged next to each other in one direction with the third panel under the first two. In the stacking state, the panels are placed on top of each other in a different direction. This invention offers a new way to expand screens without relying on flexible screens, which can be costly and limiting in development.

BIRDS FOR PRODUCING FEMALE HATCHLING AND METHODS OF PRODUCING SAME

A new method has been developed to create genetically modified female birds. These birds, when bred with male birds, will only produce female offspring. This invention is important for commercial poultry farming, where sex separation is crucial for efficient meat and egg production. Currently, billions of male chicks are culled each year in the industry, as they are not useful for meat or egg production. By selectively breeding female birds, this method aims to reduce unnecessary culling and improve overall productivity in the poultry industry.

RADIOIMMUNOCONJUGATES TARGETING CALRETICULIN FOR USE IN THE TREATMENT OF CANCER

A new method has been developed to treat cancer and precancerous conditions using a radiolabeled agent that targets calreticulin on the surface of cells. This agent delivers radiation specifically to cells with calreticulin, like tumor cells, reducing their numbers and nearby malignant cells to shrink the tumor. The radiation from the agent also boosts calreticulin expression on cell surfaces, causing more of the agent to accumulate at the target site for better treatment outcomes. Calreticulin levels rise on cell surfaces when there is damage or stress, making this method useful in combination with other anticancer treatments to enhance their effectiveness. By targeting calreticulin, this innovative approach shows promise in improving cancer therapy.