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Assignee profile:

EISAI R&D MANAGEMENT CO., LTD.

City:

Tokyo

Country:

Japan

Published Applications:

577

Last publication date:

2026-05-14

Patent Grants:

477

Last grant date:

2026-01-06

Quarterly EISAI R&D MANAGEMENT CO., LTD. Patent Applications

Top Inventors for applications by EISAI R&D MANAGEMENT CO., LTD.

These are the the leading inventors for applications assigned to EISAI R&D MANAGEMENT CO., LTD.:

Francis G. Fang 44 Andover, MA United States
Hyeong wook Choi 33 Andover, MA United States
Charles E. Chase 25 Londonderry, NH United States
Keigo Tanaka 24 Tsukuba, Japan

Atsushi Endo 23 Andover, MA United States
Koichi ITO 19 Tsukuba, Japan
Mamoru Takaishi 19 Tsukuba, Japan
Keigo TANAKA 18 Tsukuba-shi, Japan

Sudeep Prajapati 18 Somerville, MA United States
Ming-Hong Hao 17 Quincy, MA United States
Noritaka Kitazawa 17 Tsukuba, Japan
Dae-Shik Kim 17 Andover, MA United States

Toshihiko Kaneko 16 Tsukuba, Japan
John Wang 16 Andover, MA United States
Junji Matsui 15 Tsukuba, Japan
Dominic Reynolds 15 Stoneham, MA United States

Nobuaki Sato 14 Tsukuba, Japan
Shawn Schiller 13 Haverhill, MA United States
Koki Kawano 13 Tsukuba, Japan
Xiang Liu 13 Winchester, MA United States

Kazutaka Nakamoto 13 Tsukuba, Japan
Kazutaka Nakamoto 13 Tsukuba-shi, Japan
Kazunobu Kira 12 Tsukuba-Shi, Japan
Takeo Sasaki 12 Tsukuba, Japan

Atsushi Endo 12 Boston, MA United States
James PALACINO 12 Wellesley, MA United States
Lynn Hawkins 12 Concord, MA United States
Kazunobu Kira 12 Tsukuba, Japan

Teiji KIMURA 12 Tsukuba, Japan
Jared Spidel 12 Downingtown, PA United States
Huiming Zhang 11 Andover, MA United States
Francis Fang 11 Andover, MA United States

Hiroaki Hagiwara 11 Tsukuba, Japan
Eriko DOI 11 Tsukuba, Japan
Takashi Satoh 11 Andover, MA United States
Silvia Buonamici 11 Boston, MA United States

Jing LI 11 Andover, MA United States
Andrew Cook 10 Stow, MA United States
Katsura Hata 10 Tsukuba-shi, Japan
Shuji Shirotori 10 Tsukuba-shi, Japan

Norio Murai 10 Tsukuba, Japan
Sally Ishizaka 10 Weston, MA United States
Lihua Yu 10 Acton, MA United States
Shuji Shirotori 10 Tsukuba, Japan

Frank Fang 10 Andover, MA United States
Guo Zhu Zheng 10 Lexington, MA United States
Hans Hansen 10 Somerville, MA United States
Kunitoshi Takeda 10 Tsukuba, Japan

Yu Yoshida 10 Tsukuba, Japan
Matthew Mackey 10 Melrose, MA United States
Kristen Sanders 9 Gilmanton, NH United States
Mark Spyvee 9 Hampstead, NH United States

Ermira Pazolli 9 Wayland, MA United States
Wanjun Zheng 9 Londonderry, NH United States
Thiwanka SAMARAKOON 9 Westwood, MA United States
Naoaki Watanabe 9 Tsukuba-shi, Japan

Shinsuke Hirota 9 Tsukuba, Japan
Jaemoon Lee 9 Andover, MA United States
Yasuhiro Funahashi 9 Tsukuba, Japan
Takehiko MIYAGAWA 9 Tsukuba, Japan

Arani Chanda 9 Malden, MA United States
Eiji Inoue 9 Kobe, Japan
Yimin Jiang 9 Londonderry, NH United States
Yoichi Kita 9 Tsukuba, Japan

Yoshito Kishi 9 Cambridge, MA United States
Shelby ELLERY 9 Boston, MA United States
Takafumi Motoki 9 Tsukuba, Japan
Kogyoku Shin 8 Tsukuba, Japan

Hiroshi Obaishi 8 Tsukuba-shi, Japan
Kenzo Muramoto 8 Tsukuba, Japan
Satoshi Inoue 8 Tsukuba, Japan
Kappei Tsukahara 8 Tsukuba-shi, Japan

Eric Carlson 8 Merrimack, NH United States
Tomohiro Matsushima 8 Tsukuba, Japan
Itaru Tsukada 8 Ushiku-shi, Japan
Yoshinori Takahashi 8 Tsukuba, Japan

Motohiro Soejima 8 Tsukuba, Japan
Kevin Wayne Kuntz 8 Woburn, MA United States
EISAI R&D MANAGEMENT CO., LTD. 8 Tokyo, Japan
Masayuki Matsukura 8 Tsukuba, Japan

Toshio Imai 8 Kobe, Japan
Yuichi Ono 8 Kobe, Japan
Ping ZHU 8 Acton, MA United States
Masayuki Matsukura 8 Tsukuba-shi, Japan

Atsushi Kamada 8 Tsukuba, Japan
Tasuku Ishida 8 Tsukuba, Japan
Katsura Hata 8 Tsukuba, Japan
Yusuke Ayata 7 Kamisu, Japan

Xingfeng BAO 7 Concord, MA United States
Jun Niijima 7 Tsukuba, Japan
Peter Smith 7 Arlington, MA United States
Taro Semba 7 Tsukuba, Japan

Yuji Yamamoto 7 Ibaraki, Japan
Tomohiro Matsushima 7 Tsukuba-shi, Japan
Toshio Imai 7 Kyoto, Japan
Yongbo HU 7 Malden, MA United States

Yoshihiko Norimine 7 Tsukuba, Japan
Takao OMAE 7 Tsukuba, Japan
Taichi Abe 7 Kamisu, Japan
Norio Murai 7 Tsukuba-shi, Japan

Recent patent applications by EISAI R&D MANAGEMENT CO., LTD.

EISAI R&D MANAGEMENT CO., LTD. based in Tokyo, JP has been assigned the rights to these inventions. The list includes both Pending Applications and Patent Grants:

#1 | 2026-05-14

US20260132144A1

Chemistry; metallurgy

METHOD FOR SYNTHESIS OF DIAZABICYCLO[6.2.0]DECANE RELATED COMPOUNDS

#2 | 2025-10-30

US20250333400A1

Chemistry; metallurgy

CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE

#3 | 2025-10-09

US20250313887A1

Chemistry; metallurgy

SUPPRESSION OF TARGETED APTAMER CLUSTER

#4 | 2025-05-29

US20250171475A1

Chemistry; metallurgy

CHIRAL REAGENTS FOR PREPARATION OF HOMOGENEOUS OLIGOMERS

#5 | 2025-03-20

US20250092392A1

Chemistry; metallurgy

ANTISENSE OLIGONUCLEOTIDES AND THEIR USE FOR TREATMENT OF NEURODEGENERATIVE DISORDERS

#6 | 2025-02-27

US20250064802A1

Human necessities

METHODS OF TREATING IRREGULAR SLEEP-WAKE RHYTHM DISORDER AND CIRCADIAN RHYTHM SLEEP DISORDERS ASSOCIATED WITH NEURODEGENERATIVE DISEASES

#7 | 2024-11-07

US20240368140A1

Chemistry; metallurgy

CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE

#8 | 2024-10-31 ✅ Patent 12,514,926 granted on 2026-01-06

US20240360108A1

Chemistry; metallurgy

SPLICING MODULATOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE

#9 | 2024-09-19

US20240309014A1

Chemistry; metallurgy

MACROCYCLIC COMPOUNDS AND USES THEREOF

#10 | 2024-07-04 ✅ Patent 12,384,824 granted on 2025-08-12

US20240218035A1

Chemistry; metallurgy

Method for Producing an Active Hepatocyte Growth Factor (HGF)

#11 | 2024-02-15 ✅ Patent 12,447,173 granted on 2025-10-21

US20240050462A1

Human necessities

PHARMACEUTICAL COMPOSITION CONTAINING DOUBLE-STRANDED RIBONUCLEIC ACID INHIBITING EXPRESSION OF COMPLEMENT C5

#12 | 2023-12-21 ✅ Patent 12,421,248 granted on 2025-09-23

US20230406863A1

Chemistry; metallurgy

MACROCYCLIC COMPOUND AND USES THEREOF

#13 | 2023-12-14 ✅ Patent 12,630,544 granted on 2026-05-19

US20230399323A1

Chemistry; metallurgy

NOVEL COMPOUND, a-SYNUCLEIN AGGREGATE BINDER, AND USE THEREOF

#14 | 2023-09-28 ✅ Patent 12,622,905 granted on 2026-05-12

US20230301990A1

Human necessities

CERTAIN ARYL PLADIENOLIDE COMPOUNDS AND METHODS OF USE

#15 | 2023-08-10

US20230250182A1

Chemistry; metallurgy

METHODS FOR TREATING CANCER OR VON-HIPPEL LINDAU DISEASE USING A COMBINATION OF A PD-1 ANTAGONIST, A HIF-2 ALPHA INHIBITOR, AND LENVATINIB OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

#16 | 2023-07-06

US20230212679A1

Chemistry; metallurgy

Method for Predicting Effectiveness of Angiogenesis Inhibitor

#17 | 2023-07-06 ✅ Patent 12,564,641 granted on 2026-03-03

US20230212310A1

Human necessities

ERIBULIN ANTIBODY-DRUG CONJUGATES AND METHODS OF USE

#18 | 2023-07-06

US20230210838A1

Human necessities

METHODS FOR TREATING CANCER OR VON-HIPPEL LINDAU DISEASE USING A COMBINATION OF A HIF-2 ALPHA INHIBITOR AND LENVATINIB

#19 | 2023-05-04 ✅ Patent 12,251,386 granted on 2025-03-18

US20230140327A1

Human necessities

Salt form of a human histone methyltransferase EZH2 inhibitor

#20 | 2023-04-27

US20230128195A1

Chemistry; metallurgy

SYNTHESIS OF HALICHONDRINS

#21 | 2023-04-13 ✅ Patent 12,545,894 granted on 2026-02-10

US20230114089A1

Chemistry; metallurgy

METHOD FOR INDUCING DOPAMINERGIC NEURON PROGENITOR CELLS

#22 | 2023-03-02 ✅ Patent 12,606,541 granted on 2026-04-21

US20230062861A1

Chemistry; metallurgy

PPARg MODULATORS AND METHODS OF USE

#23 | 2023-01-19 ✅ Patent 11,814,398 granted on 2023-11-14

US20230016686A1

Chemistry; metallurgy

Macrocyclic compounds and uses thereof

#24 | 2022-12-01 ✅ Patent 11,945,807 granted on 2024-04-02

US20220380352A1

Chemistry; metallurgy

Splicing modulator antibody-drug conjugates and methods of use

#25 | 2022-12-01

US20220378706A1

Human necessities

PHARMACEUTICAL COMPOSITION COMPRISING PDE9 INHIBITOR

#26 | 2022-09-29 ✅ Patent 12,564,600 granted on 2026-03-03

US20220304982A1

Human necessities

SYSTEM FOR ENHANCING THERAPEUTIC COMPLIANCE OF THE ANTI-CANCER COMPOUND E7766

#27 | 2022-08-25

US20220267393A1

Chemistry; metallurgy

A Method for Producing An Active Hepatocyte Growth Factor (HGF)

#28 | 2022-06-23

US20220195437A1

Chemistry; metallurgy

TAU-TARGETING OLIGONUCLEOTIDE GAPMERS

#29 | 2022-06-23 ✅ Patent 12,479,819 granted on 2025-11-25

US20220194925A1

Chemistry; metallurgy

METHOD AND COMPOUND USEFUL IN PREPARATION OF OREXIN-2 RECEPTOR ANTAGONIST, AND LEMBOREXANT HAVING FEW IMPURITIES

#30 | 2022-04-21 ✅ Patent 12,036,204 granted on 2024-07-16

US20220117933A1

Human necessities

Pharmaceutical composition for treating tumor

#31 | 2022-04-14 ✅ Patent 12,421,246 granted on 2025-09-23

US20220112207A1

Chemistry; metallurgy

METHOD FOR SYNTHESIS OF DIAZABICYCLO[6.2.0]DECANE RELATED COMPOUNDS

#32 | 2022-03-24 ✅ Patent 12,214,050 granted on 2025-02-04

US20220088212A1

Human necessities

C-terminal lysine conjugated immunoglobulins

#33 | 2022-03-17 ✅ Patent 12,043,670 granted on 2024-07-23

US20220081486A1

Chemistry; metallurgy

Anti-BCMA antibody-drug conjugates and methods of use

#34 | 2022-03-10 ✅ Patent 11,707,448 granted on 2023-07-25

US20220071959A1

Human necessities

Combination therapies for the treatment of cancer

#35 | 2022-02-17

US20220048862A1

Chemistry; metallurgy

High-Purity Quinoline Derivative and Method for Manufacturing Same

#36 | 2022-02-10 ✅ Patent 12,226,409 granted on 2025-02-18

US20220040168A1

Human necessities

Treatment of hepatocellular carcinoma

#37 | 2022-02-03 ✅ Patent 12,514,928 granted on 2026-01-06

US20220031859A1

Human necessities

HERBOXIDIENE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE

#38 | 2022-01-27 ✅ Patent 12,083,112 granted on 2024-09-10

US20220023285A1

Human necessities

Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer

#39 | 2022-01-27 ✅ Patent 12,303,499 granted on 2025-05-20

US20220023275A1

Human necessities

Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds

#40 | 2022-01-20 ✅ Patent 11,479,552 granted on 2022-10-25

US20220017517A1

Chemistry; metallurgy

Substituted piperidine compounds and their use

#41 | 2021-11-11 ✅ Patent 11,434,246 granted on 2022-09-06

US20210347779A1

Chemistry; metallurgy

EP4 antagonists

#42 | 2021-11-11 ✅ Patent 11,998,544 granted on 2024-06-04

US20210346371A1

Human necessities

Methods of using splicing modulators

#43 | 2021-10-28 ✅ Patent 12,504,431 granted on 2025-12-23

US20210333281A1

Physics

BIOMARKERS FOR A THERAPY COMPRISING A SORAFENIB COMPOUND

#44 | 2021-09-30 ✅ Patent 12,172,986 granted on 2024-12-24

US20210299269A1

Human necessities

Splicing modulator antibody-drug conjugates and methods of use

#45 | 2021-08-26 ✅ Patent 11,725,015 granted on 2023-08-15

US20210261566A1

Chemistry; metallurgy

Macrocyclic compound and uses thereof

#46 | 2021-08-19 ✅ Patent 12,253,526 granted on 2025-03-18

US20210255191A1

Physics

Fluorescent dye and use thereof

#47 | 2021-08-05 ✅ Patent 11,572,414 granted on 2023-02-07

US20210238304A1

Chemistry; metallurgy

Eribulin antibody-drug conjugates and methods of use

#48 | 2021-07-29 ✅ Patent 11,548,898 granted on 2023-01-10

US20210230177A1

Chemistry; metallurgy

Synthesis of halichondrins

#49 | 2021-07-29 ✅ Patent 12,508,313 granted on 2025-12-30

US20210228722A1

Human necessities

QUINOLINE DERIVATIVE-CONTAINING PHARMACEUTICAL COMPOSITION

#50 | 2021-07-08 ✅ Patent 12,251,394 granted on 2025-03-18

US20210205348A1

Human necessities

Methods for the treatment of bladder cancer

#51 | 2021-07-01 ✅ Patent 11,691,990 granted on 2023-07-04

US20210198282A1

Chemistry; metallurgy

Salts of compounds and crystals thereof

#52 | 2021-06-24 ✅ Patent 11,643,418 granted on 2023-05-09

US20210188867A1

Chemistry; metallurgy

Macrocyclization reactions and intermediates and other fragments useful in the synthesis of analogs of halichondrin B

#53 | 2021-06-17 ✅ Patent 11,679,107 granted on 2023-06-20

US20210177837A1

Human necessities

Certain aryl pladienolide compounds and methods of use

#54 | 2021-06-17

US20210177802A1

Human necessities

PHARMACEUTICAL COMPOSITION FOR TREATING TUMOR

#55 | 2021-06-10 ✅ Patent 11,753,669 granted on 2023-09-12

US20210171998A1

Chemistry; metallurgy

Lysine conjugated immunoglobulins

#56 | 2021-06-10 ✅ Patent 11,136,400 granted on 2021-10-05

US20210171644A1

Chemistry; metallurgy

Anti-EphA4 antibody

#57 | 2021-06-10

US20210171555A1

Chemistry; metallurgy

CHIRAL REAGENTS FOR PREPARATION OF HOMOGENEOUS OLIGOMERS

#58 | 2021-06-03 ✅ Patent 11,926,619 granted on 2024-03-12

US20210163456A1

Chemistry; metallurgy

Certain pladienolide compounds and methods of use

#59 | 2021-05-13 ✅ Patent 11,491,163 granted on 2022-11-08

US20210137936A1

Human necessities

Salt form of a human histone methyltransferase EZH2 inhibitor

#60 | 2021-05-06 ✅ Patent 11,761,045 granted on 2023-09-19

US20210130909A1

Chemistry; metallurgy

Splice variants associated with neomorphic SF3B1 mutants

#61 | 2021-04-22 ✅ Patent 11,083,722 granted on 2021-08-10

US20210113537A1

Human necessities

Combination therapies for the treatment of breast cancer

#62 | 2021-04-15 ✅ Patent 11,312,720 granted on 2022-04-26

US20210107907A1

Chemistry; metallurgy

Hydrochloride salt of 2-((3R,4S)-1-(5-(4-chloro-3,5-difluorophenyl)-7-((2-fluoro-6-methylphenyl)(methyl)amino)pyrazolo[1,5-a]pyrimidine-2-carbonyl)-3-methoxypiperidin-4-yl) acetic acid and crystals thereof

#63 | 2021-04-08 ✅ Patent 11,352,348 granted on 2022-06-07

US20210101888A1

Chemistry; metallurgy

Splicing modulator antibody-drug conjugates and methods of use

#64 | 2021-03-04 ✅ Patent 12,168,014 granted on 2024-12-17

US20210060030A1

Human necessities

Method for treating cancer

#65 | 2021-02-25 ✅ Patent 11,327,078 granted on 2022-05-10

US20210055300A1

Physics

Monoclonal antibody against APOA4, immunological measurement method, and kit for measurement

#66 | 2021-01-28 ✅ Patent 11,578,120 granted on 2023-02-14

US20210024622A1

Chemistry; metallurgy

Anti-Tau antibodies and uses thereof

#67 | 2021-01-28 ✅ Patent 11,420,980 granted on 2022-08-23

US20210024541A1

Chemistry; metallurgy

Salt of pentacyclic compound and crystal thereof

#68 | 2021-01-28 ✅ Patent 11,083,705 granted on 2021-08-10

US20210023047A1

Human necessities

Pharmaceutical composition for treating tumor

#69 | 2021-01-28 ✅ Patent 11,071,713 granted on 2021-07-27

US20210023004A1

Human necessities

Liposome composition

#70 | 2021-01-07 ✅ Patent 10,947,313 granted on 2021-03-16

US20210002378A1

Chemistry; metallurgy

Anti-EphA4 antibody

#71 | 2021-01-07 ✅ Patent 11,660,275 granted on 2023-05-30

US20210000771A1

Human necessities

Epilepsy treatment agent

#72 | 2020-12-31 ✅ Patent 11,186,547 granted on 2021-11-30

US20200407322A1

Chemistry; metallurgy

High-purity quinoline derivative and method for manufacturing same

#73 | 2020-12-03

US20200375975A1

Human necessities

Treatment of Renal Cell Carcinoma with Lenvatinib and Everolimus

#74 | 2020-12-03 ✅ Patent 11,219,619 granted on 2022-01-11

US20200375970A1

Human necessities

Therapeutic agent for hepatocellular carcinoma

#75 | 2020-11-19

US20200361915A1

Chemistry; metallurgy

SOLID STATE FORM OF PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE

#76 | 2020-11-19 ✅ Patent 11,833,119 granted on 2023-12-05

US20200360371A1

Human necessities

Combination therapies for the treatment of hepatocellular carcinoma

#77 | 2020-11-12 ✅ Patent 11,524,009 granted on 2022-12-13

US20200352937A1

Human necessities

Combination comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2 inhibitors, BCL2/BCLxL inhibitors, and BCLxL inhibitors and methods of use

#78 | 2020-11-05 ✅ Patent 11,130,758 granted on 2021-09-28