UCB Biopharma SRL

DIHYDRO-CYCLOPENTA-ISOQUINOLINE SULFONAMIDES DERIVATIVES

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Prodrugs of 2-(3,5-Dichloro-1-methyl-indazol-4-yl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(1-hydroxy-1-methyl-ethyl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]ethanone

#4 | 2024-03-07 ✅ Patent 12,473,355 granted on 2025-11-18

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GREMLIN-1 CRYSTAL STRUCTURE AND INHIBITORY ANTIBODY

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A Substituted Tetrahydroisoquinoline Derivative As A D1 Positive Allosteric Modulator

#6 | 2024-01-04 ✅ Patent 11,975,046 granted on 2024-05-07

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Medical use of interferon-lambda for the treatment of fibrosis

#7 | 2023-12-14 ✅ Patent 12,643,896 granted on 2026-06-02

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DICYCLOPROPYLMETHYL DERIVATIVES AS IL-17 MODULATORS

#8 | 2023-09-28 ✅ Patent 12,577,228 granted on 2026-03-17

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DIHYDROCYCLOPENTA-ISOQUINOLINE-SULFONAMIDE DERIVATIVES COMPOUNDS

#9 | 2023-06-22 ✅ Patent 12,474,348 granted on 2025-11-18

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MODULATOR ASSAY

#10 | 2023-06-08 ✅ Patent 12,240,896 granted on 2025-03-04

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Gremlin-1 inhibitor for the treatment of a bone fracture or bone defect

#11 | 2023-03-23 ✅ Patent 12,570,738 granted on 2026-03-10

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MULTI-SPECIFIC ANTIBODY WITH BINDING SPECIFICITY FOR HUMAN IL-13 AND IL-17

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ANTIBODY WITH BINDING SPECIFICITY FOR HUMAN IL-13

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ANTIBODIES AGAINST KLK5

#14 | 2023-03-09 ✅ Patent 12,338,285 granted on 2025-06-24

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Anti-FcRn Antibodies

#15 | 2023-03-02 ✅ Patent 12,331,117 granted on 2025-06-17

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ANTIBODY MOLECULES WHICH BIND CD22

#16 | 2023-02-16 ✅ Patent 12,410,161 granted on 2025-09-09

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TETRAHYDROBENZO-QUINOLINE SULFONAMIDES DERIVATIVE COMPOUNDS

#17 | 2022-11-10 ✅ Patent 11,710,233 granted on 2023-07-25

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Three-dimensional medical image analysis method and system for identification of vertebral fractures

#18 | 2022-11-03 ✅ Patent 12,275,777 granted on 2025-04-15

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Process for obtaining antibodies

#19 | 2022-10-27 ✅ Patent 12,410,244 granted on 2025-09-09

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ANTI-ALPHA-SYNUCLEIN ANTIBODIES

#20 | 2022-10-20 ✅ Patent 12,018,021 granted on 2024-06-25

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Performing operations; transporting

Thiophene derivatives for the treatment of disorders caused by IgE

#21 | 2022-09-08 ✅ Patent 12,296,285 granted on 2025-05-13

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Methods for purifying antibodies

#22 | 2022-08-18 ✅ Patent 12,643,877 granted on 2026-06-02

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A Substituted Tetrahydroisoquinoiline Derivative as a D1 Positive Allosteric Modulator

#23 | 2022-08-11 ✅ Patent 12,358,890 granted on 2025-07-15

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Performing operations; transporting

A Substituted Tetrahydroisoquinoline Derivative as a D1 Positive Allosteric Modulator

#24 | 2022-08-04 ✅ Patent 12,179,128 granted on 2024-12-31

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HPLC-based detection of flocculation agents in a protein sample

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Anti-IgE antibodies

#26 | 2022-07-21 ✅ Patent 12,391,688 granted on 2025-08-19

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Imidazopyridine Derivatives as IL-17 Modulators

#27 | 2022-07-14 ✅ Patent 12,165,316 granted on 2024-12-10

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Medical image analysis system and method for identification of lesions

#28 | 2022-07-14 ✅ Patent 12,545,720 granted on 2026-02-10

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ANTI-ALPHA-SYNUCLEIN ANTIBODIES

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9H-pyrrolo-dipyridine derivatives

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Methods of use of anti-TNFα antibodies

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Antibodies comprising a polypeptide inserted in framework 3 region

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Treatment of autoimmune disorders with CD154 antibodies

#33 | 2021-10-21 ✅ Patent 11,905,310 granted on 2024-02-20

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Protein purification

#34 | 2021-10-07 ✅ Patent 11,919,950 granted on 2024-03-05

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Expression vector encoding antibody molecule which binds IL-17A and IL-17F

#35 | 2021-08-19 ✅ Patent 12,162,934 granted on 2024-12-10

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Gremlin-1 antagonist for the prevention and treatment of cancer

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METHOD FOR PROTEIN PURIFICATION

#37 | 2021-06-03 ✅ Patent 12,327,614 granted on 2025-06-10

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MULTI-DOMAIN PROTEINS WITH INCREASED NATIVE STATE COLLOIDAL STABILITY

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Gremlin-1 crystal structure and inhibitory antibody

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Fused pentacyclic imidazole derivatives

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Tau-binding antibodies

#41 | 2021-04-22 ✅ Patent 11,732,034 granted on 2023-08-22

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Tau-binding antibodies

#42 | 2021-04-15 ✅ Patent 11,524,997 granted on 2022-12-13

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Gremlin-1 inhibitor for the treatment of a bone fracture or bone defect

#43 | 2021-04-15 ✅ Patent 11,261,242 granted on 2022-03-01

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Anti-alpha-synuclein antibodies

#44 | 2021-04-15 ✅ Patent 11,857,625 granted on 2024-01-02

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Pharmaceutical compositions

#45 | 2021-04-08 ✅ Patent 11,292,831 granted on 2022-04-05

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Anti-alpha synuclein antibodies

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Method of identifying potential inhibitors of APO TNFα trimers

#47 | 2021-03-18 ✅ Patent 11,834,514 granted on 2023-12-05

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Method for increasing the percentage of monomeric antibody Fab-dsFv multimeric species

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Method of monomerisation of recombinant antibody molecules

#49 | 2021-02-25 ✅ Patent 11,472,794 granted on 2022-10-18

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Fused imidazole derivatives as IL-17 modulators

#50 | 2021-01-07 ✅ Patent 11,942,188 granted on 2024-03-26

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Obtaining an improved therapeutic ligand

#51 | 2020-12-31 ✅ Patent 11,518,803 granted on 2022-12-06

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Antagonist antibodies that bind to human TGFB1, TGFB2 and to TGFB3 and their use for the treatment of lung fibrosis

#52 | 2020-12-24 ✅ Patent 11,448,655 granted on 2022-09-20

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Method for identifying a modulator of the TNFα or CD40L interaction with their cognate receptors

#53 | 2020-11-19 ✅ Patent 11,341,639 granted on 2022-05-24

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Three-dimensional medical image analysis method and system for identification of vertebral fractures

#54 | 2020-10-22 ✅ Patent 11,498,941 granted on 2022-11-15

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Chromatography

#55 | 2020-10-01 ✅ Patent 11,859,203 granted on 2024-01-02

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Cell culture methods

#56 | 2020-09-17 ✅ Patent 11,091,542 granted on 2021-08-17

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Antibody molecules which bind TNF alpha

#57 | 2020-09-17 ✅ Patent 11,091,474 granted on 2021-08-17

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Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation

#58 | 2020-09-10 ✅ Patent 11,136,310 granted on 2021-10-05

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Iminotetrahydropyrimidinone derivatives as plasmepsin V inhibitors

#59 | 2020-07-30 ✅ Patent 12,077,796 granted on 2024-09-03

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Cell culture methods

#60 | 2020-05-28 ✅ Patent 12,327,613 granted on 2025-06-10

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DE NOVO ANTIBODY DESIGN

#61 | 2020-05-21 ✅ Patent 11,472,879 granted on 2022-10-18

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Antibody molecules which bind CD22

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Antibodies of the class IGG4

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Spirocyclic indolines as IL-17 modulators

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Process for obtaining antibodies

#65 | 2020-02-20 ✅ Patent 11,401,349 granted on 2022-08-02

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Single linker FabFv antibodies and methods of producing same

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Pharmaceutical composition

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Fused pentacyclic imidazole derivatives as modulators of TNF activity

#68 | 2020-01-23 ✅ Patent 11,261,252 granted on 2022-03-01

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Molecules with specificity for CD79 and CD22

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Fused pentacyclic imidazole derivatives as modulators of TNF activity

#70 | 2019-12-12 ✅ Patent 10,906,966 granted on 2021-02-02

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Tau-binding antibodies

#71 | 2019-12-05 ✅ Patent 10,906,919 granted on 2021-02-02

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Fused pentacyclic imidazole derivatives

#72 | 2019-12-05 ✅ Patent 10,889,584 granted on 2021-01-12

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Bicyclic bis-heteroaryl derivatives as modulators of protein aggregation

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Bis-heteroaryl derivatives as modulators of protein aggregation

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Antibody against trimeric TNFα complex

#75 | 2019-10-31 ✅ Patent 10,947,304 granted on 2021-03-16

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Gremlin-1 antibody

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Antagonist antibodies that bind to human TGFB1, TGFB2 and to TGFB3 and their use for the treatment of lung fibrosis

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Endosomolytic agents for gene therapy

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Methods of treatment using anti-IL-17A/F antibodies

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Substituted benzimidazole derivative as a modulator of TNF activity

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Sequence symmetric modified IgG4 bispecific antibodies

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Method for protein purification

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Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy

#83 | 2019-05-16 ✅ Patent 11,214,627 granted on 2022-01-04

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Anti-IgE antibodies

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Binding domain or antibody specific to a human serum albumin (HSA)

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Dual specificity antibody fusions

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Fused pentacyclic imidazole derivatives as modulators of TNF activity

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Fused pentacyclic imidazole derivatives as modulators of TNF activity

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Fused hexacyclic imidazole derivatives as modulators of TNF activity

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Fused pentacyclic imidazole derivatives as modulators of TNF activity

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Pharmaceutical formulations

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Method employing bispecific protein complex

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Method employing bispecific antibodies

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Multispecific antibodies

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Multispecific antibodies

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Molecular signatures for use in diagnosis and response to treatment analysis of autoimmune diseases

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Recombinant bacterial host cell for protein expression

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Antibody molecules which bind CD45

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Treatment of autoimmune and inflammatory disorders with asymmetric TNF alpha trimers

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Bis-heteroaryl derivatives as modulators of protein aggregation

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