Assignee profile:

Cold Spring Harbor Laboratory

City:

Cold Spring Harbor, New York

Country:

United States

Published Applications:

166

Last publication date:

2025-11-27

Patent Grants:

109

Last grant date:

2025-07-08

Top Inventors for applications by Cold Spring Harbor Laboratory

These are the the leading inventors for applications assigned to Cold Spring Harbor Laboratory:

Recent patent applications by Cold Spring Harbor Laboratory

Cold Spring Harbor Laboratory based in Cold Spring Harbor, US has been assigned the rights to these inventions. The list includes both Pending Applications and Patent Grants:

#1 | 2025-11-27
US20250361556A1
Chemistry; metallurgy

VARIETAL COUNTING OF NUCLEIC ACIDS FOR OBTAINING GENOMIC COPY NUMBER INFORMATION

#2 | 2025-09-18
US20250290128A1
Chemistry; metallurgy

METHOD OF MEASURING MICROSATELLITE LENGTH VARIATIONS

#3 | 2025-08-28
US20250270563A1
Chemistry; metallurgy

TARGETED AUGMENTATION OF NUCLEAR GENE OUTPUT

#4 | 2024-07-18
US20240238326A1
Human necessities

COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING IN A SUBJECT

#5 | 2024-06-20
US20240199561A1
Chemistry; metallurgy

INHIBITORS OF DYRK AND PIM

#6 | 2024-03-28 ✅ Patent 12,351,802 granted on 2025-07-08
US20240102010A1
Chemistry; metallurgy

Novel Structurally Designed shRNAs

#7 | 2023-07-27
US20230235348A1
Chemistry; metallurgy

CONTROL OF MEIOTIC CROSSOVER IN MAIZE

#8 | 2023-02-02
US20230030373A1
Physics

MIXSEQ: MIXTURE SEQUENCING USING COMPRESSED SENSING FOR IN-SITU AND IN-VITRO APPLICATIONS

#9 | 2022-12-29
US20220411809A1
Chemistry; metallurgy

GENE MUTATIONS IN TOMATO TO YIELD COMPACT AND EARLY YIELDING FORMS SUITABLE FOR URBAN AGRICULTURE

#10 | 2022-11-24 ✅ Patent 12,178,825 granted on 2024-12-31
US20220370479A1
Human necessities

Method and compositions for forming a copper-containing complex and uses thereof

#11 | 2022-06-16 ✅ Patent 12,497,411 granted on 2025-12-16
US20220185821A1
Chemistry; metallurgy

MUSCARINIC ACETYLCHOLINE RECEPTOR SUBTYPE 4 ANTAGONISTS IN THE TREATMENT OF ANEMIA

#12 | 2022-02-17 ✅ Patent 12,378,320 granted on 2025-08-05
US20220049011A1
Chemistry; metallurgy

METHODS FOR TREATING PANCREATITIS

#13 | 2022-02-10
US20220042090A1
Chemistry; metallurgy

PROGRAMMABLE RNA-TEMPLATED SEQUENCING BY LIGATION (rSBL)

#14 | 2022-01-06
US20220002740A2
Chemistry; metallurgy

MUTATIONS IN MADS-BOX GENES AND USES THEREOF

#15 | 2021-11-04 ✅ Patent 12,516,367 granted on 2026-01-06
US20210340604A1
Chemistry; metallurgy

RANDOM NUCLEOTIDE MUTATION FOR NUCLEOTIDE TEMPLATE COUNTING AND ASSEMBLY

#16 | 2021-08-26 ✅ Patent 12,215,128 granted on 2025-02-04
US20210261602A1
Chemistry; metallurgy

(Pyridinylmethyl)butanediamine derivatives that chelate copper

#17 | 2021-08-19 ✅ Patent 11,753,641 granted on 2023-09-12
US20210254064A1
Chemistry; metallurgy

Structurally designed shRNAs

#18 | 2021-05-27 ✅ Patent 12,601,734 granted on 2026-04-14
US20210156847A1
Physics

METHODS AND USES OF ENZYMATIC LABELING OF ADP-RIBOSE CONTAINING MOLECULES

#19 | 2020-12-03
US20200376018A1
Human necessities

COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING IN A SUBJECT

#20 | 2020-12-03 ✅ Patent 11,406,647 granted on 2022-08-09
US20200376006A1
Human necessities

Method and compositions for forming a copper-containing complex and uses thereof

#21 | 2020-09-24
US20200299706A1
Chemistry; metallurgy

MUTATIONS IN MADS-BOX GENES AND USES THEREOF

#22 | 2020-09-24 ✅ Patent 12,270,035 granted on 2025-04-08
US20200299705A1
Chemistry; metallurgy

Florigen pathway toolkit

#23 | 2020-09-10 ✅ Patent 11,352,624 granted on 2022-06-07
US20200283762A1
Chemistry; metallurgy

Reducing nonsense-mediated MRNA decay

#24 | 2020-06-25
US20200199604A1
Chemistry; metallurgy

COMPOSITIONS AND METHODS FOR GENERATING WEAK ALLELES IN PLANTS

#25 | 2020-06-11
US20200181613A1
Chemistry; metallurgy

COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING

#26 | 2020-05-21 ✅ Patent 11,643,665 granted on 2023-05-09
US20200157557A1
Chemistry; metallurgy

Nucleotide sequences encoding Fasciated EAR3 (FEA3) and methods of use thereof

#27 | 2020-02-13
US20200048633A1
Chemistry; metallurgy

Novel Structurally Designed shRNAs

#28 | 2020-01-30 ✅ Patent 11,066,668 granted on 2021-07-20
US20200032260A1
Chemistry; metallurgy

Compositions and methods for modulation of IKBKAP splicing

#29 | 2019-12-26 ✅ Patent 12,326,622 granted on 2025-06-10
US20190391415A1
Physics

THERMALLY TUNABLE LOW BROADBAND WAVEGUIDES AND RELATED SYSTEMS AND METHODS

#30 | 2019-12-05 ✅ Patent 11,179,379 granted on 2021-11-23
US20190365734A1
Human necessities

Compositions and methods for hemoglobin production

#31 | 2019-11-28 ✅ Patent 11,739,315 granted on 2023-08-29
US20190360023A1
Chemistry; metallurgy

Genetic copy number determination using high throughput multiplex sequencing of smashed nucleotides

#32 | 2019-11-14 ✅ Patent 11,033,570 granted on 2021-06-15
US20190343863A1
Human necessities

Modulation of Lnc05 expression

#33 | 2019-08-15 ✅ Patent 11,236,330 granted on 2022-02-01
US20190249175A1
Chemistry; metallurgy

Antisense compounds and uses thereof

#34 | 2019-08-15 ✅ Patent 11,660,306 granted on 2023-05-30
US20190247408A1
Human necessities

Treatment of Rett syndrome

#35 | 2019-07-11
US20190211330A1
Chemistry; metallurgy

COMPOSITIONS AND METHODS FOR TREATMENT OF SPINAL MUSCULAR ATROPHY

#36 | 2019-05-23 ✅ Patent 12,234,510 granted on 2025-02-25
US20190153535A1
Chemistry; metallurgy

Varietal counting of nucleic acids for obtaining genomic copy number information

#37 | 2019-03-07 ✅ Patent 12,031,127 granted on 2024-07-09
US20190071666A1
Chemistry; metallurgy

Multiplexed analysis of neuron projections by sequencing

#38 | 2019-01-31
US20190030058A1
Human necessities

COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING IN A SUBJECT

#39 | 2018-12-27 ✅ Patent 10,344,282 granted on 2019-07-09
US20180371457A1
Chemistry; metallurgy

Compositions and methods for modulation of IKBKAP splicing

#40 | 2018-12-27 ✅ Patent 11,083,745 granted on 2021-08-10
US20180369275A1
Human necessities

Antisense oligomers for treatment of autosomal dominant mental retardation-5 and Dravet Syndrome

#41 | 2018-12-20 ✅ Patent 10,696,969 granted on 2020-06-30
US20180362987A1
Chemistry; metallurgy

Targeted augmentation of nuclear gene output

#42 | 2018-10-11
US20180291376A1
Chemistry; metallurgy

COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING

#43 | 2018-09-13 ✅ Patent 10,973,835 granted on 2021-04-13
US20180258106A1
Chemistry; metallurgy

Boron-containing small molecules for inhibiting activity of a receptor-like protein tyrosine phosphatase

#44 | 2018-01-25
US20180023139A1
Chemistry; metallurgy

METHODS OF IDENTIFYING ESSENTIAL PROTEIN DOMAINS

#45 | 2017-11-30 ✅ Patent 10,329,562 granted on 2019-06-25
US20170342410A1
Chemistry; metallurgy

Structurally designed shRNAs

#46 | 2017-10-26 ✅ Patent 11,008,606 granted on 2021-05-18
US20170306392A1
Chemistry; metallurgy

Random nucleotide mutation for nucleotide template counting and assembly

#47 | 2017-09-28 ✅ Patent 10,584,349 granted on 2020-03-10
US20170275642A1
Chemistry; metallurgy

Nucleotide sequences encoding fasciated EAR3 (FEA3) and methods of use thereof

#48 | 2017-07-27 ✅ Patent 10,501,741 granted on 2019-12-10
US20170211072A1
Chemistry; metallurgy

Methods and compositions for inhibiting growth and epithelial to mesenchymal transition (EMT) in cancer cells

#49 | 2017-06-08 ✅ Patent 10,647,983 granted on 2020-05-12
US20170159049A9
Chemistry; metallurgy

Reducing nonsense-mediated mRNA decay

#50 | 2017-06-01 ✅ Patent 10,731,149 granted on 2020-08-04
US20170152548A1
Chemistry; metallurgy

Genetic copy number determination using high throughput multiplex sequencing of smashed nucleotides

#51 | 2017-05-25 ✅ Patent 10,188,640 granted on 2019-01-29
US20170143685A1
Human necessities

Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit

#52 | 2017-05-04
US20170121770A1
Chemistry; metallurgy

TRANSPOSABLE ELEMENTS, TDP-43, AND NEURODEGENERATIVE DISORDERS

#53 | 2017-03-30
US20170088835A1
Chemistry; metallurgy

COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING

#54 | 2017-02-16
US20170044531A1
Chemistry; metallurgy

Transposon Activation During Aging and Neuronal Decline

#55 | 2017-01-19 ✅ Patent 9,717,750 granted on 2017-08-01
US20170015995A1
Chemistry; metallurgy

Compositions and methods for modulation of SMN2 splicing in a subject

#56 | 2016-11-24 ✅ Patent 9,677,139 granted on 2017-06-13
US20160340735A9
Chemistry; metallurgy

Genetic markers indicative of a cancer patient response to trastuzumab (herceptin)

#57 | 2016-10-13 ✅ Patent 9,976,143 granted on 2018-05-22
US20160298121A1
Chemistry; metallurgy

Targeted augmentation of nuclear gene output

#58 | 2016-10-06 ✅ Patent 10,253,326 granted on 2019-04-09
US20160289696A1
Chemistry; metallurgy

Mutant sorghum bicolor having enhanced seed yield

#59 | 2016-09-15 ✅ Patent 10,266,840 granted on 2019-04-23
US20160264986A1
Chemistry; metallurgy

Sorghum yield enhancement gene

#60 | 2016-09-01 ✅ Patent 10,947,589 granted on 2021-03-16
US20160251715A1
Chemistry; metallurgy

Varietal counting of nucleic acids for obtaining genomic copy number information

#61 | 2016-07-14 ✅ Patent 9,957,514 granted on 2018-05-01
US20160201069A1
Chemistry; metallurgy

Transformation of duckweed and uses thereof

#62 | 2016-07-07 ✅ Patent 9,845,467 granted on 2017-12-19
US20160194637A1
Chemistry; metallurgy

Compounds and methods for modulating target nuclear and sub-nuclear nucleic acid molecules in cells and animals

#63 | 2016-07-07
US20160194630A1
Chemistry; metallurgy

REDUCING NONSENSE-MEDIATED MRNA DECAY

#64 | 2015-12-10
US20150353929A1
Chemistry; metallurgy

COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING

#65 | 2015-10-08 ✅ Patent 11,624,074 granted on 2023-04-11
US20150284732A1
Chemistry; metallurgy

Mutations in solanaceae plants that modulate shoot architecture and enhance yield-related phenotypes

#66 | 2015-10-01
US20150275211A1
Chemistry; metallurgy

ANTISENSE COMPOUNDS AND USES THEREOF

#67 | 2015-07-16 ✅ Patent 9,624,494 granted on 2017-04-18
US20150197749A1
Chemistry; metallurgy

Structurally designed shRNAs

#68 | 2015-02-12 ✅ Patent 9,701,979 granted on 2017-07-11
US20150047071A1
Chemistry; metallurgy

Nucleotide sequences encoding fasciated EAR3 (FEA3) and methods of use thereof

#69 | 2015-01-29 ✅ Patent 9,850,495 granted on 2017-12-26
US20150033415A1
Chemistry; metallurgy

Nucleotide sequences encoding fasciated EAR4 (FEA4) and methods of use thereof

#70 | 2014-12-25 ✅ Patent 9,422,605 granted on 2016-08-23
US20140377758A1
Chemistry; metallurgy

Transposon activation during aging and neuronal decline

#71 | 2014-12-04
US20140357558A1
Chemistry; metallurgy

COMPOSITIONS AND METHODS FOR TREATMENT OF SPINAL MUSCULAR ATROPHY

#72 | 2014-10-02
US20140298496A1
Human necessities

PHENOCOPY MODEL OF DISEASE

#73 | 2014-10-02
US20140297199A1
Physics

DRUG SCREENING METHOD AND USES THEREOF

#74 | 2014-09-18
US20140283156A1
Chemistry; metallurgy

TRANS-SPLICING RIBOZYMES AND SILENT RECOMBINASES

#75 | 2014-09-18 ✅ Patent 9,752,179 granted on 2017-09-05
US20140272988A1
Chemistry; metallurgy

Trans-splicing transcriptome profiling

#76 | 2014-07-17 ✅ Patent 9,382,227 granted on 2016-07-05
US20140200244A1
Chemistry; metallurgy

Phenylethanolamine-based NMDA receptor antagonists

#77 | 2014-05-22 ✅ Patent 9,732,352 granted on 2017-08-15
US20140143898A1
Human necessities

Mutations in Solanaceae plants that modulate shoot architecture and enhance yield-related phenotypes

#78 | 2014-04-24 ✅ Patent 9,441,223 granted on 2016-09-13
US20140113952A1
Chemistry; metallurgy

Transposable elements, TDP-43, and neurodegenerative disorders

#79 | 2014-03-06 ✅ Patent 9,404,156 granted on 2016-08-02
US20140065609A1
Chemistry; metallurgy

Varietal counting of nucleic acids for obtaining genomic copy number information

#80 | 2014-01-23
US20140025307A1
Physics

DETERMINING A PROBABILISTIC DIAGNOSIS OF CANCER BY ANALYSIS OF GENOMIC COPY NUMBER VARIATIONS

#81 | 2014-01-09 ✅ Patent 9,815,849 granted on 2017-11-14
US20140011862A1
Chemistry; metallurgy

Compositions and methods for treating leukemia

#82 | 2013-11-14 ✅ Patent 9,271,987 granted on 2016-03-01
US20130302337A1
Human necessities

Methods and compositions for treating Alzheimer's disease

#83 | 2013-10-31 ✅ Patent 9,518,259 granted on 2016-12-13
US20130289092A1
Chemistry; metallurgy

Compounds and methods for modulating interaction between proteins and target nucleic acids

#84 | 2013-10-17 ✅ Patent 8,829,264 granted on 2014-09-09
US20130276158A1
Chemistry; metallurgy

Methods and compositions for RNA interference

#85 | 2013-08-22 ✅ Patent 9,150,876 granted on 2015-10-06
US20130219553A1
Chemistry; metallurgy

Nucleotide sequences encoding RAMOSA3 and sister of RAMOSA3 and methods of use for same

#86 | 2013-07-11 ✅ Patent 8,993,532 granted on 2015-03-31
US20130179999A1
Chemistry; metallurgy

Structurally designed shRNAs

#87 | 2013-06-27
US20130164721A1
Physics

AUGMENTED COGNITIVE TRAINING

#88 | 2013-04-18
US20130097718A1
Chemistry; metallurgy

CHD5 IS A NOVEL TUMOR SUPPRESSOR GENE

#89 | 2013-03-21
US20130074200A2
Chemistry; metallurgy

INBRED C57BL/6 ES CELLS WITH HIGH DEVELOPMENTAL CAPACITY

#90 | 2013-01-31 ✅ Patent 9,074,002 granted on 2015-07-07
US20130029366A9
Chemistry; metallurgy

PTP1B inhibitors

#91 | 2012-12-06
US20120309017A1
Physics

PERINUCLEOLAR COMPARTMENT AS A CANCER MARKER

#92 | 2012-12-04 ✅ Patent 8,323,883 granted on 2012-12-04
US12903133
-

Methods of assessing therapeutic benefits of patients having cancers resistant to epidermal growth factor receptor kinase inhibitors

#93 | 2012-11-22 ✅ Patent 8,648,198 granted on 2014-02-11
US20120294804A1
Chemistry; metallurgy

Phenylethanolamine-based NMDA receptor antagonists

#94 | 2012-10-25 ✅ Patent 8,895,526 granted on 2014-11-25
US20120272346A1
Human necessities

Identification of RNAI targets and use of RNAI for rational therapy of chemotherapy-resistant leukemia and other cancers

#95 | 2012-07-26
US20120192299A1
Chemistry; metallurgy

INBRED C57BL/6 ES CELLS WITH HIGH DEVELOPMENTAL CAPACITY

#96 | 2012-07-26 ✅ Patent 8,980,853 granted on 2015-03-17
US20120190728A1
Human necessities

Compositions and methods for modulation of SMN2 splicing in a subject

#97 | 2012-06-28
US20120164673A1
Chemistry; metallurgy

PTP1B INHIBITORS

#98 | 2012-06-14 ✅ Patent 8,753,811 granted on 2014-06-17
US20120149602A1
Chemistry; metallurgy

Method for making populations of defined nucleic acid molecules

#99 | 2012-04-05 ✅ Patent 8,426,675 granted on 2013-04-23
US20120084872A1
Human necessities

Methods for producing microRNAs

#100 | 2012-03-13 ✅ Patent 8,133,670 granted on 2012-03-13
US10860559
-

Method for making populations of defined nucleic acid molecules

AssigneeID:

7222 ⎘