Institut Pasteur

Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins

#2 | 2026-04-23

US20260108591A1

Malaria pre-erythrocytic antigens as a fusion polypeptide and their use in the elicitation of a protective immune response in a host

#3 | 2025-10-09

US20250312385A1

LACHNOSPIRACEAE SPP AND RUMINOCOCCUS LACTARIS STRAINS FOR THE TREATMENT AND PREVENTION OF ALZHEIMER'S DISEASE AND AGING

#4 | 2025-09-25

US20250295716A1

DUAL RECOMBINANT AAV8 VECTOR SYSTEM ENCODING ISOFORM 5 OF OTOFERLIN AND USES THEREOF

#5 | 2025-04-22 ✅ Patent 12,281,155 granted on 2025-04-22

US18417613

Broadly SARS-CoV-2 neutralizing monoclonal antibodies and uses thereof

#6 | 2025-02-20 ✅ Patent 12,324,834 granted on 2025-06-10

US20250057942A1

NUCLEIC ACID VACCINE AGAINST THE SARS-COV-2 CORONAVIRUS

#7 | 2025-02-06 ✅ Patent 12,613,239 granted on 2026-04-28

US20250044282A1

LIVE IMAGING SYSTEM TO VISUALIZE THE RETRO-TRANSCRIBED VIRAL DNA GENOME

#8 | 2025-01-23

US20250025541A1

IMMUNOGENIC PRODUCT COMPRISING IL-4 AND/OR IL-13 FOR TREATING DISORDERS ASSOCIATED WITH ABERRANT IL-4 AND/OR IL 13 EXPRESSION OR ACTIVITY

#9 | 2025-01-09

US20250014299A1

METHOD FOR VISUALIZING AT LEAST A ZONE OF AN OBJECT IN AT LEAST ONE INTERFACE

#10 | 2024-11-14 ✅ Patent 12,505,543 granted on 2025-12-23

US20240378720A1

METHOD FOR IDENTIFYING ABNORMALITIES IN CELLS OF INTEREST IN A BIOLOGICAL SAMPLE

#11 | 2024-11-07

US20240368713A1

ANELLOVIRUS GENOME QUANTIFICATION AS A BIOMARKER OF IMMUNE SUPPRESSION

#12 | 2024-10-17 ✅ Patent 12,478,652 granted on 2025-11-25

US20240342230A1

BACTERIOPHAGE THERAPY

#13 | 2024-08-15 ✅ Patent 12,448,412 granted on 2025-10-21

US20240270790A1

ANTIGENIC TRIPEPTIDES DERIVED FROM MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS S-TYPE STRAINS, DERIVATIVES AND USES THEREOF

#14 | 2024-08-01 ✅ Patent 12,286,652 granted on 2025-04-29

US20240254459A1

Variants of terminal deoxynucleotidyl transferase and uses thereof

#15 | 2024-08-01 ✅ Patent 12,171,827 granted on 2024-12-24

US20240252622A1

Nucleic acid vaccine against the SARS-CoV-2 coronavirus

#16 | 2024-06-20 ✅ Patent 12,576,164 granted on 2026-03-17

US20240197923A1

IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS

#17 | 2024-03-28

US20240100048A1

DIPEPTIDYLPEPTIDASE 4 INHIBITION ENHANCES LYMPHOCYTE TRAFFICKING, IMPROVING BOTH NATURALLY OCCURRING TUMOR IMMUNITY AND IMMUNOTHERAPY

#18 | 2024-02-08 ✅ Patent 11,969,467 granted on 2024-04-30

US20240042014A1

Nucleic acid vaccine against the SARS-CoV-2 coronavirus

#19 | 2024-01-25 ✅ Patent 11,964,013 granted on 2024-04-23

US20240024462A1

Nucleic acid vaccine against the SARS-CoV-2 coronavirus

#20 | 2024-01-04 ✅ Patent 12,606,587 granted on 2026-04-21

US20240002423A1

PROTECTED TETRASACCHARIDES, THEIR PROCESS OF PREPARATION AND THEIR USE AS TRANSGLUCOSYLASE ACCEPTOR SUBSTRATES IN THE CHEMO-ENZYMATIC SYNTHESIS OF SHIGELLA FLEXNERI SPECIFIC OLIGOSACCHARIDES

#21 | 2024-01-04 ✅ Patent 11,911,462 granted on 2024-02-27

US20240000922A1

Nucleic acid vaccine against the SARS-CoV-2 coronavirus

#22 | 2023-11-16

US20230364232A1

IMMUNOGENIC PRODUCT COMPRISING AN IgE FRAGMENT FOR TREATING IgE-MEDIATED INFLAMMATORY DISORDERS

#23 | 2023-07-27 ✅ Patent 12,620,100 granted on 2026-05-05

US20230237664A1

METHOD FOR DETECTING SPATIAL COUPLING

#24 | 2023-07-27 ✅ Patent 12,283,045 granted on 2025-04-22

US20230237651A1

Multi-channel extended depth-of-field method for automated digital cytology

#25 | 2023-07-13 ✅ Patent 12,136,181 granted on 2024-11-05

US20230222748A1

Method for visualizing at least a zone of an object in at least one interface

#26 | 2023-05-18 ✅ Patent 12,529,114 granted on 2026-01-20

US20230151439A1

A NOVEL ORTHOBUNYAVIRUS IN HUMAN ENCEPHALITIS AND ITS DIAGNOSTIC AND THERAPEUTIC APPLICATONS

#27 | 2023-04-27 ✅ Patent 12,516,302 granted on 2026-01-06

US20230130605A1

DNA POLYMERASE THETA MUTANTS, METHODS OF PRODUCING THESE MUTANTS, AND THEIR USES

#28 | 2023-02-16 ✅ Patent 11,981,750 granted on 2024-05-14

US20230046953A1

Antigenic tripeptides derived from subsp. s-type strains, derivatives and uses thereof

#29 | 2022-12-22 ✅ Patent 11,759,516 granted on 2023-09-19

US20220401550A1

Nucleic acid vaccine against the SARS-CoV-2 coronavirus

#30 | 2022-11-03 ✅ Patent 12,214,022 granted on 2025-02-04

US20220347271A1

Sequence-specific antimicrobials by blocking DNA repair

#31 | 2022-10-06 ✅ Patent 12,105,095 granted on 2024-10-01

US20220317131A1

Assay to detect and quantitate specific antibodies for various redox forms of HMGB1

#32 | 2022-07-28 ✅ Patent 11,872,276 granted on 2024-01-16

US20220233678A1

Zika virus chimeric polyepitope comprising non-structural proteins and its use in an immunogenic composition

#33 | 2022-07-28

US20220233503A1

METHODS OF TREATING SEPSIS WITH SYNAPTIC VESICLE 2A AND/OR 2B BINDING CHEMICAL ENTITIES

#34 | 2022-07-21

US20220226307A1

INHIBITION OF BETA-2 NICOTINIC ACETYLCHOLINE RECEPTORS TO TREAT ALZHEIMER'S DISEASE PATHOLOGY

#35 | 2022-06-23 ✅ Patent 12,473,581 granted on 2025-11-18

US20220195486A1

Multiplexable microfluidic culture chamber for imaging monolayer growth of single cells

#36 | 2022-06-23 ✅ Patent 12,611,445 granted on 2026-04-28

US20220193198A1

Interleukin-2 Variants with Modified Biological Activity

#37 | 2022-04-28

US20220128572A1

IMMUNOLOGICAL SIGNATURES AND PARAMETERS PREDICTING THERAPEUTIC RESPONSES TO ANTI-TNF THERAPY

#38 | 2022-04-21

US20220119886A1

MEANS FOR DIAGNOSING, PREDICTING OR MONITORING PNEUMOCYSTIS PNEUMONIA

#39 | 2022-04-21 ✅ Patent 11,883,398 granted on 2024-01-30

US20220117960A1

Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy

#40 | 2022-02-10 ✅ Patent 11,815,513 granted on 2023-11-14

US20220042987A1

Severe acute respiratory syndrome (SARS)-associated coronavirus diagnostics

#41 | 2022-01-27 ✅ Patent 11,884,708 granted on 2024-01-30

US20220025002A1

Stapled peptide inhibitors of nemo as potential anti-inflammatory and anti-cancer drugs

#42 | 2021-12-23 ✅ Patent 11,642,404 granted on 2023-05-09

US20210393760A1

Plasmodium with histamine releasing factor (HRF) deficiency for use as a vaccine

#43 | 2021-12-16 ✅ Patent 11,918,613 granted on 2024-03-05

US20210386805A1

Bacteriophage therapy

#44 | 2021-12-09 ✅ Patent 11,946,056 granted on 2024-04-02

US20210380993A1

Optimized vector for delivery in microbial populations

#45 | 2021-11-18 ✅ Patent 11,926,648 granted on 2024-03-12

US20210355167A1

Neutralising antibody against dengue for use in a method of prevention and/or treatment of Zika infection

#46 | 2021-10-07 ✅ Patent 12,326,451 granted on 2025-06-10

US20210311054A1

SEVERE ACUTE RESPIRATORY SYNDROME (SARS) - ASSOCIATED CORONAVIRUS DIAGNOSTICS

#47 | 2021-09-09 ✅ Patent 11,795,515 granted on 2023-10-24

US20210277489A1

Methods and reagents for the specific and sensitive detection of SARS-CoV-2

#48 | 2021-08-19 ✅ Patent 12,533,404 granted on 2026-01-27

US20210252131A1

COMPOSITIONS AND METHODS COMPRISING MEASLES VIRUS DEFECTIVE INTERFERING PARTICLES FOR THE PREVENTION OF INFECTIOUS DISEASES

#49 | 2021-07-15 ✅ Patent 12,065,461 granted on 2024-08-20

US20210214382A1

Method for preparing 3′-O-amino-2′-deoxyribonucleoside-5′-triphosphate

#50 | 2021-07-08 ✅ Patent 11,638,751 granted on 2023-05-02

US20210205436A1

Immunogenic composition comprising a recombinant attenuated mopeia virus with a modified nucleoprotein displaying reduced exonuclease activity

#51 | 2021-07-08 ✅ Patent 12,059,457 granted on 2024-08-13

US20210205427A1

Immunogenic product comprising IL-4 and/or IL-13 for treating disorders associated with aberrant IL-4 and/or IL 13 expression or activity

#52 | 2021-07-01 ✅ Patent 11,732,312 granted on 2023-08-22

US20210198755A1

Molecular marker of plasmodium falciparum artemisinin resistance

#53 | 2021-06-24 ✅ Patent 12,567,481 granted on 2026-03-03

US20210193259A1

METHOD, DEVICE, AND COMPUTER PROGRAM FOR GENERATING PROTEIN SEQUENCES WITH AUTOREGRESSIVE NEURAL NETWORKS

#54 | 2021-06-24 ✅ Patent 12,521,428 granted on 2026-01-13

US20210187089A1

Malaria pre-erythrocytic antigens as a fusion polypeptide and their use in the elicitation of a protective immune response in a host

#55 | 2021-04-15 ✅ Patent 11,680,245 granted on 2023-06-20

US20210108177A1

Human innate lymphoid cell precursors: identification, characterization, applications

#56 | 2021-04-01 ✅ Patent 12,163,150 granted on 2024-12-10

US20210095315A1

Recombinant measles viruses expressing epitopes of antigens of RNA viruses—use for the preparation of vaccine compositions

#57 | 2021-04-01 ✅ Patent 11,618,781 granted on 2023-04-04

US20210095009A1

Polyclonal antibodies specific for serogroup X of N. meningitidis and uses thereof in diagnosis

#58 | 2021-03-18 ✅ Patent 11,351,246 granted on 2022-06-07

US20210077613A1

Recombinant measles vaccine expressing hTERT

#59 | 2021-02-11 ✅ Patent 11,339,211 granted on 2022-05-24

US20210040187A1

Nanobodies suitable for neuron regeneration therapy

#60 | 2021-02-04 ✅ Patent 11,530,452 granted on 2022-12-20

US20210032705A1

Broad range gene and genotype papillomavirus transcriptome as a biomarker of papillomavirus-associated cancer stages

#61 | 2021-01-14

US20210010094A1

TREATMENTS TO ELIMINATE HIV RESERVOIRS AND REDUCE VIRAL LOAD

#62 | 2021-01-14 ✅ Patent 11,208,637 granted on 2021-12-28

US20210009970A1

Variants of terminal deoxynucleotidyl transferase and uses thereof

#63 | 2021-01-07 ✅ Patent 11,723,968 granted on 2023-08-15

US20210000940A1

Stabilized recombinant hantaviral spike proteins comprising mutations in Gc

#64 | 2020-12-24 ✅ Patent 11,078,490 granted on 2021-08-03

US20200399645A1

Optimized vector for delivery in microbial populations

#65 | 2020-12-10 ✅ Patent 11,643,625 granted on 2023-05-09

US20200385659A1

Hydrogel-based organ-on-chip microfluidic device

#66 | 2020-11-26 ✅ Patent 11,472,844 granted on 2022-10-18

US20200369729A1

Peptidomimetics, method of synthesis and uses thereof

#67 | 2020-11-12 ✅ Patent 11,723,977 granted on 2023-08-15

US20200354436A1

Broadly neutralizing antibodies directed against the rabies virus glycoprotein and uses thereof

#68 | 2020-11-12 ✅ Patent 11,730,813 granted on 2023-08-22

US20200354435A1

Broadly neutralizing antibodies directed against the rabies virus glycoprotein and uses thereof

#69 | 2020-11-12 ✅ Patent 11,679,140 granted on 2023-06-20

US20200353039A1

Prevention and/or treatment of hearing loss or impairment

#70 | 2020-10-29 ✅ Patent 12,250,944 granted on 2025-03-18

US20200337299A1

High-fidelity long-term storage of biological material

#71 | 2020-10-01 ✅ Patent 11,976,305 granted on 2024-05-07

US20200308555A1

Lassa vaccine

#72 | 2020-09-10 ✅ Patent 11,305,003 granted on 2022-04-19

US20200282043A1

Zika virus chimeric polyepitope comprising non-structural proteins and its use in an immunogenic composition

#73 | 2020-08-27 ✅ Patent 11,229,645 granted on 2022-01-25

US20200268859A1

Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy

#74 | 2020-08-20 ✅ Patent 12,188,057 granted on 2025-01-07

US20200263151A1

Primer-independent DNA polymerases and their use for DNA synthesis

#75 | 2020-08-06 ✅ Patent 11,676,247 granted on 2023-06-13

US20200250794A1

Method, device, and computer program for improving the reconstruction of dense super-resolution images from diffraction-limited images acquired by single molecule localization microscopy

#76 | 2020-08-06 ✅ Patent 11,905,516 granted on 2024-02-20

US20200248192A1

Optimized vector for delivery in microbial populations

#77 | 2020-07-30 ✅ Patent 11,857,616 granted on 2024-01-02

US20200237893A1

Recombinant measles virus expressing zika virus prM and E proteins

#78 | 2020-07-23 ✅ Patent 11,779,640 granted on 2023-10-10

US20200230228A1

Lentiviral vector-based Japanese encephalitis immunogenic composition

#79 | 2020-07-16 ✅ Patent 11,384,345 granted on 2022-07-12

US20200224181A1

DNA polymerase theta mutants, methods of producing these mutants, and their uses

#80 | 2020-06-11 ✅ Patent 11,434,585 granted on 2022-09-06

US20200181601A1

OB-fold used as scaffold for engineering new specific binders

#81 | 2020-05-28 ✅ Patent 11,124,563 granted on 2021-09-21

US20200165329A1

Camelid single-domain antibody directed against phosphorylated tau proteins and methods for producing conjugates thereof

#82 | 2020-05-28 ✅ Patent 11,834,468 granted on 2023-12-05

US20200165285A1

Protected tetrasaccharides, their process of preparation and their use as transglucosylase acceptor substrates in the chemo-enzymatic synthesis of specific oligosaccharides

#83 | 2020-05-21 ✅ Patent 11,504,049 granted on 2022-11-22

US20200155055A1

Olfactory means useful in the diagnosis and treatment of mood depression

#84 | 2020-04-30 ✅ Patent 11,938,199 granted on 2024-03-26

US20200129644A1

Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins

#85 | 2020-04-23 ✅ Patent 11,369,670 granted on 2022-06-28

US20200121776A1

Multiple malaria pre-erythrocytic antigens and their use in the elicitation of a protective immune response in a host

#86 | 2020-04-23 ✅ Patent 11,357,831 granted on 2022-06-14

US20200121768A1

Sequence-specific antimicrobials by blocking DNA repair

#87 | 2020-04-23 ✅ Patent 11,317,848 granted on 2022-05-03

US20200121239A1

Olfactory means for the diagnosis of neurological complications of nervous system infection

#88 | 2020-03-26 ✅ Patent 10,793,877 granted on 2020-10-06

US20200095607A1

Recombinant measles viruses expressing epitopes of antigens of RNA viruses—use for the preparation of vaccine compositions

#89 | 2020-02-27 ✅ Patent 11,344,515 granted on 2022-05-31

US20200060999A1

5-hydroxytryptamine 1B receptor-stimulating agent for use as a promoter of satellite cells self-renewal and/or differentiation

#90 | 2020-02-13 ✅ Patent 11,287,433 granted on 2022-03-29

US20200049718A1

Methods for in vitro investigating mitochondrial replication dysfunction in a biological sample, kits and uses thereof, therapeutic methods against progeroid-like syndromes or symptoms and screening method for identifying particular protease inhibitor(s) and/or nitroso-redox stress scavenger compound(s)

#91 | 2020-02-06 ✅ Patent 10,808,254 granted on 2020-10-20

US20200040346A1

Optimized vector for delivery in microbial populations

#92 | 2020-01-23 ✅ Patent 11,498,942 granted on 2022-11-15

US20200024307A1

Antigenic tripeptides derived from subsp. s-type strains, derivatives and uses thereof

#93 | 2020-01-16 ✅ Patent 10,980,873 granted on 2021-04-20

US20200016260A1

Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-deltaC virus) in cancer therapy

#94 | 2019-12-26 ✅ Patent 10,752,887 granted on 2020-08-25

US20190390178A1

Variants of terminal deoxynucleotidyl transferase and uses thereof

#95 | 2019-12-19 ✅ Patent 11,149,070 granted on 2021-10-19

US20190382456A1

Stapled peptide inhibitors of NEMO as potential anti-inflammatory and anti-cancer drugs

#96 | 2019-12-05 ✅ Patent 11,725,183 granted on 2023-08-15

US20190367867A1

Method of culturing segmented filamentous bacteria in vitro

#97 | 2019-10-31 ✅ Patent 11,566,280 granted on 2023-01-31

US20190330691A1

Method, probe and kit for DNA in situ hybridization and use thereof

#98 | 2019-10-03 ✅ Patent 11,034,730 granted on 2021-06-15

US20190300578A1

Dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection

#99 | 2019-08-22 ✅ Patent 11,111,274 granted on 2021-09-07

US20190256560A1

Neutralising antibody against dengue for use in a method of prevention and/or treatment of zika infection

#100 | 2019-07-18 ✅ Patent 10,815,540 granted on 2020-10-27

US20190218628A1