20612 ⎘
Medicinal preparations containing materials or reaction products thereof with undetermined constitution; Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells Tumour cells, irrespective of tissue of origin
Differential Knockout of An Allele of A Heterozygous Apolipoprotein A1 (APO1A) Gene
#2METHODS AND USE FOR BIOENGINEERING ENUCLEATED CELLS
#3SYSTEMS AND METHODS FOR COORDINATING MANUFACTURING OF CELLS FOR PATIENT-SPECIFIC IMMUNOTHERAPY
#4NEOANTIGEN IMMUNOTHERAPY
#5CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF
#6BIODIFFUSION CHAMBER
#7NANO-ENGINEERED THERAPEUTIC STEALTH CELLS
#8CRIPTO-POSITIVE LIPID VESICLES FOR USE IN THE THERAPEUTIC TREATMENT OF AGGRESSIVE TUMOURS
#9MODIFIED EXOSOMES AND METHODS OF USE
#10Cerebrovascular-Tumor-On-A-Chip
#11COMPOSITION FOR ANTI-CANCER TREATMENT COMPRISING IMMUNOGENIC TUMOR-DERIVED EXTRACELLULAR VESICLES USING AN ENDOPLASMIC RETICULUM STRESS INDUCER AND METHOD FOR PRODUCING THE SAME
#12SILICIFIED IMMUNOGENIC CELLS, METHODS OF MAKING, AND METHODS OF USING
#13Compositions and Methods for Treating Cancer
#14METHODS AND COMPOSITIONS FOR NATURAL KILLER CELLS
#15Pharmaceutical Composition and Method for Treating Neurodegenerative Disorders Utilising the Pharmaceutical Composition
#16CELL-DERIVED VESICLE RICH IN PROTEIN HOMEOSTASIS REGULATORS AND METHOD OF PREPARING SAME
#17FRAGMENT SIZE CHARACTERIZATION OF CELL-FREE DNA MUTATIONS FROM CLONAL HEMATOPOIESIS
#18ENHANCED CELL-DERIVED VESICLES FOR CANCER THERAPY
#19COMBINATION THERAPIES USING IMMUNO-DASH INHIBITORS AND PGE2 ANTAGONISTS
#20TROJAN CIRCULATING TUMOR CELLS
#21Compositions comprising bacteria for cancer immunotherapy
#22CELL SHEET FOR GENE DELIVERY
#23DASH INHIBITORS, AND USES RELATED THERETO
#24METHOD OF TREATING DIFFICULT TO ACCESS TUMORS WITH PHOTOACTIVATED CANCER THERAPY
#25METHODS OF TREATING CANCER USING A COMBINATION OF TUMOR MEMBRANE VESICLES AND METFORMIN
#26NANOPARTICLE-LOADED SILICIFIED CELLS, METHODS OF MAKING, AND METHODS OF USE
#27METHODS OF GENERATING AND USING SENESCENT-INDUCED CELLS FOR TREATMENT OF CANCER AND COMPOSITIONS RELATING THERETO
#28INDUCTION OF HIGHLY EFFICACIOUS ANTI-TUMOR AND IMMUNE MODULATING ACTIVITY: CELL-FREE OFF THE SHELF THERAPEUTIC MODALITY
#29IMMUNOMODULATING TUMOR NECROSIS FACTOR RECEPTOR 25 (TNFR25) AGONISTS, ANTAGONISTS, AND IMMUNOTOXINS
#30CELL-BASED VEHICLES FOR POTENTIATION OF VIRAL THERAPY
#31METHODS AND USE FOR BIOENGINEERING ENUCLEATED CELLS
#32COMBINATORIAL CANCER IMMUNOTHERAPY
#33METHODS OF TREATING BRAF-MUTATED CANCER CELLS
#34ANTI-CD47 MONOCLONAL ANTIBODY AND USE THEREOF
#35FIBROBLAST GENERATED PATIENT-SPECIFIC VACCINES
#36Tumor cell vaccines
#37C3D CELLULAR AND ACELLULAR VACCINES FOR THE PREVENTION AND TREATMENT OF CANCER
#38METHOD FOR COLD ATMOSPHERIC PLASMA EXOSOME THERAPY
#39Method of treating, reducing, or alleviating a medical condition in a patient
#40Methods and compositions for natural killer cells
#41CELL TREATMENTS AND THERAPEUTIC REINFUSION METHODS
#42Culture Medium
#43BAFF THERAPY TO PROMOTE ANTI-TUMOR IMMUNITY
#44Silicified immunogenic cells, methods of making, and methods of using
#45Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
#46Isolation of Different Extracellular Vesicle (EV) Subpopulations
#47WHOLE CELL TUMOR VACCINES AND METHODS OF USE THEROF
#48Method for Producing an Exosome Containing Agent for Metastasis Suppression
#49TREATMENT OF NSCLC PATIENTS REFRACTORY FOR ANTI-PD-1 ANTIBODY
#50Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
#51Combination therapies using immuno-dash inhibitors and PGE2 antagonists
#52COMPOSITIONS AND METHODS RELATED TO TUMOR CELL KILLERS AND VACCINES
#53SUBSTANCE FOR TREATING AND/OR PREVENTING TUMORS, AND DESIGN METHOD AND PREPARATION METHOD THEREOF
#54METHODS AND COMPOSITIONS FOR TREATING BREAST CANCER USING ANTISENSE
#55Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
#56Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
#57METHODS AND COMPOSITIONS FOR TREATING HEPATOCELLULAR CARCINOMA USING ANTISENSE
#58Method for preparing cell extract component or composition having cytocidal activity
#59Nano-engineered therapeutic stealth cells
#60METHOD FOR PREPARING CANCER STEM CELL SPHEROIDS
#61Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
#62Vaccines and vaccine components for inhibition of microbial cells
#63DOUBLE-CROSSLINKED SELF-HEALING HYDROGEL
#64Blood-brain barrier comprising engineered endothelial cells
#65METHOD AND COMPOSITION FOR AMELIORATING AND ABATING SYMPTOMS RESULTING FROM RHEUMATOID ARTHRITIS, FIBROMYALGIA, AND CHRONIC PAIN OF UNKNOWN ORIGIN
#66Use of apoptotic compensatory proliferation signaling vesicles in tissue repair and wound healing
#67INDUCTION OF ANTI-TUMORAL IMMUNE MICROENVIRONMENTS
#68Methods for treating cancers
#69Chemically and photochemically initiated cell membrane blebbing to induce cell vesicle production, modifications thereof, and uses thereof
#70Cytotoxic immunostimulating particles and uses thereof
#71DNA damage response signature guided rational design of CRISPR-based systems and therapies
#72Fragment size characterization of cell-free DNA mutations from clonal hematopoiesis
#73CELL SHEET FOR GENE DELIVERY
#74BIODIFFUSION CHAMBER
#75Suppressive Exosomes in Cancer and for Immunosuppression
#76Method for Producing an Exosome Containing Agent for Metastasis Suppression
#77DIFFERENTIAL KNOCKOUT OF AN ALLELE OF A HETEROZYGOUS APOLIPOPROTEIN A1 (APO1A) GENE
#78METHOD FOR IMMUNOTHERAPY DRUG TREATMENT
#79EXTRACELLULAR MATRIX COMPOSITIONS FOR THE TREATMENT OF CANCER
#80Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins
#81Method for tissue regeneration using cancer cell-derived exosomes
#82Vaccines and vaccine components for inhibition of microbial cells
#83Cell-based vehicles for potentiation of viral therapy
#84Methods and devices for stimulating an immune response using nanosecond pulsed electric fields
#85Reoviruses having modified sequences
#86ISOLATION OF EXTRACELLULAR VESICLES (EVS) FROM RED BLOOD CELLS FOR GENE THERAPY
#87Method for preparing cell extract component or composition having cytocidal activity
#88EXTRACELLULAR VESICLES FOR AGENT DELIVERY
#89Autologous irradiated whole cell tumor vaccines lentivirally engineered to express CD80, IL-15 and IL-15 receptor alpha
#90Method for inducing production of vascular endothelial growth factor
#91CRYOPRESERVATION OF APOPTOTIC CANCER CELLS FOR USE IN IMMUNOTHERAPY AGAINST CANCER
#92IN VIVO PRIMING OF NATURAL KILLER CELLS
#93CANCER STEM CELL EXOSOMES
#94EXOSOME-BASED NANOPARTICLE COMPOSITE AND METHOD FOR PREPARING THE SAME
#95Combination therapies using immuno-dash inhibitors and PGE2 antagonists
#96Cell-based vehicles for potentiation of viral therapy
#97NOVEL MINOR HISTOCOMPATIBILITY ANTIGENS AND USES THEREOF
#98Methods and devices for stimulating an immune response using nanosecond pulsed electric fields
#99Complexes of IL-15 and IL-15Ralpha and uses thereof
#100Generation of Tumor Endothelium Specific Viruses
#101Methods and compositions to reduce oxidative stress
#102COMPOSITIONS AND METHODS OF TREATING CANCER
#103Yeast-MUC1 immunotherapeutic compositions and uses thereof
#104Methods and systems for augmenting immune system responses
#105METABOLIC DRUG LOADING OF EVs
#106Drug composition for angiogenesis therapy
#107Dash inhibitors, and uses related thereto
#108Extracellular matrix compositions for the treatment of cancer
#109Conditioned stem cell-derived extract
#110C3D cellular and acellular vaccines for the prevention and treatment of cancer
#111Compositions comprising secreted extracellular vesicles of cells expressing NFATC4 useful for the treatment of cancer
#112Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer
#113Method for vacuum-assisted preservation of biologics including vaccines
#114Isolation of extracellular vesicles (EVs) from red blood cells for gene therapy
#115Therapeutic cancer vaccine based on stress proteins rendered immunogenic
#116Cell derived extracellular vesicles for the treatment of diseases
#117Methods and devices for stimulating an immune response using nanosecond pulsed electric fields
#118Reoviruses having modified sequences
#119TRANSINFECTED LYMPHOCYTES FOR ANTI-TUMOR THERAPY
#120METHODS OF TREATING CANCER
#121Inoculation by applying nanosecond pulsed electric fields to a biopsy and reintroducing the treated biopsy to the subject
#122Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer
#123COMPOSITIONS AND METHODS OF TREATING ACUTE MYELOID LEUKEMIA
#124Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins
#125Oncolytic virus formulation and preparation method thereof
#126Furin-knockdown and GM-CSF-augmented (FANG) cancer vaccine
#127COMBINATION OF PHARMACEUTICAL PREPARATIONS FOR TUMOR CHEMOTHERAPY
#128Progressively tumorigenic cell lines
#129Minor histocompatibility antigens and uses thereof
#130Extracellular vesicles for agent delivery
#131Autologous tumor vaccines and methods
#132METHOD FOR AMELIORATING AND ABATING SYMPTOMS RESULTING FROM RHEUMATOID ARTHRITIS, FIBROMYALGIA, AND CHRONIC PAIN OF UNKNOWN ORIGIN
#133Vaccination methods
#134Vaccines and vaccine components for inhibition of microbial cells
#135Methods and compositions for natural killer cells
#136METHOD FOR RECONSTITUTING TUMOR WITH MICROENVIRONMENT
#137Culture medium
#138Methods and compositions to reduce oxidative stress
#139Autologous implantation of chimeric murine-human tumors, generated in PDX mice, for ativation of an anti-tumor immune response in the donor patient
#140Yeast-MUC1 immunotherapeutic compositions and uses thereof
#141Inoculation by Applying Nanosecond Pulsed Electric Fields to a Biopsy and Reintroducing the Treated Biopsy to the Subject
#142Complexes of IL-15 and IL-15Ralpha and uses thereof
#143METHODS OF CELLULAR REPROGRAMMING
#144ANTI-ADDICTIVE COMPOSITION
#145Adenovirus derived helper virus for enhancing recombinant parvovirus production
#146Extracellular matrix compositions for the treatment of cancer
#147In vivo priming of natural killer cells
#148MicroRNAs 206 and 21 cooperate to promote RAS-extracellular signal-regulated kinase signaling by suppressing the translation of RASA1 and SPRED1
#149COMBINATION OF PHARMACEUTICAL PREPARATIONS FOR TUMOR CHEMOTHERAPY
#150THERAPEUTIC CANCER VACCINE BASED ON STRESS PROTEINS RENDERED IMMUNOGENIC
#151INDUCTION OF CELLULAR SENESCENCE FOR TISSUE THERAPIES
#152dhS1P AND USE OF SAME AS AN ANTICANCER THERAPEUTIC AND IMMUNOMODULATOR
#153Methods and compositions for treating prostate cancer or inducing a humoral immune response against prostate cancer
#154CORRELATES OF EFFICACY RELATING TO TUMOR VACCINES
#155Chimeric newcastle disease viruses and uses thereof
#156HIGH PURITY OVARIAN CANCER STEM CELLS FOR ACTIVE AUTOLOGOUS IMMUNE THERAPY
#157Cupredoxin derived transport agents and methods of use thereof
#158Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins
#159Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer
#160Therapeutic compositions and methods for treating infections
#161Osmotic drying of all-aqueous emulsions
#162Furin-knockdown and GM-CSF-augmented (FANG) cancer vaccine
#163Immune effector cells pre-infected with oncolytic virus
#164Diffusible factors and cancer cells
#165Extracellular matrix compositions for the treatment of cancer
#166Rapid Method Production High Purity Cancer Stem Cells and Population of High Purity Cancer Stem Cells
#167Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer
#168AUTOLOGOUS TUMOR VACCINES AND METHODS
#169Method for producing viral vector
#170Combined measles-malaria vaccine
#171Methods and compositions to reduce oxidative stress
#172Methods and Compositions Involving Induced Senescent Cells for Cancer Treatment
#173Compositions and methods for cancer immunotherapy
#174Method for producing multipolar cell
#175Method for producing multipolar cell
#176Cancer immunotherapy
#177Neuron generation, regeneration and protection
#178Antigen presenting cancer vaccine
#179ANTIGEN PRESENTING CANCER VACCINE WITH GAMMA INTERFERON
#180Silica-matrix forming compositions, materials formed therefrom, and methods of using the same
#181Method of generating tumor-specific T cells
#182dhS1P AND USE OF SAME AS AN ANTICANCER THERAPEUTIC AND IMMUNOMODULATOR
#183Genetically-engineered newcastle disease virus as an oncolytic agent, and methods of using same
#184Reoviruses having modified sequences
#185Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase
#186Chimeric Newcastle disease viruses and uses thereof
#187FILIP1L nucleic acid fragments
#188METHODS FOR TREATING MICA-RELATED DISORDERS
#189Cupredoxin derived transport agents and methods of use thereof
#190Pharmaceutical preparation for tumor chemotherapy and method for producing the same
#191Methods of treating cancer
#192Tumor specific promoter and oncolytic virus vector comprising the same
#193Method for vacuum-assisted preservation of biologics including vaccines
#194Immune effector cells pre-infected with oncolytic virus
#195Cupredoxin derived transport agents and methods of use thereof
#196Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins
#197Pharmaceutical composition of killed cells with substantially retained immunogenicity
#198Compositions and Methods for Enhancing Antigen-Specific Immune Responses
#199Herpes simplex viruses and methods of viral replication
#200Drug comprising as the active ingredient proliferative vector containing survivin promoter
#201Methods and compositions to reduce oxidative stress
#202IMMUNIZATION TO REDUCE NEUROTOXICITY DURING TREATMENT WITH CYTOLYTIC VIRUSES
#203DRUG COMPOSITION FOR ANGIOGENESIS THERAPY
#204Viruses for the treatment of cellular proliferative disorders
#205Cell Cycle Arrest and Apoptosis
#206Combined measles-malaria vaccine
#207Nucleic Acid Encoding TGEV and PRRSV Sequences for Improved Expression of PRRSV Sequences
#208Neuron generation, regeneration and protection
#209Anti-tumor/cancer heterologous acellular collagenous preparations and uses thereof
#210Chimeric Newcastle disease viruses and uses thereof
#211Vaccination methods
#212Recombinant adenovirus target-oriented co-expressing human p53 and p53aip1
#213Compositions to Treat Cardiac Pacing Conditions
#214Recombinant Bacteriophages Useful for Tissue Engineering
#215Systems and Methods to Treat Cardiac Pacing Conditions
#216Methods for treating cardiac pacing conditions
#217ENTRAPPED STEM CELLS AND USES THEREOF
#218Recombinant vaccinia virus having hepatitis C virus gene
#219Furin-knockdown and GM-CSF-augmented (FANG) cancer vaccine
#220Method of producing a pharmacologically stable form of lyophilised, active preparations of purified bacteriophages
#221IMMUNOMODULATING TUMOR NECROSIS FACTOR RECEPTOR 25 (TNFR25) AGONISTS, ANTAGONISTS AND IMMUNOTOXINS
#222Detection and destruction of cancer cells using programmed genetic vectors
#223Generation of replication competent viruses for therapeutic use
#224Therapeutic agent for malignant mesothelioma and immunostimulant
#225METHODS AND COMPOSITIONS FOR CANCER THERAPY USING A NOVEL ADENOVIRUS
#226Viral strains derived from the vaccinia virus Lister VACV-107 and uses thereof
#227METHOD OF TREATING HEARING LOSS USING XIAP
#228Attenuated live vaccines
#229ADENOVIRUS TARGETING
#230Ovarian Tumor Tissue Cell Preparations/Vaccines for the Treatment/Inhibition of Ovarian Tumors and Ovarian Cancer
#231Methods for effectively coexpressing IL-12 and IL-23
#232von Willebrand factor or factor VIII and von Willebrand factor for the treatment of coagulopathy induced by inhibitors of thrombocytes
#233RECOMBINANT HERPESVIRUS OF TURKEYS ENCODING FOR INTERLEUKIN-12
#234NON-INTEGRATING REV-DEPENDENT LENTIVIRAL VECTOR AND METHODS OF USING THE SAME
#235Extracellular matrix compositions for the treatment of cancer
#236Bacteriophage/Quantum-Dot (Phage-QD) Nanocomplex to Detect Biological Targets in Clinical and Environmental Isolates
#237Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyltransferase
#238Cell expressing complexes of IL-15 and IL-15Ralpha
#239Attenuated live triple G protein recombinant rabies virus vaccine for pre- and post-exposure prophylaxis of rabies
#240Filipil compositions and methods for treating cancer
#241RECOMBINANT MODIFIED VACCINIA VIRUS MEASLES VACCINE
#242Reoviruses having modified sequences
#243Methods for cancer treatment using stem cells
#244PROCESS FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS, RHEUMATOID ARTHRITIS, TREMORS/PARKINSON'S DISEASE, MULTIPLE SCLEROSIS, NON-VIRAL BASED CANCERS, ALZHEIMERS'S DISEASE, MUSCULAR DYSTROPHY, ATTENTION DEFICIT DISORDER, ATTENTION DEFICIT HYPERACTIVITY DISORDER, COMPLEX REGIONAL PAIN SYNDROME, DIABETES, NEUROPATHIC PAIN, SPIDER ARTHRITIS, WEST NILE VIRUS, FIBROMYALGIA, SHINGLES, GOUT, MIGRAINE HEADACHES, SENILE DEMENTIA, POST POLIO SYNDROME, CENTRAL VIRUS DEAFNESS, ASTHMA, CHRONIC PAIN OF UNKNOWN ORIGIN AND HEPATITIS C
#245Flaviviridae mutants comprising a deletion in the capsid protein for use as vaccines
#246Protection of virus particles from phagocytosis by expression of CD47
#247CHIMERIC OSTEOGENIC FACTOR CONTAINING PROTEINS CAPABLE OF INCREASED NUCLEAR LOCALIZATION AND METHODS OF USE THEREOF
#248Reoviruses
#249Chimeric flavivirus vaccines
#250Bacteriophage with Enhanced Lytic Activity
#251Methods of expressing LIM mineralization protein in non-osseous cells
#252Recombinant adenovirus useful for treating malignancy over-expressing proto-oncogene neu/erb B2
#253Vaccines and vaccine components for inhibition of microbial cells
#254Phage φmru polynucleotides and polypeptides and uses thereof
#255Cell-permeabilising peptides and polypeptides for microbial cells
#256virus
#257Cupredoxin derived transport agents and methods of use thereof
#258Viruses for the treatment of cellular proliferative disorders
#259Persistently infective vector
#260Novel Bacteriophage and Antibacterial Composition Comprising the Same
#261Methods and compositions for treating prostate cancer or inducing a humoral immune response against prostate cancer
#262Generation of oncolytic adenoviruses and uses thereof
#263Extracellular matrix compositions for the treatment of cancer
#264Adenovirus with mutations in the endoplasmic reticulum retention domain of the E3-19K protein and their use in cancer treatment
#265Chimeric osteogenic factor containing proteins capable of increased nuclear localization and methods of use thereof
#266Photodynamic therapy-generated mesothelioma vaccine
#267METHODS FOR TREATING MICA-RELATED DISORDERS
#268Herpes simplex viruses and methods of viral replication
#269Vaccine for porcine reproductive and respiratory syndrome, a preparion method and use thereof
#270Hybrid cells for treating cancer patients
#271Method for Detection of Cancer Cells Using Virus
#272Methods and compositions for cancer therapy using a novel adenovirus
#273HYBRID ADENO-RETROVIRAL VECTOR FOR THE TRANSFECTION OF CELLS
#274Chinese medicine composition and preparation method and use thereof
#275Process of production of bacteriophage compositions and methods in phage therapy field
#276Generation of Replication Competent Viruses for Therapeutic Use
#277Mutant Herpes Simplex Viruses Comprising Nucleic Acid Encoding A Nitroreductase
#278Nucleic acids encoding TGEV and PRRSV sequences for improved expression of PRRSV sequences
#279ANTIVIRAL ACTIVITY OF CIDOFOVIR AGAINST ONCOLYTIC VIRUSES
#280Drug comprising as the active ingredient proliferative vector containing survivin promoter
#281Genetically-engineered newcastle disease virus as an oncolytic agent, and methods of using same
#282Adenovirus vectors containing cell status-specific response elements and methods of use thereof
#283HSV with a Musashi promoter regulating γ34.5 and ribonucleotide reductase expression
#28444 Human Secreted Proteins
#285Combination therapy of hybrid cells with BCG injection for treating Cancer Patients
#286bacteriophage and uses thereof
#287REOVIRUSES HAVING MODIFIED SEQUENCES
#288Dengue virus mutant strain MBU 01-2002
#289Highly Attenuated Pox Virus Strains, Method for the Production Thereof and the Use Thereof as Paramunity Inducers or For Producing Vector Vaccines
#290Cell cycle arrest and apoptosis
#291Influenza B viruses with reduced sensitivity to neuraminidase inhibitors
#292MUTANT REOVIRUSES AND METHODS OF MAKING AND USING
#293Retroviral vector
#294Recombinant virus comprising an intact tumor-therapeutic antibody with human constant regions and the use thereof
#295Reoviruses having modified sequences
#296Medicine for Treating Tumor and Use Therefor in Preparation of the Medicaments for Treating Tumor
#297Adenovirus vectors containing cell status-specific response elements and methods of use thereof
#298Adenovirus vectors containing cell status-specific response elements and methods of use thereof
#299Chimeric osteogenic factor containing proteins capable of increased nuclear localization and methods of use thereof
#300Adenovirus vectors containing cell status-specific response elements and methods of use thereof