20908 ⎘
Medicinal preparations containing peptides; Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
Method and system for treating wounds
#602PEPTIDE-AND AMINE-MODIFIED GLUCAN PARTICLES FOR DELIVERY OF THERAPEUTIC CARGOES
#603PHARMACEUTICAL COMPOSITIONS FOR INTRAOCULAR ADMINISTRATION AND METHODS FOR FABRICATING THEREOF
#604Pharmaceutical compositions and related methods of delivery
#605Probiotic recolonisation therapy
#606Probiotic recolonisation therapy
#607Probiotic recolonisation therapy
#608Probiotic recolonisation therapy
#609Prodrugs activated by caspase
#610NUTRACEUTICAL COMPOSITION AND METHODS FOR PREVENTING OR TREATING MULTIPLE SCLEROSIS
#611Methods and Compositions for Treating Clostridium difficile Associated Disease
#612Tunable anti-microbial loaded hydrogels
#613Extracellular matrix-binding synthetic peptidoglycans
#614COMPOSITIONS AND METHODS FOR TREATMENT OF CARDIOVASCULAR DISEASE
#615Chemical structures for localized delivery of therapeutic agents
#616Anti-infective hydroxy-phenyl-benzoates and methods of use
#617Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections
#618ENVIRONMENTAL CLOSTRIDIAL BACTERIOTHERAPY AND RELATED FORMULATIONS AND METHODS OF MANUFACTURE AND USE
#619Method for therapeutic replenishment and enrichment of ocular surface lubrication
#620TREATMENT AND PREVENTION OF BACTERIAL SKIN INFECTIONS USING ORITAVANCIN
#621Formulations of vancomycin
#622PHARMACEUTICAL COMPOSITIONS FOR INTRAOCULAR ADMINISTRATION AND METHODS FOR FABRICATING THEREOF
#623Bone targeted therapeutics and methods of making and using the same
#624Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
#625COMPOSITIONS AND METHODS FOR TREATING MICROBIOTA-RELATED PSYCHOTROPIC CONDITIONS AND DISEASES
#626Dry powder vancomycin compositions and associated methods
#627Combination Therapy for Subcutaneous Administration of Glycopeptide Antibiotics
#628Pharmaceutical composition for treating a microbial infection
#629Biomarker for detecting white matter stroke, containing toll-like receptor 2, and medical use of toll-like receptor 2
#630HUMANIZED ANTIBODIES SPECIFIC FOR STAPHYLOCOCCAL ENTEROTOXIN B
#631Endolysins active against bacteria, pharmaceutical compositions, and methods relating thereto
#632Methods of diagnosis, selection, and treatment of diseases and conditions caused by or associated with methanogens
#633Cholestosome vesicles for incorporation of molecules into chylomicrons
#634PREPARATION AND CHARACTERIZATION OF BONE-TARGETED VANCOMYCIN-LOADED LIPOSOMES FOR OSTEOMYELITIS TREATMENT
#635Substituted imidazopyridazines
#636Therapeutic modulation of ocular surface lubrication
#637Topical vancomycin formulation and methods of use
#638High purity oritavancin and method of producing same
#6394-CYANO-N-(2-(4,4-DIMETHYLCYCLOHEX-1-EN-1-YL)-6-(2,2,6,6-TETRAMETHYLTETRAHYDRO-2H-PYRAN-4-YL)PYRIDIN-3-YL)-1H-IMIDAZOLE-2-CARBOXAMIDE FOR THE TREATMENT OF HODGKIN'S LYMPHOMA
#640Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
#641Methods for producing a biodegradable chitosan composition and uses thereof
#642Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
#643Stable nocathiacin lyophilized injection agent
#644Peptide compounds and methods of production and use thereof
#645Combination Therapy for the Treatment of Nosocomial Pneumonia
#646Methods and compositions for treating associated disease
#647Technology for the Preparation of Microparticles
#648Method Of Treating An Ocular Disease And Compositions Effective For Treating An Ocular Disease
#649Use of levocetirizine and montelukast in the treatment of traumatic injury
#650Compositions and methods for treating and preventing infections
#651NOD2-DEPENDENT PATHWAY OF CYTOPROTECTION OF STEM CELLS
#652PHARMACEUTICAL COMPOSITIONS COMPRISING GELS AND METHODS FOR FABRICATING THEREOF
#653Enteric combination therapy
#654Stabilized vancomycin formulations
#655Dry pharmaceutical compositions for topical delivery of oral medications, nasal delivery and to treat ear disorders
#656Near-Infrared Electromagnetic Modification of Cellular Steady-State Membrane Potentials
#657Phospholipid depot
#658Probiotic recolonisation therapy
#659Probiotic recolonisation therapy
#660Probiotic recolonisation therapy
#661Complex-formation-modulating agents and uses therefor
#662Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines
#663Bacteriophage lysin and antibiotic combinations against gram positive bacteria
#664Methods and devices for bone infection treatment selection
#665Antimicrobial articles produced by additive manufacturing
#666Pharmaceutical composition for the preparation of infusion solutions of antimicrobial preparations, its production process (variations)
#667Methods and compositions for administering an active agent to the pleura of a patient
#668Administration of antibiotics and therapeutic agents
#669Probiotic recolonisation therapy
#670Spray drying vancomycin
#671Antimicrobial compositions comprising a hyaluronic acid binding peptide and a β-lactam antibiotic
#672Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
#673Compounds for the treatment of associated disease
#674Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
#675Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
#676Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
#677Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
#678Dendritic polypeptide-based nanocarriers for the delivery of therapeutic agents
#679Antimicrobial Composition for the Treatment of Methicillin-resistant Staphylococcus aureus
#680MULTI-LAYER CAPSULE AND MANUFACTURE METHOD THEREOF
#681Pediatric oral liquid compositions containing nepadutant
#682PHARMACEUTICAL COMPOSITIONS FOR INTRAOCULAR ADMINISTRATION AND METHODS FOR FABRICATING THEREOF
#683Methods of treating hepatic encephalopathy
#684Ocular composition and method
#685Compositions and methods for treating clostridium infection and preventing recurrence of infection
#686Methods for treating lung infections and inflammation
#687METHOD AND COMPOSITION FOR TREATING CANCER
#688MODULATORS OF CANDIDA HYPHAL MORPHOGENESIS AND USES THEREOF
#689Cationic Liposomal Drug Delivery System for Specific Targeting of Human CD14+ Monocytes in Whole Blood
#690EMP2 REGULATES ANGIOGENESIS IN CANCER CELLS THROUGH INDUCTION OF VEGF
#691Therapeutic applications of calcium electroporation to effectively induce tumor necrosis
#692Methods of treating necrotizing enterocolitis by administering nuclear oligomerization domain-2 agonists,TLR9 agonists and TLR4 antagonists
#693Microbiota restoration therapy (MRT), compositions and methods of manufacture
#694COMPOSITIONS OF PENETRATION-ENHANCED TARGETING PROTEINS AND METHODS OF USE
#695Isolation, identification, and uses of antifungal compounds
#696Multivalent vaccine protection from infection
#697Synthetic mechanical hemostatic composition, method of making and use thereof
#698Isolation, identification, and uses of antifungal compounds
#699Prevention of infection
#700Dry pharmaceutical compositions for topical delivery of oral medications, nasal delivery and to treat ear disorders
#701Methods for treating gastrointestinal disorders associated with Parkinson's disease, autism, diabetic gastroparesis
#702Recombinant Trivalent Vaccine Against Human Influenza
#703Anti-infective hydroxy-phenyl-benzoates and methods of use
#704Mycophenolic acid analogues as anti-tumor chemosensitizing agents
#705Methods of treating gram-negative microbial infections
#706Method of determining types I, II, III, IV or V or methicillin-resistant (MRSA) in a biological sample
#707Administration of antibiotics and therapeutic agents
#708BIODEGRADABLE THERAPEUTIC NANOPARTICLES CONTAINING AN ANTIMICROBIAL AGENT
#709Hydrochloride salts of a glycopeptide-cephalosporin antbiotic compond
#710Anti-biofilm compositions and methods for using
#711Use of Antibiotics to Enhance Treatment With Therapeutic Viruses
#712Method and system for producing high purity vancomycin hydrochloride
#713In Situ Forming Hydrogel and Method Using Same
#714Encochleation methods, cochleates and methods of use
#715Probiotic, Lactic Acid-Producing Bacteria and Uses Thereof
#716Pharmaceutical compounds for use in the therapy of infection
#717Spray drying vancomycin
#718SETTING OF HARDENABLE BONE SUBSTITUTE
#719Compositions and methods for probiotic recolonization therapies
#720Fecal lactoferrin as a biomarker for determining disease severity and for treating infection in patients with disease
#721Controlling appetite, promoting weight loss, reducing body fat, and/or improving glucose tolerance
#722Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
#723Controlled release method for a pharmaceutical composition composed of chelating complex micelles
#724LIPOSOMAL VANCOMYCIN FOR THE TREATMENT OF MRSA INFECTIONS
#725SUPPRESSION OF TOXIN PRODUCTION OF CLOSTRIDIUM DIFFICLE
#726Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
#727USE OF STORAGE STABLE VISCOUS PHOSPHOLIPID DEPOT TO TREAT WOUNDS
#728Antimicrobial compositions for treating microbial infections
#729Pharmaceutical composition for the preparation of infusion solutions of antimicrobial preparations, its production process (variations)
#730Method of inhibiting by administration of oritavancin
#731Method and System for Treatment of Biological Tissue
#732Dry powder vancomycin compositions and associated methods
#733Antibodies that specifically bind alpha toxin and methods of use
#734Bone targeted therapeutics and methods of making and using the same
#735NOVEL AZACOUMARIN DERIVATIVES HAVING MDR PUMP INHIBITING ACTIVITY
#736Glycopeptide phosphonate derivatives
#737Angiopoietin derived peptides
#738NEAR-INFRARED ELECTROMAGNETIC MODIFICATION OF CELLULAR STEADY-STATE MEMBRANE POTENTIALS
#739Method of inhibiting clostridium difficile by administration of oritavancin
#740Compounds for the treatment of -associated disease
#741Bacteriophage lysin and antibiotic combinations against gram positive bacteria
#742Structural and mechanistic basis for novel compound biosynthesis using 4-electron hexose oxidase
#743Broad spectrum antibiotic arylomycin analogs
#744TREATMENT OF DISEASE ASSOCIATED WITH THE USE OF ANTIBIOTICS
#745Synthetic mechanical hemostatic composition, method of making and use thereof
#746Compositions for probiotic recolonisation therapy
#747Pharmaceutical composition and method of treating a microbial infection with sulcotidil
#748USE OF LEUKOTRIENE B4 IN COMBINATION WITH A TOLL-LIKE RECEPTOR LIGAND, A RIG-I-LIKE RECEPTOR LIGAND, OR A NOD-LIKE RECEPTOR LIGAND TO ENHANCE THE INNATE IMMUNE RESPONSE
#749Combination Of An Aminoacyl-tRNA Synthetase Inhibitor With A Further Antibacterial Agent For Attenuating Multiple Drug Resistance
#750Environmental Clostridial Bacteriotherapy and Related Formulations and Methods of Manufacture and Use
#751Drug Release from a Polymer-Controlled Local Antibiotic Delivery System Using a Degradable Bone Graft
#752Methods for Fructanase and Fructokinase Inhibition
#753METHODS OF TREATMENT USING SINGLE DOSES OF ORITAVANCIN
#754BISMUTH-THIOLS AS ANTISEPTICS FOR EPITHELIAL TISSUES, ACUTE AND CHRONIC WOUNDS, BACTERIAL BIOFILMS AND OTHER INDICATIONS
#755Methods of treating hepatic encephalopathy
#756ANTIMICROBIAL COMPOUNDS
#757Formulation of PEGylated-liposome encapsulated glycopeptide antibiotics
#758Substituted triazolopyridines
#759HYDROPHOBICALLY-MODIFIED HYALURONAN AND METHODS OF MAKING AND USING THEREOF
#760Method and pharmacological composition for the diagnosis and treatment of male sub-fertility
#761Substituted tetracycline compounds for treatment of infections
#762Metal-containing materials for treatment of bacterial conditions
#763COMPOUNDS FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE-ASSOCIATED DISEASE
#764Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
#765Composition for modulating inflammation of cardiovascular tissue
#766Spray drying vancomycin
#767SUSTAINED DRUG RELEASE FROM BODY IMPLANTS USING NANOPARTICLE-EMBEDDED POLYMERIC COATING MATERIALS
#768Glycopeptide phosphonate derivatives
#769FECAL LACTOFERRIN AS A BIOMARKER FOR DETERMINING DISEASE SEVERITY AND FOR TREATING INFECTION IN PATIENTS WITH CLOSTRIDIUM DIFFICILE DISEASE
#770FECAL LACTOFERRIN AS A BIOMARKER FOR DETERMINING DISEASE SEVERITY AND FOR MONITORING INFECTION IN PATIENTS WITH CLOSTRIDIUM DIFFICILE DISEASE
#771TREATMENT OF ONCOLOGICAL DISEASES
#772GENETIC MARKERS ASSOCIATED WITH RESPONSE TO CYCLOPHILIN-BINDING COMPOUNDS
#773Treatment of cardiovascular disease and thrombosis
#774Therapy for enteric infections
#775Method of administration of platelet-rich plasma to treat an acute cardiac dysfunction
#776Probiotic, lactic acid-producing bacteria
#777METHOD AND COMPOSITION FOR TREATING CANCER
#778Compositions and methods for delivering an agent to a wound
#779Glycopeptide and lipoglycopeptide antibiotics with improved solubility
#780METHOD AND DEVICE FOR TREATING MICROSCOPIC TUMORS REMAINING IN TISSUES FOLLOWING SURGICAL RESECTION
#781Technology for the Preparation of Microparticles
#782MRSA bactericidal topical gel
#783Method for determining predisposition to pulmonary infection
#784Structural and mechanistic basis for novel compound biosynthesis using the 4-electron hexose oxidase
#785Films and particles
#786COLLAGEN-BINDING SYNTHETIC PEPTIDOGLYCANS FOR WOUND HEALING
#787Derivatives of APF and methods of use
#788Pharmaceutical compositions and related methods of delivery
#789USE OF ALKANOYL L-CARNITINE IN COMBINATION WITH CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF NEOPLASMS
#790INTERLACED METHOD FOR TREATING CANCER OR A PRECANCEROUS CONDITION
#791Anti-biofilm compositions and methods for using
#792Use of toll-like receptor-9 agonists
#793INFERTILITY ASSOCIATED DEFB-126 DELETION POLYMORPHISM
#794Phospholipid depot
#795Anti-infective hydroxy-phenyl-benzoates and methods of use
#796COMPOSITION FOR THE TREATMENT OF OSTEOMYELITIS, METHOD FOR PREPARING THE SAME, AND METHOD FOR THE TREATMENT OF OSTEOMYELITIS
#797Methods of treating bacterial infections using oritavancin
#798CONSUMABLE DISSOLVING FILM COMPRISING ACTIVE INGREDIENTS DERIVED FROM BACTERIA AND FUNGI
#799Seroma Control for Surgical Patients
#800LIPOSOMES FOR DRUG DELIVERY AND METHODS FOR PREPARATION THEREOF
#801Pharmaceutical compositions and related methods of delivery
#802Method of determining types I, II, III, IV or V or methicillin-resistant (MRSA) in a biological sample
#803PHARMACEUTICAL COMPOSITIONS AND METHODS OF DELVERY
#804Treatment of celiac disease with IgA
#805Administration of antibiotics and therapeutic agents
#806COMPOUNDS AND METHODS FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASE
#807ANTIBIOTIC THERAPY TO REDUCE THE LIKELIHOOD OF DEVELOPING POST-INFECTIOUS IRRITABLE BOWEL SYNDROME
#808PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS OF DELIVERY
#809Method for manufacturing a porous ceramic scaffold having an organic/inorganic hybrid coating layer containing a bioactive factor
#810METHODS OF TREATING HEPATIC ENCEPHALOPATHY
#811BIODEGRADABLE THERAPEUTIC NANOPARTICLES CONTAINING AN ANTIMICROBIAL AGENT
#812Combination therapy and methods for treating bacterial biofilms
#813Angiopoietin derived peptides
#814Methods of treatment using single doses of oritavancin
#815ERYTHROPOIETIN AMELIORATES CHEMOTHERAPY-INDUCED TOXICITY IN VIVO
#816Methods of treating autoimmune diseases caused by small intestinal bacterial overgrowth
#817Alpha-dystroglycan as a Protein Therapeutic
#818Films and particles
#819METHODS AND MATERIALS FOR GASTROINTESTINAL DELIVERY OF PATHOGEN/TOXIN BINDING AGENTS
#820Ophthalmic device, and method of use thereof, for increasing ocular boundary lubrication
#821Photokinetic ocular drug delivery methods and apparatus
#822USE OF RIFALAZIL TO TREAT COLONIC DISORDERS
#823Conjugated molecules comprising a peptide derived from the CD4 receptor coupled to a polyanion for the treatment of AIDS
#824Therapeutic modulation of ocular surface lubrication
#825Compositions for treating dry eye disease
#826Methods of inhibiting and treating biofilms using glycopeptide antibiotics
#827Method and pharmacological composition for the diagnosis and treatment of male
#828Probiotic, lactic acid-producing bacteria and uses thereof
#829Probiotic, lactic acid-producing bacteria and uses thereof
#830Nutraceutical Composition and Methods for Preventing or Treating Multiple Sclerosis
#831Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications
#832Nutraceutical composition and methods for preventing or treating multiple sclerosis
#833Method of inhibiting clostridium difficile by administration of oritavancin
#834IMMUNOMODULATORY POLYMERIC ANTIGENS FOR TREATING INFLAMMATORY PATHOLOGIES
#835Use of muramyl dipeptide (MDP) for treating inflammation
#836TREATMENT OF PULMONARY DISORDERS WITH AEROSOLIZED MEDICAMENTS SUCH AS VANCOMYCIN
#837Functional nanoparticle-based antibiotics and preparation method thereof
#838VANCOMYCIN AND TEICOPLANIN ANHYDROUS FORMULATIONS FOR TOPICAL USE
#839USE OF THE STAUDINGER LIGATION IN IN VIVO ASSEMBLY OF A BIOLOGICALLY ACTIVE COMPOUND
#840Recombinant poly-glutamic acid depolymerases
#841Dehydroxy vancomycin, the preparation, pharmaceutical composition and the use
#842METHODS OF TREATING HEPATIC ENCEPHALOPATHY
#843Methods of generating, repairing and/or maintaining connective tissue in vivo
#844Anionic Polymers as Toxin Binders and Antibacterial Agents
#845Glycopeptide phosphonate derivatives
#846PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS OF DELIVERY
#847MRSA Bactericidal Topical Gel
#848Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
#849Pre-Surgical Prophylactic Administration of Antibiotics and Therapeutic Agents
#850BLEOMYCIN PREPARATION FOR USE AGAINST SKIN TUMOURS
#851Combination therapy for the treatment of bacterial infections
#852Use of oritavancin for prevention and treatment of anthrax
#853BIOMATERIAL
#854Methods of treating diarrhea caused by small intestinal bacterial overgrowth
#855Antibiotic combinations for providing total solution to the treatment of infections
#856Method for treating cervical cancer
#857Antimicrobial therapy for bacterial infections
#858DALBAVANCIN COMPOSITIONS FOR TREATMENT OF BACTERIAL INFECTIONS
#859METHODS OF ADMINISTERING DALBAVANCIN FOR TREATMENT OF BACTERIAL INFECTIONS
#860USE OF INTERLEUKIN-19 TO TREAT CERVICAL CANCER
#861THERAPY FOR HUMAN CANCERS USING CISPLATIN AND OTHER DRUGS OR GENES ENCAPSULATED INTO LIPOSOMES
#862COMPOSITIONS AND METHODS FOR INHIBITING TOXIN A FROM CLOSTRIDIUM DIFFICILE
#863INTRAOCULAR IRRIGATING SOLUTION HAVING IMPROVED FLOW CHARACTERISTICS
#864Modulators of hyphal morphogenesis and uses thereof
#865Bone targeted therapeutics and methods of making and using the same
#866USE OF A POLYENE MACROLIDE ANTIFUNGAL AGENT IN COMBINATION WITH A GLYCOPEPTIDE ANTIBACTERIAL AGENT
#867Compositions and methods for treating bacteria
#868Method for preventing and/or treating peripheral Neuropathies induced by the administration of an anticancer agent
#869PROCESS FOR REDUCING EFFECTS OF GRAFT VERSUS HOST DISEASE USING EX VIVO EXPANDED CD4+CD25+ REGULATORY T CELLS
#870Method for preventing and/or treating peripheral neuropathies induced by the administration of an anticancer agent
#871Orally-Absorbed Solid Dose Formulation for Vancomycin
#872Methods of Treating Pulmonary Disorders using Liposomal Vancomycin Formulations
#873Liposomal Vancomycin Formulations
#874Technology for the Preparation of Microparticles
#875Method for determining predisposition to pulmonary infection
#876USE OF DNA-PK INHIBITION TO SENSITISE ATM DEFICIENT CANCERS TO DNA-DAMAGING CANCER THERAPIES
#877Methods of treating a subject suffering from irritable bowel syndrome
#878Glycopeptide phosphonate derivatives
#879Medical Devices and Coatings Therefor
#880Modulators Of NOD2 Signalling
#881METHOD AND COMPOSITION FOR TREATING CANCER
#882Compositions and minimally invasive methods for treating peripheral vascular disease
#883METHOD OF TREATING ACUTE DYSFUNCTION OF CARDIAC MUSCLE
#884METHOD OF TREATING INJURED CARDIAC TISSUE
#885METHOD OF TREATING CHRONIC DYSFUNCTION OF CARDIAC MUSCLE
#886Wound and cutaneous injury healing with a nucleic acid encoding a proteoglycan polypeptide
#887Probiotic, lactic acid-producing bacteria and uses thereof
#888Medicament for preventing and/or treating peripheral neuropathies
#889CANCER TREATMENT METHODS USING CADHERIN ANTAGONISTS IN COMBINATION WITH ANTICANCER AGENTS
#890Antibiotic product formulation
#891Methods for treating conditions associated with the accumulation of excess extracellular matrix
#892Releasable linkage and compositions containing same
#893HUMAN SECRETORY IgA FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASES
#894Synthesis of human secretory IgA for the treatment of associated diseases
#895Synthesis of human secretory IgM and the treatment of clostridium difficile associated diseases herewith
#896Near-infrared electromagnetic modification of cellular steady-state membrane potentials
#897POLYMERIZABLE ANTIMICROBIAL COMPOSITION
#898Films and particles
#899ISOLATED LECTIN POLYPEPTIDES CONSISTING OF TRUNCATED MAMMALIAN UDP-GalNAc:POLYPEPTIDE N- ACETYLGALACTOSAMINYLTRANSFERASES
#900Intraocular Irrigating Solution Having Improved Flow Characteristics