Lipid nanoparticle compositions and methods for mRNA delivery

COMPOSITION COMPRISING AT LEAST ONE ENZYME AND AT LEAST ONE MICROBICIDAL MOLECULE FOR THE PREVENTION OR TREATMENT OF POST-IMPLANT INFECTIONS

Ionizable cationic lipids

Method of treatment of schizophreniform disorder

Methods and compositions for CNS delivery of heparan n-sulfatase

ACTIVE SELF-HEALING BIOMATERIAL SYSTEM

Lipid nanoparticle compositions and methods for mRNA delivery

Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same

Injectable, Non-Aqueous Suspension with High Concentration of Therapeutic Agent

Methods and compositions related to physiologically responsive microneedle delivery systems

METHOD FOR INCREASING THE BIOAVAILABILITY OF INHALED COMPOUNDS

Use of Acid Stable Proteases in Animal Feed, Preferably to Increase Performance of Cocc-Vaccinated Broiler Chickens

Structure, manufacturing and uses of human-derived cell-permeable peptides conjugated with specific biologically active cargo peptides

Lysin Agent and Method of Use for Diagnostic Testing

VSV/NDV hybrid viruses for oncolytic therapy of cancer

Process for encapsulating soluble biologics, therapeutics, and imaging agents

Immune modulation and treatment of solid tumors with antibodies that specifically bind CD38

TREATMENT OF ALZHEIMER'S DISEASE SUBPOPULATIONS WITH POOLED IMMUNOGLOBULIN G

Selective recovery

MRNA therapy for Pompe disease

Conjugates of biologically active molecules to functionalized polymers

Stabilization of biomolecules using sugar polymers

COMPOSITIONS, SYSTEMS, AND METHODS FOR SCAR TISSUE MODIFICATION

FEED ADDITIVE COMPOSITION

Compositions and methods for treating MPSI

Recombinant intravenous immunoglobulin (rIVIG) compositions and methods for their production and use

EVALUATION OF THE SEVERITY OF PATIENTS WITH FLAVIVIRUS INFECTION BY BLOOD HYALURONAN LEVELS AND THERAPEUTIC AGENTS TO BLOCK THE HYALURONAN

Glycosylation independent proteins

ANTIBODY FORMULATIONS CONTAINING AMINO ACIDS

Glycosidase regimen for the treatment of chronic viral infection

Use of hyaluronidase for the prevention or treatment of arterial hypertension or cardiac insufficiency

Intestinal flora improvement agent

Scavenger receptor uptake for Fabry disease enzyme replacement therapy

ENZYME REPLACEMENT THERAPY IN MUCOPOLYSACCHARIDOSIS IIIB PATIENTS

INTRAVENTRICULAR ENZYME DELIVERY FOR LYSOSOMAL STORAGE DISEASES

COMBINATION THERAPY WITH AN ANTI-HYALURONAN AGENT AND THERAPEUTIC AGENT

GLYCOGEN OR POLYSACCHARIDE STORAGE DISEASE TREATMENT METHOD

Feed additive composition

Devices and methods for the preparation of a nutritional formula

Activated polyoxazolines and conjugates and compositions comprising the same

Lysin polypeptides active against Gram-negative bacteria

Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity

Methods for the dietary management of irritable bowel syndrome and carbohydrate malabsorption

Technology for the Preparation of Microparticles

Chimeric bacteriophage lysin with activity against staphylococci bacteria

Excipient compounds for protein processing

Enzymes and methods for cleaving N-glycans from glycoproteins

Targeting of glycoprotein therapeutics

SIALYLATED GLYCOPROTEIN COMPOSITIONS AND USES THEREOF

Application of neuraminidase and inhibitors thereof in myocardial ischemia and myocardial infarction

MATERIALS AND METHODS FOR MITIGATING IMMUNE-SENSITIZATION

Methods and compositions for the treatment of steatosis-associated disorders

Cancer treatment

Intramolecular Trans-Sialidase

Secreted splicing variant of mammal Klotho as a medicament for cognition and behaviour impairments

Composition having antifungal activity

Compositions and Methods for Treating Acne

Glycoside hydrolases and their use in preventing and/or treating a pathogenic infection in an animal

PHARMACEUTICAL FORM FOR ORAL ADMINISTRATION OF A HIGHLY CONTROLLED AND STABLE DOSE OF NANOPARTICLES OR BIOMACROMOLECULE SUSPENSIONS

MYCOBACTERIUM LYSTERASE: A NOVEL TREATMENT FOR ACNE

Polynucleotides encoding alpha-galactosidase A for the treatment of Fabry disease

Polynucleotides encoding α-galactosidase A for the treatment of Fabry disease

POLYNUCLEOTIDES ENCODING ALPHA-GALACTOSIDASE A FOR THE TREATMENT OF FABRY DISEASE

DIETARY SUPPLEMENTS AND FORMULATIONS

DIETARY SUPPLEMENTS AND FORMULATIONS

Conjugates of tumor necrosis factor inhibitors to functionalized polymers

METHOD FOR DETECTING INFECTIOUS PARVOVIRUS IN PHARMACEUTICAL PREPARATIONS

USES OF ANTI-HER3 ANTIBODIES FOR TREATING CANCER

Nanosystems for controlled transport of active molecules for diagnostic, prognostic and therapeutic purposes

ENHANCED THERAPEUTIC USAGE OF A PURINE NUCLEOSIDE PHOSPHORYLASE OR NUCLEOSIDE HYDROLASE PRODRUG

High concentration alpha-glucosidase compositions for the treatment of pompe disease

Enzymatic replacement therapy and antisense therapy for pompe disease

Animal feed compositions and methods of use

Enzyme delivery systems and methods of preparation and use

Compositions and methods for internalizing enzymes

CLOSTRIDIUM DIFFICILE BACTERIOPHAGE LYSINS FOR DETECTION AND TREATMENT OF CLOSTRIDIUM DIFFICILE BACTERIA INFECTION

Agent for use in the case of fructose intolerance

ENZYME COMPOSITION FOR MANAGEMENT OF METABOLIC HEALTH

Novel Compositions for Preventing and/or Treating Lysosomal Storage Disorders

Methods and Compositions for the Treatment of Cytoplasmic Glycogen Storage Disorders

COMPOSITIONS AND METHODS COMPRISING SERRATIA PEPTIDASE FOR INHIBITION AND TREATMENT OF BIOFILMS RELATED TO CERTAIN CONDITIONS

ASSISTED ENZYME REPLACEMENT THERAPY

Method for Treating Pervasive Development Disorders

Method for enhancing folding and transport of misfolded glucocerebrosidase

Animal feed compositions and uses thereof

Subcutaneous HER2 antibody formulations

INTRANASAL THERAPEUTIC DELIVERY OF ADENO-ASSOCIATED VIRUS TO CENTRAL NERVOUS SYSTEM

Immunogenic compositions and reagents for preparing

PROCESS FOR CONCENTRATION OF A POLYPEPTIDE

METHODS TO TREAT CEROID LIPOFUSCINOSIS USING A RECOMBINANT ADENO-ASSOCIATED VIRUS

METHODS TO TREAT POMPE DISEASE USING A RECOMBINANT ADENO-ASSOCIATED VIRUS

ADENO-ASSOCIATED VIRUS MEDIATED GENE TRANSFER TO THE CENTRAL NERVOUS SYSTEM

Multi-functionalized polysaccharide compounds and use thereof for targeting the cation-independent mannose 6-phosphate receptor

ADENO-ASSOCIATED VIRUS MEDIATED GENE TRANSFER TO THE CENTRAL NERVOUS SYSTEM

Inhibition and treatment of gastrointestinal biofilms

Dimeric bacteriophage lysins

MULTI CHAMBER SYRINGE UNIT AND METHOD OF PREPARING A MULTI CHAMBER SYRINGE

Methods and compositions for improved cognition

METHODS AND COMPOSITIONS FOR TREATMENT OF POMPE DISEASE

Preparation and Use of Combination Enzyme and Gastrointestinal Modulator Delivery Systems

Endolysin polypeptide

NOVEL MODULATORS AND METHODS OF USE

Subcutaneous therapeutic enzyme formulations, uses, and methods for generating thereof

MRNA for use in treatment of human genetic diseases

Selective recovery

Subcutaneous anti-HER2 Antibody Formulations and Uses Thereof

Augmented acid alpha-glucosidase for the treatment of Pompe disease

Compositions and methods for treatment of Gcase related disease states

Progranulin (PGRN) fragments and derivatives for treatment or alleviation of lysosomal storage diseases

ENZYME REPLACEMENT THERAPY FOR MUCOPOLYSACCHARIDOSIS IIID

BACTERIOPHAGE LYSIN AND ANTIBIOTIC COMBINATIONS AGAINST GRAM POSITIVE BACTERIA

Method for the treatment of Pompe disease using 1-deoxynojirimycin derivatives

Anti-CD28 Humanized Antibodies Formulated for Administration to Humans

FORMULATION OF GLUCOSINOLATES AND MYROSINASE

Nanoparticles containing extracellular matrix for drug delivery

Process and composition for low dose insemination

COMPOSITIONS COMPRISING SULFORAPHANE OR A SULFORAPHANE PRECURSOR AND A MUSHROOM EXTRACT OR POWDER

Characterization of four prophage endolysins specific for clostridium perfringens

Ultrapure hypoallergenic solutions of sacrosidase

ANTI-VIRAL THERAPEUTIC FOR INFECTION OF THE EYE

MICROFABRICATED NANOPORE DEVICE FOR SUSTAINED RELEASE OF THERAPEUTIC AGENT

COMPOSITION AND/OR COMBINATION FOR AQUACULTURE

Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases

Chemical crosslinkers

THERAPEUTIC COMPOSITIONS OF ALPHA-L-IDURONIDASE, IDURONATE-2-SULFATASE, AND ALPHA-GALACTOSIDASE A AND METHODS OF USE THEREOF

Treatment of glycogen storage disease type II

Compositions and methods for altering tissue specificity and improving AAV9-mediated gene transfer

Use of Hsp70 as a regulator of enzymatic activity

Methods of improving animal performance

TREATMENT OF HUMAN METAPNEUMOVIRUS

Compositions for the Restoration of a Fecal Microbiota and Methods for Making and Using Them

Cleavable lipids

Method of diagnosing preeclampsia or pregnancy-induced hypertension

bitter taste removing preparation and method

Dosing Regimens For The Treatment Of Fabry Disease

Methods of reducing extravasation of inflammatory cells

Glucocerebrosidase gene therapy for Parkinson's disease

Endolysins Active Against Staphylococcus Bacteria, Pharmaceutical Compositions, and Methods Relating Thereto

Methods, Compounds, and Compositions For Treatment and Prophylaxis in the Respiratory Tract

Enzyme-treated milk product, preparation method thereof, composition, and products

COMPOSITION AND METHOD FOR PROMOTING REDUCTION OF HEAT STRESS IN ANIMALS

Use of thiazolide compounds for the prevention and treatment of viral diseases, cancer and diseases caused by intracellular infections

Lysosomal targeting peptides and uses thereof

Combination Therapies for CD38-Positive Hematological Malignances with ANTI-CD38 Antibodies and Cyclophosphamide

ENZYME COMPOSITION FOR THERAPEUTIC MANAGEMENT OF MUSCLE SORENESS

Fabry disease gene therapy

Reactive and sorbent materials

N-acetyl-alpha-D-glucosaminidase deficiency compositions and methods

Compositions and methods for the treatment or the prevention of infections and for the eradication or reduction of surfaces

STABILIZED COMPOSITIONS OF PROTEINS HAVING A FREE THIOL MOIETY

Methods to treat mucopolysaccharidosis type II or deficiency in iduronate-2-sulfatase using a recombinant adeno-associated virus (AAV) vector encoding iduronate-2-sulfatase

Therapeutic fusion protein comprising an alpha-n-acetylglucosaminidase and a lysosomal targeting moiety

COMBINATION THERAPY FOR TREATING PROTEIN DEFICIENCY DISORDERS

Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins and applications thereof

Methods and compositions for the treatment of symptoms of prion diseases

Composition for hypotonic lipolysis and manufacturing method thereof

Method of treating glycogen storage disease type IX using acid alpha-glucosidase

Intranasal administration of guanidinylated aminoglycosides

Methods and Compositions for the Treatment of Symptoms of Complex Regional Pain Syndrome

Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same

ADENO-ASSOCIATED VIRUS FOR THERAPEUTIC DELIVERY TO CENTRAL NERVOUS SYSTEM

Injection composition comprising hyaluronidase for removal of topical fat

Technology for preparation of macromolecular microspheres

Methods and compositions for CNS delivery of arylsulfatase A

Pharmaceutical composition for treating cancer comprising trypsinogen and/or chymotrypsinogen and an active agent selected from a selenium compound, a vanilloid compound and a cytoplasmic glycolysis reduction agent

Methods of treating dementia associated with Alzheimer's disease with protective protein/cathepsin A (PPCA)

Methods of generating anti-inflammatory stem cells

Targeted therapeutic proteins

Hydrogel Beads With Self-Regulating Microclimate pH Properties

Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor

GENETICALLY MODIFIED MESENCHYMAL STEM CELL EXPRESSING KLOTHO

ADENO-ASSOCIATED VIRUS MEDIATED GENE TRANSFER TO THE CENTRAL NERVOUS SYSTEM

Process for production and purification of recombinant lysosomal alpha-mannosidase

Methods and gene therapy constructs for treating GM2 gangliosidoses

METHODS AND COMPOSITIONS FOR TREATMENT OF FORBES-CORI DISEASE

Technology for the Preparation of Microparticles

Use of P97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes

Method for improving feed digestibility in bovine animals

COMPOSITION AND METHOD FOR PROMOTING REDUCTION OF HEAT STRESS IN ANIMALS

Methods, compositions, and molecular targets that exploit synergies and symbioses in the termite gut

Method of producing collagen from hydrolyzed egg membrane

Methods and compositions for improved cognition

Cleavable Lipids

Polypeptides Having N-Acetyl Glucosamine Oxidase Activity

Enzyme formulation for reducing salicylate and other intolerance

Adeno-associated virus vectors encoding modified G6PC and uses thereof

Collagenous tissue repair device

α-galactosidase A and 1-deoxygalactonojirimycin co-formulation

HUMAN ALPHA-GALACTOSIDASE VARIANTS

COMPOSITIONS AND METHODS FOR PROTECTING AGAINST AIRBORNE PATHOGENS AND IRRITANTS

Subcutaneously administered anti-IL-6 receptor antibody for treatment of juvenile idiopathic arthritis

Nucleic acids encoding targeted therapeutic lysosomal enzyme fusion proteins

Class of therapeutic protein based molecules

PROTEASE COMPOSITIONS FOR USE IN MODIFYING SEMEN

Escorted and functionalized guides for CRISPR-Cas systems

TREATMENT OF INFLAMMATORY CONDITIONS BY MODULATION OF HYALURONAN AND HYALURONIDASE ACTIVITY

Materials and Methods Useful For Treating Glioblastoma

Formulations comprising recombinant acid alpha-glucosidase

COMPOSITIONS FOR IMPROVEMENT OF BRAIN FUNCTION

Spray dry method for encapsulation of biological moieties and chemicals in polymers cross-linked by multivalent ions for controlled release applications

Sialylated glycoprotein compositions and uses thereof

Methods for coupling targeting peptides onto recombinant lysosomal enzymes for improved treatments of lysosomal storage diseases

Injectable, Non-Aqueous Suspension with High Concentration of Therapeutic Agent

Microparticle Formulations for Delivery to the Lower and Central Respiratory Tract and Methods of Manufacture

Compositions and methods to prevent and treat biofilms

ANTIMICROBIAL AGENTS

bacteriophage lysins for detection and treatment of gram positive bacteria

Composition for preventing or alleviating periodontal diseases, containing, as active ingredient, mangosteen extract or α- or γ-mangosteen

Combination therapy with an anti-hyaluronan agent and therapeutic agent

COMBINED THERAPEUTIC USE OF ANTIBODIES AND ENDOGLYCOSIDASES

GENERATION OF MANNOSE-6-PHOSPHATE CONTAINING RECOMBINANT ALPHA-N-ACETYL GLUCOSAMINIDASE

Treatment of ophthalmic conditions

Compositions for the Restoration of a Fecal Microbiota and Methods for Making and Using Them

COATED PARTICLES FOR DRUG DELIVERY

STABILIZER FOR HYALURONIDASE AND LIQUID FORMULATION COMPRISING HYALURONIDASE

APPLICATION OF POROUS MATERIALS FOR BACTERIAL QUORUM SENSING INHIBITION/DISRUPTION

PHARMACEUTICAL PREPARATIONS FOR ATTENTION DEFICIT DISORDER, ATTENTION DEFICIT HYPERACTIVITY DISORDER AND OTHER ASSOCIATED DISORDERS

Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof

Lysosomal targeting and uses thereof

COMPOSITIONS AND METHODS FOR PROTECTING AGAINST AIRBORNE PATHOGENS AND IRRITANTS

Selective recovery

Lysin agent and method of use for diagnostic testing

Ionizable cationic lipids

Lipid nanoparticle compositions and methods for MRNA delivery

POROUS NANOPARTICLE-SUPPORTED LIPID BILAYERS (PROTOCELLS) FOR TARGETED DELIVERY INCLUDING TRANSDERMAL DELIVERY OF CARGO AND METHODS THEREOF

Protein/oligonucleotide core-shell nanoparticle therapeutics

Mannose-6-phosphate bearing peptides fused to lysosomal enzymes

Hyaline cartilage shaping

CONTROLLED-RELEASE AND STRATIFIED CYCLODEXTRIN INCLUSION COMPLEX VEHICLES

Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor

Methods of treating Mucopolysaccharidosis IIIB (MPSIIIB)

RECOMBINANT HUMAN NAGLU PROTEIN AND USES THEREOF

Treatment of alpha-galactosidase a deficiency

Soluble bacterial and fungal proteins and methods and uses thereof in inhibiting and dispersing biofilm

Capped and uncapped RNA molecules and block copolymers for intracellular delivery of RNA

Alpha-galactosidase A and 1-deoxygalactonojirimycin co-formulation for the treatment of fabry disease

Process for encapsulating soluble biologics, therapeutics, and imaging agents

Phosphoserine containing compositions for immune tolerance induction

Microneedle device having a peptide therapeutic agent and an amino acid and methods of making and using the same

Methods and compositions for the prevention and treatment of influenza

METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROLOGIC DISEASE

Use of hyaluronidase for treatment of muscle stiffness

Lymphangiogenesis inhibitors for cancer and for graft survival

COMPOSITIONS AND COMBINATIONS FOR USE AS FOOD SUPPLEMENTS FOR ANIMALS

Method of treatment of schizophreniform disorder

Augmented Acid Alpha-Glucosidase For The Treatment Of Pompe Disease

PAENIBACILLUS LARVAE TREATMENT WITH PHAGE LYSIN FOR AMERICAN FOULBROOD DISEASE

Delivery of therapeutic compounds to the brain and other tissues

LYMPHOCYTE MEDIATED DELIVERY OF PROTEINS

Treatment of lysosomal storage diseases

Activated polyoxazolines and conjugates and compositions comprising the same

Method of reducing biofilms

Targeting peptides for directing adeno-associated viruses (AAVs)

Enzyme formulation for reducing salicylate intolerance

METHOD FOR TREATING PERVASIVE DEVELOPMENT DISORDERS

Variant, recombinant beta-glucocerebrosidase proteins with increased stability and increased retained catalytic activity

ENZYMES FOR REDUCED IMMUNOLOGICAL STRESS

Methods, Compounds and Compositions for Treatment of Influenza and Parainfluenza Patients

Compositions and kits for enzymatic debridement and methods of using the same

Antimicrobial preparations, methods for preparing the same and uses thereof to combat microorganisms

Peptide-mediated non-covalent delivery of active agents across the blood-brain barrier

PHAGE-DERIVED COMPOSITIONS FOR IMPROVED MYCOBACTERIAL THERAPY

Methods and compositions for treatment of glycogen storage diseases and glycogen metabolism disorders

GLUCANASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM

Acinetobacter lysins

METHOD FOR PREPARING INDUCED PLURIPOTENT STEM CELLS

Use of Hydrolytic and Oxidative Enzymes to Dissolve Biofilm in Ears

Therapeutic charge engineered variants of lysozyme and methods for using same to treat infections

BIOFILM PREVENTION, DISRUPTION AND TREATMENT WITH BACTERIOPHAGE LYSIN

Subcutaneous Formulations of Anti-CD38 Antibodies and Their Uses

Subcutaneous formulations of anti-CD38 antibodies and their uses

TREATMENT OF MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS

Medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity

PHARMACEUTICAL COMPOSITION AGAINST CHRONIC BACTERIAL INFECTIONS

Extracellular hyaluronidase from

SPINAL CATHETER HAVING MULTIPLE OBSTRUCTION-CLEARING FEATURES

Adenoassociated virus vectors for the treatment of lysosomal storage disorders

ORALLY ADMINISTERED PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME, COMPRISING AN INTESTINAL MOTILITY MODIFIER, AN AGENT THAT PREVENTS GAS RETENTION, AND DIGESTIVE ENZYMES, AND PREPARATION METHOD THEREOF

Protein hydrolysates as agents to treat symptoms of addiction

Combination of growth factors, cytokines, antibacterial/antiviral factors, stem cell stimulating factors, complement proteins C3A/C4A, immunoglobulins and chemotactic factors

Technology for the Preparation of Microparticles

Liquid triblock copolymer

Compositions and methods for delivering agents to the central nervous system

Stable liquid lactase compositions

High concentration alpha-glucosidase compositions for the treatment of Pompe disease

METHODS OF PERMITTING A SUBJECT TO RECEIVE MULTIPLE DOSES OF RECOMBINANT ADENO-ASSOCIATED VIRUS

NOROVIRUS DEACTIVATOR AND METHOD FOR PRODUCING SAME, METHOD FOR DEACTIVATING NOROVIRUS, METHOD FOR PRODUCING LYSOZYME COMPONENT FOR NOROVIRUS DEACTIVATION USE, PROPHYLACTIC OR THERAPEUTIC AGENT FOR NOROVIRUS INFECTION, AND EXTERNAL PREPARATION FOR SKIN FOR NOROVIRUS DEACTIVATION PURPOSES

Progranulin (PGRN) and its derivatives for diagnosis and treatment of lysosomal storage diseases

Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38

TARGETING OF GLYCOPROTEIN THERAPEUTICS

CNS delivery of therapeutic agents

ANIMAL TISSUE COLONIZATION AND TREATMENT OF INFECTION

Method and carrier complexes for delivering molecules to cells

Compositions comprising spores and whey

Bioerodible silicon-based devices for delivery of therapeutic agents

OLIGOSACCHARIDES COMPRISING AN AMINOOXY GROUP AND CONJUGATES THEREOF

Polypeptide having xylanase activity

Anti-CD38 antibodies for treatment of light chain amyloidosis and other CD38-positive hematological malignancies

Lysosomal Targeting Peptides and Uses Thereof

A Method for Improving Maize Digestibility in Bovine Animals