ClassID:

21036

A61K38/4846 - CPC Classification

Classification description:

Medicinal preparations containing peptides; Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof; Enzymes; Proenzymes; Derivatives thereof; Hydrolases (3) acting on peptide bonds (3.4); Serine endopeptidases (3.4.21) Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)

Recent Application in this class:
#1
20260130974
2026-05-14

FACTOR IX VARIANT POLYPEPTIDES FOR ADMINISTRATION TO SOFT TISSUE

#2
20260077061
2026-03-19

COMPOSITIONS AND METHODS FOR IN VIVO NUCLEASE-MEDIATED GENE TARGETING FOR THE TREATMENT OF GENETIC DISORDERS IN ADULT PATIENTS

#3
20250345404
2025-11-13

COMPOSITIONS AND METHODS FOR TREATING HEART FAILURE

#4
20250312488
2025-10-09

TARGETED INTEGRATION AT ALPHA-GLOBIN LOCUS IN HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS

#5
20250302927
2025-10-02

MODIFIED FACTOR XA POLYPEPTIDES AND METHODS OF USE

#6
20250276092
2025-09-04

METHODS AND COMPOSITIONS FOR RE-DOSING AAV USING ANTI-CD40 ANTAGONISTIC ANTIBODY TO SUPPRESS HOST ANTI-AAV ANTIBODY RESPONSE

#7
20250268990
2025-08-28

METHODS OF INDUCING IMMUNE TOLERANCE TO CLOTTING FACTORS

#8
20250255940
2025-08-14

COMPOSITIONS AND METHODS FOR EXPRESSING FACTOR IX

#9
20250242056
2025-07-31

METHODS AND COMPOSITIONS FOR USING PLASMA CELL DEPLETING AGENTS AND/OR B CELL DEPLETING AGENTS TO SUPPRESS HOST ANTI-AAV ANTIBODY RESPONSE AND ENABLE AAV TRANSDUCTION AND RE-DOSING

#10
20250222079
2025-07-10

FX ACTIVATION PROCESS AND ITS USE IN THE PREPARATION OF A FXA COMPOSITION

#11
20250195419
2025-06-19

CLOTTING FACTOR PREPARATIONS FOR DELIVERY INTO TISSUE OF THE INTESTINAL TRACT USING A SWALLOWABLE DRUG DELIVERY DEVICE

#12
20250186563
2025-06-12

UNIT DOSE FORMULATION OF ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME

#13
20250179462
2025-06-05

FACTOR IX POLYPEPTIDE MUTANT, ITS USES AND A METHOD FOR ITS PRODUCTION

#14
20250163399
2025-05-22

LYOPHILIZED FORMULATIONS FOR FACTOR XA ANTIDOTE

#15
20250152735
2025-05-15

Lipid Nanoparticle Compositions and Methods for mRNA Delivery

#16
20250145732
2025-05-08

TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF

#17
20250121066
2025-04-17

STABILIZED FACTOR IX FORMULATIONS CONTAINING TREHALOSE

#18
20250121042
2025-04-17

LYOPHILIZED FACTOR IX FORMULATIONS

#19
20250121041
2025-04-17

HEMOSTATIC COMPOSITION CONTAINING RECOMBINANT HUMAN CLOTTING FACTORS, AND METHOD OF PRODUCING

#20
20250121036
2025-04-17

METHODS OF TREATING HEMOPHILIC ARTHROPATHY USING CHIMERIC CLOTTING FACTORS

#21
20250108126
2025-04-03

Lipid Nanoparticle Compositions and Methods for mRNA Delivery

#22
20250090667
2025-03-20

DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS

#23
20250090666
2025-03-20

DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS

#24
20250074962
2025-03-06

MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PROTEINS AND PEPTIDES

#25
20250066415
2025-02-27

SYSTEMS FOR EXTRACTING PROTEINS FROM A BLOOD-BASED MATERIAL

#26
20250064937
2025-02-27

DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS

#27
20250057954
2025-02-20

DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS

#28
20250034081
2025-01-30

NOVEL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS

#29
20250018062
2025-01-16

MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF BIOLOGICS AND PROTEINS ASSOCIATED WITH HUMAN DISEASE

#30
20240409597
2024-12-12

MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF SECRETED PROTEINS

#31
20240390467
2024-11-28

PROHEMOSTATIC PROTEINS FOR THE TREATMENT OF BLEEDING

#32
20240350662
2024-10-24

SYSTEMS AND METHODS FOR NUCLEIC ACID EXPRESSION IN VIVO

#33
20240327476
2024-10-03

MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE

#34
20240293319
2024-09-05

Lipid Formulations for Delivery of Messenger RNA

#35
20240285806
2024-08-29

STABLE EXPRESSION OF AAV VECTORS IN JUVENILE SUBJECTS

#36
20240252645
2024-08-01

DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS

#37
20240239917
2024-07-18

COMBINATION THERAPY WITH COAGULATION FACTORS AND MULTISPECIFIC ANTIBODIES

#38
20240226003
2024-07-11

CLOTTING FACTOR PREPARATIONS FOR DELIVERY INTO TISSUE OF THE INTESTINAL TRACT USING A SWALLOWABLE DRUG DELIVERY DEVICE

#39
20240212861
2024-06-27

POPULATION PHARMACOKINETICS TOOLS AND USES THEREOF

#40
20240189446
2024-06-13

COMPOSITIONS AND METHODS FOR DELIVERY OF NUCLEIC ACIDS

#41
20240189401
2024-06-13

UNIT DOSE FORMULATION OF ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME

#42
20240131193
2024-04-25

MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS

#43
20240131126
2024-04-25

MODIFIED FACTOR IX, AND COMPOSITIONS, METHODS AND USES FOR GENE TRANSFER TO CELLS, ORGANS, AND TISSUES

#44
20240130965
2024-04-25

Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device

#45
20240123042
2024-04-18

METHODS AND COMPOSITIONS RELATED TO A TISSUE FACTOR-TARGETING IGG3 IMMUNOCONJUGATES

#46
20240082367
2024-03-14

ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME

#47
20240075151
2024-03-07

CONJUGATES OF TUMOR NECROSIS FACTOR INHIBITORS TO FUNCTIONALIZED POLYMERS

#48
20240075102
2024-03-07

Macrophage Stimulating 1 Receptor (MST1R) Variants And Uses Thereof

#49
20240066106
2024-02-29

HAEMORRHAGE INHIBITING COMPOSITIONS AND METHODS INVOLVING THE SAME

#50
20240066048
2024-02-29

SHORT-ACTING HEPARIN-BASED ANTICOAGULANT COMPOUNDS AND METHODS

#51
20240018503
2024-01-18

COAGULATION FACTOR IX WITH IMPROVED PHARMACOKINETICS

#52
20230416405
2023-12-28

Tissue factor pathway inhibitor antibodies and uses thereof

#53
20230338480
2023-10-26

A SYSTEM TO IMPROVE HAEMOSTATIC CONTROL

#54
20230338479
2023-10-26

HIGH-ACTIVITY BLOOD COAGULATION FACTOR XI MUTANT ALA570THR

#55
20230330262
2023-10-19

Lipid nanoparticle compositions and methods for mRNA delivery

#56
20230330185
2023-10-19

METHODS AND COMPOSITIONS FOR TRANSDUCING HEMATOPOIETIC STEM AND PROGENITOR CELLS IN VIVO

#57
20230310560
2023-10-05

FACTOR IX POLYPEPTIDE FORMULATIONS

#58
20230295596
2023-09-21

SHORT-ACTING FACTOR VII POLYPEPTIDES

#59
20230293728
2023-09-21

Liver-Specific Nucleic Acid Regulatory Elements and Methods and Use Thereof

#60
20230293723
2023-09-21

LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY

#61
20230285593
2023-09-14

Lipid nanoparticle compositions and methods for MRNA delivery

#62
20230285592
2023-09-14

Lipid nanoparticle compositions and methods for MRNA delivery

#63
20230285574
2023-09-14

CONJUGATES OF BIOLOGICALLY ACTIVE MOLECULES TO FUNCTIONALIZED POLYMERS

#64
20230166255
2023-06-01

Methods And Devices For Detection Of Anticoagulants In Plasma And Whole Blood

#65
20230158499
2023-05-25

Methods And Devices For Detection Of Anticoagulants In Plasma And Whole Blood

#66
20230158498
2023-05-25

Methods And Devices For Detection Of Anticoagulants In Plasma And Whole Blood

#67
20230142320
2023-05-11

Modified factor IX, and compositions, methods and uses for gene transfer to cells, organs, and tissues

#68
20230091082
2023-03-23

Chromatographic methods for purification of proteins from plasma

#69
20230067653
2023-03-02

ENGINEERED TARGET SPECIFIC NUCLEASES

#70
20230059111
2023-02-23

Translatable molecules and synthesis thereof

#71
20230056486
2023-02-23

METHODS OF TREATING NEUROLOGICAL DISORDERS

#72
20230022913
2023-01-26

Conjugates of tumor necrosis factor inhibitors to functionalized polymers

#73
20230022390
2023-01-26

Vectors for Liver-Directed Gene Therapy of Hemophilia and Methods and Use Thereof

#74
20230000957
2023-01-05

UNIT DOSE FORMULATION OF ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME

#75
20230000952
2023-01-05

THERAPEUTIC AGENTS COMPRISING ELASTIN-LIKE PEPTIDES

#76
20230000765
2023-01-05

Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device

#77
20220412996
2022-12-29

BLOOD FACTOR MONITORING ASSAY AND USES THEREOF

#78
20220402969
2022-12-22

Methods for Extracting Proteins from a Blood-Based Material

#79
20220378939
2022-12-01

Lipid nanoparticle compositions and methods for mRNA delivery

#80
20220362406
2022-11-17

LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY

#81
20220354792
2022-11-10

Lyophilized formulations for factor XA antidote

#82
20220347099
2022-11-03

Lipid formulations for delivery of messenger RNA

#83
20220331409
2022-10-20

FACTOR IX GENE THERAPY

#84
20220306696
2022-09-29

ISOLATED MODIFIED VP1 CAPSID PROTEIN OF AAV5

#85
20220288172
2022-09-15

Prohemostatic proteins for the treatment of bleeding

#86
20220243189
2022-08-04

PROCOAGULANT COMPOUNDS

#87
20220218639
2022-07-14

TUNEABLE DELIVERY OF NANOPARTICLE BOUND ACTIVE PLASMIN FOR THE TREATMENT OF THROMBOSIS

#88
20220213501
2022-07-07

Method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby

#89
20220193129
2022-06-23

B CELLS FOR IN VIVO DELIVERY OF THERAPEUTIC AGENTS AND DOSAGES THEREOF

#90
20220170005
2022-06-02

Long-acting coagulation factors and methods of producing same

#91
20220154161
2022-05-19

FACTOR IX VARIANTS AND USES THEREOF IN THERAPY

#92
20220152197
2022-05-19

COMBINATION OF FACTOR VII AND AN ANTI-FACTOR IX/X BISPECIFIC ANTIBODY

#93
20220135959
2022-05-05

CHIMERIC CLOTTING FACTORS

#94
20220125894
2022-04-28

METHODS FOR TREATING INTRACRANIAL HEMORRHAGE AND ASSESSING EFFICACY

#95
20220119550
2022-04-21

COMBINATION THERAPY WITH COAGULATION FACTORS AND MULTISPECIFIC ANTIBODIES

#96
20220118063
2022-04-21

METHODS AND COMPOSITIONS RELATED TO IMPROVED FACTOR VIII LONG HALF-LIFE COAGULATION COMPLEXES

#97
20220111072
2022-04-14

Lipid nanoparticle compositions and methods for mRNA delivery

#98
20220111071
2022-04-14

LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY

#99
20220111070
2022-04-14

Lipid nanoparticle compositions and methods for MRNA delivery

#100
20220105201
2022-04-07

Lipid nanoparticle compositions and methods for mRNA delivery

#101
20220090042
2022-03-24

FACTOR IX POLYPEPTIDE MUTANT, ITS USES AND A METHOD FOR ITS PRODUCTION

#102
20220073894
2022-03-10

METHODS AND COMPOSITIONS FOR MODIFIED FACTOR IX PROTEINS

#103
20220054604
2022-02-24

Stabilised Compositions of Factor VII Polypeptides

#104
20220040330
2022-02-10

Lipid nanoparticle compositions and methods for mRNA delivery

#105
20220031856
2022-02-03

Conjugates of tumor necrosis factor inhibitors to functionalized polymers

#106
20220025401
2022-01-27

Method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby

#107
20220025399
2022-01-27

Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor

#108
20220016264
2022-01-20

AAV VIRIONS WITH DECREASED IMMUNOREACTIVITY AND USES THEREFOR

#109
20220002702
2022-01-06

FACTOR IX POLYPEPTIDE MUTANT, ITS USES AND A METHOD FOR ITS PRODUCTION

#110
20220000990
2022-01-06

LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME

#111
20210395714
2021-12-23

MODIFIED FACTOR IX POLYPEPTIDES

#112
20210386857
2021-12-16

Delivery and formulation of engineered nucleic acids

#113
20210379163
2021-12-09

INHIBITION OF TISSUE FACTOR PATHWAY INHIBITOR WITH FACTOR XA DERIVATIVES

#114
20210369868
2021-12-02

Optimized Liver-Specific Expression Systems for FVIII and FIX

#115
20210369866
2021-12-02

Biodegradable lipids for delivery of nucleic acids

#116
20210355231
2021-11-18

Treatment and prevention of hemophilic arthropathy with an antibody against endothelial cell protein C receptor (EPCR)

#117
20210348190
2021-11-11

ADENO-ASSOCIATED VIRUS (AAV) SEROTYPE 8 SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR

#118
20210348150
2021-11-11

CLOTTING FACTOR-FC CHIMERIC PROTEINS TO TREAT HEMOPHILIA

#119
20210340515
2021-11-04

ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME

#120
20210330763
2021-10-28

Modified factor IX, and compositions, methods and uses for gene transfer to cells, organs, and tissues

#121
20210317475
2021-10-14

RECOMBINANT AAV VECTORS USEFUL FOR REDUCING IMMUNITY AGAINST TRANSGENE PRODUCTS

#122
20210300755
2021-09-30

Lipid nanoparticle compositions and methods for mRNA delivery

#123
20210299278
2021-09-30

MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF BIOLOGICS AND PROTEINS ASSOCIATED WITH HUMAN DISEASE

#124
20210290738
2021-09-23

FX activation process and its use in the preparation of a FXa composition

#125
20210285012
2021-09-16

METHOD OF DETECTING AND/OR IDENTIFYING ADENO-ASSOCIATED VIRUS (AAV) SEQUENCES AND ISOLATING NOVEL SEQUENCES IDENTIFIED THEREBY

#126
20210284986
2021-09-16

LYOPHILIZED FORMULATIONS FOR FACTOR XA ANTIDOTE

#127
20210283266
2021-09-16

Conjugates of biologically active molecules to functionalized polymers

#128
20210275668
2021-09-09

COMBINATION OF FACTOR VII AND AN ANTI-FACTOR IX/X BISPECIFIC ANTIBODY

#129
20210261608
2021-08-26

Methods for extracting proteins from a blood-based material

#130
20210238573
2021-08-05

FACTOR IX POLYPEPTIDE MUTANT, ITS USES AND A METHOD FOR ITS PRODUCTION

#131
20210236649
2021-08-05

METHODS FOR TREATING DISORDERS ASSOCIATED WITH ANGIOGENESIS AND NEOVASCULARIZATION

#132
20210230570
2021-07-29

MODIFIED FACTOR IX POLYPEPTIDES AND USES THEREOF

#133
20210214704
2021-07-15

FACTOR IX POLYPEPTIDE MUTANT, ITS USES AND A METHOD FOR ITS PRODUCTION

#134
20210205471
2021-07-08

CONCEPTS FOR THE TREATMENT OF GENETIC DISORDERS WITH HIGH-CAPACITY PLAL-GENERATED GOLD NANOPARTICLES

#135
20210187083
2021-06-24

Modified factor VII polypeptides for subcutaneous administration and on-demand treatment

#136
20210177983
2021-06-17

SINGLE CHAIN Fc FUSION PROTEINS

#137
20210177976
2021-06-17

STABILIZED FACTOR IX FORMULATIONS CONTAINING TREHALOSE

#138
20210154276
2021-05-27

Methods of treating neurological disorders

#139
20210146054
2021-05-20

Medical Delivery Devices With Inhibited Oxygen Permeation

#140
20210145889
2021-05-20

METHODS, COMPOSITIONS, AND IMPLANTABLE ELEMENTS COMPRISING STEM CELLS

#141
20210137967
2021-05-13

Short-acting heparin-based anticoagulant compounds and methods

#142
20210128700
2021-05-06

VIRAL VECTORS ENCODING RECOMBINANT FIX WITH INCREASED EXPRESSION FOR GENE THERAPY OF HEMOPHILIA B

#143
20210115101
2021-04-22

MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE

#144
20210107861
2021-04-15

Lipids and lipid nanoparticle formulations for delivery of nucleic acids

#145
20210106658
2021-04-15

COMPOSITIONS COMPRISING HETEROGENEOUS POPULATIONS OF RECOMBINANT HUMAN CLOTTING FACTOR XA PROTEINS

#146
20210101998
2021-04-08

Tissue factor pathway inhibitor antibodies and uses thereof

#147
20210085762
2021-03-25

UNIT DOSE FORMULATION OF ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME

#148
20210077634
2021-03-18

IN VIVO PRODUCTION OF PROTEINS

#149
20210069307
2021-03-11

Lyophilized factor IX formulations

#150
20210069306
2021-03-11

MODIFIED FACTOR VII POLYPEPTIDES FOR SUBCUTANEOUS ADMINISTRATION AND ON-DEMAND TREATMENT

#151
20210062143
2021-03-04

Method of targeting exosomes

#152
20210060177
2021-03-04

Lipid nanoparticle compositions and methods for mRNA delivery

#153
20210060175
2021-03-04

METHODS OF IMMUNOSTIMULATION WITH COMPLEXES OF RNA AND CATIONIC CARRIERS

#154
20210046157
2021-02-18

Macrophage stimulating 1 receptor (MST1R) variants and uses thereof

#155
20210023186
2021-01-28

POLYMER FACTOR IX MOIETY CONJUGATES

#156
20210023185
2021-01-28

Factor IX polypeptides and methods of use thereof

#157
20210008179
2021-01-14

Modified factor IX, and compositions, methods and uses for gene transfer to cells, organs, and tissues

#158
20210008178
2021-01-14

FACTOR IX POLYPEPTIDES AND METHODS OF USE THEREOF

#159
20210002624
2021-01-07

Short-acting Factor VII polypeptides

#160
20210000930
2021-01-07

COMPOSITIONS AND METHODS FOR COUNTERACTING FACTOR XA INHIBITION

#161
20200362328
2020-11-19

METHODS AND COMPOSITIONS FOR MODIFIED FACTOR IX PROTEINS

#162
20200354423
2020-11-12

MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF SECRETED PROTEINS

#163
20200345856
2020-11-05

Conjugates of tumor necrosis factor inhibitors to functionalized polymers

#164
20200338214
2020-10-29

Lipid nanoparticle compositions and methods for mRNA delivery

#165
20200338199
2020-10-29

SODIUM CHLORIDE SOLUTION FOR DRUG RECONSTITUTION OR DILUTION

#166
20200299668
2020-09-24

Lyophilized formulations for factor Xa antidote

#167
20200299667
2020-09-24

LYOPHILIZED FORMULATIONS FOR FACTOR XA ANTIDOTE

#168
20200289628
2020-09-17

Compositions and methods for expressing factor IX

#169
20200289624
2020-09-17

METHODS AND COMPOSITIONS RELATED TO LONG HALF-LIFE COAGULATION COMPLEXES

#170
20200283799
2020-09-10

ADENO-ASSOCIATED VIRUS (AAV) SEROTYPE 8 SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR

#171
20200282022
2020-09-10

Therapeutic agents comprising a BMP-9 peptide and eleastin-like peptides

#172
20200276280
2020-09-03

Antidotes for factor Xa inhibitors and methods of using the same

#173
20200261554
2020-08-20

Factor IX polypeptide formulations

#174
20200261386
2020-08-20

Tuneable delivery of nanoparticle bound active plasmin for the treatment of thrombosis

#175
20200255816
2020-08-13

Long-acting coagulation factors and methods of producing same

#176
20200254072
2020-08-13

Stabilised Solid Compositions of Factor VII Polypeptides

#177
20200247861
2020-08-06

MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PROTEINS AND PEPTIDES

#178
20200231958
2020-07-23

FACTOR IX POLYPEPTIDE MUTANT, ITS USES AND A METHOD FOR ITS PRODUCTION

#179
20200222558
2020-07-16

Biodegradable lipids for delivery of nucleic acids

#180
20200222546
2020-07-16

Conjugates of biologically active molecules to functionalized polymers

#181
20200222318
2020-07-16

Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device

#182
20200199564
2020-06-25

FACTOR IX POLYPEPTIDE MUTANT, ITS USES AND A METHOD FOR ITS PRODUCTION

#183
20200190498
2020-06-18

FACTOR IX POLYPEPTIDE MUTANT, ITS USES AND A METHOD FOR ITS PRODUCTION

#184
20200190214
2020-06-18

Tissue factor pathway inhibitor antibodies and uses thereof

#185
20200172892
2020-06-04

Factor IX variants with clotting activity in absence of their cofactor and/or with increased F.IX clotting activity and their use for treating bleeding disorders

#186
20200155706
2020-05-21

Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins

#187
20200140840
2020-05-07

FACTOR IX VARIANTS AND METHODS OF USE THEREFOR

#188
20200138952
2020-05-07

SODIUM CHLORIDE SOLUTION FOR DRUG RECONSTITUTION OR DILUTION

#189
20200138917
2020-05-07

Prohemostatic proteins for the treatment of bleeding

#190
20200138916
2020-05-07

Prohemostatic proteins for the treatment of bleeding

#191
20200131534
2020-04-30

Method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby

#192
20200129598
2020-04-30

MODIFIED FACTOR IX, AND COMPOSITIONS, METHODS AND USES FOR GENE TRANSFER TO CELLS, ORGANS, AND TISSUES

#193
20200129597
2020-04-30

MODULATION OF FACTOR Xa INHIBITOR-MEDIATED BLOOD LOSS BY PARTIAL AND TRANSIENT ADMINISTRATION OF ANTIDOTE

#194
20200109390
2020-04-09

COAGULATION FACTOR IX WITH IMPROVED PHARMACOKINETICS

#195
20200102577
2020-04-02

DELIVERY METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED GENOME ENGINEERING

#196
20200095565
2020-03-26

METHODS AND COMPOSITIONS FOR MODIFIED FACTOR IX PROTEINS

#197
20200093901
2020-03-26

SUBCUTANEOUS ADMINISTRATION OF LONG-ACTING FACTOR IX IN HUMANS

#198
20200087684
2020-03-19

Method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby

#199
20200085973
2020-03-19

LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY

#200
20200085922
2020-03-19

Methods and compositions related to a tissue factor-targeting IGG3 immunoconjugates

#201
20200085915
2020-03-19

Methods of inducing immune tolerance to clotting factors

#202
20200080109
2020-03-12

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Lipid formulations for delivery of messenger RNA

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STABLE EXPRESSION OF AAV VECTORS IN JUVENILE SUBJECTS

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Silicone free drug delivery devices

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Stabilised Compositions of Factor VII Polypeptides

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Methods of treating hemophilic arthropathy using chimeric clotting factors

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Cyclodextrins as procoagulants

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POPULATION PHARMACOKINETICS TOOLS AND USES THEREOF

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B-CELL ENGINEERING

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Blood coagulation factor replacement product for use in the treatment or prophylaxis of bleedings

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Modified polynucleotides for the production of secreted proteins

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In vivo production of proteins

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AAV virions with decreased immunoreactivity and uses therefor

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Blood coagulation protein conjugates

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Procoagulant compounds

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Antidotes for factor Xa inhibitors and methods of using the same

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SINGLE-DOSE ADMINISTRATION OF FACTOR VIIa

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Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor

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POLYMERS FOR DELIVERY OF FACTOR VIII AND/OR FACTOR IX

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Lipids and lipid nanoparticle formulations for delivery of nucleic acids

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METHODS AND COMPOSITIONS FOR MODIFIED FACTOR IX PROTEINS

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Engineered target specific nucleases

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MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS

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Vectors for liver-directed gene therapy of hemophilia and methods and use thereof

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COMPOSITIONS AND METHODS FOR TREATING INTRACEREBRAL HEMORRHAGE

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Compositions of human prothrombin and activated factor X for improving hemostasis in the treatment of bleeding disorders

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Chimeric clotting factors

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Extracellular histones as biomarkers for prognosis and molecular targets for therapy

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Lipid nanoparticle compositions and methods for mRNA delivery

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Factor IX polypeptides and methods of use thereof

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Factor IX polypeptides and methods of use thereof

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Lipid nanoparticle compositions and methods for mRNA delivery

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METHODS OF TREATING A SUBJECT HAVING GLYCOGEN STORAGE DISEASE WITH mRNA ENCODING GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT (G6PC)

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METHODS OF TREATING A SUBJECT HAVING PROPIONIC ACIDEMIA WITH mRNA ENCODING PROPIONYL-COA CARBOXYLASE, SUBUNIT ALPHA AND/OR BETA (PCCA AND/OR PCCB)

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METHODS OF TREATING A SUBJECT HAVING CITRULLINEMIA WITH mRNA ENCODING ARGININOSUCCINATE SYNTHASE (ASS)

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METHODS OF TREATING A SUBJECT HAVING FRIEDREICH'S ATAXIA WITH mRNA ENCODING FRATAXIN

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METHODS OF TREATING A SUBJECT HAVING GLYCOGEN STORAGE DISEASE II WITH mRNA ENCODING ACID GLUCOSIDASE ALPHA (GAA)

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METHODS OF TREATING A SUBJECT WITH mRNA ENCODING COAGULATION FACTOR VIII (F8)

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METHODS OF TREATING PHENYLKETONURIA WITH MRNA ENCODING PHENYLALANINE HYDROXYLASE (PAH)

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STABILIZED FACTOR IX FORMULATIONS CONTAINING TREHALOSE

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MODIFIED BLOOD FACTORS COMPRISING A LOW DEGREE OF WATER SOLUBLE POLYMER

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Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device

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Conjugates of biologically active molecules to functionalized polymers

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Methods And Devices For Detection Of Anticoagulants In Plasma And Whole Blood

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Stabilised Solid Compositions of Factor VII Polypeptides

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ANTIBODY FORMULATIONS CONTAINING AMINO ACIDS

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Single dose administration of factor VIIa

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Methods of increasing nutrient absorption in the intestine using therapeutic agents comprising GLP-2 and elastin-like peptides

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Systems and Methods for Nucleic Acid Expression In Vivo

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Coagulation factor-targeting to TREM-like transcript 1 (TLT-1) on activated platelets

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Factor IX gene therapy

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Delivery and formulation of engineered nucleic acids

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Pharmaceutical formulations of PEGylated liposomes and blood coagulation factors

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Methods for extracting proteins from a blood-based material

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Liver-specific nucleic acid regulatory elements and methods and use thereof

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Systems and methods for nucleic acid expression in vivo

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LYOPHILIZED FORMULATIONS FOR FACTOR XA ANTIDOTE

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Long-acting coagulation factors and methods of producing same

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STABILIZING AGENT FOR PHARMACEUTICAL PROTEINS

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Method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby

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Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor

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SINGLE-DOSE ADMINISTRATION OF FACTOR VIIa

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Conjugates of tumor necrosis factor inhibitors to functionalized polymers

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METHODS, COMPOSITIONS AND KITS FOR REDUCING TISSUE ADHESIONS

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Lipid formulations for delivery of messenger RNA

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Blood factor monitoring assay and uses thereof

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MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF COSMETIC PROTEINS AND PEPTIDES

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Long-acting coagulation factors and methods of producing same

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Compositions and methods for counteracting Factor Xa inhibition

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Viral vectors encoding recombinant fix with increased expression for gene therapy of hemophilia B

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INHIBITION OF TISSUE FACTOR PATHWAY INHIBITOR WITH FACTOR XA DERIVATIVES

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Translatable molecules and synthesis thereof

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LYOPHILIZED FORMULATIONS FOR FACTOR XA ANTIDOTE

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Modified Polynucleotides for the production of biologics and proteins associated with human disease

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COMPLEXES OF RNA AND CATIONIC PEPTIDES FOR TRANSFECTION AND FOR IMMUNOSTIMULATION

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Single chain Fc fusion proteins

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AAV VIRIONS WITH DECREASED IMMUNOREACTIVITY AND USES THEREFOR

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Biodegradable lipids for delivery of nucleic acids

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Biodegradable lipids for delivery of nucleic acids

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Biodegradable lipids for delivery of nucleic acids

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Biodegradable lipids for delivery of nucleic acids

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Factor IX polypeptide mutant, its uses and method for its production

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Compositions and Methods for Modulating Hemostasis

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Factor IX variants with clotting activity in absence of their cofactor and/or with increased F.IX clotting activity and their use for treating bleeding disorders

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Monoclonal antibodies against antithrombin beta

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Combination Therapy with Coagulation Factors and Multispecific Antibodies

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CLOTTING FACTOR-FC CHIMERIC PROTEINS TO TREAT HEMOPHILIA

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Unit dose formulation of antidotes for factor Xa inhibitors and methods of using the same

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Factor IX Polypeptides and Methods of Use Thereof

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Factor IX polypeptides and methods of use thereof