24193 ⎘
Electrotherapy; Circuits therefor; Applying electric currents by contact electrodes alternating or intermittent currents for stimulation; Implantable neurostimulators for stimulating central or peripheral nerve system; Control systems specified by the stimulation parameters Timing, e.g. stimulation onset
Adaptive Deep Brain Stimulation Based on Neural Signals with Dynamics
#2DEVICES AND METHODS FOR CONTROLLING TREMOR
#3WEARABLE DEVICES FOR VIBRATORY STIMULATION TO REDUCE TREMOR
#4TREMOR TREATMENT SYSTEMS USING VIBRATORY STIMULATION
#5PREDEFINED SCHEDULING PATTERNS FOR SIMPLIFIED IMPLEMENTATION
#6WIRELESS NEUROMODULATION SYSTEMS
#7SYSTEMS AND METHODS FOR RESTORING MUSCLE FUNCTION TO THE LUMBAR SPINE
#8NEUROMODULATION PROGRAMMING USING COMBINED MODULATION CONFIGURATIONS
#9WIRELESS NEUROSTIMULATORS
#10System and Method for Adaptive Neural Stimulation
#11Synchronized Evoked Response Measurements in a Bilateral Hearing System
#12Prescribed Neuromodulation Dose Delivery
#13USER INTERFACE FOR TITRATION ASSIST
#14SYSTEM AND METHOD FOR TREATING VARIOUS NEUROLOGICAL DISORDERS USING SYNCHRONIZED NERVE ACTIVATION
#15STIMULATION SUSPENSION IN RESPONSE TO PATIENT DISCOMFORT OR STATE
#16METHOD AND SYSTEM FOR ADJUSTING A NEUROSTIMULATION THERAPY
#17SEPARABLE HOUSING FOR TREMOR REDUCTION SYSTEM
#18TREMOR REDUCTION USING MACHINE LEARNING ALGORITHMS
#19TREMOR REDUCTION USING CLOUD COMPUTING
#20TAILORED NERVE STIMULATION FOR TREMOR
#21EXTREMELY LOW DUTY-CYCLE ACTIVATION OF THE CHOLINERGIC ANTI-INFLAMMATORY PATHWAY TO TREAT CHRONIC INFLAMMATION
#22NERVE REGENERATION SYSTEM AND METHOD
#23Paresthesia-Free Spinal Cord Stimulation Occurring at Lower Frequencies Involving Perception Threshold Determinations
#24NEUROMODULATION OF TWO OR MORE NEURONAL TARGETS IN TREATMENT OF A MEDICAL CONDITION
#25IMPLANTABLE AND NON-INVASIVE STIMULATORS FOR GASTROINTESTINAL THERAPEUTICS
#26METHOD AND APPARATUS FOR ECAP-BASED DYNAMIC STIMULATION PROGRAMMING
#27SYSTEMS AND METHODS FOR SCHEDULED NEUROMODULATION THERAPY
#28SYSTEMS AND METHODS FOR RESTORING MUSCLE FUNCTION TO THE LUMBAR SPINE
#29METHOD AND APPARATUS FOR APPLICATION OF A NEURAL STIMULUS
#30METHODS AND SYSTEMS FOR DEEP BRAIN STIMULATION OF THE NUCLEUS BASALIS OF MEYNERT
#31MULTI-MODAL SYNCHRONIZATION THERAPY
#32Systems and Methods for Randomized Coordinated Reset Deep Brain Stimulation
#33BATTERYLESS IMPLANTABLE MICROSTIMULATORS
#34DEVICES AND METHODS FOR CONTROLLING TREMOR
#35NEUROREHABILITATION SYSTEM AND METHOD OF NEUROREHABILITATION COMPRISING NEURALLY CONTROLLED STIMULATION
#36ELECTRICAL APPARATUS AND METHODS FOR AN EYE
#37STIMULATION CYCLING ADJUSTMENTS BASED ON USER INPUT
#38Systems and methods for restoring muscle function to the lumbar spine
#39IMPLANT SYSTEM AND METHOD
#40NEUROSTIMULATION USING ONE OR MORE CYCLING PARAMETERS FOR A NON-PARESTHESIA STIMULATION PATTERN
#41SYSTEMS AND METHODS FOR ENHANCING FUNCTION OF SPINE STABILIZATION MUSCLES ASSOCIATED WITH A SPINE SURGERY INTERVENTION
#42An Automated Process for Optimizing Spinal Cord Stimulation
#43SYSTEM AND PROCESS FOR CLOSED-LOOP DEEP BRAIN STIMULATION
#44HEARING PROSTHESIS
#45METHOD AND SYSTEM FOR BIVENTRICULAR OR LEFT VENTRICULAR PACING
#46NEUROSTIMULATION TITRATION UTILIZING T-WAVE ALTERNANS
#47BIDIRECTIONAL SPIKE-TIMING-DEPENDENT BRAIN NETWORK GAIN CONTROL
#48METHODS FOR TREATING TINNITUS WITH VNS
#49NERVE STIMULATION SYSTEM
#50STOCHASTIC STIMULATION SCHEDULING
#51CONTROLLED NEUROMODULATION SYSTEMS AND METHODS OF USE
#52SYSTEMS AND METHODS FOR DETERMINING EFFECTS OF A TRIGGERING EVENT THAT OCCURS DURING USE OF A HEARING DEVICE
#53ADAPTIVE ELECTRICAL NEUROSTIMULATION TREATMENT TO REDUCE PAIN PERCEPTION
#54MULTIPLE TARGET STIMULATION THERAPY FOR SLEEP DISORDERED BREATHING
#55STIMULATION SUSPENSION IN RESPONSE TO PATIENT DISCOMFORT OR STATE
#56Batteryless implantable microstimulators
#57NEUROMODULATION AND OTHER THERAPIES TO TREAT A COMBINATION OF OBSTRUCTIVE SLEEP APNEA AND CENTRAL SLEEP APNEA
#58NEURAL STIMULATION DEVICE, NEURAL STIMULATION SYSTEM, AND CONTROL METHOD
#59SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS
#60Logging the execution of sub-programs within a stimulation program for an implantable stimulator device
#61USER INTERFACE FOR NEURAL SIGNAL AND BIOMARKER VISUALIZATION AND ASSESSMENT
#62Systems and Methods for Monitoring Neural Activity
#63TRIALING USING PHYSIOLOGICAL SENSED SIGNALS FOR MEDICAL DEVICE IMPLANTATION
#64Implantable and non-invasive stimulators for gastrointestinal therapeutics
#65Therapy Implemented Using Different Sub-Perception Neuromodulation Types
#66HIGH FREQUENCY ELECTROSTIMULATION TREATMENT FOR RESTLESS LEGS SYNDROME OR PERIODIC LIMB MOVEMENT DISORDER
#67Neurostimulation titration process via adaptive parametric modification
#68Neuromodulation apparatus, method and system
#69IMPLANTABLE PULSE GENERATOR FOR PROVIDING A NEUROSTIMULATION THERAPY BY BLENDING CURRENT AND VOLTAGE CONTROL FOR OUTPUT AND METHODS OF OPERATION
#70AUTOMATING BOLUS STIMULATION THERAPY FROM LEARNED USAGE
#71Prescribed Neuromodulation Dose Delivery
#72Nerve regeneration system and method
#73METHOD AND SYSTEM FOR ADJUSTING A NEUROSTIMULATION THERAPY
#74SYSTEM AND METHOD FOR TREATING VARIOUS NEUROLOGICAL DISORDERS USING SYNCHRONIZED NERVE ACTIVATION
#75TECHNIQUES FOR PLACING IMPLANTABLE ELECTRODES TO TREAT SLEEP APNEA, AND ASSOCIATED SYSTEMS
#76Systems and methods for restoring muscle function to the lumbar spine
#77Systems and methods for enhancing function of spine stabilization muscles associated with a spine surgery intervention
#78Medial Olivocochlear Reflex Sound Coding with Bandwidth Normalization
#79SYSTEM AND METHOD FOR CONTROLLING NEUROSTIMULATION ACCORDING TO USER ACTIVITY AND AUTOMATED RESCHEDULING OF STIMULATION PROGRAMS
#80METHOD AND APPARATUS FOR APPLICATION OF A NEURAL STIMULUS
#81Adaptive electrical neurostimulation treatment to reduce pain perception
#82System and Method for Adaptive Neural Stimulation
#83APPARATUS AND METHOD FOR REDUCING THE EFFECT OF LEAD MIGRATION DURING SPINAL CORD STIMULATION
#84Adaptive Deep Brain Stimulation Based on Neural Signals with Dynamics
#85Stimulation cycling adjustments based on user input
#86SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS
#87Hearing prosthesis
#88BLADDER EVENT DETECTION FOR DIAGNOSIS OF URINARY INCONTINENCE OR TREATMENT OF LOWER URINARY TRACT DYSFUNCTION
#89SYSTEMS AND METHODS FOR AIDING A USER IN BREATHING USING IMPLANTABLE DEVICES
#90Neuromodulation therapy with custom instruction set architecture for a stimulation engine system
#91Methods for treating tinnitus with VNS
#92WIRELESS NEUROSTIMULATORS
#93Systems And Methods Of Detecting And Treating Obstructive Sleep Apnea
#94STIMULATION PROGRAMMING AND CONTROL BASED ON PATIENT AMBULATORY VELOCITY
#95TECHNIQUES FOR PLACING IMPLANTABLE ELECTRODES TO TREAT SLEEP APNEA, AND ASSOCIATED SYSTEMS
#96Batteryless implantable microstimulators
#97Systems and methods for restoring muscle function to the lumbar spine and kits for implanting the same
#98USER AWARE MICROCURRENT THERAPY DEVICE
#99Systems and methods for restoring muscle function to the lumbar spine
#100ELECTROPHYSIOLOGICALLY GUIDED DEEP BRAIN STIMULATION SURGERY UNDER VARIOUS STATES OF MEDICATION AND AROUSAL
#101SYNC PULSE DETECTOR
#102METHOD AND APPARATUS FOR CHARGE BALANCING DURING DELIVERY OF ELECTRICAL STIMULATION
#103SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS
#104Method and system for biventricular or left ventricular pacing
#105Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods
#106HIGH DUTY CYCLE ELECTRICAL STIMULATION THERAPY
#107Methods and systems for deep brain stimulation of the nucleus basalis of Meynert
#108Methods and systems for deep brain stimulation of the nucleus basalis of Meynert
#109Systems and Methods for Deep Brain Stimulation Using Beta Burst Feedback
#110Systems and methods for enhancing function of spine stabilization muscles associated with a spine surgery intervention
#111Cuff electrode
#112Variable operating point neural electrostimulation such as to treat RLS
#113Neuromodulation apparatus, method and system
#114System and method for controlling neurostimulation according to user activity and automated rescheduling of stimulation programs
#115Method and apparatus for application of a neural stimulus
#116Implant system and method
#117High frequency electrostimulation treatment for restless legs syndrome or periodic limb movement disorder
#118Method and apparatus for application of a neural stimulus
#119Electrical apparatus and methods for an eye
#120Implantable and non-invasive stimulators for gastrointestinal therapeutics
#121IMPLANTABLE NEUROSTIMULATOR-IMPLEMENTED METHOD FOR MANAGING BRADYCARDIA THROUGH VAGUS NERVE STIMULATION
#122Nerve stimulation system
#123Bidirectional spike-timing-dependent brain network gain control
#124Control system for an implantable stimulating device for stimulating a vagus nerve
#125IMPLANTABLE NEUROSTIMULATION SYSTEM
#126Adaptive deep brain stimulation of the superolateral medial forebrain bundle
#127Method and apparatus for application of a neural stimulus
#128Method and apparatus for application of a neural stimulus
#129Logging the execution of sub-programs within a stimulation program for an implantable stimulator device
#130Method and apparatus for application of a neural stimulus
#131Method and apparatus for application of a neural stimulus
#132Wireless neurostimulators
#133Klotho modulation
#134Control policy settings for electrical stimulation therapy
#135Systems and methods for enhancing function of spine stabilization muscles associated with a spine surgery intervention
#136High duty cycle electrical stimulation therapy
#137Multi-modal synchronization therapy
#138Systems and methods for monitoring neural activity
#139SYSTEMS, METHODS AND DEVICES FOR PAIRED PLASTICITY
#140SYSTEMS FOR TREATING OBSTRUCTIVE SLEEP APNEA
#141ONSET-MITIGATING HIGH-FREQUENCY NERVE BLOCK
#142Variable operating point neural electrostimulation such as to treat RLS
#143System and method for gastric electrical stimulation using compound nerve action potential feedback
#144Adaptive electrical neurostimulation treatment to reduce pain perception
#145Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods
#146METHODS FOR PROVIDING OPTIMIZED NEUROSTIMULATION
#147STIMULATION SUSPENSION IN RESPONSE TO PATIENT DISCOMFORT OR STATE
#148Neurostimulation titration utilizing T-wave alternans
#149Methods and apparatus for adjusting neurostimulation intensity using evoked responses
#150Nerve regeneration method
#151Nerve regeneration system and method
#152Devices and methods for controlling tremor
#153Systems and methods of conveying a visual image to a person fitted with a visual prosthesis
#154Electrode arrangement for stimulating and recording electrical signals in biological matter, a neural probe, a micro-electrode array and a method for controlling an electrode arrangement
#155Systems and methods for restoring muscle function to the lumbar spine
#156SUBTHRESHOLD DIRECT CURRENT (DC) NERVE CONDUCTION BLOCK AFTER SUPRATHRESHOLD "PRIMING"
#157User interface for neural signal and biomarker visualization and assessment
#158METHODS AND SYSTEMS FOR GLUCOSE REGULATION
#159USER INTERFACE FOR TITRATION ASSIST
#160System and method for treating various neurological disorders using synchronized nerve activation
#161SYSTEMS AND METHODS FOR IMPROVED HIS BUNDLE AND BACKUP PACING TIMING
#162Method and apparatus for application of a neural stimulus
#163Electrical stimulator configuration with initial high-density stimulation
#164Artificial retina stimulator and apparatus with image jittering function
#165Method and system for adjusting a neurostimulation therapy
#166SYSTEMS AND METHODS FOR AVOIDING NEURAL STIMULATION HABITUATION
#167Nerve stimulation device for current steering
#168Neurostimulation using one or more cycling parameters for a non-paresthesia stimulation pattern
#169SYSTEM AND METHOD FOR TREATING BRUXISM
#170Interferential stimulation method and system for neuromodulation
#171Brain stimulation response profiling
#172Klotho modulation
#173METHODS OF SENSING CROSS-FREQUENCY COUPLING AND NEUROMODULATION
#174Systems and methods for active charge-balancing for high-frequency neural stimulation
#175Wireless neurostimulators
#176Lead impedance monitoring for an implantable medical device
#177Cuff electrode
#178MANAGING THERAPY DELIVERY BASED ON PHYSIOLOGICAL MARKERS
#179SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS
#180Hearing prosthesis
#181Medial olivocochlear reflex sound coding with bandwidth normalization
#182Real-time phase detection of frequency band
#183Prescribed Neuromodulation Dose Delivery
#184Therapy implemented using different sub-perception neuromodulation types
#185CONTROLLED NEUROMODULATION SYSTEMS AND METHODS OF USE
#186Neurostimulation titration process via adaptive parametric modification
#187High frequency electrostimulation treatment for restless legs syndrome or periodic limb movement disorder
#188Systems and methods for restoring muscle function to the lumbar spine and kits for implanting the same
#189SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS
#190Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods
#191SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS
#192SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS
#193Systems and methods for monitoring neural activity
#194Systems and methods for monitoring neural activity
#195ONSET-MITIGATING HIGH-FREQUENCY NERVE BLOCK
#196Logging the execution of sub-programs within a stimulation program for an implantable stimulator device
#197Adaptive electrical neurostimulation treatment to reduce pain perception
#198Implantable and non-invasive stimulators for gastrointestinal therapeutics
#199Method and apparatus for charge balancing during delivery of electrical stimulation
#200Neuromodulation apparatus, method and system
#201Devices and methods for nerve stimulation
#202Multi-modal synchronization therapy
#203Batteryless implantable microstimulators
#204Spinal cord stimulator system
#205Methods and devices for treating parasympathetic bias mediated conditions
#206Bladder event detection for diagnosis of urinary incontinence or treatment of lower urinary tract dysfunction
#207Systems and methods for fast and reversible nerve block
#208Methods and systems for detecting atrial contraction timing fiducials within a search window from a ventricularly implanted leadless cardiac pacemaker
#209Methods and systems for detecting atrial contraction timing fiducials and determining a cardiac interval from a ventricularly implanted leadless cardiac pacemaker
#210Systems and methods for enhancing function of spine stabilization muscles associated with a spine surgery intervention
#211Systems and methods for monitoring neural activity
#212Method and system for adjusting a neurostimulation therapy
#213Active implantable medical device for nerve stimulation therapy with dynamic adjustment of stimulation periods
#214Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
#215Neural stimulation to treat sleep apnea
#216Restless leg syndrome or overactive nerve treatment
#217Methods and systems for generating stimulation waveforms for a neurostimulation therapy
#218Electrical stimulator configuration with initial high-density stimulation
#219Methods and apparatus for adjusting neurostimulation intensity using evoked responses
#220Neurostimulation titration utilizing T-wave alternans
#221Methods and systems for glucose regulation
#222Device and method for an effective invasive multi-segment neurostimulation
#223System and method for treating various neurological disorders using synchronized nerve activation
#224High duty cycle electrical stimulation therapy
#225High duty cycle electrical stimulation therapy
#226Apparatus for application of a pulsed radio frequency therapy in a vascular system or another cavity or tissue of the human or animal body
#227Systems and methods for restoring muscle function to the lumbar spine
#228Systems, methods, and devices for performing electronically controlled test stimulation
#229Enhanced Selectivity and Modulation in Coordinated Reset in Deep Brain Stimulation
#230SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS
#231Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods
#232SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS
#233System and method for interleaved neurostimulation
#234Stimulation of the ventral pallidum for the treatment of epilepsy
#235Stimulation of a hypoglossal nerve for controlling the position of a patient's tongue
#236Methods for providing optimized neurostimulation
#237SYNC PULSE DETECTOR
#238Devices, systems, and methods for improving pelvic floor dysfunction
#239Systems and methods for avoiding neural stimulation habituation
#240SYSTEMS AND METHODS FOR OPTIMIZING TARGETED NEUROPLASTICITY
#241Systems and methods for restoring muscle function to the lumbar spine and kits for implanting the same
#242Precision delivery of electrical stimulation
#243Implantable neurostimulator-implemented method for managing bradycardia through vagus nerve stimulation
#244High-contact density electrode and fabrication technique for an implantable cuff design
#245Systems and methods for active charge-balancing for high-frequency neural stimulation
#246Physician programmer with enhanced graphical user interface, and associated systems and methods
#247Method and Apparatus for Application of a Neural Stimulus
#248EXTREMELY LOW DUTY-CYCLE ACTIVATION OF THE CHOLINERGIC ANTI-INFLAMMATORY PATHWAY TO TREAT CHRONIC INFLAMMATION
#249Locally-polarized and globally unpolarized neuromodulation system and method
#250System for location-dependent therapy delivery
#251Onset-mitigating high-frequency nerve block
#252Pulse definition circuitry for creating stimulation waveforms in an implantable pulse generator
#253Systems and methods for spinal cord stimulation
#254Method and apparatus for neurostimulation with prevention of neural accommodation
#255System and Method for Interleaved Neurostimulation
#256ELECTROCEUTICAL DEVICE AND WRAP FOR USING THE SAME
#257Brain stimulation response profiling
#258Wireless neurostimulators
#259Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
#260Devices for controlling high frequency spinal cord modulation for inhibiting pain, and associated systems and methods, including simplified contact selection
#261Systems, methods and devices for paired plasticity
#262Stimulation of a hypoglossal nerve for controlling the position of a patient's tongue
#263CHOLINERGIC DEEP BRAIN STIMULATOR
#264Methods, systems, and devices for treating tinnitus with VNS pairing
#265Neurostimulation titration process via adaptive parametric modification
#266Stimulation suspension in response to patient discomfort or state
#267Neural stimulation to treat sleep apnea
#268Electrical stimulation therapy for inducing patient sensations
#269Systems and methods for avoiding neural stimulation habituation
#270Multi-channel neuromodulation system having frequency modulation stimulation
#271Systems and methods for restoring muscle function to the lumbar spine
#272Spatially selective nerve stimulation in high-frequency nerve conduction block and recruitment
#273Methods and systems for glucose regulation
#274Method for treating premature ejaculation and method for controlling premature ejaculation treatment device
#275Method and apparatus for application of a neural stimulus
#276Methods and apparatus for sensing cross-frequency coupling and neuromodulation
#277Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of parkinson's disease and/or other movement disorders
#278Systems, methods, and devices for performing electronically controlled test stimulation
#279Bladder event detection for diagnosis of urinary incontinence or treatment of lower urinary tract dysfunction
#280Coupled monopolar and multipolar pulsing for conditioning and stimulation
#281Onset-mitigating high-frequency nerve block
#282Systems and methods for restoring muscle function to the lumbar spine and kits for implanting the same
#283Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods
#284Timed delivery of electrical stimulation therapy
#285Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods
#286Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods
#287Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods
#288System for combining electrical waveforms into a combined electrical waveform
#289Devices for controlling high frequency spinal cord modulation for inhibiting pain, and associated systems and methods, including simplified program selection
#290Stimulation of a hypoglossal nerve for controlling the position of a patient's tongue
#291System and method for converting tissue stimulation programs in a format usable by an electrical current steering navigator
#292Neurostimulation titration process via adaptive parametric modification
#293Methods and apparatus for adjusting neurostimulation intensity using evoked responses
#294Neurostimulation titration utilizing T-wave alternans
#295Method and apparatus for programming complex neurostimulation patterns
#296Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
#297Systems and methods for avoiding neural stimulation habituation
#298Systems and methods for providing therapy using electrical stimulation to disrupt neuronal activity
#299System and methods for diagnosis and treatment of discogenic lower back pain
#300System and methods for diagnosis and treatment of discogenic lower back pain