95427 ⎘
Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Sub-classes:NOVEL INTERMEDIATE, METHOD FOR PREPARING THE SAME AND APPLICATION THEREOF
#2Preparation of Buprenorphine
#3A METHOD FOR EXTRACTION OF ALKALOID
#4TRANSCRIPTION FACTOR
#5Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
#6MORPHINAN ISOMERS AND THEIR STRUCTURAL MODIFICATIONS AS NMDAR ANTAGONISTS AND NEUROPLASTOGENS
#7PROCESS FOR PREPARING OXYCODONE HYDROCHLORIDE HAVING LESS THAN 25 PPM 14-HYDROXYCODEINONE
#8COMPOSITIONS AND METHODS FOR THE TREATMENT OF PAIN AND DEPENDANCE DISORDERS
#96-acetylmorphine analogs, and methods for their synthesis and use
#10Opioid ketal compounds and uses thereof
#11Compositions and methods of use for opioid hexadienoates and optionally substituted hexadienoates
#12Demethylation of reticuline and derivatives thereof with fungal cytochrome P450
#13Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
#14Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
#15Opioid ketal compounds and uses thereof
#16Opioid ketal compounds and uses thereof
#17Process for improved oxycodone synthesis
#18(+)-morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof
#19Process for preparing oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone
#20OLIGOMER-OPIOID AGONIST CONJUGATES
#21Process for preparing oxycodone compositions
#22Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
#23Opioid ketal compounds and uses thereof
#24Hydrocodone base and methods for its purification
#25Pharmaceutically acceptable salts and polymorphic forms of hydrocodone benzoic acid enol ester and processes for making same
#26PHARMACEUTICALLY ACCEPTABLE SALTS AND POLYMORPHIC FORMS OF HYDROCODONE BENZOIC ACID ENOL ESTER AND PROCESSES FOR MAKING SAME
#27OLIGOMER-OPIOID AGONIST CONJUGATES
#28Process for the Preparation of Oxymorphone Alkaloid and Oxymorphone Salts
#29Process for preparing oxycodone compositions
#30Compositions and Methods For Making Alkaloid Morphinans
#31Direct C—H amination and aza-annulation
#32Process for improved oxycodone synthesis
#33METHOD FOR CATALYTIC PREPARATION OF HYDROMORPHONE, HYDROCODONE, AND OTHER OPIATES
#34Oligomer-opioid agonist conjugates
#35Process for preparing hydromorphone and derivatives thereof
#366-ACETYLMORPHINE ANALOGS, AND METHODS FOR THEIR SYNTHESIS AND USE
#37strain with high concentration of thebaine
#38Process for improved oxymorphone synthesis
#39Morphinan derivative and medical usage thereof
#40Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
#41Stimulant abuse-deterrent compositions
#42Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
#43Pharmaceutically acceptable salts and polymorphic forms of hydrocodone benzoic acid enol ester and processes for making same
#44Process for preparing oxycodone compositions
#45Method for catalytic preparation of hydromorphone, hydrocodone, and other opiates
#46Conjugates for assays for oxycodone and oxymorphone
#476-acetylmorphine analogs, and methods for their synthesis and use
#48Papaver somniferum with high concentration of codeine
#49Dihydroetorphines and their preparation
#50Compositions and methods for making alkaloid morphinans
#51PROCESS FOR IMPROVED OXYMORPHONE SYNTHESIS
#52METHODS FOR MAKING 3-O-PROTECTED MORPHINONES AND 3-O-PROTECTED MORPHINONE DIENOL CARBOXYLATES
#53Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and uses thereof
#54Method of preparing buprenorphine
#556-(AMINO ACID)-MORPHINAN DERIVATIVES IN COMBINATION WITH PERMEATION ENHANCERS FOR USE AS AN ORALLY, RECTALLY, TRANSDERMALLY OR NASALLY ADMINISTERED MEDICAMENT
#56Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof
#57Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and uses thereof
#58Selective reduction of morphinan alkaloids
#59Method of treating pain using an acetaminophen dimer ether-linked through phenolic hydroxyl groups
#60(+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
#61Process for reducing contaminating Michael acceptor levels in oxycodone and other compositions
#62Process for improved oxycodone synthesis
#63Process for improved oxymorphone synthesis
#64Peripherally acting opioid compounds
#65Oligomer-opioid agonist conjugates
#66Buprenorphine dimer and its use in treatment of gastrointestinal disorders
#67Polymorphic forms of naltrexone
#68Opioid compounds and their uses
#69Opioid ketal compounds and uses thereof
#70Process for preparing oxycodone compositions
#71Oligomer-opioid agonist conjugates
#72Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and uses thereof
#73Preparation of saturated ketone morphinan compounds by catalytic isomerisation
#74Synthesis of noroxymorphone from morphine
#75Processes for making hydrocodone, hydromorphone and their derivatives
#76Processes for making hydrocodone, hydromorphone and their derivatives
#77Oligomer-opioid agonist conjugates
#78Dihydroetorphines and their preparation
#79Analgesic compounds and methods of use
#80Deuterated morphine derivatives
#81Methods of treating pain or fever using pharmaceutically active acetaminophen dimers linked through phenolic hydroxyl groups
#82Pharmaceutically acceptable salts and polymorphic forms of hydrocodone benzoic acid enol ester and processes for making same
#83Use of buprenorphine dimer in the treatment of peripheral neuropathic pain
#84strain with high concentration of thebaine
#856-acetylmorphine analogs, and methods for their synthesis and use
#86Mixed μ agonist/ δ antagonist opioid analgesics with reduced tolerance liabilities and uses thereof
#87Heroin Haptens, Immunoconjugates and Related Uses
#88Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
#89(+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
#90Pharmaceutically active dimers linked through phenolic hydroxyl groups
#91Buprenorphine dimer and its use in treatment of gastrointestinal disorders
#92Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
#93Oxycodone compositions
#94Processes for making hydrocodone, hydromorphone and their derivatives
#95Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates
#96Oligomer-opioid agonist conjugates
#97Methods for the preparation of hydromorphone
#98Buprenorphine analogs
#99Peripherally acting opioid compounds
#100Process for the Preparation of Quaternary N-Alkyl Morphinan Alkaloid Salts
#101Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
#102Process for reducing contaminating Michael acceptor levels in oxycodone and other compositions
#103Controlled Release of Phenolic Opioids
#104Preparation of normorphinans
#105Compositions and methods for the treatment of chronic pain
#106CHEMICAL TRANSFORMATIONS OF (-)-CODEINE TO AFFORD DERIVATIVES OF CODEINE AND MORPHINE THEREOF
#107Method of preparing oxymorphone
#108Dihydroetorphines and their preparation
#109Oligomer-opioid agonist conjugates
#110Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
#111Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
#112Heterocycle-fused morphinans, use thereof and preparation thereof
#113Process for N-dealkylation of tertiary amines
#114Process for the preparation of oxymorphone alkaloid and oxymorphone salts
#115Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
#116Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
#117Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
#1185-METHYLDIHYDROMORPHONE COMPOUNDS FOR TREATMENT OF PAIN
#1198-CARBOXAMIDO-2,6-METHANO-3-BENZAZOCINES
#120Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain
#121Method of preparing buprenorphine
#122Opioid prodrugs with heterocyclic linkers
#123Oligomer-opioid agonist conjugates
#124Oligomer-opioid agonist conjugates
#125Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates
#126Halogenated phenols for diagnostics, antioxidant protection and drug delivery
#127Halogenated phenols for diagnostics, antioxidant protection and drug delivery
#128Process for preparing oxymorphone, naltrexone, and buprenorphine
#129Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
#130with high concentration of codeine
#131One pot process for producing 6-hydroxyl nal-opiate
#132Therapeutic or prophylactic agent for biliary diseases
#133Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
#134Compositions Comprising Enzyme-Cleavable Hydromorphone Prodrug
#135Peripheral Opioid Agonists and Peripheral Opioid Antagonists
#136Production of alkaloids without the isolation of intermediates
#1374-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators
#138Halogenated phenols for diagnostics, antioxidant protection and drug delivery
#139Stereoselective reduction of a morphinone
#140HALOGENATED PHENOLS FOR DIAGNOSTICS, ANTIOXIDANT PROTECTION AND DRUG DELIVERY
#141HALOGENATED PHENOLS FOR DIAGNOSTICS, ANTIOXIDANT PROTECTION AND DRUG DELIVERY
#142Oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone
#143Peripherally acting opioid compounds
#144Methods of using 8-carboxamido-2,6-methano-3-benzazocines
#145Opioid prodrugs with heterocyclic linkers
#146Oligomer-opioid agonist conjugates
#147Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
#148Controlled release of phenolic opioids
#149Oligomer-opioid agonist conjugates
#150Compositions comprising enzyme-cleavable ketone-modified opioid prodrugs and optional inhibitors thereof
#151Method for the N-demethylation of N-methyl heterocycles
#152Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates
#153Process for reducing the 6-keto group of a morphinan alkaloid to the 6-hydroxy group by hydrogenation
#154PROCESS FOR PREPARING OXYMORPHONE, NALTREXONE, AND BUPRENORPHINE
#155Oligomer-opioid agonist conjugates
#156PROCESS FOR PREPARING OXYMORPHONE, NALTREXONE, AND BUPRENORPHINE
#157Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
#158Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
#159Sinomenine derivatives and processes for their synthesis
#160Opioid and opioid-like compounds and uses thereof
#161Preparation of opiate analgesics by reductive alkylation
#162Processes for the preparation of morphinane and morphinone compounds
#163Novel Therapeutic Compounds
#164Tandem process for preparing N-alkyl morphinans
#165N-demethylation of 6-keto morphinans
#166Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates
#167Dihydroetorphines and Their Preparation
#168Methods for one-pot -demethylation/-functionalization of morphine and tropane alkaloids
#169Synthesis of morphine-6-glucuronide or one of the derivatives thereof
#170Preparation of saturated ketone morphinan compounds having low metal content
#171COMPOSITIONS COMPRISING ENZYME-CLEAVABLE PRODRUGS OF ACTIVE AGENTS AND INHIBITORS THEREOF
#172COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF
#173Opioid and opioid-like compounds and uses thereof
#1748-carboxamido-2,6-methano-3-benzazocines
#175OXYCODONE HYDROCHLORIDE HAVING LESS THAN 25 PPM 14-HYDROXYCODEINONE
#176PREPARATION OF OPIATE ANALGESICS BY REDUCTIVE ALKYLATION
#177Process for reducing contaminating michael acceptor levels in oxycodone and other compositions
#178Buprenophine analogs
#179(+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
#180Process for the synthesis of morphinane compounds and intermediates thereof
#181Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
#182Methods for producing hydrocodone, hydromorphone or a derivative thereof
#183Preparation of 10-keto morphinans by benzylic oxidation
#184Heterogeneous ruthenium metal catalyst for the production of hydrocodone, hydromorphone or a derivative thereof
#1853-oxy-hydromorphone derivatives
#186(+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof
#187Method for the enrichment of buprenorphine using chromatographic techniques
#188THERAPEUTIC TABLET FOR POSTHERPETIC NEURALGIA AND METHOD OF TREATING POSTHERPETIC NEURALGIA
#189Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
#190Cross-conjugated 2,5-cyclohexadienone and related synthesis methods
#191Efficient synthesis of morphine and codeine
#192Efficient synthesis of galanthamine
#193NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF
#194Process for preparing oxymorphone, naltrexone, and buprenorphine
#195Preparation of saturated ketone morphinan compounds
#196Preparation of 6-Keto, 3-Alkoxy Morphinans
#197Ruthenium Catalysts for the Production of Hydrocodone, Hydromorphone or a Derivative Thereof
#198Preparation of saturated ketone morphinan compounds by catalytic isomerization
#199Papaver somniferum with high concentration of codeine
#200(+)-morphinanium N-oxides and processes for their production
#201(+)-morphinanium quaternary salts and processes for their production
#202(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
#203Oral preparation comprising specific organic acid, and method for improvement in elution property and chemical stability of oral preparation
#204Preparation of N-alkylated opiates by reductive amination
#205Synthesis of metabolically stable analgesics, pain medications and other agents
#2068a,14-dihydroxy-7,8-dihydrocodeinone
#207Process for preparing hydrocodone using a super acid
#208Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
#209Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
#210Polymorphs of 6-beta-naltrexol
#211Processes for the synthesis of five and six membered heterocyclic rings
#212Opiate reduction utilizing catalytic hydrogen transfer reaction
#213Oligomer-opioid agonist conjugates
#214Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
#215Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
#216Controlled release of phenolic opioids
#217Process for the preparation of 6-beta hydroxy morphinan compounds
#218Processes and compounds for the preparation of normorphinans
#219ANALGESIC CONJUGATES
#220strain with high concentration of thebaine
#221Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
#222Process for the preparation of 3-hydroxymorphinan derivatives
#223Stereoselective reduction of a morphinone
#224Opioid and opioid-like compounds and uses thereof
#225Sinomenine derivatives and processes for their synthesis
#226N-demethylation of N-methyl morphinans
#227Transdermally deliverable opioid prodrugs, abuse-resistant compositions and methods of using opioid prodrugs
#228METHODS OF TREATING PAIN
#229Method for decreasing opioid metabolism
#230Morphine compounds for pharmaceutical compositions
#231Methods for -demethylation of morphine and tropane alkaloids
#232Conversion of thebaine to morphine derivatives
#233PREPARATION OF OXYCODONE
#234Use of oripavine as a starting material for buprenorphine
#235PREPARATION OF OXYCODONE
#236Processes for preparing morphinans and intermediates thereof
#237Method for catalytic preparation of hydromorphone and hydrocodone
#238Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates
#239ABUSE-RESISTANT HYDROCODONE COMPOUNDS, COMPOSITIONS AND METHODS OF USING THE SAME
#240Transdermally deliverable opioid prodrugs, abuse-resistant compositions and methods of using opioid prodrugs
#241Process for the synthesis of morphinane compounds and intermediates thereof
#242Preparation of opiate analgesics by reductive alkylation
#243Preparation and utility of opioid analgesics
#244Method for separation and purification of hydrocodone by preparative chromatography
#245Preparation of oxycodone
#246Extraction of alkaloids from opium
#247Methods for treating diseases with 4-hydroxybenzomorphans
#248PREPARATION OF OXYCODONE
#2496-monoacetylmorphine derivatives useful in immunoassay
#250Oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone
#251Process for reducing contaminating Michael acceptor levels in oxycodone and other compositions
#2526-monoacetylmorphine derivatives useful in immunoassay
#253Prodrugs of active agents
#254Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
#255Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
#256Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
#257Hydrocodone polymorphs
#258Preparation of oxycodone
#259Opioid receptor agonist compounds and their use in treatment of pain
#260Hydromorphone polymorphs
#261Oxycodone hydrochloride having less than 25 ppm 14- hydroxycodeinone
#262Production of opioid analgesics
#263Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
#2644-hydroxybenzomorphans
#265Preparation of oxycodone
#266Amidine compounds
#267Method for the catalytic production of hydrocodone and hydromorphone
#268Method for decreasing opioid metabolism
#269Process for the synthesis of hydromorphone
#270Process for the production of opiates
#271Opioid and opioid-like compounds and uses thereof
#272Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
#273Narcotic-NSAID ion pairs
#274Method for labeling with tritium
#275Method for the catalytic production of hydrocodone and hydromorphone
#276Opioid and opioid-like compounds and uses thereof
#2771-alkyl-4-(3-substitutedphenyl)piperidines
#278C-14 oxidation of morphine derivatives
#279Morphinan derivative