95430 ⎘
Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14 Oxygen atom
ANALGESIC DELTA OPIOID RECEPTOR BITOPIC LIGANDS
#2NOVEL INTERMEDIATE, METHOD FOR PREPARING THE SAME AND APPLICATION THEREOF
#3METHOD FOR PREPARING NALDEMEDINE
#4NALTREXAMINE DERIVATIVES BEARING 5-MEMBER HETEROCYCLIC RING SYSTEMS AND OPIOID RECEPTOR MODULATORS
#5OPIOID RECEPTOR ANTAGONIST PRODRUGS
#6BIVALENT LIGANDS TO UNDERSTAND DIMERIZATION OF THE MU OPIOID RECEPTOR AND THE CHEMOKINE RECEPTOR CCR5 IN NEUROLOGICAL DISORDERS
#7PROCESS FOR CRYSTALLIZING NALMEFENE HYDROCHLORIDE
#8PROCESS FOR PURIFYING NOROXYMORPHONE
#9Treatment of Cancer with Naltrexone
#10Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
#11NOVEL PROCESS FOR THE SYNTHESIS OF NOROXYMORPHONE FROM MORPHINE
#12PROCESS FOR PREPARING OXYCODONE HYDROCHLORIDE HAVING LESS THAN 25 PPM 14-HYDROXYCODEINONE
#13PROCESS FOR IMPROVED OPIOID SYNTHESIS
#14OPIOID RECEPTOR ANTAGONISTS
#15ABUSE-RESISTANT LONG-ACTING RELEASE OPIOID PRODRUGS
#16COMPOSITIONS AND METHODS FOR THE TREATMENT OF PAIN AND DEPENDANCE DISORDERS
#17METHOD FOR PREPARING NALDEMEDINE
#18PROCESSES FOR PREPARING MORPHINAN-6-ONE PRODUCTS WITH LOW LEVELS OF ALPHA, BETA-UNSATURATED KETONE COMPOUNDS
#19Opioid ketal compounds and uses thereof
#20Treatment of Cancer With Naltrexone
#21Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
#22PROCESS FOR THE PREPARATION OF MORPHINANE COMPOUNDS
#23Opioid receptor antagonist conjugate and use thereof
#24Process for improved opioid synthesis
#25Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
#26Opioid compounds and uses thereof
#27Morphinan Derivatives with High Oral Bioavailability
#28PROCESSES FOR PREPARING MORPHINAN-6-ONE PRODUCTS WITH LOW LEVELS OF a,ß-UNSATURATED KETONE COMPOUNDS
#29Opioid ketal compounds and uses thereof
#30Opioid ketal compounds and uses thereof
#31REDUCTION OF ALPHA, BETA-UNSATURATED KETONE LEVELS IN MORPHINAN DERIVATIVE COMPOSITIONS
#32Non-peptide opioid receptor modulators
#33Process for improved oxycodone synthesis
#34(+)-morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof
#35Abuse-resistant long-acting release opioid prodrugs
#36ORAL FORMULATIONS AND LIPOPHILIC SALTS OF METHYLNALTREXONE
#37Process for preparing oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone
#38Process for preparing oxycodone compositions
#39Opioid ketal compounds and uses thereof
#40Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof
#41PROCESSES FOR PREPARING MORPHINAN-6-ONE PRODUCTS WITH LOW LEVELS OF a,ß-UNSATURATED KETONE COMPOUNDS
#42PROCESS FOR IMPROVED OPIOID SYNTHESIS
#43Oral formulations and lipophilic salts of methylnaltrexone
#44Processes for making opioids including 14-hydroxycodeinone and 14-hydroxymorphinone
#45Opioid receptor antagonist prodrugs
#46DUAL MODULATORS OF BOTH MU AND KAPPA OPIOID RECEPTORS
#47PROCESS FOR IMPROVED OPIOID SYNTHESIS
#48Process for the Preparation of Oxymorphone Alkaloid and Oxymorphone Salts
#49Polymorphic forms of naltrexone
#50Process for preparing oxycodone compositions
#51Potent and selective mu opioid receptor modulators
#52Compositions and Methods For Making Alkaloid Morphinans
#53Processes And Oxazolidine-Containing Intermediates For The Preparation Of Morphine Analogs And Derivatives
#54Oral formulations and lipophilic salts of methylnaltrexone
#55Oral formulations and lipophilic salts of methylnaltrexone
#56Process for improved oxycodone synthesis
#57METHOD FOR CATALYTIC PREPARATION OF HYDROMORPHONE, HYDROCODONE, AND OTHER OPIATES
#58Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof
#59Process for the synthesis of substituted morphinans
#60Process for improved oxymorphone synthesis
#61Morphinan derivative and medical usage thereof
#62Polymorphic forms of naltrexone
#63SALTS AND COMPOSITIONS USEFUL FOR TREATING DISEASE
#64Alpha-hydroxy carboxylic acid and derivatives and other GRAS based prodrugs of oxycodone and uses thereof
#65Crystalline salts of naloxone and naltrexone
#66Cocrystals of naloxone and naltrexone
#67Therapeutic compounds
#68TREATMENT OF CANCER WITH NALTREXONE
#69Process for improved opioid synthesis
#70Polymorphic forms of naltrexone
#71Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
#726-amido derivatives of 4,5A-epoxymorphinans for treatment of pain
#73Process for preparing oxycodone compositions
#74Processes For Preparing Morphinan-6-One Products With Low Levels Of Alpha, Beta-Unsaturated Ketone Compounds
#75Conjugates for assays for oxycodone and oxymorphone
#76REDUCTION OF ALPHA, BETA-UNSATURATED KETONE LEVELS IN MORPHINAN DERIVATIVE COMPOSITIONS
#77Salts and compositions useful for treating disease
#78Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof
#79Nalmefene salts as medicaments for reducing alcohol consumption or for preventing excessive alcohol consumption
#80Alpha-hydroxy carboxylic acid and derivatives and other GRAS based prodrugs of oxycodone and uses thereof
#81Compositions and methods for making alkaloid morphinans
#82Method of preparing buprenorphine
#838-carboxamido-2,6-methano-3-benzazocines
#84Polymorphic forms of naltrexone
#85Methods and compositions for preventing opioid abuse
#86Alpha-hydroxy carboxylic acid and derivatives and other GRAS based prodrugs of oxycodone and uses thereof
#87Methods and compositions for preventing opioid abuse
#88Crystalline, anhydrous forms of oxymorphone hydrochloride
#89Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
#90Method of treating pain using an acetaminophen dimer ether-linked through phenolic hydroxyl groups
#91(+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
#92Process for reducing contaminating Michael acceptor levels in oxycodone and other compositions
#93O-demethylating process of methoxy substituted morphinan-6-one derivatives
#94Process for improved oxycodone synthesis
#95Peripheral opioid receptor antagonists and uses thereof
#96Buprenorphine dimer and its use in treatment of gastrointestinal disorders
#97Polymorphic forms of naltrexone
#98Process For The Preparation Of Oxymorphone Freebase
#99Methods and compositions for preventing opioid abuse
#100Compounds for treating pruritic conditions
#101Opioid compounds and their uses
#102Opioid ketal compounds and uses thereof
#103PROCESS FOR PREPARING OXYCODONE COMPOSITIONS
#104Process for preparing oxycodone compositions
#105OPIOID KETAL COMPOUNDS AND USES THEREOF
#106Process of preparing low ABUK oxymorphone hydrochloride
#107Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
#108PROCESS FOR PREPARING OXYCODONE COMPOSITIONS
#109PROCESS FOR PREPARING OXYCODONE COMPOSITIONS
#110PROCESS FOR PREPARING OXYCODONE COMPOSITIONS
#111PROCESS FOR PREPARING OXYCODONE COMPOSITIONS
#112PROCESS FOR PREPARING OXYCODONE COMPOSITIONS
#113Process for the preparation of morphinan-6-one compounds
#114PROCESS FOR N-DEALKYLATION OF TERTIARY AMINES
#115Synthesis of noroxymorphone from morphine
#116Nalmefene salts as medicaments for reducing alcohol consumption or for preventing excessive alcohol consumption
#117Polymorphic forms of naltrexone
#118Peripheral opioid receptor antagonists and uses thereof
#119Treatment of cancer with naltrexone
#120Crystal forms of (R)-N-methylnaltrexone bromide and uses thereof
#121Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone
#122Methods of treating pain or fever using pharmaceutically active acetaminophen dimers linked through phenolic hydroxyl groups
#123Use of buprenorphine dimer in the treatment of peripheral neuropathic pain
#124Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
#125Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
#126Mixed μ agonist/ δ antagonist opioid analgesics with reduced tolerance liabilities and uses thereof
#127Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
#128Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
#129Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
#130Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
#131Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
#132(+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
#133Process for the preparation of opioid compounds
#134Process for the preparation of opioid compounds
#135Process for improved opioid synthesis
#136Pharmaceutically active dimers linked through phenolic hydroxyl groups
#137Buprenorphine dimer and its use in treatment of gastrointestinal disorders
#138Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
#139Synthesis of (R)-N-methylnaltrexone
#140Oxycodone compositions
#141PROCESS FOR IMPROVED OPIOID SYNTHESIS
#142Polymorphic forms of naltrexone
#143Compositions comprising enzyme-cleavable oxycodone prodrug
#144Preparation of oxycodone base form 14-hydroxycodeinone sulfate
#145Preparation of 14-hydroxycodeinone sulfate
#146Preparation of 14-hydroxycodeinone sulfate
#147Preparation of 14-hydroxycodeinone sulfate
#148Synthesis of oxycodone hydrochloride
#149Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
#150Peripheral opioid receptor antagonists and uses thereof
#151Process for reducing contaminating Michael acceptor levels in oxycodone and other compositions
#152Crystalline, anhydrous forms of oxymorphone hydrochloride
#153Controlled Release of Phenolic Opioids
#154Compositions and methods for the treatment of chronic pain
#155Method of preparing oxymorphone
#156Production of 6-hydroxy morphinans without the isolation of intermediates
#157Convenient preparation of N-substituted morphinan-6-ols from morphinan-6-ones
#158Carboxamide bioisosteres of opiates
#159Morphinan Derivatives with High Oral Bioavailability
#160Heterocycle-fused morphinans, use thereof and preparation thereof
#161Process for N-dealkylation of tertiary amines
#162Large substituent, non-phenolic opioids and methods of use thereof
#163Process for the preparation of oxymorphone alkaloid and oxymorphone salts
#164Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans
#165Non-peptidyl, potent, and selective mu opioid receptor antagonists and their use in treating opioid addiction and opioid induced constipation
#166Bivalent ligands for the treatment of neurological disorders
#167Process for the synthesis of substituted morphinans
#168Polymorphic forms of naltrexone
#169Process for recovery of nalmefene hydrochloride
#1706-amido derivatives of 4, 5-a epoxymorphinans for the treatment of pain
#171Oral formulations and lipophilic salts of methylnaltrexone
#172Method of preparing buprenorphine
#173LOW ABUK OXYCODONE, ITS SALTS AND METHODS OF MAKING SAME
#174Opioid prodrugs with heterocyclic linkers
#175Carboxamide bioisosteres of opiates
#176Compositions comprising enzyme-cleavable oxycodone prodrug
#177METHOD FOR THE MANUFACTURING OF NALTREXONE
#178Peripheral opioid receptor antagonists and uses thereof
#179Crystalline, anhydrous forms of oxymorphone hydrochloride
#180Peripheral opioid receptor antagonists and uses thereof
#181Process for preparing oxymorphone, naltrexone, and buprenorphine
#182Process
#183(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
#184Selective opioid compounds
#185Crystal forms of (R)-N-methylnaltrexone bromide and uses thereof
#186Large substituent, non-phenolic opioids and methods of use thereof
#187Nalmefene hydrochloride dihydrate
#188Oral formulations and lipophilic salts of methylnal trexone
#189Preparation and use of (R),(R)-2,2′-bis-methylnaltrexone
#1906-AMIDO DERIVATIVES OF 4, 5-a EPOXYMORPHINANS FOR THE TREATMENT OF PAIN
#191Novel 6-Amino-Morphinan Derivatives, Method of Manufacturing Them and Their Application as Analgesics
#192Polymorphic forms of naltrexone
#193Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
#194Compositions Comprising Enzyme-Cleavable Prodrugs of Active Agents and Inhibitors Thereof
#195Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
#196One pot process for producing 6-hydroxyl nal-opiate
#197Therapeutic or prophylactic agent for biliary diseases
#198Process for N-dealkylation of tertiary amines
#199Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
#2004-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators
#201Preparation of low impurity opiates in a continuous flow reactor
#202Peripheral opioid receptor antagonists and uses thereof
#203Oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone
#204PROCESS FOR PREPARING OXYMORPHONE, NALTREXONE, AND BUPRENORPHINE
#205Peripheral opioid receptor antagonists and uses thereof
#206Quaternary opioid carboxamides
#207Methods of using 8-carboxamido-2,6-methano-3-benzazocines
#208Opioid prodrugs with heterocyclic linkers
#209Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
#210Processes and intermediates in the preparation of morphine analogs via N-demethylation of N-oxides using cyclodehydration reagents
#211Controlled release of phenolic opioids
#212Low ABUK oxycodone, its salts and methods of making same
#213Process for the synthesis of quaternary amine compounds
#214Compositions comprising enzyme-cleavable ketone-modified opioid prodrugs and optional inhibitors thereof
#215Method for the N-demethylation of N-methyl heterocycles
#216Process for reducing the 6-keto group of a morphinan alkaloid to the 6-hydroxy group by hydrogenation
#217PROCESS FOR PREPARING OXYMORPHONE, NALTREXONE, AND BUPRENORPHINE
#218Compositions comprising enzyme-cleavable oxycodone prodrug
#219Compositions comprising enzyme-cleavable oxycodone prodrug
#220PROCESS FOR PREPARING OXYMORPHONE, NALTREXONE, AND BUPRENORPHINE
#221(S)--methylnaltrexone
#2226,7-unsaturated-7-carbamoyl substituted morphinan derivative
#223Preparation of nalmefene hydrochloride from naltrexone
#224Method for the manufacturing of naltrexone
#225Opioid and opioid-like compounds and uses thereof
#226Oral formulations and lipophilic salts of methylnaltrexone
#227Processes for preparing morphinan-6-one products with low levels of alpha beta-unsaturated compounds
#228Preparation of opiate analgesics by reductive alkylation
#229N-demethylation of 6-keto morphinans
#230Process for the Synthesis of Substituted Morphinans
#231Methods for one-pot -demethylation/-functionalization of morphine and tropane alkaloids
#232Large substituent, non-phenolic opioids and methods of use thereof
#233COMPOSITIONS COMPRISING ENZYME-CLEAVABLE PRODRUGS OF ACTIVE AGENTS AND INHIBITORS THEREOF
#234COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF
#235Nalmefene hydrochloride dihydrate
#236Analgesic agents
#237Opioid and opioid-like compounds and uses thereof
#238Carboxamide bioisosteres of opiates
#2398-carboxamido-2,6-methano-3-benzazocines
#240OXYCODONE HYDROCHLORIDE HAVING LESS THAN 25 PPM 14-HYDROXYCODEINONE
#241Peripheral opioid receptor antagonists and uses thereof
#242PREPARATION OF OPIATE ANALGESICS BY REDUCTIVE ALKYLATION
#243Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
#244Process for reducing contaminating michael acceptor levels in oxycodone and other compositions
#245(+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
#246Process for preparing oxymorphone
#247Morphinan derivatives and preparation methods thereof
#248Prodrugs of Peripheral Phenolic Opioid Antagonists
#249Preparation and use of (R),(R)-2,2′-bis-methylnaltrexone
#250Process for the synthesis of morphinane compounds and intermediates thereof
#251Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia
#252Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
#253Preparation of 10-keto morphinans by benzylic oxidation
#254NALMEFENE DI-ESTER PRODRUGS
#255Nalmefene prodrugs
#256(+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof
#257Process for preparing oxymorphone
#258Crystalline forms of naltrexone methobromide
#259Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
#260Synthesis of -methylnaltrexone
#261CRYSTAL FORMS OF (R)-N-METHYLNALTREXONE BROMIDE AND USES THEREOF
#262Cross-conjugated 2,5-cyclohexadienone and related synthesis methods
#263Efficient synthesis of morphine and codeine
#264Efficient synthesis of galanthamine
#265Process for preparing oxymorphone, naltrexone, and buprenorphine
#266Prodrugs of Peripheral Phenolic Opioid Antagonists
#267Method for the preparation of morphine compounds
#268MORPHINAN DERIVATIVES WITH HIGH ORAL BIOAVAILABILITY
#269SKIN PROPERTY-IMPROVING THERAPEUTIC AGENT COMPRISING A MORPHINAN DERIVATIVE OR ANY OF ITS PHARMACOLOGICALLY PERMISSIBLE ACID ADDITION SALTS AS AN ACTIVE INGREDIENT
#270Process for the reductive alkylation of normorphinans
#271SOLVENT-FREE CRYSTALLINE FORM OF NALTREXONE
#272Preparation of N-alkylated opiates by reductive amination
#273Method for separation and purification of naltrexone by preparative chromatography
#274Method for producing N-methylnaltrexone bromide
#275Crystalline micropowder particles
#276Remedy or preventive for integration dysfunction syndrome
#2778a,14-dihydroxy-7,8-dihydrocodeinone
#278N-methylnaltrexone zwitterion
#279Therapeutic or prophylactic agent for dyskinesia
#280Crystalline and amorphous forms of naltrexone hydrochloride
#281Peripheral opioid receptor antagonists and uses thereof
#282Preparation of oxymorphone from oripavine
#283()--methylnaltrexone
#284Polymorphs of 6-beta-naltrexol
#285Opiate reduction utilizing catalytic hydrogen transfer reaction
#286Process for making morphinan-6α-ols
#287Controlled release of phenolic opioids
#288Processes and compounds for the preparation of normorphinans
#289Process for purifying noroxymorphone compounds
#290Large substituent, non-phenolic opioids and methods of use thereof
#291Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
#2926-Aminomorphinane Derivatives, Method for the Production and Use Thereof
#293Selective opioid compounds
#2946,7-unsaturated-7-carbamoyl substituted morphinan derivative
#295Quaternary opioid carboxamides
#296AMINO ACID AND PEPTIDE PRODRUGS OF OPIOID ANALGESICS WITH REDUCED GI SIDE-EFFECTS
#297AMINO ACID PEPTIDE PRO-DRUGS OF PHENOLIC ANALGESICS AND USES THEREOF
#298Antitussive agent
#299Opioid and opioid-like compounds and uses thereof
#300Demethylation of 14-hydroxy substituted alkaloid derivatives