ClassID:

96420

C07H19/048 - CPC Classification

Classification description:

Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives thereof sharing nitrogen; Heterocyclic radicals containing only nitrogen atoms as ring hetero atom Pyridine radicals

Recent Application in this class:
#1
20260062436
2026-03-05

METHODS OF PREPARING REDUCED NICOTINAMIDE RIBOSIDE AND DERIVATIVES THEREOF

#2
20260015377
2026-01-15

CRYSTALLINE FORM I OF REDUCED NICOTINAMIDE MONONUCLEOTIDE DISODIUM MONOHYDRATE AND PREPARATION METHOD THEREFOR

#3
20250388616
2025-12-25

POLYMORPHIC FORM OF REDUCED ß-NICOTINAMIDE MONONUCLEOTIDE CALCIUM SALT, AND PREPARATION METHOD AND USE THEREFOR

#4
20250361259
2025-11-27

AMORPHOUS FORM OF REDUCED ß-NICOTINAMIDE MONONUCLEOTIDE CALCIUM SALT, AND PREPARATION METHOD AND USE THEREFOR

#5
20250243234
2025-07-31

METHOD OF MAKING NICOTINAMIDE RIBOFURANOSIDE SALTS, NICOTINAMIDE RIBOFURANOSIDE SALTS AS SUCH, AND USES THEREOF

#6
20250171485
2025-05-29

CRYSTAL FORMS OF BETA-NICOTINAMIDE MONONUCLEOTIDE

#7
20250163094
2025-05-22

NICOTINAMIDE RIBOSIDE HYDROGEN MALATE CRYSTAL, AND ITS PREPARATION METHOD AND APPLICATION

#8
20250163093
2025-05-22

EFFICIENT AND SCALABLE SYNTHESES OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, MODIFIED DERIVATIVES THEREOF, PHOSPHORYLATED ANALOGS THEREOF, ADENYLYL DINUCLEOTIDE CONJUGATES THEREOF, AND NOVEL CRYSTALLINE FORMS THEREOF

#9
20250163092
2025-05-22

POLYMORPHIC FORM OF REDUCED BETA-NICOTINAMIDE MONONUCLEOTIDE DISODIUM SALT, AND PREPARATION METHOD THEREFOR AND USE THEREOF

#10
20250145652
2025-05-08

INORGANIC SALTS OF NICOTINAMIDE MONONUCLEOTIDE AS ANTI-AGING AGENTS

#11
20250092079
2025-03-20

METHOD OF MAKING NICOTINAMIDE RIBOFURANOSIDE SALTS, NICOTINAMIDE RIBOFURANOSIDE SALTS AS SUCH, AND USES THEREOF

#12
20250026777
2025-01-23

COCRYSTALS OF NICOTINAMIDE RIBOSIDE SALTS, CRYSTALLINE FORMS, METHODS OF PREPARATION, AND APPLICATIONS THEREOF

#13
20240417421
2024-12-19

NMN And Derivatives For Its Use In The Treatment Of Depression And/Or Anxiety In Patients Having A Form Of Parkinsonism

#14
20240368204
2024-11-07

SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF

#15
20240350523
2024-10-24

NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES AND THEIR USES

#16
20240343752
2024-10-17

NOVEL BICYCLIC NUCLEOSIDES AND OLIGOMERS PREPARED THEREFROM

#17
20240247022
2024-07-25

A Process for Synthesis of Nicotinamide Riboside Chloride (NRCL)

#18
20240240217
2024-07-18

NUCLEOSIDES AND NUCLEOTIDES WITH 3' BLOCKING GROUPS AND CLEAVABLE LINKERS

#19
20240239831
2024-07-18

METHODS OF PREPARING REDUCED NICOTINAMIDE RIBOSIDE AND DERIVATIVES THEREOF

#20
20240218007
2024-07-04

METHOD FOR INCREASING BULK DENSITY OF NICOTINAMIDE MONONUCLEOTIDE CRYSTAL AND CRYSTAL THEREOF

#21
20240116971
2024-04-11

NMN AND DERIVATIVES FOR ITS USE IN THE TREATMENT OF DEPRESSION AND/OR ANXIETY IN PATIENTS HAVING A FORM OF PARKINSONISM

#22
20240109932
2024-04-04

Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use

#23
20240101588
2024-03-28

Methods of preparing nicotinamide riboside and derivatives thereof

#24
20240034747
2024-02-01

RECRYSTALLIZATION METHOD FOR NMN PREPARATION

#25
20240010668
2024-01-11

3' PROTECTED NUCLEOTIDES

#26
20230416291
2023-12-28

HIGH-PURITY ß-NICOTINAMIDE MONONUCLEOTIDE (NMN) AND METHOD FOR PRODUCING SAME

#27
20230391815
2023-12-07

Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof

#28
20230348521
2023-11-02

METHODS OF SYNTHESIZING NICOTINAMIDE RIBOSIDE

#29
20230348520
2023-11-02

COMPOUND COMPRISING BETA-NICOTINAMIDE MONONUCLEOTIDE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF, AND METHOD FOR EVALUATING QUALITY AND METHOD FOR ASSESSING ENZYMATIC REACTIVITY OF SAID COMPOUND

#30
20230295211
2023-09-21

METHODS OF PRODUCING CRYSTALLINE BETA NICOTINAMIDE RIBOSIDE TRIACETATE CHLORIDE

#31
20230271995
2023-08-31

METHODS FOR PRODUCING DIHYDRONICOTINAMIDE RIBOSIDE FROM NICOTINAMIDE RIBOSIDE CHLORIDE

#32
20230257412
2023-08-17

Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use

#33
20230241225
2023-08-03

ANTI-VIRAL COMPOUNDS AND METHODS OF USE

#34
20230234981
2023-07-27

INORGANIC SALTS OF NICOTINIC ACID MONONUCLEOTIDE AS ANTI-AGING AGENTS

#35
20230158053
2023-05-25

Nicotinamide mononucleotide derivatives and their uses

#36
20230107185
2023-04-06

(Thio)nicotinamide ribofuranoside salts and compositions, methods of making, and uses thereof

#37
20220402961
2022-12-22

NICOTINAMIDE MONONUCLEOTIDE-ISONICOTINE COCRYSTAL AND COMPOSITION THEREOF

#38
20220363704
2022-11-17

Method for preparing nicotinamide mononucleotide by using nicotinamide as raw material

#39
20220348604
2022-11-03

3′ protected nucleotides

#40
20220324899
2022-10-13

COMPOUNDS AND COMPOSITIONS FOR DIFFERENTIAL MODULATION OF NICOTINAMIDE ADENINE DINUCLEOTIDE

#41
20220259250
2022-08-18

Methods of preparing reduced nicotinamide riboside and derivatives thereof

#42
20220251133
2022-08-11

Method of making nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts as such, and uses thereof

#43
20220204543
2022-06-30

Organic acid salt of nicotinamide riboside, composition including organic acid salt, and preparation methods of organic acid salt and composition

#44
20220144880
2022-05-12

Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide

#45
20220135610
2022-05-05

METHOD OF MAKING NICOTINAMIDE RIBOFURANOSIDE SALTS, NICOTINAMIDE RIBOFURANOSIDE SALTS AS SUCH, AND USES THEREOF

#46
20220106350
2022-04-07

Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof

#47
20220098229
2022-03-31

CRYSTAL FORMS OF BETA-NICOTINAMIDE MONONUCLEOTIDE

#48
20220089632
2022-03-24

Bicyclic nucleosides and oligomers prepared therefrom

#49
20220041642
2022-02-10

3′ protected nucleotides

#50
20210388019
2021-12-16

Anti-viral compounds and methods of use

#51
20210388018
2021-12-16

METHYL AND ETHYL NICOTINATE-RIBOSIDE-5-PHOSPHATES, PREPARATION THEREOF AND METHODS OF USE THEREOF

#52
20210371446
2021-12-02

SIRT1 activating compounds

#53
20210363168
2021-11-25

Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof

#54
20210355152
2021-11-18

Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives

#55
20210353657
2021-11-18

Nicotinoyl riboside compositions and methods of use

#56
20210347806
2021-11-11

Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof

#57
20210309686
2021-10-07

QUATERNARY AMMONIUM SALTS OF NICOTINIC ACID AND NICOTINAMIDE MONONUCLOETIDES AND RIBOSIDES AS ANTI-AGING AGENTS

#58
20210309685
2021-10-07

AMINO ACID SALTS OF NICOTINIC ACID MONONUCLEOTIDE AND NICOTINAMIDE MONONUCLOETIDE AS ANTI-AGEING AGENTS

#59
20210230208
2021-07-29

INORGANIC SALTS OF NICOTINAMIDE MONONUCLOETIDE AS ANTI-AGING AGENTS

#60
20210214386
2021-07-15

Beta-nicotinate ester nucleotides and processes for preparing same

#61
20210206793
2021-07-08

(Thio)nicotinamide ribofuranoside salts and compositions, methods of making, and uses thereof

#62
20210070798
2021-03-11

Inhibitors of E1 activating enzymes

#63
20210061841
2021-03-04

INORGANIC SALTS OF NICOTINIC ACID MONONUCLEOTIDE AS ANTI-AGING AGENTS

#64
20210032280
2021-02-04

Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof

#65
20210024565
2021-01-28

MODIFIED 2' AND 3'-NUCLEOSIDE PRODRUGS FOR TREATING FLAVIVIRIDAE INFECTIONS

#66
20200352966
2020-11-12

Nicotinamide mononucleotide derivatives and their uses

#67
20200332332
2020-10-22

Method for Producing Nicotinamide Mononucleotide and Transformant Used in Said Method

#68
20200291055
2020-09-17

Methods of preparing nicotinamide riboside and derivatives thereof

#69
20200289535
2020-09-17

Nicotinoyl riboside compositions and methods of use

#70
20200216487
2020-07-09

Efficient synthesis of nicotinamide mononucleotide

#71
20200181188
2020-06-11

Crystalline forms of nicotinoyl ribosides and derivatives thereof, and methods of preparation thereof

#72
20200157136
2020-05-21

Crystal forms of β-nicotinamide mononucleotide

#73
20200140475
2020-05-07

Methods of synthesizing nicotinamide riboside

#74
20200031860
2020-01-30

β-nicotinate ester nucleotides and process for preparing same

#75
20190382436
2019-12-19

Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives

#76
20190352325
2019-11-21

Inorganic salts of nicotinic acid mononucleotide as anti-aging agents

#77
20190345188
2019-11-14

Bicyclic nucleosides and oligomers prepared therefrom

#78
20190330155
2019-10-31

Kinase inhibitors

#79
20190315792
2019-10-17

MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES

#80
20190248827
2019-08-15

Design, synthesis and use of synthetic nucleotides comprising charge mass tags

#81
20190225641
2019-07-25

Crystal forms of beta-nicotinamide mononucleotide

#82
20190192542
2019-06-27

Nicotinoyl riboside compositions and methods of use

#83
20190085009
2019-03-21

Crystal forms of beta-nicotinamide mononucleotide

#84
20190085008
2019-03-21

Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases

#85
20190055275
2019-02-21

Process for preparation of nicotinamide riboside (NR) and cosmetic composition comprising (NR and a phosphate-binding agent

#86
20190004055
2019-01-03

Design, synthesis and use of synthetic nucleotides comprising charge mass tags

#87
20180362570
2018-12-20

Nicotinamide riboside derivatives and their uses

#88
20180353526
2018-12-13

Modulation of NAD+ metabolic pathways for treatment of disease

#89
20180334474
2018-11-22

Nicotinamide mononucleotide derivative and salt thereof, method for producing same, topical skin preparation, cosmetic and food additive

#90
20180319748
2018-11-08

Kinase inhibitors

#91
20180291054
2018-10-11

Efficient synthesis of nicotinamide mononucleotide

#92
20180282363
2018-10-04

GLUCOPYRANOSIDE COMPOUND

#93
20180282362
2018-10-04

Crystal forms of β-nicotinamide mononucleotide

#94
20180258127
2018-09-13

B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof

#95
20180237467
2018-08-23

MODIFIED 2' AND 3'-NUCLEOSIDE PRODRUGS FOR TREATING FLAVIVIRIDAE INFECTIONS

#96
20180208619
2018-07-26

Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives

#97
20180186824
2018-07-05

Methods of preparing nicotinamide riboside and derivatives thereof

#98
20180162895
2018-06-14

Method for preparing nicotinamide mononucleotide (NMN)

#99
20180147227
2018-05-31

Nicotinamide mononucleotide derivatives and their uses

#100
20180134743
2018-05-17

Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof

#101
20180134742
2018-05-17

Crystalline forms of nicotinoyl ribosides, modified derivatives thereof, and phosphorylated analogs thereof, and methods of preparation thereof

#102
20180086785
2018-03-29

SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES

#103
20180086783
2018-03-29

Crystalline form of nicotinamide riboside

#104
20180030079
2018-02-01

Crystalline form of nicotinamide riboside

#105
20170290850
2017-10-12

Nicotinamide mononucleotide derivatives and their uses

#106
20170267709
2017-09-21

B-vitamin and amino acid conjugates ofnicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof

#107
20170253563
2017-09-07

Kinase inhibitors

#108
20170210774
2017-07-27

Crystalline form of nicotinamide riboside

#109
20170204131
2017-07-20

Preparation and use of crystalline beta-D-nicotinamide riboside

#110
20170189434
2017-07-06

Nicotinamide mononucleotide derivatives and their uses

#111
20170189433
2017-07-06

Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof

#112
20170081428
2017-03-23

Immunomodulating beta-1,6-D-glucans

#113
20170029378
2017-02-02

Kinase inhibitor

#114
20160355539
2016-12-08

SELECTIVE SOLVENT FREE PHOSPHORYLATION

#115
20160333041
2016-11-17

Method for purifying beta-nicotinamide mononucleotide

#116
20160310517
2016-10-27

Nicotinoyl riboside compositions and methods of use

#117
20160272668
2016-09-22

Nicotinic acid riboside or nicotinamide riboside compositions, reduced derivatives thereof, and the use thereof to enhance skin permeation in treating skin conditions

#118
20160264614
2016-09-15

POLYNUCLEOTIDE MOLECULES AND USES THEREOF

#119
20160168184
2016-06-16

Methods of preparing nicotinamide riboside and derivatives thereof

#120
20160139133
2016-05-19

Design, synthesis and use of synthetic nucleotides comprising charge mass tags

#121
20160108078
2016-04-21

GLUCOPYRANOSIDE COMPOUND

#122
20160102059
2016-04-14

Kinase inhibitors

#123
20160096805
2016-04-07

Kinase inhibitor

#124
20150175645
2015-06-25

NICOTINAMIDE RIBOSIDE AND ANALOGUES THEREOF

#125
20150072950
2015-03-12

Nicotinoyl riboside compositions and methods of use

#126
20140294769
2014-10-02

2′,4′-fluoro nucleosides for the treatment of HCV

#127
20140256668
2014-09-11

SUBSTITUTED PYRROLO]2,3-D]PYRIMIDINES

#128
20140107058
2014-04-17

Pharmaceutical compositions comprising forms of 5-azacytidine

#129
20140057863
2014-02-27

Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation

#130
20140051846
2014-02-20

2′-O-aminooxymethyl nucleoside derivatives for use in the synthesis and modification of nucleosides, nucleotides and oligonucleotides

#131
20130338094
2013-12-19

SUBSTITUTED PYRROLO]2,3-D]PYRIMIDINES

#132
20130131001
2013-05-23

Epirubicin derivatives

#133
20130085272
2013-04-04

Way of using thermolabile groups to protect hydroxyl functions and compounds for implementing the procedure

#134
20130059810
2013-03-07

Pharmaceutical compositions comprising forms of 5-azacytidine

#135
20130059809
2013-03-07

Pharmaceutical compositions comprising forms of 5-azacytidine

#136
20120329748
2012-12-27

Activation and activators of SIRT5

#137
20120258913
2012-10-11

Glucopyranoside compound

#138
20120245335
2012-09-27

MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES

#139
20120172584
2012-07-05

Nicotyl riboside compositions and methods of use

#140
20120165514
2012-06-28

Synthesis of locked nucleic acid derivatives

#141
20120108535
2012-05-03

2-fluorinated riboses and arabinoses and methods of use and synthesis

#142
20120058941
2012-03-08

Glucopyranoside compound

#143
20110312905
2011-12-22

Stimulus-triggered prodrugs

#144
20110269707
2011-11-03

Modified nucleosides for the treatment of viral infections and abnormal cellullar proliferation

#145
20110136834
2011-06-09

INHIBITORS OF E1 ACTIVATING ENZYMES

#146
20110105424
2011-05-05

Glucopyranoside compound

#147
20110104108
2011-05-05

Methods of treating cancer and other conditions or disease states using LFMAU and LDT

#148
20110038833
2011-02-17

Modified fluorinated nucleoside analogues

#149
20100316594
2010-12-16

MODIFIED 2' AND 3' NUCLEOSIDE PRODRUGS FOR TREATING FLAVIVIRIDAE INFECTIONS

#150
20100298253
2010-11-25

Pharmaceutical compositions comprising 5-azacytidine monohydrate

#151
20100216983
2010-08-26

Synthesis of locked nucleic acid derivatives

#152
20100035835
2010-02-11

Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection

#153
20090221807
2009-09-03

2' Deoxy-2'-Alkylnucleotide Containing Nucleic Acid

#154
20090220950
2009-09-03

Simultaneous quantification of nucleic acids in diseased cells

#155
20090036666
2009-02-05

MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES

#156
20090004135
2009-01-01

MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES

#157
20080292687
2008-11-27

Methods of treating cancer and other conditions or disease states using LFMAU and LDT

#158
20080280850
2008-11-13

Methods and Compositions for Treating Flaviviruses, Pestiviruses and Hepacivirus

#159
20080253995
2008-10-16

MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES

#160
20080070861
2008-03-20

Modified fluorinated nucleoside analogues

#161
20070255045
2007-11-01

Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging

#162
20070203334
2007-08-30

Process for preparing a synthetic intermediate for preparation of branched nucleosides

#163
20070196824
2007-08-23

Kit for assessing mitochondrial toxicity

#164
20070117765
2007-05-24

Nicotinoyl riboside compositions and methods of use

#165
20070087960
2007-04-19

Modified 2′ and 3′-nucleoside prodrugs for treating infections

#166
20070077198
2007-04-05

Method for preparing radiolabeled thymidine having low chromophoric byproducts

#167
20070042991
2007-02-22

Modified 2′ and 3′-nucleoside prodrugs for treating infections

#168
20070042940
2007-02-22

Modified 2′ and 3′-nucleoside prodrugs for treating infections

#169
20070042939
2007-02-22

Modified 2′ and 3′-nucleoside prodrugs for treating infections

#170
20070037771
2007-02-15

Process for preparing branched ribonucleosides from 1,2-anhydroribofuranose intermediates

#171
20070032449
2007-02-08

Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae infections

#172
20070032407
2007-02-08

Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections

#173
20070031824
2007-02-08

Simultaneous quantification of nucleic acids in diseased cells

#174
20070027104
2007-02-01

Modified 2' and 3'-nucleoside prodrugs for treating Flaviviridae infections

#175
20070027066
2007-02-01

Modified 2′ and 3′-nucleoside prodrugs for treating infections

#176
20070027065
2007-02-01

Modified 2' and 3'-nucleoside prodrugs for treating Flaviviridae infections

#177
20060293510
2006-12-28

Metal complex type nucleic acid

#178
20060276638
2006-12-07

Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonate and use thereof for making a beta nucleoside

#179
20060263293
2006-11-23

Click chemistry method for synthesizing molecular imaging probes

#180
20060247189
2006-11-02

Forms of 5-azacytidine

#181
20060242770
2006-11-02

Xyloglucan conjugates useful for modifying cellulosic textiles

#182
20060229265
2006-10-12

Nicotinamide riboside and analogues thereof

#183
20060205687
2006-09-14

Azacytosine analogs and derivatives

#184
20060205685
2006-09-14

Azacytosine analogs and derivatives

#185
20060189636
2006-08-24

Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of E1 activating enzymes

#186
20060173174
2006-08-03

Difluoronucleosides and process for preparation thereof

#187
20060142557
2006-06-29

2'-deoxy-2'alkylnucleotide containing nucleic acid

#188
20060094670
2006-05-04

Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases

#189
20060089318
2006-04-27

Inhibitors of adp-ribosyl transferases, cyclases, and hydrolases

#190
20050233988
2005-10-20

Glucopyranoside compound

#191
20050222056
2005-10-06

Heterocyclic compounds and their use in the detection of nucleic acids

#192
20050137150
2005-06-23

Forms of 5-Azacytidine

#193
20050131223
2005-06-16

Method for preparing radiolabeled thymidine having low chromophoric byproducts

#194
20050069495
2005-03-31

Cancer specific radiolabeled conjugates regulated by the cell cycle for the treatment and diagnosis of cancer

#195
20050009737
2005-01-13

Modified fluorinated nucleoside analogues

#196
17323789
2022-02-08

Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof

#197
16362130
2020-04-14

Compositions and methods for modulation of nicotinamide adenine dinucleotide

#198
16160189
2021-11-09

Synthesis and stabilization of nicotinamide ribose and its derivatives