ClassID:

97069

C07K14/755 - CPC Classification

Classification description:

Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans; Blood coagulation or fibrinolysis factors Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Recent Application in this class:
#1
20260152761
2026-06-04

GENE THERAPY FOR TREATING WILSON'S DISEASE

#2
20260152576
2026-06-04

HETERODIMERIC HUMAN IgG1 POLYPEPTIDES WITH ISOELECTRIC POINT MODIFICATIONS

#3
20260137760
2026-05-21

FACTOR VIII POLYPEPTIDE FORMULATIONS

#4
20260091138
2026-04-02

VARIANTS OF COAGULATION FACTOR VIII AND USES THEREOF

#5
20260085132
2026-03-26

HETERODIMERIC HUMAN IgG1 POLYPEPTIDES WITH ISOELECTRIC POINT MODIFICATIONS

#6
20260049115
2026-02-19

METHODS AND COMPOSITIONS FOR TREATING CANCER WITH ECM-AFFINITY PEPTIDES LINKED TO CYTOKINES

#7
20260035485
2026-02-05

HETERODIMERIC HUMAN IgG1 POLYPEPTIDES WITH ISOELECTRIC POINT MODIFICATIONS

#8
20260028429
2026-01-29

HETERODIMERIC HUMAN IgG1 POLYPEPTIDES WITH ISOELECTRIC POINT MODIFICATIONS

#9
20260028386
2026-01-29

COMPOSITIONS AND METHODS OF CHIMERIC ALLOANTIGEN RECEPTOR T CELLS

#10
20260000721
2026-01-01

MEANS AND METHODS FOR AAV GENE THERAPY IN HUMANS

#11
20250340588
2025-11-06

PLASMA FRACTIONATION UTILIZING SPRAY-DRIED HUMAN PLASMA

#12
20250332224
2025-10-30

Adeno-Associated Virus Factor VIII Vectors

#13
20250325706
2025-10-23

LINKER PEPTIDE, FVIII PROTEIN OR VARIANT THEREOF CONTAINING LINKER PEPTIDE, AND USE THEREOF

#14
20250289869
2025-09-18

FACTOR VIII CHIMERIC PROTEINS AND USES THEREOF

#15
20250282848
2025-09-11

NON-VIRAL DNA VECTORS AND USES THEREOF FOR EXPRESSING FVIII THERAPEUTICS

#16
20250282847
2025-09-11

CODON-OPTIMIZED NUCLEIC ACID ENCODING THE FVIII-BDD

#17
20250276093
2025-09-04

THERAPEUTIC ADENO-ASSOCIATED VIRUS USING CODON OPTIMIZED NUCLEIC ACID ENCODING FACTOR VIII

#18
20250269067
2025-08-28

NUCLEIC ACID MOLECULES AND USES THEREOF FOR NON-VIRAL GENE THERAPY

#19
20250250322
2025-08-07

COMPOSITIONS AND METHODS FOR MODULATING FACTOR VIII FUNCTION

#20
20250235409
2025-07-24

IMPLANTABLE PARTICLES AND RELATED METHODS

#21
20250230466
2025-07-17

TISSUE-SPECIFIC PROMOTER AND USE THEREOF

#22
20250230262
2025-07-17

HETERODIMERIC HUMAN IgG1 POLYPEPTIDES WITH ISOELECTRIC POINT MODIFICATIONS

#23
20250228964
2025-07-17

PREPARATION OF THERAPEUTIC EXOSOMES USING MEMBRANE PROTEINS

#24
20250195620
2025-06-19

FACTOR VIII CHIMERIC AND HYBRID POLYPEPTIDES, AND METHODS OF USE THEREOF

#25
20250186598
2025-06-12

RECOMBINANT HUMAN SERUM ALBUMIN-COLLAGEN BINDING DOMAIN FUSION PROTEIN FOR TUMOR-SPECIFIC TARGETING MATRIX, AND USE THEREOF

#26
20250171805
2025-05-29

NUCLEIC ACID MOLECULES AND USES THEREOF

#27
20250171521
2025-05-29

CpG REDUCED FACTOR VIII VARIANTS, COMPOSITIONS AND METHODS AND USES FOR TREATMENT OF HEMOSTASIS DISORDERS

#28
20250136640
2025-05-01

ON-COLUMN VIRAL INACTIVATION METHODS

#29
20250121096
2025-04-17

ENGINEERED LIVER-SPECIFIC ENHANCERS AND THEIR APPLICATIONS

#30
20250109185
2025-04-03

OPTIMIZED HUMAN CLOTTING FACTOR VIII GENE EXPRESSION CASSETTES AND THEIR USE

#31
20250108093
2025-04-03

Factor VIII Sequences

#32
20250101465
2025-03-27

ADENO-ASSOCIATED VIRUS COMPOSITIONS AND METHODS OF USE THEREOF

#33
20250092117
2025-03-20

METHODS OF TREATING HEMOPHILIA A

#34
20250073313
2025-03-06

HIGHLY SOLUBLE FIBRINOGEN COMPOSITIONS

#35
20250049961
2025-02-13

SCALABLE AND HIGH-PURITY CELL-FREE SYNTHESIS OF CLOSED-ENDED DNA VECTORS

#36
20250043310
2025-02-06

GENE THERAPY OF HEMOPHILIA A USING VIRAL VECTORS ENCODING RECOMBINANT FVIII VARIANTS WITH INCREASED EXPRESSION

#37
20250034232
2025-01-30

von Willebrand Factor Proteins for Treating Bleeding Disorders

#38
20250027065
2025-01-23

ENGINEERED NUCLEASES THAT TARGET HUMAN AND CANINE FACTOR VIII GENES AS A TREATMENT FOR HEMOPHILIA A

#39
20250019417
2025-01-16

NOVEL POLYPEPTIDES AND MEDICAL USES THEREOF

#40
20240400645
2024-12-05

METHODS OF TREATING HEMOPHILIA A

#41
20240398990
2024-12-05

LIVER-SPECIFIC EXPRESSION CASSETTES, VECTORS AND USES THEREOF FOR EXPRESSING THERAPEUTIC PROTEINS

#42
20240350672
2024-10-24

NUCLEIC ACIDS ENCODING FACTOR VIII POLYPEPTIDES WITH REDUCED IMMUNOGENICITY

#43
20240350671
2024-10-24

ENGINEERED ITR SEQUENCES AND METHODS OF USE

#44
20240335564
2024-10-10

ISOLATED NUCLEIC ACID MOLECULE AND USE THEREOF

#45
20240287158
2024-08-29

FORMULATIONS OF FACTOR VIII CHIMERIC PROTEINS AND USES THEREOF

#46
20240270822
2024-08-15

PLATELET TARGETED TREATMENT

#47
20240254197
2024-08-01

Engineered Human FVIII with Enhanced Secretion Ability and Clotting Activity

#48
20240218048
2024-07-04

RECOMBINANT COAGULATION FACTOR VIII AND USE THEREOF

#49
20240212861
2024-06-27

POPULATION PHARMACOKINETICS TOOLS AND USES THEREOF

#50
20240209393
2024-06-27

SYNTHETIC AAV VECTORS FOR REPEATED DELIVERY OF THERAPEUTIC GENES

#51
20240207379
2024-06-27

STRATEGIES TO PREVENT AND/OR TREAT IMMUNE RESPONSES TO SOLUBLE ALLOFACTORS

#52
20240173434
2024-05-30

COMPOSITIONS AND METHODS FOR GENE EDITING FOR HEMOPHILIA A

#53
20240166722
2024-05-23

MODIFIED PLASMA CLOTTING FACTOR VIII AND METHOD OF USE THEREOF

#54
20240141019
2024-05-02

OPTIMIZED FACTOR VIII GENE

#55
20240124555
2024-04-18

OPTIMIZED FACTOR VIII GENES

#56
20240108743
2024-04-04

LINKER PEPTIDE FOR CONSTRUCTING FUSION PROTEIN

#57
20240083975
2024-03-14

THROMBIN CLEAVABLE LINKER WITH XTEN AND ITS USES THEREOF

#58
20240066067
2024-02-29

IN UTERO TRANSPLANTATION OF FACTOR VIII-EXPRESSING CELLS FOR TREATMENT OF HEMOPHILIA

#59
20240058423
2024-02-22

Adeno-Associated Virus Factor VIII Vectors, Associated Viral Particles and Therapeutic Formulations Comprising the Same

#60
20240052012
2024-02-15

PLATELET ALPHA-GRANULES FOR DELIVERY OF MULTIPLE PROTEINS

#61
20240043500
2024-02-08

Polypeptides and medical uses thereof

#62
20240010707
2024-01-11

De-immunized factor VIII molecule and pharmaceutical compositions comprising the same

#63
20240009322
2024-01-11

Preparation of therapeutic exosomes using membrane proteins

#64
20230392126
2023-12-07

TISSUE ORGANOIDS

#65
20230383311
2023-11-30

NON-VIRAL DNA VECTORS AND USES THEREOF FOR EXPRESSING FVIII THERAPEUTICS

#66
20230377764
2023-11-23

METHODS AND COMPOSITIONS FOR TREATING CANCER WITH ECM-AFFINITY PEPTIDES LINKED TO IMMUNOTHERAPEUTIC ANTIBODIES

#67
20230365655
2023-11-16

COMPOUND FOR INCREASING THE EFFICACY OF FACTOR VIII REPLACEMENT THERAPY

#68
20230357360
2023-11-09

NUCLEIC ACID AND AMINO ACID SEQUENCES ENCODING HIGH-LEVEL EXPRESSOR FACTOR VIII POLYPEPTIDES AND METHODS OF USE

#69
20230340073
2023-10-26

RECOMBINANT FACTOR VIII VARIANTS

#70
20230331774
2023-10-19

On-column viral inactivation methods

#71
20230322901
2023-10-12

RECOMBINANT FACTOR VIII PROTEINS

#72
20230322900
2023-10-12

FACTOR VIII COMPOSITIONS AND METHODS OF MAKING AND USING SAME

#73
20230313224
2023-10-05

INTEGRATION OF LARGE ADENOVIRUS PAYLOADS

#74
20230279072
2023-09-07

REGULATORY T CELL EPITOPES

#75
20230241180
2023-08-03

Factor VIII Sequences

#76
20230203195
2023-06-29

ANTI-VWF D'D3 SINGLE-DOMAIN ANTIBODIES AND POLYPEPTIDES COMPRISING THEREOF

#77
20230190881
2023-06-22

SUBCUTANEOUS ADMINISTRATION OF FACTOR VIII

#78
20230173081
2023-06-08

Factor VIII zwitterionic polymer conjugates

#79
20230159620
2023-05-25

COMPOSITIONS AND METHODS OF TREATMENT FOR VASCULAR DISEASES AND THROMBOSIS

#80
20230151078
2023-05-18

RECOMBINANT SINGLE-CHAIN FVIII AND CHEMICAL CONJUGATE THEREOF

#81
20230134182
2023-05-04

METHOD FOR EFFICIENTLY SEPARATING AND PURIFYING RECOMBINANT HUMAN COAGULATE FACTOR VIII FC FUSION PROTEIN

#82
20230119850
2023-04-20

LIVER-SPECIFIC CONSTRUCTS, FACTOR VIII EXPRESSION CASSETTES AND METHODS OF USE THEREOF

#83
20230091932
2023-03-23

CLOSED-END DNA PRODUCTION WITH INVERTED TERMINAL REPEAT SEQUENCES

#84
20230091082
2023-03-23

Chromatographic methods for purification of proteins from plasma

#85
20230084036
2023-03-16

OPTIMIZED FACTOR VIII GENES

#86
20230048492
2023-02-16

Adeno-Associated Viral (AAV) Vectors for Tissue-Targeted Expression of Therapeutic Genes

#87
20230045478
2023-02-09

LIVER-SPECIFIC PROMOTER AND APPLICATION THEREOF

#88
20230023927
2023-01-26

IMMUNOGLOBULIN CHIMERIC MONOMER-DIMER HYBRIDS

#89
20230019286
2023-01-19

FACTOR VIII COMPOSITIONS AND METHODS OF MAKING AND USING SAME

#90
20230017907
2023-01-19

METHOD FOR CONTINUOUS PROTEIN RECOVERING

#91
20230011438
2023-01-12

CHIMERIC FACTOR VIII POLYPEPTIDES AND USES THEREOF

#92
20230002828
2023-01-05

METHODS OF REDUCING IMMUNOGENICITY AGAINST FACTOR VIII IN INDIVIDUALS UNDERGOING FACTOR VIII THERAPY

#93
20220411795
2022-12-29

ENGINEERED CELLS FOR CONTROLLED PRODUCTION

#94
20220403005
2022-12-22

COMPOSITIONS AND METHODS FOR MODULATING FACTOR VIII FUNCTION

#95
20220396611
2022-12-15

FACTOR VIII CONSTRUCT

#96
20220396610
2022-12-15

FACTOR VIII POLYPEPTIDE

#97
20220395545
2022-12-15

Means and methods for AAV gene therapy in humans

#98
20220389455
2022-12-08

GENE THERAPY FOR TREATING WILSON'S DISEASE

#99
20220389082
2022-12-08

A TRUNCATED VON WILLEBRAND FACTOR (VWF) FOR INCREASING THE IN VITRO STABILITY OF COAGULATION FACTOR VIII

#100
20220362408
2022-11-17

Optimized promoter sequences, intron-free expression constructs and methods of use

#101
20220348637
2022-11-03

POLYPEPTIDES FOR INDUCING TOLERANCE TO FACTOR VIII

#102
20220339262
2022-10-27

Adeno-associated virus factor VIII vectors

#103
20220333135
2022-10-20

Gene therapy of hemophilia a using viral vectors encoding recombinant FVIII variants with increased expression

#104
20220315643
2022-10-06

Modified plasma clotting factor VIII and method of use thereof

#105
20220306684
2022-09-29

Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications

#106
20220275058
2022-09-01

Purification of Factor VIII subspecies

#107
20220275057
2022-09-01

FACTOR VIII CHIMERIC PROTEINS AND USES THEREOF

#108
20220265780
2022-08-25

FACTOR VIII-FC CHIMERIC AND HYBRID POLYPEPTIDES, AND METHODS OF USE THEREOF

#109
20220259287
2022-08-18

SINGLE CHAIN FACTOR VIII MOLECULE

#110
20220243201
2022-08-04

ENGINEERED ITR SEQUENCES AND METHODS OF USE

#111
20220220488
2022-07-14

SYNTHETIC PRODUCTION OF SINGLE-STRANDED ADENO ASSOCIATED VIRAL DNA VECTORS

#112
20220220188
2022-07-14

COMPOSITIONS AND METHODS OF CHIMERIC ALLOANTIGEN RECEPTOR T CELLS

#113
20220213200
2022-07-07

ANTI-GPIIB/IIIA ANTIBODIES OR USES THEREOF

#114
20220213172
2022-07-07

VIRAL VECTORS ENCODING RECOMBINANT FVIII VARIANTS WITH INCREASED EXPRESSION FOR GENE THERAPY OF HEMOPHILIA A

#115
20220204555
2022-06-30

METHOD FOR PURIFICATION OF PLASMA PROTEINS

#116
20220193267
2022-06-23

ENGINEERED NUCLEASES USEFUL FOR TREATMENT OF HEMOPHILIA A

#117
20220177545
2022-06-09

NON-VIRAL DNA VECTORS AND USES THEREOF FOR EXPRESSING FVIII THERAPEUTICS

#118
20220169712
2022-06-02

METHOD FOR REDUCING THE IMMUNE RESPONSE TO A BIOLOGICALLY ACTIVE PROTEIN

#119
20220144919
2022-05-12

MUTANT FACTOR VIII COMPOSITIONS AND METHODS

#120
20220106383
2022-04-07

THROMBIN CLEAVABLE LINKER WITH XTEN AND ITS USES THEREOF

#121
20220106357
2022-04-07

PLASMA FRACTIONATION UTILIZING SPRAY-DRIED HUMAN PLASMA

#122
20220105193
2022-04-07

Linker peptide for constructing fusion protein

#123
20220090130
2022-03-24

MODIFIED BACULOVIRUS SYSTEM FOR IMPROVED PRODUCTION OF CLOSED-ENDED DNA (ceDNA)

#124
20220089685
2022-03-24

RED BLOOD CELL TARGETED FACTOR VIII AND METHOD OF USING THE SAME

#125
20220080055
2022-03-17

COMPOSITIONS AND METHODS FOR GENE EDITING FOR HEMOPHILIA A

#126
20220056108
2022-02-24

FACTOR VIII COMPLEX WITH XTEN AND VON WILLEBRAND FACTOR PROTEIN, AND USES THEREOF

#127
20220041693
2022-02-10

SEPARATION OF VWF AND VWF PROPEPTIDE BY CHROMATOGRAPHIC METHODS

#128
20220033476
2022-02-03

FUSION PROTEIN OF MUTATED SINGLE-CHAIN HUMAN COAGULATION FACTOR VIII, PREPARATION METHOD THEREFOR, AND USE THEREOF

#129
20220033475
2022-02-03

Compositions and methods for modulating Factor VIII function

#130
20220033474
2022-02-03

STRUCTURE-SENSITIVE PEPTIDE ANTIGEN OF VON WILLEBRAND FACTOR

#131
20220025399
2022-01-27

Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor

#132
20220017586
2022-01-20

EXPOSED COLLAGEN-TARGETED FUSION CYTOKINE FOR IMMUNE MODULATION IN INVASIVE CANCERS AND LESIONS OF INFECTIONS

#133
20220010000
2022-01-13

IMMUNOGLOBULIN CHIMERIC MONOMER-DIMER HYBRIDS

#134
20210405064
2021-12-30

BI-FUNCTIONAL ARGININE-GLYCINE-ASPARTIC ACID (RGD) PEPTIDES AND METHODS TO PROMOTE ANGIOGENESIS

#135
20210403535
2021-12-30

Polypeptides and medical uses thereof

#136
20210388055
2021-12-16

Factor VIII proteins having ancestral sequences, expression vectors, and uses related thereto

#137
20210379203
2021-12-09

New Tools for Improving Gene Therapy and Use Thereof

#138
20210369868
2021-12-02

Optimized Liver-Specific Expression Systems for FVIII and FIX

#139
20210355473
2021-11-18

CHIMERIC CLOTTING FACTORS

#140
20210355162
2021-11-18

MODULATION OF ANTIGEN IMMUNOGENICITY BY DELETING EPITOPES RECOGNIZED BY NKT CELLS

#141
20210348190
2021-11-11

ADENO-ASSOCIATED VIRUS (AAV) SEROTYPE 8 SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR

#142
20210348159
2021-11-11

COMPOSITIONS AND METHODS FOR DELIVERING TRANSGENES

#143
20210346476
2021-11-11

Modified FVIII Apitope Peptides

#144
20210332335
2021-10-28

In vivo protein N-acylation

#145
20210308229
2021-10-07

Method for improving the stability of purified Factor VIII after reconstitution

#146
20210300985
2021-09-30

REGULATORY T CELL EPITOPES

#147
20210292729
2021-09-23

PROCESSABLE SINGLE CHAIN MOLECULES AND POLYPEPTIDES MADE USING SAME

#148
20210284754
2021-09-16

HETERODIMERIC HUMAN IgG1 POLYPEPTIDES WITH ISOELECTRIC POINT MODIFICATIONS

#149
20210284715
2021-09-16

COAGULATION FACTOR VIII MIMETIC PROTEIN AND USES THEREOF

#150
20210283530
2021-09-16

METHOD OF PURIFYING THERAPEUTIC PROTEINS

#151
20210275644
2021-09-09

Polypeptides modulating SIGLEC dependent immune responses

#152
20210261607
2021-08-26

PURIFICATION OF CHIMERIC FVIII MOLECULES

#153
20210220476
2021-07-22

Factor VIII chimeric and hybrid polypeptides, and methods of use thereof

#154
20210187125
2021-06-24

COMPOSITIONS AND METHODS FOR GENE EDITING FOR HEMOPHILIA A

#155
20210163986
2021-06-03

Nucleic acid molecules and uses thereof

#156
20210163575
2021-06-03

FACTOR VIII MUTANT EXPRESSION VECTOR WITH ENHANCED PROTEIN EXPRESSION

#157
20210163527
2021-06-03

NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE

#158
20210145759
2021-05-20

Implantable particles and related methods

#159
20210130824
2021-05-06

COMPOSITIONS AND METHODS FOR GENE EDITING BY TARGETING FIBRINOGEN-ALPHA

#160
20210130413
2021-05-06

MODIFIED AAV CAPSIDS AND USES THEREOF

#161
20210128751
2021-05-06

RECOMBINANT PROMOTERS AND VECTORS FOR PROTEIN EXPRESSION IN LIVER AND USE THEREOF

#162
20210121535
2021-04-29

Methods for preparing modified von Willebrand Factor

#163
20210115110
2021-04-22

Method of producing recombinant high molecular weight vWF in cell culture

#164
20210094995
2021-04-01

METHODS AND COMPOSITIONS FOR TREATING CANCER WITH ECM-AFFINITY PEPTIDES LINKED TO CYTOKINES

#165
20210079062
2021-03-18

IN-VIVO RELEASE SUSTAINED RECOMBINANT COAGULATION FACTOR VIII AND PREPARATION METHOD THEREFOR

#166
20210069300
2021-03-11

FACTOR VIII POLYPEPTIDE FORMULATIONS

#167
20210052740
2021-02-25

Nucleic acids encoding clotting factor variants and their use

#168
20210000978
2021-01-07

Optimised coding sequence and promoter

#169
20200392207
2020-12-17

Polypeptides and medical uses thereof

#170
20200392205
2020-12-17

MUTEINS OF CLOTTING FACTOR Vlll

#171
20200390866
2020-12-17

Factor VIII sequences

#172
20200370019
2020-11-26

RECOMBINANT ADIPOSE-DERIVED STEM CELL EXPRESSING BDDHFVIII GENE, AND PREPARATION METHOD AND APPLICATION THEREOF

#173
20200368327
2020-11-26

Methods for preparing modified von Willebrand factor

#174
20200368286
2020-11-26

IN UTERO TRANSPLANTATION OF FACTOR VIII-EXPRESSING CELLS FOR TREATMENT OF HEMOPHILIA

#175
20200360441
2020-11-19

POST-NATAL TRANSPLANTATION OF FACTOR VIII-EXPRESSING CELLS FOR TREATMENT OF HEMOPHILIA

#176
20200347116
2020-11-05

Von Willebrand factor proteins for treating bleeding disorders

#177
20200331985
2020-10-22

Force sensor cleavage domain containing chimeric polypeptides and methods of use thereof

#178
20200331984
2020-10-22

HARNESSING PROTEIN-BASED DRUGS COMPRISING AN ANCHOR DOMAIN FOR USE ON THE OCULAR SURFACE

#179
20200291102
2020-09-17

METHOD FOR REDUCING THE IMMUNE RESPONSE TO A BIOLOGICALLY ACTIVE PROTEIN

#180
20200291092
2020-09-17

Treatment of monogenetic disorders

#181
20200289672
2020-09-17

Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A

#182
20200289624
2020-09-17

METHODS AND COMPOSITIONS RELATED TO LONG HALF-LIFE COAGULATION COMPLEXES

#183
20200283799
2020-09-10

ADENO-ASSOCIATED VIRUS (AAV) SEROTYPE 8 SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR

#184
20200283474
2020-09-10

On-column viral inactivation methods

#185
20200277401
2020-09-03

Anti-coagulation factor VIII antibody and use thereof

#186
20200277356
2020-09-03

Factor VIII proteins having ancestral sequences, expression vectors, and uses related thereto

#187
20200270313
2020-08-27

COMPOSITIONS AND METHODS FOR SUPPRESSION OF INHIBITOR FORMATION AGAINST COAGULATION FACTORS IN HEMOPHILIA PATIENTS

#188
20200268854
2020-08-27

Method for improving the stability of purified Factor VIII after reconstitution

#189
20200263204
2020-08-20

COMPOSITION FOR TREATING HEMOPHILIA A BY CRISPR/CAS SYSTEM OF REVERTING FVIII GENE INVERSION

#190
20200263196
2020-08-20

METHODS, COMPOSITIONS, AND IMPLANTABLE ELEMENTS COMPRISING ACTIVE CELLS

#191
20200261590
2020-08-20

Factor VIII zwitterionic polymer conjugates

#192
20200222556
2020-07-16

Preparation of therapeutic exosomes using membrane proteins

#193
20200207869
2020-07-02

Anti-VWF D'D3 single-domain antibodies fuse to clotting factors

#194
20200199176
2020-06-25

METHOD FOR VIRUS FILTRATION OF VON WILLEBRAND FACTOR

#195
20200179499
2020-06-11

STRATEGIES TO PREVENT AND/OR TREAT IMMUNE RESPONSES TO SOLUBLE ALLOFACTORS

#196
20200165631
2020-05-28

ENDOTHELIAL-SPECIFIC PROMOTER SEQUENCES AND USES THEREOF

#197
20200157186
2020-05-21

Truncated VWF

#198
20200131482
2020-04-30

TISSUE ORGANOIDS

#199
20200123228
2020-04-23

Methods of treating cancer with placenta growth factor peptide linked to immunotherapeutic antibodies

#200
20200102391
2020-04-02

ANTI-GPIIB/IIIA ANTIBODIES OR USES THEREOF

#201
20200101140
2020-04-02

Adeno-associated virus factor VIII vectors

#202
20200095567
2020-03-26

PROTEOLYTICALLY CLEAVABLE FUSION PROTEINS WITH HIGH MOLAR SPECIFIC ACTIVITY

#203
20200087379
2020-03-19

FACTOR VIII COMPOSITIONS AND METHODS OF MAKING AND USING SAME

#204
20200071385
2020-03-05

Immunoglobulin chimeric monomer-dimer hybrids

#205
20200069817
2020-03-05

NUCLEIC ACID MOLECULES AND USES THEREOF FOR NON-VIRAL GENE THERAPY

#206
20200063111
2020-02-27

In vivo protein N-acylation

#207
20200061161
2020-02-27

Adeno-associated virus Factor VIII vectors, associated viral particles and therapeutic formulations comprising the same

#208
20200048327
2020-02-13

Recombinant factor VIII proteins

#209
20200024327
2020-01-23

Optimized factor VIII gene

#210
20200017543
2020-01-16

NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE

#211
20200010532
2020-01-09

Method of separating Factor VIII from blood products

#212
20190382467
2019-12-19

Separation of VWF and VWF propeptide by chromatographic methods

#213
20190375822
2019-12-12

Methods of treating hemophilia A

#214
20190365867
2019-12-05

Highly glycosylated human blood-clotting factor VIII fusion protein, and manufacturing method and application of same

#215
20190362856
2019-11-28

POPULATION PHARMACOKINETICS TOOLS AND USES THEREOF

#216
20190359687
2019-11-28

Red blood cell targeted factor VIII and method of using the same

#217
20190351073
2019-11-21

Factor VIII mutation repair and tolerance induction

#218
20190338310
2019-11-07

Gene therapy for treating Wilson's disease

#219
20190330311
2019-10-31

Chimera protein comprising FVIII and vWF factors, and use thereof

#220
20190315835
2019-10-17

FACTOR VIII COMPOSITIONS AND METHODS OF MAKING AND USING SAME

#221
20190314516
2019-10-17

Blood coagulation protein conjugates

#222
20190309048
2019-10-10

Optimized human clotting factor VIII gene expression cassettes and their use

#223
20190307854
2019-10-10

Allelic variants of human factor VIII

#224
20190292563
2019-09-26

Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor

#225
20190284576
2019-09-19

SCALABLE HIGH RECOVERY METHODS FOR PRODUCING HIGH YIELD RECOMBINANT ADENO-ASSOCIATED VIRAL (rAAV) VECTOR AND RECOMBINANT ADENO-ASSOCIATED VIRAL (rAAV) VECTORS PRODUCED THEREBY

#226
20190270791
2019-09-05

PLATELET TARGETED TREATMENT

#227
20190269796
2019-09-05

Promoter for cell-specific gene expression and uses thereof

#228
20190263890
2019-08-29

Truncated von Willebrand Factor polypeptides for treating hemophilia

#229
20190262429
2019-08-29

Factor VIII-FC chimeric and hybrid polypeptides, and methods of use thereof

#230
20190241960
2019-08-08

Methods of reducing immunogenicity against factor VIII in individuals undergoing factor VIII therapy

#231
20190241925
2019-08-08

Cell-associated secretion-enhancing fusion proteins

#232
20190225648
2019-07-25

Biologically active peptides

#233
20190216723
2019-07-18

Protein stabilizing factors

#234
20190209948
2019-07-11

Hydrophobic charge induction chromatographic protein depleted solution

#235
20190202893
2019-07-04

Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A

#236
20190201495
2019-07-04

Polypeptides modulating SIGLEC dependent immune responses

#237
20190194679
2019-06-27

Codon optimization for increasing transgene expression in chloroplasts of higher seed plants

#238
20190194602
2019-06-27

Mammalian cell culture-produced neublastin antibodies

#239
20190194295
2019-06-27

Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A

#240
20190194265
2019-06-27

Compositions and methods for suppression of inhibitor formation against coagulation factors in hemophilia patients

#241
20190185905
2019-06-20

Polypeptide substrate for the detection of von Williebrand factor cleaving protease ADAMTS13

#242
20190185543
2019-06-20

Optimized factor VIII genes

#243
20190184026
2019-06-20

Linker peptide for constructing fusion protein

#244
20190177399
2019-06-13

Mutant factor VIII compositions and methods

#245
20190169268
2019-06-06

Glycosylated VWF fusion proteins with improved pharmacokinetics

#246
20190169267
2019-06-06

Factor VIII complex with XTEN and von Willebrand Factor protein, and uses thereof

#247
20190153064
2019-05-23

COMPOSITIONS AND METHODS OF CHIMERIC ALLOANTIGEN RECEPTOR T CELLS

#248
20190151472
2019-05-23

Liver-specific constructs factor VIII expression cassettes and methods of use thereof

#249
20190144524
2019-05-16

FACTOR VIII VARIANTS, NUCLEIC ACID SEQUENCES, AND METHODS AND USES FOR TREATMENT OF HEMOSTASIS DISORDERS

#250
20190142973
2019-05-16

Engineered nucleases useful for treatment of hemophilia A

#251
20190142970
2019-05-16

Liver-specific constructs and methods of use thereof

#252
20190117792
2019-04-25

Preparation of therapeutic exosomes using membrane proteins

#253
20190085096
2019-03-21

Anti-VWF D'D3 single-domain antibodies and methods of use

#254
20190085052
2019-03-21

Method of producing recombinant high molecular weight vWF in cell culture

#255
20190062403
2019-02-28

Purification of factor VIII subspecies

#256
20190060483
2019-02-28

Preparation of therapeutic exosomes using membrane proteins

#257
20190048362
2019-02-14

Production of oversized adeno-associated vectors

#258
20190038722
2019-02-07

Method for improving the stability of purified factor VIII after reconstitution

#259
20190030169
2019-01-31

STABILIZING AGENT FOR PHARMACEUTICAL PROTEINS

#260
20190023767
2019-01-24

Polypeptides and medical uses thereof

#261
20190017068
2019-01-17

Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor

#262
20190016784
2019-01-17

Mutated von Willebrand factor

#263
20190015483
2019-01-17

Mutated truncated von Willebrand Factor

#264
20190010212
2019-01-10

CELL LINE EXPRESSING SINGLE CHAIN FACTOR VIII POLYPEPTIDES AND USES THEREOF

#265
20190008909
2019-01-10

Means and methods for AAV gene therapy in humans

#266
20180360982
2018-12-20

Factor VIII chimeric and hybrid polypeptides, and methods of use thereof

#267
20180344877
2018-12-06

Recombinant promoters and vectors for protein expression in liver and use thereof

#268
20180334491
2018-11-22

Variant serum albumin with improved half-life and other properties

#269
20180327479
2018-11-15

Factor VIII variants having a decreased cellular uptake

#270
20180327478
2018-11-15

Method for the production of freeze-dried pellets comprising factor VIII

#271
20180320159
2018-11-08

Processable single chain molecules and polypeptides made using same

#272
20180312571
2018-11-01

CpG REDUCED FACTOR VIII VARIANTS, COMPOSITIONS AND METHODS AND USES FOR TREATMENT OF HEMOSTASIS DISORDERS

#273
20180311317
2018-11-01

Method of treating hemophilia A

#274
20180305695
2018-10-25

DNA aptamer that binds to vWF

#275
20180273607
2018-09-27

MODIFIED BLOOD CLOTTING FACTORS AND METHODS OF USE

#276
20180228872
2018-08-16

Methods and compositions related to long half-life coagulation complexes

#277
20180222959
2018-08-09

Exposed collagen-targeted fusion cytokine for immune modulation in invasive cancers and lesions of infections

#278
20180201685
2018-07-19

METHODS FOR USE OF MIXED MULTIFUNCTIONAL SURFACES FOR REDUCING AGGREGATE CONTENT IN PROTEIN PREPARATIONS

#279
20180200380
2018-07-19

Glycopolysialylation of non-blood coagulation proteins

#280
20180187232
2018-07-05

EFFICIENT PRODUCTION OF PEPTIDES

#281
20180186857
2018-07-05

Factor VIII protein compositions and methods of treating of hemophilia A

#282
20180185455
2018-07-05

Preparation comprising factor VIII and Von Willebrand factor peptides

#283
20180179262
2018-06-28

Compounds Suitable for Treatment of Haemophilia

#284
20180161403
2018-06-14

ADENO-ASSOCIATED VIRUS FACTOR VIII VECTORS

#285
20180153968
2018-06-07

Methods for preparing modified von Willebrand factor

#286
20180148495
2018-05-31

Variant factor VIII polypeptides and methods of their production and use

#287
20180127460
2018-05-10

Chromatographic methods for purification of proteins from plasma

#288
20180127459
2018-05-10

Method for chromatography

#289
20180120332
2018-05-03

Bi-functional arginine-glycine-aspartic acid (RGD) peptides and methods to promote angiogenesis

#290
20180092966
2018-04-05

COVALENT COMPLEX OF VON WILLEBRAND FACTOR AND FACTOR VIII, COMPOSITIONS, AND USES RELATING THERETO

#291
20180087081
2018-03-29

PROTEIN EXPRESSION ENHANCING POLYPEPTIDES

#292
20180086822
2018-03-29

METHOD FOR REDUCING THE IMMUNE RESPONSE TO A BIOLOGICALLY ACTIVE PROTEIN

#293
20180071406
2018-03-15

Optimized liver-specific expression systems for FVIII and FIX

#294
20180071405
2018-03-15

RNA guided endonuclease targeting blood coagulation factor VIII intron 1 inversion gene and composition for treating hemophilia comprising same

#295
20180055951
2018-03-01

Talen targeting blood coagulation factor VIII intron 1 inversion gene and composition for treating hemophilia comprising same

#296
20180051067
2018-02-22

Modified von Willebrand factor having improved half-life

#297
20180044405
2018-02-15

Method of producing recombinant high molecular weight vWF in cell culture

#298
20180043012
2018-02-15

COMPOUNDS FOR IMPROVING THE HALF-LIFE OF VON WILLEBRAND FACTOR

#299
20180021457
2018-01-25

Endonuclease targeting blood coagulation factor VIII gene and composition for treating hemophilia comprising same

#300
20180010090
2018-01-11

FORMULATIONS AND METHODS FOR INCREASED RECOMBINANT PROTEIN PRODUCTION