ClassID:

97292

C07K2317/66 - CPC Classification

Classification description:

Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1

Recent Application in this class:
#1
20260125470
2026-05-07

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#2
20260124298
2026-05-07

CLEC9A BINDING AGENTS

#3
20260116973
2026-04-30

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#4
20260078160
2026-03-19

LAG-3 TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND LAG-3 ANTIGEN BINDING DOMAINS

#5
20260069686
2026-03-12

CD8 BINDING AGENTS

#6
20260062477
2026-03-05

Engineered Heterodimeric Proteins

#7
20260049160
2026-02-19

TETRAVALENT MULTISPECIFIC ANTIBODIES

#8
20260022172
2026-01-22

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#9
20250382327
2025-12-18

POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS

#10
20250361319
2025-11-27

MULTISPECIFIC POLYPEPTIDE CONSTRUCTS HAVING CONSTRAINED CD3 BINDING AND RELATED METHODS AND USES

#11
20250333544
2025-10-30

TETRAVALENT BISPECIFIC AND TETRASPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF

#12
20250289877
2025-09-18

Antibodies to Amyloid Beta

#13
20250223329
2025-07-10

BIFUNCTIONAL FUSION PROTEIN COMPOSED OF IL-15 AND ANTIBODY AGAINST T CELL CO-STIMULATORY MOLECULE

#14
20250129160
2025-04-24

T CELL ENGAGER MOLECULES AND USES THEREOF

#15
20250066448
2025-02-27

HER2-TARGETING ANTIGEN BINDING MOLECULES COMPRISING 4-1BBL

#16
20250043028
2025-02-06

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#17
20250011401
2025-01-09

OPTIMIZED NUCLEIC ACID ANTIBODY CONSTRUCTS

#18
20240425616
2024-12-26

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#19
20240392020
2024-11-28

ANTIGEN-BINDING MOLECULE

#20
20240391952
2024-11-28

POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS

#21
20240317879
2024-09-26

BISPECIFIC ANTI-HUMAN CD20/HUMAN TRANSFERRIN RECEPTOR ANTIBODIES AND METHODS OF USE

#22
20240141044
2024-05-02

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#23
20240101704
2024-03-28

MULTISPECIFIC POLYPEPTIDE CONSTRUCTS HAVING CONSTRAINED CD3 BINDING AND METHODS OF USING THE SAME

#24
20240083939
2024-03-14

POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS

#25
20240059779
2024-02-22

MULTIVALENT BINDING MOLECULES

#26
20230340160
2023-10-26

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#27
20230322957
2023-10-12

MONOCLONAL ANTIBODIES AGAINST BCMA

#28
20230295336
2023-09-21

MULTISPECIFIC POLYPEPTIDE CONSTRUCTS HAVING CONSTRAINED CD3 BINDING AND RELATED METHODS AND USES

#29
20230295291
2023-09-21

ENGINEERED HETERODIMERIC PROTEINS

#30
20230287118
2023-09-14

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#31
20230279071
2023-09-07

LAG-3 TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND LAG-3 ANTIGEN BINDING DOMAINS

#32
20230227498
2023-07-20

POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS

#33
20230220114
2023-07-13

PURIFICATION OF MULTISPECIFIC ANTIBODIES

#34
20230114491
2023-04-13

Recombinant fusion proteins targeting CD47 and CD24, preparation and use thereof

#35
20230112916
2023-04-13

Neutralizing anti-influenza binding molecules and uses thereof

#36
20230068801
2023-03-02

MULTISPECIFIC ANTIBODIES

#37
20220403027
2022-12-22

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#38
20220389054
2022-12-08

POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS

#39
20220387586
2022-12-08

BISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO PD1 AND LAG3

#40
20220380482
2022-12-01

IgE Antibody with FcRn binding

#41
20220380440
2022-12-01

TRUNCATED MULTIVALENT MULTIMERS

#42
20220363771
2022-11-17

MULTISPECIFIC ANTIBODIES

#43
20220356253
2022-11-10

CLEC9A BINDING AGENTS

#44
20220306761
2022-09-29

Bispecific anti-human CD20/human transferrin receptor antibodies and methods of use

#45
20220259318
2022-08-18

ANTIBODIES BINDING TO GPRC5D

#46
20220259314
2022-08-18

BISPECIFIC ANTIBODIES SPECIFIC FOR PD1 AND TIM3

#47
20220227888
2022-07-21

BISPECIFIC BINDING CONSTRUCTS WITH SELECTIVELY CLEAVABLE LINKERS

#48
20220227867
2022-07-21

ICOS TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND ICOS ANTIGEN BINDING DOMAINS

#49
20220220224
2022-07-14

T cell activating bispecific antigen binding molecules

#50
20220213226
2022-07-07

ANTI-TL1A/ANTI-TNF-ALPHA BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF

#51
20220213225
2022-07-07

MULTISPECIFIC TREG BINDING MOLECULES

#52
20220177586
2022-06-09

CD8 BINDING AGENTS

#53
20220135618
2022-05-05

POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS

#54
20220073646
2022-03-10

BISPECIFIC ANTIBODIES WITH TETRAVALENCY FOR A COSTIMULATORY TNF RECEPTOR

#55
20220056089
2022-02-24

ENGINEERED OPSONIN FOR PATHOGEN DETECTION AND TREATMENT

#56
20220049020
2022-02-17

TETRAVALENT MULTISPECIFIC ANTIBODIES

#57
20210395396
2021-12-23

HER2-BINDING TETRAMERIC POLYPEPTIDES

#58
20210388341
2021-12-16

MULTISPECIFIC ANTIBODY SCREENING METHOD USING RECOMBINASE MEDIATED CASSETTE EXCHANGE

#59
20210309730
2021-10-07

MULTISPECIFIC ANTIBODIES

#60
20210292360
2021-09-23

POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS

#61
20210253741
2021-08-19

BISPECIFIC ANTIBODIES

#62
20210253736
2021-08-19

Heterodimeric antibodies that bind fibroblast activation protein

#63
20210189011
2021-06-24

Dual Variable Region Antibody-Like Binding Proteins Having Cross-Over Binding Region Orientation

#64
20210188947
2021-06-24

Optimized nucleic acid antibody constructs encoding anti-respiratory syncytial virus (RSV) antibodies

#65
20210139586
2021-05-13

BISPECIFIC SIGNALING AGENTS AND USES THEREOF

#66
20210115123
2021-04-22

TRISPECIFIC INHIBITORS FOR CANCER TREATMENT

#67
20210087259
2021-03-25

Bispecific HIV-1-neutralizing antibodies

#68
20210079120
2021-03-18

Method for increasing the percentage of monomeric antibody Fab-dsFv multimeric species

#69
20210079069
2021-03-18

Neutralizing anti-influenza binding molecules and uses thereof

#70
20210070882
2021-03-11

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#71
20210040147
2021-02-11

POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS

#72
20210024610
2021-01-28

HER2-targeting antigen binding molecules comprising 4-1BBL

#73
20210002376
2021-01-07

Multivalent binding molecules

#74
20210002348
2021-01-07

Antagonists targeting the TGF-β pathway

#75
20200384118
2020-12-10

IMMUNOTOXIN CONJUGATES FOR USE IN THERAPY

#76
20200369758
2020-11-26

Bispecific antigen binding proteins

#77
20200369719
2020-11-26

Depletion of light chain mispaired antibody variants by hydrophobic interaction chromatography

#78
20200317761
2020-10-08

Multispecific binding molecules having specificity to dystroglycan and laminin-2

#79
20200308258
2020-10-01

Anti-HERV-K envelope protein antibodies and methods for detecting HERV-K envelope protein in patients with sporadic amyotrophic lateral sclerosis

#80
20200299345
2020-09-24

Engineered opsonin for pathogen detection and treatment

#81
20200291131
2020-09-17

Bispecific HER2 antibodies and methods of use

#82
20200291083
2020-09-17

Engineered opsonin for pathogen detection and treatment

#83
20200283545
2020-09-10

MONOCLONAL ANTIBODIES AGAINST BCMA

#84
20200231673
2020-07-23

Bispecific T cell activating antigen binding molecules

#85
20200231665
2020-07-23

Antagonists targeting the TGF-β pathway

#86
20200216559
2020-07-09

Heterodimeric antibodies that bind CD3 and PSMA

#87
20200216554
2020-07-09

BISPECIFIC ANTI-HUMAN CD20/HUMAN TRANSFERRIN RECEPTOR ANTIBODIES AND METHODS OF USE

#88
20200207805
2020-07-02

POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS

#89
20200181247
2020-06-11

Humanized antibodies binding to amyloid-beta (A-beta)

#90
20200165356
2020-05-28

Heterodimeric antibodies that bind fibroblast activation protein

#91
20200115464
2020-04-16

Methods and antibody compositions for tumor treatment

#92
20200109187
2020-04-09

Neutralizing anti-influenza binding molecules and uses thereof

#93
20200095300
2020-03-26

Engineered opsonin for pathogen detection and treatment

#94
20190382475
2019-12-19

Engineered heterodimeric proteins

#95
20190375838
2019-12-12

PROTEINS BINDING BCMA, NKG2D AND CD16

#96
20190367604
2019-12-05

Bispecific signaling agents and uses thereof

#97
20190359684
2019-11-28

TIM-3 targeted heterodimeric fusion proteins containing IL-15/IL-15RA Fc-fusion proteins and TIM-3 antigen binding domains

#98
20190352427
2019-11-21

Monoclonal antibodies against BCMA

#99
20190352406
2019-11-21

Clec9A binding agents

#100
20190352362
2019-11-21

LAG-3 TARGETED HETERODIMERIC FUSION PROTEINS CONTAINING IL-15/IL-15RA Fc-FUSION PROTEINS AND LAG-3 ANTIGEN BINDING DOMAINS

#101
20190352334
2019-11-21

POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS

#102
20190345245
2019-11-14

Methods of Treating Crohn's Disease with Anti-IL23 Specific Antibody

#103
20190345232
2019-11-14

Methods for alleviating symptoms of sporadic amyotrophic lateral sclerosis by neutralizing a HERV-K envelope protein using an anti-HERV-K envelope protein antibody

#104
20190330366
2019-10-31

MULTISPECIFIC POLYPEPTIDE CONSTRUCTS HAVING CONSTRAINED CD3 BINDING AND RELATED METHODS AND USES

#105
20190322748
2019-10-24

Bispecific antibodies specific for PD1 and TIM3

#106
20190284299
2019-09-19

Heterodimeric immunoglobulin constructs and preparation methods thereof

#107
20190211113
2019-07-11

BISPECIFIC ANTIBODIES WITH TETRAVALENCY FOR A COSTIMULATORY TNF RECEPTOR

#108
20190177413
2019-06-13

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#109
20190119407
2019-04-25

Anti-TL1A/anti-TNF-alpha bispecific antigen binding proteins and uses thereof

#110
20190071500
2019-03-07

CD8 binding agents

#111
20190062453
2019-02-28

Antibodies specific for DR5 and methods of use

#112
20190062368
2019-02-28

POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS

#113
20190048098
2019-02-14

Bispecific antibody platform

#114
20190031784
2019-01-31

T CELL ACTIVATING BISPECIFIC ANTIGEN BINDING MOLECULES

#115
20190010242
2019-01-10

Multispecific polypeptide constructs having constrained CD3 binding and methods of using the same

#116
20190002565
2019-01-03

Bispecific T cell activating antigen binding molecules

#117
20190002564
2019-01-03

Bispecific T cell activating antigen binding molecules

#118
20190002544
2019-01-03

Blood-brain barrier permeable peptide compositions comprising a VAB domain of an anti-amyloid-beta camelid single-domain heavy-chain only antibody

#119
20180326054
2018-11-15

Bispecific antibodies specifically binding to PD1 and LAG3

#120
20180312589
2018-11-01

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#121
20180312573
2018-11-01

Nucleic acid encoding dual Fc antigen binding proteins

#122
20180282410
2018-10-04

ANTI-CD3XROB04 BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#123
20180273643
2018-09-27

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#124
20180237542
2018-08-23

TETRAVALENT BISPECIFIC AND TETRASPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF

#125
20180237527
2018-08-23

Antibody fragments, compositions and uses thereof

#126
20180237511
2018-08-23

Multispecific binding molecules having specificity to dystroglycan and laminin-2

#127
20180237505
2018-08-23

Bispecific HIV-1-neutralizing antibodies

#128
20180222993
2018-08-09

Bispecific anti-human CD20/human transferrin receptor antibodies and methods of use

#129
20180222991
2018-08-09

Method for the selection of antibodies against BCMA

#130
20180222981
2018-08-09

Bispecific T cell activating antigen binding molecules

#131
20180222980
2018-08-09

Bispecific T cell activating antigen binding molecules

#132
20180162902
2018-06-14

POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS

#133
20180155450
2018-06-07

Dual Variable Region Antibody-Like Binding Proteins Having Cross-Over Binding Region Orientation

#134
20180155413
2018-06-07

Neutralizing anti-influenza binding molecules and uses thereof

#135
20180142039
2018-05-24

Method for increasing the percentage of monomeric antibody Fab-dsFv multimeric species

#136
20180118849
2018-05-03

Bispecific T cell activating antigen binding molecules

#137
20180100016
2018-04-12

USE OF CAR-MODIFIED HUMAN NATURAL KILLER CELLS TO TREAT CANCER

#138
20180094035
2018-04-05

Engineered opsonin for pathogen detection and treatment

#139
20180086849
2018-03-29

Bispecific T cell activating antigen binding molecules

#140
20180079805
2018-03-22

Bispecific antigen binding proteins

#141
20180057567
2018-03-01

Multispecific antibodies facilitating selective light chain pairing

#142
20180037633
2018-02-08

Monovalent antigen binding proteins

#143
20180016354
2018-01-18

Domain-exchanged antibody

#144
20170334992
2017-11-23

BISPECIFIC MOLECULE BINDING TLR9 AND CD32 AND COMPRISING A T CELL EPITOPE FOR TREATMENT OF ALLERGIES

#145
20170320943
2017-11-09

Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies

#146
20170320942
2017-11-09

BISPECIFIC MOLECULE BINDING TLR9 AND CD32 AND COMPRISING A T CELL EPITOPE FOR TREATMENT OF ALLERGIES

#147
20170306044
2017-10-26

BISPECIFIC ANTIBODIES AGAINST CD3EPSILON AND ROR1 FOR USE IN THE TREATMENT OF OVARIAN CANCER

#148
20170306036
2017-10-26

Bispecific antibodies against CD3ϵ and BCMA

#149
20170275353
2017-09-28

Trispecific inhibitors for cancer treatment

#150
20170275332
2017-09-28

POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS

#151
20170240626
2017-08-24

BISPECIFIC, BIVALENT ANTI-VEGF/ANTI-ANG-2 ANTIBODIES

#152
20170190783
2017-07-06

Bispecific T cell activating antigen binding molecules

#153
20170174786
2017-06-22

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#154
20170145116
2017-05-25

TETRAVALENT MULTISPECIFIC ANTIBODIES

#155
20170129962
2017-05-11

MULTISPECIFIC ANTIBODIES

#156
20170114146
2017-04-27

Bispecific T cell activating antigen binding molecules

#157
20170114135
2017-04-27

Bispecific antibodies specific for PD1 and TIM3

#158
20170096495
2017-04-06

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#159
20170096485
2017-04-06

BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES

#160
20170014526
2017-01-19

ANTI-NOTCH3 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES

#161
20160376304
2016-12-29

Separation of bispecific antibodies and bispecific antibody production side products using hydroxyapatite chromatography

#162
20160289341
2016-10-06

Fabs-in-tandem immunoglobulin and uses thereof

#163
20160200785
2016-07-14

ENGINEERED OPSONIN FOR PATHOGEN DETECTION AND TREATMENT

#164
20160159917
2016-06-09

Trimeric antigen binding molecules

#165
20160130347
2016-05-12

Fc-free antibodies comprising two fab-fragments and methods of use

#166
20160108105
2016-04-21

HUMAN IGG4 FC POLYPEPTIDE VARIANT

#167
20160075785
2016-03-17

Bispecific T cell activating antigen binding molecules

#168
20160017044
2016-01-21

Antibody fragments, compositions and uses thereof

#169
20160009824
2016-01-14

TETRAVALENT BISPECIFIC ANTIBODIES

#170
20150376287
2015-12-31

Bispecific antibodies against CD3 and BCMA

#171
20150368351
2015-12-24

Method for the selection of antibodies against BCMA

#172
20150274845
2015-10-01

Bispecific antibodies specific for T-cell activating antigens and a tumor antigen and methods of use

#173
20150266960
2015-09-24

Antibodies with engineered IgG Fc domains

#174
20150191535
2015-07-09

BISPECIFIC, BIVALENT ANTI-VEGF/ANTI-ANG2 ANTIBODIES

#175
20150030598
2015-01-29

TRI- OR TETRASPECIFIC ANTIBODIES

#176
20140370019
2014-12-18

Bispecific antibodies specific for FAP and DR5, antibodies specific for DR5

#177
20140341906
2014-11-20

Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto

#178
20140302038
2014-10-09

Multispecific and multivalent binding proteins and uses thereof

#179
20140242079
2014-08-28

Bispecific T cell activating antigen binding molecules

#180
20140112927
2014-04-24

Bispecific monoclonal antibody therapeutics against West Nile virus with improved CNS penetration

#181
20130295084
2013-11-07

Binding proteins having tethered light chains

#182
20130230525
2013-09-05

Protein complexes for antigen binding and methods of use

#183
20130060011
2013-03-07

FC-FREE ANTIBODIES COMPRISING TWO FAB FRAGMENTS AND METHODS OF USE

#184
20130058937
2013-03-07

Bispecific antigen binding molecules

#185
20130058936
2013-03-07

BISPECIFIC ANTIBODIES SPECIFIC FOR T-CELL ACTIVATING ANTIGENS AND A TUMOR ANTIGEN AND METHODS OF USE

#186
20130035283
2013-02-07

Engineered opsonin for pathogen detection and treatment

#187
20130018174
2013-01-17

POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS

#188
20120251541
2012-10-04

Dual Variable Region Antibody-Like Binding Proteins Having Cross-Over Binding Region Orientation

#189
20120237507
2012-09-20

Monovalent Antigen Binding Proteins

#190
20120237506
2012-09-20

Dual FC antigen binding proteins

#191
20110236388
2011-09-29

Bispecific, bivalent anti-VEGF/anti-ANG-2 antibodies

#192
20100322935
2010-12-23

Tri- or tetraspecific antibodies

#193
20100322934
2010-12-23

Bispecific, tetravalent antigen binding proteins

#194
20100316645
2010-12-16

Bispecific antigen binding proteins

#195
20100143342
2010-06-10

BISPECIFIC MOLECULE BINDING TLR9 AND CD32 AND COMPRISING A T CELL EPITOPE FOR TREATMENT OF ALLERGIES