109024 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; Processes for the isolation, preparation or purification of DNA or RNA; Mutagenizing nucleic acids mutagenesis using high mutation rate "mutator" host strains by inserting genetic material, e.g. encoding an error prone polymerase, disrupting a gene for mismatch repair
RNA-Guided Endonuclease Fusion Polypeptides and Methods of Use Thereof
#2METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
#3KINASE MUTANTS AND USES THEREOF
#4SYSTEMS AND METHODS FOR TARGETED CONTINUOUS GENOME MUTAGENESIS
#5ARTIFICIAL DNA REPLISOME AND METHODS OF USE THEREOF
#6MICROORGANISMS AND USES THEREOF
#7RNA BASE EDITING COMPOSITIONS, SYSTEMS, METHODS AND USES THEREOF
#8SYSTEM FOR INDUCING MUTATION BASED ON OPTIMIZED ACTIVATION-INDUCED CYTIDINE DEAMINASE
#9METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES
#10ADENOSINE NUCLEOBASE EDITORS AND USES THEREOF
#11Gene Targeting
#12NOVEL RNA BASE EDITING COMPOSITIONS, SYSTEMS, METHODS AND USES THEREOF
#13ERROR PRONE DNA POLYMERASE FOR ORGANELLE MUTATION
#14Microinjection system and method
#15Split Cas9 Proteins
#16T CELL RECEPTOR, AND PREPARATION METHOD AND USE THEREOF
#17RNA-Guided Human Genome Engineering
#18RNA-Guided Human Genome Engineering
#19METHODS OF PERIPLASMIC PHAGE-ASSISTED CONTINUOUS EVOLUTION
#20Nuclease-Based RNA Depletion
#21ELECTROPORATION, DEVELOPMENTALLY-ACTIVATED CELLS, PLURIPOTENT-LIKE CELLS, CELL REPROGRAMMING AND REGENERATIVE MEDICINE
#22Method to Screen For a Mutant Within a Population of Organisms By Applying a Pooling and Splitting Approach
#23METHODS AND SYSTEMS FOR GENERATING NUCLEIC ACID DIVERSITY
#24KINASE MUTANTS AND USES THEREOF
#25COMPACT PROMOTERS FOR GENE EDITING
#26MICROORGANISMS AND USES THEREOF
#27ENGINEERED BI-STABLE TOGGLE SWITCH AND USES THEREOF
#28MICROORGANISMS AND USES THEREOF
#29Method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides
#30METHOD FOR PRODUCING RNA MOLECULE COMPOSITIONS
#31CRISPR ENABLED MULTIPLEXED GENOME ENGINEERING
#32Adenosine nucleobase editors and uses thereof
#33METHODS AND COMPOSITIONS FOR THE TARGETED MODIFICATION OF A GENOME
#34RNA-GUIDED ENDONUCLEASE FUSION POLYPEPTIDES AND METHODS OF USE THEREOF
#35RNA-GUIDED ENDONUCLEASE FUSION POLYPEPTIDES AND METHODS OF USE THEREOF
#36Platform for developing stable mammalian cell lines
#37ELECTROPORATION, DEVELOPMENTALLY-ACTIVATED CELLS, PLURIPOTENT-LIKE CELLS, CELL REPROGRAMMING AND REGENERATIVE MEDICINE
#38RNA-guided human genome engineering
#39A HIGHLY ERROR-PRONE ORTHOGONAL DNA REPLICATION SYSTEM FOR TARGETED CONTINUOUS EVOLUTION IN VIVO
#40SINGLE-STRANDED OLIGONUCLEOTIDE
#41RNA STABILIZATION
#42TARGETING TRANSFER RNA FOR THE SUPPRESSION OF NONSENSE MUTATIONS IN MESSENGER RNA
#43METHODS FOR THE TREATMENT OF EPILEPSY
#44CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING SICKLE CELL DISEASE
#45CRISPR/Cas-related methods and compositions for treating Leber's congenital amaurosis 10 (LCA10)
#46Nuclease-based RNA depletion
#47CRISPR enabled multiplexed genome engineering
#48Sequence-specific antimicrobials by blocking DNA repair
#49REDUCING BLOOD GLUCOSE, INSULIN RESISTANCE, OR HYPERLIPIDEMIA THROUGH RLIP76 PARTIAL DEPLETION
#50A METHOD FOR DEVELOPMENTALLY ACTIVATING A CELL
#51CANCER TREATMENT THROUGH RLIP76 PARTIAL DEPLETION
#52NOVEL CRISPR DNA TARGETING ENZYMES AND SYSTEMS
#53METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
#54RNA-guided human genome engineering
#55A PSEUDO-RANDOM DNA EDITOR FOR EFFICIENT AND CONTINUOUS NUCLEOTIDE DIVERSIFICATION IN HUMAN CELLS
#56RNA STABILIZATION
#57CRISPR enabled multiplexed genome engineering
#58METHODS OF PURIFYING RIBONUCLEIC ACID SPECIES
#59CRISPR GUIDE-RNA EXPRESSION STRATEGIES FOR MULTIPLEX GENOME ENGINEERING
#60RNA-guided endonuclease fusion polypeptides and methods of use thereof
#61NEW BACTERIA
#62Adenosine nucleobase editors and uses thereof
#63GM-CSF and IL-4 Conjugates, Compositions, and Methods Related Thereto
#64CRISPR enabled multiplexed genome engineering
#65ENGINEERED BI-STABLE TOGGLE SWITCH AND USES THEREOF
#66RNA-Guided Human Genome Engineering
#67BACTERIAL VECTORS FOR GENETIC MANIPULATION OF BACTERIA
#68METHOD FOR MODIFYING GENOME SEQUENCE TO INTRODUCE SPECIFIC MUTATION TO TARGETED DNA SEQUENCE BY BASE-REMOVAL REACTION, AND MOLECULAR COMPLEX USED THEREIN
#69METHODS FOR ASSESSING SPECIFICITY OF CELL ENGINEERING TOOLS
#70DNA damage response signature guided rational design of CRISPR-based systems and therapies
#71VECTORS & METHODS
#72Compositions and Methods for Multiplexed Genome Editing and Screening
#73IMPROVED BCL11A MICRORNAS FOR TREATING HEMOGLOBINOPATHIES
#74Yeast with improved alcohol production under high dissolved solids conditions
#75CRISPR enabled multiplexed genome engineering
#76SELF-DIVERSIFYING SYSTEMS AND METHODS OF USE THEREOF
#77Methods and products for expressing proteins in cells
#78RNA-Guided Human Genome Engineering
#79Adenine DNA base editor variants with reduced off-target RNA editing
#80CRISPR-BASED THERAPEUTICS FOR TARGETING HTRA1 AND METHODS OF USE
#81Methods and compositions for the targeted modification of a genome
#82GENOMIC SEQUENCE MODIFICATION METHOD FOR SPECIFICALLY CONVERTING NUCLEIC ACID BASES OF TARGETED DNA SEQUENCE, AND MOLECULAR COMPLEX FOR USE IN SAME
#83RNA-guided endonuclease fusion polypeptides and methods of use thereof
#84Single-stranded oligonucleotide
#85Genomic sequence modification method for specifically converting nucleic acid bases of targeted DNA sequence, and molecular complex for use in same
#86Nuclease-based RNA depletion
#87Repairing compound heterozygous recessive mutations by allele exchange
#88CRISPR enabled multiplexed genome engineering
#89CRISPR enabled multiplexed genome engineering
#90Platform for developing stable mammalian cell lines
#91Sequence-specific antimicrobials by blocking DNA repair
#92Kinase mutants and uses thereof
#93COMPOSITIONS AND METHODS FOR ENHANCING HOMOLOGOUS RECOMBINATION
#94Methods and products for expressing proteins in cells
#95RNA-guided human genome engineering
#96Electroporation, developmentally-activated cells, pluripotent-like cells, cell reprogramming and regenerative medicine
#97Methods and products for expressing proteins in cells
#98Methods and products for expressing proteins in cells
#99Methods and products for expressing proteins in cells
#100Method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides
#101Methods and products for expressing proteins in cells
#102Methods and products for expressing proteins in cells
#103Methods and products for expressing proteins in cells
#104Methods and products for expressing proteins in cells
#105Methods and products for expressing proteins in cells
#106Methods and compositions for treating Leber congenital amaurosis
#107Mutagenizing intracellular nucleic acids
#108CRISPR/CAS-related methods and compositions for treating Leber's Congenital Amaurosis 10 (LCA10)
#109METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES
#110CRISPR enabled multiplexed genome engineering
#111CRISPR enabled multiplexed genome engineering
#112Allele-specific capture of nucleic acids
#113Methods and products for expressing proteins in cells
#114Methods for the production of libraries for directed evolution
#115AAV Split Cas9 Genome Editing and Transcriptional Regulation
#116ASSAYS TO IDENTIFY GENETIC ELEMENTS AFFECTING PHENOTYPE
#117Genetically Modified Cell Lines Including a TP53 Modification and Methods of Use
#118METHODS FOR INCREASING THE FREQUENCY OF GENE TARGETING BY CHROMATIN MODIFICATION
#119CRISPR enabled multiplexed genome engineering
#120PROTEIN ENGINEERING METHODS
#121NEGATIVE SELECTION AND STRINGENCY MODULATION IN CONTINUOUS EVOLUTION SYSTEMS
#122RNA-guided human genome engineering
#123RNA-guided human genome engineering
#124Methods, systems and devices for selection and generation of genome edited clones
#125Method to screen for a mutant within a population of organisms by applying a pooling and splitting approach
#126CRISPR enabled multiplexed genome engineering
#127METHOD FOR THE FERMENTATIVE PRODUCTION OF L-LYSINE
#128Mutation of the ZMCIPK15 gene to increase root angle and to enhance abiotic stress tolerance in maize
#129Methods and compositions for the targeted modification of a mouse ES cell genome
#130Adenosine nucleobase editors and uses thereof
#131Method for producing RNA molecule compositions
#132GENOME EDITING IN RATS USING ZINC-FINGER NUCLEASES
#133Cancer treatment through RLIP76 partial depletion
#134Molecular cell diary system
#135GM-CSF and IL-4 conjugates, compositions, and methods related thereto
#136CRISPR enabled multiplexed genome engineering
#137YIELD PROMOTER TO INCREASE SUCROSE AND SUCROSE DERIVATIVES IN PLANTS
#138CRISPR enabled multiplexed genome engineering
#139CRISPR enabled multiplexed genome engineering
#140System for continuous mutagenesis in vivo to facilitate directed evolution
#141Method for introducing site-directed RNA mutation, target editing guide RNA used in the method and target RNA-target editing guide RNA complex
#142Allele-specific capture of nucleic acids
#143IMPROVING SEQUENCE-SPECIFIC ANTIMICROBIALS BY BLOCKING DNA REPAIR
#144CRISPR/CAS-related methods and compositions for treating Leber's Congenital Amaurosis 10 (LCA10)
#145Methods to accelerate antibody diversification
#146Assays to identify genetic elements affecting phenotype
#147Split Cas9 Proteins
#148Methods, systems and devices for selection and generation of genome edited clones
#149Adenosine nucleobase editors and uses thereof
#150Functional screening with optimized functional CRISPR-Cas systems
#151Use and production of CHD8+/− transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
#152Compositions and methods for enhancing homologous recombination
#153Methods for Modulating Genome Editing
#154Methods and products for expressing proteins in cells
#155CRISPR enabled multiplexed genome engineering
#156Method for modifying genome sequence to introduce specific mutation to targeted DNA sequence by base-removal reaction, and molecular complex used therein
#157Method for RGEN RNP delivery using 5′-phosphate removed RNA
#158CRISPR/CAS-related methods and compositions for treating sickle cell disease
#159Cloning method
#160DNA SEQUENCE AND A MUTATOR INSERTION SEQUENCE FOR INCREASING MUTATION RATE
#161Methods and compositions for treating leber congenital amaurosis
#162CRISPR enabled multiplexed genome engineering
#163Methods and products for expressing proteins in cells
#164Methods for the production of libraries for directed evolution
#165GENOMICALLY-ENCODED MEMORY IN LIVE CELLS
#166Methods of introducing nucleic acids into cellular DNA
#167TARGETED ALTERATION OF DNA WITH OLIGONUCLEOTIDES
#168Genomic sequence modification method for specifically converting nucleic acid bases of targeted DNA sequence, and molecular complex for use in same
#169Methods and compositions for the targeted modification of a mouse embryonic stem cell genome
#170METHODS FOR IN VIVO GENOME EDITING
#171Methods and products for expressing proteins in cells
#172Negative selection and stringency modulation in continuous evolution systems
#173RNA-guided human genome engineering
#174Methods for the production of libraries for directed evolution
#175Coexpression of CAS9 and TREX2 for targeted mutagenesis
#176Methods and products for expressing proteins in cells
#177Inducible mutagenesis of target genes
#178Methods for cloning and manipulating genomes
#179RNA-guided human genome engineering
#180GENOME EDITING IN RATS USING ZINC-FINGER NUCLEASES
#181METHODS AND COMPOSITIONS FOR THE TARGETED MODIFICATION OF A GENOME
#182RNA-guided human genome engineering
#183Methods and compositions for treating hemophilia B
#184RNA-guided human genome engineering
#185Recombinant yeast having enhanced xylose fermentation capabilities and methods of use
#186METHOD FOR GENERATING SITE-SPECIFIC MUTATIONS IN FILAMENTOUS FUNGI
#187Oligonucleotide complex compositions and methods of use as gene alteration tools
#188Apparatus for continuous directed evolution of proteins and nucleic acids
#189Methods and products for expressing proteins in cells
#190Methods and products for expressing proteins in cells
#191CRISPR/CAS-related methods and compositions for treating leber's congenital amaurosis 10 (LCA10)
#192RNA-Guided Human Genome Engineering
#193Methods and compositions for the targeted modification of a mouse genome
#194Cloning method
#195RNA-guided human genome engineering
#196Cell-based methods for coupling protein interactions and binding molecule selection
#197Methods of introducing nucleic acids into cellular DNA
#198Targeted alteration of DNA with oligonucleotides
#199Methods and compositions for targeted mutagenesis in bacteria
#200TARGETING OF MODIFYING ENZYMES FOR PROTEIN EVOLUTION
#201Oligonucleotide complex compositions and methods of use as gene alteration tools
#202Methods and compositions for treating hemophilia B
#203CIS-ACTING DIVERSIFICATION ACTIVATOR AND METHOD FOR SELECTIVE DIVERSIFICATION OF NUCLEIC ACIDS
#204Continuous directed evolution of proteins and nucleic acids
#205Method for generating hypermutable plants
#206Methods for cloning and manipulating genomes
#207Methods of generating high-production of antibodies from hybridomas created by in vitro immunization
#208Method of deleting an IgM gene in an isolated rat cell
#209Tailored multi-site combinatorial assembly
#210B cells modified to reversibly induce accelerated mutagenesis of target genes
#211Genetically Altered Anti-body Producing Cell Lines With Improved Antibody Characteristics
#212Methods For Generating Enhanced Antibody-Producing Cell Lines With Improved Growth Characteristics
#213Method for generating hypermutable organisms
#214Antibodies and methods for generating genetically altered antibodies with enhanced effector function
#215Techniques for recording signals
#216Methods for generating hypermutable microbes
#217Method for generating hypermutable organisms
#218Oligonucleotide complex compositions and methods of use as gene alteration tools
#219Method for generating diversity
#220Whole Genome Evolution Technology Applied To Improve Protein And Antibody Yields By Cells
#221Antibodies and methods for generating genetically altered antibodies with high affinity
#222Generation Of Recombinant Genes In Prokaryotic Cells By Using Two Extrachromosomal Elements
#223Methods for genetic diversification in gene conversion active cells
#224Forward mutation assay based on 5-fluorouracil resistance
#225Methods for generating hypermutable microbes
#226Site specific system for generating diversity protein sequences
#227Method for generating hypermutable plants
#228Method for generating hypermutable organisms
#229Antibodies and methods for generating genetically altered antibodies with enhanced effector function
#230Genetically altered antibody-producing cell lines with improved antibody characteristics
#231Techniques for recording signals
#232Method for generating diversity
#233Laboratory directed evolution via HG-Selection
#234Site-directed RNA editing