109047 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof General methods applicable to biologically active non-coding nucleic acids
Polymeric micelle particle comprising anionic drugs and method of preparing the same
#2702Compositions for targeted delivery of siRNA
#2703Single-stranded RNAi agents containing an internal, non-nucleic acid spacer
#2704Universal protein tag for double stranded nucleic acid delivery
#2705Nano-constructs for polynucleotide delivery
#2706Use of novel monosaccharide-like glycylated sugar alcohol compositions for designing and developing anti-diabetic drugs
#2707CRISPR hybrid DNA/RNA polynucleotides and methods of use
#2708Nucleic acids and methods for the treatment of Pompe disease
#2709Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents
#2710Ph-sensitive peptides and their nanoparticles for drug delivery
#2711Liposome for topical administration and application thereof
#2712RNA/DNA nanoparticle for siRNA target-specific delivery and vehicle including the same
#2713CRISPR enzymes and systems
#2714Hydrogels for delivery of therapeutic compounds
#2715Tyrosine-based lipids for delivery of therapeutics
#2716Acellular pro-inflammatory compositions, process for making same and methods of using same
#2717Nanocomplexes for co-delivering a drug and siRNA and uses thereof
#2718Methods and compositions for selecting siRNA of improved functionality
#2719Methods and compositions for selecting siRNA of improved functionality
#2720Lipids and compositions for the delivery of therapeutics
#2721Methods and compositions for selecting siRNA of improved functionality
#2722Targeting non-coding RNA for RNA interference
#2723REDUCING NONSENSE-MEDIATED MRNA DECAY
#2724Methods and compositions for selecting siRNA of improved functionality
#2725Processes and host cells for genome, pathway, and biomolecular engineering
#2726Synthetic nanostructures including nucleic acids and/or other entities
#2727Esophageal microRNA expression profiles in eosinophilic esophagitis
#2728CRISPR-based compositions and methods of use
#2729Antisense molecules and methods for treating pathologies
#2730Means and methods for the generation of mammalian producer cells for the production of recombinant proteins
#2731Stem cells for modeling type 2 diabetes
#2732System for delivering therapeutic agents into living cells and cells nuclei
#2733Peptide sequence design and use thereof for peptide-mediated siRNA delivery
#2734Sphingolipid-polyalkylamine-oligonucleotide compounds
#2735Multiplex RNA-guided genome engineering
#2736Delivery of therapeutic agent
#2737UNA single stranded oligomers for therapeutics
#2738In-vivo monitoring of molecular targets
#2739Polynucleotides for multivalent RNA interference, compositions and methods of use thereof
#2740Compositions and methods for regulating gene expression via RNA interference
#2741Therapeutic phages and methods for delivery of nucleic acids for therapeutic uses
#2742Compositions and methods for efficacious and safe delivery of siRNA using specific chitosan-based nanocomplexes
#2743Compositions and methods for controlled delivery of inhibitory ribonucleic acids
#2744Antisense oligonucleotide compositions
#2745RIG-I ligands and methods for producing them
#2746Method of regulating gene expression
#2747Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
#2748Low density lipoprotein receptor-mediated siRNA delivery
#2749Nucleic acid particles, methods and use thereof
#2750Oligomers with improved off-target profile
#2751Albumin production and cell proliferation
#2752Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof
#2753Compositions and methods for the delivery of nucleic acids
#2754Nuclease-resistant DNA analogues
#2755Dosage compensating transgenes and cells
#2756Method to bioengineer designer platelets using gene editing and stem cell methodologies
#2757Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#2758Isolation of novel AAV's and uses thereof
#2759Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#2760Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#2761Interfering RNA molecules
#2762RNA amidates and thioamidates for RNAi
#2763Adipocyte-targeting non-viral gene delivery system
#2764Reduced size self-delivering RNAi compounds
#2765Methods for maturing cardiomyocytes and uses thereof
#2766Oligonucleotide analogues incorporating 5-aza-cytosine therein
#2767Compounds and methods for trans-membrane delivery of molecules
#2768Liposomes for modulating Wiskott-Aldrich syndrome protein
#2769Lipid encapsulating interfering RNA
#2770Hydrophobically modified antisense oligonucleotides comprising a triple alkyl chain
#2771Delivering functional nucleic acids to mammalian cells via bacterially-derived, intact minicells
#2772Hydrophobically modified antisense oligonucleotides comprising a ketal group
#2773Antisense antibacterial compounds and methods
#2774Compounds and methods for trans-membrane delivery of molecules
#2775Methods and compositions for templated assembly of nucleic acid specific heterocompounds
#2776Oligonucleotide analogues targeting human LMNA
#2777Compositions and methods for modulating apolipoprotein (a) expression
#2778Compositions and methods for modulating apolipoprotein C-III expression
#2779Phase changing formulations of nucleic acid payloads
#2780Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same
#2781Foreign DNA surveillance protein
#2782Therapeutic compositions
#2783Nanoparticle mediated delivery of siRNA
#2784Morpholino oligonucleotide manufacturing method
#2785Compositions and methods
#2786Phosphorous-linked oligomeric compounds and their use in gene modulation
#2787Compositions and methods for modulating HBV expression
#2788Recombinant adeno-associated virus delivery of exon 2-targeted U7SNRNA polynucleotide constructs
#2789Aptamer methods and compositions
#2790Hydrazinyl lipidoids and uses thereof
#2791Methods of identifying compounds for the treatment of fibrosis by using S1PR5
#2792Short interfering nucleic acid (siNA) molecules containing a 2′ internucleoside linkage
#2793Composition for delivery of genetic material
#2794Method for evaluating redox activity of nucleic acid molecule and nucleic acid molecule having redox activity
#2795T-cell-specific humanized single fragment antibody delivery vehicle
#2796Placental like alkaline phosphatase (PLAP) promoter mediated cell targeting
#2797Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
#2798Biocompatible infinite coordination polymer nanoparticle-nucleic acid conjugates for antisense gene regulation
#2799Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells
#2800Viral and viral associated miRNAs and uses thereof
#2801Biodegradable and clinically-compatible nanoparticles as drug delivery carriers
#2802HSA-MIR-146B-5P-related nucleic acids and uses thereof
#2803Signal activated RNA interference
#2804Site-specific induction of bimolecular quadruplex-duplex hybrids and methods of using the same
#2805Long interfering nucleic acid duplexes targeting multiple RNA targets
#2806Morpholinos, morpholino upregulating, and associated methods
#2807Compositions and methods for in vivo excision of HIV-1 proviral DNA
#2808siRNA-mediated gene silencing
#2809Aptamer-guided gene targeting
#2810RNA sequence-specific mediators of RNA interference
#2811Method of deriving mature hepatocytes from human embryonic stem cells
#2812Random RNAi libraries, methods of generating same, and screening methods utilizing same
#2813Vectors for delivery of agents across biological membranes
#2814Therapeutic agent for fibroid lung
#2815Therapeutic alteration of transplantable tissues through in situ or ex vivo exposure to RNA interference molecules
#2816Methods for increasing efficacy of lipid formulated siRNA
#2817Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#2818Reducing intron retention
#2819Method for expressing, secreting and transferring functional microRNAs/siRNAs and application thereof
#2820Methods and compositions for RNA-guided treatment of HIV infection
#2821Bridged bicyclic nucleosides
#2822Method for inhibiting tumor growth through RNA-interference using liposomally associated CDC20 siRNA
#2823Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent
#2824Vectors and methods for genetic immunization
#2825Multiple exon skipping compositions for DMD
#2826Multiple exon skipping compositions for DMD
#2827Multiple exon skipping compositions for DMD
#2828miRNA profiling compositions and methods of use
#2829Multiple exon skipping compositions for DMD
#2830Multiple exon skipping compositions for DMD
#2831Segmented micro RNA mimetics
#2832Oligonucleotide
#2833Treatment of metastatic tumors
#2834Composition for gene delivery comprising chitosan and liquid crystal formation material
#2835Process for formulating an anionic agent
#2836Lipid formulations for delivery of therapeutic agents to solid tumors
#2837ShRNA molecules and methods of use thereof
#2838Positively charged polysaccharides for RNA transfection
#2839Method of producing dicer
#2840Lipids, lipid complexes and use thereof
#2841Compositions and methods for inhibiting expression of a target gene
#2842Peptide-based in vivo siRNA delivery system
#2843Plants as functional microRNA and/or functional siRNA carriers, preparation methods and uses thereof
#2844Polyvalent RNA-nanoparticle compositions
#2845Methods and compositions involving miRNA and miRNA inhibitor molecules
#2846Vectors and methods for genetic immunization
#2847Methods and compositions involving miRNA and miRNA inhibitor molecules
#2848Methods for creating bilayers for use with nanopore sensors
#2849Methods and compositions for the production of siRNAs
#2850Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#2851Methods for cleaving a target DNA using a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein
#2852Oligomeric compounds and compositions for the use in modulation of micrornas
#2853Formulations for treating amyloidosis
#2854Post-synthetic orthogonal amidation plus metal catalyzed azide-alkyne cycloaddition click chemistry on siRNA
#2855Compositions and methods for functional nucleic acid delivery
#2856Methods and compositions of improved modified siRNA
#2857Production of therapeutic proteins in genetically modified mammalian cells
#2858Multimeric oligonucleotide compounds having non-nucleotide based cleavable linkers
#2859Signal activatable constructs and related components compositions methods and systems
#2860Method of rapidly inducing large-scale and high-purity mesenchymal stem cells to transdetermine into hematopoietic stem cells
#2861Compositions and methods for polynucleotide transfection
#2862Double-stranded ribonucleic acid for adjuvants
#2863RNA interference agent, method for producing same, and use therefor
#2864Competitive modulation of microRNAs
#2865Construction of pool of interfering nucleic acids covering entire RNA target sequence and related compositions
#2866In vivo gene silencing by chemically modified and stable siRNA
#2867Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor
#2868MICROMIRs
#2869Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (GVHD)
#2870Cell capable of producing adeno-associated virus vector
#2871Diagnosis and treatment of endometriosis
#2872Therapeutics with conformationally restricted monomers
#2873Modified cytosine polynucleotide oligomers and methods
#2874RIG-I ligands and methods for producing them
#2875Delivery of dsRNA to arthropods
#2876Oligonucleotide conjugates
#2877Inhibiting migration of cancer cells
#2878Triazine cationic polymers and methods of use thereof
#2879Lipidosome preparation, preparation method and application thereof
#2880Antisense antiviral compound and method for treating ss/RNA viral infection
#2881RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#2882Oligomeric compounds comprising bicyclic nucleosides and uses thereof
#2883NUCLEASE RESISTANT POLYNUCLEOTIDES AND USES THEREOF
#2884Lipids and compositions for the delivery of therapeutics
#2885Gene silencing methods
#2886Nucleic acid functionalized nonoparticles for therapeutic applications
#2887Use of miR-221 and 222 lowering agents to prevent cardiovascular disease in diabetic subjects
#2888Human toll-like receptor inhibitors and methods of use thereof
#2889RNA trans-splicing molecule (RTM) for use in the treatment of cancer
#2890Piggy back delivery of nucleic acids into organisms
#2891Biotin complexes for treatment and diagnosis of alzheimer's disease
#2892Asymmetric ionizable cationic lipid for RNA delivery
#2893Ionizable cationic lipid for RNA delivery
#2894Polynucleotides having bioreversible groups
#2895Antisense polynucleotides to induce exon skipping and methods of treating dystrophies
#2896Selective reactivation of genes on the inactive X chromosome
#2897Biosensors for detecting macromolecules and other analytes
#2898Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
#2899Synthetic promoter for modulating gene expression
#2900Compositions for the delivery of RNA and drugs into cells
#2901Exosome-based therapeutics against neurodegenerative disorders
#2902Chiral control
#2903Use of monosaccharide-like glycylated sugar alcohol compositions for designing and developing anti-diabetic drugs
#2904CTLA-4 aptamer siRNA species
#2905Exosomes and micro-ribonucleic acids for tissue regeneration
#2906Co-transcriptional assembly of modified RNA nanoparticles
#2907Aminoalcohol lipidoids and uses thereof
#2908Compositions for targeted delivery of siRNA
#2909Multi-conjugate of siRNA and preparing method thereof
#2910RNA aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells
#2911Structurally designed shRNAs
#2912Modified RNAi agents
#2913Oligonucleotides for making a change in the sequence of a target RNA molecule present in a living cell
#2914Methods and compositions for treating prostate cancer
#2915Recombinant DNA for gene suppression
#2916Ligand-conjugated monomers
#2917Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy
#2918Methods for genomic integration
#2919Bacteria mediated gene silencing
#2920Oligomeric compounds comprising bicyclic nucleotides and uses thereof
#2921Nucleic acids for down-regulation of gene expression
#2922Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use
#2923Antisense nucleic acids
#2924Compositions and methods for inhibition of nucleic acids function
#2925Particle-nucleic acid conjugates and therapeutic uses related thereto
#2926Low density lipoprotein receptor-mediated siRNA delivery
#2927Lipid formulations for nucleic acid delivery
#2928Vector for the selective silencing of a gene in astrocytes
#2929Methods, systems, and compositions for cell-derived/vesicle-based microrna delivery
#2930Chemical modification of short small hairpin RNAs for inhibition of gene expression
#2931siRNA compounds comprising terminal substitutions
#2932Sugar chain-containing polymer, and sugar chain-containing polymer complex
#2933Constructs for diagnosing and treating inflammatory bowel diseases and colon cancer
#2934Ionizable cationic lipid for RNA delivery
#2935Charge conversional ternary polyplex
#2936RNA interference mediating small RNA molecules
#2937Inhibitors of microRNAs that regulate production of atrial natriuretic peptide (ANP) as therapeutics and uses thereof
#2938Diester and triester based low molecular weight, biodegradeable cationic lipids for oligonucleotide delivery
#2939Methods and compositions useful for diagnosing inflammatory bowel disease-associated neoplasia
#2940High complexity siRNA pools
#2941Method for rapidly evaluating performance of short interfering RNA with novel chemical modifications
#2942Compositions and methods for modulating apolipoprotein (a) expression
#2943Compositions and methods for modulating apolipoprotein C-III expression
#2944Conjugated antisense compounds and their use
#2945Gene targeting methods and tools
#2946Nucleic acid fragment binding to target protein
#2947Method for constructing functional nucleic acid molecule, and nucleic acid combination to be used in said method
#2948Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules
#2949RNA-interference-inducing nucleic acid molecule able to penetrate into cells, and use therefor
#2950Composition for gene delivery
#2951Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#2952Interfering RNA molecules
#2953Multi-targeting short interfering RNAs
#2954MicroRNA compounds and methods for modulating miR-122
#2955Compositions and methods for gene silencing
#2956Rational design of microRNA-siRNA chimeras for multi-functional target suppression
#2957Method of regulating gene expression
#2958RNA-interference by single-stranded RNA molecules
#2959Block copolymer, liquid composite thereof, nucleic acid preparation, preparation methods therefor, and use thereof
#2960Use of aptamers in proteomics
#2961Lipid-derived neutral nanoparticles
#2962Methods and compositions for translational profiling and molecular phenotyping
#2963Genetic correction of mutated genes
#2964iRNA agents with biocleavable tethers
#2965Micro-RMA inhibitor
#2966Methods for genome-wide screening and construction of genetic interaction maps
#2967Methods and kits for synthesis of siRNA expression cassettes
#2968RNAi molecule delivery platform based on single-siRNA and shRNA nanocapsules
#2969Functionalized fluorine containing phthalocyanine molecules
#2970Glycoconjugates of RNA interference agents
#2971Method for detecting target substance, assay kit, and detection apparatus
#2972High molecular weight arginine-grafted bioreducible polymers
#2973Double-stranded oligonucleotides
#2974Dually derivatized chitosan nanoparticles and methods of making and using the same
#2975Nucleic acid enzyme substrates
#2976Delivery of dsRNA to arthropods
#2977Trans-acting RNA switches
#2978Extended dicer substrate agents and methods for the specific inhibition of gene expression
#2979Extended dicer substrate agents and methods for the specific inhibition of gene expression
#2980Esophageal microRNA expression profiles in eosinophilic esophagitis
#2981Precursor miRNA loop-modulated target regulation
#2982MiRNA analysis methods
#2983Compounds and methods for enhanced cellular uptake
#2984Vitamin B6-coupled poly(ester amine) as gene carrier and application in cancer gene therapy
#2985Aptamer regulated nucleic acids and uses thereof
#2986Embryonic stem cell specific microRNAs promote induced pluripotency
#2987Targeting RNAs to microvesicles
#2988Oligomer-conjugate complexes and their use
#2989Double-stranded and single-stranded RNA molecules with 5′ Triphosphates and their use for inducing interferon
#2990Arginine-based lipids for delivery of therapeutics
#2991Modifications for antisense compounds
#2992Internal reference genes for microRNAs normalization and uses thereof
#2993Cancer diagnostics using non-coding transcripts
#2994Use of microrna molecules to influence skin pigmentation
#2995CRLF-2 BINDING PEPTIDES, PROTOCELLS AND VIRAL-LIKE PARTICLES USEFUL IN THE TREATMENT OF CANCER, INCLUDING ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
#2996High-efficiency nanoparticle-type double-helical oligo-RNA structure and method for preparing same
#2997Methods and compositions for reducing viral genome amounts in a target cell
#2998Lipid particle, nucleic acid transfer carrier, compound for manufacturing nucleic acid transfer carrier, method for manufacturing lipid particle, and gene transfer method
#2999Small conditional RNAs
#3000Methods for developing binding-elements and uses thereof