109047 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof General methods applicable to biologically active non-coding nucleic acids
SYSTEM FOR IMPROVED DELIVERY OF GENE MODULATING COMPOUNDS
#3302Uniform Field Magnetization and Targeting of Therapeutic Formulations
#3303Short hairpin RNAs for inhibition of gene expression
#3304Methods and compositions for reducing viral genome amounts in a target cell
#3305THERAPEUTIC AGENT FOR FIBROID LUNG
#3306Modified siRNA molecules and uses thereof
#3307Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
#3308Kits comprising linear DNAs for sustained polypeptide expression using synthetic, modified RNAs
#3309Kit for making induced pluripotent stem cells using modified RNAs
#3310Compositions and Methods for Inhibiting Expression of a Mutant Gene
#3311Duplex oligonucleotide complexes and methods for gene silencing by RNA interference
#3312Antisense antiviral compound and method for treating ssRNA viral infection
#3313METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF SINGLE AND DOUBLE BLUNT-ENDED siRNA
#3314Modulation of pre-mRNA using splice modulating oligonucleotides as therapeutic agents in the treatment of disease
#3315Method of identifying myelodysplastic syndromes
#3316Low density lipoprotein receptor-mediated siRNA delivery
#3317Delivery of dsRNA to arthropods
#3318Supercoiled minivectors for gene therapy applications
#3319Methods for identifying drug effects on a cell by determining changes in the cell's spliced message profile
#3320Morpholino-based antisense agent
#3321AGENTS, COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIES IN WHICH REGULATING AN ACHE-ASSOCIATED BIOLOGICAL PATHWAY IS BENEFICIAL
#3322Proinflammatory nucleic acids
#3323Modulating Gene Expression With agRNA and Gapmers Targeting Antisense Transcripts
#3324Reduction of off-target RNA interference toxicity
#3325Method of inhibiting miR-33 using a modified oligonucleotide
#3326siRNA Targeting Glucagon Receptor (GCCR)
#3327Sirna compounds comprising terminal substitutions
#3328siRNA targeting amyloid beta (A4) precursor protein (APP)
#3329Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes
#3330Cochleate compositions directed against expression of proteins
#3331Bi-specific digoxigenin binding antibodies
#3332Means and methods for the specific modulation of target genes in the CNS and the eye and methods for their identification
#3333CONTROL OF GENE EXPRESSION
#3334Localized Delivery of Gold Nanoparticles for Therapeutic and Diagnostic Applications
#3335Nucleic acid-containing lipid particles and related methods
#3336Identification of RNAI targets and use of RNAI for rational therapy of chemotherapy-resistant leukemia and other cancers
#3337SiRNA targeting apolipoprotein (APOB)
#3338Antisense molecules and methods for treating pathologies
#3339Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
#3340siRNA Targeting Diacylglycerol O-Acyltransferase Homolog 2 (DGAT2)
#3341Alternative export pathways for vector expressed RNA interference
#3342Methods of sequencing fluorophore-quencher FRET-aptamers
#3343Method of inducing an immune response
#3344Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent
#3345SiRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
#3346Method for introducing siRNA into cells by photochemical internalisation
#3347OLIGOMERIC COMPOUNDS AND EXCIPIENTS
#3348MicroRNA affinity assay and uses thereof
#3349Single molecule nucleic acid nanoparticles
#3350MULTIPLEX DICER SUBSTRATE RNA INTERFERENCE MOLECULES HAVING JOINING SEQUENCES
#3351Modular aptamer-regulated ribozymes
#3352Molecule for treating an inflammatory disorder
#3353Duplex oligonucleotides with enhanced functionality in gene regulation
#3354siRNA targeting kinase insert domain receptor (KDR)
#3355siRNA Targeting Proto-oncogene MET
#3356Systems and methods for individualized functional genomic profiling related to cancer cell growth
#3357Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#3358METHOD OF DELIVERING RNA INTERFERENCE AND USES THEREOF
#3359Delivery System and Conjugates For Compound Delivery Via Naturally Occurring Intracellular Transport Routes
#3360Inducible small RNA expression constructs for targeted gene silencing
#3361Method of regulating gene expression
#3362NOVEL CATIONIC LIPIDS WITH SHORT LIPID CHAINS FOR OLIGONUCLEOTIDE DELIVERY
#3363Trans-acting RNA switches
#3364Methods for delivery of siRNA to the spinal cord and therapies arising therefrom
#3365siRNA Targeting Interleukin-1 Receptor-associated Kinase 4 (IRAK4)
#3366Method for rapidly evaluating performance of short interfering RNA with novel chemical modifications
#3367RNA-INTERFERENCE BY SINGLE-STRANDED RNA MOLECULES
#3368Oligonucleotide derivative comprising an aromatic compound
#3369Minor groove binder (MGB)-oligonucleotide miRNA antagonists
#3370COMPOSITIONS AND METHODS FOR DELIVERING RNAI USING APOE
#3371Methods and systems for identifying micro-RNA targets and synthesizing novel micro-RNAs and uses of the same
#3372Methods for increasing efficacy of lipid formulated siRNA
#3373IMMUNIZATION STRATEGY TO PREVENT H1N1 INFECTION
#3374INDUCIBLE SYSTEMS AND METHODS FOR CONTROLLING siRNA EXPRESSION
#3375NOVEL SIRNA STRUCTURE FOR MINIMIZING OFF-TARGET EFFECTS AND RELAXING SATURATION OF RNAI MACHINERY AND THE USE THEREOF
#3376Amphiphilic nucleotide cochleate compositions and methods of using the same
#3377Polyconjugates for in vivo delivery of polynucleotides
#3378Methods of Modulating the Sex of Avians
#3379Compositions and methods for inhibiting expression of transthyretin
#3380Viral and viral associated mirnas and uses thereof
#3381SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS
#3382Methods and compositions for improved deliver, expression or activity of RNA interference agents
#3383AGENTS USEFUL IN TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY
#3384Cancer Specific Mitotic Network
#3385siRNA targeting catenin, Beat-1 (CTNNB1)
#3386Methods of running assays using intrachain fluorophore-quencher FRET-aptamers
#3387MicroRNA Signatures Differentiating Uterine and Ovarian Papillary Serous Tumors
#3388METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASE
#3389Method of regulating the expression level of survival of motor neuron 1
#3390Methods for Diagnosing Stomach Cancer Using MicroRNA Signatures
#3391Methods for Diagnosing Prostate Cancer Using MicroRNA Signatures
#3392Methods for diagnosing lung cancer using MicroRNA signatures
#3393Methods for diagnosing colon cancer using MicroRNA signatures
#3394Methods for Diagnosing Breast Cancer Using MicroRNA Signatures
#3395Methods for diagnosing stomach cancer using MicroRNAs
#3396Methods for diagnosing prostate cancer using MicroRNAs
#3397Methods for diagnosing pancreatic cancer using MicroRNAs
#3398Methods for diagnosing lung cancer using microRNAs
#3399Methods for diagnosing colon cancer using MicroRNAs
#3400Methods for diagnosing breast cancer using MicroRNAs
#3401Methods for diagnosing pancreatic cancer using miR-103-1, miR-103-2, miR-24-2 and miR-107
#3402Methods for Diagnosing Breast Cancer Using miR-21, miR-125-1, miR-125b-2 and miR-145
#3403Methods for Diagnosing Colon, Stomach, Prostate and Pancreas Cancer Using miR-223
#3404Methods for Diagnosing Breast and Lung Cancer Using miR-210 and miR-213
#3405Methods for diagnosing breast, colon, lung, pancreatic and prostate cancer using miR-21 and miR-17-5p
#3406COMPOSITIONS AND METHODS FOR MODULATING STEM CELLS AND USES THEREOF
#3407Bridged artificial nucleoside and nucleotide
#3408REPROGRAMMING COMPOSITIONS AND METHODS OF USING THE SAME
#3409Cationic lipids and methods for the delivery of therapeutic agents
#3410CELL IMAGING METHOD FOR VIEWING MICRORNA BIOGENESIS IN THE CELLS
#3411Liposomes comprising a calcium phosphate-containing precipitate
#3412MODULATION OF IMMUNOSTIMULATORY PROPERTIES OF OLIGONUCLEOTIDE-BASED COMPOUNDS BY UTILIZING MODIFIED IMMUNOSTIMULATORY DINUCLEOTIDES
#3413Methods and products for expression of micro RNAs
#3414MODULATION OF SGLT-2 EXPRESSION
#3415Selecting and stabilizing dsRNA constructs
#3416Method and means for treatment of osteoarthritis
#3417METHOD FOR DETERMINING THE PRESENCE AND CONCENTRATION OF ANALYTES USING A NUCLEIC ACID LIGAND AND RARE EARTH ELEMENTS
#3418Polynucleotides for multivalent RNA interference, compositions and methods of use thereof
#3419SiRNA targeting connective tissue growth factor (CTGF)
#3420Construction of bifunctional short hairpin RNA
#3421Lipid formulations for nucleic acid delivery
#3422SPLICE VARIANTS
#3423siRNA phospholipid conjugate
#3424BIOENGINEERED SILK PROTEIN-BASED NUCLEIC ACID DELIVERY SYSTEMS
#3425METHODS FOR THE IDENTIFICATION OF MICRORNA AND THEIR APPLICATIONS IN RESEARCH AND HUMAN HEALTH
#3426HPV particles and uses thereof
#3427STRONGLY BOUND BASE-MODIFIED OLIGONUCLEOTIDES
#3428Chemical modification of short small hairpin RNAs for inhibition of gene expression
#3429Peptide-based in vivo siRNA delivery system
#3430General composition framework for ligand-controlled RNA regulatory systems
#3431Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#3432Vector utilizing borna disease virus and use thereof
#3433PHARMACEUTICAL COMPOSITION FOR TREATING ADVERSE REACTIONS DUE TO ADMINISTRATION OF SPIEGELMERS
#3434NUCLEIC ACID MOLECULES AND USES THEREOF
#3435TRICYCLO-DNA ANTISENSE OLIGONUCLEOTIDES, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE
#3436Short-chain cationic polyamino acid and use thereof
#3437Methods and compositions for seamless cloning of nucleic acid molecules
#3438Targeting Kidney Mesangium With Nanoparticles of Defined Diameter
#3439Targeting Kidney Mesangium With Nanoparticles of Defined Diameter
#3440Sphingosine-bound siRNA
#3441Multi-Cistronic shRNA Expression Cassette for Suppressing Single or Multiple Target Genes
#3442NUCLEIC ACID DELIVERY COMPOSITIONS AND METHODS OF USE THEREOF
#3443SOLUBLE THF RECEPTORS AND THEIR USE IN TREATMENT OF DISEASE
#3444NON HUMAN ANIMAL MODELS FOR INCREASED RETINAL VASCULAR PERMEABILITY
#3445Modified siNA
#3446METHODS FOR EVALUATING GASTROINTESTINAL ABSORPTION OF CHEMICALS
#3447Use of DR6 and p75 antagonists to promote survival of cells of the nervous system
#3448SiRNA targeting catenin, beta-1 (CTNNB1)
#3449HYBRID INTERFERING RNA
#3450siRNA targeting spleen tyrosine kinase
#3451METHODS FOR SCREENING AND IDENTIFYING COMPOUNDS
#3452Embryonic stem cell specific microRNAs promote induced pluripotency
#3453Modified antisense oligopeptides with anticancer properties and method of obtaining them
#3454Lipophilic polynucleotide conjugates
#3455Gene vector
#3456Delivery method
#3457Therapeutic nucleic acid-3′-conjugates
#3458Mannose-6-phosphate receptor mediated gene transfer into muscle cells
#3459Long-Acting DNA Dendrimers and Methods Thereof
#3460METHODS AND COMPOSITIONS FOR REDUCING TARGET GENE EXPRESSION USING COCKTAILS OF siRNAS OR CONSTRUCTS EXPRESSING siRNAS
#3461Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#3462METHODS AND KITS TO GENERATE miRNA- AND SMALL RNA-EXPRESSING VECTORS, AND ITS APPLICATION TO DEVELOP LENTIVIRAL EXPRESSION LIBRARIES
#3463RNA sequence-specific mediators of RNA interference
#3464SMALL INTERFERING RNA DELIVERY
#3465COMPOSITIONS AND METHODS FOR IMMUNOSTIMULATORY RNA OLIGONUCLEOTIDES
#3466Means And Methods For Counteracting, Preventing And/Or Determining Heart Failure, Or A Risk Of Heart Failure
#3467Sirna Compositions Promoting Scar-Free Wound Healing of Skin and Methods for Wound Treatment
#3468Oligomeric compounds and compositions for the use in modulation of target nucleic acids
#3469PEPTIDE/PARTICLE DELIVERY SYSTEMS
#3470CARBON NANOTUBES COMPLEXED WITH MULTIPLE BIOACTIVE AGENTS AND METHODS RELATED THERETO
#3471Mesenchymal Stem Cells Producing Inhibitory RNA for Disease Modification
#3472Cand45 tRNA-Derived Expression System for Gene Modulation
#3473COMPOSITIONS AND METHODS FOR PREPARING SHORT RNA MOLECULES AND OTHER NUCLEIC ACIDS
#3474siRNA conjugate and preparation method thereof
#3475Modifications for Antisense Compounds
#3476Methods and compositions to protect aquatic invertebrates from disease
#3477DOUBLE-STRANDED OLIGONUCLEOTIDES
#3478AMPHOTERIC LIPOSOMAL COMPOSITIONS FOR CELLULAR DELIVERY OF SMALL RNA MOLECULES FOR USE IN RNA INTERFERENCE
#3479METHOD OF RAPIDLY PRODUCING IMPROVED VACCINES FOR ANIMALS
#3480GEMM RIBOSWITCHES, STRUCTURE-BASED COMPOUND DESIGN WITH GEMM RIBOSWITCHES, AND METHODS AND COMPOSITIONS FOR USE OF AND WITH GEMM RIBOSWITCHES
#3481NUCLEIC ACID DELIVERY COMPOUNDS
#3482Transducible delivery of nucleic acids using modified dsRNA binding domains
#3483Methods for Inducing Mixed Chimerism
#3484COMPOSITIONS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY NUCLEIC ACID CONTAINING A DICER SUBSTRATE AND A RECEPTOR BINDING REGION
#3485METHODS FOR PRODUCING INTERFERING RNA MOLECULES IN MAMMALIAN CELLS AND THERAPEUTIC USES FOR SUCH MOLECULES
#3486NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS
#3487MicroRNAs and uses thereof
#3488Devices, systems and methods for improving memory and/or cognitive function through brain delivery of siRNA
#3489Compositions for bacterial mediated gene silencing and methods of using same
#3490Anti-connexin compounds targeted to connexins and methods of use thereof
#3491Modified oligonucleotide and its preparation and application
#3492Anti viral therapy
#3493Method for using ref protein as a targeted reca-dependent nuclease
#3494OLIGONUCLEOTIDE MICELLES
#3495Methods for producing microRNAs
#3496Human serum albumin-siRNA nano-sized carrier system
#3497Non-Viral Transfection Agent
#3498High Throughput Assay for Cancer Cell Growth Inhibition
#3499Methods of determining potency of chemically-synthesized oligonucleotides
#3500Polyion complex of double-stranded ribonucleic acid
#3501Vector
#3502Nanoparticles for Extravascular Administration
#3503Tetrahydropyran nucleic acid analogs
#3504TOPICAL THERAPEUTIC AGENT FOR OPHTHALMIC DISEASES COMPRISING COMPOUND CAPABLE OF BINDING SPECIFICALLY TO DNA SEQUENCE
#3505DNA virus MicroRNA and methods for inhibiting same
#3506METHODS AND COMPOSITIONS FOR TREATING CANCER
#3507SiRNA targeting apolipoprotein B (APOB)
#3508Methods and compositions involving miRNA and miRNA inhibitor molecules
#3509MODULATING IRES-MEDIATED TRANSLATION
#3510RNA MOLECULES AND THERAPEUTIC USES THEREOF
#3511RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
#3512Polymeric nano-particles for siRNA delivery using charge interaction and covalent bonding
#3513Lipids, lipid complexes and use thereof
#3514Methods for regulating neural differentiation
#3515Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor
#3516Therapeutic and diagnostic strategies
#3517RNAi expression constructs
#3518Adenoviral VA1 Pol III expression system for RNAi expression
#3519Lipids and compositions for the delivery of therapeutics
#3520Reengineering mRNA primary structure for enhanced protein production
#3521Cationic poly (amino acids) and uses thereof
#3522METHODS AND COMPOSITIONS FOR SELECTING SIRNA OF IMPROVED FUNCTIONALITY
#3523METHOD OF DELIVERY OF NUCLEIC ACIDS TO A DEVELOPING EMBRYO
#3524Expression of apoAI and variants thereof using spliceosome mediated RNA -splicing
#3525Compositions, kits, and methods for making induced pluripotent stem cells using synthetic modified RNAs
#3526Multi-targeting short interfering RNAs
#3527OLIGONUCLEOTIDE COMPRISING AN INOSINE FOR TREATING DMD
#3528Down regulation of the gene expression by means of nucleic acid-loaded virus-like particles
#3529DENDRIMER-LIKE MODULAR DELIVERY VECTOR
#3530Delivery of dsRNA to arthropods
#3531DESIGN OF SMALL-INTERFERING RNA
#3532PROTEIN TARGETS IN DISEASE
#3533Target substance detection method using aptamer
#3534ISOLATION OF FACTORS THAT ASSOCIATE DIRECTLY OR INDIRECTLY WITH CHROMATIN
#3535miRNA TARGETS
#3536Ribonucleic acid interference molecules
#3537Reduced size self-delivering RNAi compounds
#3538TREATMENT OF RADIATION-INDUCED FIBROSIS
#3539Method for inhibiting the activity of mir-155
#3540Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
#3541Aptamer regulated nucleic acids and uses thereof
#3542Methods and kits for miRNA isolation and quantitation
#3543RNA sequence-specific mediators of RNA interference
#3544MULTIPLE RNA POLYMERASE III PROMOTER EXPRESSION CONSTRUCTS
#3545METHODS AND COMPOSITIONS RELATING TO POLYPEPTIDES WITH RNASE III DOMAINS THAT MEDIATE RNA INTERFERENCE
#3546Lipids and compositions for the delivery of therapeutics
#3547FOLATE TARGETING OF NUCLEOTIDES
#3548Signal activated molecular delivery
#3549Means for inhibiting the expression of ANG2
#3550Structurally designed shRNAs
#3551SMALL INTERFERENCE RNA COMPLEX WITH INCREASED INTRACELLULAR TRANSMISSION CAPACITY
#3552Compositions And Methods For Increasing Cellular Uptake Of RNAi Via SID-1
#3553Phagocytic cell delivery of RNAI
#3554siRNA targeting Superoxide
#3555RNA sequence-specific mediators of RNA interference
#3556Single-stranded nucleic acid molecule for controlling gene expression
#3557SiRNA targeting myeloid differentiation primary response gene (88) (MYD88)
#3558Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity
#3559Targeted delivery system
#3560METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR THE DIAGNOSIS AND TREATMENT OF DISEASES INVOLVING INFLAMMATION
#3561Single walled carbon nanotube/sirna complexes and methods related thereto
#3562siRNA targeting cyclin-dependent kinase 4 (CDK4)
#3563Cell-specifically effective molecules on the basis of siRNA and application kits for the production thereof and use thereof
#3564siRNA targeting gremlin
#3565SiRNA targeting histamine receptor H1
#3566Method to trigger RNA interference
#3567METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#3568HDL particles for delivery of nucleic acids
#3569RNAI BASED SELECTION SYSTEM
#3570Lipids and compositions for the delivery of therapeutics
#3571Lipids and compositions for the delivery of therapeutics
#3572Method and materials for the cooperative hybridization of oligonucleotides
#3573STABILIZATION METHOD OF FUNCTIONAL NUCLEIC ACID
#3574RNA interference mediating small RNA molecules
#3575Antisense EGFRAS guanidinium peptide nucleic acid (GPNA) oligonucleotides as antitumor agents
#3576COMPOSITIONS AND METHODS FOR EX VIVO HEPATIC NUCLEIC ACID DELIVERY
#3577BRANCHED CATIONIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEM
#3578Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization
#3579Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#3580METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#3581RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#3582RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#3583MODIFIED snRNAs FOR USE IN THERAPY
#3584COMPOSITIONS AND METHODS FOR COMBINED THERAPY OF DISEASE
#3585Recombinant DNA constructs encoding ribonuclease cleavage blockers and methods for modulating expression of a target gene
#3586LIPIDS, LIPID COMPLEXES AND USE THEREOF
#3587Sensizitation of cancer cells to therapy using sina targeting genes from the 1P and 19Q chromosomal regions
#3588Expression system
#3589CHIMERIC THERAPEUTICS, COMPOSITIONS, AND METHODS FOR USING SAME
#3590Aminoalcohol lipidoids and uses thereof
#3591RNA sequence-specific mediators of RNA interference
#3592Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#3593PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
#3594Triggered covalent probes for imaging and silencing genetic expression
#3595Compositions and methods for the specific inhibition of gene expression by DSRNA containing a tetraloop
#3596NUCLEIC ACID DELIVERY COMPOSITIONS AND METHODS
#3597Simplified method for partial genetic and epigenetic reprogramming of cells using siRNA specific for a heterochromatin protein 1
#3598Compositions and methods for inhibiting expression of a mutant gene
#3599Polynucleotide aptamer-based cross-linked materials and uses thereof
#3600RNA sequence-specific mediators of RNA interference