109054 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides against enzymes
Apoptosis Inducer for Cancer Cell
#3602Inhibition of HIV replication and expression of p24 with eIF-5A
#3603MODULATION OF ACE2 EXPRESSION
#3604Compositions and methods for inhibiting the synthesis or expression of MMP-1
#3605Modulation of innate immunity receptors' signaling by microRNAs miR-146a and miR-146b
#3606COMPOSITIONS AND METHODS FOR INHIBITING TUMOR GROWTH AND METASTASIS
#3607Method and composition for treating and preventing tumor metastasis in vivo
#3608Inhibition of Syk kinase expression
#3609Small interfering RNA specific to sub-units α, α′and β of the Kinase Protein ck2, and the applications of the same
#3610Method for identifying drug-sensitizing antisense DNA fragments and use thereof
#3611Inhibitors of dynein or lissencephaly 1, and methods of using same for treatment of neuronal disorders
#3612Nucleic Acid Molecules As Herpanase Potent Inhibitors, Compositions And Methods Of Use Thereof
#3613Functional and hyperfunctional siRNA
#3614EGVII endoglucanase and nucleic acids encoding the same
#3615Adenosine therapy via interfering RNA
#3616Induction of apoptosis by inhibition of sirtuin SIRT1 expression
#3617Methods and compositions for vitamin K epoxide reductase
#3618Regulatory segments of the human gene for telomerase reverse transcriptase
#3619RNA interference mediated inhibition of histone deacetylase (HDAC) gene expression using short interfering nucleic acid (siNA)
#3620Modulation of ace2 expression
#3621Sirna based methods for treating alzheimer's disease
#3622Use of RNAI inhibiting PARP activity for the manufacture of a medicament for the treatment of cancer
#3623Hedgehog Kinases and Their Use in Modulating Hedgehog Signaling
#3624MODIFIED POLYNUCLEOTIDES FOR USE IN RNA INTERFERENCE
#3625Treatment of tumor with dnazyme directed to peroxiredoxin
#3626Modified polynucleotides for use in rna interference
#3627Detection of PKC-iota as a biomarker for brain tumorigenesis
#3628RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER'S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA)
#3629Drug for preventing and treating atherosclerosis
#3630Treatment of neurodegenerative diseases by the use of laptm4b
#3631Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
#3632Pharmaceutical composition
#3633Detection of mutations in a gene associated with resistance to viral infection, OAS1
#3634RNAi-mediated inhibition of RHO kinase for treatment of ocular disorders
#3635ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF JNK PROTEINS
#3636Methods and compositions for RNA interference
#3637siRNA targeting spleen tyrosine kinase
#3638Sirna mediated post-transriptional gene silencing of genes involved in alopecia
#3639Method for controlling SR protein phosphorylation, and antiviral agents whose active ingredients comprise agents that control SR protein activity
#3640Process for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase
#3641Double-stranded RNA oligonucleotides which inhibit tyrosinase expression
#3642Inhibition of gene expression by delivery of polynucleotides to animal cells in vivo
#3643Posh polypeptides, complexes and related methods
#3644Telomerase-inhibiting ENA oligonucleotide
#3645Methods for slowing familial ALS disease progression
#3646Methods of modulating cell cycle and cell signaling pathways using biliverdin reductase
#3647Method for activating T cell protein tyrosine phosphatase for therapeutic applications
#3648Dbait and uses thereof
#3649Inhibition of histone deacetylase
#3650Laccases, nucleic acids encoding them and methods for making and using them
#3651siRNA targeting carbonic anhydrase II
#3652Methods and means for inhibiting fever
#3653Sirt4 activities
#3654siRNA targeting MCL1
#3655Medical treatment
#3656Rna interference mediated inhibition of xiap gene expression using short interfering nucleic acid (sina)
#3657Regulation of food intake by modulation of long-chain fatty acyl-CoA levels in the hypothalamus
#3658siRNA targeting tumor necrosis factor superfamily member 1A
#3659siRNA targeting complement factor B
#3660siRNA targeting BCL2L1
#3661siRNA targeting KRAS
#3662Method of identifying agents that inhibit the growth of cancer cells
#3663Methods of treatment and diagnosis using modulators of virus-induced cellular gene sequences
#3664Therapeutic methods, compounds and compositions
#3665Therapeutic compounds
#3666siRNA targeting survivin
#3667Antisense modulation of superoxide dismutase 1, soluble expression
#3668Modulation of s6 kinase activity for the treatment of obesity
#3669RNA interference mediated inhibition of 11 beta-hydroxysteroid dehydrogenase-1 (11 beta-HSD-1) gene expression using short interfering nucleic acid siNA
#3670Antisense antibacterial method and compound
#3671METHOD FOR INHIBITING TELOMERASE ACTIVITY
#3672Gp131: methods and compositions for treating cancer
#3673Functional and hyperfunctional siRNA
#3674Oligonucleotide N3'-P5' thiophosphoramidates: their synthesis and use
#3675Modulation of hair growth
#3676Production of reprogrammed cells with restored potential
#3677Therapy for Alzheimer's disease
#3678Vector utilizing ribonuclease reductase UTR and use for inhibiting neoplastic cells
#3679Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina)
#3680Methods for inducing differentiation of undifferentiated mammalian cells into osteoblasts
#3681Functional and hyperfunctional siRNA
#3682Methods and compositions for silencing genes without inducing toxicity
#3683GLUCOSE TRANSPORT-RELATED GENES, POLYPEPTIDES, AND METHODS OF USE THEREOF
#3684Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies
#3685Modulation of SOCS-3 expression
#3686Inhibition of Lysyl oxidase for treating tumor growth and diagnostics relating thereto
#3687Antisense antibacterial method and compound
#3688Modulation of endothelial lipase expression
#3689Methods and compositions for RNA interference
#3690Antiviral oligonucleotides having a conserved G4 core sequence
#3691Modulation of endogenous AICAR levels for the treatment of diabetes and obesity
#3692Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
#3693Methods and compositions for the inhibition of stat5 in prostate cancer cells
#3694Methods and compositions for vitamin K epoxide reductase
#3695Antibody against nox1 polypeptide, method of diagnosing cancer with the use of nox1 gene and method of screening cancer growth inhibitor
#3696Diagnosis and treatment of kidney fibrosis and other fibrotic diseases
#3697Methods for modulating bone tissue formation, orthogenic agents and pharmaceutical compositions
#3698Antisense modulation of superoxide dismutase 1, soluble expression
#3699Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
#3700Methods and reagents for inhibiting cell proliferation
#3701Oligonucleotides comprising a non-phosphate backbone linkage
#3702Animal models for demyelination disorders
#3703Nucleic acids encoding inactive variants of human telomerase
#3704Mule: Mcl-1 ubiquitination ligase E3
#3705Inhibitors of ribonucleotide reductase subunit 2 and uses thereof
#3706Combined therapy utilizing reduction of DNA methyltransferase expression and/or activity and interferon
#3707Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis
#3708Adeno-associated virus-delivered ribozyme compositions and methods of use
#3709Rna interference mediated treatment of alzheimer's disease using short interfering nucleic acid (sina)
#3710Antisense oligonucleotides directed to ribonucleotide reductase r2 and uses thereof in the treament of cancer
#3711Means for preventing and treating cellular death and their biological applications
#3712Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin K epoxide reductase gene and warfarin dosage
#3713Methods and compositions for the treatment of eye disorders with increased intraocular pressure
#3714Small interference RNA (siRNA) molecules for modulating superoxide dismutase (SOD)
#3715Inhibition of SHIP to enhance stem cell harvest and transplantation
#3716Chemically modified double stranded nucleic acid molecules that mediate RNA interference
#3717RNA interference mediated inhibition of checkpoint kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)
#3718Diagnosis and treatment of malignant neoplasms
#3719Inhibition of E3-ubiquitin ligase HAKAI for treatment of proliferative disorders
#3720Antisense oligonucleotide against human acetylcholinesterase (AChE) and uses thereof
#3721Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
#3722Ribozyme therapy for the treatment of proliferative skin and eye diseases
#3723Inhibiting HER2 shedding with matrix metalloprotease antagonists
#3724RNAi-mediated inhibition of ocular targets
#3725RNAi-mediated inhibition of ocular hypertension targets
#3726Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
#3727Polynucleotides targeted against the extended 5′-UTR region of argininosuccinate synthase and uses thereof
#3728Oligonucleotide inhibitors of MBD2/DNA demethylase and uses thereof
#3729NADPH oxidase inhibition pharmacotherapies for obstructive sleep apnea syndrome and its associated morbidities
#3730Enzymatic nucleic acid treatment of diseases or conditions related to levels of IKK-gamma and PKR
#3731RNA interference mediated inhibition of histone deacetylase (HDAC) gene expression using short interfering nucleic acid (siNA)
#3732Method of evaluating compound efficacious in treating obesity
#3733Inhibition of stress-induced ligand-dependent egfr activation
#3734Antisense oligonucleotide modulation of raf gene expression
#3735Methods and compositions concerning siRNA's as mediators of RNA interference
#3736RNA interference mediated inhibition of cyclin dependent kinase-2 (CDK2) gene expression using short interfering nucleic acid (siNA)
#3737Selective inhibition of rock1 in cardiac therapy
#3738EGVII endoglucanase and nucleic acids encoding the same
#3739Combinations of antisense oligonucleotides directed against thymidylate synthase mrna and uses thereof
#3740EGVII endoglucanase and nucleic acids encoding the same
#3741Allele-specific RNA interference
#3742Amino-LNA, thio-LNA and alpha-L-oxy-LN
#3743RNA interference mediated inhibition of MAP kinase gene expression or expression of genes involved in MAP kinase pathway using short interfering nucleic acid (siNA)
#3744Methods and compositions for treating cellular proliferative diseases
#3745Aptamer-mediated intracellular delivery of therapeutic oligonucleotides
#3746Antisense modulation of hydroxysteroid 11-beta dehydrogenase 1 expression
#3747Modulation of deubiquitinase family members
#3748Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
#3749Antisense oligonucleotides for identifying drug targets and enhancing cancer therapies
#3750RNA interference in respiratory epitheial cells
#3751Conjugates for use in hepatocyte free uptake assays
#3752Methods of reducing an immune response
#3753In vivo inhibition of hepatitis B virus
#3754AKT3 inhibitors
#3755Oligoribonucleotides for the treatment of degenerative skin conditions by RNA interference
#3756RNAi-based therapeutics for allergic rhinitis and asthma
#3757Antisense modulation of hematopoietic cell protein tyrosine kinase expression
#3758ADAR1 antiviral pathway
#3759Antisense oligonucleotides directed to genes regulated by trapoxin-induced HDAC inhibition
#3760Antibody to telomerase reverse transcriptive
#3761Methods for modulating lipoprotein and cholesterol levels in humans
#3762Methods for reducing or preventing localized fibrosis using SiRNA
#3763Ceramide kinase and uses thereof
#3764Treatment of neurological disorders by dsrna administration
#3765Composition and method for introduction of RNA interference sequences into targeted cells and tissues
#3766Antisense modulation of PTP1B expression
#3767Methods of inhibiting COX-2
#3768Methods of inhibiting manganese-containing superoxide dismutase 2 (MnSOD)
#3769RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
#3770RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA)
#3771Inhibition of tumor growth and invasion by anti-matrix metalloproteinase DNAzymes
#3772RNA interference mediated inhibtion of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
#3773Cell transfecting formulations of small interfering RNA related compositions and methods of making and use
#3774Medical devices and methods for delivering compositions to cells
#3775Methods and compositions for enhancing delivery of double-stranded RNA or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells
#3776Double-stranded oligonucleotides
#3777siRNA-Mediated gene silencing with viral vectors
#3778Cre-lox based method for conditional RNA interference
#3779Methods and compositions for treating gain-of-function disorders using RNA interference
#3780Compositions and methods for treating neoplastic disease using chemotherapy and radiation sensitizers
#3781Antisense modulation of ptpn12 expression
#3782Methods, compositions and compound assays for inhibiting amyloid-beta protein production
#3783Function of autophagy genes in cell death
#3784Antisense oligonucleotides against thymidylate synthase
#3785SiRNA targeting PI3K signal transduction pathway and siRNA-based therapy
#3786Modulation of diacylglycerol acyltransferase 2 expression
#3787Vitamin K epoxide recycling polypeptide VKORC1, a therapeutic target of coumarin and their derivatives
#3788Materials and methods for the alteration of enzyme and acetyl CoA levels in plants
#3789Modulation of Aurora B expression
#3790Antisense modulation of p70 S6 kinase expression
#3791Combinatorial methods and compositions for treatment of melanoma
#3792Syk-targeted nucleic acid interference
#3793Intranasal delivery of nucleic acid molecules
#3794Method of increasing endogenous adiponectin and leptin production
#3795Oligoribonucleotides for the treatment of irritative or inflammatory skin symptoms through RNA interference
#3796RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering RNA
#3797Dilation introducer for orthopedic surgery
#3798RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA)
#3799Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents
#3800Methods and compositions for selecting siRNA of improved functionality
#3801Use of immunomodulating agents
#3802FcγRIIA-specific nucleic acid interference
#3803Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents
#3804Functional and hyperfunctional siRNA
#3805Functional and hyperfunctional siRNA directed against Bcl-2
#3806Engineered rnai adenovirus silencing expression (erase) of dna reair proteins
#3807SiRNA delivery into mammalian nerve cells
#3808RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)
#3809Method of inhibiting collagen formation by VDUP1 inhibition
#3810RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA)
#3811Modulation of kallikrein 6 expression
#3812Modified polynucleotides for reducing off-target effects in RNA interference
#3813Polycationic compositions for cellular delivery of polynucleotides
#3814Methylenetetrahydrofolate reductase inhibitors and use thereof
#3815BGL3 beta-glucosidase and nucleic acids encoding the same
#3816Hepatocyte free uptake assays
#3817Cancer associated protein kinases and their uses
#3818Modulation of tyrosinase expression
#3819BGL3 beta-glucosidase and nucleic acids encoding the same
#3820RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)
#3821RNA interference mediated inhibition of 11beta hydroxysteriod dehydrogenase-1 (11beta HSD-1) gene expression
#3822Inhibition of calcium-independent phospholipases A2beta or A2gamma inhibit hormone-induced differentiation of 3T3-L1 preadipocytes
#3823Cytoplasmic inhibition of gene expression
#3824RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA)
#3825Transcription factor RNA interference reagents and methods of use thereof
#3826Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases
#3827Antisense modulation of dual specific phosphatase 5 expression
#3828Methods and compositions for blocking progression of a disease state
#3829RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acis (siNA)
#3830RNA interference mediated inhibition of checkpoint Kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)
#3831Antisense antibacterial cell division composition and method
#3832Antisense oligonucleotides and RNA-interfering molecules targeting PAK4
#3833RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
#3834RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
#3835Compositions and their uses directed to cell growth and maintenance proteins
#3836Antisense modulation of EIF2C1 expression
#3837RNA interference mediated inhibition of NF-Kappa B / REL-A gene expression using short interfering nucleic acid (siNA)
#3838RNA interference mediated inhibition of protein kinase C alpha (PKC-alpha) gene expression using short interfering nucleic acid (siNA)
#3839RNA interference mediated inhibition of GPRA and AAA1 gene expression using short interfering nucleic acid (siNA)
#3840RNA interference mediated inhibition of cholinergic muscarinic receptor (CHRM3) gene expression using short interfering nucleic acid (siNA)
#3841RNA interference mediated inhibition of protein tyrosine phosphatase type IVA (PRL3) gene expression using short interfering nucleic acid (siNA)
#3842Polymearase III-based expression of therapeutic RNAs
#3843RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA)
#3844RNA interference mediated inhibition of epidermal growth factor receptor (EGFR) gene expression using short interfering nucleic acid (siNA)
#3845Compositions and their uses directed to binding proteins
#3846RNA interference mediated inhibition of cholesteryl ester transfer protein (CEPT) gene expression using short interfering nucleic acid (siNA)
#3847RNA interference mediated inhibition of 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA)
#3848RNA interference mediated inhibition of ADAM33 gene expression using short interfering nucleic acid (siNA)
#3849RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA)
#3850RNA interference mediated inhibition of type 1 insulin-like growth factor receptor gene expression using short interfering nucleic acid (siNA)
#3851Methods of using mammalian RNase H and compositions thereof
#3852Hepatocyte free uptake assays
#3853RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA)
#3854RNA interference mediated inhibition of chromosome translocation gene expression using short interfering nucleic acid (siNA)
#3855RNA interference mediated inhibition of angiopoietin gene expression using short interfering nucleic acid (siNA)
#3856RNA interference mediated inhibition of gastric inhibitory polypeptide (GIP) and gastric inhibitory polypeptide receptor (GIPR) gene expression using short interfering nucleic acid (siNA)
#3857RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)
#3858RNA interference mediated inhibition 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA)
#3859Methods for eliminating or reducing the expression of a genes in a filamentous fungal strains
#3860RNA interference mediated inhibition of proliferating cell nuclear antigen (PCNA) gene expression using short interfering nucleic acid (siNA)
#3861Methods of using mammalian RNase H and compositions thereof
#3862Oligonucleotide compositions and methods for treating disease including inflammatory conditions
#3863RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA)
#3864Antisense modulation of extracellular-signal-regulated kinase-6 expression
#3865Human RNase H and compositions and uses thereof
#3866DNA enzyme to inhibit plasminogen activator inhibitor-1
#3867Therapeutic compounds
#3868RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
#3869Antisense modulation of phospholipase A2, group IIA (synovial) expression
#3870RNA interference mediated target discovery and target validation using short interfering nucleic acid (siNA)
#3871si-RNA-mediated gene silencing technology to inhibit tyrosinase and reduce pigmentation
#3872Antisense inhibition via RNAse H-independent reduction in mRNA
#3873RNA interference mediated inhibition of wingless gene expression using short interfering nucleic acid (siNA)
#3874RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA)
#3875RNA interference mediated inhibition of acetyl-CoA-carboxylase gene expression using short interfering nucleic acid (siNA)
#3876RNA interference mediated inhibition of TRPM7 gene expression using short interfering nucleic acid (siNA)
#3877RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA)
#3878Diagnosis and treatment of malignant neoplasms
#3879Conjugated oligomeric compounds and their use in gene modulation
#3880RNA mediated inhibition connexin gene expression using short interfering nucleic acid (siNA)
#3881Diagnosis and treatment of malignant neoplasms
#3882Modified oligonucleotides for telomerase inhibition
#3883Modulation of line-1 reverse transcriptase
#3884Antisense modulation of inducible nitric oxide synthase expression
#3885Antisense modulation of polo-like kinase expression
#3886Antisense modulation of caspase 7 expression
#3887Modulation of phosphodiesterase 4B expression
#3888Compositions and methods for the treatment of severe acute respiratory syndrome (SARS)
#3889Adeno-associated virus-delivered ribozyme compositions and methods for the treatment of retinal diseases
#3890Antisense modulation of PTP1B expression
#3891Delivery of dsRNA to arthropods
#3892RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA)
#3893Modulation of aminopeptidase N expression
#3894Inhibition of Syk kinase expression
#3895RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
#3896Antisense modulation of wrn espression
#3897Antisense modulation of ptpn2 expression
#3898RNA interference mediated inhibtion of tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
#3899Identifying and testing antisense oligonucleotides that inhibit telomerase reverse transcriptase
#3900Antisense modulation of acyl coenzyme a cholesterol acyltransferase-1 expression