109104 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression; Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
MOUSE MODEL OF DITRA DISEASE AND USES THEREOF
#2POMPE DISEASE MOUSE MODEL GENERATION, CHARACTERIZATION AND METHODS OF USE
#3ACOUSTICALLY-DRIVEN BUFFER SWITCHING FOR MICROPARTICLES
#4GENETICALLY MODIFIED NON-HUMAN ANIMALS WITH HUMANIZED IMMUNOGLOBULIN AND MHC LOCI
#5GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC NKP46
#6TRANSGENIC MICE WITH HUMANIZED MHC I AND IMMUNOGLOBLUIN HEAVY CHAIN GENES
#7TRANSGENIC MICE WITH HUMANIZED MHC I AND IMMUNOGLOBLUIN HEAVY CHAIN GENES
#8VECTORS, GENETICALLY MODIFIED CELLS, AND GENETICALLY MODIFIED NON-HUMAN ANIMALS COMPRISING THE SAME
#9PRIMATE DISEASE MODEL CONSTRUCTION METHOD BASED ON FAST GENE EDITION
#10RODENT ANMALS EXPRESSING HUMAN CR1
#11METHODS AND COMPOSITIONS FOR INSERTION OF ANTIBODY CODING SEQUENCES INTO A SAFE HARBOR LOCUS
#12Method for Constructing Murine Model with Mutations in Csf1r Gene and Application thereof
#13LONG GERMLINE DH GENES AND LONG HCDR3 ANTIBODIES
#14METHODS AND COMPOSITIONS FOR THE TARGETED MODIFICATION OF A GENOME
#15MOUSE MODEL FOR BIO-IMAGING OF INFLAMMATORY SIGNALS, PREPARATION METHOD THEREFOR AND USE THEREOF
#16LAMC2-NR6A1 Splicing Variant and Translation Product Thereof
#17Method of using a genetically modified mouse that expresses human albumin
#18HUMANIZED IL-15 ANIMALS
#19MOUSE MODEL OF DITRA DISEASE AND USES THEREOF
#20GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD94 AND/OR NKG2A
#21TRANSCRIPTION MODULATION IN ANIMALS USING CRISPR/CAS SYSTEMS
#22OBSESSIVE-COMPULSIVE DISORDER ANIMAL MODEL AND PRODUCTION METHOD THEREOF
#23CGAS/DNCV-LIKE NUCLEOTIDYLTRANSFERASES AND USES THEREOF
#24Rodent animals expressing human CR1
#25USE OF ECM1 GENE-KNOCKOUT MOUSE IN SCREENING OF ANTI-HEPATIC FIBROSIS DRUG
#26NON-HUMAN ANIMALS EXPRESSING HUMANIZED C1Q COMPLEX
#27Novel Animal Model For Laing Distal Myopathy (Mpd1) And Methods of Use Thereof
#28GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GENES
#29TCR libraries
#30METHOD FOR FAST GENE EDITING AND CONSTRUCTING PRIMATE DISEASE MODEL
#31METHODS FOR PREVENTING AND TREATING TYPE II DIABETES
#32Non-human animals models of retinoschisis
#33Targeted modification of rat genome
#34NON-HUMAN ANIMALS CAPABLE OF DH-DH REARRANGEMENT IN THE IMMUNOGLOBULIN HEAVY CHAIN CODING SEQUENCES
#35Non-human animals having a humanized signal-regulatory protein gene
#36Isolation of novel AAV's and uses thereof
#37Genetically modified rat that expresses an F54L Txn1 mutant
#38NON-HUMAN ANIMALS HAVING A HUMANIZED A PROLIFERATION-INDUCING LIGAND GENE
#39Humanized knock-in mouse expressing human Protein C
#40Liver lesion-mouse model
#41GENETICALLY MODIFIED NON-HUMAN ANIMALS FOR GENERATING THERAPEUTIC ANTIBODIES AGAINST PEPTIDE-MHC COMPLEXES, METHODS OF MAKING AND USES THEREOF
#42Genetically modified non-human animal with human or chimeric genes
#43INDUCIBLE DISEASE MODELS METHODS OF MAKING THEM AND USE IN TISSUE COMPLEMENTATION
#44Genetically modified mouse that expresses human albumin
#45Methods for preventing and treating type II diabetes
#46METHODS AND COMPOSITIONS FOR INSERTION OF ANTIBODY CODING SEQUENCES INTO A SAFE HARBOR LOCUS
#47Methods and compositions for the targeted modification of a genome
#48P21-Activated Kinase Inhibitor Domain Targeted Transgenic Mouse
#49Non-human animals having a humanized signal-regulatory protein gene
#50Humanized IL-15 animals
#51Cell model for in vitro evaluation of compound-induced skin sensitization and a constructing method therefor
#52COMPOSITIONS AND METHODS FOR CONTROLLING PAIN
#53Mouse model of DITRA disease and uses thereof
#54Transgenic mice with inducible neuron-specific inactivation of HuR gene and method of screening
#55Development of YY male fish broodstocks in a single generation
#56Method for constructing PD-1 gene modified humanized animal model and use thereof
#57Targeted modification of rat genome
#58Acoustically-Driven Buffer Switching for Microparticles
#59GENETICALLY MODIFIED NON-HUMAN ANIMALS FOR GENERATING THERAPEUTIC ANTIBODIES AGAINST PEPTIDE-MHC COMPLEXES, METHODS OF MAKING AND USES THEREOF
#60Transcription modulation in animals using CRISPR/Cas systems
#61Isolation of novel AAV's and uses thereof
#62Method of using a transgenic mouse with alpha-one antitrypsin (ATT) deficiency to screen compounds
#63Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells
#64Long germline DH genes and long HCDR3 antibodies
#65Non-human animals having a humanized signal-regulatory protein gene
#66Methods and compositions for the targeted modification of a mouse ES cell genome
#67Non-human animals expressing humanized C1Q complex
#68GENOME EDITING IN RATS USING ZINC-FINGER NUCLEASES
#69TCR libraries
#70INDUCIBLE DISEASE MODELS METHODS OF MAKING THEM AND USE IN TISSUE COMPLEMENTATION
#71TRANSGENIC MICE
#72INHIBITING GENE EXPRESSION WITH dsRNA
#73High-throughput mouse model for optimizing antibody affinities
#74METHOD FOR PREPARING A CANINE MODEL OF ATHEROSCLEROSIS
#75Method for generating a humanized transgenic mouse comprising a human APRIL gene
#76Non-human animal models of retinoschisis
#77Opto-genetic modulator
#78Non-human animals having a humanized signal-regulatory protein gene
#79Nucleic acid construct with a p16 promoter that causes a prodrug converting enzyme to be expressed specifically in senescent cells
#80ANIMAL MODEL HAVING HYPOPARATHYROIDISM AND METHOD FOR PRODUCING THE SAME
#81Transgenic mouse model for dementia
#82Humanized IL-15 animals
#83Transgenic animal for visualization of ATP and use thereof
#84A METHOD OF SITE-DIRECTED INSERTION TO H11 LOCUS IN PIGS BY USING SITE-DIRECTED CUTTING SYSTEM
#85STERILE MALE INSECTS THAT SIGNIFICANTLY REDUCE LIFESPAN AND EGG-PRODUCTION OF MATED WILD-TYPE FEMALE INSECTS
#86ANIMAL MODEL FOR NEPHROPATHY AND AGENTS FOR TREATING THE SAME
#87P21-activated kinase inhibitor domain targeted transgenic mouse
#88Mouse model of alpha-one antitrypsin (AAT) deficiency
#89TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS WITH SK CHANNEL ACTIVATORS
#90Non-human animals having a humanized signal-regulatory protein gene
#91Targeted modification of rat genome
#92Isolation of novel AAV's and uses thereof
#93Isolation of novel AAV's and uses thereof
#94GENETICALLY MODIFIED NON-HUMAN MAMMALS HAVING MODIFIED LIVER CELLS AND/OR TISSUE AND METHODS OF MAKING SAME
#95INHIBITING GENE EXPRESSION WITH dsRNA
#96Methods and compositions for the targeted modification of a mouse embryonic stem cell genome
#97Non-human animals having a humanized signal-regulatory protein gene
#98High-throughput mouse model for optimizing antibody affinities
#99Transgenic non-human mammal that expresses human MMP2
#100Immunocompromised ungulates
#101Compositions and methods for controlling pain
#102Transgenic mice expressing human pyrin domain only protein 2
#103HETEROZYGOUS MODIFICATIONS OF TUMOR SUPPRESSOR GENES
#104Isolation of novel AAV's and uses thereof
#105GENOME EDITING IN RATS USING ZINC-FINGER NUCLEASES
#106Non-human animals having a humanized signal-regulatory protein gene
#107Model animal for pregnancy-induced hypertension syndrome, and treatment method therefor
#108Methods and compositions for the targeted modification of a genome
#109Methods and compositions for the targeted modification of a mouse genome
#110TRANSGENIC MOUSE MODELS FOR MC4R
#111Humanized IL-15 animals
#112Non human animal model for ulcerative colitis and its main complications
#113METHOD AND MATERIALS FOR PRODUCING A GENETICALLY MODIFIED ANIMAL
#114Immunocompromised Ungulates
#115Genetically engineered or transgenic rats exhibiting a cancer phenotype due to a disruption of germline tumor suppressor genes
#116Method of deleting an IgM gene in an isolated rat cell
#117Isolation of novel AAV'S and uses thereof
#118Method for producing a transgenic pig using a hyper-methylated transposon
#119Inhibiting Gene Expression with dsRNA
#120Inhibiting Gene Expression with dsRNA