ClassID:

109173

C12N2310/3231 - page 2 - CPC Classification

Classification description:

Structure or type of the nucleic acid; Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA

Recent Application in this class:
#301
20230330128
2023-10-19

OLIGOMERS HAVING BICYCLIC SCAFFOLD MOIETIES

#302
20230323421
2023-10-12

OLIGONUCLEOTIDES TARGETING XBP1

#303
20230323362
2023-10-12

COMPLEMENT COMPONENT C1R INHIBITORS FOR TREATING A NEUROLOGICAL DISEASE, AND RELATED COMPOSITIONS, SYSTEMS AND METHODS OF USING SAME

#304
20230323349
2023-10-12

Targeting enhancer RNAs for the treatment of primary brain tumors

#305
20230323345
2023-10-12

UNA OLIGOMERS FOR THE TREATMENT OF POLYGLUTAMINE DISEASES

#306
20230323344
2023-10-12

Polynucleotides containing a morpholino linker

#307
20230323343
2023-10-12

CLOSED LINEAR DNA WITH MODIFIED NUCLEOTIDES

#308
20230322840
2023-10-12

BRIDGED NUCLEOSIDE AND NUCLEOTIDE

#309
20230321255
2023-10-12

Modulators of PCSK9 Expression

#310
20230313189
2023-10-05

COMPLEMENT COMPONENT 4 INHIBITORS FOR TREATING NEUROLOGICAL DISEASES, AND RELATED COMPOSITONS, SYSTEMS AND METHODS OF USING SAME

#311
20230296587
2023-09-21

Oligonucleotides for inducing paternal UBE3A expression

#312
20230295629
2023-09-21

ANTI-C9ORF72 OLIGONUCLEOTIDES AND RELATED METHODS

#313
20230287420
2023-09-14

Compositions and methods of treating facioscapulohumeral muscular dystrophy

#314
20230287412
2023-09-14

Oligonucleotide Agonists Targeting Progranulin

#315
20230279396
2023-09-07

Oligomeric Compounds Comprising Bicyclic Nucleotides and Uses Thereof

#316
20230279395
2023-09-07

Compositions and methods of treating Facioscapulohumeral muscular dystrophy

#317
20230272403
2023-08-31

ANTISENSE OLIGONUCLEOTIDE INDUCING EXON SKIPPING OF ANGIOTENSIN CONVERTING ENZYME 2 GENE

#318
20230265439
2023-08-24

COMBINATORIAL INHIBITION OF TRANSCRIPTION FACTORS FOR TREATMENT OF HEART FAILURE

#319
20230265436
2023-08-24

THERAPEUTICS FOR SYNGAP HAPLOINSUFFICIENCY

#320
20230265428
2023-08-24

Modulators of APOL1 expression

#321
20230265426
2023-08-24

COMBINATORIAL INHIBITION OF MIRNAS FOR TREATMENT OF HEART FAILURE

#322
20230235381
2023-07-27

Compositions of matter for detection assays

#323
20230235332
2023-07-27

TREATMENT OF NEUROLOGICAL DISEASES USING MODULATORS OF GENE TRANSCRIPTS

#324
20230235331
2023-07-27

COMPOUNDS AND METHODS FOR REDUCING MSH3 EXPRESSION

#325
20230235322
2023-07-27

RNA EDITING INHIBITORS AND METHODS OF USE

#326
20230212572
2023-07-06

Guanosine Analogues for Use in Therapeutics Polynucleotides

#327
20230212564
2023-07-06

METHODS AND COMPOSITIONS FOR MODULATING ALPHA-1-ANTITRYPSIN EXPRESSION

#328
20230203492
2023-06-29

ANTISENSE THERAPEUTICS FOR BETACORONAVIRUS TREATMENT

#329
20230203491
2023-06-29

DOUBLE-STRANDED OLIGONUCLEOTIDE AND COMPOSITION FOR TREATING COVID-19 CONTAINING SAME

#330
20230201243
2023-06-29

MODULATORS OF FOXP3 EXPRESSION

#331
20230193286
2023-06-22

CYTOTOXIC T-LYMPHOCYTE BINDING APTAMERS

#332
20230193285
2023-06-22

BISPECIFIC PERSONALIZED APTAMERS

#333
20230193269
2023-06-22

OLIGONUCLEOTIDES FOR SPLICE MODULATION OF CARD9

#334
20230193263
2023-06-22

USE OF SBDS INHIBITORS FOR TREATING HEPATITIS B VIRUS INFECTION

#335
20230193260
2023-06-22

Antisense oligonucleotides targeting alpha-synuclein and uses thereof

#336
20230183708
2023-06-15

PD-1-specific antisense oligonucleotide and its use in therapy

#337
20230183705
2023-06-15

PRODUCTS FOR SUPPRESSING OR REDUCING THE EXPRESSION OR ACTIVITY OF A SNORNA AND USES THEREOF IN THE TREATMENT OF CANCER

#338
20230183701
2023-06-15

Modified double-stranded RNA agents

#339
20230183689
2023-06-15

Compositions and Methods for Genome Editing

#340
20230174989
2023-06-08

Methods and Compositions for the ADAR-Mediated Editing of ABCA4

#341
20230174987
2023-06-08

Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression

#342
20230174982
2023-06-08

ENGINEERED NUCLEIC ACIDS AND USES THEREOF

#343
20230174980
2023-06-08

CHANNEL MODULATORS

#344
20230167450
2023-06-01

BIFUNCTIONAL MOLECULES AND METHODS OF USING THEREOF

#345
20230159925
2023-05-25

ANTISENSE OLIGONUCLEOTIDE OF CALM2

#346
20230151365
2023-05-18

COMPOSITIONS AND METHODS FOR MODULATING TTR EXPRESSION

#347
20230139322
2023-05-04

SiRNA molecule inhibiting the expression of the PCSK9 gene and use thereof

#348
20230132093
2023-04-27

EXTRACELLULAR VESICLE-NLRP3 ANTAGONIST

#349
20230127437
2023-04-27

ANTISENSE OLIGONUCLEOTIDE OF ATN1

#350
20230126157
2023-04-27

MIRNA-485 INHIBITOR FOR GENE UPREGULATION

#351
20230122751
2023-04-20

USE OF COPS3 INHIBITORS FOR TREATING HEPATITIS B VIRUS INFECTION

#352
20230121967
2023-04-20

Oligomeric Compounds Comprising Bicyclic Nucleotides and Uses Thereof

#353
20230118177
2023-04-20

COMPOSITIONS AND METHODS FOR MODULATING GROWTH HORMONE RECEPTOR EXPRESSION

#354
20230118138
2023-04-20

USE OF SCAMP3 INHIBITORS FOR TREATING HEPATITIS B VIRUS INFECTION

#355
20230114429
2023-04-13

Oligomeric compounds for reducing DMPK expression

#356
20230113863
2023-04-13

Selective Antisense Compounds and Uses Thereof

#357
20230113497
2023-04-13

Nucleic acid molecule for reduction of PAPD5 and PAPD7 mRNA for treating hepatitis B infection

#358
20230112920
2023-04-13

Compositions for Modulating C9ORF72 Expression

#359
20230110876
2023-04-13

MODIFIED DOUBLE-STRANDED RNA AGENTS

#360
20230109466
2023-04-06

Compositions for treatment of polycystic kidney disease

#361
20230105319
2023-04-06

PRODRUG INCORPORATED sgRNA SYNTHESIS

#362
20230098111
2023-03-30

COMPOSITIONS AND METHODS TO TREAT NEUROLOGICAL DISEASES

#363
20230095566
2023-03-30

ANTI-ADAM33 OLIGONUCLEOTIDES AND RELATED METHODS

#364
20230090531
2023-03-23

Compositions of matter for detection assays

#365
20230090446
2023-03-23

ANTISENSE OLIGONUCLEOTIDE TARGETING LINC00518 FOR TREATING MELANOMA

#366
20230089915
2023-03-23

PRODUCTS AND COMPOSITIONS

#367
20230079754
2023-03-16

Methods and compositions for reducing pathogenic isoforms

#368
20230072073
2023-03-09

Pan-Genotypic Agents Against Influenza Virus and Methods of Using the Same

#369
20230068063
2023-03-02

Modified compounds and uses thereof

#370
20230061732
2023-03-02

STABLE TARGET-EDITING GUIDE RNA HAVING CHEMICALLY MODIFIED NUCLEIC ACID INTRODUCED THEREINTO

#371
20230054941
2023-02-23

INHIBITION OF DENND5B EXPRESSION FOR TREATING HEPATIC STEATOSIS

#372
20230054720
2023-02-23

Antisense Oligonucleotides Targeting ATXN3

#373
20230049529
2023-02-16

MODIFIED DOUBLE STRANDED OLIGONUCLEOTIDE

#374
20230040829
2023-02-09

COMPOSITIONS AND METHODS FOR MODULATING ATAXIN 3 EXPRESSION

#375
20230029227
2023-01-26

Tunable Reversir™ compounds

#376
20230020545
2023-01-19

Methods for reactivating genes on the inactive X chromosome

#377
20230020092
2023-01-19

COMPOSITIONS FOR DELIVERY OF ANTISENSE COMPOUNDS

#378
20230018254
2023-01-19

EXTRACELLULAR VESICLES WITH ANTISENSE OLIGONUCLEOTIDES TARGETING KRAS

#379
20230002770
2023-01-05

IL-34 ANTISENSE AGENTS AND METHODS OF USING SAME

#380
20230002763
2023-01-05

Selective antisense compounds and uses thereof

#381
20230002762
2023-01-05

OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE

#382
20220411800
2022-12-29

RNA MOLECULE, CHIMERIC NA MOLECULE, DOUBLE-STRANDED RNA MOLECULE, AND DOUBLE-STRANDED CHIMERIC NA MOLECULE

#383
20220404347
2022-12-22

METHODS FOR DETECTING AN ANALYTE USING STRUCTURE SWITCHING BINDING AGENTS

#384
20220403393
2022-12-22

Modulation of Angiopoietin-Like 3 Expression

#385
20220403388
2022-12-22

Oligonucleotide Progranulin Agonists

#386
20220403386
2022-12-22

Selective reduction of allelic variants

#387
20220403380
2022-12-22

RNA Interactome of Polycomb Repressive Complex 1 (PRC1)

#388
20220389424
2022-12-08

Modified double-stranded RNA agents

#389
20220389420
2022-12-08

AGENTS FOR THE TREATMENT OF PATIENTS WITH NSCLC AND METHODS TO PREDICT RESPONSE

#390
20220372482
2022-11-24

Modified antisense oligonucleotide for inhibition of FoxP3 expression

#391
20220372476
2022-11-24

Dynamic pharmacokinetic-modifying anchors

#392
20220364096
2022-11-17

Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof

#393
20220364086
2022-11-17

ANTISENSE OLIGONUCLEOTIDE CAPABLE OF ALTERING SPLICING OF DUX4 pre-mRNA

#394
20220363706
2022-11-17

5`S-LNA nucleotides and oligonucleotides

#395
20220348916
2022-11-03

COMPOSITION FOR DIAGNOSIS OR TREATMENT OF A CONDITION ASSOCIATED WITH INCREASED ACTIVITY OF EIF4E COMPRISING AN EIF4E INHIBITOR

#396
20220340908
2022-10-27

METHODS FOR DEPLETION OF DELETERIOUS MITOCHONDRIAL GENOMES

#397
20220333111
2022-10-20

ANTI-MIRNAS FOR THE TREATMENT OF LEIOMYOMA

#398
20220331351
2022-10-20

Nucleic acids for inhibiting expression of TMPRSS6 and iron chelators

#399
20220324984
2022-10-13

NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF

#400
20220307028
2022-09-29

COMPOSITIONS AND METHODS FOR MITIGATION OF ISCHEMIC REPERFUSION INJURY

#401
20220307024
2022-09-29

DELIVERY OF OLIGONUCLEOTIDES TO THE STRIATUM

#402
20220307019
2022-09-29

DOUBLE-STRANDED NUCLEIC ACID COMPLEX AND USE THEREOF

#403
20220290149
2022-09-15

METHOD OF DETECTION OF FIBRIN CLOTS

#404
20220290146
2022-09-15

Compounds and methods for modulating ATXN1

#405
20220290137
2022-09-15

COMPOUNDS AND METHODS FOR REDUCING SPDEF EXPRESSION

#406
20220282251
2022-09-08

COMPOSITIONS AND METHODS FOR DETECTING AND TREATING INSULIN RESISTANCE

#407
20220282249
2022-09-08

COMPOUNDS AND METHODS USEFUL FOR MODULATING GENE SPLICING

#408
20220275365
2022-09-01

COMPOSITIONS AND METHODS FOR MODULATING TTR EXPRESSION

#409
20220267762
2022-08-25

CLOSED LOOP CONTINUOUS APTAMER DEVELOPMENT SYSTEM

#410
20220265862
2022-08-25

COMPOSITIONS AND METHODS FOR THE TREATMENT OF LEUKODYSTROPHY AND WHOLE ANIMAL AND CELLULAR MODELS FOR IDENTIFYING EFFICACIOUS AGENTS FOR TREATMENT OF THE SAME

#411
20220259601
2022-08-18

UBE3A ANTISENSE THERAPEUTICS

#412
20220259600
2022-08-18

COMPOUNDS AND METHODS FOR MODULATING TMPRSS6 EXPRESSION

#413
20220259589
2022-08-18

REVERSIR™ compounds

#414
20220251556
2022-08-11

Enhanced oligonucleotides for inhibiting RTEL1 expression

#415
20220251553
2022-08-11

Methods and compositions for inhibiting PMP22 expression

#416
20220243210
2022-08-04

ANGIOTENSIN II TYPE 1 RECEPTOR TARGETED OLIGONUCLEOTIDES AND USES THEREOF

#417
20220243209
2022-08-04

Modulators of Complement Factor B

#418
20220243204
2022-08-04

TREATMENT OF HEART FAILURE IN HUMAN SUBJECTS

#419
20220243200
2022-08-04

COMPOSITIONS AND METHODS FOR MODULATING TAU EXPRESSION

#420
20220243198
2022-08-04

Pan-Genotypic Agents Against Influenza Virus and Methods of Using the Same

#421
20220228206
2022-07-21

LINKED TARGET CAPTURE

#422
20220228152
2022-07-21

OLIGONUCLEOTIDE THERAPY FOR WOLMAN DISEASE AND CHOLESTERYL ESTER STORAGE DISEASE

#423
20220228140
2022-07-21

COMPOUND, METHOD AND PHARMACEUTICAL COMPOSITION FOR MODULATING EXPRESSION OF DUX4

#424
20220220485
2022-07-14

PD-L1 antisense oligonucleotides for use in tumor treatment

#425
20220220484
2022-07-14

METHODS AND COMPOSITIONS OF SHORT SMALL HAIRPIN RNAS AND MICRORNAS FOR WOUND HEALING

#426
20220213484
2022-07-07

ANGPTL2 ANTISENSE OLIGONUCLEOTIDES AND USES THEREOF

#427
20220213483
2022-07-07

METHODS FOR TREATMENT OF POLYCYSTIC KIDNEY DISEASE

#428
20220213477
2022-07-07

Therapeutic Targeting of a microRNA to Treat Duchenne Muscular Dystrophy

#429
20220213476
2022-07-07

Oral delivery of antisense conjugates targeting PCSK9

#430
20220204973
2022-06-30

Antisense oligonucleotide for targeting progranulin

#431
20220204971
2022-06-30

Compositions and Methods for Inhibiting Cancers and Viruses

#432
20220195497
2022-06-23

HYBRIDIZING all-LNA OLIGONUCLEOTIDES

#433
20220195439
2022-06-23

TREATMENT OF GLIAL CELL DERIVED NEUROTROPHIC FACTOR (GDNF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO GDNF

#434
20220195433
2022-06-23

RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)

#435
20220195430
2022-06-23

Compositions for modulating Ataxin 2 expression

#436
20220195428
2022-06-23

OLIGONUCLEOTIDES AND METHODS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION

#437
20220194972
2022-06-23

Novel Process for Preparing Rhenium Chelated MAG3 Oligonucleotides

#438
20220184216
2022-06-16

INTRACELLULAR TARGETING OF MOLECULES

#439
20220177888
2022-06-09

Modified short interfering nucleic acid (siNA) molecules and uses thereof

#440
20220177884
2022-06-09

Oligonucleotides for modulating Tau expression

#441
20220177883
2022-06-09

Antisense Oligonucleotides Targeting ATXN3

#442
20220177880
2022-06-09

DOUBLE-STRANDED NUCLEIC ACID INHIBITOR MOLECULES WITH SHORTENED SENSE STRANDS

#443
20220170024
2022-06-02

ANTISENSE-INDUCED EXON2 INCLUSION IN ACID ALPHA-GLUCOSIDASE

#444
20220170023
2022-06-02

Modulation of prekallikrein (PKK) expression

#445
20220162613
2022-05-26

ANGPTL4 oligonucleotides influencing the regulation of the fatty acid metabolism

#446
20220162607
2022-05-26

NUCLEIC ACID COMPLEX FOR MODULATING IHH EXPRESSION

#447
20220162597
2022-05-26

Compound for treatment of heart failure

#448
20220160880
2022-05-26

ANTISENSE NUCLEIC ACID TARGETING PCSK9

#449
20220154182
2022-05-19

ANTISENSE OLIGONUCLEOTIDE-BASED PROGRANULIN AUGMENTATION THERAPY IN NEURODEGENERATIVE DISEASES

#450
20220146496
2022-05-12

Oligonucleotides for inducing paternal UBE3A expression

#451
20220145302
2022-05-12

TARGETS AND METHODS FOR TREATING EPSTEIN-BARR VIRUS MEDIATED NEURODEGENERATION

#452
20220145295
2022-05-12

ENZYMATIC RNA SYNTHESIS

#453
20220143064
2022-05-12

TAU ANTISENSE OLIGOMERS AND USES THEREOF

#454
20220133767
2022-05-05

TARGETING MICRORNAS TO OVERCOME DRUG TOLERANCE AND RESISTANCE

#455
20220127610
2022-04-28

OLIGONUCLEOTIDES FOR USE IN THE TREATMENT OF DYSTROPHIC EPIDERMOLYSIS BULLOSA

#456
20220127607
2022-04-28

METHODS AND MATERIALS FOR ACTIVATING AN INTERNAL RIBOSOME ENTRY SITE IN EXON 5 OF THE DMD GENE

#457
20220127604
2022-04-28

REVERSIR TM COMPOUNDS

#458
20220119817
2022-04-21

Polycomb-associated Non-Coding RNAs

#459
20220119816
2022-04-21

NOVEL TARGET TO TREAT A METABOLIC DISEASE IN AN INDIVIDUAL

#460
20220119812
2022-04-21

MICRO RNA INTERACTIONS AS THERAPEUTIC TARGETS FOR COVID-19 AND OTHER VIRAL INFECTIONS

#461
20220119811
2022-04-21

ALPHA-SYNUCLEIN ANTISENSE OLIGONUCLEOTIDES AND USES THEREOF

#462
20220119439
2022-04-21

5'-Cyclo-Phosphonate Modified Nucleotides

#463
20220112493
2022-04-14

PHOSPHONOACETATE GAPMER OLIGONUCLEOTIDES

#464
20220098595
2022-03-31

NR2E3 EXPRESSION REDUCING OLIGONUCLEOTIDES, COMPOSITIONS CONTAINING THE SAME, AND METHODS OF THEIR USE

#465
20220098588
2022-03-31

METHODS FOR CONTROLLING SEIZURES BY MANIPULATING THE LEVELS OF MICRORNA-211 (miR-211) IN THE BRAIN

#466
20220098586
2022-03-31

OLIGONUCLEOTIDE

#467
20220098583
2022-03-31

MicroRNA Compounds and Methods for Modulating MIR-21 Activity

#468
20220098581
2022-03-31

Methods for Oral Delivery of Oligonucleotides

#469
20220090082
2022-03-24

Gapmer antisense oligonucleotides targeting SARS-CoV-2 for treating COVID 19

#470
20220090079
2022-03-24

Methods and compositions for managing vascular conditions using miR-483 mimics and HIF1alpha pathway inhibitors

#471
20220089632
2022-03-24

Bicyclic nucleosides and oligomers prepared therefrom

#472
20220073923
2022-03-10

METHODS AND COMPOSITIONS USING RNA INTERFERENCE AND ANTISENSE OLIGONUCLEOTIDES FOR INHIBITION OF KRAS

#473
20220073918
2022-03-10

Allele selective inhibition of mutant C9orf72 foci expression by duplex RNAs targeting the expanded hexanucleotide repeat

#474
20220073915
2022-03-10

ARTIFICIAL NUCLEIC ACIDS FOR RNA EDITING

#475
20220073913
2022-03-10

METHODS AND COMPOSITIONS FOR MODULATING ALPHA-1-ANTITRYPSIN EXPRESSION

#476
20220064650
2022-03-03

MODULATION OF HEPATITIS B VIRUS (HBV) EXPRESSION

#477
20220064640
2022-03-03

DOUBLE-STRANDED NUCLEIC ACID INHIBITOR MOLECULES CONTAINING A TRILOOP

#478
20220064636
2022-03-03

MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF

#479
20220056455
2022-02-24

COMPOSITIONS AND METHODS FOR THE TREATMENT OF KCNT1 RELATED DISORDERS

#480
20220056451
2022-02-24

HBV BINDING OLIGONUCLEOTIDES AND METHODS OF USE

#481
20220056448
2022-02-24

Modified double-stranded RNA agents

#482
20220056443
2022-02-24

METABOLIC BENEFITS OF SHORT MIR-22 MIRNA ANTAGOMIR THERAPIES

#483
20220056441
2022-02-24

RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (SINA)

#484
20220056437
2022-02-24

METHODS AND COMPOSITIONS FOR INHIBITION OF CRISPR RE-CLEAVAGE EVENTS

#485
20220049255
2022-02-17

Modulating the cellular stress response

#486
20220049252
2022-02-17

CHEMICALLY-MODIFIED RNAi CONSTRUCTS AND USES THEREOF

#487
20220049248
2022-02-17

MODULATORS OF IRF5 EXPRESSION

#488
20220049240
2022-02-17

Purification methods for guanine-rich oligonucleotides

#489
20220042022
2022-02-10

ANTISENSE OLIGONUCLEOTIDES FOR MODULATING HTRA1 EXPRESSION

#490
20220042013
2022-02-10

Compositions and their uses directed to huntingtin

#491
20220042011
2022-02-10

ANTISENSE OLIGONUCLEOTIDES TARGETING CARD9

#492
20220033819
2022-02-03

Compositions and methods for treatment of cardiac diseases

#493
20220033818
2022-02-03

Oligonucleotides targeting RNA binding protein sites

#494
20220033815
2022-02-03

SYSTEMIC IN VIVO DELIVERY OF OLIGONUCLEOTIDES

#495
20220033814
2022-02-03

METHODS FOR THE TREATMENT OF TRINUCLEOTIDE REPEAT EXPANSION DISORDERS ASSOCIATED WITH MLH1 ACTIVITY

#496
20220033813
2022-02-03

L-OLIGONUCLEOTIDE INHIBITORS OF POLYCOMB REPRESSIVE COMPLEX 2 (PRC2)

#497
20220025376
2022-01-27

Antisense oligomers targeting PCSK9

#498
20220025372
2022-01-27

METHODS FOR TREATMENT OF POLYCYSTIC KIDNEY DISEASE

#499
20220025368
2022-01-27

BISPECIFIC ANTISENSE OLIGONUCLEOTIDES FOR DYSTROPHIN EXON SKIPPING

#500
20220025366
2022-01-27

Compounds and methods for reducing prion expression

#501
20220023429
2022-01-27

CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE

#502
20220017903
2022-01-20

Compositions and methods for treatment of Friedreich's Ataxia

#503
20220010311
2022-01-13

ANGPTL4 oligonucleotides influencing the regulation of the fatty acid metabolism

#504
20220002727
2022-01-06

MODIFIED DOUBLE-STRANDED RNA AGENTS

#505
20220002719
2022-01-06

OLIGONUCLEOTIDE-MEDIATED SENSE CODON REASSIGNMENT

#506
20220002716
2022-01-06

TRINUCLEOTIDE CAP ANALOGS, PREPARATION AND USES THEREOF

#507
20210403916
2021-12-30

Compounds and methods for modulation of dystrophia myotonica-protein kinase (DMPK) expression

#508
20210395753
2021-12-23

ENZYMATIC NUCLEIC ACID MOLECULES

#509
20210395734
2021-12-23

COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION

#510
20210388359
2021-12-16

OLIGONUCLEOTIDE FORMULATION METHOD

#511
20210388357
2021-12-16

Oligonucleotide agonists targeting progranulin

#512
20210380986
2021-12-09

RNA DRUGS AND METHOD OF TREATING AGE-RELATED DISEASE

#513
20210380982
2021-12-09

Antisense oligonucleotide-based progranulin augmentation therapy in neurodegenerative diseases

#514
20210380980
2021-12-09

Methods and Compositions for the ADAR-Mediated Editing of SERPINA1

#515
20210380978
2021-12-09

The long non-coding RNA INCA1 and Homo sapiens heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1) as therapeutic targets for immunotherapy

#516
20210371860
2021-12-02

OLIGONUCLEOTIDES FOR MODULATING MYH7 EXPRESSION

#517
20210369762
2021-12-02

Compositions and methods of treating Facioscapulohumeral muscular dystrophy

#518
20210363222
2021-11-25

Soluble TNF Receptors and Their Use in Treatment of Disease

#519
20210355492
2021-11-18

CARGO LOADED EXTRACELLULAR VESICLES

#520
20210349076
2021-11-11

IN VITRO TOXICITY SCREENING ASSAY

#521
20210346509
2021-11-11

GLP-1 receptor ligand moiety conjugated oligonucleotides and uses thereof

#522
20210346421
2021-11-11

Allele specific modulators of P23H rhodopsin

#523
20210340546
2021-11-04

Methods for reducing LRRK2 expression

#524
20210340540
2021-11-04

CHIMERIC DOUBLE-STRANDED NUCLEIC ACID

#525
20210340534
2021-11-04

Mixed Tricyclo-DNA, 2'-Modified RNA Oligonucleotide Compositions and Uses Thereof

#526
20210317458
2021-10-14

POLYNUCLEOTIDE AGENTS TARGETING PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) AND METHODS OF USE THEREOF

#527
20210317457
2021-10-14

ANTISENSE OLIGONUCLEOTIDE (ASO) MOLECULES AND USES THEREOF FOR CORONAVIRUS DISEASES

#528
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2021-10-07

COMPOUNDS OF CHEMICALLY MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE THEREOF

#529
20210301290
2021-09-30

Compositions and methods of treating Facioscapulohumeral muscular dystrophy

#530
20210292768
2021-09-23

COMPOSITIONS AND AGENTS AGAINST NONALCOHOLIC STEATOHEPATITIS

#531
20210285002
2021-09-16

Oligonucleotides targeting frataxin and related methods

#532
20210277398
2021-09-09

Small cell lung cancer therapeutic agent containing oligonucleotide

#533
20210277392
2021-09-09

CHEMICALLY-MODIFIED GUIDE RNAS TO IMPROVE CRISPR-CAS PROTEIN SPECIFICITY

#534
20210270845
2021-09-02

MICRORNA-134 BIOMARKER

#535
20210269797
2021-09-02

METHODS AND COMPOSITIONS FOR TARGETING PD-L1

#536
20210267893
2021-09-02

Artificial exosome composition and related methods

#537
20210261966
2021-08-26

TREATMENT OF CARDIOMYOPATHY THROUGH MODULATION OF HYPOXIA-INDUCED eRNA ACTIVITY

#538
20210261961
2021-08-26

ANTISENSE OLIGONUCLEOTIDES TARGETING TIA1

#539
20210261945
2021-08-26

Modified compounds and uses thereof

#540
20210254071
2021-08-19

Oligonucleotide comprising an inosine for treating DMD

#541
20210246443
2021-08-12

Antisense oligonucleotides to restore dysferlin protein expression in dysferlinopathy patient cells

#542
20210238608
2021-08-05

Oligonucleotides for modulating SCN9A expression

#543
20210238601
2021-08-05

Oligonucleotide Conjugates

#544
20210238594
2021-08-05

Compositions and methods for improving strand biased

#545
20210238591
2021-08-05

Selective antisense compounds and uses thereof

#546
20210230598
2021-07-29

OLIGONUCLEOTIDES FOR CONTROLLING TAU SPLICING, AND USES THEREOF

#547
20210230589
2021-07-29

Compositions for Modulating C9ORF72 Expression

#548
20210228614
2021-07-29

LACTATE DEHYDROGENASE A (LDHA) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#549
20210222176
2021-07-22

POLYNUCLEOTIDE AGENTS TARGETING FACTOR XII (HAGEMAN FACTOR) (F12) AND METHODS OF USE THEREOF

#550
20210222168
2021-07-22

METHODS FOR REACTIVATING GENES ON THE INACTIVE X CHROMOSOME

#551
20210222166
2021-07-22

LNA BASED NANODEVICE

#552
20210214728
2021-07-15

COMPOSITIONS FOR DELIVERY OF CARGO TO CELLS

#553
20210214725
2021-07-15

COMPOSITIONS FOR MODULATING EXPRESSION OF C9ORF72 ANTISENSE TRANSCRIPT

#554
20210213111
2021-07-15

Compositions and methods for treating pancreatitis

#555
20210207197
2021-07-08

COMPOSITIONS AND METHODS FOR NEXT GENERATION SEQUENCING

#556
20210207146
2021-07-08

Compositions and methods for modulating growth hormone receptor expression

#557
20210189390
2021-06-24

Combination treatment for cystic fibrosis

#558
20210189385
2021-06-24

Closed loop continuous aptamer development system

#559
20210180065
2021-06-17

Antisense oligonucleotides targeting alpha-synuclein and uses thereof

#560
20210180057
2021-06-17

MODULATORS OF ENaC EXPRESSION

#561
20210180054
2021-06-17

Compound for treatment of heart failure

#562
20210179720
2021-06-17

Nucleic acid-polypeptide compositions and uses thereof

#563
20210171967
2021-06-10

bZIP transcription factors regulate conversion of nicotine to nornicotine

#564
20210171948
2021-06-10

COMPOSITIONS AND METHODS FOR TARGETING GLYPICAN-2 IN THE TREATMENT OF CANCER

#565
20210170032
2021-06-10

Antisense nucleic acid targeting PCSK9

#566
20210162011
2021-06-03

Methods for Improving Leptin Sensitivity for the Treatment of Obesity and Diabetes

#567
20210161922
2021-06-03

Antisense-induced exon exclusion in type VII collagen

#568
20210155935
2021-05-27

Modulators of EZH2 expression

#569
20210155930
2021-05-27

MICRORNA TARGETING AGENT FOR TREATMENT OF HEART DISEASE

#570
20210147945
2021-05-20

MiRNAs for treatment and in vitro diagnosis of drug resistant tumors

#571
20210147850
2021-05-20

OLIGONUCLEOTIDES FOR MODULATING RTEL1 EXPRESSION

#572
20210147849
2021-05-20

REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS

#573
20210147847
2021-05-20

Aptamers for targeted activation of T cell-mediated immunity

#574
20210147838
2021-05-20

Selective Antisense Compounds and Uses Thereof

#575
20210147837
2021-05-20

Oligomeric Compounds Comprising Bicyclic Nucleotides and Uses Thereof

#576
20210147535
2021-05-20

Oligonucleotides for reduction of PD-L1 expression

#577
20210139906
2021-05-13

COMPOUNDS AND METHODS FOR REDUCING SPDEF EXPRESSION

#578
20210139899
2021-05-13

Cancer chemoprevention with STAT3 blockers

#579
20210139894
2021-05-13

Treatment of Fuchs' endothelial corneal dystrophy

#580
20210130825
2021-05-06

Ischemic-lesion-site-specific gene therapy

#581
20210130823
2021-05-06

COMPOSITIONS AND METHODS

#582
20210123054
2021-04-29

Oligonucleotides for modulating Tau expression

#583
20210123049
2021-04-29

POLYNUCLEOTIDE AGENTS TARGETING SERPINC1 (AT3) AND METHODS OF USE THEREOF

#584
20210115445
2021-04-22

CHANNEL MODULATORS

#585
20210115438
2021-04-22

Thiophosphoramidites

#586
20210115083
2021-04-22

RNA nanoparticles for brain tumor treatment

#587
20210108205
2021-04-15

MicroRNA Compounds and Methods for Modulating MIR-122

#588
20210108204
2021-04-15

RNA Modulating Oligonucleotides with Improved Characteristics for the Treatment of Duchenne and Becker Muscular Dystrophy

#589
20210102203
2021-04-08

Compositions and methods for modulating MECP2 expression

#590
20210095282
2021-04-01

Modified Oligonucleotides for Treatment of Polycystic Kidney Disease

#591
20210095277
2021-04-01

ANTISENSE OLIGONUCLEOTIDES TARGETING SREBP1

#592
20210095276
2021-04-01

OLIGONUCLEOTIDES FOR MODULATING ERC1 EXPRESSION

#593
20210095275
2021-04-01

OLIGONUCLEOTIDES FOR MODULATING GSK3B EXPRESSION

#594
20210095274
2021-04-01

OLIGONUCLEOTIDES FOR MODULATING PIAS4 EXPRESSION

#595
20210087568
2021-03-25

Modified Guide RNAs for Gene Editing

#596
20210087567
2021-03-25

Therapeutic oligonucleotides

#597
20210087566
2021-03-25

Compositions and methods for modulating apolipoprotein (a) expression

#598
20210087562
2021-03-25

Modulation of alpha synuclein expression

#599
20210087559
2021-03-25

Modulation of frataxin expression

#600
20210079395
2021-03-18

Modulators of APOL1 expression