109186 ⎘
Structure or type of the nucleic acid; Chemical structure; Spatial arrangement of the modifications Gapmers, i.e. of the type ===---===
Compounds and methods for the modulation of COMP
#602SELECTIVE ANTISENSE COMPOUNDS AND USES THEREOF
#603Selective Reactivation of Genes on the Inactive X Chromosome
#604Modulation of AGPAT5 expression
#605Antisense-oligonucleotides as inhibitors of TGF-R signaling
#606Modulation of prekallikrein (PKK) expression
#607Modified TGF-beta oligonucleotide for use in a method of preventing and/or treating an ophthalmic disease
#608Anti-TNF compounds
#609Intergenic RNAS and methods for modulating gene expression and pathogenesis in
#610ANTISENSE COMPOUNDS AND USES THEREOF
#611Antisense design
#612Chimeric single-stranded antisense polynucleotides and double-stranded antisense agent
#613MODULATION OF APOLIPOPROTEIN C-III EXPRESSION
#614MODULATION OF APOLIPOPROTEIN CIII (APOCIII) EXPRESSION
#615Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#616Allele-specific therapy for huntington disease haplotypes
#617Polynucleotide agents targeting Serpinc1 (AT3) and methods of use thereof
#618MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS
#619Treatment of brain derived neurotrophic factor (BDNF) related diseases by inhibition of natural antisense transcript to BDNF
#620Multimetric oligonucleotide compounds
#621Polynucleotide agents targeting aminolevulinic acid synthase-1 (ALAS1) and uses thereof
#622Targeting human satellite II (HSATII)
#623Oligonucleotides for inducing paternal UBE3A expression
#624Compositions and methods for modulating PKK expression
#625Polynucleotide agents targeting complement component C5 and methods of use thereof
#626Antisense compounds
#627Compositions and methods for decreasing tau expression
#628Compositions for modulating Ataxin 2 expression
#629Methods for modulating Ataxin 2 expression
#630ANTISENSE OLIGONUCLEOTIDES AND METHODS OF USE THEREOF
#631Compositions and methods for modulating complement factor B expression
#632COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL ABSORPTION OF CONJUGATED OLIGOMERIC COMPOUNDS
#633Cancer treatment
#634Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
#635Organic compositions to treat APOC3-related diseases
#636Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
#637LINKAGE MODIFIED GAPPED OLIGOMERIC COMPOUNDS AND USES THEREOF
#638Methods and compositions for modulating apolipoprotein (a) expression
#639Compounds and methods for enhanced cellular uptake
#640MODULATORS OF GROWTH HORMONE RECEPTOR
#641Modulation of TMPRSS6 expression
#642Oligomeric compounds comprising alpha-beta-constrained nucleic acid
#643Linkage modified oligomeric compounds
#644Compositions for modulating SOD-1 expression
#645Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#646MODULATION OF FACTOR 11 EXPRESSION
#647RNAi agents modified at the 4′-C position
#648METHOD OF TREATING KELOIDS OR HYPERTROPHIC SCARS USING ANTISENSE COMPOUNDS TARGETING CONNECTIVE TISSUE GROWTH FACTOR (CTGF)
#649Method of Treating Cancer by Inhibition of DNA Repair Proteins
#650Dual targeting antisense oligonucleotides as apoptotic inhibtor therapeutic compostions and methods for their use in the treatment of cancer
#651Inhibition of NEAT1 for treatment of solid tumors
#652Modulation of prekallikrein (PKK) expression
#653Modulation of transthyretin expression
#654Compositions and their uses directed to huntingtin
#655COMPOSITIONS AND METHODS OF USING MICRORNA INHIBITORS
#656Methods and compositions for modulating alpha-1 antitrypsin expression
#657Potent LNA oligonucleotides for the inhibition of HIF-1A expression
#658Antisense design
#659Compounds of chemically modified oligonucleotides and methods of use thereof
#660Modulation of signal transducer and activator of transcription 3 (STAT3) expression
#661MODULATION OF TRANSTHYRETIN EXPRESSION
#662Modulation of huntingtin expression
#663Compositions for modulating C9ORF72 expression
#664Method for reducing circulating leukocytes in a human subject
#665Compositions and methods for inhibiting expression of the ALAS1 gene
#666Compositions and methods for modulating neuronal excitability and motor behavior
#667Formats for organic compounds for use in RNA interference
#668Modulation of apolipoprotein C-III expression
#669METHODS FOR MODULATING EXPRESSION OF C9ORF72 ANTISENSE TRANSCRIPT
#670Tau antisense oligomers and uses thereof
#671Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
#672COMPOSITIONS FOR MODULATING EXPRESSION OF C9ORF72 ANTISENSE TRANSCRIPT
#673Targeting microRNAs for metabolic disorders
#674EPIGENETIC REGULATORS OF FRATAXIN
#675Compounds and methods for modulating target nuclear and sub-nuclear nucleic acid molecules in cells and animals
#676Compounds and methods for modulating target nuclear and sub-nuclear nucleic acid molecules in cells and animals
#677Compositions and methods for modulating angiopoietin-like 3 expression
#678C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders
#679COMPOSITIONS AND METHODS FOR CHARACTERIZING AND TREATING MUSCULAR DYSTROPHY
#680Compounds and methods for modulating apolipoprotein C-III expression for improving a diabetic profile
#681Oligomers with improved off-target profile
#682Compositions for modulating Tau expression
#683Double-stranded agents for delivering therapeutic oligonucleotides
#684Antisense-oligonucleotides as inhibitors of TGF-R signaling
#685Oligonucleotide conjugates
#686ANTISENSE COMPOUNDS AND USES THEREOF
#687Double-stranded antisense nucleic acid with exon-skipping effect
#688OLIGONUCLEOTIDE MODULATORS OF B-CELL CLL/LYMPHOMA 11A (BCL11A) AND USES THEREOF
#689OLIGOMERS TARGETING HEXANUCLEOTIDE REPEAT EXPANSION IN HUMAN C9ORF72 GENE
#690Antisense compounds and uses thereof
#691Compositions and methods for modulating apolipoprotein (a) expression
#692Compositions and methods for modulating apolipoprotein C-III expression
#693Modified TGF-beta oligonucleotides
#694Compositions and methods
#695Phosphorous-linked oligomeric compounds and their use in gene modulation
#696Compositions and methods for modulating HBV expression
#697Modulation of androgen receptor expression
#698Modulation of dystrophia myotonica-protein kinase (DMPK) expression
#699Modified TGF-beta2 oligonucleotides
#700MODULATION OF ANGIOPOIETIN-LIKE 3 EXPRESSION
#701MODULATION OF APOLIPOPROTEIN CIII (APOCIII) EXPRESSION
#702COMPOSITIONS AND THEIR USES DIRECTED TO HUNTINGTIN
#703Modulation of hepatitis B virus (HBV) expression
#704Long interfering nucleic acid duplexes targeting multiple RNA targets
#705Modified TGF-beta oligonucleotide for use in a method of preventing and/or treating an ophthalmic disease
#706Inhibitors of MYH7B and uses thereof
#707Methods for monitoring C9ORF72 expression
#708LNA antisense oligonucleotides for the modulation of Myc expression
#709Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#710Cancer treatment
#711Selective antisense compounds and uses thereof
#712Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
#713Modulation of apolipoprotein C-III (ApoCIII) expression in lipoprotein lipase deficient (LPLD) populations
#714CCCTC-Binding Factor (CTCF) RNA Interactome
#715LNA OLIGONUCLEOTIDE CARBOHYDRATE CONJUGATES
#716Compounds and methods for modulating gene expression
#717Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#718Oligomeric compounds and compositions for the use in modulation of micrornas
#719SNPs OF APOLIPOPROTEIN B AND MODULATION OF THEIR EXPRESSION
#720COMPOUNDS AND METHODS FOR IMPROVED CELLULAR UPTAKE OF ANTISENSE COMPOUNDS
#721Antisense modulation of PTP1B expression
#722Compositions and Methods for Modulation of ATXN3 Expression
#723Methods of delivering multiple targeting oligonucleotides to a cell using cleavable linkers
#724Multimeric oligonucleotides compounds having cleavable linkers
#725Multimeric oligonucleotide compounds having non-nucleotide based cleavable linkers
#726Compositions and methods for modulation of FGFR3 expression
#727Compositions and their uses directed to huntingtin
#728Multimeric oligonucleotides compounds
#729MODULATION OF RENIN-ANGIOTENSIN SYSTEM (RAS) RELATED DISEASES BY ANGIOTENSINOGEN
#730Oligonucleotide conjugates
#731Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome
#732Methods for modulating C9ORF72 expression
#733Oligomeric compounds comprising bicyclic nucleosides and uses thereof
#734Compositions for modulating C9ORF72 expression
#735Modulation of transthyretin expression
#736METHODS FOR SELECTIVE TARGETING OF HETEROCHROMATIN FORMING NON-CODING RNA
#737Selective reactivation of genes on the inactive X chromosome
#738Modulation of UBE3A-ATS expression
#739ANTISENSE MODULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR 4 EXPRESSION
#740Oligomeric compounds comprising bicyclic nucleotides and uses thereof
#741Compositions and methods for modulating HBV expression
#742Modulation of enhancer RNA mediated gene expression
#743Antisense modulation of superoxide dismutase 1, soluble expression
#744Lipid formulations
#745Modulation of huntingtin expression
#746Antisense modulation of GCCR expression
#747Compositions and methods for modulating hemoglobin gene family expression
#748Antisense modulation of GCGR expression
#749Methods and compositions for modulating alpha-1-antitrypsin expression
#750Peptide-conjugated oligonucleotide therapeutic and method of making and using same
#751Targeting MicroRNAs for metabolic disorders
#752Oligomer-conjugate complexes and their use
#753MODULATION OF RNA BY REPEAT TARGETING
#754Methods for modulating metastasis-associated-in-lung-adenocarcinoma-transcript-1 (MALAT-1) expression
#755Modulation of hepatitis B virus (HBV) expression
#756Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#757Modulation of signal transducer and activator of transcription 3 (STAT3) expression
#758Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
#759Selective antisense compounds and uses thereof
#760Methods and compounds useful in conditions related to repeat expansion
#761Stabilized STAT3 decoy oligonucleotides and uses therefore
#762Modulation of TMPRSS6 expression
#763Gapped oligomeric compounds comprising 5′-modified deoxyribonucleosides in the gap and uses thereof
#764Chimeric double-stranded nucleic acid
#765Complement antagonists and uses thereof
#766Antisense design
#767Anti-clusterin monotherapy for cancer treatment
#768Custirsen treatment with reduced toxicity
#769Modulation of transthyretin expression
#770Activation of quiescent stem cells
#771Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
#772Clusterin antisense therapy for treatment of cancer
#773Antisense modulation of PTP1B expression
#774Methods for modulating factor 12 expression
#775Methods for modulating kallikrein (KLKB1) expression
#776Methods for modulating kallikrein (KLKB1) expression
#777Immunostimulatory oligodeoxynucleotides
#778Immunostimulatory oligodeoxynucleotides
#779Modulation of angiopoietin-like 3 expression
#780Immunostimulatory oligodeoxynucleotides
#781Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#782C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders
#783Method of treating cancer by inhibition of DNA repair proteins
#784Oligomeric compounds comprising bicyclic nucleotides and uses thereof
#785Modulation of hepatitis B virus (HBV) expression
#786Modulation of androgen receptor expression
#787TRPM-2 antisense therapy
#788Antisense modulation of fibroblast growth factor receptor 4 expression
#789Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
#790Modulation of alpha synuclein expression
#791Compositions and methods for characterizing and treating muscular dystrophy
#792Methods for modulating factor 12 expression
#793Modulation of apolipoprotein C-III expression
#794Compounds and methods for modulating interaction between proteins and target nucleic acids
#795Compositions and their uses directed to huntingtin
#796Antisense modulation of fibroblast growth factor receptor 4 expression
#797Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
#798Compositions and their uses directed to huntingtin
#799Compounds and methods for modulating expression of DGAT2
#800Antisense modulation of GCCR expression
#801Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
#802Antisense modulation of GCGR expression
#803METHODS AND COMPOSITIONS USEFUL IN TREATMENT OF DISEASES OR CONDITIONS RELATED TO REPEAT EXPANSION
#804MODULATION OF GLUCOSE-6-PHOSPHATASE TRANSLOCASE EXPRESSION
#805Modulation of growth hormone receptor expression and insulin-like growth factor expression
#806Selective reduction of allelic variants
#807miR-150 for the treatment of blood disorders
#808DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#809Modulation of Hepatitis B virus (HBV) expression
#810Modulation of forkhead box O1A expression
#811DOSING REGIMENS FOR TREATING AND PREVENTING OCULAR DISORDERS USING C-RAF ANTISENSE
#812Modulation of angiopoietin-like 3 expression
#813Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
#814TRPM-2 antisense therapy
#815COMPOSITIONS AND THEIR USES DIRECTED TO IL-4R ALPHA
#816MODULATION OF APOLIPOPROTEIN(A) EXPRESSION
#817MODULATION OF HEPATITIS B VIRUS (HBV) EXPRESSION
#818Modulation of glucagon receptor expression
#819Proinflammatory nucleic acids
#820Antisense modulation of PTP1B expression
#821Modulating Gene Expression With agRNA and Gapmers Targeting Antisense Transcripts
#822Stabilized STAT3 decoy oligonucleotides and uses therefor
#823Method of inhibiting miR-33 using a modified oligonucleotide
#824Modulation of eIF4E expression
#825Modulation of signal transducer and activator of transcription 3 (STAT3)expression
#826MODULATION OF TTC39 EXPRESSION TO INCREASE HDL
#827Oligomeric compounds for the modulation of HIF-1A expression
#828Modulation of huntingtin expression
#829Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (CTGF)
#830MODULATION OF DIACYLGLYCEROL ACYLTRANSFERASE 1 EXPRESSION
#831Methods for slowing familial ALS disease progression
#832MODULATION OF FACTOR 7 EXPRESSION
#833COMPOSITIONS AND METHODS FOR THE MODULATION OF JNK PROTEINS
#834COMPOUNDS AND METHODS FOR MODULATING EXPRESSION OF GCGR
#835Antisense oligonucleotide modulation of STAT3 expression
#836RNAi probes targeting cancer-related proteins
#837MODULATION OF SGLT-2 EXPRESSION
#838Lipid formulation
#839Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#840MODULATION OF EIF4E-BP2
#841ANTISENSE OLIGONUCLEOTIDE MODULATION OF RAF GENE EXPRESSION
#842MODULATION OF TRANSTHYRETIN EXPRESSION
#843Targeting MicroRNAs for metabolic disorders
#844Antisense oligomers targeting PCSK9
#845Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#846Modulation of STAT 6 expression
#847COMPOSITIONS AND THEIR USES DIRECTED TO HEPCIDIN
#848MIRNA AND ITS TARGETS RESPECTIVELY THE PROTEINS MADE BASED ON THE TARGETS AS A PROGNOSTIC, DIAGNOSTIC BIOMARKER AND THERAPEUTIC AGENT FOR CANCER
#849ANTISENSE MODULATION OF APOLIPOPROTEIN B EXPRESSION
#850Oligomeric compounds and compositions for the use in modulation of target nucleic acids
#851METHODS OF MODULATING AN IMMUNE RESPONSE TO A VIRAL INFECTION
#852MODULATION OF INFLAMMATORY RESPONSES BY FACTOR XI
#853Antisense modulation of C-reactive protein expression
#854Antisense modulation of PTP1B expression
#855METHODS OF TREATING CANCERS WITH HER3 ANTISENSE OLIGONUCLEOTIDES
#856MicroRNAs In Idiopathic Pulmonary Fibrosis
#857Method for inhibiting the activity of mir-155
#858Antisense modulation of superoxide dismutase 1, soluble expression
#859ANTISENSE MODULATION OF CHOLESTERYL ESTER TRANSFER PROTEIN EXPRESSION
#860LNA ANTAGONISTS TARGETING THE ANDROGEN RECEPTOR
#861SNPs of apolipoprotein B and modulation of their expression
#862Compositions and their uses directed to huntingtin
#863MODULATION OF TRANSTHYRETIN EXPRESSION
#864Modulation of C-reactive protein expression
#865Oligomeric compounds for the modulation of HIF-1α expression
#866RNA ANTAGONISTS TARGETING HSP70-2
#867Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
#868ANTISENSE MODULATION OF STEAROYL-COA DESATURASE EXPRESSION
#869ENHANCED ANTISENSE OLIGONUCLEOTIDES
#870Modulation of HIF1α and HIF2α expression
#871Potent LNA oligonucleotides for the inhibition of HIF-1A expression
#872METHODS FOR MODULATING EXPRESSION OF CREB
#873MODULATION OF TRANSFORMING GROWTH FACTOR-BETA 1 EXPRESSION
#874Conjugates For Use In Hepatocyte Free Uptake Assays
#875Complement antagonists and uses thereof
#876Modulation of glucose-6-phosphatase translocase expression
#877Modulation of CD40 expression
#878Bispecific oligonucleotide for the treatment of CNS malignancies
#879Modulation of SMRT expression
#880Methods for treating androgen receptor dependent disorders including cancers
#881RNA antagonists targeting Hsp27
#882Compositions and their uses directed to acetyl-CoA carboxylases
#883Antiviral Oligonucleotides Having a Conserved G4 Core Sequence
#884RNA ANTAGONISTS TARGETING GLI2
#885Materials and Methods for Treatment of Cancer
#886Methods for modulating expression of RBP4
#887Antisense modulation of C-reactive protein expression
#888Compositions and their uses directed to PTPRU
#889Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
#890Compositions and their uses directed to gemin genes
#891ANTISENSE MODULATION OF BCL2-ASSOCIATED X PROTEIN EXPRESSION
#892Modification of MYD88 splicing using modified oligonucleotides
#893RNA antagonist compounds for the modulation of PIK3CA expression
#894Compounds and methods for modulating expression of SGLT2
#895Modulation of apolipoprotein C-III expression
#896MODULATION OF FACTOR 9 EXPRESSION
#897RNA Antagonist Compounds for the Modulation of FABP4/AP2
#898Method for reducing scarring during wound healing using antisense compounds directed to CTGF
#899Antisense oligonucleotide modulation of STAT3 expression
#900DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION