109191 ⎘
Structure or type of the nucleic acid; Chemical structure; Spatial arrangement of the modifications having a combination of backbone and sugar modifications
Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina)
#1202Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies
#1203Modulation of SOCS-3 expression
#1204Modulation of HIF1alpha and HIF2alpha expression
#1205Modulation of endothelial lipase expression
#1206Antiviral oligonucleotides having a conserved G4 core sequence
#1207RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1208RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1209RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1210RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1211RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1212RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1213Antisense modulation of superoxide dismutase 1, soluble expression
#1214RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1215RNA interference mediated ihibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1216Modulation of apolipoprotein (A) expression
#1217RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1218RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1219RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1220Modulation of apolipoprotein c-III expression
#1221Modulation of STAT 6 expression for the treatment of airway hyperresponsiveness
#1222Combined therapy utilizing reduction of DNA methyltransferase expression and/or activity and interferon
#1223Oligomeric compounds and compositions for use in modulation of pri-mirnas
#1224Potent LNA oligonucleotides for the inhibition of HIF-1A expression
#1225Modulation of HIF-1 beta expression
#1226RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1227RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1228Rna interference mediated treatment of alzheimer's disease using short interfering nucleic acid (sina)
#1229RNA interference mediated inhibition of desmoglein gene expression using short interfering nucleic acid (siNA)
#1230Compositions and their uses directed to thymus and activation-regulated chemokine (TARC)
#1231Modulation of insulin like growth factor I receptor expression
#1232Antisense oligonucleotide modulation of STAT3 expression
#1233RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1234RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1235RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1236RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1237Delivery of polynucleotide agents to the central nervous system
#1238Antisense modulation of farnesoid X receptor expression
#1239Lna-cpg conjugates
#1240Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
#1241RNAi probes targeting cancer-related proteins
#1242Antisense modulation of integrin beta 4 binding protein expression
#1243Oligonucleotide inhibitors of MBD2/DNA demethylase and uses thereof
#1244Modulation of glucocorticoid receptor expression
#1245Antisense modulation of CD40 ligand expression
#1246RNA interference mediated inhibition hairless of (HR) gene expression using short interfering nucleic acid (siNA)
#1247Modulation of SLC26A2 expression
#1248Enzymatic nucleic acid treatment of diseases or conditions related to levels of IKK-gamma and PKR
#1249Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure
#1250Antisense oligonucleotide modulation of raf gene expression
#1251RNA interference mediated inhibition of cyclin dependent kinase-2 (CDK2) gene expression using short interfering nucleic acid (siNA)
#1252RNA interference mediated inhibition of MAP kinase gene expression or expression of genes involved in MAP kinase pathway using short interfering nucleic acid (siNA)
#1253Antisense modulation of vegf co-regulated chemokine-1 expression
#1254Antisense modulation of hydroxysteroid 11-beta dehydrogenase 1 expression
#1255Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure
#1256Antisense oligonucleotides for identifying drug targets and enhancing cancer therapies
#1257Conjugates for use in hepatocyte free uptake assays
#1258Antisense modulation of matrix metalloproteinase 1 expression
#1259Enhanced antisense oligonucleotides
#1260Antisense modulation of hematopoietic cell protein tyrosine kinase expression
#1261Antisense oligonucleotides directed to genes regulated by trapoxin-induced HDAC inhibition
#1262Methods for modulating lipoprotein and cholesterol levels in humans
#1263Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis
#1264Antisense modulation of c/ebp beta expression
#1265Modulation of glucocorticoid receptor expression
#1266Antisense modulation of PTP1B expression
#1267RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
#1268Antisense modulation of C-reactive protein expression
#1269RNA interference mediated inhibtion of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
#1270Effects of apolipoprotein B inhibition on gene expression profiles in animals
#1271Bispecific oligonucleotide for the treatment of CNS malignancies
#1272Modulation of growth hormone receptor expression and insulin-like growth factor expression
#1273Antisense modulation of ptpn12 expression
#1274Modulation of Aurora B expression
#1275Antisense modulation of p70 S6 kinase expression
#1276Modulation of glucose-6-phosphatase translocase expression
#1277Antisense modulation of interleukin 12 P35 subunit expression
#1278RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)
#1279Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#1280RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering RNA
#1281Sequential delivery of oligomeric compounds
#1282Antisense modulation of cellular apoptosis susceptibity gene expression
#1283RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA)
#1284Double stranded constructs comprising one or more short strands hybridized to a longer strand
#1285Modulation of transthyretin expression
#1286Modulation of STAT 6 expression
#1287RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)
#1288RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA)
#1289Modulation of kallikrein 6 expression
#1290Antisense modulation of TFAP2C expression
#1291Antisense modulation of thyroid hormone receptor interactor 6 expression
#1292Polycationic compositions for cellular delivery of polynucleotides
#1293Antisense modulation of mucin 1, transmembrane expression
#1294Hepatocyte free uptake assays
#1295Modulation of tyrosinase expression
#1296Antisense modulation of sterol regulatory element-binding protein-1 expression
#1297RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)
#1298Compositions and their uses directed to signal transducers
#1299Antisense modulation of cellular inhibitor of Apoptosis-2 expression
#1300RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA)
#1301Three component chimeric antisense oligonucleotides
#1302Antisense modulation of dual specific phosphatase 5 expression
#1303Modulation of eIF4E-BP2 expression
#1304RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acis (siNA)
#1305Modulation of SGLT2 expression
#1306RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
#1307RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
#1308Compositions and their uses directed to cell growth and maintenance proteins
#1309Antisense modulation of peroxisome proliferator-activated receptor gamma expression
#1310Antisense modulation of EIF2C1 expression
#1311RNA interference mediated inhibition of NF-Kappa B / REL-A gene expression using short interfering nucleic acid (siNA)
#1312RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering nucleic acid (siNA)
#1313RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
#1314RNA interference mediated inhibition of protein kinase C alpha (PKC-alpha) gene expression using short interfering nucleic acid (siNA)
#1315Modulation of DC-SIGN expression
#1316Modulation of eIF4E-BP1 expression
#1317Antisense modulation of microsomal triglyceride transfer protein expression
#1318RNA interference mediated inhibition of GPRA and AAA1 gene expression using short interfering nucleic acid (siNA)
#1319RNA interference mediated inhibition of cholinergic muscarinic receptor (CHRM3) gene expression using short interfering nucleic acid (siNA)
#1320RNA interference mediated inhibition of protein tyrosine phosphatase type IVA (PRL3) gene expression using short interfering nucleic acid (siNA)
#1321Polymearase III-based expression of therapeutic RNAs
#1322RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA)
#1323RNA interference mediated inhibition of epidermal growth factor receptor (EGFR) gene expression using short interfering nucleic acid (siNA)
#1324Chemically modified double stranded nucleic acid molecules
#1325Compositions and their uses directed to binding proteins
#1326RNA interference mediated inhibition of cholesteryl ester transfer protein (CEPT) gene expression using short interfering nucleic acid (siNA)
#1327RNA interference mediated inhibition of 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA)
#1328RNA interference mediated inhibition of ADAM33 gene expression using short interfering nucleic acid (siNA)
#1329RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA)
#1330RNA interference mediated inhibition of type 1 insulin-like growth factor receptor gene expression using short interfering nucleic acid (siNA)
#1331Modulation of glucocorticoid receptor expression
#1332Methods of using mammalian RNase H and compositions thereof
#1333RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA)
#1334Hepatocyte free uptake assays
#1335Human RNase III and compositions and uses thereof
#1336RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA)
#1337RNA interference mediated inhibition of chromosome translocation gene expression using short interfering nucleic acid (siNA)
#1338RNA interference mediated inhibition of angiopoietin gene expression using short interfering nucleic acid (siNA)
#1339RNA interference mediated inhibition of gastric inhibitory polypeptide (GIP) and gastric inhibitory polypeptide receptor (GIPR) gene expression using short interfering nucleic acid (siNA)
#1340RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)
#1341RNA interference mediated inhibition 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA)
#1342RNA interference mediated inhibition of proliferating cell nuclear antigen (PCNA) gene expression using short interfering nucleic acid (siNA)
#1343Compositions and their uses directed to transferases
#1344Antisense modulation of interferon gamma receptor 2
#1345Methods of using mammalian RNase H and compositions thereof
#1346RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA)
#1347RNA interference mediated inhibition of early growth response gene expression using short interfering nucleic acid (siNA)
#1348RNA interference mediated inhibition of MDR P-glycoprotein gene expression using short interfering nucleic acid (siNA)
#1349Antisense modulation of extracellular-signal-regulated kinase-6 expression
#1350Human RNase H and compositions and uses thereof
#1351Compositions and their uses directed to nucleic acid binding proteins
#1352Antisense oligonucleotides against tenascin for the treating of vitiligo
#1353Antisense modulation of survivin expression
#1354RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
#1355Antisense modulation of phospholipase A2, group IIA (synovial) expression
#1356Microrna as ligands and target molecules
#1357Oligonucleotides comprising alternating segments and uses thereof
#1358Antisense modulation of cholesteryl ester transfer protein expression
#1359RNA interference mediated treatment of Parkinson disease using short interfering nucleic acid (siNA)
#1360RNA interference mediated inhibition of alpha-1 antitrypsin (AAT) gene expression using short interfering nucleic acid (siNA)
#1361RNA interference mediated inhibition of G72 and D-amino acid oxidase (DAAO) gene expression using short interfering nucleic acid (siNA)
#1362RNA interference mediated inhibition of wingless gene expression using short interfering nucleic acid (siNA)
#1363Compositions and their uses directed to signal tranducers
#1364RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA)
#1365RNA interference mediated inhibition of acetyl-CoA-carboxylase gene expression using short interfering nucleic acid (siNA)
#1366RNA interference mediated inhibition of TRPM7 gene expression using short interfering nucleic acid (siNA)
#1367RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA)
#1368Conjugated oligomeric compounds and their use in gene modulation
#1369Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent
#1370RNA interference mediated inhibition of FAS and FASL gene expression using short interfering nucleic acid (siNA)
#1371RNA mediated inhibition connexin gene expression using short interfering nucleic acid (siNA)
#1372Antisense oligonucleotides optimized for kidney targeting
#1373Antisense modulation of inducible nitric oxide synthase expression
#1374Antisense modulation of polo-like kinase expression
#1375Modulation of CEACAM1 expression
#1376RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA)
#1377Antisense modulation of PLML expression
#1378Antisense modulation of caspase 7 expression
#1379Antisense modulation of calreticulin expression
#1380Modulation of phosphodiesterase 4B expression
#1381Compositions and methods for the treatment of severe acute respiratory syndrome (SARS)
#1382Notch1 inhibitors for inducing apoptosis
#1383RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
#1384Antisense modulation of PTP1B expression
#1385Nucleic acid treatment of diseases or conditions related to levels of Ras, HER2 and HIV
#1386RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA)
#1387Modulation of aminopeptidase N expression
#1388RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
#1389Antisense modulation of wrn espression
#1390Antisense oligonucleotide modulation of STAT3 expression
#1391Antisense modulation of ptpn2 expression
#1392RNA interference mediated inhibtion of tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
#1393Antisense modulation of acyl coenzyme a cholesterol acyltransferase-1 expression
#1394Mouse model for bone metabolism
#1395Antisense modulation of connective tissue growth factor expression
#1396CRF2 ligands in combination therapy
#1397Structural motifs and oligomeric compounds and their use in gene modulation
#1398Modified protein kinase a-specific oligonucleotides and methods of their use
#1399RNA interference mediated inhibition hairless (HR) gene expression using short interfering nucleic acid (siNA)
#1400RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
#1401Antisense modulation of insulin-like growth factor binding protein 5 expression
#1402RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
#1403Use of double-stranded ribonucleic acid for inducing cell lysis
#1404Antisense modulation of stearoyl-CoA desaturase expression
#1405Modulation of the RNA interference pathway
#1406RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
#1407Non-phosphorous-linked oligomeric compounds and their use in gene modulation
#1408Antisense modulation of breast cancer-1 expression
#1409RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1410Antisense modulation of superoxide dismutase 1, soluble expression
#1411Modulation of C-reactive protein expression
#1412RNA interference mediated inhibition of muscarinic cholinergic receptor gene expression using short interfering nucleic acid (siNA)
#1413Antisense modulation of hypothetical protein LOC51249 expression
#1414Antisense modulation of apolipoprotein B-expression
#1415Oligonucleotides which inhibit expression of the OB-RGRP protein
#1416Conjugated antisense compounds and their use
#1417Substituted RIG-I agonists: compositions and methods thereof
#1418Compounds and methods for reducing LRRK2 expression
#1419Chimeric oligomeric compounds and their use in gene modulation