109215 ⎘
Structure or type of the nucleic acid; Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
MODULATORY POLYNUCLEOTIDES
#2MODIFIED DOUBLE-STRANDED RNA AGENTS
#3COMPOSITIONS AND METHODS OF NUCLEIC ACID-TARGETING NUCLEIC ACIDS
#4THERAPEUTIC COMPOUNDS AND COMPOSITIONS
#5Ligand-Modified Oligonucleotides
#6COMPOSITIONS AND METHODS OF NUCLEIC ACID-TARGETING NUCLEIC ACIDS
#7CHEMICALLY MODIFIED SINGLE-STRANDED RNA-EDITING OLIGONUCLEOTIDES
#8SIGNAL ACTIVATABLE NUCLEIC ACID CONSTRUCTS WITH WOBBLE BASE PAIRINGS
#9MODIFIED DOUBLE-STRANDED RNA AGENTS
#10COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
#11RNA-Editing Compositions and Methods of Use
#12MODIFIED DOUBLE-STRANDED RNA AGENTS
#13BC200 RNA DECOY COMPOUNDS AND METHODS OF USE FOR THE TREATMENT OF AUTOIMMUNE DISEASES, INCLUDING LUPUS
#14Compositions and Methods for Silencing MYOC Expression
#15Therapeutic Editing
#16Asymmetric Short Duplex DNA as a Novel Gene Silencing Technology and Use Thereof
#17Chemically modified single-stranded rna-editing oligonucleotides
#18COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
#19REDIRECTING RISC FOR RNA EDITING
#20RNA SILENCING AGENTS AND METHODS OF USE
#21GENOME EDITING USING EFFECTOR OLIGONUCLEOTIDES FOR THERAPEUTIC TREATMENT
#22VARIANT RNAi
#23Modified Guide RNAs Comprising an Internal Linker for Gene Editing
#24TARGETED RNA EDITING
#25SYSTEMS, METHODS, AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITING
#26METHODS AND COMPOSITIONS FOR GENERATING A DELETION LIBRARY AND FOR IDENTIFYING A DEFECTIVE INTERFERING PARTICLE (DIP)
#27REDUCING BETA-CATENIN EXPRESSION TO POTENTIATE IMMUNOTHERAPY
#28COMPOSITIONS AND METHODS FOR INHIBITING GYS2 EXPRESSION
#29NUCLEIC ACID CONSTRUCTS FOR DELIVERING POLYNUCLEOTIDES INTO EXOSOMES
#30COMPOSITIONS OF DNA MOLECULES, METHODS OF MAKING THEREFOR, AND METHODS OF USE THEREOF
#31CIRCULAR miRNA SPONGES
#32Compositions and Methods for Modifying Target RNAs
#33Modified double-stranded RNA agents
#34RIG-I Agonists and Methods of Using Same
#35COMPOSITION AND METHODS FOR IMPROVING HEART FUNCTION AND TREATING HEART FAILURE
#36METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF KRAS BY ASYMMETRIC DOUBLE-STRANDED RNA
#37MODIFIED DOUBLE-STRANDED RNA AGENTS
#38Therapeutic editing
#39COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
#40THERAPEUTIC INHIBITION OF LACTATE DEHYDROGENASE AND AGENTS THEREFOR
#41Modified double-stranded RNA agents
#42OLIGONUCLEOTIDE, AND TARGET RNA SITE-SPECIFIC EDITING METHOD
#43SYSTEMS AND METHODS FOR SINGLE-STRAND BREAK SIGNALING AND REPAIR IN A CELL-FREE SYSTEM AND METHODS OF IDENTIFYING MODULATORS OF SINGLE-STRAND BREAK SIGNALING AND REPAIR
#44Extended dicer substrate agents and methods for the specific inhibition of gene expression
#45RNA-Editing Enzyme-Recruiting Oligonucleotides and Uses Thereof
#46COMPOSITIONS AND METHODS FOR RNA INTERFERENCE
#47SYNTHETIC PRODUCTION OF SINGLE-STRANDED ADENO ASSOCIATED VIRAL DNA VECTORS
#48DOUBLE-STRANDED NUCLEIC ACID INHIBITOR MOLECULES WITH SHORTENED SENSE STRANDS
#49Modulatory polynucleotides
#50Extended dicer substrate agents and methods for the specific inhibition of gene expression
#51ARTIFICIAL MICRORNA PRECURSOR AND IMPROVED MICRORNA EXPRESSION VECTOR CONTAINING THE SAME
#52Methods and compositions for editing RNAs
#53ARTIFICIAL NUCLEIC ACIDS FOR RNA EDITING
#54Modified double-stranded RNA agents
#55MODIFIED DOUBLE-STRANDED RNA AGENTS
#56Extended dicer substrate agents and methods for the specific inhibition of gene expression
#57Extended dicer substrate agents and methods for the specific inhibition of gene expression
#58Mixed Tricyclo-DNA, 2'-Modified RNA Oligonucleotide Compositions and Uses Thereof
#59Extended dicer substrate agents and methods for the specific inhibition of gene expression
#60Chemically modified single-stranded RNA-editing oligonucleotides
#61RIG-I Agonists and Methods of Using Same
#62Methods for treating cancers
#63Therapeutic inhibition of lactate dehydrogenase and agents therefor
#64Methods and compositions for the specific inhibition of antithrombin 3 (AT3) by double-stranded RNA
#65COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
#66Compositions and methods for inhibiting GYS2 expression
#67Extended dicer substrate agents and methods for the specific inhibition of gene expression
#68Variant RNAi
#69Methods and compositions for generating a deletion library and for identifying a defective interfering particle (DIP)
#70Modified double-stranded RNA agents
#71Genome editing using effector oligonucleotides for therapeutic treatment
#72Reducing beta-catenin expression to potentiate immunotherapy
#73RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
#74Systems, methods, and compositions for targeted nucleic acid editing
#75ALTERED GUIDE RNAS FOR MODULATING CAS9 ACTIVITY AND METHODS OF USE
#76Therapeutic compositions
#77Targeted RNA editing
#78COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
#79Modulatory polynucleotides
#80Variant RNAi
#81COMPOSITIONS AND METHODS FOR ENHANCING HOMOLOGOUS RECOMBINATION
#82LIGAND-MODIFIED DOUBLE-STRANDED NUCLEIC ACIDS
#83Therapeutic inhibition of lactate dehydrogenase and agents therefor
#84Therapeutic compositions
#85Modified double-stranded RNA agents
#86Modified double-stranded RNA agents
#87Mixed tricyclo-DNA, 2′-modified RNA oligonucleotide compositions and uses thereof
#88Chemically modified single-stranded RNA-editing oligonucleotides
#89COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
#90Modulatory polynucleotides
#91Exosome packaging of nucleic acids
#92Targeted RNA editing
#93Nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction method of RNA interference in eukaryotic host and use of the nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide CAG repeats
#94TARGETING MINIVECTORS TO SPECIFIC TISSUE USING SHAPE
#95Methods and compositions for the specific inhibition of antithrombin 3 (AT3) by double-stranded RNA
#96NUCLEIC ACID MOLECULES WITH ENHANCED ACTIVITY
#97Compositions and Methods of Nucleic Acid-Targeting Nucleic Acids
#98RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
#99Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#100Segmented micro RNA mimetics
#101Double-stranded ribonucleic acid for adjuvants
#102Compositions and methods for inhibiting expression of the ALAS1 gene
#103Variant RNAi
#104Compositions and methods for enhancing homologous recombination
#105RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#106Compositions and methods of nucleic acid-targeting nucleic acids
#107Therapeutic inhibition of lactate dehydrogenase and agents therefor
#108Single-stranded nucleic acid molecule for regulating expression of gene having delivering function
#109DESIGN OF NUCLEIC ACID BINDING MOLECULES WITH NON-WATSON CRICK AND NON-CANONICAL PAIRING BASED ON ARTIFICIAL MUTATION CONSENSUS SEQUENCES TO COUNTER ESCAPE MUTATIONS
#110Therapeutic compositions
#111Chimeric single-stranded antisense polynucleotides and double-stranded antisense agent
#112Modified double-stranded RNA agents
#113METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF MYC BY DOUBLE-STRANDED RNA
#114RNA oligonucleotide and immune system enhancer comprising same
#115Cell-type specific aptamer-siRNA delivery system for HIV-1 therapy
#116Compositions and methods of nucleic acid-targeting nucleic acids
#117Methods and Compositions to Modulate RNA Processing
#118Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#119Nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction method of RNA interferencde in eukaryotic host and use of the nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide CAG repeats
#120Bi-Functional Short-Hairpin RNA (Bi-shRNA) Specific for Single-Nucleotide KRAS Mutations
#121Compositions and methods of nucleic acid-targeting nucleic acids
#122Compositions and methods of nucleic acid-targeting nucleic acids
#123Double-stranded polyC:poly(G/I) RNA for immunostimulation and cancer treatment
#124Nucleic acid inducing RNA interference modified for preventing off-target, and use thereof
#125Mutator Activity Induced by microRNA-155 (miR-155) Links Inflammation and Cancer
#126Compositions and methods of nucleic acid-targeting nucleic acids
#127NUCLEIC ACID MOLECULE FOR INHIBITING ACTIVITY OF RNAI MOLECULE
#128Double-stranded antisense nucleic acid with exon-skipping effect
#129Compositions and methods for inhibiting expression of the ALAS1 gene
#130Compositions and methods of nucleic acid-targeting nucleic acids
#131Therapeutic compositions
#132Genome editing using effector oligonucleotides for therapeutic treatment
#133Segmented micro RNA mimetics
#134Methods and compositions involving miRNA and miRNA inhibitor molecules
#135Methods and compositions involving miRNA and miRNA inhibitor molecules
#136Methods and compositions to modulate RNA processing
#137NICKED OR GAPPED NUCLEIC ACID MOLECULES AND USES THEREOF
#138Double-stranded ribonucleic acid for adjuvants
#139Therapeutics with conformationally restricted monomers
#140METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#141RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#142Methods and compositions for the specific inhibition of MYC by double-stranded RNA
#143Treatment of spinal cord injury or traumatic brain injury by inhibition of synuclein protein aggregation
#144Nucleic acids for down-regulation of gene expression
#145Compositions and methods for inhibiting expression of the ALAS1 gene
#146Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#147Single-stranded nucleic acid molecule for regulating expression of gene having delivering function
#148Extended dicer substrate agents and methods for the specific inhibition of gene expression
#149Extended dicer substrate agents and methods for the specific inhibition of gene expression
#150iRNA Agents Targeting VEGF
#151Methods and compositions involving miRNA and miRNA inhibitor molecules
#152Methods and compositions involving miRNA and miRNA inhibitor molecules
#153Extended dicer substrate agents and methods for the specific inhibition of gene expression
#154METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#155Single-stranded nucleic acid molecule having amino acid backbone
#156Methods and compounds useful in conditions related to repeat expansion
#157Methods and compositions involving miRNA and miRNA inhibitor molecules
#158Therapeutic compositions
#159Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity
#160Methods and compositions for the specific inhibition of MYC by double-stranded RNA
#161RNAI molecules with non-watson crick pairing based on artificial mutation consensus sequences to counter escape mutations
#162Bi-functional short-hairpin RNA (bi-shRNA) specific for single-nucleotide mutations
#163Segmented micro RNA mimetics
#164Selective inhibition of polyglutamine protein expression
#165SiRNA structure for minimizing off-target effects caused by antisense strands, and use thereof
#166Single stranded extended dicer substrate agents and methods for the specific inhibition of gene expression
#167Agent for suppressing expression of dominant allele
#168Mutator activity induced by microRNA-155 () links inflammation and cancer
#169COMPOSITIONS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DSRNA CONTAINING MODIFIED NUCLEOTIDES
#170iRNA Agents Targeting VEGF
#171NUCLEIC ACID COMPOUNDS FOR INHIBITING GENE EXPRESSION AND USES THEREOF
#172Short hairpin RNAs for inhibition of gene expression
#173MULTIPLEX DICER SUBSTRATE RNA INTERFERENCE MOLECULES HAVING JOINING SEQUENCES
#174Duplex oligonucleotides with enhanced functionality in gene regulation
#175Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#176Anti-MicroRNA oligonucleotide molecules
#177Methods and compositions involving miRNA and miRNA inhibitor molecules
#178RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
#179Cell-type specific aptamer-siRNA delivery system for HIV-1 therapy
#180METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#181Compositions and methods for the specific inhibition of gene expression by DSRNA containing a tetraloop
#182RNAI CONSTRUCTS AND USES THEREOF
#183iRNA agents targeting VEGF
#184Cell-type specific aptamer-siRNA delivery system for HIV-1 therapy
#185Therapeutic compositions
#186Anti-MicroRNA oligonucleotide molecules
#187COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION USING ASYMMETRICALLY-ACTIVE PRECURSOR POLYNUCLEOTIDES
#188NUCLEIC ACID COMPOUNDS FOR INHIBITING PLK1 GENE EXPRESSION AND USES THEREOF
#189Therapeutic compositions
#190Single stranded extended dicer substrate agents and methods for the specific inhibition of gene expression
#191Compositions and methods for the specific inhibition of gene expression by dsRNA containing modified nucleotides
#192Anti-microRNA oligonucleotide molecules
#193MULTIPLEX DICER SUBSTRATE RNA INTERFERENCE MOLECULES HAVING JOINING SEQUENCES
#194Therapeutic compositions
#195METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#196Nicked or gapped nucleic acid molecules and uses thereof
#197EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION
#198RESTRICTIVE AGONIST OF TOLL-LIKE RECEPTOR 3 (TLR3)
#199Extended dicer substrate agents and methods for the specific inhibition of gene expression
#200EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION
#201Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity
#202Short hairpin RNAs for inhibition of gene expression
#203NUCLEIC ACID COMPOUNDS FOR INHIBITING GENE EXPRESSION AND USES THEREOF
#204EARLY INTERVENTION OF VIRAL INFECTION WITH IMMUNE ACTIVATORS
#205NUCLEIC ACID COMPOUNDS FOR INHIBITING VEGF FAMILY GENE EXPRESSION AND USES THEREOF
#206Duplex oligonucleotides with enhanced functionality in gene regulation
#207Methods and compositions involving miRNA and miRNA inhibitor molecules
#208Cell-type specific aptamer-siRNA delivery system for HIV-1 Therapy
#209METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#210METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#211METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#212METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#213METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#214Methods and compositions involving miRNA and miRNA inhibitor molecules
#215Methods and compositions involving miRNA and miRNA inhibitor molecules
#216Methods and compositions involving miRNA and miRNA inhibitor molecules
#217Anti-microRNA oligonucleotide molecules
#218Therapeutic compositions
#219Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#220IRNA agents targeting VEGF
#221iRNA agents targeting VEGF
#222Anti-microRNA oligonucleotide molecules
#223Substituted RIG-I agonists: compositions and methods thereof