109234 ⎘
Production chemically synthesised Libraries, arrays
High Throughput Cell-Based Screening For Aptamers
#2METHODS AND COMPOSITIONS FOR DESIGNING AND SELECTING TINYRNAS TO MAXIMIZE TARGET CLEAVAGE
#3APTAMER DISCOVERY AND SELECTION TECHNIQUES
#4SUPPRESSION OF TARGETED APTAMER CLUSTER
#5CREATION AND USE OF GUIDE NUCLEIC ACIDS
#6Oligonucleotides Comprising Modified Nucleosides
#7A METHOD FOR REPRODUCIBLE APTAMER SELECTION USING CLOSED SEQUENCE SOLUTION SPACES
#8GUIDE RNA WITH CHEMICAL MODIFICATIONS
#9NUCLEIC ACID-CONTROLLED CATALYTIC RNAS FOR TRIGGER-RESPONSIVE REGULATION
#10METHOD FOR RNAI FUNGICIDE GENERATING AND THE RNAI FUNGICIDE THEREOF
#11OLIGONUCLEIC ACID VARIANT LIBRARIES AND SYNTHESIS THEREOF
#12FUNCTIONAL LIGANDS
#13CRISPR ENABLED MULTIPLEXED GENOME ENGINEERING
#14METHODS OF GENE ASSEMBLY USING DNAZYMES AND USE IN DNA DATA STORAGE
#15GUIDE RNA WITH CHEMICAL MODIFICATIONS
#16Oligonucleotides comprising modified nucleosides
#17Methods and Compositions for the Single Tube Preparation of Sequencing Libraries Using Cas9
#18OLIGONUCLEOTIDE PROBES AND USES THEREOF
#19METHODS AND COMPOSITIONS FOR ANALYZING NUCLEIC ACID
#20DNA-ENCODED FUNCTIONALIZED APTAMERS
#21BISPECIFIC PERSONALIZED APTAMERS
#22Oligonucleotides and methods for preparing
#23High Throughput Cell-Based Screening for Aptamers
#24APOLIPOPROTEIN B ANTAGONIST
#25METHODS AND COMPOSITIONS FOR REPROGRAMMING CELLS
#26BIOLOGICAL LIBRARIES AND METHODS OF PREPARING AND USING SAME
#27CRISPR enabled multiplexed genome engineering
#28CD44 aptamer
#29METHODS AND COMPOSITIONS FOR MULTIPLEX GENE EDITING
#30METHODS AND COMPOSITIONS FOR ANALYZING NUCLEIC ACID
#31Compositions and Methods Relating to Synthetic RNA Polynucleotides Created From Synthetic DNA Oligonucleotides
#32COMPOSITIONS AND METHODS FOR RNA INTERFERENCE
#33Systems and Methods for Designing RNA Nanostructures and Uses Thereof
#34COMPOSITIONS AND METHODS FOR NUCLEOTIDE MODIFICATION-BASED DEPLETION
#35DIRECT OLIGONUCLEOTIDE SYNTHESIS ON CELLS AND BIOMOLECULES
#36METHOD FOR IDENTIFYING FUNCTIONAL ELEMENTS
#37USE OF BIOLOGICAL RNA SCAFFOLDS WITH IN VITRO SELECTION TO GENERATE ROBUST SMALL MOLECULE BINDING APTAMERS FOR GENETICALLY ENCODABLE BIOSENSORS
#38NOVEL NUCLEIC ACID MODIFIERS
#39CRISPR EFFECTOR SYSTEM BASED MULTIPLEX DIAGNOSTICS
#40Nucleic acid aptamer for influenza virus and detection of influenza virus
#41COMPOSITION COMPRISING A MIXTURE OF DNA MOLECULES, USES THEREOF AS BIOLOGICAL INHIBITOR AND METHOD FOR PRODUCTION
#42CRISPR enabled multiplexed genome engineering
#43Polycomb-associated Non-Coding RNAs
#44Methods and Compositions for the Single Tube Preparation of Sequencing Libraries Using Cas9
#45Method for generating aptamers with improved off-rates
#46COMPOSITIONS AND METHODS FOR HIGHLY EFFICIENT GENETIC SCREENING USING BARCODED GUIDE RNA CONSTRUCTS
#47TARGETED MUTAGENESIS USING BASE EDITORS
#48Functional ligands to opioids and opioid derivatives
#49Methods and Compositions for the Single Tube Preparation of Sequencing Libraries Using Cas9
#50CRISPR enabled multiplexed genome engineering
#51Methods for extending polynucleotides
#52Oligonucleotides comprising modified nucleosides
#53METHOD FOR SCREENING AND IDENTIFYING FUNCTIONAL LNCRNAS
#54Treatment of angiogenesis disorders
#55GUIDE RNA WITH CHEMICAL MODIFICATIONS
#56Fibronectin type III domain proteins with enhanced solubility
#57Oligonucleotide probes and uses thereof
#58Oligonucleic acid variant libraries and synthesis thereof
#59Direct oligonucleotide synthesis on cells and biomolecules
#60CRISPR enabled multiplexed genome engineering
#61Molecular sensor selection
#62STEREODEFINED SUB-MOTIF OPTIMISATION METHODS
#63SYNTHETIC HAMMERHEAD RIBOZYMES WITH LIGAND-RESPONSIVE TERTIARY INTERACTIONS
#64High throughput cell-based screening for aptamers
#65USE OF BIOLOGICAL RNA SCAFFOLDS WITH IN VITRO SELECTION TO GENERATE ROBUST SMALL MOLECULE BINDING APTAMERS FOR GENETICALLY ENCODABLE BIOSENSORS
#66CREATION AND USE OF GUIDE NUCLEIC ACIDS
#67CRISPR enabled multiplexed genome engineering
#68CRISPR enabled multiplexed genome engineering
#69Amplifying oligonucleotides and producing libraries of dual guide constructs
#70Method for blocking miRNA
#71CRISPR enabled multiplexed genome engineering
#72CRISPR enabled multiplexed genome engineering
#73Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
#74Treatment of angiogenesis disorders
#75Simplified method for size-purification of small oligonucleotides via gel electrophoresis
#76HYBRID NUCLEIC ACID MOLECULES AND THEIR USE
#77Efficient genetic screening method
#78Methods and compositions for multiplex RNA guided genome editing and other RNA technologies
#79Method for generating aptamers with improved off-rates
#80Methods and Compositions for Selecting siRNA of Improved Functionality
#81Processes and host cells for genome, pathway, and biomolecular engineering
#82CRISPR enabled multiplexed genome engineering
#83Method for Generating Aptamers with Improved Off-Rates
#84Generic System of Antisense Oligonucleotide
#85Functional ligands to lipoarabinomannan
#86CTLA-4-targeting trans-splicing ribozyme for delivery of chimeric antigen receptor, and use thereof
#87Compositions and methods relating to synthetic RNA polynucleotides created from synthetic DNA oligonucleotides
#88COMPOSITIONS AND METHODS FOR PREPARING SHORT RNA MOLECULES AND OTHER NUCLEIC ACIDS
#89CRISPR enabled multiplexed genome engineering
#90Oligonucleotides comprising modified nucleosides
#91Methods and Compositions for the Single Tube Preparation of Sequencing Libraries Using Cas9
#92Oligonucleotide probes and uses thereof
#93CRISPR enabled multiplexed genome engineering
#94Depletion of Abundant Serum Proteins to Facilitate Biomarker Discovery
#95Methods and compositions for reprogramming cells
#96Methods and compositions for reprogramming cells
#97CRISPR-CAS SGRNA LIBRARY
#98METHODS OF CONTROLLING CELL FATE AND CONSEQUENCES FOR DISEASE
#99Processes and host cells for genome, pathway, and biomolecular engineering
#100De novo synthesized nucleic acid libraries
#101Delivery, use and therapeutic applications of the CRISPR-cas systems and compositions for modeling mutations in leukocytes
#102Method and kit for analyte detection
#103Functional ligands to target molecules
#104CRISPR enabled multiplexed genome engineering
#105CRISPR enabled multiplexed genome engineering
#106Molecular sensor selection
#107Methods and compositions for selecting siRNA of improved functionality
#108Synthetic hammerhead ribozymes with ligand-responsive tertiary interactions
#109Method for generating aptamers with improved off-rates
#110Small-interfering RNA expression systems for production of small-interfering RNAs and their use
#111In vitro selection of formaldehyde cross-linking aptamers
#112Methods and compositions for generating CRISPR guide RNA libraries
#113Method for blocking miRNA
#114COMPOSITIONS AND METHODS FOR PREPARING SHORT RNA MOLECULES AND OTHER NUCLEIC ACIDS
#115Compositions and methods for inhibition of nucleic acids function
#116Guide RNA with chemical modifications
#117FUNCTIONAL LIGANDS TO RICIN
#118Method for improving heterologous synthesis of into polyketides and use of same
#119Treatment of angiogenesis disorders
#120Methods and Compositions for Selecting siRNA of Improved Functionality
#121Chiral library screen
#122Methods for modulating ATRX-dependent gene repression
#123Compositions and methods relating to synthetic RNA polynucleotides created from synthetic DNA oligonucleotides
#124MODULATION OF APOLIPOPROTEIN C-III EXPRESSION
#125CRISPR enabled multiplexed genome engineering
#126Nucleic acid aptamers
#127Pri-mirna libraries and methods for making and using pri-mirna libraries
#128Method for Generating Aptamers with Improved Off-Rates
#129Method of isolating aptamers for minimal residual disease detection
#130Oligonucleic acid variant libraries and synthesis thereof
#131Polycomb-associated non-coding RNAs
#132FUNCTIONAL LIGANDS TO TARGET MOLECULES AND METHODS
#133Tools and Methods for Targeting Oligonucleotide Repeat RNA Toxicity
#134Polycomb-associated non-coding RNAs
#135Compositions and methods for inhibition of nucleic acids function
#136Polycomb-associated non-coding RNAS
#137Polycomb-associated non-coding RNAs
#138Polycomb-associated non-coding RNAs
#139Clonal analysis of functional genomic assays and compositions for practicing same
#140Small interfering RNAs with target-specific seed sequences
#141ANTI-VIRAL THERAPY
#142Nucleotide derivative or salt thereof, nucleotide-derived 5′-phosphate ester or salt thereof, nucleotide-derived 3′-phosphoramidite compound or salt thereof, and polynucleotide
#143Methods and devices for detection and measurement of analytes
#144Guide RNA with chemical modifications
#145Methods and compositions for multiplex RNA guided genome editing and other RNA technologies
#146Functional genomics using CRISPR-Cas systems, compositions, methods, screens and applications thereof
#147Modulation of apolipoprotein C-III expression
#148Methods and compositions for selecting siRNA of improved functionality
#149Methods and compositions for selecting siRNA of improved functionality
#150Processes and host cells for genome, pathway, and biomolecular engineering
#151Method for purifying active GLA-domain coagulation proteins
#152Nucleic acid aptamers
#153Method for evaluating redox activity of nucleic acid molecule and nucleic acid molecule having redox activity
#154Random RNAi libraries, methods of generating same, and screening methods utilizing same
#155Method for screening for high L-tryptophan producing microorganisms using riboswitch
#156Construction of pool of interfering nucleic acids covering entire RNA target sequence and related compositions
#157Treatment of angiogenesis disorders
#158Compositions and methods for inhibition of nucleic acids function
#159High complexity siRNA pools
#160NUCLEOTIDES FOR PREVENTION AND TREATMENT OF BACTERIAL AND FUNGAL PATHOLOGIES
#161DESIGN OF NUCLEIC ACID BINDING MOLECULES WITH NON-WATSON CRICK AND NON-CANONICAL PAIRING BASED ON ARTIFICIAL MUTATION CONSENSUS SEQUENCES TO COUNTER ESCAPE MUTATIONS
#162Screening method
#163Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
#164pRNA multivalent junction domain for use in stable multivalent RNA nanoparticles
#165Method for evaluating redox activity of nucleic acid molecule and nucleic acid molecule having redox activity
#166Methods of X-aptamer generation and compositions thereof
#167Composition containing antisense oligonucleotide to micro RNA
#168Catalytic nucleic acid probes as microbial indicators
#169Small interfering RNAS with target-specific seed sequences
#170Treatment of angiogenesis disorders
#171Functional ligands to target molecules
#172Method for purifying GLA-domain coagulation proteins
#173Method for purifying active GLA-domain coagulation proteins
#174Single molecule nucleic acid nanoparticles
#175SPARC ANTISENSE COMPOSITIONS AND USES THEREOF
#176METHODS AND COMPOSITIONS FOR REDUCING TARGET GENE EXPRESSION USING COCKTAILS OF siRNAS OR CONSTRUCTS EXPRESSING siRNAS
#177METHODS AND KITS TO GENERATE miRNA- AND SMALL RNA-EXPRESSING VECTORS, AND ITS APPLICATION TO DEVELOP LENTIVIRAL EXPRESSION LIBRARIES
#178COMPOSITIONS AND METHODS FOR PREPARING SHORT RNA MOLECULES AND OTHER NUCLEIC ACIDS
#179PRODUCTION PROCESS OF HIGH AFFINITY AND HIGH SPECIFICITY OLIGONUCLEOTIDES FOR ORGANIC AND INORGANIC MOLECULES
#180INHIBITION OF TRIM62 ACTIVITY REDUCES CANCER CELL PROLIFERATION
#181DNA virus MicroRNA and methods for inhibiting same
#182METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR THE DIAGNOSIS AND TREATMENT OF DISEASES INVOLVING INFLAMMATION
#183Compositions and methods for micro-RNA expression profiling of colorectal cancer
#184DIRECT SELECTION OF STRUCTURALLY DEFINED APTAMERS
#185Compositions and methods for inhibition of nucleic acids function
#186Lariat aptamer: aptamer candidate exclusion by nuclease digestion
#187Method for selecting SIRNAs from a plurality of SIRNAs for gene silencing
#188Method for generating aptamers with improved off-rates
#189Methods for identifying and compounds useful for increasing the functional activity and cell surface expression of CF-associated mutant cystic fibrosis transmembrane conductance regulator
#190DNA molecule for expressing Hairpin RNA, the constructing method and the use thereof
#191METHODS AND COMPOSITIONS FOR REDUCING TARGET GENE EXPRESSION USING COCKTAILS OF siRNAS OR CONSTRUCTS EXPRESSING siRNAS
#192DOUBLE-STRANDED NUCLEIC ACID
#193MICRORNA-BASED DIAGNOSTIC TESTING AND THERAPIES FOR INFLAMMATORY BOWEL DISEASE AND RELATED DISEASES
#194TREATMENT OF CANCER
#195Modulation of apolipoprotein C-III expression
#196TUMOR SUPPRESSOR GENE SCREENING USING RNA INTERFERENCE LIBRARIES AND METHOD OF TREATMENT
#197CELL-BASED RNA INTERFERENCE AND RELATED METHODS AND COMPOSITIONS
#198Nucleic acids involved in viral infection
#199Composition And Method For Increasing Efficiency Of Introduction Of Target Substance Into Cell
#200GENES INVOLVED IN MITOCHONDRIAL BIOGENESIS
#201Methods and compositions for regulating cell cycle progression
#202Randomized dna libraries and double-stranded rna libraries, use and method of production thereof
#203Screening method
#204Random RNAi libraries, methods of generating same, and screening methods utilizing same
#205miR-34 Regulated Genes and Pathways as Targets for Therapeutic Intervention
#206Novel HIV Targets
#207COMPOSITIONS AND METHODS FOR PREPARING SHORT RNA MOLECULES AND OTHER NUCLEIC ACIDS
#208Methods and compositions for silencing genes without inducing toxicity
#209Inducible SIRNA expression cassette and method of use
#210NUCLEIC ACIDS HYBRIDIZABLE TO MICRO RNA AND PRECURSORS THEREOF
#211Construction of pool of interfering nucleic acids covering entire RNA target sequence and related compositions
#212Method for generating aptamers with improved off-rates
#213Identification of genetic alterations that modulate drug sensitivity in cancer treatments
#214Method of designing siRNAs for gene silencing
#215Cell-Based Rna Interference and Related Methods and Compositions
#216Methods and compositions for RNA interference
#217Methods and Compositions Relating to Gene Silencing
#218Single-stranded antimicrobial oligonucleotides and uses thereof
#219Cell-based RNA interference and related methods and compositions
#220Methods, libraries and computer program products for determining whether siRNA induced phenotypes are due to off-target effects
#221Method for manufacturing specific binding molecules against selected target molecules, kit, and binding molecules
#222Arrays containing cleavable RNAi molecules
#223Method for preparing short hairpin RNA from CDNA
#224Methods, libraries and computer program products for gene silencing with reduced off-target effects
#225Method of selecting targets for gene silencing by RNA interference
#226Small interfering RNA libraries and methods of synthesis and use
#227Method of producing short hairpin library
#228RNA interference
#229Small regulatory RNAs and methods of use
#230Methods and compositions for silencing genes without inducing toxicity
#231Methods and compositions for RNA interference
#232Nucleotides for prevention and treatment of bacterial and fungal pathologies
#233Combinatorial selection of phosphorothioate aptamers for RNases
#234Modulation of apolipoprotein c-III expression
#235Method for obtaining an enriched population of siRNA-expressing cells
#236Cross reactive arrays of three-way junction sensors for steroid determination
#237Thio-siRNA aptamers
#238Apparatus and system having dry control gene silencing compositions
#239Eukaryotic genes involved in adult lifespan regulation
#240Methods and compositions for RNA interference
#241Method of determining a cellular response to a biological agent
#242Compositions and methods that modulate RNA interference
#243Molecular targeting of the IGF-1 receptor
#244DNA virus microRNA and methods for inhibiting same
#245siRNA knockout assay method and constructs
#246siRNA expression system and method for producing functional gene knock-down cell using the system
#247Virally-encoded RNAs as substrates, inhibitors and delivery vehicles for RNAi
#248Modulation of gene expression using DNA-DNA hybrids
#249RNA interference mediated target discovery and target validation using short interfering nucleic acid (siNA)
#250Methods and compositions for siRNA expression
#251RNA-based transcriptional regulators
#252Double-stranded nucleic acid
#253Compositions and methods for preparing short RNA molecules and other nucleic acids
#254Sirna expression system and process for producing functional gene knockdown cell or the like using the same
#255Methods and compositions for selective RNAi mediated inhibition of gene expression in mammal cells
#256siRNA libraries optimized for predetermined protein families
#257Oligodeoxynucleotide intervention for prevention and treatment of sepsis
#258Cross reactive arrays of three-way junction sensors for steriod determination
#259Methods and compositions for modulating apoptosis