108955 ⎘
Enzymes; Proenzymes; Compositions thereof ; Processes for preparing, activating, inhibiting, separating or purifying enzymes; Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
ALPHA-GALACTOSIDASE PROTEIN FOR ENZYME REPLACEMENT THERAPY (ERT) AND METHODS OF USE
#2HYBRID AAV VECTOR ENHANCING TRANSGENE EXPRESSION IN THE LIVER
#3COMPOUNDS, DEVICES, AND USES THEREOF
#4STABILIZED ALPHA-GALACTOSIDASE AND USES THEREOF
#5Highly Potent Acid Alpha-Glucosidase With Enhanced Carbohydrates
#6ICAM-1 TARGETED FUSION ENZYMES
#7HUMAN ALPHA-GALACTOSIDASE VARIANTS
#8COMPOSITIONS AND METHODS FOR INTERNALIZING ENZYMES
#9NOVEL IN VITRO AND IN VIVO ENRICHMENT STRATEGY TARGETING LYMPHOCYTES DERIVED FROM VECTOR TRANSDUCED HSCS FOR THERAPY OF DISORDERS
#10HUMAN ALPHA-GALACTOSIDASE VARIANTS
#11Lipid Nanoparticle Compositions and Methods for mRNA Delivery
#12Lipid Nanoparticle Compositions and Methods for mRNA Delivery
#13RECOMBINANT AAV FOR THE GENE THERAPY OF FABRY DISEASE
#14Human alpha-galactosidase variants
#15COMPOSITION COMPRISING GALACTINOL AND USE THEREOF
#16Integrated Continuous Manufacturing of Therapeutic Protein Drug Substances
#17METHODS AND COMPOSITIONS FOR INCREASING N-ACETYLGLUCOSAMINIDASE ACTIVITY IN THE CNS
#18ENGINEERED ALPHA-GALACTOSIDASE A (A-GAL A) PEPTIDES AND FUNCTIONAL VARIANTS THEREOF AND ASSOCIATED METHODS OF TREATING FABRY DISEASE
#19DIGITAL MICROBIOLOGY
#20ICAM-1 targeted fusion enzymes
#21Compositions and Methods for Treating Fabry Disease
#22COMPOUNDS, DEVICES, AND USES THEREOF
#23COMPOSITIONS AND METHODS FOR INCREASING EXTRACTIBILITY OF SOLIDS FROM COFFEE BEANS
#24SITE-SPECIFIC GLYCAN REMODELING OF LYSOSOMAL ENZYMES AND APPLICATIONS THEREOF
#25GENETICALLY MODIFIED HUMAN CELL LINES AND USES THEREOF
#26DOUBLE KNOCKOUT (GT/CMAH-KO) PIGS, ORGANS AND TISSUES
#27COMPOSITION AND METHODS FOR THE TREATMENT OF FABRY DISEASE
#28Method and special complex enzyme for hydrolyzing galactomannan (GM) to prepare small-molecule GM and galactomannan oligosaccharide (GMOS)
#29METHOD FOR OBTAINING MATERIAL FROM PLANT CELL SURFACES
#30CODON OPTIMIZED GLA GENES AND USES THEREOF
#31MRNA THERAPY FOR POMPE DISEASE
#32LYSOSOMAL ENZYMES MODIFIED BY CELL BASED GLYCOENGINEERING
#33USE OF THERAPEUTIC ENZYME FUSION PROTEIN IN PREVENTION AND TREATMENT OF NEUROPATHY CAUSED BY OR ACCOMPANIED BY FABRY DISEASE
#34COMPOSITIONS AND METHODS FOR TREATMENT OF FABRY DISEASE
#35AFFINITY PURIFICATION OF GLYCOSIDE-CLEAVING ENZYMES
#36Yeast promotors for protein expression
#37Novel In Vitro and In Vivo Enrichment Strategy Targeting Lymphocytes Derived from Vector Transduced HSCS for Therapy of Disorders
#38Lipid nanoparticle compositions and methods for mRNA delivery
#39POLYNUCLEOTIDES ENCODING ALPHA-GALACTOSIDASE A FOR THE TREATMENT OF FABRY DISEASE
#40FOOD SUPPLEMENT COMPOSITION TO AID IN DIGESTION OF FRUCTAN, MANNITOL, AND SORBITOL
#41LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY
#42Lipid nanoparticle compositions and methods for MRNA delivery
#43Lipid nanoparticle compositions and methods for MRNA delivery
#44Highly Potent Acid Alpha-Glucosidase With Enhanced Carbohydrates
#45Codon optimized GLA genes and uses thereof
#46ANIMAL FEED COMPOSITIONS
#47Recombinant Alpha-Galactosidase A For Treatment Of Fabry Disease
#48STABILIZED ALPHA-GALACTOSIDASE AND USES THEREOF
#49Glycosylated lysosomal proteins, method of production and uses
#50Lipid nanoparticle compositions and methods for mRNA delivery
#51LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY
#52Human alpha-galactosidase variants
#53Improved Alpha-Galactosidase Protein for Enzyme Replacement Therapy (ERT) and Methods of Use
#54A GENETICALLY MODIFIED FUNGUS AND METHODS AND USES RELATED THERETO
#55METHODS AND COMPOSITIONS FOR THE TREATMENT OF FABRY DISEASE
#56ICAM-1 targeted fusion enzymes
#57Digital microbiology
#58Highly potent acid alpha-glucosidase with enhanced carbohydrates
#59Modified recombinant lysosomal alpha-galactosidase A and aspartylglucoaminidase having low mannose-6-phosphate and high sialic acid
#60NOVEL ALPHA-GALACTOSIDASE A DERIVATIVES
#61Lipid nanoparticle compositions and methods for mRNA delivery
#62LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY
#63Lipid nanoparticle compositions and methods for MRNA delivery
#64Lipid nanoparticle compositions and methods for mRNA delivery
#65RECOMBINANT ADENO-ASSOCIATED VIRAL VECTOR FOR GENE DELIVERY
#66Recombinant Glycoproteins and Uses Thereof
#67mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES
#68Lipid nanoparticle compositions and methods for mRNA delivery
#69FABRY DISEASE GENE THERAPY
#70MRNA therapy for pompe disease
#71Codon optimized GLA genes and uses thereof
#72Lipid nanoparticle compositions and methods for mRNA delivery
#73Polypeptides having alpha-galactosidase activity and polynucleotides encoding same
#74Microorganism capable of displaying α-galactosidase on surface layer thereof, and use thereof
#75HUMAN ALPHA-GALACTOSIDASE VARIANTS
#76Highly potent acid alpha-glucosidase with enhanced carbohydrates
#77Human alpha-galactosidase variants
#78COMPOSITIONS AND METHODS FOR INCREASING EXTRACTABILITY OF SOLIDS FROM COFFEE BEANS
#79ICAM-1 targeted fusion enzymes
#80Double knockout (GT/CMAH-KO) pigs, organs and tissues
#81Lipid nanoparticle compositions and methods for mRNA delivery
#82Affinity purification of glycosidase-cleaving enzymes
#83Yeast promotors for protein expression
#84ANIMAL CELL STRAIN AND METHOD FOR USE IN PRODUCING GLYCOPROTEIN, GLYCOPROTEIN AND USE THEREOF
#85THERAPEUTIC ENZYME FUSION PROTEIN HAVING A NOVEL STRUCTURE AND USE THEREOF
#86Human alpha-galactosidase variants
#87Polypeptides Having Alpha-Galactosidase Activity and Polynucleotides Encoding Same
#88Polypeptides Having Alpha-Galactosidase Activity and Polynucleotides Encoding Same
#89Sterile chromatography and manufacturing processes
#90Human alpha-galactosidase variants
#91Human alpha-galactosidase variants
#92Lipid nanoparticle compositions and methods for mRNA delivery
#93Integrated continuous manufacturing of therapeutic protein drug substances
#94METHODS AND COMPOSITIONS FOR THE TREATMENT OF FABRY DISEASE
#95Human alpha-galactosidase variants
#96and enrichment strategy targeting lymphocytes derived from vector transduced HSCs for therapy of disorders
#97Polynucleotides encoding α-galactosidase A for the treatment of Fabry disease
#98Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
#99Immunogenic compositions for the prevention and treatment of meningococcal disease
#100Elution of biomolecules from multi-modal resins using MES and MOPS as mobile phase modifiers
#101PHARMACEUTICAL COMBINATION FOR TREATMENT OF FABRY DISEASE AND USE THEREOF
#102LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR MRNA DELIVERY
#103Compounds, devices, and uses thereof
#104Recombinant α-galactosidase A for treatment of Fabry disease
#105Lipid nanoparticle compositions and methods for mRNA delivery
#106Animal feed additives
#107Highly potent acid alpha-glucosidase with enhanced carbohydrates
#108Stabilized alpha-galactosidase and uses thereof
#109Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from and related organisms, methods
#110Lipid nanoparticle compositions and methods for mRNA delivery
#111Lipid nanoparticle compositions and methods for mRNA delivery
#112IMMUNOGENIC COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF MENINGOCOCCAL DISEASE
#113Polypeptides having alpha-galactosidase activity and polynucleotides encoding same
#114MRNA therapy for Pompe disease
#115Glycosylation independent proteins
#116Scavenger receptor uptake for Fabry disease enzyme replacement therapy
#117Polynucleotide Constructs For In Vitro and In Vivo Expression
#118Targeting of glycoprotein therapeutics
#119Conjugate of therapeutic enzymes
#120Digital microbiology
#121Polynucleotides encoding alpha-galactosidase A for the treatment of Fabry disease
#122Polynucleotides encoding α-galactosidase A for the treatment of Fabry disease
#123Methods of purifying recombinant alpha-Galactosidase A
#124STERILE CHROMATOGRAPHY AND MANUFACTURING PROCESSES
#125Porcine animals lacking expression of functional alpha 1, 3 galactosyltransferase
#126RECOMBINANT MICROALGAE INCLUDING KETO-ACYL ACP SYNTHASE
#127MRNA for use in treatment of human genetic diseases
#128Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from and related organisms, methods
#129Chemical crosslinkers
#130THERAPEUTIC COMPOSITIONS OF ALPHA-L-IDURONIDASE, IDURONATE-2-SULFATASE, AND ALPHA-GALACTOSIDASE A AND METHODS OF USE THEREOF
#131Double knockout (GT/CMAH-KO) pigs, organs and tissues
#132Stabilized α-galactosidase and uses thereof
#133Methods and compositions for the treatment of Fabry disease
#134Fabry disease gene therapy
#135Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins and applications thereof
#136Glycosylated lysosomal proteins, method of production and uses
#137Method for production of recombinant human alpha-galactosidase A from material containing contaminant host cell proteins by chromatography
#138α-galactosidase A and 1-deoxygalactonojirimycin co-formulation
#139HUMAN ALPHA-GALACTOSIDASE VARIANTS
#140Highly potent acid alpha-glucosidase with enhanced carbohydrates
#141Lipid nanoparticle compositions and methods for MRNA delivery
#142Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose
#143Integrated continuous manufacturing of therapeutic protein drug substances
#144Immunogenic compositions for the prevention and treatment of meningococcal disease
#145NOVEL ALPHA-GALACTOSIDASE A DERIVATIVES
#146TARGETING OF GLYCOPROTEIN THERAPEUTICS
#147MRNA therapy for pompe disease
#148Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from and related organisms, methods
#149Agarooligosaccharide hydrolase and method for producing 3,6-anhydro-L-galactose and galactose from agarose by using same
#150Recombinant glycoproteins and uses thereof
#151Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
#152Tailored oils produced from recombinant heterotrophic microorganisms
#153Polypeptides having a-L-Galactosidase Activity and Polynucleotides Encoding Same
#154Chemical crosslinkers
#155mRNA for use in treatment of human genetic diseases
#156Stabilized alpha-galactosidase and uses thereof
#157Purification of recombinant alpha galactosidase A
#158Recombinant microalgae including keto-acyl ACP synthase
#159Yeast promoters for protein expression
#160Immunogenic compositions for the prevention and treatment of meningococcal disease
#161Thermophilic and thermoacidophilic biopolymer degrading genes and enzymes from and related organisms, methods
#162ELUTION OF BIOMOLECULES FROM MULTI-MODAL RESINS USING MES AND MOPS AS MOBILE PHASE MODIFIERS
#163Double knockout (GT/CMAH-KO) pigs, organs and tissues
#164Expression of enzymes in yeast for lignocellulose derived oligomer CBP
#165Immunogenic compositions for the prevention and treatment of meningococcal disease
#166Method for production of recombinant human alpha-galactosidase A
#167STERILE CHROMATOGRAPHY AND MANUFACTURING PROCESSES
#168Sterile chromatography and manufacturing processes
#169Methods for introducing mannose 6 phosphate and other oligosaccharides onto glycoproteins and applications thereof
#170Integrated continuous manufacturing of therapeutic protein drug substances
#171α-galactosidase A and 1-deoxygalactonojirimycin co-formulation
#172Means and methods for generating improved proteins
#173mRNA for use in treatment of human genetic diseases
#174Glycosidase enzymes
#175Pulmonary delivery of mRNA
#176MRNA therapy for Fabry disease
#177Plant cell culture expressing human lysosomal proteins and uses thereof
#178Integrated continuous manufacturing of therapeutic protein drug substances
#179Enzymatic Conversion of Blood Group A, B, and AB Red Blood Cells Using alpha-N-Acetylgalactosaminidases and alpha-Galactosidases with Unique Substrate Specificities and Kinetic Properties
#180Method of enhancing lysosomal α-galactosidase A
#181Highly functional enzyme having alpha-galactosidase activity
#182Perfusion Culturing Methods and Uses Thereof
#183Method for increasing the activity of lysosomal enzymes
#184Scavenger receptor uptake for fabry disease enzyme replacement therapy
#185Polynucleotides encoding proteins having acquired α-galactosidase activity
#186Methods and compositions for degrading pectin
#187Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from and related organisms, methods
#188Nucleic acid construct for expression of alpha-galactosidase in plants and plant cells
#189Microorganisms genetically engineered to have modified N-glycosylation activity
#190Microorganisms genetically engineered to have modified N-glycosylation activity
#191Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins and applications thereof
#192Highly functional enzyme having α-galactosidase activity
#193Compositions Comprising Tailored Oils
#194Recombinant protein production in heterologous systems
#195Stabilized alpha-galactosidase and uses thereof
#196Tailored oils produced from recombinant heterotrophic microorganisms
#197Novel Immunogenic Compositions For The Prevention And Treatment of Meningococcal Disease
#198Immunogenic compositions for the prevention and treatment of meningococcal disease
#199Immunogenic compositions for the prevention and treatment of meningococcal disease
#200Human lysosomal proteins from plant cell culture
#201Glycosidase enzymes
#202Porcine Animals Lacking Any Expression of Functional Alpha 1,3 Galactosyltransferase
#203OPTIMIZED MESSENGER RNA
#204comprising an α-galactosidase for removing immunodominant α-galactose monosaccharides from blood group B or AB reactive cells
#205Immunogenic compositions for the prevention and treatment of meningococcal disease
#206mRNA for use in treatment of human genetic diseases
#207Targeting of glycoprotein therapeutics
#208Glycosidase Enzymes
#209Enzymatic antibody processing
#210METHODS AND COMPOSITIONS FOR DEGRADING PECTIN
#211NOVEL IMMUNOGENIC COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF MENINGOCOCCAL DISEASE
#212Tailored oils produced from recombinant heterotrophic microorganisms
#213FOOD COMPOSITIONS COMPRISING TAILORED OILS
#214TREATMENT OF ALPHA-GALACTOSIDASE A DEFICIENCY
#215Human lysosomal proteins from plant cell culture
#216Microorganisms genetically engineered to have modified N-glycosylation activity
#217Glycosylation of molecules
#218Human lysosomal proteins from plant cell culture
#219Highly functional enzyme having α-galactosidase activity
#220Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods
#221Method for increasing the activity of lysosomal enzymes
#222Immunogenic compositions for the prevention and treatment of meningococcal disease
#223ENGINEERED MICROORGANISMS AND METHODS OF USE
#224α-galactosidases for removing immunodominant α-galactose monosaccharides from blood group B or AB reactive cells
#225Intraperitoneal Delivery of Genetically Engineered Mesenchymal Stem Cells
#226Intraperitoneal Delivery of Genetically Engineered Mesenchymal Stem Cells
#227Methods of preparing tissues for xenotransplantation using α-galactosidases
#228Glycosidase enzymes
#229Proteins having acquired A-galactosidase activity
#230Intraperitoneal Delivery of Genetically Engineered Mesenchymal Stem Cells
#231Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
#232Highly functional enzyme having α-galactosidase activity
#233Method of enhancing lysosomal α-galactosidase A
#234Cleaning Compositions Comprising Alpha-Galactosidase
#235Methods of treating lysosomal storage related diseases by gene therapy
#236OPTIMIZED MESSENGER RNA
#237Compositions and methods for treating lysosomal storage disease
#238Intraperitoneal Delivery Of Genetically Engineered Mesenchymal Stem Cells
#239Intraperitoneal Delivery Of Genetically Engineered Mesenchymal Stem Cells
#240Method of preparing non-human tissues for xenotransplantation using α-galactosidase
#241Production of high mannose proteins in plant culture and therapeutic uses thereof
#242OPTIMIZED MESSENGER RNA
#243Glycosidase enzymes
#244and HAC1 nucleic acids
#245OPTIMIZED MESSENGER RNA
#246OPTIMIZED MESSENGER RNA
#247ENZYMES HAVING GLYCOSIDASE ACTIVITY AND METHODS OF USE THEREOF
#248Targeting of glycoprotein therapeutics
#249α-agarase and process for producing the same
#250OPTIMIZED MESSENGER RNA
#251Human lysosomal proteins from plant cell culture
#252Genetic modification of the lung as a portal for gene delivery
#253α-agarase and process for producing the same
#254Sulfated fucogalactan digesting enzyme gene
#255Pectate lyases
#256Plant-derived alkaline alpha-galactosidase
#257Method for increasing the activity of acid-β-galactosidase
#258Immunogenic compositions for the prevention and treatment of meningococcal disease
#259α-Agarase and process for producing the same
#260Targeting of glycoprotein therapeutics
#261Method for enhancing mutant protein activity
#262Plant-derived alkaline alpha-galactosidase
#263Methods of reducing an immune response
#264Methods of treating lysosomal storage related diseases by gene therapy
#265In- seed expression of lysosomal enzymes
#266Enzymes having alpha-galactosidase activity and methods of use thereof
#267Blood cells having modified antigenicity
#268Polynucleotide sequences encoding alkaline α-galactosidases and methods of using same
#269Sulfated fucogalactan digesting enzyme gene
#270Cellular membrane protein assay
#271Production of lysosomal enzymes in plants by transient expression
#272Method for enhancing mutant enzyme activities in Gaucher disease
#273Method for recovering proteins from the interstitial fluid of plant tissues
#274Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
#275Methods for sterilizing preparations of glycosidases
#276Recombinant microorganisms for conversion of oligosaccharides into functional sweeteners