112450 ⎘
Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Sub-classes:ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
#2METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS
#3METHOD FOR PREPARING GLYCINE, ACETYL COENZYME A, AND ACETYL COENZYME A DERIVATIVE BY USING THREONINE
#4BIOCATALYSTS AND METHODS FOR HYDROXYLATION OF CHEMICAL COMPOUNDS
#5POLAR MARINE-DERIVED MACROCYCLIC LACTAM COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
#6SCALABLE BIOSYNTHESIS OF THE SEAWEED NEUROCHEMICAL KAINIC ACID
#7Biological degradation of low-rank coals
#8Engineered biocatalysts and methods for synthesizing chiral amines
#9ENDOPHYTIC BACTERIAL STRAIN WITH HIGH CAMPTOTHECIN YIELD AND USE THEREOF
#10ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
#11ATROROSINS AS FOOD COLORS
#12Biocatalysts and methods for hydroxylation of chemical compounds
#13Noscapinoid-producing Microbes and Methods of Making and Using the Same
#14INDOLE DITERPENE BIOSYNTHESIS
#15NOVEL PROLYLFK506 DERIVATIVES HAVING NEURITE GROWTH AND SYNAPSE FORMATION ACTIVITIES AND USES THEREOF
#16METHOD FOR ENZYMATICALLY PRODUCING MAYTANSINOL
#17Materials and methods for producing alkaloids
#18Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
#19TROPANE ALKALOID (TA) PRODUCING NON-PLANT HOST CELLS, AND METHODS OF MAKING AND USING THE SAME
#20METHODS OF IMPROVING PRODUCTION OF MORPHINAN ALKALOIDS AND DERIVATIVES
#21Monooxygenase mutant and use thereof
#22METHOD FOR PRODUCING COMPOUND WITH MODIFIED MOTHER NUCLEUS
#23BIOLOGICAL DEGRADATION OF LOW-RANK COALS
#24sp. SNC087 strain isolated from seawater, method for producing staurosporine using same, method of culturing same, and pure culture medium of same
#25Engineered biocatalysts and methods for synthesizing chiral amines
#26Biocatalysts and methods for hydroxylation of chemical compounds
#274,5-annulated 1,2,4-triazolones
#28Materials and Methods for Producing Alkaloids
#29SALT FORMULATIONS FOR THE FERMENTATION OF MARINE MICROORGANISMS
#30Plant cytochrome P450
#31Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
#32Modular DNA assembly system
#33Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
#34Engineered proline hydroxylase polypeptides and methods
#35Methods for selecting microbes from a diverse genetically modified library to detect and optimize the production of metabolites
#36Process for producing an azaphilone in
#37Engineered biocatalysts and methods for synthesizing chiral amines
#38Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
#394,5-annulated 1,2,4-triazolones
#40Engineered proline hydroxylase polynucleotides and methods
#41Salinosporamides and methods of use thereof
#42COMPOSITIONS AND METHODS FOR THE PRODUCTION OF COMPOUNDS
#43ISOLATION OF CYCLOPAMINE
#44Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
#45Plant cytochrome P450
#46Compositions and Methods For Making Alkaloid Morphinans
#47Nucleic acids encoding engineered imine reductases
#48Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
#49Salt formulations for the fermentation of marine microorganisms
#50Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
#51Engineered biocatalysts and methods for synthesizing chiral amines
#52Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
#53PLANT CYTOCHROME P450
#54Salinosporamides and methods of use thereof
#55Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
#56Compositions and methods for making alkaloid morphinans
#57NOSCAPINOID-PRODUCING MICROBES AND METHODS OF MAKING AND USING THE SAME
#58Papaver somniferum cytochrome P450
#59Methods for hydroxylyation of chemical compounds
#60Methods for increasing molecular diversity of polyketides and non-ribosomal proteins
#61Polynucleotides encoding engineered imine reductases
#62Engineered biocatalysts and methods for synthesizing chiral amines
#63Condensed 5-oxazolidinone derivative
#64Biosynthesis of opiate alkaloids
#65Rapamycin analogues and their pharmaceutical use
#66Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
#67Isolation of Cyclopamine
#68Chromobacterium bioactive compositions and metabolites
#69Plant cytochrome P450
#70Engineered biocatalysts and methods for synthesizing chiral amines
#71Salinosporamides and methods of use thereof
#72Production of polyketides and other natural products
#73Salt formulations for the fermentation of marine microorganisms
#74Engineered proline hydroxylase polypeptides
#75Fermentation process for the production of rapamycin
#76Biosynthetic pathway for heterologous expression of a nonribosomal peptide synthetase drug and analogs
#77Biosynthesis of opiate alkaloids
#78Didemnin biosynthetic gene cluster in
#79Chromobacterium bioactive compositions and metabolites
#80Salinosporamides and methods of use thereof
#81Method to increase the yield of products in plant material
#82Macrocyclic compounds with a hybrid peptidic/non-peptidic backbone and methods for their preparation
#83Engineered imine reductases and methods for the reductive animation of ketone and amine compounds
#84Tacrolimus analogues, a neuroprotective composition comprising the same, an immunosuppressive composition comprising the same, a method for preparing the same, and a mutant for producing the same
#85Methyltransferase nucleic acids and polypeptides
#86Biosynthetic pathway for heterologous expression of a nonribosomal peptide synthetase drug and analogs
#87Production of alkaloids by liliaceae cell culture
#88Process for preparation of tacrolimus
#89Substantially Stereomerically Pure Fused Bicyclic Proline Compounds and Processes for Preparing Boceprevir
#90Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds
#91Salinosporamides and methods for use thereof
#92Anti-inflammatory compounds
#93Stereomerically pure fused bicyclic proline compounds useful for preparing hepatitis C protease inhibitors
#94Aryl (ethanoic) propanoic acid ascorbyl ester, preparation method thereof and medicament containing the same
#95Photochromic polyesters and methods of producing photochromic polyesters
#96bioactive compositions and metabolites
#97Biochemical humic acid product prepared from kitchen waste and the method of preparing the same
#98Gene cluster
#99METHOD OF EXTRACTION AND YIELD-UP OF TRICYCLO COMPOUNDS BY ADDING A SOLID ADSORBENT RESIN AS THEIR CARRIER IN FERMENTATION MEDIUM
#100Production of polyketides and other natural products
#101Glycosylated indolocarbazoles, method for obtaining same and uses thereof
#102Sustainable method for synthesizing tetrodotoxin (TTX)
#103PROLIFERATION PROMOTING AGENT FOR NEURAL STEM CELLS
#104SUBSTITUTED HETEROCYCLES
#105CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF
#106Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof
#107Process for purifying lipopeptides
#108Process for the production of macrolides using a novel strain, sp. BICC 7522
#109Salinosporamides and methods for use thereof
#110Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
#111PROCESS FOR THE PRODUCTION OF CLAVULANIC ACID
#112BIOSYNTHETIC GENE CLUSTER FOR THE PRODUCTION OF A COMPLEX POLYKETIDE
#113Process for Producing Anticancer Agent LL-D45042
#114Isolation of Cyclopamine
#115PHENOXAZINE DYES
#116Salinosporamides and methods for use thereof
#117PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF NEPHRITIS AND MANUFACTURING METHOD THEREOF
#118NOVEL ANSAMITOCIN DERIVATIVES
#119FERMENTATION BROTH EXTRACTION OF K-252A
#120PRODUCTION OF COMPOUNDS IN A RECOMBINANT HOST
#121Cyclic hexadepsipeptides, processes for their production and their use as pharmaceuticals
#122MARINE ACTINOMYCETE TAXON FOR DRUG AND FERMENTATION PRODUCT DISCOVERY
#123Polynucleotides encoding the fkbB gene of the FK-520 polyketide synthase gene cluster
#124Means and Methods to Enhance the Production of Vinblastine and Vincristine in Catharanthus Roseus
#125Biosynthetic gene cluster for the production of a complex polyketide
#126Marine actinomycete taxon for drug and fermentation product discovery
#127Salutaridinol 7--acetyltransferase and derivatives thereof
#128Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
#129Fermentation Processes for the Preparation of Tacrolimus
#130Process for Isolation of Crystalline Tacrolimus
#131Production of Polyketides and Other Natural Products
#132Process for the production of macrolides using a novel strain, sp. BICC 7522
#133Process for Isolation of Macrolide Compounds
#134Salt formulations for the fermentation of marine microorganisms
#135Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof
#136Marine actinomycete taxon for drug and fermentation product discovery
#137Production of polyketides and other natural products
#138Production of polyketides and other natural products
#139Labeling of rapamycin using rapamycin-specific methylases
#140Isolated DNA comprising one or more genes specific for 5S clavam biosynthesis, vectors comprising such DNA and hosts capable of improved clavulanic acid production
#141Production of tacrolimus (fk-506) using new streptomyces species
#142Substrates for beta-lactamase and uses thereof
#143Production of clavulanic acid by genetic engineering of
#144Salinosporamides and methods for use thereof
#145Process for producing tacrolimus (FK-506) using vegetable oil as sole source of carbon
#146Isolation of ansamitocins
#147Fermentative production of lipids on an industrial scale using chemically defined media
#148Fermentation broth extraction of K-252a
#149Substituted heterocycles
#150Recovery of CCI-779 from mother liquors
#151Genes encoding the synthetic pathway for the production of disorazole
#152Process for the recovery of staurosporine from a fermentation broth
#153Biological production of clavulanic acid and related compounds
#154Stereoselective process for the production of dioxolane nucleoside analogues
#155Endophytic camptothecin and camptothecinoid producing fungi and process of producing the same
#156Process for producing anticancer agent LL-D45042
#157Biosynthetic gene cluster for the maytansinoid antitumor agent ansamitocin
#158Production of polyketides and other natural products
#159Marine actinomycete taxon for drug and fermentation product discovery
#160Biosynthetic gene cluster for the production of a complex polyketide
#161Production of polyketides and other natural products
#162Methods for the isolation and purification of ansamitocins
#163Manzamine-producing actinomycetes
#164Salinosporamides and methods for use thereof
#165Labeling of rapamycin using rapamycin-specific methylases
#166Regiospecific synthesis of rapamycin 42-ester derivatives
#167Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
#168Methods for the production of ansamitocins
#169Butyrylcholinesterase variants that alter the activity of chemotherapeutic agents
#170Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
#171Compositions and methods for treating glaucoma and ocular hypertension
#172Osteoclast differentiation inhibitors
#173Polynucleotides encoding disorazole polyketide synthase polypeptides
#174Mutant strain with increased maytansinoid production
#175Process for obtaining a naphthoquinone derivative from sp
#176Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
#177Method to increase the yield of products in plant material
#178Synthesis of non-natural cofactor analogs of S-adenosyl-L-methionine using methionine adenosyltransferase