ClassID:

113847

C12Y105/01003 - CPC Classification

Classification description:

Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1) Dihydrofolate reductase (1.5.1.3)

Recent Application in this class:
#1
20260152731
2026-06-04

CRISPR HAVING OR ASSOCIATED WITH DESTABILIZATION DOMAINS

#2
20260125701
2026-05-07

COMPOSITIONS AND METHODS FOR CHIMERIC LIGAND RECEPTOR (CLR)-MEDIATED CONDITIONAL GENE EXPRESSION

#3
20260125700
2026-05-07

COMPOSITIONS AND METHODS FOR CHIMERIC LIGAND RECEPTOR (CLR)-MEDIATED CONDITIONAL GENE EXPRESSION

#4
20250388931
2025-12-25

REGULATION OF GENE EXPRESSION BY APTAMER-MEDIATED MODULATION OF ALTERNATIVE SPLICING

#5
20250364075
2025-11-27

COMPUTATIONAL METHODS TO IDENTIFY ALLOSTERIC SITES THAT MODULATE ENZYME ACTIVITY

#6
20250361284
2025-11-27

TRANSPOSASE FUSION PROTEINS FOR USE IN CELL AND GENE THERAPY

#7
20250321223
2025-10-16

ENGINEERING CHEMICALLY INDUCIBLE SPLIT PROTEIN ACTUATORS (CISPA)

#8
20250313803
2025-10-09

Compositions and Methods for Cancer Immunotherapy

#9
20250207109
2025-06-26

ENGINEERED SPLIT DHFR-BASED METHODS AND SYSTEMS FOR SELECTING CELLS THAT HAVE STABLY ACQUIRED A HETEROLOGOUS POLYNUCLEOTIDE

#10
20250197869
2025-06-19

Ribosome-Mediated Incorporation of Peptides and Peptidomimetics

#11
20250019672
2025-01-16

DESTABILISING DOMAINS FOR CONDITIONALLY STABILISING A PROTEIN

#12
20240401004
2024-12-05

DHFR TUNABLE PROTEIN REGULATION

#13
20240384007
2024-11-21

COMPOSITIONS AND METHODS FOR SELECTIVE PROTEIN DEGRADATION

#14
20240226100
2024-07-11

CONTROL OF PROTEIN EXPRESSION WITH TMP-PROTAC COMPOUNDS

#15
20240101972
2024-03-28

METHODS OF REGULATING ADENO-ASSOCIATED VIRUS PRODUCTION

#16
20240011010
2024-01-11

SYNTHETIC PROTEIN-LEVEL NEURAL NETWORK IN MAMMALIAN CELLS

#17
20230257756
2023-08-17

REAL-TIME CELLULAR THERMAL SHIFT ASSAY (RT-CETSA) FOR RESEARCH AND DRUG DISCOVERY

#18
20230235278
2023-07-27

Protein enriched microvesicles and methods of making and using the same

#19
20230092895
2023-03-23

TANDEM CD19 CAR-BASED COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY

#20
20230056856
2023-02-23

COMPOSITIONS AND METHODS FOR TUNABLE REGULATION OF TRANSCRIPTION

#21
20230046194
2023-02-16

Ribosome-mediated incorporation of peptides and peptidomimetics

#22
20220333137
2022-10-20

METHODS AND PRODUCTS FOR PRODUCING ENGINEERED MAMMALIAN CELL LINES WITH AMPLIFIED TRANSGENES

#23
20220282278
2022-09-08

REGULATION OF GENE EXPRESSION BY APTAMER-MEDIATED MODULATION OF ALTERNATIVE SPLICING

#24
20220213449
2022-07-07

DHFR tunable protein regulation

#25
20220175781
2022-06-09

CD40L COMPOSITIONS AND METHODS FOR TUNABLE REGULATION

#26
20220169993
2022-06-02

Destabilising domains for conditionally stabilising a protein

#27
20220133917
2022-05-05

Small Molecules for Dual Function Positron Emission Tomography (PET) and Cell Suicide Switches

#28
20220112470
2022-04-14

SYSTEMS AND METHODS FOR METABOLIC ENGINEERING

#29
20220042036
2022-02-10

METHODS AND COMPOSITIONS FOR PREPARING SURFACTANT PROTEIN D (SP-D)

#30
20220041999
2022-02-10

METHODS TO ENRICH GENETICALLY ENGINEERED T CELLS

#31
20210317435
2021-10-14

DOUBLE KNOCK-OUT CHO CELL LINE METHOD OF ITS GENERATION AND PRODUCING THERAPEUTIC PROTEINS THEREFROM

#32
20210317168
2021-10-14

Complement Component 1s (C1s) Deficient Cells for Production of Vaccines and Biopharmaceutical Proteins

#33
20210254079
2021-08-19

Vector including a translation-impaired dihydrofolate reductase gene cassette and ubiquitously acting chromatin opening element

#34
20210238570
2021-08-05

Programmable protein circuits in living cells

#35
20210139872
2021-05-13

CRISPR HAVING OR ASSOCIATED WITH DESTABILIZATION DOMAINS

#36
20210130845
2021-05-06

COMPOSITIONS AND METHODS FOR CHIMERIC LIGAND RECEPTOR (CLR)-MEDIATED CONDITIONAL GENE EXPRESSION

#37
20210110884
2021-04-15

SYSTEMS AND METHODS FOR ENGINEERING ENZYMES

#38
20210054346
2021-02-25

SELECTION METHODS FOR GENETICALLY-MODIFIED T CELLS

#39
20200407747
2020-12-31

METHODS, COMPOSITIONS AND CELLS FOR PREPARING SURFACTANT PROTEIN D (SP-D)

#40
20200377852
2020-12-03

Protein enriched microvesicles and methods of making and using the same

#41
20200370057
2020-11-26

Ribosome-mediated incorporation of peptides and peptidomimetics

#42
20200339704
2020-10-29

Compositions and methods for selective protein degradation

#43
20200188436
2020-06-18

Compositions and Methods for Cancer Immunotherapy

#44
20200181673
2020-06-11

Sensors, methods and kits for detecting NADPH based on resonance energy transfer

#45
20200172879
2020-06-04

DHFR tunable protein regulation

#46
20200087683
2020-03-19

Regulation of gene expression by aptamer-mediated modulation of alternative splicing

#47
20190300864
2019-10-03

DESTABILISING DOMAINS FOR CONDITIONALLY STABILISING A PROTEIN

#48
20190249199
2019-08-15

METHODS AND PRODUCTS FOR PRODUCING ENGINEERED MAMMALIAN CELL LINES WITH AMPLIFIED TRANSGENES

#49
20190225972
2019-07-25

METHODS FOR IMPROVING RECOMBINANT PROTEIN EXPRESSION

#50
20190083449
2019-03-21

COMBINATION THERAPY WITH AN ANTI-HYALURONAN AGENT AND THERAPEUTIC AGENT

#51
20190078099
2019-03-14

CELL LINE FOR RECOMBINANT PROTEIN AND/OR VIRAL VECTOR PRODUCTION

#52
20190071694
2019-03-07

Methods and compositions for preparing surfactant protein D (SP-D)

#53
20190071693
2019-03-07

Methods, compositions and cells for preparing surfactant protein D (SP-D)

#54
20190070321
2019-03-07

Small molecules for dual function positron emission tomography (PET) and cell suicide switches

#55
20180298349
2018-10-18

Selection methods for genetically-modified T cells

#56
20180265891
2018-09-20

Expression vector system comprising two selection markers

#57
20180163233
2018-06-14

METHODS AND PRODUCTS FOR PRODUCING ENGINEERED MAMMALIAN CELL LINES WITH AMPLIFIED TRANSGENES

#58
20180010146
2018-01-11

Regulation of gene expression by aptamer-mediated modulation of alternative splicing

#59
20180002709
2018-01-04

Ribosome-mediated incorporation of peptides and peptidomimetics

#60
20170306307
2017-10-26

CRISPR HAVING OR ASSOCIATED WITH DESTABILIZATION DOMAINS

#61
20170290796
2017-10-12

Combination therapy with an anti-hyaluronan agent and therapeutic agent

#62
20170130197
2017-05-11

Protein enriched microvesicles and methods of making and using the same

#63
20170067077
2017-03-09

Expression vector system comprising two selection markers

#64
20170009199
2017-01-12

Chemically defined cell culture media additive

#65
20160215278
2016-07-28

METHOD FOR MASS PRODUCTION OF FACTOR VII/VIIA DERIVATIVES

#66
20160076043
2016-03-17

Methods for improving recombinant protein expression

#67
20160017372
2016-01-21

Methods and products for producing engineered mammalian cell lines with amplified transgenes

#68
20150343082
2015-12-03

Methods of making and using chemically self assembled-nanorings

#69
20150337331
2015-11-26

Expression vector

#70
20150024485
2015-01-22

Puro-DHFR quadrifunctional marker and its use in protein production

#71
20130302400
2013-11-14

Combination therapy with an anti-hyaluronan agent and therapeutic agent

#72
20120214203
2012-08-23

Methods for improving recombinant protein expression

#73
20110306092
2011-12-15

Expression vector system comprising two selection markers

#74
20110143359
2011-06-16

Method for Identifying Drug-Sensitizing Antisense DNA Fragments and Use Thereof

#75
20100197012
2010-08-05

Application of RNA Interference Targeting dhfr Gene, to Cell for Producing Secretory Protein

#76
20100167298
2010-07-01

PURO-DHFR quadrifunctional marker and its use in protein production

#77
20090148935
2009-06-11

Application of RNA Interference Targeting DHFR Gene, to Cell for Protein Production

#78
20070254338
2007-11-01

Method for making recombinant protein using complementation dependent DHFR mutants

#79
20070218481
2007-09-20

Method for identifying drug-sensitizing antisense DNA fragments and use thereof

#80
20060223144
2006-10-05

Method for mass production of human pollicle stimulating hormone