116170 ⎘
Hydrolases acting on ester bonds (3.1)
Sub-classes:MULTI-REGION NUCLEIC ACID ANALYSIS
#2Template Switch-Based Methods for Producing a Product Nucleic Acid
#3NUCLEIC ACID ENRICHMENT AND DETECTION
#4ANTIBACTERIAL PHAGE, THERAPEUTIC COMPOSITION, BACTERICIDAL AGENT, FOOD, BACTERIA IDENTIFICATION KIT, THERAPEUTIC COMPOSITION MANUFACTURING METHOD, BACTERIA ELIMINATION METHOD, BACTERIA IDENTIFICATION METHOD, AND ANIMAL THERAPEUTIC METHOD
#5MULTIPLEX PCR REACTION SYSTEM
#6PADLOCK BLOCKING OLIGONUCLEOTIDE
#7METHODS AND ORGANISMS WITH INCREASED CARBON FLUX EFFICIENCIES
#8ENGINEERED BACTERIA AND METHODS OF PRODUCING SUSTAINABLE BIOMOLECULES
#9METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
#10CRISPR HYBRID DNA/RNA POLYNUCLEOTIDES AND METHODS OF USE
#11Methods and Compositions for the Simultaneous Identification and Mapping of DNA Methylation
#12Animal Feeds and Feed Premixes Containing Betaine Hydrochloride and a Phytase
#13METHODS FOR PRODUCING ANTIGEN-BINDING PROTEINS AGAINST FOREIGN ANTIGENS
#14ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION
#15SEQUENCE SPECIFIC ANTIMICROBIALS
#16CAS VARIANTS FOR GENE EDITING
#17CRISPR ENZYME MUTATIONS REDUCING OFF-TARGET EFFECTS
#18METHODS FOR VARIANT DETECTION
#19RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES
#20METHODS FOR VARIANT DETECTION
#21METHODS, COMPOSITIONS, AND DEVICES FOR SUPPLYING DIETARY FATTY ACID NEEDS
#22DELIVERY AND USE OF THE CRISPR-CAS SYSTEMS, VECTORS AND COMPOSITIONS FOR HEPATIC TARGETING AND THERAPY
#23RECRUITMENT OF DNA POLYMERASE FOR TEMPLATED EDITING
#24Cas9-Cas9 Fusion Proteins
#25Guide RNA That Targets A Mutant Human Guanylate Cyclase 2A Allele
#26RNA-Guided Targeting of Genetic and Epigenomic Regulatory Proteins to Specific Genomic Loci
#27Adeno-Associated-Virus Rep Sequences, Vectors and Viruses
#28METHODS FOR VARIANT DETECTION
#29METHODS, COMPOSITIONS, AND DEVICES FOR SUPPLYING DIETARY FATTY ACID NEEDS
#30METHODS, COMPOSITIONS, AND DEVICES FOR SUPPLYING DIETARY FATTY ACID NEEDS
#31RNA-Guided Human Genome Engineering
#32RNA-Guided Human Genome Engineering
#33Animal Feeds and Feed Premixes Containing Betaine Hydrochloride and a Phytase
#34Increasing Specificity for RNA-Guided Genome Editing
#35ENZYMES, MICRO-ORGANISMS AND USES THEREOF, AND A METHOD OF DEGRADING HYDROCARBON CHAINS
#36EXPRESSION AND PURIFICATION OF CAS ENZYMES
#37RNA-Guided Transcriptional Regulation
#38CHIMERIC ALKALINE PHOSPHATASE-LIKE PROTEINS
#39HEMOCOMPATIBLE MESENCHYMAL STEM CELLS, PREPARATION METHOD THEREFOR AND USE THEREOF
#40Sequence specific antimicrobials
#41TARGETED INSERTION VIA TRANSPORTATION
#42Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
#43MULTIPLEX RNA TARGETING
#44ENZYMES, MICRO-ORGANISMS AND USES THEREOF, AND A METHOD OF DEGRADING HYDROCARBON CHAINS
#45METHODS AND ORGANISMS WITH INCREASED CARBON FLUX EFFICIENCIES
#46CHIMERIC PROTEINS AND METHODS OF REGULATING GENE EXPRESSION
#47HUMAN HEMATOPOIETIC STEM CELL HAVING A MODIFIED BCL11A GENE AND METHODS OF MAKING THE CELL
#48Methods, compositions, and devices for supplying dietary fatty acid needs
#49Systems, methods and compositions for sequence manipulation with optimized functional CRISPR-Cas systems
#50RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES
#51Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing
#52CATION CHELATOR HOT START
#53COMPOSITIONS AND METHODS OF USE OF CRISPR-CAS SYSTEMS IN NUCLEOTIDE REPEAT DISORDERS
#54RNA-guided human genome engineering
#55Orthogonal Cas9 Proteins for RNA-Guided Gene Regulation and Editing
#56Esterases and uses thereof
#57CRISPR HYBRID DNA/RNA POLYNUCLEOTIDES AND METHODS OF USE
#58Guide RNA that targets a mutant human inosine monophosphate deyhydrogenase I allele
#59Guide RNA that targets a mutant human guanylate cyclase 2A allele
#60RNA-guided transcriptional regulation
#61ENGINEERED BACTERIA AND METHODS OF PRODUCING SUSTAINABLE BIOMOLECULES
#62Compositions and Methods for Gene Editing
#63COMPOSITIONS AND METHODS FOR GENE EDITING
#64SWITCHABLE CAS9 NUCLEASES AND USES THEREOF
#65Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
#66CRISPR/CAS-MEDIATED GENE CONVERSION
#67Methods, compositions, and devices for supplying dietary fatty acid needs
#68Methods, compositions, and devices for supplying dietary fatty acid needs
#69Methods, compositions, and devices for supplying dietary fatty acid needs
#70METHODS AND COMPOSITIONS FOR THE TREATMENT OF FABRY DISEASE
#71METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
#72Sequence specific antimicrobials
#73Sequence specific antimicrobials
#74Sequence specific antimicrobials
#75Inbred watermelon line WDL0090
#76Cas9 fusion molecules, gene editing systems, and methods of use thereof
#77RNA-guided human genome engineering
#78METHODS FOR PRODUCING ANTIGEN-BINDING PROTEINS AGAINST FOREIGN ANTIGENS
#79HIGH THROUGHPUT GENE EDITING SYSTEM AND METHOD
#80Engineered CRISPR-Cas9 nucleases with altered PAM specificity
#81Sequence specific antimicrobials
#82CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING USHER SYNDROME AND RETINITIS PIGMENTOSA
#83Cas variants for gene editing
#84RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
#85PREVENTION OF MUSCULAR DYSTROPHY BY CRISPR/CAS9-MEDIATED GENE EDITING
#86METHODS FOR VARIANT DETECTION
#87CAS9-CAS9 FUSION PROTEINS
#88CRISPR-BASED GENOME MODIFICATION AND REGULATION
#89Methods of use of CRISPR CPF1 hybrid DNA/RNA polynucleotides
#90DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF THE CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETING DISORDERS AND DISEASES USING VIRAL COMPONENTS
#91Engineered CRISPR-Cas9 Nucleases
#92Modulators of CAS9 polypeptides and methods of use thereof
#93Sequence specific antimicrobials
#94DELIVERY OF NEGATIVELY CHARGED PROTEINS USING CATIONIC LIPIDS
#95Animal feeds and feed premixes containing betaine hydrochloride and a phytase
#96ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS WITH NEW ARCHITECTURES FOR SEQUENCE MANIPULATION
#97COMPOSITIONS AND METHODS OF USE OF CRISPR-CAS SYSTEMS IN NUCLEOTIDE REPEAT DISORDERS
#98Nuclease profiling system
#99Use of Polypeptide
#100TYPE V CRISPR/NUCLEASE-SYSTEM FOR GENOME EDITING IN PLANT CELLS
#101Template Switch-Based Methods for Producing a Product Nucleic Acid
#102RNA-Guided Human Genome Engineering
#103TARGETED TREATMENT OF LEBER CONGENITAL AMOUROSIS
#104Methods, compositions, and devices for supplying dietary fatty acid needs
#105CRISPR-BASED GENOME MODIFICATION AND REGULATION
#106Recruitment of DNA polymerase for templated editing
#107ANTIBACTERIAL PHAGE, THERAPEUTIC COMPOSITION, BACTERICIDAL AGENT, FOOD, BACTERIA IDENTIFICATION KIT, THERAPEUTIC COMPOSITION MANUFACTURING METHOD, BACTERIA ELIMINATION METHOD, BACTERIA IDENTIFICATION METHOD, AND ANIMAL THERAPEUTIC METHOD
#108Method for detecting on-target and predicted off-target genome editing events
#109Gene editing method using virus
#110NOVEL CAS12B ENZYMES AND SYSTEMS
#111CRISPR therapy
#112MRNA driven expression of RNA editors for treatment of pathologies
#113Esterases and uses thereof
#114Chimeric alkaline phosphatase-like proteins
#115Sequence specific antimicrobials
#116METHODS AND ORGANISMS WITH INCREASED CARBON FLUX EFFICIENCIES
#117Methods for engineering T cells for immunotherapy by using RNA-guided Cas nuclease system
#118Gene editing methods with increased knock-in efficiency
#119Compositions and methods for gene editing
#120ANTI-HBV COMBINATION THERAPIES INVOLVING SPECIFIC ENDONUCLEASES
#121Phosphorus-sparing nutritional composition
#122Increasing specificity for RNA-guided genome editing
#123COMPOSITIONS AND METHODS FOR GENE EDITING BY TARGETING FIBRINOGEN-ALPHA
#124Optimized small guide RNAs and methods of use
#125Methods of enhancing homeostatic capacity in a subject by increasing homeostatic system component responsiveness, and devices for use in practicing the same
#126TRANSDUCTION BUFFER
#127Compositions of and methods for in vitro viral genome engineering
#128CRISPR-BASED GENOME MODIFICATION AND REGULATION
#129Chimeric proteins and methods of regulating gene expression
#130Sequence specific antimicrobials
#131Sequence specific antimicrobials
#132RIBONUCLEOPROTEIN TRANSFECTION AGENTS
#133RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES
#134CRISPR-RELATED METHODS AND COMPOSITIONS
#135RNA-GUIDED GENE EDITING AND GENE REGULATION
#136METHODS AND COMPOSITIONS FOR SEQUENCES GUIDING CAS9 TARGETING
#137RNA-GUIDED GENE EDITING AND GENE REGULATION
#138COMPOSITIONS AND METHODS FOR INHIBITION OF ALPHAVIRUS INFECTION
#139Engineered CRISPR-Cas9 nucleases with altered PAM specificity
#140Engineered CRISPR-Cas9 nucleases with altered PAM specificity
#141Delivery and use of the CRISPR-CAS systems, vectors and compositions for hepatic targeting and therapy
#142Cation chelator hot start
#143Method of target cleaving using CRISPR hybrid DNA/RNA polynucleotides
#144Methods and products for expressing proteins in cells
#145DELIVERY SYSTEM FOR FUNCTIONAL NUCLEASES
#146Compositions for linking DNA-binding domains and cleavage domains
#147RNA-Guided Human Genome Engineering
#148RNA-Guided Transcriptional Regulation
#149Mutant Cas9 proteins
#150SEQUENCE SPECIFIC ANTIMICROBIALS
#151Sequence specific antimicrobials
#152Methods and compositions for targeted single-stranded cleavage and targeted integration
#153Methods for engineering T cells for immunotherapy by using RNA-guided Cas nuclease system
#154Switchable CAS9 nucleases and uses thereof
#155NANOS knock-out that ablates germline cells
#156Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing
#157Methods for engineering T cells for immunotherapy by using RNA-guided Cas nuclease system
#158Method for Fragmenting Genomic DNA Using CAS9
#159Compositions and methods for detecting nicking enzyme and polymerase activity using a substrate molecule
#160Engineered CRISPR-Cas9 nucleases
#161Engineered CRISPR-Cas9 nucleases with altered PAM specificity
#162CRISPR-BASED GENOME MODIFICATION AND REGULATION
#163Systems, methods and compositions for sequence manipulation with optimized functional CRISPR-Cas systems
#164CRISPR enzyme mutations reducing off-target effects
#165Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
#166CHIMERIC PROTEINS AND METHODS OF REGULATING GENE EXPRESSION
#167Use of enzymes with a wide pH activity range as medicaments for promoting digestion
#168CRISPR hybrid DNA/RNA polynucleotides and methods of use
#169Methods and products for expressing proteins in cells
#170RNA-guided human genome engineering
#171Methods and products for expressing proteins in cells
#172Methods and products for expressing proteins in cells
#173Methods and products for expressing proteins in cells
#174Methods and products for expressing proteins in cells
#175Methods and products for expressing proteins in cells
#176Methods and products for expressing proteins in cells
#177Methods and products for expressing proteins in cells
#178Methods and products for expressing proteins in cells
#179RNA-guided transcriptional regulation
#180NOVEL RECOMBINANT ADENO-ASSOCIATED VIRUS CAPSIDS WITH ENHANCED HUMAN SKELETAL MUSCLE TROPISM
#181RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
#182Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
#183Mutant Cas9 proteins
#184Engineered transcription activator-like effector (TALE) domains and uses thereof
#185Methods and products for expressing proteins in cells
#186Transcriptional regulatory fusion polypeptide
#187Animal feeds and feed premixes containing betaine hydrochloride and a phytase
#188Cas variants for gene editing
#189Compositions of and methods for in vitro viral genome engineering
#190Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of ASGPR
#191FAD2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
#192Adeno-associated-virus Rep sequences, vectors and viruses
#193CAS9-CAS9 fusion proteins
#194ORAL VETERINARY PHARMACEUTICAL AND NUTRACEUTICAL COMPOSITIONS
#195RNA-guided human genome engineering
#196RNA-guided human genome engineering
#197Methods of generating and screening for lytic chimeric polypeptides
#198COMPOSITIONS AND METHODS TO TREAT HERPES SIMPLEX VIRUS INFECTIONS
#199METHODS FOR VARIANT DETECTION
#200Compositions of and methods for in vitro viral genome engineering
#201COMPOSITIONS AND METHODS FOR CELL TARGETED HPV TREATMENT
#202Methods of transcription activator like effector assembly
#203GENE EDITING FOR IMMUNOLOGICAL DESTRUCTION OF NEOPLASIA
#204Compositions and methods of use of CRISPR-Cas systems in nucleotide repeat disorders
#205Engineered nucleases useful for treatment of hemophilia A
#206Particles coated with catalysts useful for splicing nucleic acids
#207Method For In Vivo High-Throughput Evaluating Of RNA-Guided Nuclease Activity
#208Cas9 fusion molecules, gene editing systems, and methods of use thereof
#209Half-coating method for nanoparticles
#210NOVEL CAS SYSTEMS AND METHODS OF USE
#211Coexpression of CAS9 and TREX2 for targeted mutagenesis
#212Engineered CRISPR-Cas9 nucleases
#213COMPOSITIONS AND METHODS COMPRISING SEQUENCES HAVING MEGANUCLEASE ACTIVITY
#214Mutant Cas9 proteins
#215Methods and compositions for targeted single-stranded cleavage and targeted integration
#216CRISPR/Cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
#217Crispr enzyme mutations reducing off-target effects
#218Chimeric alkaline phosphatase-like proteins
#219Crispr enzyme mutations reducing off-target effects
#220Preparation method of hydrogel based on decellularized tissue using supercritical fluid-organic solvent system
#221Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing
#222RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES
#223RNA-guided gene editing and gene regulation
#224Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of ASGPR
#225High-throughput screening of regulatory element function with epigenome editing technologies
#226Engineered CRISPR-Cas9 nucleases with altered PAM specificity
#227Methods, compositions, and devices for supplying dietary fatty acid needs
#228Chimeric proteins and methods of regulating gene expression
#229Methods, compositions, and devices for supplying dietary fatty acid needs
#230Methods for engineering T cells for immunotherapy by using RNA-guided Cas nuclease system
#231Nuclease-mediated regulation of gene expression
#232Delivery of negatively charged proteins using cationic lipids
#233FAD2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
#234Engineered CRISPR-Cas9 nucleases
#235Increasing specificity for RNA-guided genome editing
#236Method of diagnosing preeclampsia or pregnancy-induced hypertension
#237Cells containing CRISPR hybrid DNA/RNA polynucleotides
#238Compositions and methods comprising sequences having meganuclease activity
#239Methods and compositions for the treatment of Fabry disease
#240Methods of specifically labeling nucleic acids using CRISPR/Cas
#241Use of enzymes with a wide pH activity range as medicaments for promoting digestion
#242Method for Producing DHA-Containing Glyceride-Containing Composition
#243Compositions and methods for detecting nicking enzyme and polymerase activity using a substrate molecule
#244TARGETED TREATMENT OF LEBER CONGENITAL AMOUROSIS
#245SYSTEMS AND METHODS FOR GENOME MODIFICATION AND REGULATION
#246Methods and products for expressing proteins in cells
#247Methods, compositions, and devices for supplying dietary fatty acid needs
#248Liquid detergent composition comprising an encapsulated enzyme
#249METHODS FOR BREAKING IMMUNOLOGICAL TOLERANCE USING MULTIPLE GUIDE RNAS
#250Engineered CRISPR-Cas9 nucleases with altered PAM specificity
#251Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing
#252Efficient delivery of therapeutic molecules in vitro and in vivo
#253Compositions and methods for producing plants resistant to glyphosate herbicide
#254Lipase variants and polynucleotides encoding same
#255Bacteria identification and antibiotic susceptibility profiling device
#256COMPOSITIONS COMPRISING RECOMBINANT BACILLUS CELLS AND A FUNGICIDE
#257Bacteriophage engineering methods
#258DIRECT CRISPR SPACER ACQUISITION FROM RNA BY A REVERSE-TRANSCRIPTASE-CAS1 FUSION PROTEIN
#259METHODS FOR VARIANT DETECTION
#260ONCOVIRAL TREATMENT WITH NUCLEASE AND CHEMOTHERAPEUTIC
#261Methods and compositions for blocking off-target nucleic acids from cleavage by CRISPR proteins
#262MODIFIED ANTIVIRAL NUCLEASE
#263Methods, compositions, and devices for supplying dietary fatty acid needs
#264Methods, compositions, and devices for supplying dietary fatty acid needs
#265CONTROLLED-RELEASE AND STRATIFIED CYCLODEXTRIN INCLUSION COMPLEX VEHICLES
#266Compositions for linking DNA-binding domains and cleavage domains
#267Detergents and Compositions with Enzymatic Polymer Particles
#268Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis
#269Chimeric proteins and methods of regulating gene expression
#270METHODS FOR USING A 5'-EXONUCLEASE TO INCREASE HOMOLOGOUS RECOMBINATION IN EUKARYOTIC CELLS
#271Compositions And Methods For Genetically Modifying Yeast
#272METHODS RELATING TO NUCLEIC ACID SEQUENCE EDITING
#273Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of ASGPR
#274Recombinant adeno-associated virus capsids with enhanced human skeletal muscle tropism
#275Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
#276Methods of Enhancing Homeostatic Capacity in a Subject by Increasing Homeostatic System Component Responsiveness, and Devices for Use in Practicing the Same
#277Coffee pulp preservation and extraction process
#278NANOS KNOCK-OUT THAT ABLATES GERMLINE CELLS
#279Independently inducible system of gene expression
#280Sympathetic printed-matter and method of producing the same
#281CRISPR hybrid DNA/RNA polynucleotides and methods of use
#282NOVEL ALTERNATIVELY SPLICED TRANSCRIPTS AND USES THEREOF FOR IMPROVEMENT OF AGRONOMIC CHARACTERISTICS IN CROP PLANTS
#283RNA Modification to Engineer Cas9 Activity
#284NUCLEIC ACID ENRICHMENT USING CAS9
#285Ribonucleoprotein transfection agents
#286ORAL VETERINARY PHARMACEUTICAL AND NUTRACEUTICAL COMPOSITIONS
#287TRANSGENIC NUCLEASE SYSTEMS AND METHODS
#288Targeted modification of malate dehydrogenase
#289COMPOSITIONS AND METHODS FOR LATENT VIRAL TRANSCRIPTION REGULATION
#290DELIVERY METHODS AND COMPOSITIONS
#291Modifying messenger RNA stability in plant transformations
#292Engineered CRISPR-Cas9 nucleases
#293Use of polypeptide
#294CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
#295Stitched polypeptides
#296METHODS AND COMPOSITIONS FOR PRODUCING MALE STERILE PLANTS
#297DIRECTED NUCLEIC ACID REPAIR
#298Engineered CRISPR-Cas9 nucleases
#299Method for fragmenting genomic DNA using CAS9
#300Fad2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks