David Baker

De novo designed modular peptide binding proteins by superhelical matching

SYSTEM AND METHOD TO DIRECT THE DIFFERENTIATION OF PLURIPOTENT STEM CELL-DERIVED ODONTOBLASTS

BIOLOGICALLY RELEVANT ORTHOGONAL CYTOKINE/RECEPTOR PAIRS

HIGH THROUGHPUT PROTEIN-PROTEIN INTERACTION SCREENING IN YEAST LIQUID CULTURE

De novo designed chlorophyll special pair proteins

Polypeptide Assemblies and Methods for the Production Thereof

WNT SIGNALING AGONIST MOLECULES

Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus F proteins and their use

POTENT AND SELECTIVE HDAC6 MACROCYCLIC INHIBITORS

DE NOVO DESIGNED BINDERS TARGETING HUMAN EPCAM AND PDL1 RECEPTORS

De Novo Designed Stimulus-responsive Two-state Hinge Proteins

SECRETION-OPTIMIZED DE NOVO DESIGNED PROTEIN NANOPARTICLES FOR EUKARYOTIC EXPRESSION AND GENETIC DELIVERY

De novo Design of Protein Switches

Split interleukin mimetics and their use

Computational Design of Self-Assembling Cyclic Protein Homo-oligomers

DE NOVO DESIGN OF POTENT AND SELECTIVE INTERLEUKIN MIMETICS

De Novo Designed Cortisol Biosensor

DE NOVO DESIGNED MACROCYCLIC OLIGOAMIDES

POTENT AND STABLE POLYPEPTIDE ANALOGUES VIA SERINE/THREONINE LIGATION

DE NOVO DESIGNED LUCIFERASE

COMPOSITIONS AND METHODS FOR TREATING CELIAC SPRUE DISEASE

De novo designed sequence-specific DNA binding proteins

DESIGNED ANTIBODY-BOUND NANOPARTICLES

FRIZZLED-SPECIFIC WNT AGONISTS AND ANTAGONISTS

WNT SIGNALING AGONIST MOLECULES

Compositions and Methods For Semi-Automated Protein Production

De Novo Designed alpha(5) beta(1) Integrin selective minibinders

MULTIPLE DE NOVO DESIGNED PROTEIN BINDING PROTEINS

MODULAR RECONFIGURABLE ASYMMETRIC PROTEIN ASSEMBLIES

SILK FIBROIN TO STABILIZE "DE NOVO" SENSING PROTEINS

HIGH THROUGHPUT PROTEIN-PROTEIN INTERACTION SCREENING IN YEAST LIQUID CULTURE

Compositions and Methods for Treating Celiac Sprue Disease

SELF-ASSSEMBLING NANOSTRUCTURE VACCINES

Compositions and Methods for Treating Celiac Sprue Disease

Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus F proteins and their use

ORTHOGONAL PROTEIN HETERODIMERS

De novo design of potent and selective interleukin mimetics

Self-Assembling Protein Nanostructures

De novo design of obligate ABC heterotrimeric proteins

De Novo Designed Homo-Oligomeric Protein Assemblies

De novo designed rotor (axle:ring) protein assemblies

Scaffolding protein functional sites using deep learning

Structured Symmetric Cyclic Peptides as Ligands for Metal Organic Frameworks

HUMAN IL23 RECEPTOR BINDING POLYPEPTIDES

DESIGNED ANTIBODY-BOUND NANOPARTICLES

Polypeptide Assemblies and Methods for the Production Thereof

MACROCYCLIC POLYPEPTIDES

De novo designed NTF2-like scaffolds for de novo design of enzymes and small molecule binders

TRANSMEMBRANE BETA BARREL PROTEINS

TWO COMPONENT CO-ASSEMBLING TWO DIMENSIONAL PROTEIN STRUCTURES

MODULAR AND GENERALIZABLE BIOSENSOR PLATFORM BASED ON DE NOVO DESIGNED PROTEIN SWITCHES

De Novo Design of Immunoglobulin-like Domains

DE NOVO DESIGNED MIXED CHIRALITY PEPTIDE MACROCYCLES WITH INTERNAL SYMMETRY

Repeat Protein Architectures

Transferrin Receptor Binding Protein

SARS-COV-2 inhibitors

ANTIBODY-BOUND NANOPARTICLES

DE NOVO DESIGNED ALPHA-HELICAL PROTEIN CHANNELS

POLYPEPTIDES FOR USE IN SELF-ASSEMBLING PROTEIN NANOSTRUCTURES

RIGID HELICAL JUNCTIONS FOR MODULAR REPEAT PROTEIN SCULPTING AND METHODS OF USE

COMPOSITIONS AND METHODS FOR TREATING CELIAC SPRUE DISEASE

De novo designed protein homodimers containing tunable symmetric pockets

MULTIPARTITE AND CIRCULARLY PERMUTED BETA-BARREL POLYPEPTIDES AND METHODS FOR THEIR USE

BIOLOGICALLY RELEVANT ORTHOGONAL CYTOKINE/RECEPTOR PAIRS

COMPUTATIONAL DESIGN OF ALPHA(V) BETA (6) INTEGRIN BINDING PROTEINS

Ultraspecific Cell Targeting Using De Novo Designed Co-Localization Dependent Protein Switches

De novo design of potent and selective interleukin mimetics

DE NOVO DESIGN OF PHOSPHORYLATION INDUCIBLE PROTEIN SWITCHES (PHOSPHO-SWITCHES)

LOCKR-MEDIATED RECRUITMENT OF CAR T CELLS

WORMS Scaffolds: Multi-scale protein complexes

AMANTADINE BINDING PROTEIN

Precise Gene Activation Via Novel Designed Proteins Mediating Epigenetic Remodeling

Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus F proteins and their use

SELF-ASSEMBLING 2D ARRAYS WITH DE NOVO PROTEIN BUILDING BLOCKS

DE NOVO DESIGN OF TUNABLE PH-DRIVEN CONFORMATIONAL SWITCHES

CAGED-DEGRON-BASED MOLECULAR FEEDBACK CIRCUITS AND METHODS OF USING THE SAME

ORTHOGONAL PROTEIN HETERODIMERS

DE NOVO DESIGN OF PROTEIN SWITCHES FOR TUNABLE CONTROL OF PROTEIN DEGRADATION

De novo design of potent and selective interleukin mimetics

High throughput protein-protein interaction screening in yeast liquid culture

REAGENTS AND METHODS FOR CONTROLLING PROTEIN FUNCTION AND INTERACTION

Split interleukin mimetics and their use

ORTHOGONAL PROTEIN HETERODIMERS

WNT SIGNALING AGONIST MOLECULES

SELF-ASSEMBLING PROTEIN STRUCTURES AND COMPONENTS THEREOF

Transmembrane polypeptides

Orthogonal protein heterodimers

Polypeptide Assemblies and Methods for the Production Thereof

SELF-ASSEMBLING PROTEIN HOMO-POLYMERS

Frizzled specific Wnt agonists and antagonists

FOLDED AND PROTEASE-RESISTANT POLYPEPTIDES

Compositions and Methods for Treating Celiac Sprue Disease

Computational design of self-assembling cyclic protein homo-oligomers

Compositions and methods for treating celiac sprue disease

Hyperstable Constrained Peptides and Their Design

De novo designed non-local beta sheet proteins

De novo design of protein switches

Polypeptides Capable of Forming Homo-Oligomers with Modular Hydrogen Bond Network-Mediated Specificity and Their Design

Compositions and Methods for Treating Celiac Sprue Disease

High throughput protein-protein interaction screening in yeast liquid culture