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Patent application title:

Pain management

Publication number:

US20050281870A1

Publication date:
Application number:

11/182,325

Filed date:

2005-07-18

Abstract:

The present invention relates to Pain Management and to a process for producing a transdermal pain formulation, in liquid, viscous, or roll on device, including a composition including a. Astragalus at about 10% of the composition b. Cat's Claw at about 10% of the composition c. Mistletoe at about 10% of the composition d. Sheep Sorrel at about 10% of the composition e. Green Tea at about 10% of the composition f. Capsaicin at about 10% of the composition g. Nettle leaf at about 10% of the composition h. Skull cap at about 10% of the composition i. L-Glutamine at bout 10% of the composition j. Fat soluble Ascorbyl Palmitate form of Vitamin C at about 10% of the composition

  • k. In which to the substances in (a) to (j) is added Alcohol-H2O Tincture, in a ration of 1:1:1 on all herbal substances in (a) to (j) and concentrated to about a 50% reduction, and to which a final addition of Ascorbyl Palmitate and L-Glutamine in an ½ half to ½ half ratio to the concentrated tincture, so as to be combined in a predetermined varied quantities of (k), resulting in a liquid, viscous cream form, or roll-on device, with the addition of a Liposomal transdermal carrier.

Inventors:

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Classification:

  1. Human necessities
  2. Medical or veterinary science; hygiene

A61K31/375 »  CPC main

Medicinal preparations containing organic active ingredients; Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin; Lactones Ascorbic acid, i.e. vitamin C; Salts thereof

A61K9/0014 »  CPC further

Medicinal preparations characterised by special physical form; Galenical forms characterised by the site of application Skin, i.e. galenical aspects of topical compositions

A61K9/127 »  CPC further

Medicinal preparations characterised by special physical form; Dispersions; Emulsions Liposomes

A61K31/198 »  CPC further

Medicinal preparations containing organic active ingredients; Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids; Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]

A61K36/18 »  CPC further

Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines Magnoliophyta (angiosperms)

A61K36/185 »  CPC further

Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines; Magnoliophyta (angiosperms) Magnoliopsida (dicotyledons)

A61K36/481 »  CPC further

Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines; Magnoliophyta (angiosperms); Magnoliopsida (dicotyledons); Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae Astragalus (milkvetch)

A61K36/539 »  CPC further

Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines; Magnoliophyta (angiosperms); Magnoliopsida (dicotyledons); Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender Scutellaria (skullcap)

A61K36/74 »  CPC further

Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines; Magnoliophyta (angiosperms); Magnoliopsida (dicotyledons) Rubiaceae (Madder family)

A61K2300/00 »  CPC further

Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups  - 

Description

This is a continuation/divisional of a patent application Ser. No. 10/744,126 with a filing date of Dec. 24, 2003

This invention relates to the control and regulation of pain management. It is common knowledge that all human beings at sometime in their lifetime are afflicted with pain. Consequently, numerous forms of remedies have been proposed and suggested for external body surface use.

The present invention is a transdermal pain formulation. In particular, this inventive formula is designed, for convenience, to be used as a roll on for topical application, in and around the areas of pain.

It should be noted that this formulation could also be in viscous or liquid form, for application as a cream or liquid or spray.

This formula is designed to be used as a roll on for topical application. This inventive transdermal formulation assists to block both inflammatory processes and transmission of pain signals simultaneously. It is also designed to facilitate wound healing and trauma recovery.

These mechanisms include, but are not limited to and may find other applications.

  • 1. Prostaglandin inhibition to reduce inflammation
  • 2. Inhibition of substance P to inhibit pain signal transmission
  • 3. Antioxidant properties
  • 4. Scavenging Hydroxyl Free Radicals
  • 5. Scavenging Superoxide Free Radicals
  • 6. Enhances the ability of Phagocytes
  • 7. Enhances the ability of Macrophages to function as Phagocytes
  • 8. Helps control the release of inflammatory mediators such as eicosanoids and hydrolytic enzymes secreted by macrophages
  • 9. Controls levels of Interleukin 1 and Tumor Necrosis Factor
  • 10. Inhibits the genetic transcription factor that activates TNF-a and IL-1B in synovial tissue
  • 11. Stimulation of the proliferation of Fibroblasts
  • 12. Stimulates the production of Fibroplasia (Connective Tissue produced within the body as part of the healing process for Wounds)
  • 13. Inhibition of COX-1
  • 14. Inhibition of COX-2
  • 15. Inhibition of 5-LO
  • 16. Inhibition of LTC-4

According to the present invention, a transdermal pain formulation composition consists of the following substances including

  • a. Astragalus at 5% to 16% of the total composition,
  • b. Cat's Claw at 6% to 15% of the composition,
  • c. Mistletoe at 5% to 16% of the composition,
  • d. Sheep Sorrell at 5% to 15% of the composition,
  • e. Green Tea at 6% to 16% of the composition,
  • f. Capsaicin at 5% to 15% of the composition,
  • g. Nettle leaf at 5% to 16% of the composition,
  • h. Skullcap at 6% to 15% of the composition,
  • i. L-Glutamine at 6% to 15% of the composition,
  • j. Fat soluble Ascorbyl Palmitate form of Vitamin C 5% to 15% of the composition, and
  • k. A transdermal Libosomal carrier in which substances (a) to (j) are combined with Alcohol-H2O Tincture to constitute active substances whereby to mix with (k) to form a composition mix of the about 40% to 65% of the carrier (k) and about 30 to 50% of the active substances (a) to (j).
    The substances in (a) to (j) constitute the active substances of the total mix. The invention also includes a process for pain formulation composition consisting of the following substances including
  • a. Astragalus at about 10% of the composition
  • b. Cat's Claw at about 10% of the composition
  • c. Mistletoe at about 10% of the composition
  • d. Sheep Sorrel at about 10% of the composition
  • e. Green Tea at about 10% of the composition
  • f. Capsaicin at about 10% of the composition
  • g. Nettle leaf at about 10% of the composition
  • h. Skull cap at about 10% of the composition
  • i. L-Glutamine at about 10% of the composition
  • j. Fat soluble Ascorbyl Palmitate form of Vitamin C at about 10% of the composition
  • k. A transdermal Liposomal carrier adapted to act as a transdermal carrier in which the substances (a) to (j) are combined with Alcohol-H2O Tincture, with a ratio of 1 to 1 to 1 on all herbal components and concentrated to about 50% reduction, to a final addition of Ascorbyl Palmitate and Chondroitin Sulfate A (CSA-A) in a ½ (half) to ½ (half) ratio of the concentrated about 50% reduction, whereby the transdermal carrier at about 60% with about 40% of the total mix of all substances is constituted to form a roll-on application device.

The present invention will now be described, by way of example only as follows:

The present invention has been specifically designed as a roll-on device for topical application in the regions of pain.

This formula is designed to be used as a roll on for topical application. This inventive transdermal formulation assists to both inflammatory processes and transmission of pain signals simultaneously. It is also designed to facilitate wound healing and trauma recovery.

These mechanisms include, but are not limited to and may find other applications.

  • 1. Prostaglandin inhibition to reduce inflammation
  • 2. Inhibition of substance P to inhibit pain signal transmission
  • 3. Antioxidant properties
  • 4. Scavenging Hydroxyl Free Radicals
  • 5. Scavenging Superoxide Free Radicals
  • 6. Enhances the ability of Phagocytes
  • 7. Enhances the ability of Macrophages to function as Phagocytes
  • 8. Helps control the release of inflammatory mediators such as eicosanoids and hydrolytic enzymes secreted by macrophages
  • 9. Controls levels of Interleukin 1 and Tumor Necrosis Factor
  • 10. Inhibits the genetic transcription factor that activates TNF-a and IL-1B in synovial tissue
  • 11. Stimulation if the proliferatin of Fibroblasts
  • 12. Stimulates the production of Fibroplasia (Connective Tissue produces within the body as part of the healing process for Wounds0
  • 13. Inhibition of COX-1
  • 14. Inhibition of COX-2
  • 15. Inhibition of 5-LO
  • 16. Inhibition of LTC-4
    The inventive features of the compositions is constituted by a formulation as follows:
  • a. Astragalus at 5% to 16% of the total composition,
  • b. Cat's Claw at 5% to 15% of the composition,
  • c. Mistletoe at 5% to 16% of the composition,
  • d. Sheep Sorrell at 5% to 15% of the composition,
  • e. Green Tea at 6% to 16% of the composition,
  • f. Capsaicin at 5% to 15% of the composition,
  • g. Nettle leaf at 5% to 16% of the composition,
  • h. Skullcap at 6% to 15% of the composition,
  • i. L-Glutamine at 6% to 15% of the composition,
  • j. Fat soluble Ascorbyl Palmitate form of Vitamin C 5% to 15% of the composition, and
  • k. A transdermal Liposomal carrier in which substances (a) to (j) are combined with Alcohol-H2O Tincture to constitute active substances whereby to mix with (k) to form a composition mix of the about 40% to 65% of the carrier (k) and about 30 to 50% of the active substances (a) to (j).
    The invention also is produced by a process as indicated by for producing a transdermal pain forumlation, in liquid, viscous, or roll on device, including a composition including
  • a. Astragalus at about 10% of the composition
  • b. Cat's Claw at about 10% of the composition
  • c. Mistletoe at about 10% of the composition
  • d. Sheep Sorrel at about 10% of the composition
  • e. Green Tea at about 10% of the composition
  • f. Capsaicin at about 10% of the composition
  • g. Nettle leaf at about 10% of the composition
  • h. Skull cap at about 10% of the composition
  • i. L-Glutamine at about 10% of the composition
  • j. Fat soluble Ascorbyl Palmitate form of Vitamin C at about 10% of the composition
  • k. In which to the substances in (a) to (j) is added Alcohol-H2O Tincture, in a ration of 1:1:1 on all herbal substances in (a) to (j) and concentrated to about a 50% reduction, and to which a final addition of Ascorbyl Palmitate and Chondroitin Sulfate A (CSA-A) in and ½ (half) to ½ (half) ratio to the concentrated tincture, so as to be combined in a predetermined varied quantities of (k), resulting in a liquid, viscous cream form, or roll-on device, with the addition of the Liposomal transdermal carrier.
    Advantageously the present invention includes an addition of Ascorbyl Palmitate and Chondroitin Sulfate A (CSA-A) in a half to half ratio to the active substances (a) to (j).

Conveniently, the invention also includes a further step by the added substances, the substances is (a) to (j) combined with Alcohol-H2O Tincture and condensed and concentrated to a volume of about 50% of the original mix.

Suitably, this invention provides additional features for use as a roll-on the composition is characterized by about 40% active substances and carried in the transdermal Liposomal carrier, which constitutes about 60% of the total mix.

In further form, the invention also includes each substance in (a) to (j) in the total composition with an individual content of about 9% to about 11%.

More, specifically each substance (a) to (j) in the total composition has an individual content of about 10% per substance.

Furthermore, in the present invention each substance (a) to (j) is combined with Alcohol-H2O Tincture, with a ratio of 1:1:1 on all substances, and concentrated to provide a 50% reduction, to which is added Ascorbyl Palmitate an Chondroitin Sulfate A (CSA-A) in an ½ to ½ ratio to the concentrated reduction of all the substances, whereby to provide in a mix with the transdermal carrier, a transdermal composition.

The present invention clearly can be formulated as a liquid or viscous cream or in the form of the roll-on device.

It is extremely advantageous to formulate a composition in which the transdermal carrier constitutes about 60% of the final mix with about 40% of the active concentrated combined substances, whereby to provide the total transdermal composition as a roll-on.

However, it is advantageous to provide, according to the present invention a transdermal composition pain formulation composition consisting of the following substances including

  • a. Astragalus at about 10% of the composition
  • b. Cat's Claw at about 10% of the composition
  • c. Mistletoe at about 10% of the composition
  • d. Sheep Sorrel at about 10% of the composition
  • e. Green Tea at about 10% of the composition
  • f. Capsaicin at about 10% of the composition
  • g. Nettle leaf at about 10% of the composition
  • h. Skull cap at about 10% of the composition
  • i. L-Glutamine at about 10% of the composition
  • j. Fat soluble Ascorbyl Palmitate form of Vitamin C at about 10% of the composition
  • k. A transdermal Liposomal carrier adapted to act as a transdermal carrier in which the substances (a) to (j) are combined with Alcohol-H2O Tincture, with a ratio of 1 to 1 to 1 on all herbal components and concentrated to about 50% reduction, to a final addition of Ascorbyl Palmitate and Chondroitin Sulfate A (CSA-A) in a ½ (half) to ½ (half) ratio of the concentrated about 50% reduction, whereby the transdermal carrier at about 60% with about 40% of the total mix of all substances is constituted to form a roll-on application device.
    The invention furthermore includes a process for producing a transdermal pain formulation, in liquid, viscous, or roll on device, including a composition including
  • a. Astragalus at about 10% of the composition
  • b. Cat's Claw at about 10% of the composition
  • c. Mistletoe at about 10% of the composition
  • d. Sheep Sorrel at about 10% of the composition
  • e. Green Tea at abut 10% of the composition
  • f. Capsaicin at about 10% of the composition
  • g. Nettle leaf at about 10% of the composition
  • h. Skull cap at abut 10% of the composition
  • i. L-Glutamine at about 10% of the composition
  • j. Fat soluble Ascorbyl Palmitate form of Vitamin C at about 10% of the composition
  • k. in which to the substances in (a) to (j) is added Alcohol-H2O Tincture, in a ration of 1:1:1 on all herbal substances in (a) to (j) and concentrated to abut a 50% reduction, and to which a final addition of Ascorbyl Palmitate and Chondroitin Sulfate A (CSA-A) in an ½ half to ½ half ratio to the concentrated tincture, so as to be combined in a predetermined varied quantities of (k), resulting in a liquid, viscous cream form, or roll-on device, with the addition of a Liposomal transdermal carrier.
    Suitably, the process provides a specific ratio of the transdermal carrier that is about 60% of the total substance mix to which is added about 40% of active substances to constitute a roll-on device for external surface use on the body of a human being.

Claims

1. A process for producing a transdermal pain formulation, in liquid, viscous, or roll on device, including a composition constituted by the steps in which to the substances in (a) to (j) as stated below in the composition is added Alcohol-H2O Tincture, in a ratio of 1:1:1 on all herbal substances in (a) to (j) and concentrated to about a 50% reduction, and to which a final addition of Ascorbyl Palmitate and L-Glutamine in an ½ half to ½ half ratio to the concentrated tincture, so as to be combined in a predetermined varied quantities resulting in a liquid, viscous cream form, or roll-on device, with the addition of a Liposomal transdermal carrier, the composition being

a. Astragalus at about 10% of the composition;

b. Cat's Claw at about 10% of the composition;

c. Mistletoe at about 10% of the composition;

d. Sheep Sorrel at about 10% of the composition;

e. Green Tea at about 10% of the composition;

f. Capsaicin at about 10% of the composition;

g. Nettle leaf at about 10% of the composition;

h. Skul cap at about 10% of the composition;

i. L-Glutamine at about 10% of the composition;

j. Fat soluble Ascorbyl Palmitate form of Vitamin C at about 10% of the composition.

2. A process as claimed 1, in which the ratio of the transdermal carrier is about 60% of the total substance mix, to which is added the about 40% of active substances to constitute a roll-on device.

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