Patent Applications published on Jun 27, 2019 - page 11

#3001 ✅ Patent 11,473,057 granted on 2022-10-18
US20190194613A1
Chemistry; metallurgy

Method for obtaining microglia from pluripotent stem cells

#3002
US20190194614A1
Chemistry; metallurgy

A METHOD FOR PREPARING MONONUCLEAR CELLS

#3003 ✅ Patent 11,479,755 granted on 2022-10-25
US20190194615A1
Chemistry; metallurgy

T cell compositions

#3004
US20190194616A1
Chemistry; metallurgy

GENETICALLY-MODIFIED CELLS COMPRISING A MODIFIED HUMAN T CELL RECEPTOR ALPHA CONSTANT REGION GENE

#3005
US20190194617A1
Chemistry; metallurgy

SINGLE- AND MULTI-CHAIN CHIMERIC ANTIGEN RECEPTORS

#3006
US20190194618A1
Chemistry; metallurgy

METHOD FOR MEASURING IMMUNOGENICITY OF PROTEIN AGENT

#3007
US20190194619A1
Chemistry; metallurgy

PLATFORM FOR ACTIVATION AND EXPANSION OF VIRUS-SPECIFIC T-CELLS

#3008
US20190194620A1
Chemistry; metallurgy

Human Extensively Self-Renewing Erythroblasts (ESRE)

#3009
US20190194621A1
Chemistry; metallurgy

MEDIUM FOR CULTURING STEM CELLS, METHOD FOR CULTURING STEM CELLS, GROWTH PROMOTER FOR STEM CELLS, AND CELL COMPOSITION AND METHOD FOR PRODUCING SAME

#3010 ✅ Patent 11,053,476 granted on 2021-07-06
US20190194622A1
Chemistry; metallurgy

Generation of cancer stem cells and use thereof

#3011 ✅ Patent 11,008,550 granted on 2021-05-18
US20190194623A1
Chemistry; metallurgy

Use of RNA for reprogramming somatic cells

#3012 ✅ Patent 11,572,545 granted on 2023-02-07
US20190194624A1
Chemistry; metallurgy

Efficient method for reprogramming blood to induced pluripotent stem cells

#3013 ✅ Patent 11,230,702 granted on 2022-01-25
US20190194625A1
Chemistry; metallurgy

Blood brain barrier model and methods of making and using the same

#3014 ✅ Patent 11,286,465 granted on 2022-03-29
US20190194626A1
Chemistry; metallurgy

ICP0-mediated enhanced expression system

#3015 ✅ Patent 10,900,024 granted on 2021-01-26
US20190194627A1
Chemistry; metallurgy

Method for purifying viruses or virus-like particles using a crosslinked cellulose hydrate membrane

#3016
US20190194628A1
Chemistry; metallurgy

METHODS FOR PRODUCING VIRUS FOR VACCINE PRODUCTION

#3017 ✅ Patent 10,988,743 granted on 2021-04-27
US20190194629A1
Chemistry; metallurgy

Coryneform bacterial transformant and method for producing 4-aminobenzoic acid or salt thereof using same

#3018
US20190194630A1
Chemistry; metallurgy

COMPOSITIONS AND METHODS FOR BIOLOGICAL PRODUCTION OF AMINO ACIDS IN HYDROGENOTROPHIC MICROORGANISMS

#3019 ✅ Patent 10,883,093 granted on 2021-01-05
US20190194631A1
Chemistry; metallurgy

Method for cleaning

#3020 ✅ Patent 11,248,216 granted on 2022-02-15
US20190194632A1
Chemistry; metallurgy

Methods and compositions for genomic editing

#3021
US20190194633A1
Chemistry; metallurgy

COMPOSITIONS, SYSTEMS AND METHODS FOR PROGRAMMING IMMUNE CELL FUNCTION THROUGH TARGETED GENE REGULATION

#3022 ✅ Patent 10,570,383 granted on 2020-02-25
US20190194634A1
Chemistry; metallurgy

Variants of fungal cellulase

#3023
US20190194635A1
Chemistry; metallurgy

Polypeptides Having Xylanase Activity and Polynucleotides Encoding Same

#3024
US20190194636A1
Chemistry; metallurgy

PROTEASE VARIANTS AND USES THEREOF

#3025 ✅ Patent 11,208,646 granted on 2021-12-28
US20190194637A1
Chemistry; metallurgy

Endolysin variant

#3026 ✅ Patent 10,683,493 granted on 2020-06-16
US20190194638A1
Chemistry; metallurgy

Fusion proteins comprising an aldolase enzyme joined to a maltose binding protein

#3027 ✅ Patent 10,662,417 granted on 2020-05-26
US20190194639A1
Chemistry; metallurgy

Pectate lyase variants and polynucleotides encoding same

#3028
US20190194640A9
Chemistry; metallurgy

REVERSE TRANSCRIPTASE MIXTURES WITH IMPROVED STORAGE STABILITY

#3029 ✅ Patent 11,396,649 granted on 2022-07-26
US20190194641A1
Chemistry; metallurgy

Site-specific conjugation to antibody lysine residues with solid-phase immobilized microbial transglutaminase MTG and MTG in solution

#3030 ✅ Patent 11,603,527 granted on 2023-03-14
US20190194642A1
Chemistry; metallurgy

Method and kit for viral vector isolation

#3031 ✅ Patent 10,752,648 granted on 2020-08-25
US20190194643A1
Chemistry; metallurgy

Magnetic ionic liquids, methods of making and uses thereof as solvents in the extraction and preservation of nucleic acids

#3032 ✅ Patent 10,934,330 granted on 2021-03-02
US20190194644A1
Chemistry; metallurgy

Methods for modulating the activity of insecticidal proteins

#3033 ✅ Patent 11,299,727 granted on 2022-04-12
US20190194645A1
Chemistry; metallurgy

System for analyzing single cell

#3034
US20190194646A1
Chemistry; metallurgy

RAPID AND SIMPLIFIED DEVELOPING ANTIBODIES AND FABs OR OTHER MOLECULES CONSISTING OF AMINO ACIDS RECOGNIZING NATURAL ANTIGENS OR NON-NATURAL MOLECULAR TARGETS USING SPECIAL BLOCKING AGENT

#3035 ✅ Patent 10,544,411 granted on 2020-01-28
US20190194647A1
Chemistry; metallurgy

Methods for generating a glucose permease library and uses thereof

#3036
US20190194648A1
Chemistry; metallurgy

CONSTRUCTION METHOD FOR SERIAL SEQUENCING LIBRARIES OF RAD TAGS

#3037 ✅ Patent 11,198,865 granted on 2021-12-14
US20190194649A1
Chemistry; metallurgy

Splinted ligation adapter tagging

#3038 ✅ Patent 11,584,928 granted on 2023-02-21
US20190194650A1
Chemistry; metallurgy

Methods for generating barcoded combinatorial libraries

#3039 ✅ Patent 11,155,813 granted on 2021-10-26
US20190194651A1
Chemistry; metallurgy

Semi-random barcodes for nucleic acid analysis

#3040
US20190194652A1
Chemistry; metallurgy

HIV CLINICAL PLAN

#3041 ✅ Patent 11,485,971 granted on 2022-11-01
US20190194653A1
Chemistry; metallurgy

CRISP-seq, an integrated method for massively parallel single cell RNA-seq and CRISPR pooled screens

#3042
US20190194654A1
Chemistry; metallurgy

COMBINATION

#3043
US20190194655A1
Chemistry; metallurgy

POLYNUCLEOTIDE CONSTRUCTS HAVING AN AUXILIARY MOIETY NON-BIOREVERSIBLY LINKED TO AN INTERNUCLEOSIDE PHOSPHATE OR PHOSPHOROTHIOATE

#3044 ✅ Patent 10,913,946 granted on 2021-02-09
US20190194656A1
Chemistry; metallurgy

RNA modulating oligonucleotides with improved characteristics for the treatment of Duchenne and Becker muscular dystrophy

#3045 ✅ Patent 10,472,632 granted on 2019-11-12
US20190194657A1
Chemistry; metallurgy

Anti-connexin compounds targeted to connexins and methods of use thereof

#3046
US20190194658A1
Chemistry; metallurgy

RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)

#3047
US20190194659A1
Chemistry; metallurgy

ANTISENSE POLYNUCLEOTIDES TO INDUCE EXON SKIPPING AND METHOD OF TREATING DYSTROPHIES

#3048 ✅ Patent 10,801,027 granted on 2020-10-13
US20190194660A1
Chemistry; metallurgy

Inhibitors of SRSF1 to treat neurodegenerative disorders

#3049 ✅ Patent 10,696,967 granted on 2020-06-30
US20190194661A1
Chemistry; metallurgy

Natural cryptic exon removal by pairs of antisense oligonucleotides

#3050
US20190194662A1
Chemistry; metallurgy

MIR-92 INHIBITORS AND USES THEREOF

#3051 ✅ Patent 11,008,573 granted on 2021-05-18
US20190194663A1
Chemistry; metallurgy

MicroRNA-198 as a tumor suppressor in ovarian cancer

#3052 ✅ Patent 11,203,757 granted on 2021-12-21
US20190194664A1
Chemistry; metallurgy

Use of Rad18 inhibitors in the treatment of tumors

#3053 ✅ Patent 10,465,195 granted on 2019-11-05
US20190194665A1
Chemistry; metallurgy

Methods and compositions for the specific inhibition of glycolate oxidase (HAO1) by double-stranded RNA

#3054 ✅ Patent 11,236,339 granted on 2022-02-01
US20190194666A1
Chemistry; metallurgy

Modulation of GYS1 expression

#3055 ✅ Patent 10,870,857 granted on 2020-12-22
US20190194667A1
Chemistry; metallurgy

Method of producing ginsenosides 20(S)-Rg3 and 20(S)-Rh2 using ginsenoside glycosidases

#3056 ✅ Patent 10,626,402 granted on 2020-04-21
US20190194668A1
Chemistry; metallurgy

Nuclease-mediated DNA assembly

#3057 ✅ Patent 11,136,585 granted on 2021-10-05
US20190194669A1
Chemistry; metallurgy

UTRs increasing the translation efficiency of RNA molecules

#3058 ✅ Patent 11,702,663 granted on 2023-07-18
US20190194670A1
Chemistry; metallurgy

Bacteria-based protein delivery

#3059
US20190194671A1
Chemistry; metallurgy

Erythritol production in cyanobacteria

#3060 ✅ Patent 11,174,493 granted on 2021-11-16
US20190194672A1
Chemistry; metallurgy

Seedless fruit producing plants

#3061 ✅ Patent 11,225,668 granted on 2022-01-18
US20190194673A1
Chemistry; metallurgy

Modified FRT recombination site libraries and methods of use

#3062 ✅ Patent 11,098,317 granted on 2021-08-24
US20190194674A1
Chemistry; metallurgy

Optimal maize loci

#3063 ✅ Patent 10,941,408 granted on 2021-03-09
US20190194675A1
Chemistry; metallurgy

System, method, and device for the expression or repression of proteins

#3064 ✅ Patent 12,065,653 granted on 2024-08-20
US20190194676A1
Chemistry; metallurgy

Plant regulatory elements and methods of use thereof

#3065
US20190194677A1
Chemistry; metallurgy

TRANSGENIC PLANTS AND A TRANSIENT TRANSFORMATION SYSTEM FOR GENOME-WIDE TRANSCRIPTION FACTOR TARGET DISCOVERY

#3066 ✅ Patent 10,954,524 granted on 2021-03-23
US20190194678A1
Chemistry; metallurgy

AP2 domain transcription factor ODP2 (ovule development protein 2) and methods of use

#3067 ✅ Patent 11,332,754 granted on 2022-05-17
US20190194679A1
Chemistry; metallurgy

Codon optimization for increasing transgene expression in chloroplasts of higher seed plants

#3068
US20190194680A1
Chemistry; metallurgy

GEMINIVIRAL VECTOR FOR EXPRESSION OF RITUXIMAB

#3069 ✅ Patent 11,162,109 granted on 2021-11-02
US20190194681A1
Chemistry; metallurgy

Methods and compositions for expression of transgenes in plants

#3070
US20190194682A1
Chemistry; metallurgy

YIELD IMPROVEMENT IN PLANTS

#3071
US20190194683A1
Chemistry; metallurgy

METHODS AND COMPOSITIONS FOR RESISTANCE TO CYST NEMATODE IN PLANTS

#3072
US20190194684A1
Chemistry; metallurgy

PARTHENOCARPY REGULATION GENE AND USE THEREOF

#3073 ✅ Patent 11,473,103 granted on 2022-10-18
US20190194685A1
Chemistry; metallurgy

Nucleus-encoded male sterility through mutation in cytochrome P450 oxidase

#3074
US20190194686A1
Chemistry; metallurgy

HOST CELLS WITH ENHANCED PROTEIN EXPRESSION EFFICIENCY AND USES THEREOF

#3075
US20190194687A1
Chemistry; metallurgy

EFFICIENT NON-MEIOTIC ALLELE INTROGRESSION IN LIVESTOCK

#3076
US20190194688A1
Chemistry; metallurgy

CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF

#3077
US20190194689A1
Chemistry; metallurgy

CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF

#3078 ✅ Patent 12,049,513 granted on 2024-07-30
US20190194690A1
Chemistry; metallurgy

Oncolytic group B adenovirus expressing a stroma-targeted bispecific t-cell engager

#3079 ✅ Patent 11,827,899 granted on 2023-11-28
US20190194691A1
Chemistry; metallurgy

Vector-free delivery of gene editing proteins and compositions to cells and tissues

#3080 ✅ Patent 11,396,665 granted on 2022-07-26
US20190194692A1
Chemistry; metallurgy

CRISPR-CAS system for a filamentous fungal host cell

#3081 ✅ Patent 10,465,207 granted on 2019-11-05
US20190194693A1
Chemistry; metallurgy

CRISPR enabled multiplexed genome engineering

#3082 ✅ Patent 11,739,351 granted on 2023-08-29
US20190194694A1
Chemistry; metallurgy

Eukaryotic cells for protein manufacturing and methods of making them

#3083 ✅ Patent 10,844,405 granted on 2020-11-24
US20190194695A1
Chemistry; metallurgy

Enzymes and microorganisms for the production of 1,3-butadiene and other dienes

#3084 ✅ Patent 11,028,414 granted on 2021-06-08
US20190194696A1
Chemistry; metallurgy

Inositol preparation method

#3085 ✅ Patent 10,655,149 granted on 2020-05-19
US20190194697A1
Chemistry; metallurgy

Pretreatment of lignocellulosic biomass with sulfur dioxide and/or sulfurous acid

#3086 ✅ Patent 11,932,896 granted on 2024-03-19
US20190194698A1
Chemistry; metallurgy

Host cells and methods for producing hydroxytyrosol

#3087 ✅ Patent 11,124,809 granted on 2021-09-21
US20190194699A1
Chemistry; metallurgy

Production of alpha-(R)-(E)-(+)-ionone in recombinant

#3088
US20190194700A1
Chemistry; metallurgy

Mutant Filamentous Fungus and Method for Producing C4 Dicarboxylic Acid Using Same

#3089
US20190194701A1
Chemistry; metallurgy

METHOD FOR PRODUCING BUTYRIC ACID AND/OR ITS SALTS

#3090 ✅ Patent 10,745,724 granted on 2020-08-18
US20190194702A1
Chemistry; metallurgy

Anaplerotic oil production in microbials

#3091
US20190194703A1
Chemistry; metallurgy

ACYL-ACP THIOESTERASES AND MUTANTS THEREOF

#3092 ✅ Patent 10,774,350 granted on 2020-09-15
US20190194704A1
Chemistry; metallurgy

Method for fermentative production of oxidized coenzyme Q10

#3093 ✅ Patent 10,612,055 granted on 2020-04-07
US20190194705A1
Chemistry; metallurgy

Control of biofilm dispersal for the production of amino acids or amino acid-derived products

#3094
US20190194706A1
Chemistry; metallurgy

Biosynthesis of Oxidised 13R-MO and Related Compounds

#3095 ✅ Patent 10,988,786 granted on 2021-04-27
US20190194707A1
Chemistry; metallurgy

Mutant 4-hydroxyphenylacetate 3-hydroxylases and uses thereof

#3096 ✅ Patent 11,041,179 granted on 2021-06-22
US20190194708A1
Chemistry; metallurgy

Method for preparing branched cyclodextrin and application thereof

#3097 ✅ Patent 11,447,807 granted on 2022-09-20
US20190194709A1
Chemistry; metallurgy

Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing

#3098
US20190194710A1
Chemistry; metallurgy

Method for Producing Recombinant Protein

#3099 ✅ Patent 11,008,601 granted on 2021-05-18
US20190194711A1
Chemistry; metallurgy

Endo-S2 mutants as glycosynthases, method of making and use for glycoengineering of glycoproteins

#3100 ✅ Patent 10,731,196 granted on 2020-08-04
US20190194712A1
Chemistry; metallurgy

Methods for producing ribosomally synthesized and posttranslationally modified peptides

#3101 ✅ Patent 11,492,650 granted on 2022-11-08
US20190194713A1
Chemistry; metallurgy

Production of seleno-biologics in genomically recoded organisms

#3102 ✅ Patent 11,136,612 granted on 2021-10-05
US20190194714A1
Chemistry; metallurgy

Reagent for glucose sensor, glucose sensor, method for manufacturing glucose sensor, and glucose measuring device

#3103 ✅ Patent 11,261,475 granted on 2022-03-01
US20190194715A1
Chemistry; metallurgy

Nano-neurotoxicity bio-marker composition based on intracellular aggregates which are biomarkers of degenerative brain diseases

#3104 ✅ Patent 11,352,654 granted on 2022-06-07
US20190194716A1
Chemistry; metallurgy

Composition and methods for processing a sputum sample

#3105 ✅ Patent 11,008,603 granted on 2021-05-18
US20190194717A1
Chemistry; metallurgy

Method and kit for detecting pathogenic microorganism

#3106
US20190194718A1
Chemistry; metallurgy

GENERATION OF TAGGED DNA FRAGMENTS

#3107 ✅ Patent 11,293,056 granted on 2022-04-05
US20190194719A1
Chemistry; metallurgy

Methods and compositions for manipulating nucleic acids

#3108
US20190194720A1
Chemistry; metallurgy

Systems and Methods for Whole Genome Amplification

#3109 ✅ Patent 10,961,571 granted on 2021-03-30
US20190194721A1
Chemistry; metallurgy

Polymerase assay with a FRET substrate

#3110 ✅ Patent 11,649,480 granted on 2023-05-16
US20190194722A1
Chemistry; metallurgy

Method for modifying a template double stranded polynucleotide

#3111 ✅ Patent 11,884,972 granted on 2024-01-30
US20190194723A1
Chemistry; metallurgy

Method to screen for a mutant within a population of organisms by applying a pooling and splitting approach

#3112 ✅ Patent 11,208,681 granted on 2021-12-28
US20190194724A1
Chemistry; metallurgy

High throughput oil-emulsion synthesis of bowtie barcodes for paired mRNA capture and sequencing from individual cells

#3113 ✅ Patent 11,840,742 granted on 2023-12-12
US20190194725A1
Chemistry; metallurgy

Method for detecting active tuberculosis

#3114 ✅ Patent 11,827,944 granted on 2023-11-28
US20190194726A1
Chemistry; metallurgy

Antibiotic susceptibility of microorganisms and related compositions, methods and systems

#3115
US20190194727A1
Chemistry; metallurgy

MULTITAG SEQUENCING ECOGENOMICS ANALYSIS

#3116
US20190194728A1
Chemistry; metallurgy

Systemic inflammatory and pathogen biomarkers and uses therefor

#3117
US20190194729A1
Chemistry; metallurgy

RECOGNITION SEQUENCES FOR I-CREI-DERIVED MEGANUCLEASES AND USES THEREOF

#3118 ✅ Patent 10,982,262 granted on 2021-04-20
US20190194730A1
Chemistry; metallurgy

Quencher and use thereof

#3119 ✅ Patent 11,519,021 granted on 2022-12-06
US20190194731A1
Chemistry; metallurgy

Methods of identifying microsatellite instability

#3120
US20190194732A1
Chemistry; metallurgy

DEVICE AND METHOD FOR NUCLEIC ACID MANIPULATION

#3121 ✅ Patent 11,000,059 granted on 2021-05-11
US20190194733A1
Chemistry; metallurgy

Nicotiana nucleic acid molecules and uses thereof

#3122 ✅ Patent 11,104,939 granted on 2021-08-31
US20190194734A1
Chemistry; metallurgy

High resolution systems, kits, apparatus, and methods for high throughput microbiology applications

#3123 ✅ Patent 11,104,940 granted on 2021-08-31
US20190194735A1
Chemistry; metallurgy

High resolution systems, kits, apparatus, and methods for high throughput microbiology applications

#3124 ✅ Patent 11,136,621 granted on 2021-10-05
US20190194736A1
Chemistry; metallurgy

High resolution systems, kits, apparatus, and methods for high throughput microbiology applications

#3125 ✅ Patent 11,535,889 granted on 2022-12-27
US20190194737A1
Chemistry; metallurgy

Use of transposase and Y adapters to fragment and tag DNA

#3126 ✅ Patent 11,845,982 granted on 2023-12-19
US20190194738A1
Chemistry; metallurgy

Key-value store that harnesses live micro-organisms to store and retrieve digital information

#3127 ✅ Patent 11,174,512 granted on 2021-11-16
US20190194739A1
Chemistry; metallurgy

Homopolymer encoded nucleic acid memory

#3128 ✅ Patent 11,373,730 granted on 2022-06-28
US20190194740A1
Chemistry; metallurgy

Determination of microorganism operational taxonomic unit and sequence-assisted separation

#3129 ✅ Patent 10,612,087 granted on 2020-04-07
US20190194741A1
Chemistry; metallurgy

Sequencing reactions with monovalent cations for pulse width control

#3130 ✅ Patent 11,485,999 granted on 2022-11-01
US20190194742A1
Chemistry; metallurgy

Metagenomics for microbiomes

#3131 ✅ Patent 10,774,380 granted on 2020-09-15
US20190194743A1
Chemistry; metallurgy

Methods for multiplex PCR amplification of target loci in a nucleic acid sample

#3132 ✅ Patent 11,319,587 granted on 2022-05-03
US20190194744A1
Chemistry; metallurgy

Immobilized buffer particles and uses thereof

#3133 ✅ Patent 10,538,808 granted on 2020-01-21
US20190194745A1
Chemistry; metallurgy

Photoactive compounds and methods for biomolecule detection and sequencing

#3134
US20190194746A1
Chemistry; metallurgy

NUCLEIC ACID OLIGOMER FOR RNA HYBRID FORMATION

#3135 ✅ Patent 11,634,770 granted on 2023-04-25
US20190194747A1
Chemistry; metallurgy

Nicking and extension amplification reaction (NEAR) of respiratory syncytial virus species

#3136 ✅ Patent 10,731,214 granted on 2020-08-04
US20190194748A1
Chemistry; metallurgy

Nucleic acid probe and method of detecting genomic fragments

#3137
US20190194749A1
Chemistry; metallurgy

METHOD FOR OBTAINING USEFUL DATA FOR THE DIFFERENTIAL DIAGNOSIS OF LIVER FIBROSIS

#3138
US20190194750A1
Chemistry; metallurgy

BIOMARKERS OF RESPONSE TO SELECTIVE INHIBITORS OF AURORA A KINASE

#3139 ✅ Patent 10,837,061 granted on 2020-11-17
US20190194751A1
Chemistry; metallurgy

Enrichment and detection of nucleic acids with ultra-high sensitivity

#3140 ✅ Patent 10,837,062 granted on 2020-11-17
US20190194752A1
Chemistry; metallurgy

Method for predicting a treatment response to a CRHR1 antagonist and/or a Vantagonist in a patient with depressive and/or anxiety symptoms

#3141 ✅ Patent 11,339,439 granted on 2022-05-24
US20190194753A1
Chemistry; metallurgy

Methods and compositions for screening and treating developmental disorders

#3142 ✅ Patent 11,549,146 granted on 2023-01-10
US20190194754A1
Chemistry; metallurgy

Diagnosis of inflammatory bowel disease based on genes

#3143 ✅ Patent 10,633,706 granted on 2020-04-28
US20190194755A1
Chemistry; metallurgy

Analysis of methylation status and copy number

#3144
US20190194756A1
Chemistry; metallurgy

GENE PANEL SPECIFIC FOR PULMONARY HYPERTENSION AND ITS USES

#3145
US20190194757A1
Chemistry; metallurgy

Means and methods for identifying a patient having a BRAF-positive cancer as a non-responder to a BRAF inhibitor as a responder to an MAPK/ERK inhibitor

#3146 ✅ Patent 11,319,596 granted on 2022-05-03
US20190194758A1
Chemistry; metallurgy

Detecting mutations and ploidy in chromosomal segments

#3147 ✅ Patent 11,408,037 granted on 2022-08-09
US20190194759A1
Chemistry; metallurgy

Detecting mutations and ploidy in chromosomal segments

#3148
US20190194760A1
Chemistry; metallurgy

NOVEL BIOMARKERS

#3149 ✅ Patent 10,815,534 granted on 2020-10-27
US20190194761A1
Chemistry; metallurgy

Methods and materials for treating estrogen receptor positive breast cancer

#3150 ✅ Patent 10,563,268 granted on 2020-02-18
US20190194762A1
Chemistry; metallurgy

Long non-coding RNA and use thereof in detection of intramuscular fat in pigs

#3151 ✅ Patent 10,900,094 granted on 2021-01-26
US20190194763A1
Chemistry; metallurgy

Methods of identifying and modulating pathogen resistance in plants

#3152
US20190194764A1
Chemistry; metallurgy

REPORTER OF GENOMIC METHYLATION AND USES THEREOF

#3153
US20190194765A1
Chemistry; metallurgy

SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES

#3154 ✅ Patent 12,209,292 granted on 2025-01-28
US20190194766A1
Chemistry; metallurgy

Nucleic acid amplification assays for detection of pathogens

#3155 ✅ Patent 11,035,011 granted on 2021-06-15
US20190194767A1
Chemistry; metallurgy

Detection of DNA sequences as risk factors for HIV infection

#3156 ✅ Patent 11,191,775 granted on 2021-12-07
US20190194768A1
Chemistry; metallurgy

PAPD5 and PAPD7 inhibitors for treating a hepatitis B infection

#3157 ✅ Patent 11,549,096 granted on 2023-01-10
US20190194769A1
Chemistry; metallurgy

Genetic perturbation of the RNA degradosome protein complex

#3158 ✅ Patent 11,519,046 granted on 2022-12-06
US20190194770A1
Chemistry; metallurgy

Cold-rolled high-strength steel plate having excellent phosphating performance and formability and manufacturing method therefor

#3159 ✅ Patent 11,085,097 granted on 2021-08-10
US20190194771A1
Chemistry; metallurgy

Self-lubricating rolling bearing and preparation method therefor

#3160 ✅ Patent 11,220,724 granted on 2022-01-11
US20190194772A1
Chemistry; metallurgy

980 MPa-grade hot-rolled ferritic bainite dual-phase steel and manufacturing method therefor

#3161 ✅ Patent 11,186,890 granted on 2021-11-30
US20190194773A1
Chemistry; metallurgy

Two-phase steel and method for the fabrication of the same

#3162 ✅ Patent 11,505,844 granted on 2022-11-22
US20190194774A1
Chemistry; metallurgy

Cold-rolled high-strength steel plate having excellent phosphating performance and formability and manufacturing method therefor

#3163 ✅ Patent 10,982,297 granted on 2021-04-20
US20190194775A1
Chemistry; metallurgy

Steel sheet and method for producing the same

#3164
US20190194776A1
Chemistry; metallurgy

WELDING JOINT HAVING EXCELLENT FATIGUE CHARACTERISTICS AND METHOD FOR MANUFACTURING SAME

#3165 ✅ Patent 10,619,225 granted on 2020-04-14
US20190194777A1
Chemistry; metallurgy

Detoxification treatment method for extracting and recycling chromium from hexavalent chromium-containing residues

#3166 ✅ Patent 11,041,229 granted on 2021-06-22
US20190194778A1
Chemistry; metallurgy

Silver-coated alloy powder, electrically conductive paste, electronic part, and electric device

#3167
US20190194779A1
Chemistry; metallurgy

ALUMINIUM ALLOY AND ALUMINIUM ALLOY STRIP FOR PEDESTRIAN IMPACT PROTECTION

#3168
US20190194780A1
Chemistry; metallurgy

ALUMINUM ALLOY ARTICLES HAVING IMPROVED BOND DURABILITY AND INERT SURFACE ALUMINUM ALLOY ARTICLES AND METHODS OF MAKING AND USING THE SAME

#3169
US20190194781A1
Chemistry; metallurgy

ALUMINUM ALLOY POWDER FOR ADDITIVE MANUFACTURING, AND METHOD FOR MANUFACTURING A PIECE BY MANUFACTURING FROM THIS POWDER

#3170 ✅ Patent 11,053,572 granted on 2021-07-06
US20190194782A1
Chemistry; metallurgy

Biodegradable magnesium alloys, methods of manufacture thereof and articles comprising the same

#3171 ✅ Patent 10,920,304 granted on 2021-02-16
US20190194783A1
Chemistry; metallurgy

Cemented carbide and its production method, and rolling roll

#3172
US20190194784A1
Chemistry; metallurgy

Aqueous Solution Composition and Method for Manufacturing the Same, Oxide Powder and Method for Manufacturing the Same, Carbide Powder and Method for Manufacturing the Same, and Cemented Carbide and Method for Manufacturing the Same

#3173 ✅ Patent 11,242,582 granted on 2022-02-08
US20190194785A1
Chemistry; metallurgy

Method of making components with metal matrix composites and components made therefrom

#3174
US20190194786A1
Chemistry; metallurgy

Hardfacing Material

#3175
US20190194787A1
Chemistry; metallurgy

Austenitic Stainless Steel

#3176
US20190194788A1
Chemistry; metallurgy

METHOD OF PRE-AGING NITIHF SHAPE MEMORY ALLOYS AND PARTS THEREFROM WITH UNIFORM MICROSTRUCTURES AND SUPERIOR PROPERTIES

#3177
US20190194789A1
Chemistry; metallurgy

Nickel-Based Alloy Regenerated Member and Method for Manufacturing Same

#3178 ✅ Patent 11,142,816 granted on 2021-10-12
US20190194790A1
Chemistry; metallurgy

Roll for use in a hot dip coating line

#3179 ✅ Patent 11,255,009 granted on 2022-02-22
US20190194791A1
Chemistry; metallurgy

Method and coating device for coating a metal strip

#3180 ✅ Patent 10,982,309 granted on 2021-04-20
US20190194792A1
Chemistry; metallurgy

Hot-rolled galvanized steel sheet having excellent galling resistance, formability and sealer-adhesion property and method for manufacturing same

#3181 ✅ Patent 11,162,167 granted on 2021-11-02
US20190194793A1
Chemistry; metallurgy

Nitriding process for carburizing Ferrium steels

#3182
US20190194794A1
Chemistry; metallurgy

CERAMIC COLORING METHOD AND A CERAMIC PIECE FOR ELECTRONIC PRODUCTS

#3183
US20190194795A1
Chemistry; metallurgy

SLIDING ELEMENT WITH MAX PHASE COATING

#3184 ✅ Patent 10,865,469 granted on 2020-12-15
US20190194796A1
Chemistry; metallurgy

Compound semiconductor, method for manufacturing same, and nitride semiconductor

#3185 ✅ Patent 10,900,115 granted on 2021-01-26
US20190194797A1
Chemistry; metallurgy

Chalcogenide film including a noble metal chalcogenide material, device including the chalcogenide film, and method of forming the chalcogenide film

#3186 ✅ Patent 10,844,474 granted on 2020-11-24
US20190194798A1
Chemistry; metallurgy

Cathode unit for sputtering apparatus

#3187
US20190194799A1
Chemistry; metallurgy

LINE-OF-SIGHT COATING FIXTURE AND APPARATUS

#3188 ✅ Patent 11,473,185 granted on 2022-10-18
US20190194800A1
Chemistry; metallurgy

Method for the protection of a hafnium-free, nickel-based monocrystalline superalloy part against corrosion and oxidation

#3189 ✅ Patent 10,526,696 granted on 2020-01-07
US20190194801A1
Chemistry; metallurgy

Multi-electrode molecular sensing devices and methods of making the same

#3190 ✅ Patent 11,371,141 granted on 2022-06-28
US20190194802A1
Chemistry; metallurgy

Plasma process apparatus with low particle contamination and method of operating the same

#3191
US20190194803A1
Chemistry; metallurgy

SUSCEPTOR CLEANING METHOD

#3192 ✅ Patent 10,801,107 granted on 2020-10-13
US20190194804A1
Chemistry; metallurgy

Apparatus for collecting by-product in semiconductor process

#3193 ✅ Patent 10,590,530 granted on 2020-03-17
US20190194805A1
Chemistry; metallurgy

Gas control in process chamber

#3194 ✅ Patent 11,236,021 granted on 2022-02-01
US20190194806A1
Chemistry; metallurgy

Mitigating pyrophoric deposits in exhaust piping during SIC CVI/CVD processes by introducing water vapor into an outlet portion of a reaction chamber

#3195 ✅ Patent 10,961,623 granted on 2021-03-30
US20190194807A1
Chemistry; metallurgy

Film forming method

#3196 ✅ Patent 10,487,400 granted on 2019-11-26
US20190194808A1
Chemistry; metallurgy

Method of decreasing visible flickering effects in a light emitting diode array operated by pulse width modulated signals

#3197
US20190194809A1
Chemistry; metallurgy

APPARATUS AND METHODS FOR ATOMIC LAYER DEPOSITION

#3198 ✅ Patent 10,626,500 granted on 2020-04-21
US20190194810A1
Chemistry; metallurgy

Showerhead design

#3199 ✅ Patent 11,214,869 granted on 2022-01-04
US20190194811A1
Chemistry; metallurgy

Heat treatment apparatus for high-quality graphene synthesis

#3200
US20190194812A1
Chemistry; metallurgy

GAP-FILLING SEALING LAYER OF THERMAL BARRIER COATING

#3201 ✅ Patent 10,947,627 granted on 2021-03-16
US20190194813A1
Chemistry; metallurgy

Water electrolysis apparatus

#3202
US20190194814A1
Chemistry; metallurgy

ELECTROCHEMICAL METHOD FOR MANUFACTURING METHYL ETHYL KETONE

#3203 ✅ Patent 10,544,513 granted on 2020-01-28
US20190194815A1
Chemistry; metallurgy

Electrochemical reaction device

#3204 ✅ Patent 11,053,599 granted on 2021-07-06
US20190194816A1
Chemistry; metallurgy

Process for starting mode or stand-by mode operation of a power-to-gas unit comprising a plurality of high-temperature electrolysis (SOEC) or co-electrolysis reactors

#3205
US20190194817A1
Chemistry; metallurgy

HIGH PURITY METALLIC TOP COAT FOR SEMICONDUCTOR MANUFACTURING COMPONENTS

#3206
US20190194818A1
Chemistry; metallurgy

METHOD OF PRODUCING SILICON CARBIDE SINGLE CRYSTAL

#3207 ✅ Patent 10,907,272 granted on 2021-02-02
US20190194819A1
Chemistry; metallurgy

Method of manufacturing silicon carbide single crystal ingot

#3208 ✅ Patent 11,168,410 granted on 2021-11-09
US20190194820A1
Chemistry; metallurgy

Susceptor for a chemical vapour deposition reactor

#3209 ✅ Patent 11,124,893 granted on 2021-09-21
US20190194821A1
Chemistry; metallurgy

Method of treating a single crystal silicon ingot to improve the LLS ring/core pattern

#3210 ✅ Patent 11,459,669 granted on 2022-10-04
US20190194822A1
Chemistry; metallurgy

SiC ingot and method of manufacturing SiC ingot

#3211 ✅ Patent 10,837,123 granted on 2020-11-17
US20190194823A1
Chemistry; metallurgy

Method of manufacturing SiC ingot

#3212 ✅ Patent 10,844,517 granted on 2020-11-24
US20190194824A1
Chemistry; metallurgy

Method of processing SiC single crystal and method of manufacturing SiC ingot

#3213 ✅ Patent 11,078,600 granted on 2021-08-03
US20190194825A1
Textiles; paper

Method and apparatus for fabricating a fibre array and structure incorporating a fibre array

#3214 ✅ Patent 11,788,208 granted on 2023-10-17
US20190194826A1
Textiles; paper

Continuous-filament spunbond

#3215
US20190194827A1
Textiles; paper

HYBRID YARNS FORMED WITH FIBERS HAVING ROUNDED TIPS AND METHOD OF MAKING THE SAME

#3216 ✅ Patent 11,104,581 granted on 2021-08-31
US20190194828A1
Textiles; paper

Methods for producing carbon fibers from coal

#3217
US20190194829A1
Textiles; paper

COAGULATED YARN AND MANUFACTURING METHOD THEREOF, CARBON FIBER PRECURSOR FIBER, AND METHOD OF MANUFACTURING CARBON FIBER

#3218 ✅ Patent 11,053,611 granted on 2021-07-06
US20190194830A1
Textiles; paper

Oxidation furnace

#3219
US20190194831A1
Textiles; paper

MICRO CELLULOSE FIBER COMPLEX

#3220 ✅ Patent 10,718,070 granted on 2020-07-21
US20190194832A1
Textiles; paper

Process for increasing the enzymatic accessibility of a thermally treated ligno-cellulosic biomass feedstock

#3221
US20190194833A1
Textiles; paper

SYSTEMS AND METHODS FOR CONTROLLING CARBON TOW WIDTH

#3222
US20190194834A1
Textiles; paper

Drawing Frame for Drawing a Strand-Like Fiber Assembly and Textile Machine Equipped Therewith

#3223 ✅ Patent 11,198,956 granted on 2021-12-14
US20190194835A1
Textiles; paper

Multipoint textile machine

#3224
US20190194836A1
Textiles; paper

BUFFER METHOD AND SYSTEM FOR ALTERNATING TWIST PLIED YARN

#3225 ✅ Patent 11,008,677 granted on 2021-05-18
US20190194837A1
Textiles; paper

Woven sailcloth

#3226
US20190194838A1
Textiles; paper

UNIDIRECTIONAL SIGHT-TRANSMISSION FABRIC AND UNIDIRECTIONAL SIGHT-TRANSMISSION CURTAIN

#3227
US20190194839A1
Textiles; paper

A STRETCHABLE FABRIC AND A METHOD, A WRINKLE-FREE FABRIC AND GARMENTS THEREOF

#3228 ✅ Patent 11,028,506 granted on 2021-06-08
US20190194840A1
Textiles; paper

Active textile structures with selectively variable surface friction characteristics

#3229 ✅ Patent 11,834,763 granted on 2023-12-05
US20190194841A1
Textiles; paper

Terry products comprising plied yarns and associated methods for manufacture

#3230 ✅ Patent 11,332,857 granted on 2022-05-17
US20190194842A1
Textiles; paper

Circular knitting machine

#3231 ✅ Patent 10,982,358 granted on 2021-04-20
US20190194843A1
Textiles; paper

Multi-functional knitted textiles

#3232 ✅ Patent 10,626,531 granted on 2020-04-21
US20190194844A1
Textiles; paper

Multifilament and braid using same

#3233 ✅ Patent 11,180,875 granted on 2021-11-23
US20190194845A1
Textiles; paper

Tool and method for creating fashion accessories

#3234
US20190194846A1
Textiles; paper

METHOD FOR STRENGTHENING A NONWOVEN FABRIC

#3235
US20190194847A1
Textiles; paper

Solution-Spun Polyamide Nanofiber Nonwovens

#3236 ✅ Patent 10,900,159 granted on 2021-01-26
US20190194848A1
Textiles; paper

Batting bin

#3237 ✅ Patent 11,142,856 granted on 2021-10-12
US20190194849A1
Textiles; paper

Treatment unit for in-line treatment of thread

#3238
US20190194850A1
Textiles; paper

COMBINATION WASHER/DRYER APPARATUS

#3239
US20190194851A1
Textiles; paper

Method of having cleaner laundry

#3240 ✅ Patent 10,968,557 granted on 2021-04-06
US20190194852A1
Textiles; paper

Laundry treating apparatus

#3241 ✅ Patent 11,053,624 granted on 2021-07-06
US20190194853A1
Textiles; paper

Laundry treating appliance with drive attachment mechanism

#3242 ✅ Patent 11,248,327 granted on 2022-02-15
US20190194854A1
Textiles; paper

Counterweight of washing machine, washing machine, and counterweighting method for washing machine

#3243 ✅ Patent 11,396,723 granted on 2022-07-26
US20190194855A1
Textiles; paper

Washing machine and control method of the same

#3244
US20190194856A1
Textiles; paper

LAUNDRY SERVICE SYSTEM FOR SCHEDULING AND PAYMENT

#3245 ✅ Patent 10,822,736 granted on 2020-11-03
US20190194857A1
Textiles; paper

Household appliance with a touch display

#3246 ✅ Patent 11,105,033 granted on 2021-08-31
US20190194858A1
Textiles; paper

Integrated single dose and bulk dispenser for a laundry treating appliance

#3247
US20190194859A1
Textiles; paper

LAUNDRY TREATMENT APPARATUS AND CONTROL METHOD THEREOF

#3248
US20190194860A1
Textiles; paper

WASHING AND DRYING INTEGRATED MACHINE AND CONTROL METHOD

#3249 ✅ Patent 11,193,226 granted on 2021-12-07
US20190194861A1
Textiles; paper

Laundry treatment apparatus and control method thereof

#3250
US20190194862A1
Textiles; paper

Method for having cleaner dried laundry

#3251 ✅ Patent 10,711,392 granted on 2020-07-14
US20190194863A1
Textiles; paper

Pad-steam bleaching method for fabric based on TBLC-activated hydrogen peroxide system

#3252 ✅ Patent 10,526,748 granted on 2020-01-07
US20190194864A1
Textiles; paper

Method of providing moisture by atomization in ozonation of textile products

#3253 ✅ Patent 11,634,860 granted on 2023-04-25
US20190194865A1
Textiles; paper

Articles and methods for dispensing metal ions into laundry systems

#3254
US20190194866A1
Textiles; paper

METHOD FOR PRODUCING CELLULOSE FINE FIBER

#3255
US20190194867A1
Textiles; paper

DOUBLE ALKALI CHARGING FOR CHIP IMPREGNATION

#3256 ✅ Patent 11,072,888 granted on 2021-07-27
US20190194868A1
Textiles; paper

Fiber processing device and fibrous feedstock recycling device

#3257 ✅ Patent 11,072,889 granted on 2021-07-27
US20190194869A1
Textiles; paper

Clothing for a machine for producing a fibrous web and method for producing a clothing of this type

#3258 ✅ Patent 10,767,313 granted on 2020-09-08
US20190194870A1
Textiles; paper

Method for fabricating shaped paper products

#3259 ✅ Patent 10,787,769 granted on 2020-09-29
US20190194871A1
Textiles; paper

Fluorescent whitening agents and mixtures thereof

#3260 ✅ Patent 11,365,516 granted on 2022-06-21
US20190194872A1
Textiles; paper

Recyclable release substrate

#3261 ✅ Patent 10,697,124 granted on 2020-06-30
US20190194873A1
Textiles; paper

Sanitary tissue products

#3262 ✅ Patent 10,697,125 granted on 2020-06-30
US20190194874A1
Textiles; paper

Sanitary tissue products

#3263 ✅ Patent 10,704,202 granted on 2020-07-07
US20190194875A1
Textiles; paper

Sanitary tissue products

#3264 ✅ Patent 10,920,376 granted on 2021-02-16
US20190194876A1
Textiles; paper

Fibrous structures with shaped polymer particles

#3265 ✅ Patent 12,000,093 granted on 2024-06-04
US20190194877A1
Fixed constructions

Ballast sweeping installation for picking up and distributing ballast located on a track

#3266 ✅ Patent 11,268,247 granted on 2022-03-08
US20190194878A1
Fixed constructions

Adaptive railway fastener and anchor installation system

#3267 ✅ Patent 10,519,611 granted on 2019-12-31
US20190194879A1
Fixed constructions

Bearing pad

#3268 ✅ Patent 10,385,518 granted on 2019-08-20
US20190194880A1
Fixed constructions

Helically-packaged expansion joint seal system with coiling, tear strips or secondary packaging

#3269 ✅ Patent 10,465,344 granted on 2019-11-05
US20190194881A1
Fixed constructions

Covering device for a slotted channel

#3270 ✅ Patent 10,767,479 granted on 2020-09-08
US20190194882A1
Fixed constructions

Method and apparatus for removing pavement structures using plasma blasting

#3271 ✅ Patent 10,815,627 granted on 2020-10-27
US20190194883A1
Fixed constructions

Method for improving seismic performance of bridge by using beam body and energy dissipation and seismic mitigation bridge bearing

#3272 ✅ Patent 10,738,422 granted on 2020-08-11
US20190194884A1
Fixed constructions

Cable anchorage with seal element, prestressing system comprising such anchorage and method for installing and tensioning a sheathed elongated element

#3273 ✅ Patent 10,954,639 granted on 2021-03-23
US20190194885A1
Fixed constructions

One piece water permeable paver

#3274 ✅ Patent 10,801,170 granted on 2020-10-13
US20190194886A1
Fixed constructions

Magnetic marker and marker system

#3275
US20190194887A1
Fixed constructions

VEHICLE STOPPING APPARATUS

#3276
US20190194888A1
Fixed constructions

Vehicle Disablement System

#3277 ✅ Patent 11,608,604 granted on 2023-03-21
US20190194889A1
Fixed constructions

Single anchor terminal

#3278 ✅ Patent 10,550,533 granted on 2020-02-04
US20190194890A1
Fixed constructions

Bag and hand protector combination for sanitary waste or specimen collection

#3279
US20190194891A1
Fixed constructions

Wheeled Shovel

#3280 ✅ Patent 11,066,796 granted on 2021-07-20
US20190194892A1
Fixed constructions

Rotor for snow thrower

#3281 ✅ Patent 10,422,094 granted on 2019-09-24
US20190194893A1
Fixed constructions

Concrete block construction method and guide member for installing concrete block

#3282 ✅ Patent 10,612,204 granted on 2020-04-07
US20190194894A1
Fixed constructions

Sluice gate

#3283
US20190194895A1
Fixed constructions

METHODS AND APPARATUS FOR FORMING AN OFFSHORE WELL

#3284 ✅ Patent 10,619,322 granted on 2020-04-14
US20190194896A1
Fixed constructions

Dry-bulk tanker, conveying system for a dry-bulk tanker, as well as work train

#3285 ✅ Patent 10,760,237 granted on 2020-09-01
US20190194897A1
Fixed constructions

Method for optimizing processes for increasing the load-bearing capacity of foundation grounds

#3286 ✅ Patent 10,577,768 granted on 2020-03-03
US20190194898A1
Fixed constructions

Systems and methods for tethering subsea structure mounted on a wellhead

#3287 ✅ Patent 10,781,569 granted on 2020-09-22
US20190194899A1
Fixed constructions

Confinement structures—DefenCell plastic gabion system

#3288 ✅ Patent 10,914,048 granted on 2021-02-09
US20190194900A1
Fixed constructions

Height adjustable meter/device pit

#3289 ✅ Patent 10,597,843 granted on 2020-03-24
US20190194901A1
Fixed constructions

Utility loader with high lift loader arms and unifying hand grip for dual traction control levers

#3290 ✅ Patent 10,753,063 granted on 2020-08-25
US20190194902A1
Fixed constructions

Front loader

#3291 ✅ Patent 10,724,205 granted on 2020-07-28
US20190194903A1
Fixed constructions

Front loader and working machine

#3292 ✅ Patent 10,590,623 granted on 2020-03-17
US20190194904A1
Fixed constructions

Construction machine

#3293 ✅ Patent 11,085,169 granted on 2021-08-10
US20190194905A1
Fixed constructions

Work equipment control device and work machine

#3294 ✅ Patent 10,370,819 granted on 2019-08-06
US20190194906A1
Fixed constructions

Front loader and working vehicle with forwardly located coupling shaft

#3295 ✅ Patent 10,676,894 granted on 2020-06-09
US20190194907A1
Fixed constructions

Blade levelling apparatus with provision for mounted accessories

#3296 ✅ Patent 11,098,462 granted on 2021-08-24
US20190194908A1
Fixed constructions

Construction machine

#3297 ✅ Patent 10,851,521 granted on 2020-12-01
US20190194909A1
Fixed constructions

Construction machine

#3298 ✅ Patent 10,697,150 granted on 2020-06-30
US20190194910A1
Fixed constructions

Hydraulic drive system for electrically-driven hydraulic work machine

#3299 ✅ Patent 10,655,304 granted on 2020-05-19
US20190194911A1
Fixed constructions

System and method for estimating a payload of an industrial machine

#3300 ✅ Patent 11,268,264 granted on 2022-03-08
US20190194912A1
Fixed constructions

Control system for work vehicle, control method, and work vehicle