Roche Sequencing Solutions, Inc.

METHODS AND COMPOSITIONS FOR DNA LIBRARY PREPARATION AND ANALYSIS

#2 | 2026-02-26

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OSMOTIC IMBALANCE METHODS FOR BILAYER FORMATION

#3 | 2026-01-08

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LIBRARY PREPARATION AND ANALYTICAL METHODS FOR PRESERVING TOPOLOGICAL INFORMATION OF CELL-FREE DNA

#4 | 2025-12-18

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NON-DESTRUCTIVE BILAYER MONITORING USING MEASUREMENT OF BILAYER RESPONSE TO ELECTRICAL STIMULUS

#5 | 2025-11-13

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TAGGED NUCLEOSIDE COMPOUNDS USEFUL FOR NANOPORE DETECTION

#6 | 2025-10-02

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SINGLE MOLECULE NUCLEIC ACID DETECTION BY MISMATCH CLEAVAGE

#7 | 2025-07-24

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SYNTHESIS OF ISOMERICALLY PURE POLYOL-BASED PHOSPHORAMIDITES

#8 | 2025-05-08

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ELECTRICAL ENHANCEMENT OF BILAYER FORMATION

#9 | 2025-05-08

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REMOVING AND REINSERTING PROTEIN NANOPORES IN A MEMBRANE USING OSMOTIC IMBALANCE

#10 | 2025-04-17

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SYSTEMS FOR FORMING A NANOPORE IN A LIPID BILAYER

#11 | 2025-04-17 ✅ Patent 12,392,767 granted on 2025-08-19

US20250123261A1

NANOPORE ARRAYS

#12 | 2025-01-30

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LONG LIFETIME ALPHA-HEMOLYSIN NANOPORES

#13 | 2025-01-23

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METHODS FOR CREATING BILAYERS FOR USE WITH NANOPORE SENSORS

#14 | 2025-01-23

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NANOPORE BASED MOLECULAR DETECTION AND SEQUENCING

#15 | 2025-01-16

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METHOD FOR INLINE BILAYER CAPACITANCE MONITORING

#16 | 2025-01-09

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SYSTEMS AND METHODS FOR SELF-LIMITING PROTEIN PORE INSERTION IN A MEMBRANE

#17 | 2025-01-09

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NUCLEIC ACID SEQUENCING BY SYNTHESIS USING MAGNETIC SENSOR ARRAYS

#18 | 2024-12-19 ✅ Patent 12,173,353 granted on 2024-12-24

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Composition comprising cell origination barcodes for the analysis of both genomic DNA and CDNA from the same cell

#19 | 2024-12-12

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ALPHA-HEMOLYSIN VARIANTS WITH ALTERED CHARACTERISTICS

#20 | 2024-11-14 ✅ Patent 12,372,511 granted on 2025-07-29

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OSMOTIC IMBALANCE METHODS FOR BILAYER FORMATION

#21 | 2024-11-07 ✅ Patent 12,129,513 granted on 2024-10-29

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METHOD FOR BARCODING

#22 | 2024-09-26 ✅ Patent 12,129,512 granted on 2024-10-29

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Composition comprising cell origination barcodes for the analysis of both protein and nucleic acid from the same cell

#23 | 2024-09-26 ✅ Patent 12,435,114 granted on 2025-10-07

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OMPG VARIANTS

#24 | 2024-08-22 ✅ Patent 12,590,328 granted on 2026-03-31

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TARGETED DEPLETION OF NON-TARGET LIBRARY MOLECULES USING POISON PRIMERS DURING TARGET CAPTURE OF NEXT-GENERATION SEQUENCING LIBRARIES

#25 | 2024-08-22 ✅ Patent 12,110,536 granted on 2024-10-08

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Methods of identifying multiple epitopes in cells

#26 | 2024-07-18 ✅ Patent 12,473,538 granted on 2025-11-18

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DP04 POLYMERASE VARIANTS

#27 | 2024-07-11 ✅ Patent 12,365,941 granted on 2025-07-22

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NON-DESTRUCTIVE BILAYER MONITORING USING MEASUREMENT OF BILAYER RESPONSE TO ELECTRICAL STIMULUS

#28 | 2024-07-04 ✅ Patent 12,618,826 granted on 2026-05-05

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MULTI-CHIP PACKAGING OF INTEGRATED CIRCUITS AND FLOW CELLS FOR NANOPORE SEQUENCING

#29 | 2024-06-27

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POLYPEPTIDE TAGGED NUCLEOTIDES AND USE THEREOF IN NUCLEIC ACID SEQUENCING BY NANOPORE DETECTION

#30 | 2024-06-20 ✅ Patent 12,596,098 granted on 2026-04-07

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DEVICE FOR VOLUME COUPLING IN EPITACHOPHORESIS

#31 | 2024-05-23 ✅ Patent 12,479,893 granted on 2025-11-25

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SITE-SPECIFIC BIO-CONJUGATION METHODS AND COMPOSITIONS USEFUL FOR NANOPORE SYSTEMS

#32 | 2024-05-09 ✅ Patent 12,350,891 granted on 2025-07-08

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SYSTEMS AND METHODS FOR FORMING A NANOPORE IN A LIPID BILAYER

#33 | 2024-04-18 ✅ Patent 12,043,919 granted on 2024-07-23

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Immune profiling by primer extension target enrichment

#34 | 2024-02-29 ✅ Patent 11,939,624 granted on 2024-03-26

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Method for labeling ligation products with cell-specific barcodes II

#35 | 2024-02-29 ✅ Patent 11,926,864 granted on 2024-03-12

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Method for labeling ligation products with cell-specific barcodes I

#36 | 2024-02-22 ✅ Patent 12,169,194 granted on 2024-12-17

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And methods for measuring analytes using nanofabricated device

#37 | 2024-02-01 ✅ Patent 12,173,367 granted on 2024-12-24

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Electrical enhancement of bilayer formation

#38 | 2024-01-11 ✅ Patent 12,158,462 granted on 2024-12-03

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Methods for forming a nanopore in a lipid bilayer

#39 | 2024-01-11 ✅ Patent 12,037,366 granted on 2024-07-16

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OMPG variants

#40 | 2024-01-04

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HIGH-THROUGHPUT NUCLEIC ACID SEQUENCING WITH SINGLE-MOLECULE-SENSOR ARRAYS

#41 | 2023-12-28 ✅ Patent 12,297,497 granted on 2025-05-13

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Methods for forming lipid bilayers on biochips

#42 | 2023-12-28 ✅ Patent 12,435,355 granted on 2025-10-07

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WHOLE TRANSCRIPTOME ANALYSIS IN SINGLE CELLS

#43 | 2023-12-21 ✅ Patent 11,932,902 granted on 2024-03-19

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Barcoded beads and method for making the same by split-pool synthesis

#44 | 2023-11-30 ✅ Patent 11,932,903 granted on 2024-03-19

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Kit for split-pool barcoding target molecules that are in or on cells or cell organelles

#45 | 2023-11-09 ✅ Patent 12,297,491 granted on 2025-05-13

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Primer extension target enrichment and improvements thereto including simultaneous enrichment of DNA and RNA

#46 | 2023-11-09 ✅ Patent 12,311,357 granted on 2025-05-27

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Devices for sample analysis using epitachophoresis

#47 | 2023-11-02 ✅ Patent 12,169,185 granted on 2024-12-17

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Tunnel junctions in microfluidic arrays for molecular recognition

#48 | 2023-10-26

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MAGNETIC SENSOR ARRAYS FOR NUCLEIC ACID SEQUENCING AND METHODS OF MAKING AND USING THEM

#49 | 2023-10-19 ✅ Patent 12,091,714 granted on 2024-09-17

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Long lifetime alpha-hemolysin nanopores

#50 | 2023-10-19 ✅ Patent 12,139,743 granted on 2024-11-12

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Method for inline bilayer capacitance monitoring

#51 | 2023-10-05 ✅ Patent 11,781,171 granted on 2023-10-10

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Methods of identifying multiple epitopes in cells

#52 | 2023-09-21 ✅ Patent 12,174,141 granted on 2024-12-24

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Phased nanopore array

#53 | 2023-09-21 ✅ Patent 12,043,648 granted on 2024-07-23

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Alpha-hemolysin variants with altered characteristics

#54 | 2023-09-07 ✅ Patent 12,313,588 granted on 2025-05-27

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Molded flow channel

#55 | 2023-09-07 ✅ Patent 12,209,279 granted on 2025-01-28

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Normalization and baseline shift removal by rotation in added data dimensions

#56 | 2023-08-31

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SINGLE-MOLECULE, REAL-TIME, LABEL-FREE DYNAMIC BIOSENSING WITH NANOSCALE MAGNETIC FIELD SENSORS

#57 | 2023-08-10 ✅ Patent 12,624,393 granted on 2026-05-12

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Deep Sequencing Profiling of Tumors

#58 | 2023-08-10 ✅ Patent 11,981,963 granted on 2024-05-14

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Methods for nucleic acid sequencing by tunneling recognition

#59 | 2023-06-15 ✅ Patent 11,898,204 granted on 2024-02-13

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Generation of single-stranded circular DNA templates for single molecule sequencing

#60 | 2023-06-01 ✅ Patent 11,859,240 granted on 2024-01-02

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Methods of identifying multiple epitopes in cells

#61 | 2023-05-11 ✅ Patent 11,708,599 granted on 2023-07-25

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Methods of identifying multiple epitopes in cells

#62 | 2023-04-27 ✅ Patent 11,692,214 granted on 2023-07-04

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Barcoded beads and method for making the same by split-pool synthesis

#63 | 2023-04-20 ✅ Patent 11,891,661 granted on 2024-02-06

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Non-destructive bilayer monitoring using measurement of bilayer response to electrical stimulus

#64 | 2023-04-06 ✅ Patent 12,416,624 granted on 2025-09-16

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FARADAIC SYSTEMS AND METHODS FOR SELF-LIMITING PROTEIN PORE INSERTION IN AMEMBRANE

#65 | 2023-03-09 ✅ Patent 12,529,100 granted on 2026-01-20

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METHODS FOR REMOVAL OF ADAPTOR DIMERS FROM NUCLEIC ACID SEQUENCING PREPARATIONS

#66 | 2023-02-16 ✅ Patent 11,732,290 granted on 2023-08-22

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Methods of identifying multiple epitopes in cells

#67 | 2023-02-16 ✅ Patent 11,634,752 granted on 2023-04-25

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Kit for split-pool barcoding target molecules that are in or on cells or cell organelles

#68 | 2023-02-16 ✅ Patent 11,667,956 granted on 2023-06-06

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Methods of identifying multiple epitopes in cells

#69 | 2023-01-12

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CHEMICAL METHODS FOR PRODUCING TAGGED NUCLEOTIDES

#70 | 2022-12-01 ✅ Patent 11,753,738 granted on 2023-09-12

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Nanopore forming method and uses thereof

#71 | 2022-11-29 ✅ Patent 11,512,341 granted on 2022-11-29

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Methods of identifying multiple epitopes in cells

#72 | 2022-11-17 ✅ Patent 11,566,278 granted on 2023-01-31

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Methods of identifying multiple epitopes in cells

#73 | 2022-11-03 ✅ Patent 11,773,130 granted on 2023-10-03

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3′ protected nucleotides

#74 | 2022-10-20 ✅ Patent 12,077,817 granted on 2024-09-03

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Methods for creating bilayers for use with nanopore sensors

#75 | 2022-10-06 ✅ Patent 11,754,549 granted on 2023-09-12

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And methods for measuring analytes using nanofabricated device

#76 | 2022-09-29 ✅ Patent 12,482,538 granted on 2025-11-25

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ADAPTIVE COMPRESSION AND MODIFICATION OF NANOPORE MEASUREMENT DATA

#77 | 2022-09-29 ✅ Patent 11,920,184 granted on 2024-03-05

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Concentrating a target molecule for sensing by a nanopore

#78 | 2022-09-22 ✅ Patent 12,566,153 granted on 2026-03-03

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PRINTED ELECTRODE

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Small aperture large electrode cell

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Basecalling for stochastic sequencing processes

#81 | 2022-08-11 ✅ Patent 12,571,059 granted on 2026-03-10

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COMPOSITIONS AND METHODS FOR DETECTION OF EPSTEIN BARR VIRUS (EBV)

#82 | 2022-08-11 ✅ Patent 11,939,632 granted on 2024-03-26

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Nucleic acid sequencing using nanotransistors

#83 | 2022-08-04 ✅ Patent 12,209,984 granted on 2025-01-28

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Differential output of analog memories storing nanopore measurement samples

#84 | 2022-08-04 ✅ Patent 12,595,591 granted on 2026-04-07

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PEPTIDE LIBRARIES HAVING ENHANCED SUBSEQUENCE DIVERSITY AND METHODS FOR USE THEREOF

#85 | 2022-06-23 ✅ Patent 12,121,896 granted on 2024-10-22

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Nucleic acid sequencing by synthesis using magnetic sensor arrays

#86 | 2022-06-16 ✅ Patent 12,037,577 granted on 2024-07-16

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DPO4 polymerase variants

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WHOLE TRANSCRIPTOME ANALYSIS IN SINGLE CELLS

#88 | 2022-06-02 ✅ Patent 12,216,079 granted on 2025-02-04

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Sensor circuit for controlling, detecting, and measuring a molecular complex

#89 | 2022-04-07 ✅ Patent 12,188,079 granted on 2025-01-07

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