ClassID:

20412

A61K31/4985 - page 6 - CPC Classification

Classification description:

Medicinal preparations containing organic active ingredients; Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring heteroatoms, e.g. piperazine Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems

Recent Application in this class:
#1501
20190315755
2019-10-17

Bicyclic heterocyclic derivatives as MNK1 and MNK2 modulators and uses thereof

#1502
20190314369
2019-10-17

Methods of Treating Cancers, Immune and Autoimmune Diseases, and Inflammatory Diseases Based on BTK Occupancy and BTK Resynthesis Rate

#1503
20190308938
2019-10-10

Heterocyclic compounds for the treatment of arenavirus

#1504
20190307746
2019-10-10

Methods of treating cochlear synaptopathy

#1505
20190307745
2019-10-10

SHP2 phosphatase inhibitors and methods of use thereof

#1506
20190300530
2019-10-03

FUSED INDAZOLE PYRIDONE COMPOUNDS AS ANTIVIRALS

#1507
20190298804
2019-10-03

ACTIVATION OF THE ENDOGENOUS ILEAL BRAKE HORMONE PATHWAY FOR ORGAN REGENERATION AND RELATED COMPOSITIONS, METHODS OF TREATMENT, DIAGNOSTICS, AND REGULATORY SYSTEMS

#1508
20190298730
2019-10-03

Pharmaceutical compositions for sustained or delayed release

#1509
20190298729
2019-10-03

Imidazopiperazine inhibitors of transcription activating proteins

#1510
20190298726
2019-10-03

Combined treatment with a TLR7 agonist and an HBV capsid assembly inhibitor

#1511
20190298725
2019-10-03

Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders

#1512
20190290655
2019-09-26

Methods of treating schizophrenia and depression

#1513
20190290644
2019-09-26

Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor

#1514
20190284224
2019-09-19

Cyclic peroxides as prodrugs for selective delivery of agents

#1515
20190284208
2019-09-19

N-[(2,4-difluorophenyl)methyl]-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3] oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide having HIV integrase inhibitory activity

#1516
20190282582
2019-09-19

Pteridine dione monocarboxylate transporter inhibitors

#1517
20190282572
2019-09-19

Combinations comprising substituted imidazo[1,5-a]pyrazinones as PDE1 inhibitors

#1518
20190282571
2019-09-19

Combinations comprising substituted imidazo[1,5-α]pyrazinones as PDE1 inhibitors

#1519
20190282570
2019-09-19

Use of c-Met Inhibitors to Treat Cancers Harbouring MET Mutations

#1520
20190276456
2019-09-12

4-imidazopyridazin-1-yl-benzamides as Btk inhibitors

#1521
20190275048
2019-09-12

METHOD OF TREATING INSOMNIA

#1522
20190275037
2019-09-12

Bruton's tyrosine kinase inhibitors

#1523
20190275036
2019-09-12

Intranasal DHE for the Treatment of Headache

#1524
20190270746
2019-09-05

Heterocyclic inhibitors of PTPN11

#1525
20190270734
2019-09-05

USE OF SELECTIVE GABA A ALPHA 5 NEGATIVE ALLOSTERIC MODULATORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM CONDITIONS

#1526
20190263822
2019-08-29

Pyrazolo [3,4-d] pyrimidine derivative

#1527
20190262367
2019-08-29

ORAL FORMULATIONS MIMETIC OF ROUX-EN-Y GASTRIC BYPASS ACTIONS ON THE ILEAL BRAKE; COMPOSITIONS, METHODS OF TREATMENT, DIAGNOSTICS AND SYSTEMS FOR TREATMENT OF METABOLIC SYNDROME MANIFESTATIONS INCLUDING INSULIN RESISTANCE, FATTY LIVER DISEASE, HYPERLIPIDEMIA, AND TYPE 2 DIABETES

#1528
20190255084
2019-08-22

Diagnostics and methods for treatment of non-alcoholic hepatic steatosis and hepatic steatohepatitis, and prevention of complications thereof

#1529
20190255043
2019-08-22

METHODS OF TREATMENT

#1530
20190248917
2019-08-15

Combination of ABCG2 inhibitors with sacituzumab govitecan (IMMU-132) overcomes resistance to SN-38 in Trop-2 expressing cancers

#1531
20190248794
2019-08-15

SGC stimulators

#1532
20190248753
2019-08-15

Oxazolidinone compounds and methods of use thereof as antibacterial agents

#1533
20190247505
2019-08-15

FILM DOSAGE FORMS CONTAINING AMORPHOUS ACTIVE AGENTS

#1534
20190247393
2019-08-15

METHOD OF THERAPEUTIC ADMINISTRATION OF DHE TO ENABLE RAPID RELIEF OF MIGRAINE WHILE MINIMIZING SIDE EFFECT PROFILE

#1535
20190247390
2019-08-15

Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions

#1536
20190241533
2019-08-08

Compounds and compositions for inhibition of FASN

#1537
20190241532
2019-08-08

Compounds and compositions for inhibition of FASN

#1538
20190240219
2019-08-08

Triazolopyrazine

#1539
20190240218
2019-08-08

Combination treatment for the regenerative therapy of type 1 diabetes mellitus patients

#1540
20190240217
2019-08-08

Polycyclic-carbamoylpyridone compounds and their pharmaceutical use

#1541
20190240212
2019-08-08

Methods of treating RBP4 related diseases with triazolopyridines

#1542
20190233438
2019-08-01

Bicyclic heterocyclic compound

#1543
20190231788
2019-08-01

COMPOSITIONS COMPRISING TIMOLOL AND AN ANTI-INFLAMMATORY AGENT

#1544
20190231785
2019-08-01

PHOSPHODIESTERASE INHIBITOR TREATMENT

#1545
20190231781
2019-08-01

Treatment of congenital adrenal hyperplasia

#1546
20190231780
2019-08-01

Organic compounds

#1547
20190231778
2019-08-01

Methods and compositions for treating cancer

#1548
20190231775
2019-08-01

Methods of Blocking the CXCR-4/SDF-1 Signaling Pathway With Inhibitors of Bruton's Tyrosine Kinase

#1549
20190231705
2019-08-01

HIGH DRUG LOAD POLYMERIC NANOPARTICLE FORMULATIONS AND METHODS OF MAKING AND USING SAME

#1550
20190224280
2019-07-25

Compositions and Methods for Treating Metabolic Diseases

#1551
20190224195
2019-07-25

Oral Capsule Composite Formulation of Dutasteride and Tadalafil

#1552
20190216827
2019-07-18

Composite Formulation of Dutasteride and Tadalafil Comprising Glycerol Fatty Acid Ester Derivative or Propylene Glycol Fatty Acid Ester Derivative and Oral Capsule Formulation Comprising the Same

#1553
20190216806
2019-07-18

NOVEL USES

#1554
20190216782
2019-07-18

Substituted bicyclic compounds as bromodomain inhibitors

#1555
20190211023
2019-07-11

Imidazopyrazinamine phenyl derivative and use thereof

#1556
20190209591
2019-07-11

Therapeutic Combinations of a Proteasome Inhibitor and a BTK Inhibitor

#1557
20190209575
2019-07-11

Use of Sigma-1 receptor agonist compounds

#1558
20190209558
2019-07-11

COMPOUNDS FOR TREATMENT OF FIBROSIS DISEASES

#1559
20190202833
2019-07-04

USE OF A DPP-4 INHIBITOR IN SIRS AND/OR SEPSIS

#1560
20190201396
2019-07-04

Treatment of cancers having alterations within the SWI/SNF chromatin remodeling complex

#1561
20190201395
2019-07-04

SLEEP IMPROVING AGENT

#1562
20190201392
2019-07-04

Use of levocetirizine and montelukast in the treatment of autoimmune disorders

#1563
20190194209
2019-06-27

PYRAZOLE CARBOXAMIDE COMPOUNDS AND METHODS OF USE

#1564
20190194176
2019-06-27

INHIBITORS OF JUN N-TERMINAL KINASE

#1565
20190194159
2019-06-27

Inhibitors of influenza virus replication, application methods and uses thereof

#1566
20190192511
2019-06-27

Amorphous solid dispersions

#1567
20190192504
2019-06-27

Therapeutic heterocyclic compounds

#1568
20190183959
2019-06-20

COMPOSITIONS, KITS AND METHODS FOR TREATING TYPE II DIABETES MELLITUS

#1569
20190183952
2019-06-20

METHODS FOR PREPARING ACTIVE EXTRACT AND APPLICATION THEREOF

#1570
20190183909
2019-06-20

Methods and materials for treating calcific aortic valve stenosis

#1571
20190183888
2019-06-20

Methods and compositions for sleep disorders and other disorders

#1572
20190183886
2019-06-20

Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors

#1573
20190183881
2019-06-20

Use of CDK8 inhibitors to treat diseases of inflammation and autoimmunity

#1574
20190177331
2019-06-13

DOSAGE FORM COMPOSITIONS COMPRISING AN INHIBITOR OF BRUTON'S TYROSINE KINASE

#1575
20190177328
2019-06-13

4,6-substituted-pyrazolo[1,5-a]pyrazines as Janus kinase inhibitors

#1576
20190175592
2019-06-13

Combination of anti-CD20 antibody, P13 kinase-delta selective inhibitor, and BTK inhibitor to treat b-cell proliferative disorders

#1577
20190175591
2019-06-13

PARTICULATE MATERIALS

#1578
20190175590
2019-06-13

Organic compounds

#1579
20190175589
2019-06-13

PHARMACEUTICAL FORMULATIONS, PROCESSES FOR PREPARATION, AND METHODS OF USE

#1580
20190167987
2019-06-06

Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects

#1581
20190167677
2019-06-06

Method of treating metabolic disorders and depression with dopamine receptor agonists

#1582
20190167676
2019-06-06

METHODS FOR IMPROVING RESISTANCE TO SKELETAL MUSCLE FATIGUE

#1583
20190167612
2019-06-06

PHARMACEUTICAL FORMULATION FOR ORAL ADMINISTRATION WITH CONTROLLED DISSOLUTION RATE COMPRISING SUSTAINED-RELEASE PELLETS CONTAINING TAMSULOSIN HYDROCHLORIDE

#1584
20190161501
2019-05-30

Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect

#1585
20190160064
2019-05-30

Methods for treating skeletal muscle cachexia arising from burn injury by administering PDE4B-selective inhibitors

#1586
20190160061
2019-05-30

6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2 receptors

#1587
20190160060
2019-05-30

Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation

#1588
20190152990
2019-05-23

POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY

#1589
20190152978
2019-05-23

Chemokine receptor modulators and uses thereof

#1590
20190152949
2019-05-23

Therapeutic compounds and uses thereof

#1591
20190151321
2019-05-23

Treatment and prevention of atherothrombosis by inhibition of bruton's tyrosine kinase (BTK)

#1592
20190151311
2019-05-23

Anti-neoplastic combinations and dosing regimens using CDK4/6 inhibitor compounds to treat Rb-positive tumors

#1593
20190151294
2019-05-23

TREATMENT OF ALCOHOLISM AND DEPRESSION AND/OR DYSPHORIC MOOD USING IBUDILAST

#1594
20190142941
2019-05-16

BCL-XL Inhibitory Compounds Having Low Cell Permeability and Antibody Drug Conjugates Including the Same

#1595
20190142828
2019-05-16

Regimens and compositions for treating HIV infections and AIDS

#1596
20190142827
2019-05-16

Compounds for treatment of cancer

#1597
20190142793
2019-05-16

SGLT-2 inhibitors for treating metabolic disorders in patients with renal impairment or chronic kidney disease

#1598
20190134173
2019-05-09

Ovarian cancer vaccines

#1599
20190134056
2019-05-09

K-RAS MUTATIONS AND ANTAGONISTS

#1600
20190134055
2019-05-09

Treatment of addiction and impulse-control disorders using PDE7 inhibitors

#1601
20190134031
2019-05-09

Anticancer agents

#1602
20190134030
2019-05-09

Dipeptidyl peptidase-4 inhibitors for topical eye treatment of retinal neurodegenerative diseases

#1603
20190134029
2019-05-09

Carboxamide derivatives useful as rsk inhibitors

#1604
20190134028
2019-05-09

Substituted dipyrido[1,2-a:1′,2′-d]pyrazines for treating viral infections

#1605
20190133960
2019-05-09

Double-layer tablet and painkiller tablet with same structure

#1606
20190133959
2019-05-09

Hypnotics tablet with double-layer structure

#1607
20190127365
2019-05-02

INHIBITORS OF HEPATITIS C VIRUS REPLICATION

#1608
20190125685
2019-05-02

COMPOSITE CAPSULE PREPARATION CONTAINING TADALAFIL AND TAMSULOSIN AND HAVING IMPROVED STABILITY AND ELUTION RATE

#1609
20190119268
2019-04-25

HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS

#1610
20190117679
2019-04-25

Imidazopyridines Syk inhibitors

#1611
20190117658
2019-04-25

NOVEL COMPOSITIONS AND METHODS

#1612
20190117656
2019-04-25

Fused heterotricyclic organic compounds, pharmaceutical compositions, and medical uses thereof

#1613
20190111068
2019-04-18

COMBINATION FORMULATION OF TWO ANTIVIRAL COMPOUNDS

#1614
20190105321
2019-04-11

TREATMENT FOR DIABETES IN PATIENTS INAPPROPRIATE FOR METFORMIN THERAPY

#1615
20190105305
2019-04-11

Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof

#1616
20190099420
2019-04-04

Systems pharmacology for treating ocular disorders

#1617
20190099368
2019-04-04

CHEWABLE DOSAGE FORMS CONTAINING SITAGLIPTIN AND METFORMIN

#1618
20190099367
2019-04-04

Chewable dosage forms containing sitagliptin and metformin

#1619
20190092787
2019-03-28

Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections

#1620
20190091220
2019-03-28

TARGETING PARP1 FOR TREATMENT OF TSC AND CANCERS

#1621
20190084946
2019-03-21

Methods using HDAC11 inhibitors

#1622
20190084945
2019-03-21

Methods using HDAC11 inhibitors

#1623
20190083502
2019-03-21

Treatment of erectile dysfunction and other indications

#1624
20190083494
2019-03-21

Therapeutic Compositions

#1625
20190083491
2019-03-21

Small molecules inhibitors of RAD51

#1626
20190083403
2019-03-21

Orally Disintegrating Tablet Formulation For Enhanced Bioavailability

#1627
20190071445
2019-03-07

Pharmaceutical compositions comprising 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl) butan-1-one for inhibiting serotonin reuptake transporter activity

#1628
20190070158
2019-03-07

Veterinary composition comprising imidacloprid, moxidectin and praziquantel for cutaneous topical application (spot on), for the treatment and prevention of ecto and endoparasitoses affecting dogs

#1629
20190062334
2019-02-28

Organic compounds

#1630
20190060242
2019-02-28

RAPIDLY DISINTEGRATING TABLET COMPOSITIONS OF DPP-IV INHIBITORS WITH LOW MINERAL CONTENT

#1631
20190055199
2019-02-21

Biaryl derivative and medicine containing same

#1632
20190048084
2019-02-14

ANTI-PD-L1 COMBINATIONS FOR TREATING TUMORS

#1633
20190047998
2019-02-14

Nitrogen-containing heterocycle and carbocycle derivatives having TrkA inhibitory activity

#1634
20190046527
2019-02-14

METHODS OF TREATING CROHN'S DISEASE AND ULCERATIVE COLITIS

#1635
20190046526
2019-02-14

POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE

#1636
20190046507
2019-02-14

COMPOUNDS FOR THE TREATMENT OF MALARIA

#1637
20190038606
2019-02-07

Use of Gaboxadol in the treatment of diabetes and related conditions

#1638
20190038597
2019-02-07

PREVENTION OF VASCULAR AND CARDIAC FIBROSIS VIA IRE1ALPHA INHIBITION

#1639
20190031685
2019-01-31

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

#1640
20190030036
2019-01-31

PHOSPHODIESTERASE INHIBITOR TREATMENT

#1641
20190025287
2019-01-24

Methods of measuring signaling pathway activity for selection of therapeutic agents

#1642
20190023714
2019-01-24

PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-alpha]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF

#1643
20190022093
2019-01-24

Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer

#1644
20190022092
2019-01-24

Therapeutic Combinations of a BTK Inhibitor and a GITR Binding Molecule, a 4-1BB Agonist, or an OX40 Agonist

#1645
20190022003
2019-01-24

Liposome formulation for delivery of Wnt signal pathway inhibitor

#1646
20190016808
2019-01-17

Anti-EGFR combinations for treating tumors

#1647
20190016706
2019-01-17

Small molecule IRE1-α inhibitors

#1648
20190016701
2019-01-17

TRPA1 modulators

#1649
20190010162
2019-01-10

Positive allosteric modulators of the GLP-1 receptor

#1650
20190010160
2019-01-10

Salt of quinolone compound, polymorphs thereof, preparation method therefor, composition, and applications

#1651
20190008870
2019-01-10

COMPOSITIONS AND METHODS FOR LIPID METABOLISM DISORDER

#1652
20190008869
2019-01-10

Therapeutic Combinations of an Antifolate and a BTK Inhibitor

#1653
20190008860
2019-01-10

Agent for preventing and/or treating Alzheimer's disease

#1654
20190008859
2019-01-10

Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor

#1655
20190008858
2019-01-10

Inhibitors of hepatitis C virus

#1656
20190000855
2019-01-03

TREATMENT OF GENOTYPED DIABETIC PATIENTS WITH DPP-IV INHIBITORS SUCH AS LINAGLIPTIN

#1657
20190000753
2019-01-03

NASAL DOSAGE FORMS OF DIHYDROERGOTAMINE

#1658
20180370969
2018-12-27

6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

#1659
20180370966
2018-12-27

METHODS OF TREATMENT USING PYRIDINONYL PDK1 INHIBITORS

#1660
20180370933
2018-12-27

Compounds and compositions for inhibition of FASN

#1661
20180369244
2018-12-27

BTK Inhibitors to Treat Solid Tumors Through Modulation of the Tumor Microenvironment

#1662
20180369241
2018-12-27

TREATMENT OF CANCER WITH DNAPK INHIBITORS

#1663
20180369145
2018-12-27

Methods for the preparation of biologically active compounds in nanoparticulate form

#1664
20180362532
2018-12-20

Hexahydropyrazinotriazinone derivatives as kinase inhibitors

#1665
20180360831
2018-12-20

Tetrahydropyridopyrazine modulators of GPR6

#1666
20180360830
2018-12-20

COMPOUNDS, COMPOSITIONS AND METHODS OF AGELASTATIN ALKALOIDS

#1667
20180360818
2018-12-20

Methods of treating RBP4 related diseases with triazolopyridines

#1668
20180354951
2018-12-13

Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors

#1669
20180354908
2018-12-13

Pharmaceutical compound

#1670
20180353513
2018-12-13

Uses of DPP IV inhibitors

#1671
20180346572
2018-12-06

Anti-PD-L1 combinations for treating tumors

#1672
20180346486
2018-12-06

Heterocyclic compounds

#1673
20180344802
2018-12-06

Pharmaceutical formulation for bedwetting and method of use thereof

#1674
20180344674
2018-12-06

EXTENDED-RELEASE FORMULATION FOR REDUCING THE FREQUENCY OF URINATION AND METHOD OF USE THEREOF

#1675
20180339993
2018-11-29

AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS

#1676
20180339981
2018-11-29

Compounds for preventing, inhibiting, or treating cancer, aids and/or premature aging

#1677
20180338988
2018-11-29

Compositions for treating neurological disorders

#1678
20180338982
2018-11-29

Cooperative Medication Combination Systems

#1679
20180333410
2018-11-22

METHOD OF TREATING A PATIENT WITH A CYP3A4 SUBSTRATE DRUG

#1680
20180333409
2018-11-22

Method of treating a patient with a CYP3A4 substrate drug

#1681
20180325896
2018-11-15

Substituted imidazo[1,2-a]pyrazines as Syk inhibitors

#1682
20180319798
2018-11-08

1,3,4,8-Tetrahydro-2H-Pyrido[1,2-a]Pyrazine Derivative and Use of the Same as HIV Integrase Inhibitor

#1683
20180319794
2018-11-08

Amino-substituted imidazo[1,2-A] pyridinecarboxamides and their use

#1684
20180319783
2018-11-08

Ferroportin inhibitors

#1685
20180319780
2018-11-08

INHIBITORS OF JUN N-TERMINAL KINASE

#1686
20180318380
2018-11-08

Methods of treating muscular dystrophy

#1687
20180318307
2018-11-08

METHODS OF USE OF INHIBITORS OF PHOSPHODIESTERASES AND MODULATORS OF NITRIC OXIDE, REACTIVE OXYGEN SPECIES, AND METALLOPROTEINASES IN THE TREATMENT OF PEYRONIE'S DISEASE, ARTERIOSCLEROSIS AND OTHER FIBROTIC DISEASES

#1688
20180318304
2018-11-08

Methods of Using BTK Inhibitors to Treat Dermatoses

#1689
20180318297
2018-11-08

Imidazopyrazine inhibitors of Bruton's tyrosine kinase

#1690
20180312524
2018-11-01

Benzopiperazine compositions as BET bromodomain inhibitors

#1691
20180312507
2018-11-01

Fused indazole pyridone compounds as antivirals

#1692
20180311314
2018-11-01

Glucokinase activator compositions for the treatment of diabetes

#1693
20180311248
2018-11-01

COMPOUNDS AND COMPOSITIONS FOR TREATING CHEMICAL WARFARE AGENT-INDUCED INJURIES

#1694
20180311237
2018-11-01

COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS

#1695
20180305359
2018-10-25

Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors

#1696
20180305354
2018-10-25

COMT inhibiting methods and compositions

#1697
20180305311
2018-10-25

Synergistic compositions

#1698
20180298016
2018-10-18

Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof

#1699
20180297998
2018-10-18

Intermediate compounds for preparation of praziquantel and processes for preparing the intermediate compounds

#1700
20180297991
2018-10-18

Ferroportin inhibitors

#1701
20180296558
2018-10-18

Combinations

#1702
20180296557
2018-10-18

Survivin-targeting anti-tumor agents and uses thereof

#1703
20180290987
2018-10-11

OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS

#1704
20180289718
2018-10-11

FUSED IMIDAZOLE COMPOUNDS

#1705
20180289714
2018-10-11

Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions

#1706
20180289705
2018-10-11

NK-3 receptor antagonists for therapeutic or cosmetic treatment of excess body fat

#1707
20180289632
2018-10-11

Treatment of addiction and impulse-control disorders using PDE7 inhibitors

#1708
20180282282
2018-10-04

ISOQUINOLINES AS INHIBITORS OF HPK1

#1709
20180280518
2018-10-04

LINEAR POLYSACCHARIDE BASED FILM PRODUCTS

#1710
20180280387
2018-10-04

SYK INHIBITORS

#1711
20180280356
2018-10-04

Non-hydrophobic compounds for use in treating metastasis and/or cartilage defect

#1712
20180273537
2018-09-27

Compositions and methods for treating toxoplasmosis, cryptosporidiosis and other apicomplexan protozoan related diseases

#1713
20180271871
2018-09-27

Bumped kinase inhibitor compositions and methods for treating cancer

#1714
20180271862
2018-09-27

Transmucosal and subcutaneous compositions

#1715
20180271859
2018-09-27

TREATMENT FOR DIABETES IN PATIENTS INAPPROPRIATE FOR METFORMIN THERAPY

#1716
20180265525
2018-09-20

Polycyclic pyridone derivative having integrase inhibitory activity

#1717
20180265516
2018-09-20

Substituted triazolopiperazine PARP inhibitor, preparation method therefor and use thereof

#1718
20180263978
2018-09-20

Bromocriptine formulations

#1719
20180263977
2018-09-20

Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor

#1720
20180263959
2018-09-20

Methods of treating muscular dystrophy

#1721
20180258104
2018-09-13

Substituted cyclopropanes as PDE-10 inhibitors

#1722
20180258096
2018-09-13

6,7-dihydropyrazolo[1,5-α]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2 receptors

#1723
20180256660
2018-09-13

PLANT EXTRACTS WITH ANTI-DIABETIC AND OTHER USEFUL ACTIVITIES

#1724
20180256569
2018-09-13

Substituted 6,7-dihydropyrazolo[1,5-a]pyrazines as negative allosteric modulators of mGluR2 receptors

#1725
20180256550
2018-09-13

Target for treating hepatitis B virus

#1726
20180251459
2018-09-06

Compositions comprising macrocycle derivatives incorporating bridged macrocycles and methods of producing and using same

#1727
20180250400
2018-09-06

Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a CDK4/6 Inhibitor

#1728
20180250298
2018-09-06

Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor, a JAK-2 inhibitor, and/or a BCL-2 inhibitor

#1729
20180250297
2018-09-06

Methods, compositions, and uses of novel Fyn kinase inhibitors

#1730
20180244667
2018-08-30

Pyrido-azaheterecydic compound and preparation method and use thereof

#1731
20180244626
2018-08-30

Aminoindazole derivatives as sodium channel inhibitors

#1732
20180243319
2018-08-30

Modulation of solubility, stability, absorption, metabolism, and pharmacokinetic profile of lipophilic drugs by sterols

#1733
20180243227
2018-08-30

MESOSCALE NANOPARTICLES FOR SELECTIVE TARGETING TO THE KIDNEY AND METHODS OF THEIR THERAPEUTIC USE

#1734
20180237491
2018-08-23

Optogenetic inhibition of overactive neuronal activity

#1735
20180237446
2018-08-23

N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders

#1736
20180235960
2018-08-23

Treatment of cancer with TOR kinase inhibitors

#1737
20180235943
2018-08-23

Combination therapies for treatment of spinal muscular atrophy

#1738
20180230168
2018-08-16

Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors

#1739
20180230165
2018-08-16

Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication

#1740
20180230151
2018-08-16

Process for the preparation of triazole and salt thereof

#1741
20180230115
2018-08-16

cGAS antagonist compounds

#1742
20180228881
2018-08-16

Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy

#1743
20180228826
2018-08-16

FIXED-DOSE COMBINATIONS OF ANTIVIRAL COMPOUNDS

#1744
20180228776
2018-08-16

Indazolyl-oxo-isothiazole compounds

#1745
20180222914
2018-08-09

Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof

#1746
20180222913
2018-08-09

Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof

#1747
20180221479
2018-08-09

Agents for use in the treatment of glioma

#1748
20180221373
2018-08-09

Method of treating insomnia

#1749
20180221368
2018-08-09

Substituted benzoxazepine for cancer therapy

#1750
20180215763
2018-08-02

Compounds and methods for CDK8 modulation and indications therefor

#1751
20180215758
2018-08-02

Tyrosine amide derivatives as Rho-kinase inhibitors

#1752
20180208600
2018-07-26

BICYCLIC HETEROCYCLIC DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF

#1753
20180208596
2018-07-26

Pharmaceutical composition comprising a crystal form of (S)-4-(8-amino-3-(1-(but-2-ynoyl) pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

#1754
20180207154
2018-07-26

Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor and/or a JAK-2 Inhibitor

#1755
20180207153
2018-07-26

Urea derivative or pharmacologically acceptable salt thereof

#1756
20180201611
2018-07-19

Respiratory formulations and compounds for use therein

#1757
20180200256
2018-07-19

Methods

#1758
20180200254
2018-07-19

ANTIVIRAL THERAPY

#1759
20180200253
2018-07-19

Heteroaromatic Compounds and their Use as Dopamine D1 Ligands

#1760
20180200252
2018-07-19

Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-(trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one, a solid form thereof and methods of their use

#1761
20180200247
2018-07-19

Substituted Tetrahydroquinolinone Compounds as ROR Gamma Modulators

#1762
20180199573
2018-07-19

CHEWABLE COMPOSITION COMPRISING A PHARMACEUTICALLY ACTIVE INGREDIENT

#1763
20180194772
2018-07-12

NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders

#1764
20180194746
2018-07-12

Compounds for the treatment of HIV

#1765
20180193337
2018-07-12

Methods of Blocking the CXCR-4/SDF-1 Signaling Pathway With Inhibitors of Bruton's Tyrosine Kinase

#1766
20180193322
2018-07-12

Thienopyridine derivative for the treatment of hepatitis C infections

#1767
20180193302
2018-07-12

Ultra low dose doxepin and methods of using the same to treat sleep disorders

#1768
20180186805
2018-07-05

Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-#a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-#carboxamide and solid state forms thereof

#1769
20180186783
2018-07-05

Inhibitors of protein kinases

#1770
20180186775
2018-07-05

Quinoxaline derivatives useful as FGFR kinase modulators

#1771
20180186772
2018-07-05

6-(5-hydroxy-1H-pyrazol-1-yl)nicotinamide inhibitors of PHD

#1772
20180186771
2018-07-05

Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them

#1773
20180186768
2018-07-05

Antibacterial compounds

#1774
20180185361
2018-07-05

Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy

#1775
20180185347
2018-07-05

TETRAHYDROCYCLOPENTA[B]INDOLE COMPOUNDS AND PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF THE SIGNS AND SYMPTOMS OF BHP

#1776
20180185336
2018-07-05

PARASITICIDAL ORAL VETERINARY COMPOSITIONS COMPRISING SYSTEMICALLY-ACTING ACTIVE AGENTS, METHODS AND USES THEREOF

#1777
20180185318
2018-07-05

Combination methods and compositions including sleep therapeutics for treating mood

#1778
20180179522
2018-06-28

Tunable endogenous protein degradation

#1779
20180179229
2018-06-28

Pyridone and aza-pyridone compounds and methods of use

#1780
20180179212
2018-06-28

4-imidazopyridazin-1-yl-benzamides as BTK inhibitors

#1781
20180179209
2018-06-28

Substituted pyrazoles as JAK inhibitors

#1782
20180179172
2018-06-28

Glucagon-like peptide 1 modulator and uses thereof

#1783
20180177784
2018-06-28

HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS

#1784
20180169109
2018-06-21

Targeted protein degradation to attenuate adoptive T-cell therapy associated adverse inflammatory responses

#1785
20180169096
2018-06-21

Heterocyclic compounds for treating psoriasis

#1786
20180169043
2018-06-21

COMPOSITIONS AND METHODS FOR THE REDUCTION OR PREVENTION OF HEPATIC STEATOSIS

#1787
20180169028
2018-06-21

Nanoparticle Composition and Methods for Synthesis Thereof

#1788
20180162878
2018-06-14

Anti-pulmonary tuberculosis nitroimidazole derivative

#1789
20180162865
2018-06-14

Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluorethyl)pyrrolidine-1-carboxamide and solid state forms thereof

#1790
20180162859
2018-06-14

TETRACYCLIC AUTOTAXIN INHIBITORS

#1791
20180161337
2018-06-14

Bicyclic bromodomain inhibitors

#1792
20180161325
2018-06-14

Pharmaceutical formulation containing tadalafil

#1793
20180155365
2018-06-07

Tetracyclic heterocycle compounds useful as HIV integrase inhibitors

#1794
20180153887
2018-06-07

POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE

#1795
20180153882
2018-06-07

Aza spiro alkane derivatives as inhibitors of metalloproteases

#1796
20180153830
2018-06-07

SELECTIVE INHIBITORS OF UNDIFFERENTIATED CELLS

#1797
20180147263
2018-05-31

METHOD OF TREATING NEUROLOGICAL DISORDER BY ENHANCING OUTGROWTH OF NEURITE

#1798
20180147205
2018-05-31

Therapeutic Compositions

#1799
20180141955
2018-05-24

Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-alpla]pyrrolo[2,3-e]-pyrazin-8-YL)-N-(2,2,2-Trifluoroethyl)pyrrol and solid state forms thereof

#1800
20180140675
2018-05-24

Combination of dopamine agonists plus first phase insulin secretagogues for the treatment of metabolic disorders