20918 ⎘
Medicinal preparations containing peptides; Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Enhanced reconstitution and autoreconstitution of the hematopoietic compartment
#2102Lipid based nanocarrier compositions loaded with metal nanoparticles and therapeutic agent
#2103Methods for inducing cell division of postmitotic cells
#2104C1-INH compositions and methods for the prevention and treatment of disorders associated with C1 esterase inhibitor deficiency
#2105C1-INH compositions and methods for the prevention and treatment of disorders associated with C1 esterase inhibitor deficiency
#2106TAFA4 COMPOUNDS AND USES THEREOF FOR TREATING PAIN
#2107METHODS AND COMPOSITIONS FOR USING MHC CLASS II INVARIANT CHAIN POLYPEPTIDES AS A RECEPTOR FOR MACROPHAGE MIGRATION INHIBITORY FACTOR
#2108Myelin oligodendrocyte glycoprotein, myelin basic protein, and proteolipid protein compositions and methods of use
#2109Compositions and methods for inhibiting tumor cells by inhibiting the transcription factor ATF5
#2110Agent for prevention or treatement of corneal disorders
#2111Method and pharmaceutical composition for use in the treatment of diabetes
#2112Therapeutic gene cocktail for heart regeneration
#2113METHODS, COMPOSITIONS, AND KITS INVOLVING ALTERATION OF THE CHAPERONE PROTEIN AXIS IN A SUBJECT
#2114METHODS OF TREATING IRON OVERLOAD
#2115Compositions and methods for the induction and tuning of gene expression
#2116Epicardial-derived paracrine factors for repairing cardiac tissue
#2117EXTRACELLULAR HISTONES AS BIOMARKERS FOR PROGNOSIS AND MOLECULAR TARGETS FOR THERAPY
#2118Methods of inducing vascular morphogensis
#2119Method for detecting anti-vinculin antibodies in a subject with an IBS symptom
#2120Use of CD36 to identify cancer subjects for treatment
#2121LIPID NANOPARTICLE COMPOSITIONS
#2122C1-INH compositions and methods for the prevention and treatment of disorders associated with C1 esterase inhibitor deficiency
#2123Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins and applications thereof
#2124STING (Stimulator of Interferon Genes), A Regulator of Innate Immune Responses
#2125Ezetimibe-associated ApoA-I mimetic peptides showing enhanced synergism
#2126TRPV3 agonists for the treatment of skin conditions
#2127Viral vectors for the treatment of retinal dystrophy
#2128Rapamycin 40-O-Cyclic Hydrocarbon Esters, Compositions and Methods
#2129Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins
#2130Hot flash-suppressing agent
#2131METHODS AND COMPOSITIONS FOR TREATING ALZHEIMER'S DISEASE AND OTHER MEMORY-ASSOCIATED DISORDERS AND CONDITIONS
#2132Alpha connexin C-terminal (ACT) peptides and methods of use thereof
#2133Anti-CSPG4 reagents and methods of treating cancer
#2134Mast cell stabilizers for treatment of hypercytokinemia and viral infection
#2135Transcription factor-based generation of pacemaker cells and methods of using same
#2136Alpha connexin c-terminal (ACT) peptides and methods of use thereof
#2137Method for treating cancer by adminstering poly I:C and LAG-3-IgG fusion protein
#2138RECOMBINANT AAV VECTORS USEFUL FOR REDUCING IMMUNITY AGAINST TRANSGENE PRODUCTS
#2139p63 inactivation for the treatment of heart failure
#2140COMPOSITIONS AND METHODS FOR REGULATING SAS1R
#2141Mast cell stabilizers for treatment of hypercytokinemia and viral infection
#2142Peptide for promoting hair growth
#2143Method of ameliorating or preventing the worsening or the progression of symptoms of BPH
#2144LIQUID NUTRITIONAL FORMULA FOR TYROSINEMIA PATIENTS
#2145Compositions and methods for nucleic acid transfer
#2146Removal of serine proteases by treatment with finely divided silicon dioxide
#2147Methods and compositions for regenerating tissues
#2148Tumor specific oligosaccharide epitopes and use thereof
#2149Method of prevention and inhibition of preterm labor
#2150Prevention and/or treatment of hearing loss or impairment
#2151COMPOSITIONS COMPRISING SEMAPHORINS FOR THE TREATMENT OF CANCER AND METHODS OF SELECTION THEREOF
#2152Cell-permeable (iCP)-SOCS3 recombinant protein and uses thereof
#2153Use of Glycomacropeptide to Improve Women's Health
#2154METHOD OF DIAGNOSIS, PROGNOSIS OR TREATMENT OF NEURODEGENERATIVE DISEASES
#2155RP2 and RPGR vectors for treating X-linked retinitis pigmentosa
#2156TREATMENT OF EYE DISEASE
#2157Glucocerebroside treatment of liver disorders
#2158Methods for treating refractory anemia with ringed sideroblasts
#2159AAV-mediated gene therapy for RPGR X-linked retinal degeneration
#2160Use of haptoglobin subunit for promoting wound healing
#2161Treatment agent for cognitive impairment induced by amyloid beta-protein, therapeutic agent for alzheimer's disease, and treatment method and pathological analysis method related to these
#2162Dermatopontin as a therapeutic for metabolic disorders
#2163Use of haptoglobin subunit for promoting angiogenesis
#2164Combination therapy for treatment of coronary artery disease
#2165PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF CANCER COMPRISING EI24 PROTEIN OR ITS ENCODING GENE
#2166Semaphorin 3A for treatment and assessment of severity of inflammatory bowel disease
#2167A PROTEIN BASED ON ZG16 FOR USE AS A MEDICAMENT
#2168MCJ agonists and uses therefor
#2169Compostions for Treating Dry Eye Disease
#2170Technology for the Preparation of Microparticles
#2171CNS delivery of MRNA and uses thereof
#2172Frizzled-4 mutation indicator of retinopathy and intrauterine growth restriction
#2173CHEMOREPULSION OF CELLS
#2174SELECTIVE TARGETING OF THE CD40L/MAC-1 INTERACTION BY SMALL PEPTIDE INHIBITORS AND ITS USE FOR THE TREATMENT OF INFLAMMATION AND ATHEROGENESIS
#2175Avian follistatin product
#2176Methods and compositions for modulating toso activity
#2177Human neutrophil gelatinase-associated lipocalin (hNGAL) muteins capable of binding angiopoietin-2 (Ang-2) and methods of use thereof
#2178THERAPEUTIC AND PROPHYLACTIC METHODS, USES AND COMPOSITIONS COMPRISING ANEXIN A5
#2179Use of PRG4 as an anti-inflammatory agent
#2180Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases
#2181ANTAGONISTS OF ACTRIIB AND USES FOR INCREASING RED BLOOD CELL LEVELS
#2182Composition and system for separating and detecting alpha-fetoprotein variant and use thereof
#2183Modified ligand-gated ion channels and methods of use
#2184Arginine-rich Peptide Mixture, their Application Thereof in Cervical Cancer Therapy, and a Process for Producing same
#2185Compositions and methods of increasing longevity or treating cellular stress
#2186ID4 PROTEIN RESTORES WILD TYPE P53 ACTIVITY
#2187RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF
#2188METHODS OF TREATING RETINAL DISEASES
#2189Pharmaceutical composition for preventing or treating diabetic complications and screening method for preventive or therapeutic agent for diabetic complications
#2190Compositions of active WNT protein
#2191Inflammatory disease diagnosis and methods of treatment using down-regulators of lipopolysaccharide-responsive beige-like anchor
#2192Compositions and methods for inhibiting tumor cells by inhibiting the transcription factor ATF5
#2193Use of angiogenin or angiogenin agonists for treating diseases and disorders
#2194Tablets comprising GLP-1 agonist and enteric coating
#2195Use of peptide-based inhibitors of the stat3-IL10 pathway for treating bacterial infection and granulomatous disease
#2196Immunotherapy against several tumors including gastrointestinal and gastric cancer
#2197Human disease mitigation with food formulation
#2198Compositions and Methods for Treating Conditions That Affect Epidermis
#2199Polymeric Nanoparticle
#2200Methods and compositions for reducing growth, migration and invasiveness of brain cancer stem cells and improving survival of patients with brain tumors
#2201Methods of treating cognitive impairment
#2202Co-activation of mTOR and STAT3 pathways to promote neuronal survival and regeneration
#2203Method of treating cancer with a multiple integrin binding Fc fusion protein
#2204STAT3 and ERK signal pathway inhibitor comprising mogrosides and analogs thereof
#2205HIGH DENSITY LIPOPROTEIN FUNCTIONALIZED MAGNETIC NANOSTRUCTURES
#2206Treatment of angiogenesis disorders
#2207ANTI-ARRHYTHMICITY AGENTS
#2208Methods for treating and preventing cardiomyopathy with a fusion protein of tafazzin and a cellular permeability peptide
#2209Method of preventing or reducing the progression of prostate cancer
#2210Factors and cells that provide for induction of bone, bone marrow, and cartilage
#2211COMPOSITIONS AND METHODS OF TREATING TUMORS
#2212MORTALIN PEPTIDES AND ANTIBODIES AND USES THEREOF FOR INHIBITING MORTALIN ACTIVITY AND TREATING A DISEASE ASSOCIATED WITH A PATHOLOGICAL CELL
#2213Fibronectin based scaffold domain proteins that bind to myostatin
#2214High density lipoprotein nanoparticles for inflammation
#2215Therapeutic effects of NURR1 and FOXA2 in inflammatory neurologic disorders by M1-to-M2 polarization of glial cells
#2216Pharmaceuticals and methods for treating hypoxia and screening methods therefor
#2217Compositions and methods for treating mesothelioma post-surgery
#2218AAV-MEDIATED GENE THERAPY FOR NPHP5 LCA-CILIOPATHY
#2219Biomarkers for seizures
#2220Materials and Methods Useful For Treating Glioblastoma
#2221CAMKK1 as a novel regenerative therapeutic
#2222Use of hepcidin as a regulator of iron homeostasis
#2223Tear lipocalin muteins binding IL-4 R alpha
#2224Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody
#2225METHODS AND COMPOSITIONS FOR TREATING AMYLOID DEPOSITS
#2226Methods and compositions for delivering interleukin-1 receptor antagonist
#2227Targeted Delivery Platform for Delivery of Therapeutics
#2228Methods and compositions for modulating myofibroblast activities
#2229Whey Protein Micelles to Enhance Muscle Mass and Performance
#2230Pharmaceutical composition for preventing or treating metabolic diseases, comprising bacteroides acidifaciens as active ingredient
#2231Topically Active Steroids For Use in Radiation and Chemotherapeutics Injury
#2232Autoantigen in idiopathic inflammatory myopathies
#2233CARTILAGE-BINDING FUSION PROTEINS
#2234Peptides and compositions for treatment of joint damage
#2235BEVERAGE, AND METHOD OF PRODUCING THE SAME
#2236Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
#2237Compositions and methods for treating eye infections and disease
#2238COMPOSITIONS AND METHODS FOR TREATING EYE INFECTIONS AND DISEASE
#2239Modulators of ACYL-COA lysocardiolipin acyltransferase 1 (ALCAT1) and uses thereof
#2240Methods of increasing sarcolemmal utrophin
#2241IMMUNOTHERAPY AGAINST SEVERAL TUMORS, SUCH AS LUNG CANCER, INCLUDING NSCLC
#2242Method for treating microbial infection
#2243METHOD OF TREATING MUCUS HYPERSECRETION
#2244PREVENTION AND TREATMENT OF INFECTIONS
#2245BIOACTIVE COMPOSITIONS DERIVABLE FROM PLATELET CONCENTRATES, AND METHODS FOR PREPARING AND USING SAME
#2246Immunosuppressive blood cells and methods of producing the same
#2247Treatment and diagnosis of melanoma
#2248INCREASING ATOH1 LIFE TO DRIVE SENSORINEURAL HAIR CELL DIFFERENTIANTION
#2249NOVEL WOUND-HEALING-ENHANCING DEVICES
#2250Cytokines and neuroantigens for treatment of immune disorders
#2251Immunotherapy against several tumors including gastrointestinal and gastric cancer
#2252TOPICAL USE OF PRG4 FOR TREATMENT OF ALLERGY AND SYMPTOMS OF INFLAMMATION
#2253METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISORDERS
#2254Methods and compositions for in vivo induction of pancreatic beta cell formation
#2255METHODS FOR TREATING A NEUROLOGICAL DISORDER IN A SUBJECT USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) PROYL HYDROXYLASE
#2256Tmem100 peptides and variants thereof and their use in treating or preventing diseases or conditions
#2257SYNTHETIC PEPTIDES
#2258Adeno-associated viral vectors for treating myocilin (MYOC) glaucoma
#2259Regenerating functional neurons for treatment of disease and injury in the nervous system
#2260Treatment of cancer and inhibition of metastasis using hemoglobin beta subunit
#2261Treatment of hormonal disorders of growth
#2262NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING GASTROINTESTINAL AND GASTRIC CANCER
#2263POLYMER CONJUGATES OF BOX-A OF HMGB1 AND BOX-A VARIANTS OF HMGB1
#2264DETECTION AND TREATMENT OF BREAST CANCER
#2265Compositions comprising GRIM-19 therapeutics and methods of use
#2266Use of a small native peptide activator of SERCA pump for treatment of heart failure and other disorders characterized by cytosolic calcium overload
#2267Methods for treatment of stroke or cerebrovascular accidents using an ETreceptor agonist
#2268GLA DOMAINS AS TARGETING AGENTS
#2269Osteogenic biomaterial
#2270TREATMENT OF NEURODEVELOPMENTAL DISORDERS
#2271Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various diseases
#2272Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
#2273OLIGONUCLEOTIDES FOR REDUCTION OF PD-L1 EXPRESSION
#2274Animal model of longevity and related methods for increasing longevity and inhibiting tumorigenesis
#2275Compositions and methods for the systemic treatment of arthritis
#2276Methods and uses of slit for treating fibrosis
#2277USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES
#2278Peptidyl calcineurin inhibitors
#2279Lipid formulations for delivery of messenger RNA
#2280Methods for increasing red blood cell levels and treating ineffective erythropoiesis
#2281Therapeutic and research application of PDCL3
#2282COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF NEUROLOGICAL DISEASE
#2283Sugar compositions for treating hemophilia A and/or Von Willebrand disease
#2284Fusion protein comprising albumin and retinol-binding protein
#2285Compositions and Methods for Increasing Red Blood Cells
#2286Use of EI24 gene
#2287Functions of 55 Newfound Proteins and Their Medicinal Application in the Treatment and Prevention of Disease
#2288PROTEIN THERAPY FOR TREATMENT OF RETINAL DISEASES
#2289Methods of promoting angiogenesis in tissue with fibromodulin
#2290Pharmaceutical composition for treating bone diseases which comprises protein comprising Frizzled 1, Frizzled 2 or Frizzled 7 extracellular cysteine-rich domain
#2291Modified colostrum protein and application thereof
#2292ALZHEIMER'S DISEASE TREATMENT METHOD
#2293Protease-engineered Cancer Cell Spheres as an Immunotherapy to Treat Cancer and non-Cancer Diseases
#2294METHODS FOR DIAGNOSING, PROGNOSING AND TREATING MUSCULAR DYSTROPHY
#2295DPEP-1 binding compositions and methods of use
#2296METHOD OF USE OF ACTIVATED FUNCTIONAL PROTEINS TO IMPROVE ANIMAL HEALTH
#2297Medicament for Atrophy Treatment or Increasing Cell Growth
#2298Nutritive fragments, proteins and methods
#2299METHODS FOR TREATING TISSUE DAMAGE ASSOCIATED WITH ISCHEMIA WITH APOLIPOPROTEIN D
#2300Systems and methods for attracting and trapping brain cancer cells
#2301STAPLED INTRACELLULAR-TARGETING ANTIMICROBIAL PEPTIDES TO TREAT INFECTION
#2302T-cell redirecting bispecific antibodies for treatment of disease
#2303Guided injections for AAV gene transfer to muscle
#2304METHODS OF TREATING OR PREVENTING PERIODONTITIS AND DISEASES ASSOCIATED WITH PERIODONTITIS
#2305Oligopeptidic compounds and uses thereof
#2306Use Of SCO-Spondin Peptides For Inhibiting Or Preventing Neuronal Apoptosis Mediated By Cell Death Receptor Ligands
#2307Compositions and methods for inhibiting intercellular interactions
#2308PREDICTING AMD WITH SNPS WITHIN OR NEAR C2, FACTOR B, PLEKHA1, HTRA1, PRELP, OR LOC387715
#2309Selective recovery
#2310Compositions and methods for inhibiting tumor cells by inhibiting the transcription factor ATF5
#2311Compositions and methods for inhibiting tumor cells by inhibiting the transcription factor ATF5
#2312Generating GABAergic neurons in brains
#2313FORMULATIONS FOR HISTATIN PROTECTIVES AND THERAPEUTICS
#2314FORMULATIONS FOR HISTATIN THERAPEUTICS
#2315THERAPEUTIC COMPOSITION COMPRISING ANNEXIN V
#2316Pathogenic control of apoptosis
#2317RTEF-1 VARIANTS AND USES THEREOF
#2318CYCLIC POLYPEPTIDES FOR THE TREATMENT OF HEART FAILURE
#2319Peptidylic inhibitors of nucleolin (NCL) targeting CAG-repeat RNA toxicity and methods for reducing polyQ-mediated toxicity in polyQ diseases
#2320Method for separating proteins from animal or human plasma, or plants, using a pH gradient method
#2321Methods for treatment of and prophylaxis against inflammatory disorders
#2322Mannose-6-phosphate bearing peptides fused to lysosomal enzymes
#2323FORMULATIONS FOR HISTATIN THERAPEUTICS
#2324USES OF CASEIN COMPOSITIONS
#2325POLYPEPTIDES AND USES THEREOF AS A DRUG FOR TREATMENT OF MULTIPLE SCLEROSIS, RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISORDERS
#2326Cell-permeable (ICP)-SOCS3 recombinant protein and uses thereof
#2327GENOME EDITING FOR THE TREATMENT OF HUNTINGTON'S DISEASE
#2328Methods for diagnosing and treating Alzheimer's disease
#2329HISTATINS AS THERAPEUTIC AGENTS FOR OCULAR SURFACE DISEASE
#2330Methods for preventing or treating disorders by increasing bioavailability of iron and related pharmaceutical formulation
#2331Pharmaceutical composition for suppressing cell transplant rejection
#2332Engraftment of stem cells with a combination of an agent that targets stem cells and modulation of immunoregulatory signaling
#2333Therapeutic nanoparticles having EGFR ligands and methods of making and using same
#2334Methods and kits for monitoring membranous nephropathy
#2335Compositions and methods for treatment of muscular dystrophy
#2336INTRATHECAL DELIVERY OF RECOMBINANT ADENO-ASSOCIATED VIRUS 9
#2337Process for producing a composition for increasing muscle mass
#2338Recombinant adeno-associated virus delivery of alpha-sarcoglycan polynucleotides
#2339PAX6 minipromoters
#2340ApoE mimetic peptides and higher potency to clear plasma cholesterol
#2341SOCS1-derived peptide for use in chronic complications of diabetes
#2342Phosphoserine containing compositions for immune tolerance induction
#2343Use of HDL-related molecules to treat and prevent proinflammatory conditions
#2344PEPTIDE-BASED STAT INHIBITOR
#2345Use of annexin v as a method to block tumor induced immunosuppression of the innate immune response
#2346OPTOGENETIC CONTROL OF INPUTS TO THE VENTRAL TEGMENTAL AREA
#2347DIFFERENTIATION MARKER AND DIFFERENTIATION CONTROL OF EYE CELL
#2348Method of promoting wound healing
#2349CONFIGURABLE CLATHRIN LIGHT CHAIN COMPOSITION
#2350METHODS FOR TREATING CANCER WITH ANTI BIP OR ANTI MICA ANTIBODIES
#2351METHODS FOR REPAIRING CARTILAGE DAMAGE
#2352Reconstituted high density lipoprotein formulation and production method thereof
#2353Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof
#2354Recombinant AAVS having useful transcytosis properties
#2355Cell-permeable (iCP)-SOCS3 recombinant protein and uses thereof
#2356Diagnostic and therapeutic uses of gelsolin in renal failure
#2357Mutant NGAL proteins and uses thereof
#2358Use of peptides that block metadherin-SND1 interaction as treatment for cancer
#2359Medical agents and uses thereof
#2360Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
#2361WOUND-HEALING-ENHANCING DEVICES
#2362Charged lipoprotein complexes and their uses
#2363Method of preventing polycystic kidney disease and PKD animal model with exogenous neutrophil gelatinase-associated lipocalin
#2364Compositions and methods for modulating NCOA4-mediated autophagic targeting of ferritin
#2365APPETITE-SUPPRESSING AGENT
#2366Compositions and methods for treating eye infections and disease
#2367Methods and Apparatus for Creating Particle Derivatives of HDL with Reduced Lipid Content
#2368Gene therapy for retinitis pigmentosa
#2369NOVEL BINDING PROTEINS FOR PCSK9
#2370Semaphorin 3C variants, compositions comprising said variants and methods of use thereof in treating eye diseases
#2371Method of ex vivo enhancement of immune cell activity for cancer immunotherapy with a small molecule ablative compound
#2372Targeting peptides for directing adeno-associated viruses (AAVs)
#2373Recombinant AAV vectors useful for reducing immunity against transgene products
#2374CLATHRIN REPLACEMENT THERAPEUTICS
#2375Pharmaceutical compositions for treating or preventing bone conditions
#2376PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND THEIR USES IN DISEASE
#2377COMPOSITION OF LIPID-BASED NANOPARTICLES FOR SMALL MOLECULES AND MACROMOLECULES
#2378Method and composition for inducing human pluripotent stem cells
#2379MODULATING DISEASE THROUGH GENETIC ENGINEERING OF PLANTS
#2380Mimotopes of alpha-synuclein and vaccines thereof for the treatment of neurodegenerative disorders
#2381CDK MODULATORS AND METHODS FOR THE TREATMENT OF CANCER
#2382Trefoil family factor proteins and uses thereof
#2383CAPCNA peptide therapeutics for cancer
#2384Prescription of intravenous medication for blocking heroin or morphine intoxication path and using thereof
#2385Compositions and methods for disease treatment using nanoparticle delivered compounds
#2386Fermented infant formula with non digestible oligosaccharides
#2387Flattop (FLTP) is a novel biomarker for beta cell maturation
#2388MECP2E1 GENE
#2389COMPOSITIONS FOR THE TREATMENT OF WOUNDS
#2390Particles comprising protamine and RNA in combination with endosome destabilizing agents
#2391Methods for treating cancer with EGFR nanobodies linked to DR5 binding moieties
#2392Peptide and uses therefor
#2393METHODS AND COMPOSITIONS OF CHONDRISOMES
#2394Method for stem cell differentiation in vivo by delivery of morphogenes with mesoporous silica and corresponding pharmaceutical active ingredients
#2395Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
#2396Methods for treating neurological conditions and compositions and materials therefor
#2397Use of exosomes to promote or enhance hair growth
#2398Natriuretic polypeptides
#2399Annexin II compositions
#2400Treating rotator cuff conditions