ALLOSTERIC MODULATION OF MUSCARINIC ACETYLCHOLINE RECEPTOR EFFICACY

COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR

HERBICIDAL QUINOLONE DERIVATIVES

DEUTERATED CFTR POTENTIATORS

QUINOLINE CARBOXYLIC ACID ESTER COMPOUND AND PREPARATION METHOD AND USE THEREOF

PHARMACEUTICAL COMPOSITION AND ADMINISTRATIONS THEREOF

STABLE CRYSTAL OF 4-OXOQUINOLINE COMPOUND

COMPOUNDS FOR TREATMENT OF CANCER

COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR

A QUINOLONE COMPOUND IN SOLID FORMS AND PROCESSES FOR THE PREPARATION THEREOF

PROCESS FOR THE PREPARATION OF IVACAFTOR AND NOVEL SOLVATES THEREOF

POLYSUBSTITUTED NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES, PREPARATION METHOD AND USE THEREOF

Processes for making modulators of cystic fibrosis transmembrane conductance regulator

Pharmaceutical composition and administrations thereof

COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR

SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE

5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-QUINOLINE-3-CARBOXAMIDE POTASSIUM SALT FOR TREATING INFLAMMATORY BOWEL DISEASES

4-OXOQUINOLINE COMPOUND AND USE THEREOF AS PHARMACEUTICAL AGENT

INHIBITORS OF MICROBIALLY INDUCED AMYLOID

INHIBITORS OF MICROBIALLY INDUCED AMYLOID

QUINOLIN-4-ONE AND 4(1H)-CINNOLINONE COMPOUNDS AND METHODS OF USING SAME

Compositions, methods and kits for treating a contact lens

Imino sulfanone inhibitors of ENPP1

CRYSTAL FORM OF QUINOLINONE COMPOUND AND USE THEREOF

TARGETING PTPN22 IN CANCER THERAPY

Pharmaceutical composition and administrations thereof

STABLE CRYSTAL OF 4-OXOQUINOLINE COMPOUND

QUINOLINE CARBOXYLATE COMPOUND AND PREPARATION METHOD AND USE THEREOF

Crystalline form of ivacaftor and a process for preparing the same

DNA2 inhibitors for cancer treatment

DEUTERATED CFTR POTENTIATORS

Lymphoid-specific tyrosine phosphatase (LYP) inhibitors

INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY

Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases

Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Quinolone derivatives, preparation methods and application thereof

Method for the hydrolysis of quinolonecarboxylic esters

Compounds, compositions, and methods for modulating CFTR

QUINOLONE COMPOUND

Process for the preparation of ivacaftor and its intermediates

ADMINISTRATION OF DEUTERATED CFTR POTENTIATORS

Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Process for the synthesis of ivacaftor

Process for preparing antihelmintic 4-amino-quinoline-3-carboxamide derivatives

Processes for making modulators of cystic fibrosis transmembrane conductance regulator

Deuterated CFTR potentiators

Inhibitors of microbially induced amyloid

DNA2 inhibitors for cancer treatment

ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS

Streamlined syntheses of fluoroquinolones

4-OXOQUINOLINE COMPOUND AND USE THEREOF AS PHARMACEUTICAL AGENT

Quinolone-based compounds with anticancer activity

QUINOLONE COMPOUND

Deuterated CFTR potentiators

Process for the preparation of quinolone based compounds

Process for the preparation of ivacaftor

Pyridonecarboxylic acid derivative or salt thereof

Pharmaceutical composition and administrations thereof

STABLE CRYSTAL OF 4-OXOQUINOLINE COMPOUND

Deuterated CFTR potentiators

Compounds, compositions, and methods for modulating CFTR

Modulators of ATP-binding cassette transporters

Compositions, methods and kits for treating a contact lens

Multi-tiered high through-put screen for compounds effective against bacterial biofilm and compounds effective for inhibiting and eradicating bacterial biofilm

Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases

DNA2 inhibitors for cancer treatment

QUINOLONE COMPOUND

Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Core-shell structure supported tungsten composite catalyst and preparation method and use thereof

Monocarboxylate transport modulators and uses thereof

Method for Producing 4-Oxoquinoline Compound

Oxy-cyanoquinolinone PDE9 inhibitors

Processes for the preparation of ivacaftor

5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE, SALTS AND USES THEREOF

DNA2 inhibitors for cancer treatment

Process for the synthesis of ivacaftor and related compounds

Deuterated CFTR potentiators

STABLE CRYSTAL OF 4-OXOQUINOLINE COMPOUND

QUINOLONE COMPOUND

Polymorphs of Ivacaftor, process for its preparation and pharmaceutical composition thereof

CRYSTALS OF LAQUINIMOD SODIUM AND IMPROVED PROCESS FOR THE MANUFACTURE THEREOF

USE OF LAQUINIMOD FOR TREATING CROHN'S DISEASE PATIENTS WHO FAILED FIRST-LINE ANTI-TNF THERAPY

Quinolinone compound and use thereof

Inhibitors of HIF prolyl hydroxylase

DNA2 inhibitors for cancer treatment

4-OXO-1, 4-DIHYDROQUINOLINE-3-CARBOXAMIDE AS SELECTIVE LIGAND FOR CANNABINOID RECEPTOR 2 FOR DIAGNOSIS AND THERAPY

METHODS FOR INDUCING INSULIN PRODUCTION AND USES THEREOF

DEUTERATED CFTR POTENTIATORS

Pharmaceutical composition and administrations thereof

Industrial process for making an Ivacaftor and its intermediates

Process for making modulators of cystic fibrosis transmembrane conductance regulator

Agents for use in the treatment of cardiovascular and inflammatory diseases structurally based on 4(1 H)-quinolone

Compositions and methods of inhibiting histone deacetylases

PQSR modulators

Reduction-triggered antibacterial sideromycins

R-7-(3-aminomethyl-4-methoxyimino-3-methyl-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-acid and L-aspartic acid salt, process for the preparation thereof and pharmaceutical composition comprising the same for antimicrobial

QUINOLONE COMPOUND

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

Solid forms of Ivacaftor and processes for the preparation thereof

5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE, SALTS AND USES THEREOF

Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

Pharmaceutical Compositions for the Treatment of CFTR-Mediated Disorders

T-box riboswitch-binding anti-bacterial compounds

Heterocyclic GSK-3 allosteric modulators

Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator

CRYSTALS OF LAQUINIMOD SODIUM AND IMPROVED PROCESS FOR THE MANUFACTURE THEREOF

Deuterated CFTR potentiators

Multi-tiered, high through-put screen for compounds effective against bacterial biofilm compounds effective for inhibiting and eradicating bacterial biofilm

Process for the preparation of Ivacaftor and its intermediates

Process for the preparation of ivacaftor and solvates thereof

STABLE CRYSTAL OF 4-OXOQUINOLINE COMPOUND

Prodrugs of Modulators of ABC Transporters

Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

Pharmaceutical Compositions for the Treatment of CFTR-Mediated Disorders

PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

AMPK Modulators

Quinolone compound

Partially saturated nitrogen-containing heterocyclic compound

Heterocyclic compound and use therefor

Deuterated CFTR potentiators

NOVEL BIFUNCTIONAL METNASE/INTNASE INHIBITORS AND RELATED COMPOSITIONS AND METHODS OF TREATMENT OF CANCER

PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR-MEDIATED DISORDERS

Process for making modulators of cystic fibrosis transmembrane conductance regulator

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

MIF inhibitors and their uses

Heterocyclic GSK-3 allosteric modulators

QUINOLONE COMPOUND

Modulators of ATP-binding cassette transporters

Deuterated N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof

SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE

MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

Crystals of laquinimod sodium and improved process for the manufacture thereof

PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

Antibiotic conjugates directly linked with steroid drugs

Pharmaceutical composition and administrations thereof

PRODRUGS OF MODULATORS OF ABC TRANSPORTERS

Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

2-hydroxyarylamide derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating cancer containing same as active ingredient

TREATMENT OF CROHN'S DISEASE WITH LAQUINIMOD

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

Quinolone compound

CRYSTALS OF LAQUINIMOD SODIUM, AND PROCESS FOR THE MANUFACTURE THEREOF

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Amine salts of laquinimod

Deuterium-enriched 4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide

Solid forms of antibiotics

Substituted 2-oxy-quinoline-3-carboxamides as KCNQ2/3 modulators

Deuterated CFTR potentiators

ANTIVIRAL AND ANTIMICROBIAL COMPOUNDS

DEUTERATED N-ETHYL-N-PHENYL-1,2-DIHYDRO-4-HYDROXY-5-CHLORO-1-METHYL-2-OXOQUINOLINE-3-CARBOXAMIDE, SALTS AND USES THEREOF

Biodegradable polymer—bioactive moiety conjugates

Process and intermediates for preparing integrase inhibitors

Process for making modulators of cystic fibrosis transmembrane conductance regulator

Process for preparing quinoline-3-carboxamide derivatives

N-ethyl-4-hydroxyl-1-methyl-5-(methyl(2,3,4,5,6-pentahydroxyhexyl)amino)-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Modulators of cystic fibrosis transmembrane conductance regulator

Prodrugs of Modulators of ABC Transporters

Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Haptens and immunoreactive agents and use thereof for producing family antibodies and immunoassays for quinolones

Quinolinone derivatives

Process and intermediates for preparing integrase inhibitors

Heterocyclic derivative and pharmaceutical composition comprising the same

N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide, preparation and uses thereof

1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as AHR activators

4-OXOQUINOLINE COMPOUND AND USE THEREOF AS HIV INTEGRASE INHIBITOR

Modulators of ATP-binding cassette transporters

4(1H)-quinolones having antimalarial activity with reduced chemical resistance

Process and intermediates for preparing integrase inhibitors

Method for manufacturing of quinoline-3-carboxamides

Solid forms of N-[2,4-Bis(1,1-dimethyethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquioline-3-carboxamide

Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Process for making modulators of cystic fibrosis transmembrane conductance regulator

Modulators of ATP-binding cassette transporters

Solid Forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Modulators of ATP-Binding Cassette transporters

Bifunctional metnase/intnase inhibitors and related compositions and methods of treatment of cancer

AMPK modulators

Process and intermediates for preparing integrase inhibitors

Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Modulators of cystic fibrosis transmembrane conductance regulator

Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Quinolone derivative or pharmaceutically acceptable salt thereof

R-7-(3-aminomethyl-4-methoxyimino-3-methyl-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid and L-aspartic acid salt, process for the preparation thereof and pharmaceutical composition comprising the same for antimicrobial

PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

Substituted heterocyclic compounds as kinases inhibitors and methods of use thereof

Modulators of cystic fibrosis transmembrane conductance regulator

Substituted 2-oxy-quinoline-3-carboxamides as KCNQ2/3 modulators

TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION

Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation

5-CHLORO-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE, SALTS AND USES THEREOF

Deuterated N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof

HIGHLY PURE LAQUINIMOD OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

NOVEL COMPOSITIONS AND METHODS OF USE

Preparation methods of 6 substituted amino-3 cyanoquinoline compounds and the intermediates thereof

Biodegradable polymer—bioactive moiety conjugates

Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Methods of enhancing sweet taste of compositions using substituted thieno{2,3-D}pyrimidines

Solid state forms of laquinimod and its sodium salt

NOVEL COMPOSITIONS AND METHODS OF USE

Process and intermediates for preparing integrase inhibitors

N-heterocyclic M1 receptor positive allosteric modulators

Process for preparing modulators of cystic fibrosis transmembrane conductance regulator

Crystals of laquinimod sodium, and process for the manufacture thereof

Crystals of laquinimod sodium, and process for the manufacture thereof

Process for preparing quinoline-3-carboxamide derivatives

Solid forms of N-[2,4-BIS(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Treatment of Crohn's disease with laquinimod

ENROFLOXACIN HEXAHYDRATE

Fused pyridone M1 receptor positive allosteric modulators

Quinolone M1 receptor positive allosteric modulators

Process and intermediates for preparing integrase inhibitors

KYNURENINE-AMINOTRANSFERASE INHIBITORS

Process for making modulators of cystic fibrosis transmembrane conductance regulator

Compositions and methods for apoptosis modulators

Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof

PRODRUG DERIVATIVES OF ACIDS USING ALCOHOLS WITH HOMOTOPIC HYDROXY GROUPS AND METHODS FOR THEIR PREPARATION AND USE

METHOD FOR SALT PREPARATION

Stable crystal of 4-oxoquinoline compound

PROCESS FOR THE PREPARATION AND PHARMACEUTICAL FORMULATIONS FOR 4-QUINOLINONES AND QUINOLINES AND USE THEREOF

Quinolone based compounds exhibiting, prolyl hydroxylase inhibitory activity, and compositions, and uses thereof

Modulators of ATP-binding cassette transporters

STEREOSELECTIVE SYNTHESIS OF PIPERIDINE DERIVATIVES

Solid forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluorormethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihyroquinoline-3-carboxamide

Modulators of cystic fibrosis transmembrane conductance regulator

Method for producing quinolone carboxylic acid derivative

LABELLED ANALOGUES OF HALOBENZAMIDES AS RADIOPHARMACEUTICALS

2-oxo-1,2-dihydro-quinoline modulators of immune function

AMPK modulators

Benzyl-substituted quinolone M1 receptor positive allosteric modulators

Process for production of 4-oxoquinoline compound

Modulators of ATP-binding cassette transporters

Crystalline salts of quinoline compounds and methods for preparing them

Modulators of ATP-binding cassette transporters

Quinolone derivative or pharmaceutically acceptable salt thereof

4-oxoquinoline derivatives

Quinolone derivative or salt thereof

MAPK/ERK kinase inhibitors

Prodrugs of modulators of ABC transporters

PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS

Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxypheny1]-1,4-dihydro-4-oxoquinoline-3-carboxamide

DEUTERIUM-ENRICHED CIPROFLOXACIN

Method for producing 4-oxoquinoline compound

USE OF 6-(3-CHLORO-2-FLUOROBENZYL)-1-[(2S)-1-HYDROXY-3-METHYLBUTAN-2-YL]-7-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID OR SALT THEREOF FOR TREATING RETROVIRUS INFECTION

Nitric Oxide Enhancing Antimicrobial Compounds, Compositions and Methods of Use

Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors

ANHYDROUS CIPROFLOXACIN HYDROCHLORIDE

Novel crystalline forms of gatifloxacin

Substituted quinolones II

Compounds that inhibit cholinesterase

6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor

Novel synthesis of gatifloxacin

Monomer with anti-microbial character, polymer using the same, and manufacturing method thereof

Substituted Quinolone Carboxylic Acids, Their Derivatives, Site of Action, And Uses Thereof

Process for the synthesis of 6-amino-4-(3-chloro-4-fluorophenylamino)-7-ethoxyquinoline-3-carbonitrile

Triazolo-quinolin derivatives useful as adenosine receptor ligands

Novel quinoline derivatives

Process and intermediates for preparing integrase inhibitors

Crystalline forms of Gatifloxacin

Modulators of ATP-binding cassette transporters

4-substituted quinolines as antitumor agents

N-Acylated lipophilic amino acid derivatives

Substituted quinolones

Method of preparing 4-halogenated quinoline intermediates

Targeted Drug-Formaldehyde Conjugates and Methods of Making and Using the Same

Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use

Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity

Processes for producing 7-isoindoline-quinolonecarboxylic acid derivative and its intermediate, as well as salt of 7-isoindoline-quinolonecarboxylic acid derivative, its hydrate and composition comprising the same as active ingredient

Process for the synthesis of N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids

Quinolin-4-ones as inhibitors of retroviral integrase for the treatment of HIV, AIDS and AIDS related complex (ARC)

Quinolone Carboxylic Acid Derivatives for Treatment of Hyperproliferative Conditions

N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives

Process for the preparation of the boron difluoride chelate of quinolone-3-carboxylic acid

Methods of synthesizing radiolabeled 3-cyano[14C]quinolines

Cyclic compounds

Novel antibacterial agents

Crystals of laquinimod sodium, and process for the manufacture thereof

Novel synthesis of gatifloxacin

Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents

Antiviral agents

Crystalline form of gatifloxacin

Substituted quinolines as antitumor agents

Methods of synthesizing substituted 3-cyanoquinolines and intermediates thereof

Novel crystalline forms of gatifloxacin and processes for preparation

Novel crystalline forms of gatofloxacin and processes for preparation

Novel crystalline forms of gatifloxacin and processes for preparation

Novel crystalline forms of gatifloxacin and processes for preparation

Novel crystalline forms of gatifloxacin and processes for preparation

Novel crystalline forms of gatifloxacin and processes for preparation

Tricyclic protein kinase inhibitors

4-oxoquinoline compound and use thereof as HIV integrase inhibitor

Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof

Novel 4-anilinoquinoline-3-carboxamides

Quinolone derivative or salt thereof

Anhydrous crystalline forms of I and II of 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1- piperazinyl) 4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (gatifloxacin)

Amide derivatives