109047 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof General methods applicable to biologically active non-coding nucleic acids
siRNA targeting superoxide dismutase 1 (SOD1)
#4502siRNA targeting fructose-1,6-bisphosphatase 1 (FBP1)
#4503siRNA targeting amyloid beta (A4) precursor protein (APP)
#4504siRNA targeting glucagon receptor (GCGR)
#4505siRNA targeting beta secretase (BACE)
#4506siRNA targeting apolipoprotein B (APOB)
#4507siRNA targeting diacylglycerol O-acyltransferase homolog 2 (DGAT2)
#4508Polynucleotides for causing RNA interference and method for inhibiting gene expression using the same
#4509RECOMBINANT EUKARYOTIC CELLS STABLY EXPRESSING (SID-1) PROTEINS FOR HIGH THROUGHPUT GENE SCREENING
#4510CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY
#4511Functional and hyperfunctional siRNA directed against Bcl-2
#4512Functional and hyperfunctional siRNA directed against Bcl-2
#4513Peptide Nucleic Acid Conjugates and Uses Thereof
#4514siRNA targeting kinases
#4515siRNA targeting TNFalpha
#4516Functional and hyperfunctional siRNA directed against Bcl-2
#4517siRNA targeting deubiqutination enzymes
#4518Small Interfering Rna and Pharmaceutical Composition for Treatment of Hepatitis B Comprising the Same
#4519Functional and hyperfunctional siRNA directed against Bcl-2
#4520Functional and hyperfunctional siRNA directed against Bcl-2
#4521Functional and hyperfunctional siRNA directed against Bcl-2
#4522Functional and hyperfunctional siRNA directed against Bcl-2
#4523siRNA targeting complement component 3 (C3)
#4524siRNA targeting secreted frizzled-related protein 1 (sFRP1)
#4525SiRNA targeting intercellular adhesion molecule 1 (ICAM1)
#4526MODULATION OF GENE EXPRESSION USING DNA-RNA HYBRIDS
#4527siRNA targeting transient receptor potential cation channel, subfamily V, member 1 (TRPV1)
#4528siRNA targeting phosphoinositide-3-kinase, class 2, beta polypeptide (PIK3C2B)
#4529Duplex oligonucleotide complexes and methods for gene silencing by RNA interference
#4530VEHICLE FOR THE TRANSPORT OF A CHOSEN MOLECULE TO A CELL
#4531siRNA targeting carbonic anhydrase 4(CA4)
#4532Methods and compositions for inhibiting the function of polynucleotide sequences
#4533Methods of using combinations of siRNAs for treating a disease or a disorder, and for enhancing siRNA efficacy in RNAi
#4534siRNA targeting nuclear receptors
#4535DICER SUBSTRATE RNA PEPTIDE CONJUGATES AND METHODS FOR RNA THERAPEUTICS
#4536siRNA targeting proteasome 26S subunit, non-ATPase, 10 (Gankyrin or PSMD10)
#4537siRNA targeting ubiquitin ligases
#4538Cytoplasmic Localization Dna and Rna
#4539RNA interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by DNA and transfected dendritic cell vaccines
#4540siRNA targeting cyclin dependent kinase 11 (CDK11)
#4541Conjugate of Peo and Double Stranded Nucleic Acid
#4542pRNA chimera
#4543Methods and compositions for amplification and detection of MicroRNAs
#4544Methods and compositions involving miRNA and miRNA inhibitor molecules
#4545siRNA targeting platelet-derived growth factor receptor beta polypeptide (PDGFR)
#4546Three-component biosensors for detecting macromolecules and other analytes
#4547POLYCYCLIC SUGAR SURROGATE-CONTAINING OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATION
#4548siRNA targeting neuropeptide Y (NPY)
#4549RETROGRADE TRANSPORT OF SIRNA AND THERAPEUTIC USES TO TREAT NEUROLOGIC DISORDERS
#4550Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes
#4551Polycationic compositions for cellular delivery of polynucleotides
#45522'-MODIFIED OLIGONUCLEOTIDES
#4553RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)
#4554siRNA targeting sodium channel, voltage-gated, type X, alpha (SCN10A)
#4555siRNA targeting vascular endothelial growth factor (VEGF)
#4556Methods and compositions involving microRNA
#4557Cell-based RNA interference and related methods and compositions
#4558Methods and Compositions for Use in Preparing Hairpin Rnas
#4559siRNA targeting connective tissue growth factor (CTGF)
#4560Cochleate compositions directed against expression of proteins
#4561Methods, libraries and computer program products for determining whether siRNA induced phenotypes are due to off-target effects
#4562Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
#4563Method for manufacturing specific binding molecules against selected target molecules, kit, and binding molecules
#4564siRNA targeting vacuolar ATPase
#4565MicroRNA biomarkers for human breast and lung cancer
#4566BACKBONE MODIFICATIONS TO MODULATE OLIGONUCLEOTIDE TARGETING IN VIVO
#4567Cancer Therapeutic
#4568Delivering functional nucleic acids to mammalian cells via bacterially-derived, intact minicells
#4569siRNA targeting minichromosome maintenance deficient 5 (MCM5)
#4570COMPLEXES AND METHODS OF FORMING COMPLEXES OF RIBONUCLEIC ACIDS AND PEPTIDES
#4571Agents, compositions and methods for treating pathologies in which regulating an ache-associated biological pathway is beneficial
#4572siRNA targeting minichromosome maintenance deficient 6 (MCM6)
#4573SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof
#4574COMPOSITIONS AND METHODS FOR LIPID AND POLYPEPTIDE BASED siRNA INTRACELLULAR DELIVERY
#4575Kits and methods for generating 5' capped RNA
#4576siRNA targeting serine/threonine kinase 12 (STK12 or aurora B kinase)
#4577siRNA targeting dual specificity phosphate 5 (DUSP5)
#4578CATIONIC PEPTIDES FOR siRNA INTRACELLULAR DELIVERY
#4579RNA amidates and thioamidates for RNAi
#4580Therapeutic compositions
#4581Double-stranded ribonucleic acid with increased effectiveness in an organism
#4582MicroRNA motifs
#4583Oligonucleotide and the use thereof for modulating an isoform C beta-1 protein-kinase in the form of a skin depigmentation agent
#4584Rybozyme-catalyzed insertion of targeted sequences into RNA
#4585FORMULATIONS FOR INTRACELLULAR DELIVERY dsRNA
#4586Stabilized siRNAs as transfection controls and silencing reagents
#4587Multitargeting interfering RNAs having two active strands and methods for their design and use
#4588Transcatheter tumor immunoembolization
#4589siRNA targeting polo-like kinase-1 (PLK-1)
#4590siRNA targeting testes development-related NYD-SP21 (NYD-SP21)
#4591Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#4592Antisense restenosis composition and method
#4593siRNA targeting RAD1 homolog (RAD1)
#4594siRNA targeting pituitary tumor-transforming 1 (PTTG1)
#4595siRNA targeting minichromosome maintenance deficient 7 (MCM7)
#4596siRNA targeting MAD2 mitotic arrest deficient-like (MAD2L2)
#4597siRNA targeting centromere protein E, 312kDa (CENPE)
#4598siRNA targeting EPH receptor A4 (EPHA4)
#4599Antisense agents combining strongly bound base-modified oligonucleotide and artificial nuclease
#4600Compositions and methods for enhancing discriminatory RNA interference
#4601SELECTING AND STABILIZING dsRNA CONSTRUCTS
#4602Anti-Tumor Activity of an Oncolytic Adenovirus-Delivered Oncogene siRNA
#4603siRNA targeting v-myc myelocytomatosis viral oncogene homolog (MYC)
#4604siRNA targeting serine/threonine kinase 22B (STK22B)
#4605siRNA targeting minichromosome maintenance deficient 2, mitotin (MCM2)
#4606siRNA targeting EPH receptor A3 (EPHA3)
#4607siRNA targeting discoidin domain receptor family, member 1 (DDR1)
#4608siRNA targeting cell division cycle 6 homolog (CDC6)
#4609siRNA targeting spectrin SH3 domain binding protein 1 (SSH3BP1)
#4610COMPOSITIONS AND METHODS EMPLOYING UNIVERSAL-BINDING NUCLEOTIDES FOR TARGETING MULTIPLE GENE VARIANTS WITH A SINGLE siRNA DUPLEX
#4611Activatable Ribozymal Purification Constructs and Methods of Use
#4612siRNA targeting WEE1 homolog (WEE1)
#4613Modulation of immune response and inflammation by targeting hypoxia inducible factors
#4614Soluble TNF receptors and their use in treatment of disease
#4615Compositions and methods for altering RNAi
#4616Arrays containing cleavable RNAi molecules
#4617Individualized cancer therapy
#4618siRNA targeting phosphoinositide-3-kinase, class 2, alpha polypeptide (PIK3C2A)
#4619siRNA targeting coatomer protein complex, subunit beta 2 (COPB2)
#4620Antisense compounds targeted to connexins and methods of use thereof
#4621Biodegradable cationic polymers
#4622siRNA targeting chemokine (C-X-C motif) receptor 4 (CXCR4)
#4623Methods and compositions for inhibiting the function of polynucleotide sequences
#4624siRNA targeting cell division cycle 2-like 5(CDC2L5)
#4625Methods and compositions for inhibiting the function of polynucleotide sequences
#4626METHODS FOR DIRECTING DNA METHYLATION IN MAMMALIAN CELLS USING HOMOLOGOUS, SHORT DOUBLE STRANDED RNAS
#4627Multicomponent nucleic acid enzymes and methods for their use
#4628Method for preparing short hairpin RNA from CDNA
#4629CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY
#4630siRNA targeting gremlin
#4631Vehicle for the Transport of a Chosen Molecule to a Cell
#4632VEHICLE TO TRANSPORT A DNA-MODIFYING ENZYME TO A GENOME
#4633Protection of Biologically Active Molecules Using Amphiphiles
#4634siRNA targeting azurocidin 1 (Cartionic Antimicrobial protein 37)
#4635Methods and compositions for inhibiting the function of polynucleotide sequences
#4636Modified triple-helix forming oligonucleotides for targeted mutagenesis
#4637Polypeptide Having Rnase III Activity
#4638Methods, libraries and computer program products for gene silencing with reduced off-target effects
#4639Method for identifying drug-sensitizing antisense DNA fragments and use thereof
#4640MicroRNA precursors
#4641METHOD TO INDUCE RNAI IN PROKARYOTIC ORGANISMS
#4642siRNA targeting cell division cycle 25 (CDC25C)
#4643siRNA targeting calcium/calmodulin dependent protein kinase IV (CAMK4)
#4644Method of selecting targets for gene silencing by RNA interference
#4645Functional and hyperfunctional siRNA
#4646siRNA targeting minichromosome maintenance deficient 4 (MCM4)
#4647Interfering Rna Duplex Having Blunt-Ends And 3'-Modifications
#4648Promoters for RNA interference
#4649Data correction apparatus, data correction method, magnetic resonance imaging apparatus and X-ray CT apparatus
#4650Pharmaceutical composition
#4651Short interfering RNA (siRNA) analogues
#4652siRNA targeting cell division cycle 20 homolog (CDC20)
#4653siRNA targeting insulin-like growth factor 1 receptor (IGF-1R)
#4654siRNA targeting connexin 43
#4655siRNA targeting HtrA serine peptidase 1
#4656DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#4657DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#4658Rna interference mediated inhibition of nogo and nogo receptor gene expression using short interfering nucleic acid (sina)
#4659Methods, agents, and compound screening assays for inducing differentiation of undifferentiatied mammalian cells into osteoblasts
#4660siRNA targeting testis-specific serine kinase 4
#4661DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#4662DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#4663DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#4664DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#4665Protected monomers
#4666MODIFIED POLYNUCLEOTIDES FOR USE IN RNA INTERFERENCE
#4667DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#4668DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#4669DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#4670DRY POWDER COMPOSITIONS FOR RNA INFLUENZA THERAPEUTICS
#4671RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4672DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#4673DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#4674DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#4675Compositions, devices and methods for treatment of huntington's disease through intracranial delivery of sirna
#4676Modified polynucleotides for use in rna interference
#4677DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#4678MICRORNAS AND RELATED NUCLEIC ACIDS
#4679Small interfering RNA libraries and methods of synthesis and use
#4680Method for evaluating rnai activity and mirna activity
#4681RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER'S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA)
#4682Methods and compositions for treating neurological disease
#4683Methods and sequences to preferentially suppress expression of mutated huntingtin
#4684Methods and compositions involving microRNA
#4685Compositions and methods for generating short double-stranded RNA using mutated RNAse III
#4686System and method for identification of MicroRNA target sites and corresponding targeting MicroRNA sequences
#4687siRNA targeting spleen tyrosine kinase
#4688siRNA targeting aquaporin 4
#4689siRNA targeting cAMP-specific phosphodiesterase 4D
#4690Method of producing short hairpin library
#4691Shielded micelles for polynucleotide delivery
#4692Modified siRNA molecules and uses thereof
#4693Methods of modulating angiogenesis and screening compounds for activity in modulating angiogenesis
#4694Antisense antibacterial method and compound
#4695siRNA targeting histamine receptor H1
#4696siRNA targeting TIE-2
#4697siRNA targeting hypoxia-inducible factor 1
#4698siRNA targeting ras-related nuclear protein
#4699Inhibition of gene expression by delivery of polynucleotides to animal cells in vivo
#4700Universal target sequences for siRNA gene silencing
#4701DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#4702Replication competent viruses capable of silencing virus inhibitory factor expression
#4703Gene blocking method
#4704Modulation of gene expression by oligomers targeted to chromosomal DNA
#4705RNA interference
#4706Small regulatory RNAs and methods of use
#4707Splice switch oligomers for TNF superfamily receptors and their use in treatment of disease
#4708Methods and compositions for treating neurological disease
#4709Gene expression suppression agents
#4710Polynucleotides capable of target-depedent circularization and topological linkage
#4711Small interfering RNA mediated transcriptional gene silencing in mammalian cells
#4712siRNA targeting carbonic anhydrase II
#4713Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mRNAs
#4714Nanoparticle delivery systems and methods of use thereof
#4715siRNA targeting MCL1
#4716RNA interference mediating small RNA molecules
#4717Use of eukaryotic genes affecting spindle formation or microtubule function during cell division for diagnosis and treatment of proliferative diseases
#4718Rna interference mediated inhibition of xiap gene expression using short interfering nucleic acid (sina)
#4719Method for changing genetic properties of eukaryotic organism
#4720siRNA targeting tumor necrosis factor superfamily member 1A
#4721siRNA targeting complement factor B
#4722siRNA targeting BCL2L1
#4723siRNA targeting KRAS
#4724Methods of treatment and diagnosis using modulators of virus-induced cellular gene sequences
#4725Human microRNA targets in HIV genome and a method of identification thereof
#4726Method for inducing a specific rnai activity in cells and nucleic acids for carrying out said method
#4727FERRITIN AS A THERAPEUTIC TARGET IN ABNORMAL CELLS
#4728Multiple RNAi expression cassettes for simultaneous delivery of RNAi agents related to heterozygotic expression patterns
#4729Formulations comprising antisense nucleotides to connexins
#4730siRNA targeting survivin
#4731Formulations comprising antisense nucleotides to connexins
#4732Formulations comprising antisense nucleotides to connexins
#4733Oligonucleotide analogues incorporating 5-aza-cytosine therein
#4734Formulations comprising antisense nucleotides to connexins
#4735Aptamer medicinal chemistry
#4736Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAS and their target mRNAS
#4737Formulations comprising antisense nucleotides to connexins
#4738Pure miRNA Sample Preparation Method
#4739Micrornas and uses thereof
#4740Methods for producing microRNAs
#4741Oligonucleic acid-bearing composite and pharmaceutical composition containing the composite
#4742Bioinformatically detectable group of novel regulatory viral and viral associated oligonucleotides and uses thereof
#4743Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof
#4744Functional and hyperfunctional siRNA
#4745Oligonucleotide N3'-P5' thiophosphoramidates: their synthesis and use
#4746Formulations comprising antisense nucleotides to connexins
#4747ES cells having enhanced RNAi effect
#4748Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina)
#4749Functional and hyperfunctional siRNA
#4750Vaccinia virus-related nucleic acids and microRNA
#4751Methods and compositions for silencing genes without inducing toxicity
#4752Small interfering RNA with improved activity
#4753GLUCOSE TRANSPORT-RELATED GENES, POLYPEPTIDES, AND METHODS OF USE THEREOF
#4754Method and systems for identifying micro-RNA targets and synthesizing novel micro-RNAs and uses of the same
#4755RNAi expression constructs
#4756Compositions, formulations and kit with anti-sense oligonucleotide and anti-inflammatory steroid and/or obiquinone for treatment of respiratory and lung disesase
#4757Methods and compositions for RNA interference
#4758Nucleotides for prevention and treatment of bacterial and fungal pathologies
#4759Double stranded compositions comprising a 3′-endo modified strand for use in gene modulation
#4760Method of treatment of RNA sample
#4761RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4762RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4763RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4764RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4765Method and means for treatment of osteoarthritis
#4766RNA sequence-specific mediators of RNA interference
#4767RNA sequence-specific mediators of RNA interference
#4768RNA sequence-specific mediators of RNA interference
#4769RNA sequence-specific mediators of RNA interference
#4770Vectorization of dsRNA by cationic particles and topical use
#4771Viral and viral associated miRNAs and uses thereof
#4772Targets for tumor growth inhibition
#4773RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4774RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4775Dual functional oligonucleotides for use as anti-viral agents
#4776RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4777Methods for determining specificity of RNA silencing and for genetic analysis of the silenced gene or protein
#4778Short interfering nucleic acid hybrids and methods thereof
#4779RNA interference mediated ihibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4780Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides
#4781Oligonucleotides comprising a non-phosphate backbone linkage
#4782Compositions and methods for combined therapy of disease
#4783Transgenic plant-derived siRNAs for suppression of influenza virus propagation in mammalian cells
#4784Combinatorial selection of phosphorothioate aptamers for RNases
#4785RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4786RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4787Staple type oligonucleotide and drug comprising the same
#4788RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4789Methods of treatment and diagnosis of kaposi's sarcoma (ks) and ks related diseases
#4790Method of detecting target base sequence of rna interference, method of designing polynucleotide base sequence causing rna interference, method of constructing double-stranded polynucleotide, method of regulating gene expression, base sequence processing apparatus, program for running base sequence processing method on comp
#4791Antisense antiviral compound and method for treating ssRNA viral infection
#4792Small interference RNA gene therapy
#4793Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
#4794System and method for identification of MicroRNA precursor sequences and corresponding mature MicroRNA sequences from genomic sequences
#4795Methods and constructs for evaluation of rnai targets and effector molecules
#4796Methods of producing competitive aptamer fret reagents and assays
#4797Methods of producing intrachain fluorophore-quencher FRET-aptamers and assays
#4798Oligomeric compounds and compositions for use in modulation of pri-mirnas
#4799Retroviral vectors for delivery of interfering RNA
#4800Methods of identifying aberrant RNA or RNA targeted for cleavage by miRNA or siRNA