ClassID:

109047

C12N15/111 - page 6 - CPC Classification

Classification description:

Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof General methods applicable to biologically active non-coding nucleic acids

Recent Application in this class:
#1501
20210309701
2021-10-07

Inducible, tunable, and multiplex human gene regulation using CRISPR-Cpf1

#1502
20210308183
2021-10-07

CHIMERIC ANTIGEN RECEPTOR T CELLS DERIVED FROM IMMUNOENGINEERED PLURIPOTENT STEM CELLS

#1503
20210308171
2021-10-07

METHODS FOR COMBINATORIAL SCREENING AND USE OF THERAPEUTIC TARGETS THEREOF

#1504
20210301292
2021-09-30

Compositions of Asymmetric Interfering RNA and Uses Thereof

#1505
20210301288
2021-09-30

NOVEL CRISPR DNA TARGETING ENZYMES AND SYSTEMS

#1506
20210301287
2021-09-30

Treatment Of Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis, And Liver Fibrosis

#1507
20210301272
2021-09-30

Nuclease-mediated nucleic acid modification

#1508
20210301271
2021-09-30

CRISPR-Cas effector polypeptides and methods of use thereof

#1509
20210301269
2021-09-30

RECOMBINANT CRISPR-CAS9 NUCLEASES WITH ALTERED PAM SPECIFICITY

#1510
20210299280
2021-09-30

Compositions and methods for transient gene therapy with enhanced stability

#1511
20210292775
2021-09-23

System and Methods for Engineering Bacteria Fit for Eukaryotic mRNA Production, Export, and Translation in a Eukaryotic Host

#1512
20210292757
2021-09-23

Extended dicer substrate agents and methods for the specific inhibition of gene expression

#1513
20210292754
2021-09-23

NATURAL GUIDE ARCHITECTURES AND METHODS OF MAKING AND USING THE SAME

#1514
20210292303
2021-09-23

AMINE CATIONIC LIPIDS AND USES THEREOF

#1515
20210290704
2021-09-23

TARGETED ELIMINATION OF BACTERIAL GENES

#1516
20210284979
2021-09-16

METHODS AND COMPOSITIONS FOR GENETICALLY MANIPULATING GENES AND CELLS

#1517
20210284680
2021-09-16

ANTISENSE NUCLEIC ACIDS

#1518
20210277393
2021-09-09

CIRCULARIZED ENGINEERED RNA AND METHODS

#1519
20210277392
2021-09-09

CHEMICALLY-MODIFIED GUIDE RNAS TO IMPROVE CRISPR-CAS PROTEIN SPECIFICITY

#1520
20210277391
2021-09-09

Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors

#1521
20210274759
2021-09-09

A RODENT MODEL OF B4GALT1-MEDIATED FUNCTIONS

#1522
20210269799
2021-09-02

SYNTHETIC GUIDE MOLECULES, COMPOSITIONS AND METHODS RELATING THERETO

#1523
20210269798
2021-09-02

MODIFICATION OF SMALL RNAS FOR THERAPEUTIC USES

#1524
20210269785
2021-09-02

CRISPR-associated (Cas) protein

#1525
20210268015
2021-09-02

Sideroflexins as mitochondrial serine transporters

#1526
20210268013
2021-09-02

DELIVERY OF RNA TO DIFFERENT CELL TYPES

#1527
20210267895
2021-09-02

Lipid formulations for nucleic acid delivery

#1528
20210261982
2021-08-26

RAAV-MEDIATED NUCLEASE-ASSOCIATED VECTOR INTEGRATION (RAAV-NAVI)

#1529
20210261967
2021-08-26

Compositions and methods of inhibiting gene expression in a lung

#1530
20210261958
2021-08-26

Packaging oligonucleotides into virus-like particles

#1531
20210259980
2021-08-26

Compositions and methods for organ specific delivery of nucleic acids

#1532
20210259218
2021-08-26

Methods of genetic mediated engineering of RNAi models

#1533
20210254104
2021-08-19

CRISPR enabled multiplexed genome engineering

#1534
20210254071
2021-08-19

Oligonucleotide comprising an inosine for treating DMD

#1535
20210254065
2021-08-19

iRNA AGENTS WITH BIOCLEAVABLE TETHERS

#1536
20210254064
2021-08-19

Structurally designed shRNAs

#1537
20210254002
2021-08-19

Genetically-modified immune cells comprising a microRNA-adapted shRNA (shRNAmiR)

#1538
20210252114
2021-08-19

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

#1539
20210246450
2021-08-12

RAAV-based compositions and methods for treating amyotrophic lateral sclerosis

#1540
20210246439
2021-08-12

ENGINEERED BI-STABLE TOGGLE SWITCH AND USES THEREOF

#1541
20210238614
2021-08-05

METHODS AND COMPOSITIONS FOR HOMOLOGY DIRECTED REPAIR OF DOUBLE STRAND BREAKS IN PLANT CELL GENOMES

#1542
20210238601
2021-08-05

Oligonucleotide Conjugates

#1543
20210238591
2021-08-05

Selective antisense compounds and uses thereof

#1544
20210238587
2021-08-05

MRNA display antibody library and methods

#1545
20210238567
2021-08-05

CRISPR-Cas effector polypeptides and methods of use thereof

#1546
20210238544
2021-08-05

Enhanced placental stem cells and uses thereof

#1547
20210238248
2021-08-05

Engineering Extracellular Vesicles for Affinity Purification

#1548
20210230639
2021-07-29

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1549
20210230630
2021-07-29

INDUCIBLE MODIFICATION OF A CELL GENOME

#1550
20210230606
2021-07-29

METHODS AND COMPOSITIONS FOR ENHANCING FUNCTIONAL MYELIN PRODUCTION

#1551
20210230597
2021-07-29

Micro-RNAS and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions

#1552
20210230595
2021-07-29

BIODEGRADABLE AND CLINICALLY-COMPATIBLE NANOPARTICLES AS DRUG DELIVERY CARRIERS

#1553
20210230592
2021-07-29

Targeted Self-Assembly of Functionalized Carbon Nanotubes on Tumors

#1554
20210228693
2021-07-29

PRECISE DELETION OF CHROMOSOMAL SEQUENCES IN VIVO AND TREATMENT OF NUCLEOTIDE REPEAT EXPANSION DISORDERS USING ENGINEERED NUCLEASES

#1555
20210222205
2021-07-22

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1556
20210222196
2021-07-22

MODIFIED AAV CONSTRUCTS AND USES THEREOF

#1557
20210222169
2021-07-22

ANTISENSE NUCLEIC ACIDS

#1558
20210222165
2021-07-22

Chemically Ligated RNAs for CRISPR/Cas9-lgRNA Complexes as Antiviral Therapeutic Agents

#1559
20210222164
2021-07-22

CRISPR-CAS SYSTEMS HAVING DESTABILIZATION DOMAIN

#1560
20210220287
2021-07-22

PEPTIDE/PARTICLE DELIVERY SYSTEMS

#1561
20210220274
2021-07-22

NOVEL LIPID FORMULATIONS FOR NUCLEIC ACID DELIVERY

#1562
20210214749
2021-07-15

DIRECTED EVOLUTION

#1563
20210213138
2021-07-15

Nucleic Acid Carriers And Therapeutic Methods of Use

#1564
20210207187
2021-07-08

POLYVINYL ALCOHOL-DEGRADING ENZYME AND PROCESS FOR PRODUCING THE SAME

#1565
20210207142
2021-07-08

STAT3 INHIBITORS AND USES THEREOF

#1566
20210207141
2021-07-08

Methods and compositions for inhibiting detoxification response

#1567
20210207137
2021-07-08

RNA-INTERFERENCE-INDUCING NUCLEIC ACID MOLECULE ABLE TO PENETRATE INTO CELLS, AND USE THEREFOR

#1568
20210207130
2021-07-08

METHODS AND COMPOSITIONS FOR THE MAKING AND USING OF GUIDE NUCLEIC ACIDS

#1569
20210205476
2021-07-08

Isolation of novel AAV's and uses thereof

#1570
20210198739
2021-07-01

METHODS FOR DETERMINING THE PRESENCE OR RISK OF DEVELOPING FACIOSCAPULOHUMERAL DYSTROPHY (FSHD)

#1571
20210198661
2021-07-01

Methods for extending polynucleotides

#1572
20210198306
2021-07-01

Antisense nucleic acids

#1573
20210180090
2021-06-17

Nucleic acid-guided nucleases

#1574
20210180064
2021-06-17

Exon skipping compositions for treating muscular dystrophy

#1575
20210180060
2021-06-17

MULTIPLE EXON SKIPPING COMPOSITIONS FOR DMD

#1576
20210179659
2021-06-17

ANTISENSE NUCLEIC ACIDS

#1577
20210171951
2021-06-10

Oligonucleotides comprising modified nucleosides

#1578
20210163942
2021-06-03

Agents useful in treating facioscapulohumeral muscular dystrophy

#1579
20210163941
2021-06-03

AGENTS USEFUL IN TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY

#1580
20210162066
2021-06-03

RNA/DNA HYBRID NANOPARTICLES MODIFIED WITH SINGLE STRANDED RNA TOEHOLDS AND USES THEREOF

#1581
20210162053
2021-06-03

NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS

#1582
20210162005
2021-06-03

Fusion protein between short form rod-derived cone viability factor and a hydrophilic peptide

#1583
20210161125
2021-06-03

Composition for inhibiting ice recrystallization

#1584
20210147853
2021-05-20

Use of trinucleotide repeat RNAs to treat cancer

#1585
20210147849
2021-05-20

REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS

#1586
20210147845
2021-05-20

ANTISENSE POLYNUCLEOTIDES TO INDUCE EXON SKIPPING AND METHOD OF TREATING DYSTROPHIES

#1587
20210147838
2021-05-20

Selective Antisense Compounds and Uses Thereof

#1588
20210147837
2021-05-20

Oligomeric Compounds Comprising Bicyclic Nucleotides and Uses Thereof

#1589
20210147835
2021-05-20

Targeted delivery system

#1590
20210140956
2021-05-13

REFERENCE APTAMER SENSING ELEMENTS FOR EAB BIOSENSORS

#1591
20210139913
2021-05-13

Antisense oligonucleotides useful in treatment of Pompe disease

#1592
20210139891
2021-05-13

MODIFIED GUIDE RNAS, CRISPR-RIBONUCLEOTPROTEIN COMPLEXES AND METHODS OF USE

#1593
20210139890
2021-05-13

NOVEL CRISPR RNA TARGETING ENZYMES AND SYSTEMS AND USES THEREOF

#1594
20210130838
2021-05-06

SYSTEMS AND METHODS FOR PLANT GENOME EDITING USING CAS 12a ORTHOLOGS

#1595
20210130823
2021-05-06

COMPOSITIONS AND METHODS

#1596
20210130821
2021-05-06

Chiral control

#1597
20210130804
2021-05-06

Method to inactivate a mutant allele of an gene

#1598
20210123046
2021-04-29

Optimized small guide RNAs and methods of use

#1599
20210122793
2021-04-29

De novo designed non-local beta sheet proteins

#1600
20210115470
2021-04-22

Method for creating new germplasm of male sterile crop by gene editing and application thereof

#1601
20210115443
2021-04-22

Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof

#1602
20210115083
2021-04-22

RNA nanoparticles for brain tumor treatment

#1603
20210108231
2021-04-15

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1604
20210108220
2021-04-15

Simultaneous gene silencing and suppressing gene silencing in ihe same cell

#1605
20210108208
2021-04-15

TARGETED AUGMENTATION OF NUCLEAR GENE OUTPUT

#1606
20210108205
2021-04-15

MicroRNA Compounds and Methods for Modulating MIR-122

#1607
20210107948
2021-04-15

Hybrid recombinant adeno-associated virus serotype between AAV9 and AAVrh74 with reduced liver tropism

#1608
20210106695
2021-04-15

Methods of delivering anionic agents in vivo using non-viral nanoparticle-based delivery systems

#1609
20210102208
2021-04-08

COMPOSITIONS AND METHODS FOR NUCLEIC ACID TRANSFER

#1610
20210101875
2021-04-08

Aminoalcohol lipidoids and uses thereof

#1611
20210093568
2021-04-01

LOADING OF EXTRACELLULAR VESICLES THROUGH IMPARTING OF MECHANICAL SHEAR

#1612
20210092961
2021-04-01

Insecticidal proteins from plants and methods for their use

#1613
20210087588
2021-03-25

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1614
20210087573
2021-03-25

METHODS AND COMPOSITIONS FOR HOMOLOGY-DIRECTED REPAIR OF CAS ENDONUCLEASE MEDIATED DOUBLE STRAND BREAKS

#1615
20210087566
2021-03-25

Compositions and methods for modulating apolipoprotein (a) expression

#1616
20210087553
2021-03-25

Modified promoter

#1617
20210087219
2021-03-25

OLIGONUCLEOTIDES COMPRISING ACYCLIC AND ABASIC NUCLEOSIDES AND ANALOGS

#1618
20210085803
2021-03-25

METHOD FOR OPENING TIGHT JUNCTIONS

#1619
20210085793
2021-03-25

Branched oligonucleotides

#1620
20210079428
2021-03-18

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1621
20210079396
2021-03-18

Anti-connexin compounds targeted to connexins and methods of use thereof

#1622
20210079391
2021-03-18

Antisense oligonucleotide compositions

#1623
20210079389
2021-03-18

GUIDE RNA WITH CHEMICAL MODIFICATIONS

#1624
20210079367
2021-03-18

CRISPR-associated (CAS) protein

#1625
20210077520
2021-03-18

Vesicles comprising a PTEN inhibitor and uses of same

#1626
20210069303
2021-03-11

Methods and compositions for RNA-guided treatment of HIV infection

#1627
20210069245
2021-03-11

MIRNA MODULATION OF T CELL SIGNALING AND USES THEREOF

#1628
20210062226
2021-03-04

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1629
20210062225
2021-03-04

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1630
20210062224
2021-03-04

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1631
20210062223
2021-03-04

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1632
20210062198
2021-03-04

Interfering RNA molecules

#1633
20210062189
2021-03-04

Extended dicer substrate agents and methods for the specific inhibition of gene expression

#1634
20210054373
2021-02-25

COMPLEX OF POLYSACCHARIDE AND DOUBLE-STRANDED RNA AND METHOD OF INHIBITING EXPRESSION OF A TARGET GENE IN A CELL

#1635
20210052622
2021-02-25

DEFIBROTIDE FOR USE IN PROPHYLAXIS AND/OR TREATMENT OF GRAFT VERSUS HOST DISEASE (GVHD)

#1636
20210052497
2021-02-25

Liposomal particles, methods of making same and uses thereof

#1637
20210047648
2021-02-18

COMPOSITION FOR CLEAVING A TARGET DNA COMPRISING A GUIDE RNA SPECIFIC FOR THE TARGET DNA AND CAS PROTEIN-ENCODING NUCLEIC ACID OR CAS PROTEIN, AND USE THEREOF

#1638
20210047647
2021-02-18

COMPOSITION FOR CLEAVING A TARGET DNA COMPRISING A GUIDE RNA SPECIFIC FOR THE TARGET DNA AND CAS PROTEIN-ENCODING NUCLEIC ACID OR CAS PROTEIN, AND USE THEREOF

#1639
20210040483
2021-02-11

Modified oligonucleotides and methods of use

#1640
20210040482
2021-02-11

Antisense molecules and methods for treating pathologies

#1641
20210040460
2021-02-11

Genetic correction of mutated genes

#1642
20210040175
2021-02-11

Artificial Target Cells for in-vitro CAR Cytotoxicity and ADCC validation

#1643
20210038631
2021-02-11

Modulators of IRF4 expression

#1644
20210038519
2021-02-11

Lipid-derived neutral nanoparticles

#1645
20210032625
2021-02-04

Transgenic microalgae and use thereof as a feed for delivery of interfering RNA molecules

#1646
20210024935
2021-01-28

Read through of truncated proteins in premature termination codon diseases using an optimized genetic codon expansion system

#1647
20210024926
2021-01-28

Fully stabilized asymmetric siRNA

#1648
20210024923
2021-01-28

COMPOSITIONS AND METHODS FOR MODULATING TTR EXPRESSION

#1649
20210023227
2021-01-28

Methods And Compositions For Templated Assembly Of Nucleic Acid Specific Heterocompounds

#1650
20210023039
2021-01-28

PKC PATHWAY IN PARKINSON'S DISEASE

#1651
20210017519
2021-01-21

Modified double-stranded RNA agents

#1652
20210017517
2021-01-21

Synthetic nucleic acids having non-natural structures

#1653
20210010003
2021-01-14

Combination comprising immunostimulatory oligonucleotides

#1654
20210009994
2021-01-14

Direct oligonucleotide synthesis on cells and biomolecules

#1655
20210009483
2021-01-14

METHODS AND COMPOSITIONS FOR IMPROVING PLANT TRAITS

#1656
20210008181
2021-01-14

Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors

#1657
20210002709
2021-01-07

BACTERIAL IDENTIFICATION METHOD USING RNA OF SAMPLE BACTERIA, AND KIT THEREFOR

#1658
20210002643
2021-01-07

Methods and compositions for modulating apolipoprotein (a) expression

#1659
20210002217
2021-01-07

Method of synthesis of an ionizable cationic lipid

#1660
20200407717
2020-12-31

METHODS OF MODULATING ANTISENSE ACTIVITY

#1661
20200404891
2020-12-31

Method for generating a genetically modified pig with inactivated porcine endogenous retrovirus (PERV) elements

#1662
20200400684
2020-12-24

Nourin gene-based RNA molecular network: novel early diagnostic and prognostic biomarkers for coronary artery disease, unstable angina, STEMI/NSTEMI and heart failure

#1663
20200399621
2020-12-24

Engineered CRISPR-Cas9 nucleases with altered PAM specificity

#1664
20200399620
2020-12-24

Engineered CRISPR-Cas9 nucleases with altered PAM specificity

#1665
20200397712
2020-12-24

NOVEL RNAi MOLECULE DELIVERY PLATFORM BASED ON SINGLE-siRNA AND shRNA NANOCAPSULES

#1666
20200392576
2020-12-17

Method for diagnosis of Alzheimer's disease using microRNA

#1667
20200392539
2020-12-17

CRISPR enabled multiplexed genome engineering

#1668
20200392538
2020-12-17

ITERATIVE GENOME ASSEMBLY

#1669
20200392499
2020-12-17

Short interfering nucleic acid (siNA) compositions

#1670
20200392493
2020-12-17

Oligomeric compounds comprising bicyclic nucleotides and uses thereof

#1671
20200392488
2020-12-17

Method for screening splicing variants or events

#1672
20200385721
2020-12-10

DELIVERING CRISPR THERAPEUTICS WITH LIPID NANOPARTICLES

#1673
20200377919
2020-12-03

Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase

#1674
20200377890
2020-12-03

CTLA-4 aptamer conjugates

#1675
20200377879
2020-12-03

Modulating dsRNA editing, sensing, and metabolism to increase tumor immunity and improve the efficacy of cancer immunotherapy and/or modulators of intratumoral interferon

#1676
20200370043
2020-11-26

Methods for modifying RNA splicing

#1677
20200370014
2020-11-26

Genetically-modified immune cells comprising a microRNA-adapted shRNA (shRNAmiR)

#1678
20200369613
2020-11-26

Integrin ligands and uses thereof

#1679
20200362370
2020-11-19

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1680
20200362369
2020-11-19

Protected guide RNAS (pgRNAS)

#1681
20200362343
2020-11-19

METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT

#1682
20200354750
2020-11-12

Method of target cleaving using CRISPR hybrid DNA/RNA polynucleotides

#1683
20200354749
2020-11-12

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1684
20200354748
2020-11-12

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1685
20200354747
2020-11-12

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1686
20200354746
2020-11-12

Methods for genomic integration

#1687
20200354702
2020-11-12

Polynucleotides, compositions, and methods for genome editing

#1688
20200352143
2020-11-12

Method to Implement a CRISPR Gene Drive in Mammals

#1689
20200348286
2020-11-05

Oligonucleotides for inducing paternal UBE3A expression

#1690
20200347388
2020-11-05

Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves

#1691
20200345640
2020-11-05

Liposomes for modulating Wiskott-Aldrich syndrome protein

#1692
20200340011
2020-10-29

RECOMBINANT INSECT VECTORS AND METHODS OF USE

#1693
20200339998
2020-10-29

COMPLEMENT COMPONENT iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1694
20200339990
2020-10-29

RNAi CONJUGATES, PARTICLES AND FORMULATIONS THEREOF

#1695
20200339989
2020-10-29

NUCLEIC ACID NANOSTRUCTURES WITH CORE MOTIFS

#1696
20200339988
2020-10-29

RAAV-based compositions and methods

#1697
20200339984
2020-10-29

Multivalent oligonucleotide assemblies

#1698
20200339983
2020-10-29

Bioactive conjugates for oligonucleotide delivery

#1699
20200339982
2020-10-29

OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE

#1700
20200339980
2020-10-29

High Specificity Genome Editing Using Chemically Modified Guide RNAs

#1701
20200332336
2020-10-22

Compositions and methods for making selenocysteine containing polypeptides

#1702
20200332298
2020-10-22

ANTISENSE OLIGONUCLEOTIDE DIRECTED REMOVAL OF PROTEOLYTIC CLEAVAGE SITES FROM PROTEINS

#1703
20200332287
2020-10-22

DIFFERENTIAL KNOCKOUT OF AN ALLELE OF A HETEROZYGOUS FIBRINOGEN ALPHA CHAIN (FGA) GENE

#1704
20200325495
2020-10-15

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

#1705
20200318109
2020-10-08

LNA-G process

#1706
20200316210
2020-10-08

Cell-penetrating peptides for antisense delivery

#1707
20200308607
2020-10-01

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

#1708
20200308606
2020-10-01

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

#1709
20200308605
2020-10-01

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

#1710
20200308604
2020-10-01

CRISPR-related methods and compositions with governing gRNAS

#1711
20200308587
2020-10-01

Composition for delivery of genetic material

#1712
20200308578
2020-10-01

RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality

#1713
20200308552
2020-10-01

Expression cassette

#1714
20200299734
2020-09-24

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1715
20200299733
2020-09-24

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1716
20200299721
2020-09-24

Expression cassette for production of high-expression and high-functionality target protein and use thereof

#1717
20200299717
2020-09-24

Methods for genetic modification of plants

#1718
20200299693
2020-09-24

RNA INTERFERENCE MEDIATING SMALL RNA MOLECULES

#1719
20200299687
2020-09-24

Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves

#1720
20200299657
2020-09-24

Method for reducing an immune response by administering an immune evading adeno-associated AAV8 or AAVDJ viral vector

#1721
20200297966
2020-09-24

Therapy specific, pre-programmed auto injection device

#1722
20200291403
2020-09-17

ANTISENSE POLYNUCLEOTIDES TO INDUCE EXON SKIPPING AND METHOD OF TREATING DYSTROPHIES

#1723
20200291399
2020-09-17

Oligonucleotide comprising an inosine for treating DMD

#1724
20200291396
2020-09-17

METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF RNA SILENCING

#1725
20200289568
2020-09-17

DETERMINISTIC MECHANOPORATION FOR CELL ENGINEERING

#1726
20200289540
2020-09-17

Preeclampsia

#1727
20200289417
2020-09-17

Delivery method of target material into extracellular vesicles using extracorporeal shockwave

#1728
20200283776
2020-09-10

Splice Switching Oligomers for TNF Superfamily Receptors and Their Use in Treatment of Disease

#1729
20200283771
2020-09-10

ALBUMIN PRODUCTION AND CELL PROLIFERATION

#1730
20200283766
2020-09-10

Compositions and Methods for Inhibiting Expression of Transthyretin

#1731
20200283762
2020-09-10

Reducing nonsense-mediated MRNA decay

#1732
20200282069
2020-09-10

BIOTIN COMPLEXES FOR TREATMENT AND DIAGNOSIS OF ALZHEIMER'S DISEASE

#1733
20200282060
2020-09-10

NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF

#1734
20200281975
2020-09-10

Methods and compositions for gene editing in hematopoietic stem cells

#1735
20200277631
2020-09-03

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

#1736
20200277601
2020-09-03

SYNTHETIC HAMMERHEAD RIBOZYMES WITH LIGAND-RESPONSIVE TERTIARY INTERACTIONS

#1737
20200276222
2020-09-03

2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS

#1738
20200276221
2020-09-03

ANTISENSE COMPOUNDS

#1739
20200270607
2020-08-27

Methods and compositions for selecting siRNA of improved functionality

#1740
20200270602
2020-08-27

RNA SEQUENCE-SPECIFIC MEDIATORS OF RNA INTERFERENCE

#1741
20200268907
2020-08-27

Compositions and methods for the expression of CRISPR guide RNAs using the H1 promoter

#1742
20200268905
2020-08-27

RNA-modulating agents

#1743
20200263186
2020-08-20

ALTERED GUIDE RNAS FOR MODULATING CAS9 ACTIVITY AND METHODS OF USE

#1744
20200263183
2020-08-20

Complement component iRNA compositions and methods of use thereof

#1745
20200255866
2020-08-13

Gene knockout method

#1746
20200255833
2020-08-13

Therapeutic compositions

#1747
20200248173
2020-08-06

Enhanced selection of efficient targeted genome manipulating agents

#1748
20200239892
2020-07-30

MULTI-CONJUGATE OF SIRNA AND PREPARING METHOD THEREOF

#1749
20200239879
2020-07-30

Compositions and methods for regulating proteins and nucleic acids activities

#1750
20200239863
2020-07-30

Tracking and manipulating cellular RNA via nuclear delivery of CRISPR/CAS9

#1751
20200239600
2020-07-30

Dynamic control of colocalization of proteins

#1752
20200239535
2020-07-30

Cancer treatment

#1753
20200237922
2020-07-30

BICYCLIC PEPTIDE OLIGONUCLEOTIDE CONJUGATES

#1754
20200231987
2020-07-23

NUCLEIC ACID-GUIDED NUCLEASES

#1755
20200231969
2020-07-23

Reducing intron retention

#1756
20200231966
2020-07-23

Agents useful in treating facioscapulohumeral muscular dystrophy

#1757
20200231965
2020-07-23

Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors

#1758
20200225215
2020-07-16

SCREENING METHOD FOR SELECTED AMINO-LIPID-CONTAINING COMPOSITIONS

#1759
20200224220
2020-07-16

ENCAPSULATED POLYNUCLEOTIDES AND METHODS OF USE

#1760
20200224203
2020-07-16

ANTISENSE OLIGONUCLEOTIDE DIRECTED REMOVAL OF PROTEOLYTIC CLEAVAGE SITES, THE HCHWA-D MUTATION, AND TRINUCLEOTIDE REPEAT EXPANSIONS

#1761
20200224198
2020-07-16

COMPOSITIONS AND METHODS FOR MODULATING HBV EXPRESSION

#1762
20200222558
2020-07-16

Biodegradable lipids for delivery of nucleic acids

#1763
20200216842
2020-07-09

CONDITIONAL PROTEIN TRANSLATION SWITCHES, CONDITIONAL GENE EXPRESSION SYSTEMS AND USES THEREOF

#1764
20200216833
2020-07-09

Continuous evolution for stabilized proteins

#1765
20200215092
2020-07-09

Oligonucleotide analogues incorporating 5-aza-cytosine therein

#1766
20200214973
2020-07-09

Microbubble nucleic acid delivery platform

#1767
20200208155
2020-07-02

Engineered nucleic acid-targeting nucleic acids

#1768
20200207829
2020-07-02

CHIMERIC RECEPTORS

#1769
20200206361
2020-07-02

Methods of treating mitochondrial disorders

#1770
20200199674
2020-06-25

Methods and compositions for screening and treating developmental disorders

#1771
20200199650
2020-06-25

ANALYSIS SYSTEM FOR PERIPHERAL BLOOD-BASED NON-INVASIVE DETECTION OF LESION IMMUNE REPERTOIRE DIVERSITY AND USES OF SYSTEM

#1772
20200199597
2020-06-25

Modulatory polynucleotides

#1773
20200199595
2020-06-25

Allele-specific therapy for Huntington disease haplotypes

#1774
20200197536
2020-06-25

POROUS NANOPARTICLE-SUPPORTED LIPID BILAYER DELIVERY OF TRANSCRIPTIONAL GENE MODULATORS

#1775
20200190543
2020-06-18

DNA methylation editing kit and DNA methylation editing method

#1776
20200190542
2020-06-18

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#1777
20200190534
2020-06-18

Method of Off-Target Recording of Spacer Sequences within a Cell In Vivo

#1778
20200190518
2020-06-18

Peptide, complex of peptide and siRNA, and methods of use thereof

#1779
20200181649
2020-06-11

HYBRID FORMULATION OF RESPONSIVE POLYMERIC NANOCARRIERS FOR THERAPEUTIC AND DIAGNOSTIC DELIVERY

#1780
20200181623
2020-06-11

Systems, methods, and compositions for targeted nucleic acid editing

#1781
20200181613
2020-06-11

COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING

#1782
20200181611
2020-06-11

NUCLEIC ACIDS COMPRISING IMPREFECT HAIRPINS

#1783
20200181203
2020-06-11

Covalently fused viral coat proteins for the display of target molecules

#1784
20200172901
2020-06-04

Use of a combination of Dbait molecule and PARP inhibitors to treat cancer

#1785
20200165687
2020-05-28

PROBE AND METHOD FOR DETECTING TRANSCRIPT RESULTING FROM FUSION GENE AND/OR EXON SKIPPING

#1786
20200165607
2020-05-28

COMPOSITION AND METHOD OF USING MIR-302 PRECURSORS AS ANTI-CANCER DRUGS FOR TREATING HUMAN LUNG CANCER

#1787
20200157576
2020-05-21

Compositions and methods related to a type-II CRISPR-Cas system in

#1788
20200157575
2020-05-21

CRISPR enabled multiplexed genome engineering

#1789
20200157574
2020-05-21

CRISPR enabled multiplexed genome engineering

#1790
20200157565
2020-05-21

Compositions and methods for gene editing

#1791
20200157515
2020-05-21

Systems and methods for the treatment of hemoglobinopathies

#1792
20200157158
2020-05-21

Modulation of Wnt5a to Treat Glaucoma

#1793
20200155606
2020-05-21

CRISPR/RNA-guided nuclease systems and methods

#1794
20200149045
2020-05-14

Modulatory polynucleotides

#1795
20200149040
2020-05-14

Antisense nucleic acids

#1796
20200149023
2020-05-14

Engineered CRISPR-Cas9 nucleases with altered PAM specificity

#1797
20200147423
2020-05-14

Special fire protection system for runaway grass and forest fires and method for use

#1798
20200147142
2020-05-14

COMPOSITIONS AND METHODS FOR ENHANCING THE THERAPEUTIC POTENTIAL OF STEM CELLS

#1799
20200147121
2020-05-14

Micellic assemblies

#1800
20200147119
2020-05-14

Oligonucleotide analogues targeting human LMNA