109047 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof General methods applicable to biologically active non-coding nucleic acids
Reconfigurable DNA nano-tweezer
#1802METHODS FOR THE TREATMENT OF DISEASE WITH GENE EDITING SYSTEMS
#1803Long non-coding RNA in cancer
#1804Enhancement of CRISPR gene editing or target destruction by co-expression of heterologous DNA repair protein
#1805Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids
#1806Antisense nucleic acids
#1807METHODS FOR ENHANCED PRODUCTION AND ISOLATION OF CELL-DERIVED VESICLES AND TREATMENT OF INFLAMMATION AND NEUROLOGICAL DAMAGE
#1808P-ethoxy nucleic acids for liposomal formulation
#1809NOVEL LIPID FORMULATIONS FOR NUCLEIC ACID DELIVERY
#1810HIV pre-immunization and immunotherapy
#1811In vivo delivery of oligonucleotides
#1812Antisense nucleic acids
#1813Transkingdom platform for therapeutic nucleic acid delivery
#1814Antisense nucleic acids
#1815COMPOSITIONS AND METHODS FOR NUCLEIC ACID AND/OR PROTEIN PAYLOAD DELIVERY
#1816Peptide nucleic acid conjugates
#1817FORMULATION COMPRISING EXTRACELLULAR VESICLES, METHOD FOR PRODUCING THE SAME, AND USES THEREOF
#1818TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A CHST15 INHIBITOR
#1819COMPOUNDS TARGETING LONG NON CODING RNA FOR THE TREATMENT OF CANCER
#1820CRISPR enzyme mutations reducing off-target effects
#1821NANOSCALE CARRIERS FOR THE DELIVERY OR CO-DELIVERY OF CHEMOTHERAPEUTICS, NUCLEIC ACIDS AND PHOTOSENSITIZERS
#1822Method for selective translation of desired proteins in the presence of a specified nucleic acid ligand
#1823Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#1824Compositions and methods for loading extracellular vesicles with chemical and biological agents/molecules
#1825Cationic lipid
#1826CRISPR-associated (Cas) protein
#1827METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#1828Compositions of asymmetric interfering RNA and uses thereof
#1829DELIVERY OF THERAPEUTIC AGENT
#1830Anti-connexin compounds targeted to connexins and methods of use thereof
#1831Therapeutic alteration of transplantable tissues through in situ or ex vivo exposure to RNA interference molecules
#1832Compositions of asymmetric interfering RNA and uses thereof
#1833DNA WRITERS, MOLECULAR RECORDERS AND USES THEREOF
#1834Methods for RNA promoter identification
#1835Oligonucleotides for inducing paternal UBE3A expression
#1836CRISPR hybrid DNA/RNA polynucleotides and methods of use
#1837Targeted nanocarriers for the administration of immunosuppressive agents
#1838Regulation of gene expression by aptamer-modulated RNase p cleavage
#1839Oligonucleotide compositions and methods thereof
#1840Dually derivatized chitosan nanoparticles and methods of making and using the same for gene transfer in vivo
#1841Compositions comprising bacterially derived minicells and methods of using the same
#1842Methods to detect motor neuron disease comprising micro-RNAs
#1843Novel Structurally Designed shRNAs
#1844Antisense Oligonucleotides for Treatment of Spinal Muscular Atrophy
#1845Electroporation, developmentally-activated cells, pluripotent-like cells, cell reprogramming and regenerative medicine
#1846Peptide-polynucleotide complex for polynucleotide transfection
#1847Methods of preserving the biological activity of ribonucleic acids
#1848ANTISENSE POLYNUCLEOTIDES TO INDUCE EXON SKIPPING AND METHOD OF TREATING DYSTROPHIES
#1849EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
#1850Gene silencing
#1851Morpholino oligonucleotide manufacturing method
#1852System for the biocontrol of pathogens in aquaculture and other animal systems
#1853Methods and compositions for controlling efficacy of RNA silencing
#1854Compositions and methods for modulation of IKBKAP splicing
#1855RAAV-based compositions and methods for treating amyotrophic lateral sclerosis
#1856Regulation of gene expression via aptamer-mediated control of self-cleaving ribozymes
#1857Methods and polynucleotides for amplifying a target polynucleotide
#1858Lin28-mediated control of let-7 biogenesis
#1859Compositions and methods for the delivery of nucleic acids
#1860LIGAND-MODIFIED DOUBLE-STRANDED NUCLEIC ACIDS
#1861Method for blocking miRNA
#1862Exosomes and micro-ribonucleic acids for tissue regeneration
#1863METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF SINGLE AND DOUBLE BLUNT-ENDED siRNA
#1864RNA interference for the treatment of gain-of-function disorders
#1865Liposomal particles, methods of making same and uses thereof
#1866Mapping a Functional Cancer Genome Atlas of Tumor Suppressors Using AAV-CRISPR Mediated Direct In Vivo Screening
#1867COMPOSITIONS AND METHODS FOR STUDYING THE TAT GENE
#1868Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
#1869Methods for identifying treatment targets based on multiomics data
#1870CRISPR/CAS9-BASED TREATMENTS
#1871NUCLEASE FUSIONS FOR ENHANCING GENOME EDITING BY HOMOLOGY-DIRECTED TRANSGENE INTEGRATION
#1872Immunomodulatory polynucleotides and uses thereof
#1873Reduced size self-delivering RNAI compounds
#1874EFFICIENT PROTEIN EXPRESSION IN VIVO USING MODIFIED RNA (MOD-RNA)
#1875CRISPR enabled multiplexed genome engineering
#1876Nucleic acid-guided nucleases
#1877Cas9 proteins and guiding features for DNA targeting and genome editing
#1878Interfering RNA molecules
#18793′ end caps for RNAi agents for use in RNA interference
#1880MODIFIED GUIDE RNAS, METHODS AND USES
#1881Multiple oligonucleotide moieties on peptide carrier
#1882Use of aptamers in proteomics
#1883NOVEL CRISPR ENZYMES AND SYSTEMS
#1884NOVEL CRISPR ENZYMES AND SYSTEMS
#1885MODIFIED CRISPR RNA AND USES THEREOF
#1886Isolated mammalian somatic cells containing modified RNA encoding OCT4, SOX2, and KLF4
#1887Method of treating diseases associated with elevated KRAS expression using CRISPR-GNDM system
#1888CRISPR enabled multiplexed genome engineering
#1889siRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAI, and stabilized forms thereof
#1890Methods of modulating expression of target nucleic acid sequences in a cell
#1891Permanent gene correction by means of nucleotide-modified messenger RNA
#1892Compositions and related methods for modulating endosymbionts
#1893Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
#1894COMPOSITIONS AND METHODS FOR DELIVERING MICRORNA
#1895Conjugated antisense compounds and their use
#1896Gene vector
#1897Recombinant polypepties for membrane fusion and uses thereof
#1898Compositions and methods for the expression of CRISPR guide RNAS using the H1 promoter
#1899Synthetic nanostructures including nucleic acids and/or other entities
#1900Composition and method for oligonucleotide delivery
#1901Adjustable method for sustainable human cognitive enhancement
#1902Oligomeric compounds comprising α-β-constrained nucleic acid
#1903Type VI CRISPR orthologs and systems
#1904Oligonucleotide complexes for use in RNA editing
#1905Genome editing reagents and their use
#1906Simplified method for size-purification of small oligonucleotides via gel electrophoresis
#1907COMPOSITIONS FOR THE INACTIVATION OF VIRUS REPLICATION AND METHODS OF MAKING AND USING THE SAME
#1908Methods and Compositions for Selecting siRNA of Improved Functionality
#1909NOVEL CRISPR ENZYMES AND SYSTEMS
#1910Modified iRNA agents
#1911Cas9 variants and methods of use thereof
#1912HYBRID NUCLEIC ACID MOLECULES AND THEIR USE
#1913Nucleic acid nanoswitch construction methods
#1914Targeted CRISPR Delivery Platforms
#1915SELECTIVE ANTISENSE COMPOUNDS AND USES THEREOF
#1916Method of making peptide-tagged PEGylated chitosan nanoparticles
#1917Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#1918Methods and compositions for multiplex RNA guided genome editing and other RNA technologies
#1919EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
#1920Single-stranded RNA-editing oligonucleotides
#1921Methods for ameliorating infusion reactions
#1922Methods and Compositions for Selecting siRNA of Improved Functionality
#1923Oligonucleotide compositions with enhanced efficiency
#1924Combination comprising immunostimulatory oligonucleotides
#1925Compositions and methods for controlling insect pests
#1926DELIVERY OF dsRNA TO ARTHROPODS
#1927RAAV-based compositions and methods for treating amyotrophic lateral sclerosis
#1928ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS
#1929METHODS AND COMPOSITIONS FOR GENETICALLY MANIPULATING GENES AND CELLS
#1930Antisense nucleic acids
#1931Compositions for in vivo Expression of Therapeutic Sequences in the Microbiome
#1932NUCLEIC ACID CONSTRUCTS INCLUDING A TXNIP PROMOTER FOR THE TREATMENT OF DISEASE
#1933Oligonucleotides for inducing paternal UBE3A expression
#1934Process of delivering small RNAs to sperm
#1935Compositions and Methods for Inhibiting Expression of Transthyretin
#1936Compounds and methods for enhanced cellular uptake
#1937Methods for modification of target nucleic acids
#1938Processes and host cells for genome, pathway, and biomolecular engineering
#1939Modular platform for targeted therapeutics
#1940Soluble TNF Receptors and Their Use in Treatment of Disease
#1941Recombinant protein-based method for the delivery of silencer RNA to target the brain
#1942METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
#1943Compositions for transfecting resistant cell types
#1944Method for modifying genes
#1945SINGLE-CHAIN CIRCULAR RNA AND METHOD OF PRODUCING THE SAME
#1946Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#1947MULTIPLE EXON SKIPPING COMPOSITIONS FOR DMD
#1948Isolation of novel AAV's and uses thereof
#1949RAAV-based compositions and methods for treating amyotrophic lateral sclerosis
#1950Recombinant adeno-associated virus delivery of exon 2-targeted U7SNRNA polynucleotide constructs
#1951Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#1952Chimeric double-stranded nucleic acid
#1953Antisense molecules and methods for treating pathologies
#1954Nanoparticles comprising protein-polynucleotide complexes and for delivering protein based complexes
#1955Methods and compositions for the making and using of guide nucleic acids
#1956Promoter for cell-specific gene expression and uses thereof
#1957Nanoparticles for chemotherapy, targeted therapy, photodynamic therapy, immunotherapy, and any combination thereof
#1958Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#1959Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#1960Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#1961Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#1962CRISPR enabled multiplexed genome engineering
#1963Therapeutic compositions
#1964GLYCOCONJUGATES OF RNA INTERFERENCE AGENTS
#1965Generic System of Antisense Oligonucleotide
#1966Biosensor for detecting the presence of bacteria
#1967Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#1968Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#1969Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#1970Methods for creating bilayers for use with nanopore sensors
#1971METHODS AND COMPOSITIONS OF BIOLOGICALLY ACTIVE AGENTS
#1972Branched oligonucleotides
#1973COMPOSITIONS AND RELATED METHODS FOR MODULATING ENDOSYMBIONTS
#1974Antisense oligonucleotides useful in treatment of Pompe disease
#1975Modified double-stranded RNA agents
#1976Modified double-stranded RNA agents
#1977METHODS AND COMPOSITIONS FOR MANIPULATING TRANSLATION OF PROTEIN ISOFORMS FROM ALTERNATIVE INITIATION START SITES
#1978Compositions and methods for delivering messenger RNA
#1979Lipid formulations for delivery of therapeutic agents
#1980RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1981PNA probe
#1982CRISPR enzymes and systems
#1983Compositions and methods for nanoparticle lyophile forms
#1984Methods and compositions for genome editing in non-dividing cells
#1985TARGETED GENOME OPTIMIZATION IN PLANTS
#1986COMPOSITIONS AND METHODS OF INHIBITING GENE EXPRESSION IN A LUNG
#1987Antisense nucleic acids
#1988Neutral nanotransporters
#1989Polycation-Functionalized Nanoporous Silicon Carrier for Systemic Delivery of Gene Silencing Agents
#1990RAAV-based compositions and methods
#1991Antisense nucleic acids
#1992Antisense nucleic acids
#1993Methods for treating cells containing fusion genes
#1994Carboxylated 2′-amino-LNA nucleotides and oligonucleotides comprising the same
#1995COMPOSITIONS AND METHODS FOR PREPARING SHORT RNA MOLECULES AND OTHER NUCLEIC ACIDS
#1996Production of viruses in avian eggs
#1997HIV pre-immunization and immunotherapy
#1998CRISPR enabled multiplexed genome engineering
#1999ANTISENSE POLYNUCLEOTIDES TO INDUCE EXON SKIPPING AND METHOD OF TREATING DYSTROPHIES
#2000RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)
#2001Anti-connexin compounds targeted to connexins and methods of use thereof
#2002COMBINATION
#2003Lipid-derived neutral nanoparticles
#2004Multi-conjugate of SiRNA and preparing method thereof
#2005Conjugated oligonucleotides
#2006Aptamer methods and compositions
#2007Assembly system for a eukaryotic cell
#2008CRISPR-associated (CAS) protein
#2009Human induced pluripotent stem cells for high efficiency genetic engineering
#2010Nucleic acid molecules inducing RNA interference, and uses thereof
#2011Oligonucleotides comprising modified nucleosides
#2012METHOD OF REGULATING GENE EXPRESSION
#2013Exon skipping compositions for treating muscular dystrophy
#2014Frequency-based modulation of diverse species in a nucleic acid library
#2015Genomic sequences encoding for an attenuated mutant Zika virus
#2016Aminoalcohol lipidoids and uses thereof
#2017Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#2018METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#2019METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#2020METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#2021METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#2022Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#2023Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#2024Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#2025Methods and compositions or RNA-directed target DNA modification and for RNA-directed modulation of transcription
#2026CRISPR-related methods and compositions with governing gRNAs
#2027Nucleic acids and methods for the treatment of Pompe disease
#2028Modulatory polynucleotides
#2029Methods of Manipulating the Fate of Cells
#2030OLIGOMERIC COMPOUNDS COMPRISING BICYCLIC NUCLEOTIDES AND USES THEREOF
#2031Modified RNAi polynucleotides and uses thereof
#2032Lipids and compositions for the delivery of therapeutics
#2033Reduced size self-delivering RNAI compounds
#2034Methods for cleaving DNA and RNA molecules
#2035Targeted nucleic acid conjugate compositions
#2036Exosome-based therapeutics against neurodegenerative disorders
#2037CRISPR-CAS SYSTEMS FOR ALTERING EXPRESSION OF GENE PRODUCTS
#2038Composition for delivery of genetic material
#2039METHODS FOR INCREASING EFFICACY OF LIPID FORMULATED siRNA
#2040MRNA display antibody library and methods
#2041Therapeutic applications of CPF1-based genome editing
#2042Process for formulating an anionic agent
#2043Fusion protein between short form rod-derived cone viability factor and a hydrophilic peptide
#2044CRISPR/Cas9 complex for genomic editing
#2045POLYNUCLEOTIDE ENCODING FUSION OF ANCHORING MOTIF AND DEHALOGENASE, HOST CELL INCLUDING THE POLYNUCLEOTIDE, AND USE THEREOF
#2046MicroRNA Compounds and Methods for Modulating MIR-122
#2047Method for gene editing
#2048Methods and compositions for improving plant traits
#2049Therapy specific, pre-programmed auto injection device
#2050Therapy specific, pre-programmed auto injection device
#2051HPV particles and uses thereof
#2052Oligomer-conjugate complexes and their use
#2053LIPID NANOPARTICLE FORMULATIONS FOR CRISPR/CAS COMPONENTS
#2054Compositions and methods of improving specificity in genomic engineering using RNA-guided endonucleases
#2055STEM CELLS FOR MODELING TYPE 2 DIABETES
#2056RNA CONSTRUCTS
#2057MULTIPLE EXON SKIPPING COMPOSITIONS FOR DMD
#2058Nucleic acid and other compositions and methods for the modulation of cell membranes
#2059SMALL INTERFERENCE RNA COMPLEX WITH INCREASED INTRACELLULAR TRANSMISSION CAPACITY
#2060Adeno-associated virus vector delivery of microrna-29 to treat muscular dystrophy
#2061EFFICIENT PROTEIN EXPRESSION IN VIVO USING MODIFIED RNA (MOD-RNA)
#2062CONDITIONAL PROTEIN TRANSLATION SWITCHES, CONDITIONAL GENE EXPRESSION SYSTEMS AND USES THEREOF
#2063Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#2064Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#2065Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#2066Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#2067Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#2068RNA nanoparticles for brain tumor treatment
#2069NOVEL CYCLIC CATIONIC LIPIDS AND METHODS OF USE
#2070Oligonucleotides for treating expanded repeat diseases
#2071Nuclease resistant polynucleotides and uses thereof
#2072Nanocapsule delivery system for ribonucleoproteins
#2073Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#2074Methods and compositions for increased double stranded RNA production
#2075Crispr enzymes and systems
#2076Exosome packaging of nucleic acids
#2077Coexpression of CAS9 and TREX2 for targeted mutagenesis
#2078Compositions and methods for the delivery of nucleic acids
#2079THERAPEUTIC TARGETS FOR LIN-28-EXPRESSING CANCERS
#2080Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells
#2081Methods for creating bilayers for use with nanopore sensors
#2082In-vitro induction of adult stem cell expansion and derivation
#2083Defined multi-conjugate oligonucleotides
#2084In vivo gene silencing by chemically modified and stable siRNA
#2085Bacteria-Mediated Gene Modulation Via microRNA Machinery
#2086Conditional CRISPR sgRNA expression
#2087Amine cationic lipids and uses thereof
#2088TKI permeability enhancers
#2089BIOSYNTHETIC MODULES
#2090Polynucleotides containing a morpholino linker
#2091Conjugates enhancing total cellular accumulation
#2092Nanoparticle to target cancer
#2093LIPID ENCAPSULATING INTERFERING RNA
#2094COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND TREATMENT OF CANCER USING SLNCR ISOFORMS
#2095Nano/micromotors for active and dynamic intracellular payload delivery
#2096Biodegradable vectors for efficient RNA delivery
#2097Antisense oligomers and uses thereof
#2098METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#2099Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA
#2100Read Through Of Truncated Proteins In Premature Termination Codon Diseases Using An Optimized Genetic Codon Expansion System