109048 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Compounds and methods for trans-membrane delivery of molecules
#8102Lipocationic polymers and uses thereof
#8103Genomic instability markers in Fanconi anemia
#8104Use of CPNE7 for differentiating non-dental mesenchymal stem cells into odontoblasts, regenerating dental pulp and treating dentin hypersensitivity
#8105METHOD OF GENERATING STERILE TERMINAL SIRES IN LIVESTOCK AND ANIMALS PRODUCED THEREBY
#8106AAV vectors for retinal and CNS gene therapy
#8107MicroRNA induction of cardiac regeneration
#8108Diagnosis and treatment of Friedreich's ataxia
#8109Compounds and methods for enhanced cellular uptake
#8110INHIBITING GENE EXPRESSION WITH dsRNA
#8111METHOD OF THERAPY AND DIAGNOSIS OF ENDOTHELIAL DYSFUNCTION
#8112Compositions and methods for inhibiting gene expression of LPA
#8113Spinal muscular atrophy (SMA) treatment via targeting of SMN2 splice site inhibitory sequences
#8114siRNA Therapy for Transthyretin (TTR) Related Ocular Amyloidosis
#8115ADMINISTERING ANTISENSE OLIGONUCLEOTIDES COMPLEMENTARY TO HUMAN APOLIPOPROTEIN B
#8116Diblock copolymers and polynucleotide complexes thereof for delivery into cells
#8117AGENTS INHIBITING GRANULIN FOR TREATMENT OF CANCER
#8118Neurotensin-induced tumor formation is regulated by micro RNA 133A-aftiphilin-dependent receptor recycling
#8119Compositions and methods for controlling arthropod parasite and pest infestations
#8120Methods for enhancing or decreasing the levels of MIR124 and MIR29 in subjects with muscular dystrophy
#8121TREATMENT AND PREVENTION OF ADRENOCORTICAL CARCINOMA
#8122COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING
#8123MicroRNA composition for the treatment of neuroblastoma
#8124Antibody-Based Depletion of Antigen-Presenting Cells and Dendritic Cells
#8125Targeted extracellular vesicles comprising membrane proteins with engineered glycosylation sites
#8126Method for Selecting Patient Subpopulation for Custirsen Treatment
#8127Methods for Inhibiting Epithelial to Mesenchymal Transition by Inhibition of FOXS1
#8128Methods for modulating KLHL1 levels, methods for modulating current activity in T-type calcium channels, molecules therefor, and methods for identifying molecules therefor
#8129Retinoid-lipid drug carrier
#8130COMPOUNDS, COMPOSITION, METHODS, TARGETS FOR CANCER THERAPY
#8131Cell penetrating peptides for intracellular delivery of molecules
#8132Oligonucleic acid variant libraries and synthesis thereof
#8133Peptide containing conjugates for dual molecular delivery of oligonucleotides
#8134Allele selective gene editing and uses thereof
#8135Carrier nanoparticles and related compositions, methods and systems
#8136COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
#8137Technology for the Preparation of Microparticles
#8138Individualized cancer therapy
#8139Nucleic acid fragment binding to target protein
#8140RNAi-Mediated Inhibition of Frizzled Related Protein-1 for Treatment of Glaucoma
#8141Treatment of Collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
#8142Compositions and Methods for Selective Delivery of Oligonucleotide Molecules to Cell Types
#8143Organic compositions to treat HSF1-related diseases
#8144TREATMENT OF MULTIPLE SCLEROSIS BY INHIBITION OF ALLOGRAFT INFLAMMATORY FACTOR-1
#8145Treatment for conditions associated with fibrosis and collagen deposition
#8146RNA sequence having anti-tumour activity
#8147CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
#8148COMPOSITIONS FOR MOSQUITO CONTROL AND USES OF SAME
#8149MiR-320e and colorectal cancer
#8150Methods for selecting competent oocytes and competent embryos with high potential for pregnancy outcome
#8151Invertebrate microRNAs
#8152RNA interference in dermal and fibrotic indications
#8153Skin and hair color-controlling factor
#8154Methods for preventing and treating chronic kidney disease (CKD)
#8155Antisense nucleic acids
#8156Targeting microRNAs for metabolic disorders
#8157RNA-interference by single-stranded RNA molecules
#8158MicroRNAs 206 and 21 cooperate to promote RAS-extracellular signal-regulated kinase signaling by suppressing the translation of RASA1 and SPRED1
#8159Antisense nucleic acids
#8160Modified cells and methods of therapy
#8161Reprogramming of human wharton's jelly cells to produce hair cells
#8162Metal-particle-based oral-administrating liver-specific nucleic acid delivery system and method of manufacturing the same
#8163Modified cells and methods of therapy
#8164Eukaryotic cells and methods for recombinantly expressing a product of interest
#8165Compounds and methods for CRISPR/Cas-based genome editing by homologous recombination
#8166COMPOSITIONS AND METHODS OF USING SAME FOR CONTROLLING PATHOGENICALLY INFECTED MOSQUITOES
#8167Compositions and methods for transport across the blood brain barrier
#8168Methods of treating autoimmune conditions in patients with genetic variations in DcR3 or in a DcR3 network gene
#8169Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#8170RNAi-mediated inhibition of phosphodiesterase type 4 for treatment of CAMP-related ocular disorders
#8171Methods for treating cancer using nucleic acids targeting MDM2 or MYCN
#8172METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
#8173COMPOSITIONS AND METHODS OF USING SAME FOR REDUCING RESISTANCE TO MOSQUITO LARVICIDES
#8174Manipulating microRNA for the management of neurological diseases or conditions and compositions related thereto
#8175RNA interference for the treatment of gain-of-function disorders
#8176EXTRACELLULAR VESICLE METHODS AND COMPOSITIONS
#8177Method and composition for diagnosis or treatment of aggressive prostate cancer
#8178Methods and compositions for inhibiting retinopathy of prematurity
#8179VASCULAR RE-MODELLING
#8180Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA
#8181ANTISENSE OLIGOMERS AND METHODS FOR TREATING SMN-RELATED PATHOLOGIES
#8182Compositions and methods of nucleic acid-targeting nucleic acids
#8183P97-polynucleotide conjugates
#8184Compositions and Methods for Identifying and Targeting Cancer Cells of Alimentary Canal Origin
#8185MULTIBLOCK COPOLYMERS
#8186Pharmaceutical combination comprising a CIP2A silencing agent for use in the treatment of a hyperproliferative disorder, preferably one with impaired P53 function
#8187Pdia4 protein as a target for diagnosis, monitoring and treatment of diabetes
#8188Targeting PARP1 for treatment of TSC and cancers
#8189Genetic alterations on chromosome 16 and methods of use thereof for the diagnosis and treatment of type 1 diabetes
#8190Recombinant RNA particles and methods of producing proteins
#8191Polycomb-associated non-coding RNAs
#8192OLIGONUCLEOTIDE SPECIFIC UPTAKE OF NANOCONJUGATES
#8193Compositions and methods to promote erythropoiesis
#8194Plant sRNA extract or plant miRNA for use as an immunosuppressive agent
#8195miRNAs Enhancing Cell Productivity
#8196SARNA COMPOSITIONS AND METHODS OF USE
#8197Oligomeric compounds comprising alpha-beta-constrained nucleic acid
#8198Compositions and Methods for Modulation of SMN2 Splicing in a Subject
#8199CRISPR-BASED COMPOSITIONS AND METHODS OF USE
#8200CRISPR-based compositions and methods of use
#8201CRISPR-based compositions and methods of use
#8202METHODS AND MEANS FOR EFFICIENT SKIPPING OF AT LEAST ONE OF THE FOLLOWING EXONS OF THE HUMAN DUCHENNE MUSCULAR DYSTROPHY GENE: 43, 46, 50-53
#8203Methods for the treatment of Leber congenital amaurosis
#8204Methods for producing enteroendocrine cells that make and secrete insulin
#8205Transposon Activation During Aging and Neuronal Decline
#8206tRNA derived small RNAs (tsRNAs) involved in cell viability
#8207Methods and Compositions to Modulate RNA Processing
#8208Crosslinked nucleoside and nucleotide
#82092′/3′/5′-(R/S)-serinyl functionalized oligonucleotides
#8210Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
#8211Antibodies and processes for preparing the same
#8212Bioactive conjugates for oligonucleotide delivery
#8213Compositions and methods for modulating stem cells and uses thereof
#8214Methods targeting miR-128 for regulating cholesterol/lipid metabolism
#8215LIPID NANO PARTICLES COMPRISING CATIONIC LIPID FOR DRUG DELIVERY SYSTEM
#8216NANOPARTICLES FOR TARGETED GENE THERAPY AND METHODS OF USE THEREOF
#8217NOVEL LIPID FORMULATIONS FOR NUCLEIC ACID DELIVERY
#8218In vivo Gene Engineering with Adenoviral Vectors
#8219Modulation of pre-MRNA using splice modulating oligonucleotides as therapeutic agents in the treatment of disease
#8220NEAT1 as a prognostic marker and therapeutic target for prostate cancer
#8221Pharmaceutical composition comprising Nanog shRNA, and method of using Nanog shRNA to treat cancer
#8222LncRNAs for therapy and diagnosis of angiogenesis
#8223METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#8224OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS
#8225Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#8226COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
#8227MODULATING IMMUNE RESPONSES
#8228Chiral design
#8229Artificial mimic miRNA for controlling gene expression, and use of same
#8230SPINAL MUSCULAR ATROPHY TREATMENT VIA TARGETING SMN2 CATALYTIC CORE
#8231Polycomb-associated non-coding RNAs
#8232VITAMIN E-BASED NANOCARRIERS FOR DRUG DELIVERY AND METHODS OF MAKING AND USING THE SAME
#8233Methods for treating and/or limiting development of diabetes
#8234Method and carrier complexes for delivering molecules to cells
#8235Sterile Emulsion Comprising a Stable Phosphorothioate Oligonucleotide
#8236Compositions and methods for making selenocysteine containing polypeptides
#8237CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING PRIMARY OPEN ANGLE GLAUCOMA
#8238Recombinant virus products and methods for inhibition of expression of DUX4
#8239Compositions and methods for controlling pests
#8240RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
#8241RNA modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy
#8242Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-associated diseases
#8243Multivalent oligonucleotide assemblies
#8244RNAi agents modified at the 4′-C position
#8245Agents useful in treating facioscapulohumeral muscular dystrophy
#8246Polycationic methyl phospholipids for improved delivery of nucleic acids to eukaryotic cells
#8247MultiLigand agent for drug delivery
#8248Specific and unique T cell responses and molecular signatures for the treatment and diagnosis of
#8249Biomarkers and therapeutic targets for abnormal retinal pigment epithelium
#8250Nucleic acid molecules to control insect pests
#8251Polycomb-associated non-coding RNAs
#8252Targeting molecule and a use thereof
#8253METHODS AND COMPOSITIONS FOR THE PRODUCTION OF GUIDE RNA
#8254METHOD OF REGULATING GENE EXPRESSION
#8255Polyconjugates for Delivery of RNAi triggers to Tumor Cells In Vivo
#8256Avian influenza virus miRNA, and appraisal, detection, and application thereof
#8257REDUCTION OF OFF-TARGET RNA INTERFERENCE TOXICITY
#8258Asymmetric bifunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents
#8259Combination therapy for the treatment of autoimmune diseases
#8260Compositions and methods for nanoparticle lyophile forms
#8261PRP8 NUCLEIC ACID MOLECULES TO CONTROL INSECT PESTS
#8262SNAP25 NUCLEIC ACID MOLECULES TO CONTROL INSECT PESTS
#8263Composition for promoting chondrocyte differentiation or treating cartilage diseases, containing KLF10 expression inhibitor, and method for promoting cartilage differentiation by using same
#8264Method of Treating Cancer by Inhibition of DNA Repair Proteins
#8265COMPOSITIONS AND METHODS FOR TREATMENT OF OVARIAN CANCER
#8266Low molecular weight cationic lipids for oligonucleotide delivery
#8267Dual targeting antisense oligonucleotides as apoptotic inhibtor therapeutic compostions and methods for their use in the treatment of cancer
#8268Compositions and methods for treating cachexia
#8269Compositions and methods for modulation of SMN2 splicing in a subject
#8270Plants with useful traits and related methods
#8271MicroRNA expression in human peripheral blood microvesicles and uses thereof
#8272Regulatory polynucleotides and uses thereof
#8273RNA interference in skin indications
#8274RNAi-mediated inhibition of connexin 43 for treatment of IOP-related conditions
#8275ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#8276ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#8277Compositions and methods for inhibition of nucleic acids function
#8278Methods used to treat cancer
#8279COMPOSITIONS FOR INHIBITING DUX4 GENE EXPRESSION AND USES THEREOF
#8280Inhibition of NEAT1 for treatment of solid tumors
#8281BIOLOGICAL MATERIALS AND THERAPEUTIC USES THEREOF
#8282DOWNREGULATION OF miR-7 FOR PROMOTION OF BETA CELL DIFFERENTIATION AND INSULIN PRODUCTION
#8283Trialkyl cationic lipids and methods of use thereof
#8284Compositions and methods for treating diabetes
#8285Methods of using an activator of cereblon for neural cell expansion and the treatment of central nervous system disorders
#8286Multi-targeting short interfering RNAs
#8287Synthetic genes and genetic constructs
#8288Modulation of prekallikrein (PKK) expression
#8289Method for treatment of heart failure
#8290MiRNA modulators of thermogenesis
#8291Methods and Compositions Related To miR-21 and miR-29A, Exosome Inhibition And Cancer Metastasis
#8292Inhibitors of thioredoxin-interacting protein (TXNIP) for therapy
#8293Compositions and methods for reducing C/EBP homologous protein activity in myeloid-derived suppressor cells
#8294TAILED MIRTRON EFFECTORS FOR RNAI-MEDIATED GENE SILENCING
#8295SMALL RNA, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN PHARMACEUTICALS FOR SPECIFICALLY UP-REGULATING GENE TRANSCRIPTIONAL ACTIVITY
#8296Micrornas that silence tau expression
#8297Eukaryotic cells and methods for recombinantly expressing a product of interest
#8298Compounds for targeting drug delivery and enhancing siRNA activity
#8299Compounds for targeting drug delivery and enhancing siRNA activity
#8300Methods and Compositions for Inhibiting Mitochondrial Trafficking
#8301Identification and use of target genes for control of plant parasitic nematodes
#8302Polycomb-associated non-coding RNAS
#8303Methods of Manipulating the Fate of Cells
#8304iRNA agents with biocleavable tethers
#8305Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#8306Micro-RNA inhibitor
#8307Molecular re-engineering of excitation-inhibition balance in memory circuits
#8308Functionally-modified oligonucleotides and subunits thereof
#8309Nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction method of RNA interferencde in eukaryotic host and use of the nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide CAG repeats
#8310Oligonucleotide-ligand conjugates and process for their preparation
#8311Adeno-associated virus virions with variant capsid and methods of use thereof
#8312Biocompatible flavonoid compounds for organelle and cell imaging
#8313Lipids and lipid nanoparticle formulations for delivery of nucleic acids
#8314Adeno-associated virus virions with variant capsid and methods of use thereof
#8315MIKTO-ARM BRANCHED POLYMERS
#8316TYROSINE-PHOSPHORYLATED WBP2, A NOVEL CANCER TARGET AND BIOMARKER
#8317Parental RNAI suppression of kruppel gene to control hemipteran pests
#8318COMPOSITIONS FOR BACTERIAL MEDIATED GENE SILENCING AND METHODS OF USING SAME
#8319Double-stranded and single-stranded RNA molecules with 5′ triphosphates and their use for inducing interferon
#8320RNAi targeting CNTD2
#8321Antisense polynucleotides to induce exon skipping and methods of treating dystrophies
#8322RNAi targeting ZNF205
#8323Modulation of transthyretin expression
#8324THERAPEUTIC AND DIAGNOSTIC STRATEGIES
#8325Compositions and their uses directed to huntingtin
#8326COMPOSITIONS AND METHODS FOR DELIVERING MICRORNA
#8327METHODS OF USING STRUCTURALLY INTERACTING RNA
#8328Inhibition of microRNA-134 for the treatment of seizure-related disorders and neurologic injuries
#8329Polycation-functionalized nanoporous silicon carrier for systemic delivery of gene silencing agents
#8330Compositions for in vivo expression of therapeutic sequences in the microbiome
#8331Molecular marker for cancer stem cell
#8332Methods and compositions for neuroprotection
#8333Polynucleotides and methods for inhibiting cancer cells
#8334DIFFERENTIALLY EXPRESSED MICRORNA MOLECULES FOR THE TREATMENT AND DIAGNOSIS OF CANCER
#8335COMPOSITIONS AND METHODS OF USING MICRORNA INHIBITORS
#8336Methods and compositions for modulating alpha-1 antitrypsin expression
#8337COMPOSITION INCLUDING RCC1-REGULATING SUBSTANCE FOR REDUCING SENESCENCE OF CELL OR SUBJECT AND METHOD OF REDUCING SENESCENCE OF CELL OR SUBJECT BY USING THE COMPOSITION
#8338In vivo production of small interfering RNAs that mediate gene silencing
#8339COMPOSITIONS AND METHODS OF MODULATING B CELL RESPONSE
#8340Therapeutic targets for cancer progression
#8341KIDNEY DISEASE TARGETS AND USES THEREOF
#8342TREATMENT OF CARDIAC DISEASES WITH MODULATORS OF THE HIPPO PATHWAY
#8343METHODS FOR CATEGORISING CANCER SUCH AS BREAST CANCER
#8344Treatment of disease by modulation of SIRT6
#8345Control of Varroa mite infestation
#8346Potent LNA oligonucleotides for the inhibition of HIF-1A expression
#8347METHOD OF FIXING AND EXPRESSING PHYSIOLOGICALLY ACTIVE SUBSTANCE
#8348RNAi agents, compositions and methods of use thereof for treating transthyretin (TTR) associated diseases
#8349PROKARYOTIC RNAi-LIKE SYSTEM AND METHODS OF USE
#8350miR-29 mimics and uses thereof
#8351miR-155 inhibitors for treating cutaneous T cell lymphoma (CTCL)
#8352Polycomb-associated non-coding RNAs
#8353Compositions and methods for treating liver injury
#8354Antisense oligonucleotides for treatment of spinal muscular atrophy
#8355Modulation of Exon Recognition in Pre-mRNA By Interfering with the Secondary RNA Structure
#8356MicroRNA-Based Methods and Assays for Osteosarcoma
#8357Oligonucleotide compounds for targeting huntingtin mRNA
#8358THERAPEUTIC AND DIAGNOSTIC MOLECULES
#8359Polycomb-associated non-coding RNAs
#8360Double stranded oligonucleotide compounds comprising positional modifications
#8361MODULATION OF MICRORNA-138 FOR THE TREATMENT OF BONE LOSS
#8362Systems, methods and compositions for sequence manipulation with optimized functional CRISPR-Cas systems
#8363Compositions and methods of use of CRISPR-Cas systems in nucleotide repeat disorders
#8364COMPOSITIONS AND METHODS OF USE OF CRISPR-CAS SYSTEMS IN NUCLEOTIDE REPEAT DISORDERS
#8365Anionic polyplexes for use in the delivery of nucleic acids
#8366Compositions and methods for modulating an immune response
#8367Hybridosomes, compositions comprising the same, processes for their production and uses thereof
#8368Detection of nucleic acids
#8369SPT5 NUCLEIC ACID MOLECULES TO CONTROL INSECT PESTS
#8370Antisense design
#8371NUCLEIC ACID CHEMICAL MODIFICATIONS
#8372POST-SYNTHETIC CHEMICAL MODIFICATION OF RNA AT THE 2'-POSITION OF THE RIBOSE RING VIA "CLICK" CHEMISTRY
#8373Ribozyme with tRNA synthetase activity and methods of manufacturing and using the same
#8374Compositions and methods for inhibiting gene expression of Hif2alpha
#8375Alternative export pathways for vector expressed RNA interference
#8376Compounds of chemically modified oligonucleotides and methods of use thereof
#8377Modulation of signal transducer and activator of transcription 3 (STAT3) expression
#8378Oligonucleotides and Methods for Treatment of Cardiomyopathy Using RNA Interference
#8379Oligonucleotides and methods for inhibiting or reducing bacterial biofilms
#8380Micro-RNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions
#8381MODULATION OF TRANSTHYRETIN EXPRESSION
#8382LONG NON-CODING RNA SPRY4-IT1 AS A DIAGNOSTIC AND THERAPEUTIC AGENT
#8383Nanoscale carriers for the delivery or co-delivery of chemotherapeutics, nucleic acids and photosensitizers
#8384SCREENING FOR TARGET-SPECIFIC AFFINITY BINDERS
#8385miR-211 expression and related pathways in human melanoma
#8386Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#8387MICRORNA MODULATION OF ARTHEROSCLEROSIS AND USES THEREOF
#8388Compositions and Methods to Inhibit EZH2 for the Treatment of Cardiovascular Diseases
#8389Methods for the prevention and the treatment of extracapillary glomerulonephritis
#8390Clonal analysis of functional genomic assays and compositions for practicing same
#8391Delivery of packaged RNA to mammalian cells
#8392Multimeric Complexes with Improved in Vivo Stability, Pharmacokinetics and Efficacy
#8393In vitro method for identifying compounds of the Nav 1.9 sodium channel intended for the treatment of an inflammatory skin disease
#8394CANCER TARGETS AND USES THEREOF
#8395Compositions and methods for treating autoimmune and inflammatory diseases
#8396Metabolism-based drug screening platform in bioengineered zebrafish
#8397Enhancing endonuclease based gene editing in primary cells
#8398MiRNA for treating diseases and conditions associated with neo-angiogenesis
#83995′ triphosphate oligonucleotide with blunt end and uses thereof
#8400Altering microbial populations and modifying microbiota