109048 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Methods and compositions for preventing or reducing infections of crop plants by bacterial and fungal pathogens
#7802COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
#7803MODULATION OF APOLIPOPROTEIN CIII (APOCIII) EXPRESSION
#7804Methods of Inducing Exon Skipping
#7805Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#7806RNAS WITH TUMOR RADIO/CHEMO-SENSITIZING AND IMMUNOMODULATORY PROPERTIES AND METHODS OF THEIR PREPARATION AND APPLICATION
#7807ANTISENSE COMPOUNDS AND USES THEREOF
#7808Next generation RNA-sequencing and long non-coding RNA in glioblastoma multiforme
#7809Repressor on IFN-λ promoter and siRNA against GATA1, EVI1, and CRX to alter IFN-λ gene activity
#7810POLYNUCLEOTIDES AND POLYPEPTIDE SEQUENCES INVOLVED IN THE PROCESS OF BONE REMODELING
#7811Delivery of dsRNA to arthropods
#7812Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof
#7813Modified antimir-138 oligonucleotides
#7814Methods of treating, inhibiting and/or preventing an auditory impairment
#7815Tricyclo-DNA antisense oligonucleotides, compositions, and methods for the treatment of disease
#7816NON-LIPOSOMAL SYSTEMS FOR NUCLEIC ACID DELIVERY
#7817Compositions and methods for controlling insect pests
#7818Methods of inhibiting pathological angiogenesis with doppel-targeting molecules
#7819Ruthenium-based photolinkers and methods of use
#7820Exosome transfer of nucleic acids to cells
#7821Bacterially derived intact minicells that encompass plasmid free DNA and methods of using the same
#7822COMPOSITIONS AND METHODS TO CONTROL INSECT PESTS
#7823Antisense oligonucleotides (ODN) against Smad7 and uses thereof in medical field
#7824Allele-specific therapy for huntington disease haplotypes
#7825Transcriptome in vivo analysis (TIVA) and transcriptome in situ analysis (TISA)
#7826Targeting ligands for therapeutic compounds
#7827COMPLEMENT COMPONENT C5 IRNA COMPOSITIONS AND METHODS OF USE THEREOF
#7828Polypeptide inhibitors of Smad3 polypeptide activities
#7829Self-cleaving ribozymes and uses thereof
#7830Antibodies that recognize a DENN/MADD-domain-containing 1A variant 2 (DENND1A variant 2)
#7831Method of predicting obesity comprising measuring neurotensin
#7832ANTI-CANCER AGENT SENSITIVITY-DETERMINING MARKER
#7833COMPOSITIONS, METHODS AND USE OF SYNTHETIC LETHAL SCREENING
#7834MicroRNA biomarkers for posttraumatic stress disorder and methods of use thereof
#7835Methods and compositions for root knot nematode control
#7836Methods, systems, and compositions for cell-derived/vesicle-based microRNA delivery
#7837Interfering RNA molecules
#7838NUCLEIC ACID CAPABLE OF INHIBITING EXPRESSION OF BETA-2GPI
#7839NUCLEIC ACID CAPABLE OF INHIBITING EXPRESSION OF BETA-2GPI
#7840Artificial nucleic acid molecules for improved protein or peptide expression
#7841Interfering RNA molecules
#7842Interfering RNA molecules
#7843MICRORNA WITH PLACENTA-PERMEABILITY AND USES THEREOF
#7844ISOTOPOLOGUES OF SMAD7 ANTISENSE OLIGONUCLEOTIDES
#7845Oligonucleotide decoys for the treatment of pain
#7846COMBINATORIAL TREATMENT OF CHEMOTHERAPY AND ARMED VIRUSES TARGETING TUMOR
#7847COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS
#7848Method for efficient delivery of therapeutic molecules in vitro and in vivo
#7849Antibacterial antisense oligonucleotide and method
#7850Edible Plants Producing Bioengineered Micro-RNA for Gene Regulation Upon Ingestion
#7851Altering microbial populations and modifying microbiota
#7852COMPOSITIONS AND METHODS TO CONTROL INSECT PESTS
#7853Treatment and biomarker for pulmonary hypoplasia in congenital diaphragmatic hernia
#7854SCN8A splice modulating oligonucleotides and methods of use thereof
#7855Modulation of breast cancer growth by modulation of XBP1 activity
#7856Method for inhibiting Ebola virus via miRNA
#7857Antiviral agent comprising RNA oligonucleotide
#7858Nucleic acid compositions related to MIR-138-1-3P and uses thereof
#7859Methods and compositions for treating a subject with a SMAD7 antisense oligonucleotide
#7860Polynucleotide agents targeting Serpinc1 (AT3) and methods of use thereof
#7861MicroRNA compounds and methods for modulating miR-21 activity
#7862GNAQ targeted dsRNA compositions and methods for inhibiting expression
#7863DNA-RNA hybrid particles and manufacturing method thereof
#7864Reduction of amyloid beta peptide production via modification of the APP gene using the CRISPR/Cas system
#7865Magnetic control of gene delivery in vivo
#7866Antibody-siRNA conjugates and uses therefor
#7867Small molecule inhibitors of RNA binding motif (RBM) proteins for the treatment of acute cellular injury
#7868SCAFFOLD RNAS
#7869Compositions for controlling mites in bees
#7870METHODS FOR DOSING AND MONITORING SMAD7 ANTISENSE OLIGONUCLEOTIDE TREATMENT USING BIOMARKER LEVELS
#7871Allele selective inhibition of mutant C9orf72 foci expression by duplex RNAS targeting the expanded hexanucleotide repeat
#7872NUCLEIC ACID LIPID PARTICLE FORMULATIONS
#7873Twist signaling inhibitor compositions and methods of using the same
#7874MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS
#7875Tetragalnac containing conjugates and methods for delivery of oligonucleotides
#7876REGULATION OF MIR-33 MICRORNAS IN THE TREATMENT OF CHOLESTEROL-RELATED DISORDERS
#7877POROUS NANOPARTICLE-SUPPORTED LIPID BILAYERS (PROTOCELLS) FOR TARGETED DELIVERY INCLUDING TRANSDERMAL DELIVERY OF CARGO AND METHODS THEREOF
#7878METHODS FOR ISOLATING ENDOGENOUS NUCLEIC ACIDS FROM SUBCELLULAR COMPARTMENTS WITHOUT FRACTIONATION
#7879INHIBITORY RNA FOR ENHANCED PROTEIN PRODUCTION IN RECOMBINANT MAMMALIAN CELLS
#7880Antisense oligonucleotide directed removal of proteolytic cleavage sites, the HCHWA-D mutation, and trinucleotide repeat expansions
#7881MICRORNAS AND USES THEREOF
#7882Method for modulating plant processes
#7883Therapeutic or prophylactic composition for TDP-43 proteinopathy
#7884COORDINATE CONTROL OF PATHOGENIC SIGNALING BY THE MIR-130/301 FAMILY IN PULMONARY HYPERTENSION AND FIBROPROLIFERATIVE DISEASES
#7885MODULATION OF ENHANCER RNA MEDIATED GENE EXPRESSION
#7886Method for improving memory using CCNY inhibitor
#7887PANCREATIC CANCER TARGETS AND USES THEREOF
#7888Algae and method for producing same, and method for producing biomass using said algae
#7889GAWKY (GW) NUCLEIC ACID MOLECULES TO CONTROL INSECT PESTS
#7890RPB7 NUCLEIC ACID MOLECULES TO CONTROL INSECT PESTS
#7891Methods for preparing pecific polypeptide-binding antibodies
#7892Compositions and methods to treating hemoglobinopathies
#7893MicroRNA compounds and methods for modulating miR-122
#7894Methods and materials for activating an internal ribosome entry site in exon 5 of the DMD gene
#7895METHODS FOR MALIGNANT TUMORS WITH RNAI MOLECULES TARGETED TO HSP47
#7896miR-96-5p inhibitor and a screening method for the inhibitor
#7897MORPHOLINO-MEDIATED INCREASE IN SOLUBLE FLT-1 EXPRESSION RESULTS IN DECREASED OCULAR AND TUMOR NEOVASCULARIZATION
#7898Composition and method of using miR-302 precursors as drugs for treating Alzheimer's diseases
#7899Morpholino oligonucleotide manufacturing method
#7900Crispr enzymes and systems
#7901Treatment of brain derived neurotrophic factor (BDNF) related diseases by inhibition of natural antisense transcript to BDNF
#7902Methods and Compositions for the Treatment of Prostate Related Disorders using miR-106b
#7903Multimetric oligonucleotide compounds
#7904COMPOSITIONS AND METHODS FOR MODULATING TAU EXPRESSION
#7905METHOD FOR IMPROVED HIGH-LEVEL SECRETORY PRODUCTION OF PROTEIN
#7906Antisense oligonucleotide compositions
#7907ENHANCED REPROGRAMMING TO IPS CELLS
#7908Honey bee mite disruptive compounds and methods of application
#7909Compositions comprising riboregulators and methods of use thereof
#7910USE OF H2A.Z.1 AS A HEPATOCELLULAR CARCINOMA BIOMARKER
#7911METHODS FOR OPTIMIZING ELECTROPORATION
#7912Method for controlling obesity using minimally invasive means
#7913Oligonucleotide comprising an inosine for treating DMD
#7914Oligomers
#7915Modifications for antisense compounds
#7916Methods and compositions for treating insects
#7917Antisense nucleic acids
#7918Method for controlling obesity using minimally invasive means
#7919Compositions for Targeted Delivery of siRNA
#7920Methods of using engineered nucleic-acid targeting nucleic acids
#7921Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells
#7922SYNTHESIS AND USE OF AMINO LIPIDS
#7923TERMINAL MODIFICATIONS OF POLYNUCLEOTIDES
#7924Methods of inhibiting cancer stem cells with HMGA1 inhibitors
#7925Rotationally sequestered translators
#7926R2R1/2 in diagnosis and therapy
#7927METHODS OF GLUCOCORTICOID THERAPY AND DETERMINING RESPONSIVENESS THEREOF
#7928Preventive or therapeutic agent for fibrosis
#7929ANTI-INFLAMMATORY TREATMENT VIA INHIBITION OF ENDOTHELIAL CELL KINESIN LIGHT CHAIN 1, VARIANT 1 (KLC1C)
#7930Targeting microRNAs for the treatment of fibrosis
#7931Targeting human satellite II (HSATII)
#7932Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups
#7933Programmable RNA shredding by the type III-A CRISPR-Cas system of
#7934HCBI, MSBI, MSSI AND CMI SEQUENCES AS AN EARLY MARKER FOR THE FUTURE DEVELOPMENT OF CANCER AND DISEASES OF THE CNS AND AS A TARGET FOR THE TREATMENT AND PREVENTION OF THESE DISEASES
#7935Cationic lipid
#7936Lung cancer adjuvant therapy
#7937Method of encapsulating a nucleic acid in a lipid nanoparticle host
#7938Non-CRISPR-mediated phage resistant
#7939Altering microbial populations and modifying microbiota
#7940Biomarkers for human monocyte myeloid-derived suppresor cells
#7941Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
#7942Solid Phase Transfection of Proteins and Nucleic Acids
#7943CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
#7944COMPOSITIONS AND METHODS OF USING SAME FOR INCREASING RESISTANCE OF INFECTED MOSQUITOES
#7945Oligonucleotides for inducing paternal UBE3A expression
#7946PERFORIN 2 DEFENSE AGAINST INVASIVE AND MULTIDRUG RESISTANT PATHOGENS
#7947RNA EDITING BIOMARKERS FOR DIAGNOSIS, PHARMACOLOGICAL SCREENING AND PROGNOSTICATION IN CANCER
#7948Recombinant AAVS having useful transcytosis properties
#7949Angiotensinogen (AGT) iRNA compositions and methods of use thereof
#7950NOVEL MESENCHYMAL STEM CELL SURFACE MARKER
#7951DD1ALPHA RECEPTOR AND USES THEREOF IN IMMUNE DISORDERS
#7952Compositions and methods for controlling
#7953ENHANCEMENT OF PLANT YIELD VIGOR AND STRESS TOLERANCE
#7954PLANTS WITH IMPROVED AGRONOMIC TRAITS
#7955SMALL RNAs (sRNA) THAT ACTIVATE TRANSCRIPTION
#7956Polynucleotide agents targeting complement component C5 and methods of use thereof
#7957Use of miR-199a-5p, targets and/or inhibitors thereof for the diagnosis, prognosis and treatment of fibroproliferative disorders
#7958Method of separating senescent cells using overexpression of protocadherin
#7959Composition including pint gene expression inhibitor or pint activity inhibitor and use thereof
#7960Compositions and uses for treatment thereof
#7961DNA recombinase circuits for logical control of gene expression
#7962Pri-mirna libraries and methods for making and using pri-mirna libraries
#7963LNCRNAS FOR THERAPY AND DIAGNOSIS OF CARDIAC HYPERTROPHY
#7964High-yield method for rapidly conjugating ribonucleic acid (RNA) to diethylenetriamine pentaacetic acid (DTPA)
#7965PHARMACEUTICAL COMPOSITIONS COMPRISING RNA AND USE FOR TREATING CANCER
#7966Ref nuclease for site specific Ref-mediated DNA cleavage
#7967Methods of inhibiting pathological angiogenesis with doppel-targeting molecules
#7968Composition for delivery of genetic material
#7969Delivery of agents using interfering nanoparticles
#7970Antisense compounds
#7971Retroviral vector having immune-stimulating activity
#7972Genomic insulator elements and uses thereof
#7973COMPOSITIONS AND METHODS FOR THE SUPPRESSION OF TARGET POLYNUCLEOTIDES FROM LEPIDOPTERA
#7974Ribosomal protein L40 (RPL40) nucleic acid molecules that confer resistance to coleopteran and hemipteran pests
#7975CRISPR-CAS-RELATED METHODS, COMPOSITIONS AND COMPONENTS FOR CANCER IMMUNOTHERAPY
#7976Methods of controlling cell fate and consequences for disease
#7977Lepidopteran moth control using double-stranded RNA constructs
#7978Composition and method of using miR-302 precursors as anti-cancer drugs for treating human lung cancer
#7979Antisense oligonucleotide directed removal of proteolytic cleavage sites from proteins
#7980Compositions and methods for decreasing tau expression
#7981Method for treating fibrosis using siRNA and a retinoid-lipid drug carrier
#7982Compositions for modulating Ataxin 2 expression
#7983Methods for modulating Ataxin 2 expression
#7984MIR-21-3P INHIBITORS IN SKIN DISORDERS
#7985Gene therapy for retinitis pigmentosa
#7986Drug delivery particle and method for producing the same
#7987LONG NON-CODING RNA AS A DIAGNOSTIC AND THERAPEUTIC AGENT
#7988Isolation of novel AAV's and uses thereof
#7989Targeting peptides for directing adeno-associated viruses (AAVs)
#7990Recombinant AAV vectors useful for reducing immunity against transgene products
#7991PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS
#7992Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#7993Methods for the treatment of cardiovascular fibrosis
#7994METHODS OF TREATING A METABOLIC SYNDROME BY MODULATING HEAT SHOCK PROTEIN (HSP) 90-BETA
#7995Isolation of novel AAV's and uses thereof
#7996Methods and compositions for treating malignant tumors associated with kras mutation
#7997COMPOSITION OF LIPID-BASED NANOPARTICLES FOR SMALL MOLECULES AND MACROMOLECULES
#7998Micrornas as new therapeutic targets for the prevention and/or treatment of retinopathy
#7999Engineered nucleic acid-targeting nucleic acids
#8000RAAV-BASED COMPOSITIONS AND METHODS FOR TREATING ALPHA-1 ANTI-TRYPSIN DEFICIENCIES
#8001GENERATION OF ARTIFICIAL MICRORNAS
#8002Compositions and methods for modulating complement factor B expression
#8003Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#8004Methods and compositions for treating a Serpinc1-associated disorder
#8005Antisense oligonucleotides for the treatment of Usher syndrome type 2
#8006Small interfering RNA and pharmaceutical composition and method for inhibiting galectin-12 expression and/or enhancing lipolysis containing the same
#8007SPLICE-REGION ANTISENSE COMPOSITION AND METHOD
#8008COMPOSABILITY AND DESIGN OF PARTS FOR LARGE-SCALE PATHWAY ENGINEERING IN YEAST
#8009Medical devices for delivery of siRNA
#8010Methods of treating fragile X syndrome and related disorders
#8011Composition, kit, and method for diagnosing and treating ovarian cancer
#8012Method of producing lipid nanoparticles for drug delivery
#8013Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1
#8014Methods for triggering de novo formation of heterochromatin and or epigenetic silencing with small RNAS
#8015Modulation of BCL11A for treatment of hemoglobinopathies
#8016Nanoparticle type oligonucleotide structure having high efficiency and method for preparing same
#80175' TARGETING OLIGONUCLEOTIDES FOR MODULATING RNA
#8018LIPID PARTICLES WITH CATIONIC LIPIDS FOR RNA DELIVERY
#8019Cell lines for virus production and methods of use
#8020Structuring fats and methods of producing structuring fats
#8021Multicistronic expression constructs
#8022Modular construction of synthetic gene circuits in mammalian cells using TALE transcriptional repressors
#8023COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL ABSORPTION OF CONJUGATED OLIGOMERIC COMPOUNDS
#8024Transferrin/transferrin receptor-mediated siRNA delivery
#8025Treatment of Frataxin (FXN) related diseases by inhibition of natural antisense transcript to FXN
#8026Cancer treatment
#8027COMPOSITIONS FOR INHIBITING NLRP3 GENE EXPRESSION AND USES THEREOF
#8028Treatment of nuclear factor (erythroid-derived 2)-like 2 (NRF2) related diseases by inhibition of natural antisense transcript to NRF2
#8029Purification of triphosphorylated oligonucleotides using capture tags
#8030Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
#8031Ionizable cationic lipid for RNA delivery
#8032Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof
#8033NANOCOMPOSITES OF GOLD AND POLYMERS
#8034LIPID FORMULATION
#8035Compositions and methods for treating ewing sarcoma
#8036Double strand RNA-mediated RNA interference through feeding detrimental to larval (gypsy moth)
#8037Treatment of age-related macular degeneration using RNA complexes that target MYD88 or TLR3
#8038Apoptosis inducer
#8039Double-stranded oligonucleotides
#8040NOVEL SINGLE CHEMICAL ENTITIES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES
#8041Organic compositions to treat APOC3-related diseases
#8042miRNAs as novel therapeutic targets and diagnostic biomarkers for parkinson's disease
#8043COMPOSITIONS AND METHODS FOR MODULATING MYELOID DERIVED SUPPRESSOR CELLS
#8044Targeting microRNAS for the treatment of liver cancer
#8045Nucleic acid drug for inducing skipping of variant exon of CD44 gene and increasing expression of normal type CD44 mRNA
#8046Nucleic acid functionalized nanoparticles for therapeutic applications
#8047IMPROVED SMALL INTERFERING RIBONUCLEIC ACID MOLECULES
#8048Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
#8049Pharmaceutical composition and uses thereof
#8050Colorectal cancer detection kit or device, and detection method
#8051Trans-acting elements for intracellular delivery of nucleic acid sequences
#8052SHIBIRE/DYNAMIN NUCLEIC ACID MOLECULES TO CONTROL COLEOPTERAN AND HEMIPTERAN PESTS
#8053Method for fine-tuning gene expression levels using synthetic regulatory SRNA
#8054Double-stranded oligo RNA targeted to amphiregulin and pharmaceutical composition comprising same for preventing or treating fibrosis or respiratory diseases
#8055Modified oligonucleotides for telomerase inhibition
#8056LINKAGE MODIFIED GAPPED OLIGOMERIC COMPOUNDS AND USES THEREOF
#8057Replication factor C-40 (RFC40/RFC2) as a prognostic marker and target in estrogen positive and negative and triple negative breast cancer
#8058Small molecules that enhance the activity of oligonucleotides
#8059Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA
#8060Intracellular genomic transplant and methods of therapy
#8061Peptide sequence design and use thereof for peptide-mediated siRNA delivery
#8062Drug introducing agent for administration into a living body and manufacturing method
#8063Liposomal formulations for delivery of nucleic acids
#8064Biomarkers and treatments for heart failure
#8065Algal mutants with increased lipid productivity
#8066METHOD FOR PRODUCING LIPID PARTICLES AND NUCLEIC ACID DELIVERY CARRIER HAVING LIPID PARTICLES
#8067METHOD OF TREATING HYPERLIPIDEMIA AND ATHEROSCLEROSIS WITH MIR-30C
#8068NUCLEIC ACID-CONTAINING LIPID PARTICLES AND RELATED METHODS
#8069miRNAs useful for identifying targets associated with cancer
#8070Methods and compositions for modulating apolipoprotein (a) expression
#8071Compositions and Methods for Inhibiting Expression of Factor V
#8072Multifunctional RNA nanoparticles and methods of use
#8073Pharmaceutical use of FAM19A5 involved in regulating gliogenesis
#8074Inhibitors of metastasis
#8075Peptide, complex of peptide and siRNA and use thereof
#8076REFILLABLE DRUG DELIVERY DEVICES AND METHODS OF USE THEREOF
#8077Lipid particles and nucleic acid delivery carrier
#8078Method for treating kidney disease with a SLIT2-binding extracellular domain of ROBO2
#8079Method for expression of small RNA molecules within a cell
#8080Serpina1 iRNA compositions and methods of use thereof
#8081POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS
#8082RAAV-based compositions and methods for treating amyotrophic lateral sclerosis
#8083RNA Modification to Engineer Cas9 Activity
#8084SLIT-ROBO-Myo9-RHOA PATHWAY AND CANCER
#8085Enhanced productivity by attenuation of chlorophyll binding protein genes
#8086Ionizable cationic lipid for RNA delivery
#8087Delivery of hydrophobic active agent particles
#8088CELL DELIVERY SYSTEM AND METHOD
#8089All sterile males of culicine mosquitoes: a method of creation
#8090Virus-resistant tobacco and method for creating same
#8091Antisense compositions and methods of making and using same
#8092RNA MOLECULES AND USES THEREOF
#8093Monomers and oligonucleotides comprising cycloaddition adduct(s)
#8094METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA
#8095Oligonucleotide end caps
#8096Transmission blocking vaccines for mosquito-borne
#8097p-Ethoxy nucleic acids for liposomal formulation
#8098Methods For Treating Nicotinic Acetylcholine Receptor Associated Diseases
#8099Modulation of gene expression and screening for deregulated protein expression
#8100RNAi PHARMACEUTICAL COMPOSITION FOR SUPPRESSING EXPRESSION OF CKAP5 GENE