109048 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Treatment of staphylococcal disorders
#9002Vectors for delivery of agents across biological membranes
#9003Fatty acids and their use in conjugation to biomolecules
#9004Therapeutic agent for fibroid lung
#9005Methods of using ZSCAN4 for rejuvenating human cells
#9006Methods and compositions for weed control
#9007Methods and compositions related to T-cell activity
#9008FALZ for use as a target for therapies to treat cancer
#9009Sequence specific antimicrobials
#9010Therapeutic alteration of transplantable tissues through in situ or ex vivo exposure to RNA interference molecules
#9011Treatment of LCAT gene related diseases by inhibition of a natural antisense transcript to LCAT
#9012Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene
#9013TREATING TH2-MEDIATED DISEASES BY INHIBITION OF BROMODOMAINS
#9014miRNA BIOGENESIS IN EXOSOMES FOR DIAGNOSIS AND THERAPY
#9015Recombinant polypeptide production
#9016Methods for including cardiomyocyte proliferation
#9017Oligomers
#9018Compositions and methods for inhibition of expression of protein C (PROC) genes
#9019Methods for increasing efficacy of lipid formulated siRNA
#9020Compositions And Methods For Inhibiting Expression Of GSK-3 Genes
#9021Methods for monitoring C9ORF72 expression
#9022LNA antisense oligonucleotides for the modulation of Myc expression
#9023MiR-204 and miR-211 and uses thereof
#9024miRNA for treating cancer and for use with adoptive immunotherapies
#9025Polypeptide based block copolymer and the process for the preparation thereof, and the polymer micelles using the same
#9026SAB as a Biomarker for Degenerative Diseases and Therapeutic Sensitivity in Cancers
#9027Method for treating muscle-invasive bladder cancer, containing S100A9 and EGFR inhibitors and cisplatin as active ingredients
#9028MiRNA molecule defined by its source and its diagnostic and therapeutic uses in diseases or conditions associated with EMT
#9029Targeting microRNA miR-409-3P to treat prostate cancer
#9030Serpinc1 iRNA compositions and methods of use thereof
#9031Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#9032DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#9033PHOSPHORODIAMIDATE MORPHOLINO OLIGOMERS (PMOS) AND THEIR USE IN SUPPRESSION OF MUTANT HUNTINGTIN EXPRESSION AND ATTENUATION OF NEUROTOXICITY
#9034MICRORNAS AS FUNCTIONAL MEDIATORS AND BIOMARKERS OF BONE METASTASIS
#9035Lipohillic oligonucleotide analogs
#9036CHIMERIC OLIGOMERIC COMPOUNDS AND THEIR USE IN GENE MODULATION
#9037CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE
#9038Reducing intron retention
#9039Method for expressing, secreting and transferring functional microRNAs/siRNAs and application thereof
#9040Selective targeting of cancer stem cells
#9041METHODS OF INCREASING INSULIN CONTENT IN CELLS
#9042Lipid-Coated Albumin Nanoparticle Compositions and Methods of Making and Method of Using the Same
#9043Method for enhancing a function of a T cell
#9044Activation of innate immunity by miRNA for cancer and infection treatment
#9045Methods and compositions for weed control
#9046METHODS TO PREDICT AND PREVENT RESISTANCE TO TAXOID COMPOUNDS
#9047Treatment of tristetraproline (TTP) related diseases by inhibition of natural antisense transcript to TTP
#9048Locked nucleic acid inhibitor of miR-145 and uses thereof
#9049Bridged bicyclic nucleosides
#9050Organic compositions to treat EPAS1-related diseases
#9051Method for inhibiting tumor growth through RNA-interference using liposomally associated CDC20 siRNA
#9052Method for treating and/or preventing myopia
#9053OLIGOMERIC COMPOUNDS AND EXCIPIENTS
#9054Biodegradable lipids for the delivery of active agents
#9055Vectors and methods for genetic immunization
#9056Immunomodulation by controlling expression levels of microRNAs in dendritic cells
#9057Cell-penetrating oligonucleotides
#9058Tetrary gene delivery system for gene therapy and methods of its use
#9059MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF DISEASES ASSOCIATED WITH EPITHELIAL MESENCHYMAL TRANSITION
#9060Methods for co-silencing expression of genes in filamentous fungal strains and uses thereof
#9061Compositions And Methods To Enhance Protein Expression
#9062RNAi-mediated inhibition of connexin 43 for treatment of IOP-related conditions
#9063Multiple exon skipping compositions for DMD
#9064ENA nucleic acid pharmaceuticals capable of modifying splicing of mRNA precursors
#9065ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#9066Multiple exon skipping compositions for DMD
#9067Multiple exon skipping compositions for DMD
#9068Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#9069Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#9070Bispecific Antisense Oligonucleotides that Inhibit IGFBP-2 and IGFBP-5 and Methods of Using Same
#9071Diagnostic and treatment for chronic and acute phase myeloid leukemia
#9072METHODS AND COMPOSITIONS FOR MANAGING VASCULAR CONDITIONS
#9073Compositions and methods for modulation of SMN2 splicing in a subject
#9074TOX INHIBITION FOR THE TREATMENT OF CANCER
#9075Cancer treatment
#9076ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS
#9077Notch inhibition in the prevention of vein graft failure
#9078Nanoparticles stabilized with nitrophenylboronic acid compositions
#9079Micro-RNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions
#9080Compositions and Methods for Inhibiting Expression of Eg5 and VEGF Genes
#9081Method and compositions for the genetic control of insect pests in cotton plants by chitin synthase gene silencing
#9082Promoter variants for expressing genes in a fungal cell
#9083Selective antisense compounds and uses thereof
#9084Modified oligonucleotides for telomerase inhibition
#9085Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
#9086Multiple exon skipping compositions for DMD
#9087Multiple exon skipping compositions for DMD
#9088Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#9089Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#9090Modulation of apolipoprotein C-III (ApoCIII) expression in lipoprotein lipase deficient (LPLD) populations
#9091Segmented micro RNA mimetics
#9092CCCTC-Binding Factor (CTCF) RNA Interactome
#9093Oligonucleotide
#9094RNA Modification to Engineer Cas9 Activity
#9095RNA Modification to Engineer Cas9 Activity
#9096Treatment of metastatic tumors
#9097Composition for gene delivery comprising chitosan and liquid crystal formation material
#9098CELL LINES FOR VIRUS PRODUCTION AND METHODS OF USE
#9099STABLE TRANSFORMATION OF A POPULATION AND A METHOD OF BIOCONTAINMENT USING HAPLOINSUFFICIENCY AND UNDERDOMINANCE PRINCIPLES
#9100Treatment of neuropathic pain
#9101Genetic control method and compositions against insect pests in cotton plants by the silencing of genes of the laccase family
#9102COMPOSITIONS AND METHODS OF INHIBITING GENE EXPRESSION IN A LUNG
#9103Diagnosis and treatment of cancers with microrna located in or near cancer-associated chromosomal features
#9104Compositions and methods for treating pancreatic cancer
#9105TREATMENT OF INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1 (IFRD1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IFRD1
#9106OLIGONUCLEOTIDES COMPRISING ALTERNATING SEGMENTS AND USES THEREOF
#9107LNA OLIGONUCLEOTIDE CARBOHYDRATE CONJUGATES
#9108Methods to screen compounds for regulating USF1 activity and methods and compounds to treat cardiometabolic and lipid pathologies
#9109ShRNA molecules and methods of use thereof
#9110Intranuclear protein transduction through a nucleoside salvage pathway
#9111Positively charged polysaccharides for RNA transfection
#9112Suppression of malignant mesothelioma by overexpression or stimulation of endothelial protein C receptors (EPCR)
#9113TREATMENT OF DISORDERS WITH ALTERED VASCULAR BARRIER FUNCTION
#9114PLATELETS TRANSFECTED BY EXOGENOUS GENETIC MATERIAL AND PLATELET MICROPARTICLES OBTAINED BY SAID TRANSFECTED PLATELETS, METHOD FOR THE PREPARATION AND USES THEREOF
#9115Low molecular weight cyclic amine containing cationic lipids for oligonucleotide delivery
#9116Inhibitors of miRNAs 221 and 222 for anti-tumor activity in multiple myeloma
#9117METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#9118Methods for treating eye disorders
#9119Methods and compositions for targeting immunoglobulins
#9120EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
#9121Compositions and methods for inhibiting gene expression of alpha-1 AntiTrypsin
#9122Rotationally sequestered translators
#9123Antisense antibacterial compounds and methods
#9124Method of producing dicer
#9125T cell balance gene expression, compositions of matters and methods of use thereof
#9126INHIBITION OF THE COMPLEMENT SYSTEM
#9127METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING DISEASES
#9128Cancer antigen EEF2
#9129Lipids, lipid complexes and use thereof
#9130Technology for the Preparation of Microparticles
#9131Methods, models, systems, and apparatus for identifying target sequences for Cas enzymes or CRISPR-Cas systems for target sequences and conveying results thereof
#9132Diagnosing IDH1 related subgroups and treatment of cancer
#9133MiRNA targets
#9134Fertility gene and use thereof
#9135Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#9136Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-beta
#9137COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING
#9138Methods of inhibiting proliferation of estrogen-independent cancer cells
#9139Nucleic acids encoding peptides for treating wounds, anti-angiogenic compounds and uses thereof
#9140Plants as functional microRNA and/or functional siRNA carriers, preparation methods and uses thereof
#9141METHOD OF TREATING DELAYED HEALING OF A WOUND ASSOCIATED WITH DIABETES
#9142COMPOSITION COMPRISING AN ENCAPSULATED ANTAGOMIR
#9143Methods and compositions involving miRNA and miRNA inhibitor molecules
#9144Method for diagnosis, prognosis and determination of treatment for cutaneous T-cell lymphoma
#9145METHODS FOR CONTROLLING STEM CELL DIFFERENTIATION
#9146Vectors and methods for genetic immunization
#9147RNAi-related inhibition of TNF-alpha signaling pathway for treatment of ocular angiogenesis
#9148METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#9149Compositions and methods to promote bone formation
#9150Methods and compositions involving miRNA and miRNA inhibitor molecules
#9151Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
#9152Compounds and methods for modulating gene expression
#9153Methods of trans-differentiating a terminally differentiated target cell to a neuron
#9154INTRACELLULAR DELIVERY SYSTEM AND METHODS
#9155Cationic lipid
#9156Genetic Markers Associated with Degenerative Disc Disease and Uses Thereof
#9157Polypeptides Having Cellulolytic Enhancing Activity And Polynucleotides Encoding Same
#9158Methods and compositions to modulate RNA processing
#9159Oligonucleotide compositions and methods of making the same
#9160Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
#9161Splice modulating oligonucleotides that inhibit cancer
#9162Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
#9163Methods and compositions for the production of siRNAs
#9164Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#9165Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#9166Methods and compositions for modulating apolipoprotein (a) expression
#9167Biological control of coleopteran pests
#9168ICAM-1 antisense for the treatment of inflammation and pain in a rectal stump
#9169METHODS TO TREAT ALZHEIMER'S DISEASE USING APOE INHIBITORS
#9170METHODS FOR TREATING INFLAMMATION
#9171Inhibition of choroidal neovascularization
#9172Biomarkers and treatments for heart failure
#9173Analysis of nucleic acids associated with single cells using nucleic acid barcodes
#9174Plant in which expression of a clathrin and/or coatomer subunit is suppressed or inhibited, a method for increasing the production of plant biomass and a method for producing a plant
#9175Methods of treating ischemia-reperfusion injury with siRNAs
#9176Gene Silencing by Single-Stranded Polynucleotides
#9177MiRNA modulators of thermogenesis
#9178GENE SILENCING
#9179SELECTIVE REDUCTION OF ALLELIC VARIANTS
#9180LONG NON-CODING RNA USED FOR ANTICANCER THERAPY
#9181RNA INTERFERENCE TO ACTIVATE STEM CELLS
#9182IDENTIFICATION AND USE OF NEW TUMOR-PROMOTING GENE IN HEMATOLOGICAL MALIGNANCIES
#9183SATB1: A DETERMINANT OF MORPHOGENESIS AND TUMOR METASTATIS
#9184Molecular signatures of ovarian cancer
#9185Compositions and methods for diagnosis, prognosis and treatment of hematological malignancies
#9186Nucleic acid molecules that confer resistance to coleopteran pests
#9187SEC23 NUCLEIC ACID MOLECULES THAT CONFER RESISTANCE TO COLEOPTERAN AND HEMIPTERAN PESTS
#9188Modified oligonucleotides for telomerase inhibition
#9189Modified oligonucleotides for telomerase inhibition
#9190Oligomeric compounds and compositions for the use in modulation of micrornas
#9191Formulations for treating amyloidosis
#9192INDUCTION OF EXON SKIPPING IN EUKARYOTIC CELLS
#9193Post-synthetic orthogonal amidation plus metal catalyzed azide-alkyne cycloaddition click chemistry on siRNA
#9194Compositions and methods for functional nucleic acid delivery
#9195Methods and compositions of improved modified siRNA
#9196Treatment of B-cell lymphoma with microRNA
#9197SNPs OF APOLIPOPROTEIN B AND MODULATION OF THEIR EXPRESSION
#9198COMPOUNDS AND METHODS FOR IMPROVED CELLULAR UPTAKE OF ANTISENSE COMPOUNDS
#9199Cancer treatment and immune system regulation through FAT10 pathway inhibition
#9200Production of therapeutic proteins in genetically modified mammalian cells
#9201Manipulation of hairy and enhancer of split 3 (Hes3) and its regulators/mediators as an anti-cancer strategy
#9202Identification of an inhibitor of iRhom1 or an inhibitor of iRhom2
#9203Mantle phenotype detection in palm
#9204Transferrin/transferrin receptor-mediated siRNA delivery
#9205NICKED OR GAPPED NUCLEIC ACID MOLECULES AND USES THEREOF
#9206Antisense oligonucleotides that target a cryptic splice site in Ush1c as a therapeutic for usher syndrome
#9207Methods of inhibiting cancer stem cells with HMGA1 inhibitors
#9208Methods of delivering multiple targeting oligonucleotides to a cell using cleavable linkers
#9209Multimeric oligonucleotides compounds having cleavable linkers
#9210METHODS OF DELIVERING MULTIPLE TARGETING OLIGONUCLEOTIDES TO A CELL USING NON-NUCLEOTIDE BASED CLEAVABLE LINKERS
#9211Multimeric oligonucleotide compounds having non-nucleotide based cleavable linkers
#9212Compositions and methods for silencing apolipoprotein C-III expression
#9213Methods and compositions for the specific inhibition of CKAP5 by double-stranded RNA
#9214Deep intronic target for splicing correction on spinal muscular atrophy gene
#9215Signal activatable constructs and related components compositions methods and systems
#9216COMPOUNDS AND METHODS FOR IMPROVING CELLULAR UPTAKE OF OLIGOMERIC COMPOUNDS
#9217DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#9218Identification of novel genes coding for small temporal RNAs
#9219Method for inhibiting calcification of a macrophage-derived matrix vesicle
#9220GENETIC DEVICE FOR THE CONTROLLED DESTRUCTION OF DNA
#9221Compositions and methods for selective delivery of oligonucleotide molecules to cell types
#9222Production of stable non-polyadenylated RNAs
#9223Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation
#9224Disulfide masked prodrug compositions and methods
#9225Compositions and methods for polynucleotide transfection
#9226Amphipathic peptide
#9227Composition and method for treating a hematological malignancy
#9228Treatment-induced damage to the tumor micro-environment promotes cancer therapy resistance through extracellular proteins
#9229ACTIVITY-DEPENDENT GENE PAIRS AS THERAPEUTIC TARGETS AND METHODS AND DEVICES TO IDENTIFY THE SAME
#9230RNAI-mediated inhibition of frizzled related protein-1 for treatment of glaucoma
#9231UNA OLIGOMERS HAVING REDUCED OFF-TARGET EFFECTS IN GENE SILENCING
#9232Transthyretin allele selective UNA oligomers for gene silencing
#9233ANOIKIS RESISTANT PLACENTAL STEM CELLS AND USES THEREOF
#9234RNA interference agent, method for producing same, and use therefor
#9235Compositions and their uses directed to huntingtin
#9236DNA ASSIMILATION
#9237Reprogramming of human whartons jelly cells to produce hair cells
#9238Compositions and methods for the display of proteins on the surface of bacteria and their derived vesicles and uses thereof
#9239miRNAs as novel therapeutic adjuvants and biomarkers for the prognosis and treatment of drug resistant breast cancers
#9240Treatment of human cytomegalovirus by modulating Wnt
#9241Nanoliposomal c-MYC-siRNA inhibits in vivo tumor growth of cisplatin-resistant ovarian cancer
#9242COMPOSITIONS AND METHODS TO CONTROL INSECT PESTS
#9243Genetic alterations on chromosomes 21Q, 6Q and 15Q and methods of use thereof for the diagnosis and treatment of type 1 diabetes
#9244Competitive modulation of microRNAs
#9245Transgenic plants with modified sugar content and methods of generating same
#9246Construction of pool of interfering nucleic acids covering entire RNA target sequence and related compositions
#9247Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
#9248METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#9249Methods for treatment of alport syndrome
#9250In vivo gene silencing by chemically modified and stable siRNA
#9251CIRCULAR RNA FOR INHIBITION OF MICRORNA
#9252Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor
#9253EMBEDDED CHIMERIC PEPTIDE NUCLEIC ACIDS AND USES THEREOF
#9254MICROMIRs
#9255METHODS FOR ENGINEERING NON-NEURONAL CELLS INTO NEURONS AND USING NEWLY ENGINEERED NEURONS TO TREAT NEURODEGENERATIVE DISEASES
#9256Compositions and methods for inhibiting hypdxia induced damage
#9257SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
#9258Multimeric oligonucleotides compounds
#9259In vitro production of DNA minicircles comprising less than 250 base pairs
#9260Compositions and methods for inhibiting viral entry
#9261MODULATION OF RENIN-ANGIOTENSIN SYSTEM (RAS) RELATED DISEASES BY ANGIOTENSINOGEN
#9262Methods for treating renal disease
#9263Animal models of neurological disorders
#9264Treatment of angiogenesis disorders
#9265Extraction, preparation, and application of plant micro-ribonucleic acid
#9266RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
#9267MODULATION OF CD40 EXPRESSION
#9268Diagnosis and treatment of endometriosis
#9269ANTI APOB ANTISENSE CONJUGATE COMPOUNDS
#9270METHODS AND COMPOSITIONS TO PRODUCE ss-RNAi ACTIVITY WITH ENHANCED POTENCY
#9271RNA TARGETED TO BETA CATENIN
#9272Antisense compounds targeting genes associated with fibronectin
#9273Organic compositions to treat beta-catenin-related diseases
#9274Exosome transfer of nucleic acids to cells
#9275Short interference RNA gene delivery system for systemic circulation
#9276ARTIFICIAL DNA SEQUENCE WITH OPTIMIZED LEADER FUNCTION IN 5' (5'-UTR) FOR THE IMPROVED EXPRESSION OF HETEROLOGOUS PROTEINS IN PLANTS
#9277Reducing levels of nicotinic alkaloids in plants
#9278Treatment of Sirtuin (SIRT) related diseases by inhibition of natural antisense transcript to a Sirtuin (SIRT)
#9279Methods and compositions for use in treatment of FOXP2-related cancers
#9280Organic compositions to treat HSF1-related diseases
#9281METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#9282METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#9283miRNA169 compositions and methods for the regulation of carbohydrate metabolism and flowering in plants
#9284Therapeutics with conformationally restricted monomers
#9285Oligonucleotide complex compositions and methods of use as gene alteration tools
#9286Poly(vinyl ester) polymers for in vivo nucleic acid delivery
#9287Polymeric nanoparticles
#9288MiRNAs as novel therapeutic targets and diagnostic biomarkers for parkinsons disease
#9289Method for establishing modified host cell
#9290RIG-I ligands and methods for producing them
#9291Delivery of dsRNA to arthropods
#9292METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#9293Oligonucleotide conjugates
#9294ANTISENSE COMPOUNDS AND USES THEREOF
#9295Inhibiting migration of cancer cells
#9296COMPOSITIONS AND METHODS FOR ENHANCING CANCER IMMUNOTHERAPY
#9297SELECTIVE ANTISENSE COMPOUNDS AND USES THEREOF
#9298COMPOSITIONS AND METHODS FOR MODULATING POLYPEPTIDE LOCALIZATION IN PLANTS
#9299POLYMER CONJUGATES FOR DELIVERY OF BIOLOGICALLY ACTIVE AGENTS
#9300Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome